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https://www.readbyqxmd.com/read/29627523/mircorna-3162-3p-is-a-potential-biomarker-to-identify-new-infections-in-hiv-1-infected-patients
#1
Jiegang Huang, Jingzhen Lai, Bingyu Liang, Junjun Jiang, Chuanyi Ning, Yanyan Liao, Ning Zang, Minlian Wang, Fengxiang Qin, Jun Yu, Wudi Wei, Li Ye, Hao Liang
BACKGROUND: Identification of new HIV infections (HIV incidence) is critical for monitoring AIDS epidemic and assessing the effectiveness of intervention measures. However, current methods for distinguishing new infections from newly diagnosed HIV-1 patients are still imperfect. We explored utilizing miRNAs as biomarker to identify HIV new infections. METHODS: According to the HIV-1 status and the estimated duration of infection (EDI), we enrolled participants and divided them into three groups: healthy control, new infection (within 1 year), and old infection (longer than 1 year)...
April 5, 2018: Gene
https://www.readbyqxmd.com/read/29556286/microrna-499a-5p-inhibits-osteosarcoma-cell-proliferation-and-differentiation-by-targeting-protein-phosphatase-1d-through-protein-kinase-b-glycogen-synthase-kinase-3%C3%AE-signaling
#2
Jun Liu, Lei Huang, Pengxiao Su, Tao Song, Wentao Zhang, Jinzhu Fan, Yang Liu
A number of studies have attempted to elucidate the association between mircoRNAs (miRNAs/miRs) and cancer-associated processes. The aim of the present study was to determine how miR-499a-5p intervenes in human osteosarcoma cell proliferation and differentiation. The cancerous tissues and adjacent non-cancerous tissues of 62 patients with osteosarcoma (OS) were collected. miRNA microarray analysis revealed that 29 miRNAs were upregulated while 26 were downregulated, among which miR-499a-5p expression was the most decreased...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29440672/linc01088-inhibits-tumorigenesis-of-ovarian-epithelial-cells-by-targeting-mir-24-1-5p
#3
Weijiang Zhang, Jing Fei, Shuqian Yu, Jiayu Shen, Xiaoqing Zhu, Annapurna Sadhukhan, Weiguo Lu, Jianwei Zhou
The roles of long non-coding RNAs (lncRNAs), a class of long non-protein-coding RNAs, in the tumorigenesis of ovarian epithelial cells remain unknown. In this study, we discovered that the expression of long intergenic non-coding RNA 1088 (LINC01088) was clearly reduced in benign epithelial ovarian tumor tissues compared to matched normal ovarian tissues. This was shown by global cDNA gene chip scanning and real-time qPCR, and validated in 42 clinical specimens. Furthermore, we found that LINC01088 inhibited the growth of ovarian cancer xenografts in nude mice...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331104/inhibition-of-mircorna-34a-enhances-survival-of-human-bone-marrow-mesenchymal-stromal-stem-cells-under-oxidative-stress
#4
Yang Liu, Xiaohu Zhang, Jie Chen, Tingyu Li
BACKGROUND Mesenchymal stromal/stem cells (MSCs) are broadly used for many diseases, but the efficacy of MSC engraftment is very low due to low viability and high cell death rate under a stressful microenvironment. The present study aimed to investigate whether microRNA-34a (miR-34a), which is a downstream target of P53, is involved in H2O2-induced MSC cell death. MATERIAL AND METHODS Human bone marrow MSCs (hMSCs) were purchased from Lonza and were cultured as previously described. hMSCs were transfected with miR-34a inhibitor and exposed to H2O2...
January 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29330462/mir-143-3p-inhibits-the-proliferation-migration-and-invasion-in-osteosarcoma-by-targeting-fosl2
#5
Xiangran Sun, Guo Dai, Ling Yu, Qingzhu Hu, Jingteng Chen, Weichun Guo
Osteosarcoma (OS) is the most common type of primary malignant bone tumor and mainly occurs in children and adolescent. Because of its early migration and invasion, OS has a poor prognosis. It has been reported that mircoRNAs (miRNAs) play a crucial role in the occurrence and development of multiple tumors. In this study, we identified the aberrant-expression of miR-143-3p in osteosarcoma and examined the role of miR-143-3p in OS development. Further, we searched the miR-143-3p target gene and verified its accuracy by luciferase experiments...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315646/microrna-21-bridging-binge-drinking-and-cardiovascular-health
#6
Yingmei Zhang, Jun Ren
No abstract text is available yet for this article.
