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https://www.readbyqxmd.com/read/27859354/public-challenge-and-endorsement-of-sex-category-ambiguity-in-online-debate-the-sooner-people-stop-thinking-that-gender-is-a-matter-of-choice-the-better
#1
Helen Sweeting, Matthew William Maycock, Laura Walker, Kate Hunt
Despite academic feminist debate over several decades, the binary nature of sex as a (perhaps the) primary social classification is often taken for granted, as is the assumption that individuals can be unproblematically assigned a biological sex at birth. This article presents analysis of online debate on the BBC news website in November 2013, comprising 864 readers' responses to an article entitled 'Germany allows 'indeterminate' gender at birth'. It explores how discourse reflecting Western essentialist beliefs about people having one sex or 'the other' is maintained in debates conducted in this online public space...
November 16, 2016: Sociology of Health & Illness
https://www.readbyqxmd.com/read/27856399/enhanced-laws-textures-a-potential-mri-surrogate-marker-of-hepatic-fibrosis-in-a-murine-model
#2
Baojun Li, Hernan Jara, Heishun Yu, Michael O'Brien, Jorge Soto, Stephan W Anderson
PURPOSE: To compare enhanced Laws textures derived from parametric proton density (PD) maps to other MRI surrogate markers (T2, PD, apparent diffusion coefficient (ADC)) in assessing degrees of liver fibrosis in an ex vivo murine model of hepatic fibrosis imaged using 11.7T MRI. METHODS: This animal study was IACUC approved. Fourteen male, C57BL/6 mice were divided into control and experimental groups. The latter were fed a 3,5-dicarbethoxy-1,4-dihydrocollidine (DDC) supplemented diet to induce hepatic fibrosis...
November 14, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27854052/laws-of-organization-and-chemical-analysis-blainville-and-m%C3%A3-ller
#3
François Duchesneau
When "general physiology" emerged as a basic field of research within biology in the early nineteenth century, Henri Ducrotay de Blainville (1777-1850) on the one hand and Johannes Peter Müller (1801-1858) on the other appealed to chemical analysis to account for the properties and operations of organisms that were observed to differ from what was found in inorganic compounds. Their aim was to establish laws of vital organization that would be based on organic chemical processes, but would also be of use to explain morphological and functional differences among life forms...
December 2016: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/27837058/action-plan-for-improving-enforcement-of-animal-welfare-law-in-northern-ireland
#4
(no author information available yet)
No abstract text is available yet for this article.
November 12, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27822501/inhibition-of-ikk%C3%AE-reduces-ethanol-consumption-in-c57bl-6j-mice
#5
Jay M Truitt, Yuri A Blednov, Jillian M Benavidez, Mendy Black, Olga Ponomareva, Jade Law, Morgan Merriman, Sami Horani, Kelly Jameson, Amy W Lasek, R Adron Harris, R Dayne Mayfield
Proinflammatory pathways in neuronal and non-neuronal cells are implicated in the acute and chronic effects of alcohol exposure in animal models and humans. The nuclear factor-κB (NF-κB) family of DNA transcription factors plays important roles in inflammatory diseases. The kinase IKKβ mediates the phosphorylation and subsequent proteasomal degradation of cytosolic protein inhibitors of NF-κB, leading to activation of NF-κB. The role of IKKβ as a potential regulator of excessive alcohol drinking had not previously been investigated...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27805823/it-takes-a-village-stakeholder-participation-is-essential-to-transforming-science
#6
REVIEW
Kristie Sullivan
Efforts toward replacing the use of animals in toxicology testing have begun to make significant headway in the last several years, due to co-operative and pragmatic efforts on the part of many stakeholders, and the public pressure that non-governmental advocacy organisations represent. Science-focused advocacy organisations have a unique role to play in these efforts, as they often have flexibility to adapt quickly to keep a project going and forge connections among different kinds of stakeholders to help encourage buy-in...
October 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/27795422/native-folding-of-a-recombinant-gpe1-gpe2-heterodimer-vaccine-antigen-from-a-precursor-protein-fused-with-fc-igg
#7
Michael Logan, John Law, Jason Alexander Ji-Xhin Wong, Darren Hockman, Amir Landi, Chao Chen, Kevin Crawford, Juthika Kundu, Lesley Baldwin, Janelle Johnson, Anita Dahiya, Gerald LaChance, Joseph Marcotrigiano, Mansun Law, Steven Foung, Lorne Tyrrell, Michael Houghton
: A recombinant HCV-1 (1a) gpE1/gpE2 (E1E2) vaccine candidate was previously shown by our group to protect chimpanzees and generate broad cross-neutralizing antibodies in animals and humans. In addition, recent independent studies have highlighted the importance of conserved neutralizing epitopes in HCV vaccine development that map to antigenic clusters in E2 or the E1E2 heterodimer. E1E2 can be purified using Galanthis nivalis lectin agarose (GNA), but this technique is suboptimal for global production...
