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https://www.readbyqxmd.com/read/28214215/immunoexpression-of-gadd45%C3%AE-in-the-myocardium-of-newborns-experiencing-perinatal-hypoxia
#1
Mona Adalgisa Simões, Francisco Cesar Pabis, Ana Karyn Ehrenfried de Freitas, Marina Luise Viola de Azevedo, Daiane Cristine Martins Ronchi, Lucia de Noronha
AIM: Among the several organs affected by perinatal hypoxia, the heart plays a central role, with cell death caused mainly by apoptosis. One of the biomarkers most often linked to hypoxia-derived apoptosis of cardiomyocytes in animals is Gadd45β. From the published literature, Gadd45β is proposed as a biomarker of hypoxia-induced lesion in cardiomyocytes, both in vitro, as well as in animal models. Our study suggests that this protein can be used as an early biomarker of cell damage in neonate's cardiomyocytes (humans specimens), a process that can ultimately lead to apoptosis...
January 31, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28211647/clinical-characteristics-predicting-abnormal-brain-magnetic-resonance-image-findings-in-hypoxic-ischemic-encephalopathy-infants
#2
Sook K Yum, Cheong-Jun Moon, Young-Ah Youn, In K Sung
BACKGROUND: The aim of this study was to elucidate the specific clinical characteristics associated with abnormal brain magnetic resonance image(MRI) findings in hypoxic ischemic encephalopathy(HIE) infants in order to discern how to predict poorer outcomes more accurately. METHODS: A retrospective data analysis of HIE infants admitted to the neonatal intensive care unit of a tertiary hospital was performed. Baseline perinatal information and physical and neurological findings were compared in HIE infants according to the presence of abnormal brain MRI findings...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28210092/first-successful-perinatal-management-of-pregnancy-after-abo-incompatible-liver-transplantation
#3
Hisanobu Higashi, Hideaki Obara, Kei Miyakoshi, Masahiro Shinoda, Minoru Kitago, Naoki Shimojima, Yuta Abe, Taizo Hibi, Hiroshi Yagi, Kentaro Matsubara, Yohei Yamada, Osamu Itano, Ken Hoshino, Tatsuo Kuroda, Yuko Kitagawa
Many papers have reported on pregnancy and delivery after liver transplantation, but there have been no reports on pregnancy after ABO-incompatible liver transplantation. This paper reports the first successful pregnancy and delivery of a newborn after ABO-incompatible liver transplantation for fulminant hepatic failure. The patient was a 39-year-old female. She had an ABO-incompatible liver transplantation, donated from her husband, due to subacute fulminant hepatitis of unknown etiology. She was taking tacrolimus, methylprednisolone, and mizoribine orally for the maintenance of immunosuppression at the time of discharge...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28210010/evaluation-and-treatment-of-anemia-in-premature-infants
#4
Edo Hasanbegovic, Nermana Cengic, Snijezana Hasanbegovic, Jasmina Heljic, Ismail Lutolli, Edin Begic
INTRODUCTION: Anemia in preterm infants is the pathophysiological process with greater and more rapid decline in hemoglobin compared to the physiological anemia in infants. There is a need for transfusions and administration of human recombinant erythropoietin. AIM: To determine the frequency of anemia in premature infants at the Pediatric Clinic, University Clinical Center Sarajevo, as well as parameter values in the blood count of premature infants and to explore a relationship between blood transfusions with the advent of intraventricular hemorrhage (determine treatment outcome in preterm infants)...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28209547/pregnancy-after-urinary-diversion-at-young-ages-risks-and-outcome
#5
N Huck, S Schweizerhof, P Honeck, A Neisius, J Thüroff, R Stein
OBJECTIVE: To assess the urological and obstetric outcomes during and after pregnancy following urinary diversion (UD) performed during childhood or adolescence. PATIENTS AND METHODS: From our urinary diversion database, we identified 25 females who became pregnant between 1981 and 2013. Reasons for urinary diversion were neurogenic bladder, exstrophy, trauma, sinus urogenitalis and interstitial cystitis. 17 had continent cutaneous diversion, 4 continent anal diversion and 4 colonic conduit...