April 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29207151/long-non%C3%A2-coding-nuclear-paraspeckle-assembly-transcript-1-acts-as-prognosis-biomarker-and-increases-cell-growth-and-invasion-in-cervical-cancer-by-sequestering-microrna%C3%A2-101
#7
Li Wang, Hongying Zhu
Emerging studies have focused on the essential role of long non‑coding RNAs (lncRNAs) in cervical carcinogenesis. A recent study has indicated that nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in the human cervical tissue. However, whether NEAT1 is involved in cervical cancer remains to be elucidated. Reverse transcription‑quantitative polymerase chain reaction results demonstrated that the expression of NEAT1 was higher in cervical cancer cells/tissues compared with that in normal human keratinocytes/tissues...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29173767/identification-of-a-serum-microrna-expression-signature-for-detection-of-lung-cancer-involving-mir-23b-mir-221-mir-148b-and-mir-423-3p
#8
Ying Zhu, Tao Li, Gang Chen, Guifang Yan, Xiaojing Zhang, Ying Wan, Qijing Li, Bo Zhu, Wenlei Zhuo
OBJECTIVES: Serum mircoRNAs (miRNAs), with their noticeable stability and unique expression pattern in patients with various diseases, are powerful novel non-invasive biomarkers for cancer detection. The objective of this study was to identify specific serum miRNAs as potential diagnostic markers for detection of lung cancer. MATERIALS AND METHODS: The expression of serum miRNA from treatment-naive lung cancer patients (LC), benign pulmonary disease patients (PD) and healthy controls (HC) were examined by PCR array...
December 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29090700/averrhoa-carambola-free-phenolic-extract-ameliorates-nonalcoholic-hepatic-steatosis-by-modulating-mircorna-34a-mircorna-33-and-ampk-pathways-in-leptin-receptor-deficient-db-db-mice
#9
Daorui Pang, Lijun You, Lin Zhou, Tong Li, Bisheng Zheng, Rui Hai Liu
The objective of the present study is to investigate the hepatic steatosis relieving effect of Averrhoa carambola free phenolic extract (ACF) on leptin receptor-deficient (db/db) mice and elucidate the modulation hepatic lipogenesis mechanisms. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) assays, accompanying hematoxylin and eosin (H&E) staining, were applied to identify the alleviation of liver histopathological changes. Serum and hepatic lipid assays, combined with oil red O staining, were used to investigate the amelioration of lipid accumulation...
December 13, 2017: Food & Function
https://www.readbyqxmd.com/read/29055260/swimming-exercise-reverses-cums-induced-changes-in-depression-like-behaviors-and-hippocampal-plasticity-related-proteins
#10
Weina Liu, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi
BACKGROUND: Stress-induced failed resilience of brain plasticity can contribute to the onset and recurrence of depression. Chronic stress has been reported to open windows of epigenetic plasticity in hippocampus. However, how hippocampal plasticity underlies depression-like behaviors and how it adapts in response to stress has not been addressed. The present study aimed to investigate the signaling mechanisms of CUMS affecting hippocampal plasticity-related proteins expression and the regulation of swimming exercise in mice...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28680530/mir-let7a-controls-the-cell-death-and-tight-junction-density-of-brain-endothelial-cells-under-high-glucose-condition
#11
Juhyun Song, So Ra Yoon, Oh Yoen Kim
