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https://www.readbyqxmd.com/read/28642096/pine-needle-extract-prevents-hippocampal-memory-impairment-in-acute-restraint-stress-mouse-model
#1
Jin-Seok Lee, Hyeong-Geug Kim, Hye-Won Lee, Won-Yong Kim, Yo-Chan Ahn, Chang-Gue Son
ETHNOPHARMACOLOGICAL RELEVANCE: The Pinus densiflora leaf has been traditionally used to treat mental health disorders as a traditional Chinese medicine. Here we examined the ethnopharmacological relevance of pine needle on memory impairment caused by stress. AIM OF THE STUDY: To elucidate the possible modulatory actions of 30% ethanolic pine needle extract (PNE) on stress-induced hippocampal excitotoxicity, we adopted an acute restraint stress mouse model. MATERIALS AND METHODS: Mice were orally administered with PNE (25, 50, or 100mg/kg) or ascorbic acid (100mg/kg) for 9 days, and were then subjected to restraint stress (6h/day) for 3 days (from experimental day 7 to 9)...
June 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28642028/discovery-of-novel-5-oxa-2-6-diazaspiro-3-4-oct-6-ene-derivatives-as-potent-selective-and-orally-available-somatostatin-receptor-subtype-5-sstr5-antagonists-for-treatment-of-type-2-diabetes-mellitus
#2
Hideki Hirose, Takeshi Yamasaki, Masaki Ogino, Ryo Mizojiri, Yumiko Tamura-Okano, Hiroaki Yashiro, Yo Muraki, Yoshihide Nakano, Jun Sugama, Akito Hata, Shinji Iwasaki, Masanori Watanabe, Tsuyoshi Maekawa, Shizuo Kasai
Somatostatin receptor subtype 5 (SSTR5) has emerged as a novel attractive drug target for type 2 diabetes mellitus. Starting from N-benzyl azetidine derivatives 1 and 2 as in-house hit compounds, we explored the introduction of a carboxyl group into the terminal benzene of 1 to enhance SSTR5 antagonistic activity by the combination of the substituents at the 3-position of the isoxazoline. Incorporation of a carboxyl group at the 4-position of the benzene ring resulted in a significant enhancement in potency, however, the 4-benzoic acid derivative 10c exhibited moderate human ether-a-go-go related gene (hERG) inhibitory activity...
June 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28639750/protein-lysine-methyltransferase-smyd3-is-involved-in-tumorigenesis-through-regulation-of-her2-homodimerization
#3
Yuichiro Yoshioka, Takehiro Suzuki, Yo Matsuo, Giichiro Tsurita, Toshiaki Watanabe, Naoshi Dohmae, Yusuke Nakamura, Ryuji Hamamoto
HER2 is a receptor tyrosine kinase, which is amplified and overexpressed in a subset of human cancers including breast and gastric cancers, and is indicated in its involvement in progression of cancer. Although its specific ligand(s) has not been detected, HER2 homodimerization, which is critical for its activation, is considered to be dependent on its expression levels. Here, we demonstrate a significant role of HER2 methylation by protein lysine methyltransferase SMYD3 in HER2 homodimerization. We found that SMYD3 trimethylates HER2 protein at lysine 175...
June 22, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28639444/comparison-of-shuttle-and-straight-repeated-sprint-ability-tests-and-their-relationship-to-anthropometrics-and-explosive-muscular-performance-of-lower-limb-in-elite-handball-players
#4
Souhail Hermassi, René Schwesig, Rainer Wollny, Georg Fieseler, Roland van den Tillaar, Jaime Fernandez-Fernandez, Roy J Shephard, Mohamed S Chelly
BACKGROUND: This study assessed inter-relationships between shuttle and straight repeated-sprint ability tests and the relationship of each measure to anthropometric and explosive lower limb performance data in elite handball players. METHODS: Twenty-two elite male handball players (18.9 ± 0.2 years; body mass: 83.3 ± 1.1 kg, height: 1.79 ± 2.30 m, body fat: 12.8 ± 0.2%) completed tests that included a lower limb force-velocity test of peak power (Wpeak), jumping ability (squat and counter-movement jumps; SJ, CMJ), 1 repetition maximum (1-RM) half back squat, average sprint velocity over 5 m (V-5 m), peak velocity between 25-30 m (Vmax), and Yo-Yo Intermittent Recovery Test level 1 (Yo-Yo IR1), and anthropometric determinations of cross-sectional areas and muscle volumes for leg and thigh muscles...
