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https://www.readbyqxmd.com/read/29329155/ecological-validity-and-reliability-of-an-age-adapted-endurance-field-test-in-young-male-soccer-players
#1
Carlo Castagna, Peter Krustrup, Stefano D'Ottavio, Carlo Pollastro, Andrea Bernardini, Susana Cristina Araújo Póvoas
The purpose of this study was to examine the reliability and the association with relevant match activities (ecological validity) of an age-adapted field test for intermittent high-intensity endurance known as Yo-Yo intermittent recovery level 1 children test (YYIR1C) in young male soccer players. Twenty-eight young male outfield soccer players (age 11.1±0.9 years, height 142±4.4 cm, body mass 37.0±5.9 kg) with at least 2 years of experience in soccer competitions were tested twice using YYIR1C and an age-adapted competitive small-sided game (i...
January 11, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29324401/unblinded-randomized-multicenter-trial-comparing-lamotrigine-and-valproate-combination-with-controlled-release-carbamazepine-monotherapy-as-initial-drug-regimen-in-untreated-epilepsy
#2
Byung In Lee, Soon Kee No, Sang-Doe Yi, Hyang Woon Lee, Ok Joon Kim, Sang Ho Kim, Myeong Kyu Kim, Sung Eun Kim, Yo Sik Kim, Jae Moon Kim, Se-Jin Lee, Dong Jin Shin, Sung Pa Park, Yeong In Kim, Kyoung Heo, Yong Won Cho, Yang-Je Cho, Youn Nam Kim
PURPOSE: To compare controlled-release carbamazepine monotherapy (CBZ-CR) with lamotrigine and valproate combination therapy (LTG + VPA) in equivalent total drug load, as initial drug regimen in untreated patients with partial and/or generalized tonic-clonic seizures (GTCS). METHODS: This unblinded, randomized, 60-week superiority trial recruited patients having two or more unprovoked seizures with at least one seizure during previous three months. After randomization into CBZ-CR or LTG + VPA, patients entered into eight-week titration phase (TP), followed by 52-week maintenance phase (MP)...
December 29, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29319776/hypercalcemia-and-acute-renal-insufficiency-following-use-of-a-veterinary-supplement
#3
Marcelo Fernando Ronsoni, Heloisa de Cassia Dos Santos, Bruno da Silveira Colombo, Carina Gabriela Correa, Ana Paula Gomes Moritz, Marisa Helena Cesar Coral, Simone Van de Sande-Lee, Alexandre Hohl
A previously healthy 24 yo male presented with a two-month history of epigastric pain, nausea, vomiting, fatigue and malaise. He reported abuse of different substances, including an injectable veterinary vitamin compound, which contains high doses of vitamin A, D and E, and an oily vehicle that induces local edema and enhances muscle volume. Serum creatinine was 3.1 mg/dL, alanine transaminase 160 mg/dL, aspartate transaminase 11 mg/dL, total testosterone 23 ng/dL, 25-OH-vitamin D >150 ng/mL (toxicity >100), 1,25-OH-vitamin D 80 pg/mL, vitamin A 0...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29311495/fluorescent-imaging-analysis-for-distribution-of-fluorescent-dye-labeled-or-encapsulated-liposome-in-monocrotaline-induced-pulmonary-hypertension-model-rat
#4
Yo Muraki, Midori Yamasaki, Hirohisa Takeuchi, Kimio Tohyama, Noriyasu Sano, Takanori Matsuo
Pulmonary hypertension (PH) is a life-threatening lung disease. Despite the availability of several approved drugs, the development of a new treatment method is needed because of poor prognosis. Tissue selective drug delivery systems can avoid the adverse effects of current therapy and enhance efficacy. We evaluated the possibility of delivering drugs to the lungs of a PH rat model using fluorescence dye-labeled nanosized liposomes. To evaluate the tissue distribution following systemic exposure, fluorescent dye-labeled, 40-180 nm liposomes with and without polyethylene glycol (PEG) were intravenously administered to a monocrotaline-induced PH (MCT) rat model and tissue fluorescence was measured...
January 6, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29306402/complex-hla-association-in-paraneoplastic-cerebellar-ataxia-with-anti-yo-antibodies
#5
Ryan P Hillary, Hanna M Ollila, Ling Lin, Virginie Desestret, Veronique Rogemond, Geraldine Picard, Mathilde Small, Isabelle Arnulf, Yves Dauvillers, Jerome Honnorat, Emmanuel Mignot
Anti-Yo paraneoplastic cerebellar degeneration (PCD) is a devastating autoimmune complication of gynecological cancers. We hypothesized that as for other autoimmune diseases, specific HLA haplotypes are associated. We conducted high resolution HLA typing of Class I/Class II in 40 cases versus ethnically matched controls. Three cases with anti-Yo antibodies and peripheral neuropathy were also included. We detected protective effects of DPA1*01:03~DPB1*04:01 (OR=0, p=0.0008), DRB1*04:01~DQA1*03:03(OR=0, p=0.0016) and DPA1*01:03~DPB1*04:01 (OR=0...
