keyword
MENU ▼
Read by QxMD icon Read
search

MiR93

keyword
https://www.readbyqxmd.com/read/27665403/mirna-93-5p-and-other-mirnas-as-predictors-of-coronary-artery-disease-and-stemi
#1
John F O Sullivan, Antoinette Neylon, Catherine McGorrian, Gavin J Blake
BACKGROUND: MicroRNAs (miRNAs), small non-coding RNAs, have been implicated as regulators of all mediators of atherosclerosis, and some reports have suggested increased levels in coronary artery disease (CAD) and acute myocardial infarction (AMI). However, the potential of miRNAs as biomarkers or predictors of disease remains to be established. METHODS: We designed a study comprising 150 patients (50 Control, 50 Stable CAD, and 50 ST Elevation Myocardial Infarction (STEMI)), and measured plasma miRNAs in each...
December 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27342518/-correlation-between-plasma-microrna-expression-and-acute-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplantation
#2
Bin Hu, Wei Fu, Si-Yong Huang, Xiao-Tong Gao, Dan-Hui Li, Xue-Qian Yan, Yang-Ping Zhang, Qiang Liu, Li Liu, Ying-Min Liang
OBJECTIVE: To investigate the microRNA (miRNA) expression in plasma of patients with aGVHD and without aGVHD after allo-hematopoietic stem cell transplantation (allo-HSCT). METHODS: The miRNAs (miR-423, mirR199a-3p, miR93*, miR377) expression levels in peripheral blood plasma of 25 patients before and after allo-HSCT were detected by real-time PCR. RESULTS: miR-423, miR199a-3p and miR-93* in aGVHD group were significantly upregulated (P<0...
June 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/24643999/genetic-association-of-gastric-cancer-with-mirna-clusters-including-the-cancer-related-genes-mir29-mir25-mir93-and-mir106-results-from-the-epic-eurgast-study
#3
MULTICENTER STUDY
Yolanda Espinosa-Parrilla, Xavier Muñoz, Catalina Bonet, Nadia Garcia, Adoración Venceslá, Nikos Yiannakouris, Alessio Naccarati, Sabina Sieri, Salvatore Panico, José M Huerta, Aurelio Barricarte, Virginia Menéndez, Emilio Sánchez-Cantalejo, Miren Dorronsoro, Paul Brennan, Talita Duarte-Salles, H B As Bueno-de-Mesquita, Elisabete Weiderpass, Eiliv Lund, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Antoine Racine, Mattijs E Numans, Rosario Tumino, Federico Canzian, Daniele Campa, Malin Sund, Mattias Johansson, Bodil Ohlsson, Björn Lindkvist, Kim Overvad, Anne Tjønneland, Domenico Palli, Ruth C Travis, Kay-Tee Khaw, Nick Wareham, Heiner Boeing, Gabriella Nesi, Elio Riboli, Carlos A Gonzalez, Núria Sala
MicroRNAs (miRNAs) are post-transcriptional gene regulators involved in a wide range of biological processes including tumorigenesis. Deregulation of miRNA pathways has been associated with cancer but the contribution of their genetic variability to this disorder is poorly known. We analyzed the genetic association of gastric cancer (GC) and its anatomical and histological subtypes, with 133 single-nucleotide polymorphisms (SNPs) tagging 15 isolated miRNAs and 24 miRNA clusters potentially involved in cancer, in 365 GC cases and 1,284 matched controls within the European Prospective Investigation into Cancer and Nutrition cohort...
November 1, 2014: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/24036151/mir106b-and-mir93-prevent-removal-of-bacteria-from-epithelial-cells-by-disrupting-atg16l1-mediated-autophagy
#4
Changming Lu, Jianfeng Chen, Hua-Guo Xu, Xianzheng Zhou, Qiongqiong He, Yu-Lin Li, Guoqing Jiang, Yuxi Shan, Boxin Xue, Rui-Xun Zhao, Yong Wang, Kaitlin D Werle, Rutao Cui, Jiyong Liang, Zhi-Xiang Xu
BACKGROUND & AIMS: Variants in genes that regulate autophagy have been associated with Crohn's disease (CD). Defects in autophagy-mediated removal of pathogenic microbes could contribute to the pathogenesis of CD. We investigated the role of the microRNAs (miRs) MIR106B and MIR93 in induction of autophagy and bacterial clearance in human cell lines and the correlation between MIR106B and autophagy-related gene 16L1 (ATG16L1) expression in tissues from patients with CD. METHODS: We studied the ability of MIR106B and MIR93 to regulate ATG transcripts in human cancer cell lines (HCT116, SW480, HeLa, and U2OS) using luciferase report assays and bioinformatics analyses; MIR106B and MIR93 mimics and antagonists were transfected into cells to modify levels of miRs...
