keyword
https://read.qxmd.com/read/38543157/the-effect-of-heparin-and-other-exogenous-glycosaminoglycans-gags-in-reducing-il-1%C3%AE-induced-pro-inflammatory-cytokine-il-8-and-il-6-mrna-expression-and-the-potential-role-for-reducing-inflammation
#1
JOURNAL ARTICLE
Murtaza Jafri, Lin Li, Binhua Liang, Ma Luo
Glycosaminoglycans (GAGs) are long linear polysaccharides found in every mammalian tissue. Previously thought only to be involved in cellular structure or hydration, GAGs are now known to be involved in cell signaling and protein modulation in cellular adhesion, growth, proliferation, and anti-coagulation. In this study, we showed that GAGs have an inhibitory effect on the IL-1β-stimulated mRNA expression of IL-6 and IL-8. Exogenous heparin ( p < 0.0001), heparan ( p < 0.0001), chondroitin ( p < 0...
March 14, 2024: Pharmaceuticals
https://read.qxmd.com/read/38526751/covid-19-vaccination-affects-short-term-anti-coagulation-levels-in-warfarin-treatment
#2
JOURNAL ARTICLE
Li-Hua Liu, Yang-Zhao Zhou, Tian-Yu Li, Da-Bin Kuang, Qun Liang, Lei Chen, Da-Feng Yang, Xia Zhang, Sheng-Lan Tan
Vaccines against SARS-CoV-2 have been recommended across the world, yet no study has investigated whether COVID-19 vaccination influences short-term warfarin anti-coagulation levels. Patients on stable warfarin treatment who received anti-SARS-CoV-2 vaccination were prospectively enrolled and followed up for three months. INR values less than 10 days before vaccination (baseline), 3-5 days (short-term) and 6-14 days (medium-term) after vaccination were recorded as INR0, INR1, and INR2, respectively. The variations of INR values within individuals were compared, and the linear mixed effect model was used to evaluate the variations of INR values at different time points...
March 25, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38525920/double-crosslinking-decellularized-bovine-pericardium-of-dialdehyde-chondroitin-sulfate-and-zwitterionic-copolymer-for-bioprosthetic-heart-valves-with-enhanced-antithrombogenic-anti-inflammatory-and-anti-calcification-properties
#3
JOURNAL ARTICLE
Shubin Shi, Mengyue Hu, Xu Peng, Can Cheng, Shaoxiong Feng, Xinyun Pu, Xixun Yu
Due to the increasing aging population and the advancements in transcatheter aortic valve replacement (TAVR), the use of bioprosthetic heart valves (BHVs) in patients diagnosed with valvular disease has increased substantially. Commercially available glutaraldehyde (GA) cross-linked biological valves suffer from reduced durability due to a combination of factors, including the high cell toxicity of GA, subacute thrombus, inflammation and calcification. In this study, oxidized chondroitin sulfate (OCS), a natural polysaccharide derivative, was used to replace GA to cross-link decellularized bovine pericardium (DBP), carrying out the first crosslinking of DBP to obtain OCS-BP...
March 25, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38513233/paroxysmal-nocturnal-hemoglobinuria-related-thrombosis-in-the-era-of-novel-therapies-a-2043-patient-years-analysis
#4
JOURNAL ARTICLE
Carmelo Gurnari, Hussein Awada, Simona Pagliuca, Danai Dima, Fauzia Ullah, Naomi Kawashima, Yasuo Kubota, Ceylan Colak, Valeria Visconte, Bhumika J Patel, Vikram Dhillon, Naimisha Marneni, Suresh Kumar Balasubramanian, Ashwin Kishtagari, Taha Bat, Jaroslaw P Maciejewski
Thrombophilia is one of the principal features of paroxysmal nocturnal hemoglobinuria (PNH) and constitutes the main cause of disease morbidity/mortality. Anti-complement treatment has revolutionized the natural history of PNH with control of the hemolytic process and abolition of thrombotic events (TE). However, no guidelines exist for the management of thromboembolic complications in this setting, with type and duration of anti-coagulation depending on individual practices. Besides, a scarcity of data is present on the efficacy of direct oral anti-coagulants (DOACs)...