Hyperglycemia-induced stress in the brain of patients with diabetes triggers the disruption of blood-brain barrier (BBB), leading to diverse neurological diseases including stroke and dementia. Recently, the role of microRNA becomes an interest in the research for deciphering the mechanism of brain endothelial cell damage under hyperglycemia. Therefore, we investigated whether mircoRNA Let7A (miR-Let7A) controls the damage of brain endothelial (bEnd.3) cells against high glucose condition. Cell viability, cell death marker expressions (p-53, Bax, and cleaved poly ADP-ribose polymerase), the loss of tight junction proteins (ZO-1 and claudin-5), proinflammatory response (interleukin-6, tumor necrosis factor-α), inducible nitric oxide synthase, and nitrite production were confirmed using MTT, reverse transcription-PCR, quantitative-PCR, Western blotting, immunofluorescence, and Griess reagent assay...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28562533/mirnas-as-biomarkers-for-diagnosis-of-heart-failure-a-systematic-review-and-meta-analysis
#12
REVIEW
Hualin Yan, Fan Ma, Yi Zhang, Chuan Wang, Dajian Qiu, Kaiyu Zhou, Yimin Hua, Yifei Li
BACKGROUND: With the rapid development of molecular biology, the kind of mircoRNA (miRNA) has been introduced into emerging role both in cardiac development and pathological procedure. Thus, we conduct this meta-analysis to find out the role of circulating miRNA as a biomarker in detecting heart failure. METHODS: We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and World Health Organization clinical trials registry center to identify relevant studies up to August 2016...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28250135/circulating-mircorna-21-as-a-predictor-for-vascular-restenosis-after-interventional-therapy-in-patients-with-lower-extremity-arterial-occlusive-disease
#13
Bo Zhang, Ye Yao, Qing-Feng Sun, Si-Qi Liu, Bao Jing, Chao Yuan, Xin-Yu Liu, Tong Jiao, Hao-Cheng Li, Hai-Yang Wang
The present study was designed to investigate the role of circulating miRNA-21 ( miR-21 ) in vascular restenosis of lower extremity arterial occlusive disease (LEAOD) patients after interventional therapy. A total of 412 LEAOD patients were enrolled randomly in the present study. According to computed tomography angiography (CTA) and ankle-brachial index (ABI), patients were assigned into the restenosis group and the non-restenosis group. miR-21 expression was detected with quantitative real-time PCR (qRT-PCR) before and after patients underwent interventional therapy...
April 30, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28116173/electroacupuncture-regulates-hippocampal-synaptic-plasticity-via-mir-134-mediated-limk1-function-in-rats-with-ischemic-stroke
#14
Weilin Liu, Jie Wu, Jia Huang, Peiyuan Zhuo, Yunjiao Lin, Lulu Wang, Ruhui Lin, Lidian Chen, Jing Tao
MircoRNAs (miRs) have been implicated in learning and memory, by regulating LIM domain kinase (LIMK1) to induce synaptic-dendritic plasticity. The study aimed to investigate whether miRNAs/LIMK1 signaling was involved in electroacupuncture- (EA-) mediated synaptic-dendritic plasticity in a rat model of middle cerebral artery occlusion induced cognitive deficit (MICD). Compared to untreatment or non-acupoint-EA treatment, EA at DU20 and DU24 acupoints could shorten escape latency and increase the frequency of crossing platform in Morris water maze test...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28091538/mircorna-145-promotes-activation-of-hepatic-stellate-cells-via-targeting-kr%C3%A3-ppel-like-factor-4
#15
Ruoting Men, Maoyao Wen, Mingyue Zhao, Xuelian Dan, Zongze Yang, Wenchao Wu, Maggie Haitian Wang, Xiaojing Liu, Li Yang
Krüppel-like Factor 4 (KLF4), a target gene of miR-145, can negatively regulate lung fibrosis. However, the potential role of KLF4 and miR-145 in hepatic stellate cells (HSCs) activation or in hepatic fibrosis keeps unclear. This study aims to characterize miR-145 and KLF4 in activated HSCs and liver cirrhotic, and the underlying molecular basis. miR-145 was significantly up-regulated, while KLF4 was dramatically down-regulated during the activation of rat primary HSCs and TGF-βtreated HSCs. Furthermore, miR-145 mimics induced and inhibition of miR-145 reduced α-SMA and COL-I expression in primary HSCs...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074870/microrna-155-is-upregulated-in-ascites-in-patients-with-spontaneous-bacterial-peritonitis
#16
Philipp Lutz, Mohamed M Haimid, Alessandra Pohlmann, Jennifer Lehmann, Christian Jansen, Robert Schierwagen, Sabine Klein, Christian P Strassburg, Ulrich Spengler, Jonel Trebicka