February 13, 2017: Urology
https://www.readbyqxmd.com/read/28208945/perinatal-outcome-of-second-twin-with-respect-to-mode-of-delivery-an-observational-study
#6
Rujul Rashmin Jhaveri, Trupti K Nadkarni
INTRODUCTION: With the advent of assisted reproductive techniques, multi-fetal pregnancies are on the rise. While caesarean section is the defined mode of delivery for triplets and higher order pregnancies, the picture for twin delivery is not so clear. While a trial for vaginal delivery is attempted, the second twin is considered vulnerable to complications. Whether this translates into worsened perinatal outcomes is not well defined. AIM: To study the perinatal outcome and to identify the various factors influencing the perinatal outcome of second twin with respect to mode of delivery...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208944/the-effect-of-fetal-gender-on-the-delivery-outcome-in-primigravidae-women-with-induced-labours-for-all-indications
#7
Angeliki Antonakou, Dimitrios Papoutsis
INTRODUCTION: There is increasing evidence of a gender-related phenomenon where the presence of a male fetus may have an adverse effect on the outcome of pregnancy. AIM: The aim of this study was to investigate the effect of fetal gender on the delivery outcome in primigravidae women with induced labours. MATERIALS AND METHODS: This was an observational cohort study of primigravidae women who had Induction Of Labour (IOL) for all indications during a two-year period...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28204882/comparison-between-vaginal-and-sublingual-misoprostol-50%C3%A2-%C3%A2%C2%B5g-for-cervical-ripening-prior-to-induction-of-labor-randomized-clinical-trial
#8
Andrés Conde, Sebastián Ben, Josefina Tarigo, Santiago Artucio, Virginia Varela, Pamela Grimaldi, Claudio Sosa, Justo Alonso
OBJECTIVE: To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the Bishop score after 6 h of administration. METHODS: Randomized clinical trial which includes pregnant women in gestational ages from 32/0 to 41/6, with indication of induction of labor with misoprostol. Bishop score was assessed at the time of induction and 6 h after administration of 50 µg misoprostol. Analysis was made over difference in mean Bishop score of 2 points, using a standard deviation of 2, with 90% power, reaching a 95% confidence interval...
February 16, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28203330/risk-factors-for-health-care-associated-bloodstream-infections-in-a-neonatal-intensive-care-unit
#9
Sabahattin Ertugrul, Fesih Aktar, Ilyas Yolbas, Ahmet Yilmaz, Bilal Elbey, Ahmet Yildirim, Kamil Yilmaz, Recep Tekin
BACKGROUND: Healthcare-associated bloodstream infections (HCA-BSI) are a major cause of morbidity and mortality in neonatal intensive care units (NICUs). OBJECTIVES: We aimed to determine the causative organisms and risk factors of HCA-BSIs in NICUs. METHODS: This study was performed between January 2011 and December 2014 in the neonatal intensive care unit of Dicle university, Turkey. The study consisted of 126 patients (infected group) with positive blood culture and 126 randomly selected patients (uninfected control group) with negative blood culture after four days of hospitalization...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28191626/intermittent-auscultation-ia-of-fetal-heart-rate-in-labour-for-fetal-well-being
#10
REVIEW
Ruth Martis, Ova Emilia, Detty S Nurdiati, Julie Brown
BACKGROUND: The goal of fetal monitoring in labour is the early detection of a hypoxic baby. There are a variety of tools and methods available for intermittent auscultation (IA) of the fetal heart rate (FHR). Low- and middle-income countries usually have only access to a Pinard/Laënnec or the use of a hand-held Doppler device. Currently, there is no robust evidence to guide clinical practice on the most effective IA tool to use, timing intervals and length of listening to the fetal heart for women during established labour...