March 21, 2024: Blood
https://read.qxmd.com/read/38508801/tailoring-left-ventricular-assist-device-cannula-implantation-using-coupled-multi-scale-multi-objective-optimization
#5
JOURNAL ARTICLE
Abubakar Dankano, Ray Prather, Blake Lozinski, Eduardo Divo, Alain Kassab, William DeCampli
BACKGROUND: The frequent occurrence of thromboembolic cerebral events continues to limit the widespread implementation of Ventricular Assist Devices (VAD) despite continued advancements in VAD design and anti-coagulation treatments. Recent studies point to the optimal positioning of the outflow graft (OG) as a potential mitigator of post implantation thromboembolism. OBJECTIVE: This study aims to examine the tailoring of the OG implantation orientation with the goal of minimizing the number of thrombi reaching the cerebral vessels by means of a formal shape optimization scheme incorporated into a multi-scale hemodynamics analysis...
March 2024: Medical Engineering & Physics
https://read.qxmd.com/read/38502196/an-up-to-date-review-of-biomedical-applications-of-serratiopeptidase-and-its-biobetter-derivatives-as-a-multi-potential-metalloprotease
#6
REVIEW
Seyedeh Bahareh Hosseini, Masoumeh Azizi, Seyed Ali Nojoumi, Vahideh Valizadeh
Serratiopeptidase is a bacterial metalloprotease used in a variety of medical applications. The multidimensional properties of serratiopeptidase make it noticeable as a miraculous enzyme. Anti-coagulant, anti-inflammatory and anti-biofilm activity of serratiopeptidase making it useful in reducing pain and swelling associated with various conditions including arthritis, diabetes, cancer, swelling, pain and also thrombolytic disorders. It breaks down fibrin, thins the fluids formed during inflammation and due to its anti-biofilm activity, can be used in the combination of antibiotics to reduce development of antibiotic resistance...
March 19, 2024: Archives of Microbiology
https://read.qxmd.com/read/38468017/group-xiv-c-type-lectins-emerging-targets-in-tumor-angiogenesis
#7
REVIEW
Elliott J Yee, Isaac Vigil, Yi Sun, Robert J Torphy, Richard D Schulick, Yuwen Zhu
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of glycoproteins that are implicated in a broad range of physiologic processes. The group XIV subfamily of CTLDs are comprised of CD93, CD248/endosialin, CLEC14a, and thrombomodulin/CD141, and have important roles in creating and maintaining blood vessels, organizing extracellular matrix, and balancing pro- and anti-coagulative processes. As such, dysregulation in the expression and downstream signaling pathways of these proteins often lead to clinically relevant pathology...
March 12, 2024: Angiogenesis
https://read.qxmd.com/read/38462108/a-synergistic-strategy-based-on-active-hydroxymethyl-amine-compounds-and-fucoidan-for-bioprosthetic-heart-valves-with-enhancing-anti-coagulation-and-anti-calcification-properties
#8
JOURNAL ARTICLE
Hongxia Pu, Canyu Wang, Tao Yu, Xiaotong Chen, Gaocan Li, Da Zhu, Xiangbin Pan, Yunbing Wang
With an aging population, the patients with valvular heart disease (VHD) are growing worldwide, and valve replacement is a primary choice for these patients with severe valvular disease. Among them, bioprosthetic heart valves (BHVs), especially BHVs trough transcatheter aortic valve replacement, are widely accepted by patients on account of their good hemodynamics and biocompatibility. Commercial BHVs in clinic are prepared by glutaraldehyde cross-linked pericardial tissue with the risk of calcification and thrombotic complications...
March 8, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38445636/safflower-yellow-for-injection-enhances-anti-coagulation-of-warfarin-in-rats-implications-in-pharmacodynamics-and-pharmacokinetics
#9
JOURNAL ARTICLE
Yan Liu, Jiahui Sun, Chunjuan Yang, Mengnan Qin, Shiwei Xu, Yue Zhao, Gaofeng Liu
This study investigated whether Safflower Yellow for injection (SYI) would affect the anticoagulation of warfarin in rats.Wistar male rats were divided into six groups randomly and administered with SYI (9 mg/kg, intraperitoneal injection) in single-dose and steady-dose warfarin (0.2 mg/kg, oral gavage) respectively. The pharmacodynamic parameters of PT and APTT were measured by a coagulation analyzer. R/S -warfarin concentration was measured by UHPLC-MS/MS, and pharmacokinetic parameters calculated using DAS 2...
