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https://www.readbyqxmd.com/read/29655810/a-review-of-interventions-to-increase-vena-cava-filter-retrieval-rates
#1
REVIEW
Amie Goodin, Qiong Han, Driss Raissi, Joshua D Brown
OBJECTIVE: Inferior vena cava filters (IVCFs) are indicated for therapeutic and prophylactic treatment of venous thromboembolism in patients where anti-coagulation has failed or is contraindicated. Retrievable IVCFs are not always retrieved despite clinical recommendations. The purpose of this review is to compare results in the literature regarding interventions to improve IVCF retrieval rates. METHODS: Articles were identified via the search terms "vena cava filters" and "inferior vena cava filters" in conjunction with "retrieval...
April 12, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29655662/evaluation-of-low-intensity-anti-coagulation-with-a-fully-magnetically-levitated-centrifugal-flow-circulatory-pump-the-magentum-1-study
#2
Ivan Netuka, Peter Ivák, Zuzana Tučanová, Stanislav Gregor, Ondrej Szárszoi, Poornima Sood, Daniel Crandall, Jessica Rimsans, Jean Marie Connors, Mandeep R Mehra
BACKGROUND: The HeartMate 3 left ventricular assist system is engineered to avoid pump thrombosis, yet bleeding complications persist. We investigated the safety of low-intensity anti-coagulation in patients with the HeartMate 3. METHODS: The Minimal AnticoaGulation EvaluatioNTo aUgment heMocompatibility (MAGENTUM 1) pilot study is a prospective, single-arm study of low-intensity warfarin anti-coagulation in patients implanted with the HeartMate 3 pump. After standard warfarin anti-coagulation (international normalized ratio [INR] 2...
March 27, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29650295/acquired-von-willebrand-syndrome-and-impaired-platelet-function-during-venovenous-extracorporeal-membrane-oxygenation-rapid-onset-and-fast-recovery
#3
Johannes Kalbhenn, Axel Schlagenhauf, Simone Rosenfelder, Axel Schmutz, Barbara Zieger
BACKGROUND: Bleeding contributes to the high mortality of venovenous extracorporeal membrane oxygenation (vvECMO). The development of acquired von Willebrand syndrome (AVWS) has been identified as relevant pathology during ECMO. This study was performed to determine the onset of AVWS after implantation and the recovery of von Willebrand factor (VWF) parameters after explantation of ECMO in a large cohort of patients. METHODS: VWF parameters of 59 patients treated with vvECMO at a university ECMO center were obtained before ECMO implantation, during therapy, and after explantation...
March 17, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29644269/blunt-traumatic-celiac-artery-avulsion-managed-with-celiac-artery-ligation-and-open-aorto-celiac-bypass
#4
Matthew D Kronick, Andrew R Doben, Marvin E Morris, Ronald I Gross, Amanda Kravetz, Jeffry T Nahmias
Traumatic celiac artery injuries are rare and highly lethal with reported mortality rates of 38-62%. The vast majority are caused by penetrating trauma with only 11 reported cases due to blunt trauma (Graham et al., 1978; Asensio et al., 2000, 2002). Only 3 of these cases were complete celiac artery avulsions. Management options described depend upon the type of injury and have included medical therapy with anti-platelet agents or anti-coagulants, endovascular stenting, and open ligation. We report a case of a survivor of complete celiac artery avulsion from blunt trauma managed by open bypass...