June 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28639443/relationship-between-the-handball-specific-complex-test-nonspecific-field-tests-and-the-match-performance-score-in-elite-professional-handball-players
#5
Souhail Hermassi, Mohamed S Chelly, Rainer Wollny, Birgit Hoffmeyer, Georg Fieseler, Stephan Schulze, Lars Irlenbusch, Karl-Stefan Delank, Roy J Shephard, Thomas Bartels, René Schwesig
BACKGROUND: This study assessed the validity of the handball-specific complex-test (HBCT) and two nonspecific field tests in professional elite handball athletes, using the match performance score (MPS) as the gold standard of performance. METHODS: Thirteen elite male handball players (age: 27.4 ± 4.8 years; premier German league) performed the HBCT, the Yo-Yo Intermittent Recovery Test (Yo-Yo-IR1-test) and a repeated shuttle sprint ability (RSA) test at the beginning of pre-season training...
June 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28637563/postoperative-neutrophil-to-lymphocyte-ratio-as-a-predictor-of-long-term-prognosis-after-pancreatectomy-for-pancreatic-carcinoma-a-retrospective-analysis
#6
Eiji Tsujita, Yasuharu Ikeda, Nao Kinjo, Yo-Ichi Yamashita, Terumasa Hisano, Masayuki Furukawa, Ken-Ichi Taguchi, Masaru Morita, Yasushi Toh, Takeshi Okamura
To clarify the prognostic value of the postoperative blood neutrophil-to-lymphocyte ratio (NLR) in patients undergoing pancreatectomy for pancreatic carcinoma (PAC). A high preoperative NLR has been reported to be a predictor of poor survival in patients with various cancers including PAC. However, it has not been extensively examined in postoperative NLR after pancreatectomy for PAC. This retrospective study enrolled 86 patients who underwent pancreatectomy without preoperative therapy for PAC from 2005 to 2013...
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28634823/a-nationwide-study-of-the-incidence-rate-of-herb-induced-liver-injury-in-korea
#7
Jung-Hyo Cho, Dal-Seok Oh, Sang-Hoon Hong, Heung Ko, Nam-Hun Lee, Sang-Eun Park, Chang-Woo Han, Seung-Mo Kim, Young-Chul Kim, Kang-San Kim, Chang-Won Choi, Seon-My Shin, Ki-Tae Kim, Hong-Sik Choi, Jang-Hoon Lee, Jun-Young Kim, Ji-Young Kang, Dong-Soo Lee, Yo-Chan Ahn, Chang-Gue Son
Discrepant incidence has been reported regarding the incidence of herb-induced liver injury (HILI). To address the growing worldwide concern of HILI, we evaluated the risk of HILI in a nationwide prospective study. Between April 2013 and January 2016, 1001 inpatients (360 males and 641 females) from 10 tertiary hospitals throughout South Korea were treated with herbal drugs and had their liver enzymes periodically measured. A total of six patients met the criteria for HILI with RUCAM scores ranging from 4 to 7...
June 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28633434/psip1-p75-promotes-tumorigenicity-in-breast-cancer-cells-by-promoting-the-transcription-of-cell-cycle-genes
#8
Deepak K Singh, Omid Gholamalamdari, Mahdieh Jadaliha, Xiao Ling Li, Yo-Chuen Lin, Yang Zhang, Shuomeng Guang, Seyedsasan Hashemikhabir, Saumya Tiwari, Yuelin J Zhu, Abid Khan, Anu Thomas, Arindam Chakraborty, Virgilia Macias, Andre K Balla, Rohit Bhargava, Sarath Chandra Janga, Jian Ma, Supriya G Prasanth, Ashish Lal, Kannanganattu V Prasanth
Breast cancer (BC) is a highly heterogeneous disease, both at the pathological and molecular level, and several chromatin-associated proteins play crucial roles in breast cancer initiation and progression. Here, we demonstrate the role of PSIP1 (PC4 and SF2 interacting protein)/p75 (LEDGF) in breast cancer progression. PSIP1/p75, previously identified as a chromatin-adaptor protein, is found to be upregulated in basal-like/triple negative breast cancer (TNBC) patient samples and cell lines. Immunohistochemistry in tissue arrays showed elevated levels of PSIP1 in metastatic invasive ductal carcinoma...