January 2014: Gastroenterology
https://www.readbyqxmd.com/read/23904466/micrornas-new-candidates-for-the-regulation-of-the-human-cumulus-oocyte-complex
#5
S Assou, T Al-edani, D Haouzi, N Philippe, C-H Lecellier, D Piquemal, T Commes, O Aït-Ahmed, H Dechaud, S Hamamah
STUDY QUESTION: What is the expression pattern of microRNAs (miRNAs) in human cumulus-oocyte complexes (COCs)? SUMMARY ANSWER: Several miRNAs are enriched in cumulus cells (CCs) or oocytes, and are predicted to target genes involved in biological functions of the COC. WHAT IS KNOWN ALREADY: The transcriptional profiles of human MII oocytes and the surrounding CCs are known. However, very limited data are available about post-transcriptional regulators, such as miRNAs...
November 2013: Human Reproduction
https://www.readbyqxmd.com/read/23679328/expression-of-mir200a-mir93-metastasis-related-gene-reck-and-mmp2-mmp9-in-human-cervical-carcinoma-relationship-with-prognosis
#6
COMPARATIVE STUDY
Ling Wang, Qiang Wang, He-Lian Li, Li-Ying Han
AIM AND BACKGROUND: Cervical cancer remains the third most common cancer in women globally after breast and colorectal cancer. Well-characterized biomarkers are necessary for early diagnosis and to predict metastatic progression and effective therapy. MiRNAs can regulate gene expression, cell growth, differentiation and apoptosis by targeting mRNAs for translational repression or degradation in tumor cells. The present study was conducted to assess expression of miR93, miR200a, RECK, MMP2, MMP9 in invasive cervical carcinoma, and analyze their clinical significance...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/21538479/microarray-profiling-of-monocytic-differentiation-reveals-mirna-mrna-intrinsic-correlation
#7
Jing Wang, Guangxing Xiang, Keith Mitchelson, Yuxiang Zhou
MiRNAs (microRNAs) are small non-coding RNAs involved in mammalian gene expression of cellular processes including differentiation, apoptosis and cancer development. Both specific miRNAs and mRNAs have been identified during monocytic differentiation, but their interactions have not been fully characterized. Here we report that by genome-wide microarray analysis for U937 monocytic differentiation induced by TPA, a large number of miRNAs and mRNAs were differentially expressed, and by bioinformatics analysis could demonstrate that their functional pathway patterns overlap strongly...
September 2011: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/17613256/hypersusceptibility-to-vesicular-stomatitis-virus-infection-in-dicer1-deficient-mice-is-due-to-impaired-mir24-and-mir93-expression
#8
Motoyuki Otsuka, Qing Jing, Philippe Georgel, Liguo New, Jianming Chen, Johann Mols, Young Jun Kang, Zhengfan Jiang, Xin Du, Ryan Cook, Subash C Das, Asit K Pattnaik, Bruce Beutler, Jiahuai Han
Dicer is essential for plant, Caenorhabditis elegans, and Drosophila antiviral responses because of its role in generating small interfering RNA (siRNA) from viral genomes. We show that because of impaired miRNA production, mice with a variant Dicer1 allele (Dicer1(d/d)) were more susceptible to vesicular stomatitis virus (VSV) infection. We did not detect VSV genome-derived siRNA in wild-type cells or any alteration of interferon-mediated antiviral responses by Dicer1 deficiency. Rather, we found that host miR24 and miR93 could target viral large protein (L protein) and phosphoprotein (P protein) genes, and a lack of miR24 and miR93 was responsible for increased VSV replication in Dicer1(d/d) cells...
July 2007: Immunity
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"