February 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29301000/developmental-defects-associated-with-dna-copy-number-gain-of-chromosome-2q33-1-a-case-report-and-review-of-literature
#6
Akshaya Gupta, Jacob Yo, Gengming Huang, Lynn Soong, Jianli Dong
Caspases play a vital role during apoptosis. In addition to apoptosis, caspases play a role in cytokine gene induction and work to inhibit apoptosis. In order for individuals to thrive with useful tissue growth, the rate of cell growth and division must surpass the rate of cell division. It is well established that excessive cell death of embryonic cells is a vital process occurring before structural abnormalities, regardless of their nature. Here we describe a 13-month-old male patient with a 4.7Mb interstitial duplication of chromosome 2q33...
December 29, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29299708/hepatic-sclerosed-hemangioma-with-special-attention-to-diffusion-weighted-magnetic-resonance-imaging
#7
Tatsunori Miyata, Toru Beppu, Kunitaka Kuramoto, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Tomohiro Namimoto, Yo-Ichi Yamashita, Akira Chikamoto, Yasuyuki Yamashita, Hideo Baba
BACKGROUND: A hepatic sclerosed hemangioma (HSH) is a very rare benign liver tumor. The correct preoperative diagnosis of HSH is very difficult because its features of imaging are similar to those of intrahepatic cholangiocarcinoma or colorectal liver metastasis. CASE PRESENTATION: We experienced five patients who were diagnosed histologically with HSH. The preoperative diagnoses were HSH in two patients, cavernous hemangioma in one, intrahepatic cholangiocarcinoma in one, and colorectal liver metastasis in one...
January 3, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29299667/genetic-alterations-and-tumor-immune-attack-in-yo-paraneoplastic-cerebellar-degeneration
#8
Mathilde Small, Isabelle Treilleux, Coline Couillault, Daniel Pissaloux, Géraldine Picard, Sandrine Paindavoine, Valery Attignon, Qing Wang, Véronique Rogemond, Stéphanie Lay, Isabelle Ray-Coquard, Jacobus Pfisterer, Florence Joly, Andreas Du Bois, Dimitri Psimaras, Nathalie Bendriss-Vermare, Christophe Caux, Bertrand Dubois, Jérôme Honnorat, Virginie Desestret
Paraneoplastic cerebellar degenerations with anti-Yo antibodies (Yo-PCD) are rare syndromes caused by an auto-immune response against neuronal antigens (Ags) expressed by tumor cells. However, the mechanisms responsible for such immune tolerance breakdown are unknown. We characterized 26 ovarian carcinomas associated with Yo-PCD for their tumor immune contexture and genetic status of the 2 onconeural Yo-Ags, CDR2 and CDR2L. Yo-PCD tumors differed from the 116 control tumors by more abundant T and B cells infiltration occasionally organized in tertiary lymphoid structures harboring CDR2L protein deposits...
January 3, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29298444/human-malformation-syndromes-of-defective-gli-opposite-phenotypes-of-2q14-2-gli2-and-7p14-2-gli3-microdeletions-and-a-glia-r-balance-model
#9
Yo Niida, Mika Inoue, Mamoru Ozaki, Etsuko Takase
GLI family zinc finger proteins are transcriptional effectors of the sonic hedgehog signaling pathway. GLI regulates gene expression and repression at various phases of embryonic morphogenesis. In humans, 4 GLI genes are known, and GLI2 (2q14.2) and GLI3 (7p14.1) mutations cause different syndromes. Here, we present 2 distinctive cases with a chromosomal microdeletion in one of these genes. Patient 1 is a 14-year-old girl with Culler-Jones syndrome. She manifested short stature, cleft palate, and mild intellectual/social disability caused by a 6...
January 4, 2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29296862/brafv600e-accelerates-disease-progression-and-enhances-immune-suppression-in-a-mouse-model-of-b-cell-leukemia
#10
Yo-Ting Tsai, Aparna Lakshmanan, Amy Lehman, Bonnie K Harrington, Fabienne McClanahan Lucas, Minh Tran, Ellen J Sass, Meixiao Long, Alan D Flechtner, Florinda Jaynes, Krista La Perle, Vincenzo Coppola, Gerard Lozanski, Natarajan Muthusamy, John C Byrd, Michael R Grever, David M Lucas
Mutated mitogen-activated protein kinase (MAPK) pathway components promote tumor survival, proliferation, and immune evasion in solid tumors. MAPK mutations occur in hematologic cancers as well, but their role is less clear and few models are available to study this. We developed an in vivo model of disseminated BRAFV600E B-cell leukemia to determine the effects of this mutation on tumor development and immune evasion. Mice with B-cell-restricted BRAFV600E expression crossed with the Eµ-TCL1 model of chronic lymphocytic leukemia (CLL) developed leukemia significantly earlier (median, 4...