March 6, 2024: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://read.qxmd.com/read/38443027/heart-failure-with-low-ejection-fraction-and-in-sinus-rhythm-should-we-anti-coagulate-to-reduce-stroke-burden
#10
JOURNAL ARTICLE
Debabrata Chakraborty
No abstract text is available yet for this article.
January 1, 2024: Neurology India
https://read.qxmd.com/read/38432204/venous-thromboembolism-prophylaxis-in-inflammatory-bowel-disease-inpatients-systematic-review-and-meta-analysis
#11
Rotem McNeil, Danielle Fredman, Ofir Eldar, Anat Gafter-Gvili, Tomer Avni
INTRODUCTION: Inflammatory bowel disease (IBD) patients are three-times more likely to develop venous thromboembolism (VTE), and guidelines recommend prophylaxis during all hospitalizations. In this systematic review we sought to assess for the benefits and risks of VTE prophylaxis in hospitalized IBD patients. METHODS: We performed a systematic review and meta-analysis. We searched MEDLINE and others up to 2/2022, for studies on IBD inpatients treated with prophylactic anti-coagulation during hospitalization, compared to no prophylaxis...
March 1, 2024: Acta Haematologica
https://read.qxmd.com/read/38415957/the-effect-of-the-anti-coagulant-edta-on-the-deposition-and-adhesion-of-whole-blood-deposits-on-non-porous-substrates
#12
JOURNAL ARTICLE
Deborah A Hughes, Roland A H van Oorschot, Bianca Szkuta, Xavier A Conlan
An investigation into whether the addition of a commonly used anti-coagulant agent like ethylenediaminetetraacetic acid (EDTA) has an impact on the adhesion potential of blood to non-porous substrates was conducted. Two non-porous substrates (aluminum and polypropylene) exhibiting six different surface roughness categories (R1-R6) were used as test substrates upon which either whole blood or blood treated with EDTA was deposited. Samples were exposed to different drying periods (24 hours, 48 hours, and 1 week) before undergoing a tapping agitation experiment in order to evaluate the adhesion to the surface...
February 28, 2024: Journal of Forensic Sciences
https://read.qxmd.com/read/38414796/a-strategy-for-mechanically-integrating-robust-hydrogel-tissue-hybrid-to-promote-the-anti-calcification-and-endothelialization-of-bioprosthetic-heart-valve
#13
JOURNAL ARTICLE
Haoshuang Wu, Nuoya Chen, Tiantian Zheng, Li Li, Mengyue Hu, Yumei Qin, Gaoyang Guo, Li Yang, Yunbing Wang
Bioprosthetic heart valve (BHV) replacement has been the predominant treatment for severe heart valve diseases over decades. Most clinically available BHVs are crosslinked by glutaraldehyde (GLUT), while the high toxicity of residual GLUT could initiate calcification, severe thrombosis, and delayed endothelialization. Here, we construed a mechanically integrating robust hydrogel-tissue hybrid to improve the performance of BHVs. In particular, recombinant humanized collagen type III (rhCOLIII), which was precisely customized with anti-coagulant and pro-endothelialization bioactivity, was first incorporated into the polyvinyl alcohol (PVA)-based hydrogel via hydrogen bond interactions...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38403560/effects-of-blood-sample-storage-time-temperature-anti-coagulants-and-blood-stabiliser-on-lymphocyte-phenotyping
#14
JOURNAL ARTICLE
Yunyu Lao, Alex Quach, Khalida Perveen, Charles Hii, Antonio Ferrante
Medical diagnostic laboratories have come under further scrutiny to ensure quality standards of their service and external quality assurance (EQA) programs involving multiple laboratories have been used to gauge this quality based on a consensus. However, because of the geographical distances within a country or internationally, cell surface marker expressions may change due to time delays and transport temperatures. Attention was given to this issue some decades ago and hence requires a re-evaluation in consideration of updated methods, reagents and instruments for flow cytometry and phenotyping...
February 7, 2024: Pathology
https://read.qxmd.com/read/38394931/effect-of-extraction-method-on-the-structure-and-bioactivity-of-polysaccharides-from-activated-sludge
#15
JOURNAL ARTICLE
Jie Liu, Zi Zhang, Yangfan Deng, Guanghao Chen
Resource recovery is a pivotal facet of waste activated sludge treatment, particularly within the framework of carbon neutrality and the circular economy. Polysaccharides are emerging as a valuable resource from waste activated sludge, and the choice of extraction method affects the properties of the polysaccharides, which is of utmost importance for subsequent application. This investigation examined the effects of six extraction methods (i.e., acidic, alkaline, ultrasonication, hot-water, microwave, and electric treatments) on the yield, chemical composition, structural characteristics, and bioactivities of polysaccharides extracted from sludge...