February 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28186614/decline-in-stillbirths-and-perinatal-mortality-after-implementation-of-a-more-aggressive-induction-policy-in-post-date-pregnancies-a-nationwide-register-study
#11
Anne R Zizzo, Ida Kirkegaard, Anja Pinborg, Niels Ulbjerg
INTRODUCTION: In 2011 the Danish national guidelines were changed towards a more aggressive induction and fetal surveillance policy from 1) induction of labor at gestational age (GA) of 42(+0) weeks and 2) no fetal surveillance after 40(+0) to 1) induction of labor between 41(+2) -41(+6) , 2) earlier induction at 41(+0) weeks in case of maternal age > 40 years or body mass index (BMI) > 35 kg/m(2) and 3) fetal surveillance at GA 41(+0) . MATERIAL AND METHODS: This national cohort study included all pregnancies that reached 41(+0) weeks of gestation from 2008 to 2014 (N=102 167)...
February 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28183504/a-6-month-old-infant-with-different-capnography-values-in-polysomnography
#12
Lourdes M DelRosso, Pacifico Palacay, Ngoc P Ly
A 6-month-old infant with a past medical history of hypoxic ischemic encephalopathy was referred for evaluation of snoring. She was born at 41 weeks' gestational age to a 25-year-old gravida 1, para 1 mother via vacuum-assisted delivery due to cardiac decelerations. The infant's Apgar scores were 1, 4, and 6 with nuchal cord and meconium at delivery. She was started on positive-pressure ventilation but eventually required intubation at approximately 40 minutes of life. Brain MRI showed abnormal areas of restricted diffusion, involving the corpus callosum, bilateral posterior limb of the internal capsules, and possible scattered areas of frontal and occipital lobe cortices...
February 2017: Chest
https://www.readbyqxmd.com/read/28181995/is-the-bishop-score-significant-in-predicting-the-success-of-labor-induction-in-multiparous-women
#13
D Navve, N Orenstein, R Ribak, Y Daykan, G Shechter-Maor, T Biron-Shental
OBJECTIVE: To determine whether the Bishop-score upon admission effects mode of delivery, maternal or neonatal outcomes of labor induction in multiparous women. STUDY DESIGN: A retrospective study including 600 multiparous women with a singleton pregnancy, 34 gestational weeks and above who underwent labor induction for maternal, fetal or combined indications. Induction was performed with one of three methods- oxytocin, a slow release vaginal prostaglandin E2 insert (10 mg dinoprostone) or a transcervical double balloon catheter...
February 9, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28180016/effect-of-saffron-fan-hong-hua-on-the-readiness-of-the-uterine-cervix-in-term-pregnancy-a-placebo-controlled-randomized-trial
#14
Roghaieh Sadi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand, Yousef Javadzadeh, Afkham Ahmadi-Bonabi
BACKGROUND: Readiness of the cervix is required for successful induction of labor, and there are a number of ways in which this can be achieved. OBJECTIVES: The aim of the present study was to assess whether taking saffron orally could have an effect on the cervical readiness (primary outcome) and some delivery and neonatal outcomes (secondary outcomes) in women in the stage of term pregnancy. PATIENTS AND METHODS: In this double-blind trial, 50 women with a gestational age of 39 to 41 weeks, no indication of cesarean section, a Bishop's score of less than 4, who had plan to have vaginal delivery at Shohada hospital of Bonab, Iran were randomized into two groups receiving three 250mg saffron or placebo pills in 24 hours...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28178064/association-between-senior-obstetrician-supervision-of-resident-deliveries-and-mode-of-delivery
#15
Jonah Bardos, Holly Loudon, Patricia Rekawek, Frederick Friedman, Michael Brodman, Nathan S Fox
OBJECTIVE: In December 2012, the Mount Sinai Hospital implemented a program to have senior obstetricians (more than 20 years of experience) supervise residents on labor and delivery during the daytime. The objective of this study was to estimate the association of resident supervision by senior obstetricians with mode of delivery. METHODS: This was a retrospective cohort study of all resident deliveries at Mount Sinai from July 2011 to June 2015. We included all patients with live, term, singleton, vertex fetuses...