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296720/x-ray-crystal-structure-of-plasmin-with-tranexamic-acid-derived-active-site-inhibitors
#11
Ruby H P Law, Guojie Wu, Eleanor W W Leung, Koushi Hidaka, Adam J Quek, Tom T Caradoc-Davies, Devadharshini Jeevarajah, Paul J Conroy, Nigel M Kirby, Raymond S Norton, Yuko Tsuda, James C Whisstock
The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threatening hemorrhagic disorders or thrombotic vascular occlusion. Accordingly, inhibitors of this system are clinically important. Currently, tranexamic acid (TXA), a molecule that prevents plasminogen activation through blocking recruitment to target substrates, is the most widely used inhibitor for the plasminogen/plasmin system in therapeutics...
May 9, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295864/harnessing-an-rna-mediated-chaperone-for-the-assembly-of-influenza-hemagglutinin-in-an-immunologically-relevant-conformation
#12
Seung Won Yang, Yo Han Jang, Soon Bin Kwon, Yoon Jae Lee, Wonil Chae, Young Ho Byun, Paul Kim, Chan Park, Young Jae Lee, Choon Kang Kim, Young Seok Kim, Seong Il Choi, Baik Lin Seong
A novel protein-folding function of RNA has been recognized, which can outperform previously known molecular chaperone proteins. The RNA as a molecular chaperone (chaperna) activity is intrinsic to some ribozymes and is operational during viral infections. Our purpose was to test whether influenza hemagglutinin (HA) can be assembled in a soluble, trimeric, and immunologically activating conformation by means of an RNA molecular chaperone (chaperna) activity. An RNA-interacting domain (RID) from the host being immunized was selected as a docking tag for RNA binding, which served as a transducer for the chaperna function for de novo folding and trimeric assembly of RID-HA1...
January 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29290919/cystic-metastasis-from-a-mucinous-adenocarcinoma-of-duodenum-mimicking-type-ii-choledochal-cyst-a-case-report
#13
Yo Na Kim, Ji Soo Song
A 51-year-old male patient was referred to our hospital because of an incidentally detected cystic mass near the common bile duct (CBD). Imaging studies demonstrated a cystic mass that was suspected to communicate with the CBD. Gastroscopy showed irregular mucosal thickening with hyperemic change in the second portion of the duodenum. A type II choledochal cyst combined with duodenal malignancy was suspected. The patient underwent surgical resection and the histological diagnosis was mucinous adenocarcinoma of the duodenum with cystic metastasis...
December 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29290027/n-terminal-tagging-of-human-p2x7-receptor-disturbs-calcium-influx-and-dye-uptake
#14
Karin Dreisig, Nikolaj Pagh Kristensen, Maja Wallentin Dommer, Niklas Rye Jørgensen, Birgitte Rahbek Kornum
The P2X7 receptor is a frequently studied member of the purinergic receptor family signalling via channel opening and membrane pore formation. Fluorescent imaging is an important molecular method for studying cellular receptor expression and localization. Fusion of receptors to fluorescent proteins might cause major functional changes and requires careful functional evaluation such as has been done for the rat P2X7 receptor. This study examines fusion constructs of the human P2X7 receptor. We assessed surface expression, channel opening with calcium influx, and pore formation using YO-PRO-1 dye uptake in response to BzATP stimulation in transfected cells...
December 30, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/29289728/associations-of-types-of-pain-with-crack-level-tooth-level-and-patient-level-characteristics-in-posterior-teeth-with-visible-cracks-findings-from-the-national-dental-practice-based-research-network
#15
Thomas J Hilton, Ellen Funkhouser, Jack L Ferracane, Valeria V Gordan, Kevin D Huff, Julie Barna, Rahma Mungia, Timothy Marker, Gregg H Gilbert
OBJECTIVES: The objective of this study was to determine which patient traits, behaviors, external tooth and/or crack characteristics correlate with the types of symptoms that teeth with visible cracks exhibit, namely pain on biting, pain due to cold stimuli, or spontaneous pain. METHODS: Dentists in the National Dental Practice-Based Research Network enrolled a convenience sample of subjects each of whom had a single, vital posterior tooth with at least one observable external crack (cracked teeth); 2,858 cracked teeth from 209 practitioners were enrolled...