June 17, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28629578/endobronchial-squamous-cell-carcinoma-presenting-as-localized-long-continuous-bronchial-thickening-on-ct
#9
Yoonah Song, Yo Won Choi, Seung Sam Paik, Dae Hee Han, Kyo Young Lee
OBJECTIVE: To report pulmonary squamous cell carcinomas presenting as localized, long, continuous, bronchial thickening on computed tomography (CT). MATERIALS AND METHODS: This study comprised five men (mean age, 66 years; range, 60-79 years) with pulmonary squamous cell carcinoma, including two (0.6%) selected from 310 consecutive patients with the diagnosis. Inclusion criteria were as follows: histological diagnosis obtained from thickened bronchi; continuous bronchial thickening >5cm in longitudinal extension on CT...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28623450/the-relationship-between-excitement-symptom-severity-and-extrastriatal-dopamine-d2-3-receptor-availability-in-patients-with-schizophrenia-a-high-resolution-pet-study-with-18-f-fallypride
#10
Yo-Han Joo, Jeong-Hee Kim, Young-Don Son, Hang-Keun Kim, Yeon-Jeong Shin, Sang-Yoon Lee, Jong-Hoon Kim
The purpose of this study was to investigate the relationship between specific symptom severity and D2/3 receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixteen schizophrenia patients receiving relatively low-dose maintenance atypical antipsychotics and seventeen healthy controls underwent 3-Tesla magnetic resonance imaging and high-resolution positron emission tomography with [(18)F]fallypride...
June 16, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28616989/reconstructed-serine288-in-the-left-flipper-region-of-rat-p2x7-receptor-stabilizes-non-sensitized-states
#11
Yevheniia Ishchenko, Nataliia Novosolova, Kamil Khafizov, Genevieve Bart, Arina Timonina, Dmitriy Fayuk, Andrei Skorinkin, Rashid Giniatullin
Serine 275, a conserved residue of the left flipper region of ATP-gated P2X3 receptors, plays a key role in both agonist binding and receptor desensitization. It is conserved in most of the P2X receptors except P2X7 and P2X6. By combining experimental patch-clamp and modelling approaches, we explored the role of the corresponding residue in rat P2X7 receptor (rP2X7) by replacing phenylalanine in the position 288 with serine and characterizing the membrane currents generated by either WT or mutated rP2X7 receptor...
June 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/28613960/the-effect-of-air-pollution-on-diurnal-variation-of-performance-in-anaerobic-tests-cardiovascular-and-hematological-parameters-and-blood-gases-on-soccer-players-following-the-yo-yo-intermittent-recovery-test-level-1
#12
Nesrin Boussetta, Salma Abedelmalek, Khouloud Aloui, Nizar Souissi
This study aimed to investigate the effect of air pollution on diurnal variation of performance in anaerobic tests, cardiovascular and hematological parameters, and blood gases on soccer players following the Yo-Yo Intermittent Recovery Test Level-1 (YYIRT1). In a randomized order, 11 healthy soccer players (mean age: 21.8 [range: 20-24] years; height: 178.00 [range: 1.64-1.83] cm; body mass index [BMI]: 23.57 [range: 20.45-28.03] kg.m(-2)) performed a YYIRT1 at two different times of day (TOD) (08:00 h and 18:00 h) in two areas (i...
June 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28612915/how-to-predict-the-risk-of-postoperative-complications-after-coronary-artery-bypass-grafting-in-patients-under-50-and-over-80-years-old-a-retrospective-cross-sectional-study
#13
Jacek Piątek, Anna Kędziora, Grzegorz Kiełbasa, Marta Olszewska, Dorota Sobczyk, Bryan HyoChan Song, Janusz Konstanty-Kalandyk, Tomasz Darocha, Karol Wierzbicki, Irena Milaniak, Krzysztof Wróbel, Bogusław Kapelak
BACKGROUND: Coronary artery disease (CAD) remains the leading cause of death in developed countries and there is an increasing number of both young and elderly patients requiring surgical treatment. Despite improvement of conventional risk stratification scores (EuroSCORE II, STS risk score), all of the calculations are estimated based on the typical population and the studies emphasize that the scales may need further investigation and modernization, as demographic changes of the population suffering from CAD are unavoidable...
June 14, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28607290/technique-of-totally-robotic-delta-shaped-anastomosis-in-distal-gastrectomy
#14
Hidehiko Kitagami, Keisuke Nonoyama, Akira Yasuda, Yo Kurashima, Kaori Watanabe, Shiro Fujihata, Minoru Yamamoto, Yasunobu Shimizu, Moritsugu Tanaka
BACKGROUND: We aimed to clarify the utility of delta-shaped anastomosis (Delta), an intracorporeal Billroth-I anastomosis-based reconstruction technique used after laparoscopy-assisted distal gastrectomy (LADG), in robot-assisted distal gastrectomy (RADG). METHODS: RADG was performed in patients with clinical Stage I gastric cancer, and reconstruction was performed using Delta. The Delta procedure was the same as that performed after LADG, and the operator practiced the procedure in simulated settings with surgical assistants before the operation...
July 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28604286/growth-functional-capacities-and-motivation-for-achievement-and-competitiveness-in-youth-basketball-an-interdisciplinary-approach
#15
Humberto Moreira Carvalho, Carlos E Gonçalves, Dave Collins, Roberto R Paes
The interaction of multiple influences on the path to sport success is not yet fully understood by sport scientists. In this study, we examined variation in body size, functional capacities and motivation for achievement, competitiveness and deliberate practice of youth basketball players associated with differences in biological maturity status, chronological age and years of training experience. Reflecting the importance of interactive effects, we examined the relationships between the psychological variables and functional capacities...