October 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29622455/-how-long-will-i-continue-to-be-normal-adults-with-a-fontan-circulation-s-greatest-concerns
#5
Karin du Plessis, Rebecca Peters, Ingrid King, Kirsty Robertson, Jonathan Mackley, Rachel Maree, Tracy Stanley, Louise Pickford, Brian Rose, Matthew Orchard, Helen Stewart, Yves d'Udekem
BACKGROUND: Little is known about adults living with a Fontan circulation's concerns outside the scope of their clinical outcomes. We examined adults with a Fontan circulations' greatest concerns, as well as their concerns around anti-coagulation, pregnancy and finances. METHODS: Adults with a Fontan circulation in the Australian and New Zealand Fontan Registry were invited to complete an anonymous online survey, of which 57 participated. A qualitative method approach using thematic analyses was used...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29608549/budding-uninhibited-by-benzimidazole-1-insufficiency-prevents-acute-renal-failure-in-severe-sepsis-by-maintaining-anti-coagulant-functions-of-vascular-endothelial-cells
#6
Yutaka Matsubara, Takuya Matsumoto, Keiji Yoshiya, Ayae Yoshida, Seiichi Ikeda, Tadashi Furuyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Masatoshi Nomura, Yoshihiko Maehara
Severe sepsis is critical to health and can result in acute renal failure (ARF). Tissue factor (TF) and thrombomodulin (TM) play key roles in vascular endothelial functions by helping maintain microcirculation in the kidney. Budding uninhibited by benzimidazole-1 (Bub1) plays a role in Akt and JNK signaling, which control TF and TM, respectively. We hypothesized that Bub1 could control vascular endothelial function in sepsis. The aim of this study was to determine the role of Bub1 in septic ARF. We used Mouse cecum ligation and puncture (CLP) using low Bub1 expressing (Bub1) and wild-type (Bub1) mice in vivo and lipopolysaccharide (LPS) stimulation of human aortic endothelial cell (HAEC) in vitro...
March 30, 2018: Shock
https://www.readbyqxmd.com/read/29606406/management-of-spontaneous-soft-tissue-hemorrhage-secondary-to-anticoagulant-therapy-a-cohort-study
#7
Vincenzo G Menditto, Francesca Fulgenzi, Sirio Lombardi, Anna Dimitriadou, Cinzia Mincarelli, Marzia Rosati, Roberto Candelari, Giovanni Pomponio, Aldo Salvi, Armando Gabrielli
STUDY OBJECTIVE: The optimal management of patients receiving heparin, warfarin or direct anti-coagulant therapy who experience spontaneous, severe, life-threatening soft-tissue hemorrhage (SSTH) is unclear. The purpose of this study is to investigate efficacy and safety of the interventional protocol implemented in our department. METHODS: In this retrospective cohort study, we analyzed data from 80 consecutive patients with SSTH secondary to anticoagulation therapy diagnosed by the appropriate computed tomography scan...
March 23, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29604561/effect-of-phospholipid-coating-on-the-migration-of-plasticizers-from-pvc-tubes
#8
Frank Münch, Christine Höllerer, André Klapproth, Elisabeth Eckert, André Rüffer, Robert Cesnjevar, Thomas Göen
Plasticizers in polyvinyl chloride (PVC) are not covalently bound to the polymer and can thus migrate into the contact medium. The presented study investigated the potential effects of phospholipid-lining as anti-coagulation coating (ACC) on the migration rate of plasticizers from PVC tubing into blood. For the in-vitro study, five different groups of tubing sets in six replicates were perfused with sheep blood (Group A: PVC plasticized with di-(2-ethylhexyl) phthalate (DEHP) without ACC, Group B: DEHP-plasticized PVC with ACC, Group C: PVC plasticized with tri-(2-ethylhexyl) trimellitate (TOTM) without ACC, Group D: TOTM-plasticized PVC with ACC, Group E (control group): polyolefin material with ACC but without plasticizers)...
March 20, 2018: Chemosphere
https://www.readbyqxmd.com/read/29599304/aspirin-in-the-management-of-patients-with-prostate-cancer-undergoing-radiotherapy-friend-or-foe
#9
REVIEW
Bianca Mascan, Laure Marignol
Aspirin has cyclooxygenase-2 (COX2)-mediated anti-inflammatory and anti-coagulant properties that may confer a positive effect in preventing and limiting the progression of prostate cancer. Prostate cancer has been shown to have poor treatment outcomes due to therapeutic resistance; therefore, COX2 inhibition caused by aspirin could represent an opportunity to augment current therapies. This is particularly of interest to patients undergoing radiation therapy (RT) where inflammation is a common side-effect...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29597155/dynamic-wetting-of-human-blood-and-plasma-on-various-surfaces
#10
Athanasios Milionis, K Ghokulla Krishnan, Eric Loth, Michael Lawrence
Surface fouling from coagulated blood is a major challenge in medical industry. However, the wetting physics and dynamics of blood on surfaces are not well understood nor are the quantitative influences due to surface and fluid properties. The present study investigates the effect of surface wetting and dynamics resulting for human blood and plasma, namely hemophobicity, on surfaces with different wettability. To examine effects of fluid properties, the wetting characteristics for liquids with Ohnesorge number similar to that of blood and plasma are also considered...