December 28, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29288050/enhancement-of-immune-response-and-resistance-against-vibrio-parahaemolyticus-in-kuruma-shrimp-marsupenaeus-japonicus-by-dietary-supplementation-of-%C3%AE-1-4-mannobiose
#16
Gehad E Elshopakey, Engy F Risha, Osama A Abdalla, Yo Okamura, Vu Duc Hanh, Masahisa Ibuki, Raja Sudhakaran, Toshiaki Itami
Supplementation of prebiotic carbohydrates can act as a potent immunomodulator and have the efficacy to induce immune-related genes which are involved in host defense. Pure β-1,4-mannobiose (MNB) showed activation of prophenoloxidase of shrimp hemocytes in vitro. The resistance of kuruma shrimp Marsupenaeus japonicus against Vibrio parahaemolyticus was examined after the shrimp were fed with 0 (control), 0.02, 0.2, and 2% MNB supplemented diets. The results showed significantly higher survival rates in MNB supplemented shrimp than those of the control one from 2 - 12 days post challenge...
December 26, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29286504/features-of-morfological-changes-in-primary-thyroid-gland-ctll-cultures-of-rats-descendants-prenatally-exposed-by-radioisotopes-of-iodine-131
#17
O A Boiko, H Yo Lavrenchuk, A I Lypska, V V Talko, V S Asmolkov
OBJECTIVE: to investigate morphological changes in the primary thyroid cell culture of rat infants whose parents were prenatally exposed by radioisotope iodine 131. MATERIALS AND METHODS: obtaining and culturing of thyroid tissue primary cell cultures of newborn rats, cytological (receipt and analysis of cell cultures agents for optical microscopy), biophysical (flow cytometry), statistics. RESULTS: It was shown that cells in thyroid primary culture of offspring rats prenatally exposed by radioisotopes of iodine 131 signs of destructive degenerative changes were observed mostly when animals of both sexes were irra diated...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29277819/hepatic-resection-followed-by-hepatic-arterial-infusion-chemotherapy-for-hepatocellular-carcinoma-with-intrahepatic-dissemination
#18
Kunitaka Kuramoto, Toru Beppu, Hidetoshi Nitta, Katsunori Imai, Toshiro Masuda, Tatsunori Miyata, Yuki Koga, Yuki Kitano, Takayoshi Kaida, Shigeki Nakagawa, Hirohisa Okabe, Hiromitsu Hayashi, Daisuke Hashimoto, Yo-Ichi Yamashita, Akira Chikamoto, Ken Kikuchi, Hideo Baba
BACKGROUND/AIM: To investigate the utility of adjuvant hepatic arterial infusion chemotherapy (HAIC) following hepatectomy for patients with hepatocellular carcinoma (HCC) with intrahepatic dissemination (IHD) after local ablation therapy. PATIENTS AND METHODS: Twelve patients with HCC with IHD were divided into two groups: HAIC group (n=6) underwent hepatectomy followed by HAIC; and the non-HAIC group (n=6) underwent hepatectomy alone. HAIC with cisplatin and 5-fluorouracil was started within a month and was continued for a month: Results: At the first local ablation, tumors close to the major portal vein and insufficient ablation were recognized in eight (67...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29276855/assessing-differences-in-cardiorespiratory-fitness-with-respect-to-maturity-status-in-highly-trained-youth-soccer-players
#19
Greg Doncaster, John Iga, Viswanath Unnithan
PURPOSE: The purpose of the study was to examine differences in measures of cardiorespiratory fitness and determinants of running economy with respect to maturity status in a group of highly trained youth soccer players. METHODS: A total of 21 highly trained youth soccer players participated in this study. On separate visits, players' peak oxygen uptake (VO2peak), running economy at 3 different speeds [8 km·h-1, 80% gaseous exchange threshold (GET), and 95% GET], and pulmonary oxygen uptake (VO2) kinetics were determined...
December 23, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/29273855/metal-concentrations-in-homing-pigeon-lung-tissue-as-a-biomonitor-of-atmospheric-pollution
#20
Jia Cui, Richard S Halbrook, Shuying Zang, Shuang Han, Xinyu Li
Atmospheric pollution in urban areas is a major worldwide concern with potential adverse impacts on wildlife and humans. Biomonitoring can provide direct evidence of the bioavailability and bioaccumulation of toxic metals in the environment that is not available with mechanical air monitoring. The current study continues our evaluation of the usefulness of homing pigeon lung tissue as a biomonitor of atmospheric pollution. Homing pigeons (1-2, 5-6, and 9-10+ year old (yo)) collected from Guangzhou during 2015 were necropsied and concentrations of cadmium (Cd), lead (Pb), and mercury (Hg) were measured in lung tissue...
December 22, 2017: Ecotoxicology
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