MircoRNA's (miR) have been recognised as important modulators of gene expression and potential biomarkers. However, they have been rarely investigated in bio fluids apart from blood. We investigated the association of miR-125b and miR-155 with complications of cirrhosis. Ascites was prospectively collected from patients with cirrhosis undergoing paracentesis at our department. miR's were determined in the supernatant using qPCR and normalized by SV-40. Clinical parameters were assessed at paracentesis and during follow-up...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070856/mir-29c-prkci-regulates-axonal-growth-of-dorsal-root-ganglia-neurons-under-hyperglycemia
#17
Longfei Jia, Lei Wang, Michael Chopp, Chao Li, Yi Zhang, Alexandra Szalad, Zheng Gang Zhang
Diabetes initially induces distal axonal damage of peripheral nerves, but molecular mechanisms that mediate axonal injury are not fully understood. MircoRNAs (miRNAs) regulate axonal growth. We found that diabetic db/db mice exhibited substantial upregulation of miR-29c in dorsal root ganglia (DRG) neurons, sciatic nerve, and foot pad tissues. Bioinformatic analysis revealed PRKCI, a gene that encodes a member of the protein kinase C (PKC) iota, as a putative target for miR-29c. Western blot analysis showed that diabetic mice exhibited a considerable reduction of PRKCI protein levels in sciatic nerve tissues and DRG neurons...
January 9, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/27893417/genetic-and-epigenetic-silencing-of-mircorna-506-3p-enhances-cotl1-oncogene-expression-to-foster-non-small-lung-cancer-progression
#18
Shanqi Guo, Peiying Yang, Xingkang Jiang, Xiaojiang Li, Yuanyuan Wang, Xin Zhang, Binxu Sun, Yao Zhang, Yingjie Jia
Although previous studies suggested that microRNA-506-3p (miR-506-3p) was frequently downregulated, and functioned as a tumor suppressor in several cancers, the biological role and intrinsic regulatory mechanisms of miR-506-3p in non-small cell lung cancer (NSCLC) remain elusive. The present study found miR-506-3p expression was downregulated in advanced NSCLC tissues and cell lines. The expression of miR-506-3p in NSCLC was inversely correlated with larger tumor size, advanced TNM stage and lymph node metastasis...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27802900/downregulation-of-mir-181a-protects-mice-from-lps-induced-acute-lung-injury-by-targeting-bcl-2
#19
Wuquan Li, Xiaochen Qiu, He Jiang, Yalong Han, Dinan Wei, Jun Liu
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a progressive syndrome with a high incidence and mortality rate. Apoptosis is a very important pathological feature of ALI. Recently, more and more researches on mircoRNAs are involved in the regulation of proliferation and apoptosis of cancer cells. However, the functions of microRNAs in ALI remain unknown. In this study, PCR array and qRT-PCR were used to investigate microRNA profiles and miR-181a regulates apoptosis induced by LPS. Then, we predict the potential target gene of miR-181a is BCL-2 by bioinformatics methods, and validate it using luciferase reporter gene assays...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27789576/the-role-and-regulation-of-rab40b-tks5-complex-during-invadopodia-formation-and-cancer-cell-invasion
#20
Abitha Jacob, Erik Linklater, Brian A Bayless, Traci Lyons, Rytis Prekeris
Invadopodia formation and extracellular matrix degradation are key events during cancer cell invasion, yet little is known about mechanisms mediating these processes. Here, we report that Rab40b plays a key role in mediating invadopodia function during breast cancer cell invasion. We also identify Tks5 (also known as SH3PXD2A), a known Src kinase substrate, as a new Rab40b effector protein and show that Tks5 functions as a tether that mediates Rab40b-dependent targeting of transport vesicles containing MMP2 and MMP9 to the extending invadopodia...
December 1, 2016: Journal of Cell Science
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