March 20, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29583037/detection-of-atrial-fibrillation-during-pulpal-blood-flow-assessment-using-doppler-ultrasound-a-case-report
#11
Chan-Hyun Lee, Euiseong Kim, Dohyun Kim
This report describes the case of a 52-year-old male patient who exhibited suspicious pulsation patterns during pulpal blood flow assessment using Doppler ultrasound. Initially, he was not aware of his cardiovascular problem; however, after referral to a medical clinic, he was diagnosed with atrial fibrillation. The patient was injured in a motor vehicle accident and referred to our clinic for management of multiple traumatized teeth. On clinical examination, several teeth exhibited negative responses to cold and electrical sensibility tests...
March 27, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29579617/benefits-of-left-ventricular-endocardial-pacing-comparing-failed-implants-and-prior-non-responders-to-conventional-cardiac-resynchronization-therapy-a-subanalysis-from-the-alsync-study
#12
Mauro Biffi, Pascal Defaye, Pierre Jaïs, Franco Ruffa, Christophe Leclercq, Daniel Gras, Zhongping Yang, Bart Gerritse, Matteo Ziacchi, John M Morgan
OBJECTIVE: Cardiac resynchronisation therapy (CRT) is limited by a substantial proportion of non-responders. Left ventricular endocardial pacing (LVEP) may offer enhanced possibility to deliver CRT in patients with a failed attempt at implantation and to improve clinical status of CRT non-responders. METHODS: The ALternate Site Cardiac ResYNChronisation (ALSYNC) study was a prospective, multi-centre cohort study that included 118 CRT patients with a successfully implanted endocardial left ventricular (LV) lead, including 90 failed coronary sinus (CS) implants and 28 prior non-responders who had worsened or unchanged heart failure status after at least 6 months of optimal conventional CRT therapy...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29579357/venous-thromboembolic-events-in-idiopathic-inflammatory-myopathy-occurrence-and-relation-to-disease-onset
#13
Aleksandra Antovic, Antonella Notarnicola, John Svensson, Ingrid E Lundberg, Marie Holmqvist
OBJECTIVES: To assess the incidence of venous thromboembolism (VTE) in patients with idiopathic inflammatory myopathies (IIM), and compare the incidence in IIM to the incidence in the general population. To identify patient categories at high risk and investigate the development of risk in relation to IIM diagnosis. METHODS: Using nationwide registers we identified a cohort of 440 individuals with newly diagnosed IIM and 4459 individuals from the general population...
March 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29573721/novel-heparin-mimetics-reveal-cooperativity-between-exosite-2-and-sodium-binding-site-of-thrombin
#14
May H Abdel Aziz, Umesh R Desai
INTRODUCTION: Thrombin is a primary target of most anticoagulants. Yet, thrombin's dual and opposing role in pro- as well as anti- coagulant processes imposes considerable challenges in discovering finely tuned regulators that maintain homeostasis, rather than disproportionately changing the equilibrium to one side. In this connection, we have been studying exosite 2-mediated allosteric modulation of thrombin activity using synthetic agents called low molecular weight lignins (LMWLs)...
March 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29564352/management-of-sequelae-of-kawasaki-disease-in-adults
#15
REVIEW
John B Gordon, Jane C Burns
Background: A growing population of young adults is presenting to cardiologists with late manifestations of Kawasaki disease (KD) that include cardiomyopathy, ischemia, and infarction. The management of these conditions differs in important ways from atherosclerotic heart disease, and yet there is little awareness in the adult cardiology community regarding the special challenges posed by the cardiovascular sequelae of KD. Methods: Observations were made on a population of 140 adult KD patients enrolled in the San Diego Adult KD Collaborative Study...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29559690/estimated-glomerular-filtration-ratio-is-a-better-index-than-creatinine-clearance-cockcroft-gault-for-predicting-the-prevalence-of-atrial-fibrillation-in-the-general-japanese-population
#16
Yutaka Yonezawa, Shigeo Horinaka, Chiaki Shirakawa, Yoshio Kogure
Direct oral anti-coagulants (DOACs) have been used in patients with non-valvular atrial fibrillation (AF), and renal function evaluation using the CCr (Cockcroft-Gault) is recommended as a criterion for the reduction of DOAC. In contrast, estimated glomerular filtration rate (eGFR) is usually used as an index of renal function in daily practice. We determined the age- and gender-specific prevalence rates of AF and whether CCr or eGFR was associated with the prevalence of AF. Data from the periodic health examinations of 108,951 subjects were collected...