February 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28176333/selective-versus-routine-use-of-episiotomy-for-vaginal-birth
#16
REVIEW
Hong Jiang, Xu Qian, Guillermo Carroli, Paul Garner
BACKGROUND: Some clinicians believe that routine episiotomy, a surgical cut of the vagina and perineum, will prevent serious tears during childbirth. On the other hand, an episiotomy guarantees perineal trauma and sutures. OBJECTIVES: To assess the effects on mother and baby of a policy of selective episiotomy ('only if needed') compared with a policy of routine episiotomy ('part of routine management') for vaginal births. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register (14 September 2016) and reference lists of retrieved studies...
February 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28165570/effect-of-serum-high-molecular-weight-adiponectin-level-on-the-occurrence-of-eclampsia-during-subsequent-pregnancy-in-patients-with-primary-pregnancy-induced-hypertension
#17
Y Zhou, Z-H Chen, X-L Zhao, Y-H Qiao, R-X Guo
OBJECTIVE: To analyze the effect of serum levels of high molecular weight adiponectin (HMWA) on the occurrence of eclampsia during subsequent pregnancy in patients with primary pregnancy-induced hypertension (PIH). PATIENTS AND METHODS: Thirty patients with primary PIH (observation group) and sixty patients without primary PIH (control group) were consecutively selected. ELISA was used to measure the serum levels of HMWA. The differences in the occurrence of eclampsia during subsequent pregnancy between the two groups were compared...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28165176/cardiotocographic-parameters-in-small-for-gestational-age-fetuses-how-do-they-vary-from-normal-at-different-gestational-ages-a-study-of-11687-fetuses-from-25-to-40-weeks-of-pregnancy
#18
Célia Amorim-Costa, Diogo Ayres de Campos, João Bernardes
AIM: The aim of this study was to assess how cardiotocographic (CTG) parameters differ between small-for-gestational-age (SGA) and normal fetuses at different gestational ages. METHODS: This was a retrospective cross-sectional study using the first antepartum tracing of singleton pregnancies with no malformations. Fetuses with birthweight ≥10th percentile for gestational age and other normal pregnancy outcome criteria (term birth, normal umbilical artery pH and Apgar scores, no intensive care unit admission) were compared with fetuses with birthweight <10th and <3rd percentiles for gestational age (SGA < p10 and SGA < p3, a subgroup of the latter)...
February 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28164607/serum-levels-of-cardiac-troponin-i-in-asphyxiated-neonates-predict-mortality
#19
Wen-Jie Zhou, Fan Yu, Jing Shi, Hui Yang, Sheng-Jie Zou, Yong-Mei Jiang
BACKGROUND: Cardiac troponin I (cTnI) is a well-established marker for detecting myocardial ischemic damage in neonates with hypoxic-ischemic encephalopathy. However, the predictive value of cTnI in assessing mortality in neonatal asphyxia remains obscure. This retrospective study aims to analyze the relationship between cTnI levels in blood serum with gestational age, birth weight, gender, delivery type, electrocardiography, echocardiography, Apgar scores, length of hospital stay, and mortality in asphyxiated neonates...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164585/role-of-serum-level-of-neurometals-copper-zinc-and-magnesium-in-neonates-with-hypoxic-ischemic-encephalopathy
#20
Mostafa A El Foley, Hanan M Kamel, Samir M Mounir, Samuel N Habeb
BACKGROUND: Perinatal HIE is associated with high morbidity and mortality rates worldwide, despite the improvements in perinatal care. The aim of this study was to evaluate the role Cu, Zn, and Mg+2 neurometals in the development of neonatal hypoxic ischemic encephalopathy. METHODS: This study included two groups: group 1 (study group): Thirty full term, and diagnosed as having hypoxic ischemic encephalopathy. Group 2 (control group): Thirty full term healthy neonates...
September 1, 2016: Clinical Laboratory
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