October 19, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27779423/changing-attitudes-and-animal-welfare-in-small-island-developing-states-dogs-on-new-providence-the-bahamas
#8
William J Fielding
This article compares results from a study in 2014 with a similar study from 1998 (Fielding, 1999 ) to examine changes in the care of dogs in New Providence, The Bahamas. The results from a survey of 379 residents indicated a general lack of improvement in matters associated with the care of dogs during the past 16 years. For example, in 1998, it was estimated that 35% of caregivers had at least 1 dog sterilized, and in 2014, the corresponding figure was 37%. In 1998, 14% of households with dogs allowed their dogs to roam compared with 41...
October 25, 2016: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/27767390/exceptionalist-naturalism-human-agency-and-the-causal-order
#9
John Turri
This paper addresses a fundamental question in folk metaphysics: how do we ordinarily view human agency? According to the transcendence account, we view human agency as standing outside of the causal order and imbued with exceptional powers. According to a naturalistic account, we view human agency as subject to the same physical laws as other objects and completely open to scientific investigation. According to exceptionalist naturalism, the truth lies somewhere in between: we view human agency as fitting broadly within the causal order while still being exceptional in important respects...
October 21, 2016: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/27761352/exclusions-for-resolving-urban-badger-damage-problems-outcomes-and-consequences
#10
Alastair I Ward, Jason K Finney, Sarah E Beatham, Richard J Delahay, Peter A Robertson, David P Cowan
Increasing urbanisation and growth of many wild animal populations can result in a greater frequency of human-wildlife conflicts. However, traditional lethal methods of wildlife control are becoming less favoured than non-lethal approaches, particularly when problems involve charismatic species in urban areas. Eurasian badgers (Meles meles) excavate subterranean burrow systems (setts), which can become large and complex. Larger setts within which breeding takes place and that are in constant use are known as main setts...
2016: PeerJ
https://www.readbyqxmd.com/read/27747208/road-traffic-injury-as-a-major-public-health-issue-in-the-kingdom-of-saudi-arabia-a-review
#11
Erica DeNicola, Omar S Aburizaize, Azhar Siddique, Haider Khwaja, David O Carpenter
Injury was the largest single cause of disability-adjusted life years and death in the Kingdom of Saudi Arabia in 2013. The vast majority of injury-related fatalities are deaths caused by road traffic. Measures to control this serious public health issue, which has significant consequences for both Saudi families and the Saudi economy as a whole, have been underway for years but with little success. Most attempts at intervening revolve around attempts for enforcing stricter traffic laws and by installing automated traffic monitoring systems that will catch law breakers on camera and issue tickets and fines...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27725143/analysis-of-hematopathology-and-alteration-of-jak1-stat3-stat5-signaling-axis-in-experimental-myelodysplastic-syndrome
#12
Suchismita Daw, Ritam Chatterjee, Aditya Law, Sujata Law
Hematological disorders like myelodysplastic syndrome (MDS) may arise due to cumulative dysregulation of various signalling pathways controlling proliferation, differentiation, maturation and apoptosis of bone marrow cells. This devastating bone marrow condition can be due to consequential abnormalities in haematopoiesis as well as its supportive microenvironment. Although mutations related to JAK/STAT pathway are common in myeloproliferative neoplasms, further studies are required to fully explore the myelodysplastic scenario regarding the concerned pathway...
October 8, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27703102/-drug-dependence-and-toxicity-of-law-evading-drugs-their-mechanisms-explored-from-basic-research
#13
Masahiko Funada
The number of law-evading chemical substances that pose serious health risks to humans is increasing worldwide, including Japan and the Western world, and their abuse is becoming a serious social problem. Analysis of the chemical substances in these herbal products revealed the presence of synthetic cannabinoids. This review summarizes the pharmacological actions and dangers of chemical substances contained in law-evading herbal products by focusing on synthetic cannabinoids as a group of chemical substances contained in these products...
October 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27701742/the-new-israeli-feed-safety-law-challenges-in-relation-to-animal-and-public-health
#14
REVIEW
Shimon Barel, Dani Elad, Olga Cuneah, Jakob A Shimshoni
The Israeli feed safety legislation, which came to prominence in the early 1970s, has undergone a major change from simple feed safety and quality regulations to a more holistic concept of control of feed safety and quality throughout the whole feed production chain, from farm to the end user table. In February 2014, a new law was approved by the Israeli parliament, namely the Control of Animal Feed Law, which is expected to enter into effect in 2017. The law is intended to regulate the production and marketing of animal feed, guaranteeing the safety and quality of animal products throughout the production chain...