March 20, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29555505/haemostatic-agent-etamsylate-in-vitro-and-in-vivo-antagonizes-anti-coagulant-activity-of-heparin
#17
M Yolanda Cobo-Nuñez, Mariam El Assar, Pedro Cuevas, Alberto Sánchez-Ferrer, Jennifer Martínez-González, Leocadio Rodríguez-Mañas, Javier Angulo
Etamsylate is indicated for several anti-hemorrhagic indications in human and veterinary medicine. However, etamsylate has been shown to be effective only in specific haemorrhagic situations. Furthermore, mechanism of action of etamsylate is not known but recent research has shown its ability to inhibit heparin binding to several growth factors. We have evaluated the ability of etamsylate to interfere with the activities of heparin. Effects of etamsylate on vasodilatory activity of heparin were evaluated in rat aortic segments...
March 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29549559/no-effectiveness-of-anticoagulants-for-thromboprophylaxis-after-non-major-knee-arthroscopy-a-systemic-review-and-meta-analysis-of-randomized-controlled-trials
#18
REVIEW
Gang Zheng, Qian Tang, Ping Shang, Xiao-Yun Pan, Hai-Xiao Liu
Arthroscopic knee surgery is the most commonly performed orthopedic procedure worldwide and whether thromboprophylaxis should be undertaken after knee arthroscopy is still controversial. To evaluate the efficacy of thromboprophylaxis for deep venous thrombosis (DVT) and venous thromboembolism (VTE) after knee arthroscopic surgery. A meta-analysis was conducted using data from eight randomized trials (4148 patients) to compare thromboprophylaxis with placebo or no prophylactic treatment in patients undergoing knee arthroscopy...
March 16, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29544531/head-injury-on-warfarin-likelihood-of-delayed-intracranial-bleeding-in-patients-with-negative-initial-head-ct
#19
Amer Afaneh, Jennifer Ford, Jenna Gharzeddine, Alexandre Mazar, R David Hayward, Joseph Buck
OBJECTIVE: To determine the likelihood that head injured patients on Warfarin with a negative initial head CT will have a positive repeat head CT. A retrospective chart review of our institution's trauma registry was performed for all patients admitted for blunt head trauma and on Warfarin anti-coagulation from January 2009 to April 2014. Inclusion criteria included patients over 18 years of age with initial GCS ≥ 13, INR greater than 1.5 and negative initial head CT. Initial CT findings, repeat CT findings and INR were recorded...
March 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29542410/dabco-catalyzed-green-and-efficient-synthesis-of-2-amino-4h-pyrans-and-their-biological-evaluation-as-antimicrobial-and-anticancer-agents
#20
Amit Shivajirao Waghmare, Shivaji Sandu Pandit, Dayanand M Suryawanshi
AIM AND OBJECTIVE: 4H-pyran is one of the most well-known groups of synthetic heterocyclic compounds and it has attracted considerable attention of chemists in recent years because of their extensive range of biological and pharmaceutical activities. These compounds are used as antibacterial, anticancer agents, anti-coagulants, spasmolytics and anti-anaphylactic. 4H-pyran derivatives are utilized in cosmetics, pigments, biodegradable agrochemicals as well as photoactive materials. In addition, 4H-pyrans are also helpful as cognitive enhancers for the treatment of neuro degenerative diseases, including Alzheimer's disease, as well as for the treatment of schizophrenia and myoclonus...
March 14, 2018: Combinatorial Chemistry & High Throughput Screening
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