June 12, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28593801/renal-dysfunction-indicative-of-outcomes-in-hospitalized-patients-with-takotsubo-syndrome
#16
Kaoru Ando, Hiroyasu Sukekawa, Aoi Takahata, Yusuke Kobari, Hayato Tsuchiya, Daisuke Ishigaki, Toshiaki Tamabuchi, Yo Koyama
BACKGROUND: Left ventricular dysfunction as part of takotsubo syndrome is reversible, and the long-term prognosis appears favorable. However, life-threatening complications are not uncommon during the acute phase, and it remains unclear whether renal dysfunction is a factor in complications suffered by hospitalized patients with takotsubo syndrome. The present study was conducted to investigate the implications of renal dysfunction in this setting. METHODS: Data from 61 consecutive patients (male, 21; female, 40) diagnosed with takotsubo syndrome at our hospital between years 2010 and 2016 were evaluated retrospectively...
June 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28591112/the-promise-of-organ-and-tissue-preservation-to-transform-medicine
#17
Sebastian Giwa, Jedediah K Lewis, Luis Alvarez, Robert Langer, Alvin E Roth, George M Church, James F Markmann, David H Sachs, Anil Chandraker, Jason A Wertheim, Martine Rothblatt, Edward S Boyden, Elling Eidbo, W P Andrew Lee, Bohdan Pomahac, Gerald Brandacher, David M Weinstock, Gloria Elliott, David Nelson, Jason P Acker, Korkut Uygun, Boris Schmalz, Brad P Weegman, Alessandro Tocchio, Greg M Fahy, Kenneth B Storey, Boris Rubinsky, John Bischof, Janet A W Elliott, Teresa K Woodruff, G John Morris, Utkan Demirci, Kelvin G M Brockbank, Erik J Woods, Robert N Ben, John G Baust, Dayong Gao, Barry Fuller, Yoed Rabin, David C Kravitz, Michael J Taylor, Mehmet Toner
The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities...
June 7, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28590332/hiv-positive-youth-who-are-perinatally-infected-have-impaired-endothelial-function
#18
Sahera Dirajlal-Fargo, Abdus Sattar, Manjusha Kulkarni, Emily Bowman, Nicholas Funderburg, Grace A Mccomsey
OBJECTIVE: Evaluating cardiovascular (CVD) risk in children and youth 13-24 years old who are facing a life time exposure to both HIV and antiretroviral therapy (ART) is a research priority. This study compares endothelial function measured by Peripheral Arterial Tonometry in HIV+ youth infected perinatally and behaviorally as well as HIV- controls. METHODS: Three groups of participants aged 8-30 yo were enrolled; HIV+ perinatally-infected, HIV+ behaviorally-infected on ART with HIV-1 RNA <1,000 copies/mL, and HIV- controls...
June 5, 2017: AIDS
https://www.readbyqxmd.com/read/28583598/detection-of-macrophages-in-rabbit-semen-and-their-relationship-with-semen-quality
#19
Lenka Kuželová, Jaromír Vašíček, Ján Rafay, Peter Chrenek
We aimed at the evaluating the occurrence of macrophages in rabbit semen and finding possible relationship between macrophage concentration and spermatozoa quality. The concentration of macrophages in semen samples from broiler rabbit males of lines M91 and P91 (n = 30) without overt evidence of genital tract infections was determined using monocyte/macrophage lineage antigen CD14 and flow cytometry. Then the rabbits were assigned into three groups according to the macrophage concentration in semen (MΦ1 group with less than 1 × 10(6) macrophages/mL, MΦ2 group with 1...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28581445/glutamine-supplementation-suppresses-herpes-simplex-virus-reactivation
#20
Kening Wang, Yo Hoshino, Kennichi Dowdell, Marta Bosch-Marce, Timothy G Myers, Mayra Sarmiento, Lesley Pesnicak, Philip R Krause, Jeffrey I Cohen
Chronic viral infections are difficult to treat, and new approaches are needed, particularly those aimed at reducing reactivation by enhancing immune responses. Herpes simplex virus (HSV) establishes latency and reactivates frequently, and breakthrough reactivation can occur despite suppressive antiviral therapy. Virus-specific T cells are important to control HSV, and proliferation of activated T cells requires increased metabolism of glutamine. Here, we found that supplementation with oral glutamine reduced virus reactivation in latently HSV-1-infected mice and HSV-2-infected guinea pigs...
June 5, 2017: Journal of Clinical Investigation
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