January 24, 2024: Water Research
https://read.qxmd.com/read/38393674/therapeutic-implication-of-microrna-320a-antagonist-in-attenuating-blood-clots-formed-during-venous-thrombosis
#16
JOURNAL ARTICLE
Swati Srivastava, Iti Garg, Nilanjana Ghosh, Rajeev Varshney
Venous thrombosis (VT) is a complex multi-factorial disease and a major health concern worldwide. Its clinical implications include deep vein thrombosis (DVT) and pulmonary embolism (PE). VT pathogenesis involves intricate interplay of various coagulants and anti-coagulants. Growing evidences from epidemiological studies have shown that many non-coding microRNAs play significant regulatory role in VT pathogenesis by modulating expressions of large number of gene involved in blood coagulation. Present study aimed to investigate the effect of human micro RNA (hsa-miR)-320a antagonist on thrombus formation in VT...
February 23, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38382586/the-angiogenesis-modulating-effects-of-coumarin-derivatives
#17
JOURNAL ARTICLE
Han-Ting Huang, Ching-Yuan Huang, Chih-Jou Lee, Bo-Jie Sun, Zong-Wei Jhang, Chi-Chung Wen, Yun-Hsin Wang, Tao-Sheng Li, Ching-Yuh Chern, Yau-Hung Chen
Coumarin is a natural compound that is rich in plants. Coumarin and its derivates were reported to have many biological activities, such as anti-bacterial, anti-tumor, and anti-coagulation. In this study, we examined the angiogenic modulating activities of six previously synthesized coumarin derivatives (Compound #1-#6) in zebrafish embryos and further confirmed them in a chick model. According to the survival rate in a zebrafish model, Compound #1 (100 %), #2 (82.5-100 %), and #4 (100 %) showed much less toxicity than Compound #3 (19...
February 19, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://read.qxmd.com/read/38361870/a-case-of-rectus-sheath-hematoma-in-the-setting-of-paroxysmal-coughing-and-platelet-dysfunction
#18
Erika Harris, Taylor Fleshman, Adam Franks
Rectus sheath hematoma (RSH) is an uncommon cause of acute abdominal pain that may mimic other intra-abdominal pathologies. It is caused by the rupture of the superior or inferior epigastric artery or vein in the rectus abdominis muscle. Clinical features include sudden-onset abdominal pain and a palpable mass, and common risk factors include anti-coagulants, platelet dysfunction, and cough. Workup includes a physical exam, complete blood count, coagulation profile, ultrasound, and computed tomography. While most cases are treated conservatively, uncontrolled hemorrhage may be lethal and requires prompt recognition...
December 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38358199/red-blood-cell-indices-in-different-hemoglobinopathies-a-cross-sectional-study-in-eastern-india
#19
JOURNAL ARTICLE
Ayandip Nandi, Manas Talukdar, Saikat Bhattacharya, Susruta Sen, Supratik Biswas, Kuntal Roy
INTRODUCTION: Beta thalassemia and hemoglobin (HbE)-related hemoglobinopathies are common public health problems in developing countries. High-performance liquid chromatography (HPLC) is currently the diagnostic test of choice for carrier detection, but it is costly. Hence, some initial screening and complementary tests are required, which can be affordable. AIMS: To find out the distribution of different red blood cell (RBC) indices in beta thalassemia trait (BTT) and HbE-related hemoglobinopathies and to determine their significance as screening tests to distinguish between these hemoglobinopathies...
2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38358195/shaggy-aorta-an-autopsy-analysis
#20
JOURNAL ARTICLE
Pranita Zare, Pradeep Vaideeswar
AIMS: Shaggy aorta is defined as "very extensive atheromatous disease with diffuse ulcers associated with soft, loosely held debris and a paucity of actual thrombus" and often results in visceral or peripheral arterial embolization (shaggy aorta syndrome). Most of the studies are clinico-radiological with hardly any assessment of the pathological features. We present an autopsy analysis of shaggy aorta. MATERIALS AND METHODS: A retrospective study of autopsied cases of shaggy aorta over 15 years was conducted...
2024: Indian Journal of Pathology & Microbiology
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