October 4, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27692181/a-mechanistic-approach-to-the-development-of-gene-therapy-for-chronic-pain
#15
C Kibaly, H H Loh, P-Y Law
Treatment of chronic pain has created a "silent epidemic," a term that describes the serious public health problem of the abuse of opioid painkillers and other prescription drugs. Conventional pharmacotherapy is limited by the loss of effectiveness in the long-term and by potentially lethal side effects. Efforts need to be focused on the development of nonpharmacological approaches. As significant progress is made in the viral vector technology, gene therapy involving recombinant viruses as vehicles may become a viable alternative for treatment of severe pain...
2016: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/27689948/professional-veterinary-programs-perceptions-and-experiences-pertaining-to-emotional-support-animals-and-service-animals-and-recommendations-for-policy-development
#16
Regina Schoenfeld-Tacher, Lori R Kogan
Given the unique nature of programs in professional veterinary medicine (PVM), the increasing numbers of students requesting accommodations for emotional support animals (ESAs) in higher education settings is of growing interest to student affairs and administrative staff in PVM settings. Since the legislation pertaining to this type of support animal differs from the laws governing disability service animals, colleges and universities now need to develop new policies and guidelines. Representatives from a sample of 28 PVM programs completed a survey about the prevalence of student requests for ESAs and service animals...
September 30, 2016: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/27649240/current-hypothesis-for-the-relationship-between-dietary-rice-bran-intake-the-intestinal-microbiota-and-colorectal-cancer-prevention
#17
Winnie K W So, Bernard M H Law, Patrick T W Law, Carmen W H Chan, Sek Ying Chair
Globally, colorectal cancer (CRC) is the third most common form of cancer. The development of effective chemopreventive strategies to reduce CRC incidence is therefore of paramount importance. Over the past decade, research has indicated the potential of rice bran, a byproduct of rice milling, in CRC chemoprevention. This was recently suggested to be partly attributable to modification in the composition of intestinal microbiota when rice bran was ingested. Indeed, previous studies have reported changes in the population size of certain bacterial species, or microbial dysbiosis, in the intestines of CRC patients and animal models...
2016: Nutrients
https://www.readbyqxmd.com/read/27627810/generation-of-an-in%C3%A2-vitro-3d-pdac-stroma-rich-spheroid-model
#18
Matthew J Ware, Vazrik Keshishian, Justin J Law, Jason C Ho, Carlos A Favela, Paul Rees, Billie Smith, Sayeeduddin Mohammad, Rosa F Hwang, Kimal Rajapakshe, Cristian Coarfa, Shixia Huang, Dean P Edwards, Stuart J Corr, Biana Godin, Steven A Curley
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease. Therefore, greater understanding of the stroma development and tumor-stroma interactions is highly required. Pancreatic stellate cells (PSC) are myofibroblast-like cells located in exocrine areas of the pancreas, which as a result of inflammation produced by PDAC migrate and accumulate in the tumor mass, secreting extracellular matrix components and producing the dense PDAC stroma...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27621011/patterns-of-injury-among-motorized-two-wheeler-pillion-riders-in-new-delhi-india
#19
Selma Marie Siddiqui, Sushma Sagar, Mahesh C Misra, Amit Gupta, Marie Crandall, Mamta Swaroop
BACKGROUND: Motorized two-wheelers (MTWs) such as scooters and motorcycles place drivers and passengers at significant risk of injury and death in the event of a road traffic accident. In India, where road traffic is poorly regulated and consists of vehicles ranging from semitrucks to animal carts, the MTW pillion rider (backseat passenger) is particularly vulnerable. Annually, approximately 140,000 Indians are injured or killed in MTW road traffic accidents. In 2011, the city of New Delhi renewed a mandatory helmet use exemption for its 8 million women...
September 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27555220/understanding-the-spatiotemporal-pattern-of-grazing-cattle-movement
#20
Kun Zhao, Raja Jurdak
Understanding the drivers of animal movement is significant for ecology and biology. Yet researchers have so far been unable to fully understand these drivers, largely due to low data resolution. In this study, we analyse a high-frequency movement dataset for a group of grazing cattle and investigate their spatiotemporal patterns using a simple two-state 'stop-and-move' mobility model. We find that the dispersal kernel in the moving state is best described by a mixture exponential distribution, indicating the hierarchical nature of the movement...
2016: Scientific Reports
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