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https://www.readbyqxmd.com/read/29447772/the-optimal-anti-coagulation-for-enhanced-risk-patients-post-catheter-ablation-for-atrial-fibrillation-ocean-trial
#1
Atul Verma, Andrew C T Ha, Paulus Kirchhof, Gerhard Hindricks, Jeff S Healey, Michael D Hill, Mukul Sharma, D George Wyse, Jean Champagne, Vidal Essebag, George Wells, Dhiraj Gupta, Hein Heidbuchel, Prashanthan Sanders, David H Birnie
BACKGROUND: The optimal long-term antithrombotic regimen for patients after successful catheter-based atrial fibrillation (AF) ablation is not well defined. Presently, practice variation exists, and the benefits of oral anticoagulation over antiplatelet therapy across the entire spectrum of stroke risk profile remain undefined in the postablation population. To date, there are no randomized trials to inform clinicians on this therapeutic question. OBJECTIVE: The objective was to assess whether rivaroxaban is superior to acetylsalicylic acid (ASA) in reducing the risk of clinically overt stroke, systemic embolism, or covert stroke among patients without apparent recurrent atrial arrhythmias for at least 1 year after their most recent AF ablation procedure...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29445077/successful-external-cardioversion-via-fluoroscopic-electrode-positioning-in-patients-with-enlarged-trans-thoracic-diameter
#2
Koroush Khalighi, Amirsina Talebian, Rubinder Singh Toor, Seyed Abbas Mirabbasi
BACKGROUND Atrial fibrillation is the most common cardiac arrhythmia. It increases the risk of stroke by at least five-fold and is associated with higher risk for mortality and morbidity. Therefore, prompt diagnosis and treatment is crucial. In addition to anti-coagulation therapy, electrical and pharmacological cardioversion to restore sinus rhythm remains the standard of care. The most common and effective method for electrical cardioversion is achieved with placement of electrodes in the anteroposterior position...
February 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29444597/an-experimental-model-for-hypertensive-crises-emergencies-long-term-high-fat-diet-followed-by-acute-vasoconstriction-stress-on-spontaneously-hypertensive-rats
#3
Hong Liu, Wei-Wei Su, Chao-Feng Long, Wei-Jian Zhang, Pei-Bo Li, Zhong Wu, Yin-Yin Liao, Xuan Zeng, Tao-Bin Chen, Yu-Ying Zheng, Zeng-Hao Yan, Cong Bi, Hong-Liang Yao
Currently, the prevention and treatment of hypertensive crises especially when it occurs with serious adverse outcomes have led to worldwide controversy. Despite of clinical possibilities of multiple agents, clinical failures still occur frequently. Therefore, early evaluations and observations of different therapies on appropriate animals should be emphasized. In the present study, an animal model for hypertensive crises emergencies was firstly established and experimentally testified. Five-month-male spontaneously hypertensive rat was consecutively fed with 60%-Kcal fat diet for four, six, and eight weeks with body weight and blood pressure monitored every two weeks, and then followed by an acute vasoconstriction stress of 5-min ice-bath treatment in the 4-h time interval of two adrenaline injections (0...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29436624/clinical-verification-of-lou-type-warfarin-pharmacokinetic-dosing-algorithms-equation
#4
Jiangang Jiang, Ningning Ji, Jingliang Lan, Xiaoping Ge, Xiaoma Du
Warfarin is the most commonly used oral anti-coagulant in clinic practice. However, it is difficult to recommend the correct dosage due to its narrow therapeutic window. The aim of the present study was to verify the clinical value of the Lou type equation, using pharmacogenetics‑based warfarin dosing algorithms to appropriately predict the actual maintenance dose. A total of 87 Chinese Han patients who required treatment with warfarin were enrolled and randomly divided into the experimental and control groups...
February 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29434126/a-case-of-heart-failure-with-hyperthyroidism-demonstrating-discrepancy-between-the-clinical-course-and-b-type-natriuretic-peptide-levels
#5
Chiaki Kishida, Ryo Naito, Hiroki Kasuya, Tomohiro Kaneko, Kosuke Yabe, Midori Kakihara, Ryosuke Shimai, Hiroyuki Isogai, Dai Ozaki, Yuki Yasuda, Fuminori Odagiri, Tetsuro Miyazaki, Ken Yokoyama, Takashi Tokano, Hajime Koyano, Yuji Nakazato
A 35-year-old Japanese man was emergently admitted to our hospital with chief complaints of palpitation and dyspnea. He has been treated for Basedow's disease. He was diagnosed with acute decompensated heart failure, atrial fibrillation and thyrotoxicosis. We started anti-thyroid agents and a treatment for heart failure with beta blockers and diuretics under anti-coagulation therapy. His B-type natriuretic peptide levels remained high, although the heart failure had been compensated and the heart rate was well controlled while hyperthyroidism still existed...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432822/macromolecular-prodrugs-of-ribavirin-polymer-backbone-defines-blood-safety-drug-release-and-efficacy-of-anti-inflammatory-effects
#6
Kaja Zuwala, Camilla F Riber, Kaja Borup Løvschall, Anna H F Andersen, Lise Sørensen, Paulina Gajda, Martin Tolstrup, Alexander N Zelikin
Macromolecular (pro)drugs hold much promise as broad-spectrum antiviral agents as either microbicides or carriers for intracellular delivery of antiviral drugs. Intriguing opportunity exists in combining the two modes of antiviral activity in the same polymer structure such that the same polymer acts as a microbicide and also serves to deliver the conjugated drug (ribavirin) into the cells. We explore this opportunity in detail and focus on the polymer backbone as a decisive constituent of such formulations...
February 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29407622/simple-method-for-removing-doacs-from-plasma-samples
#7
T Exner, N Michalopoulos, J Pearce, R Xavier, M Ahuja
AIM: To evaluate a simple method using an adsorbent product (DOAC Stop) for extracting direct oral anti-coagulants (DOACs) from plasmas. METHOD: DOAC Stop was tested on normal and a range of abnormal plasmas initially using activated partial thromboplastin time (APTT) tests and a more DOAC-sensitive Russells viper venom-based clotting test (DOAC Test). Further tests for prothrombin time/International Normalized Ratio (PT/INR), lupus anticoagulants, activated protein C (APC) resistance, antithrombin, plasminogen, protein C and S were carried out on various patient samples...
January 30, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29406998/prophylactic-use-of-colchicine-in-preventing-radiation-induced-coronary-artery-disease
#8
T O'Herron, J Lafferty
Radiation therapy is one of the primary treatments in fighting breast cancer, one of the most common cancers in the US. One of the dose limiting factors of this therapy is radiation induced heart damage that results from mediastinal radiation. Recently statins, a medication typically used to lower cholesterol levels, have been suggested as a prophylactic treatment to potentially mitigate this process. Similarly, we hypothesized whether colchicine, an anti-inflammatory medication that is presently used in the treatment of gout and pericarditis, might be used to prevent coronary artery disease induced by radiation therapy...
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29404874/direct-oral-anti-coagulants-compared-to-vitamin-k-antagonists-in-cardioversion-of-atrial-fibrillation-an-updated-meta-analysis
#9
REVIEW
Natale Daniele Brunetti, Nicola Tarantino, Luisa De Gennaro, Michele Correale, Francesco Santoro, Matteo Di Biase
Pharmacological or electrical cardioversion allows immediate symptoms improvement in the setting of paroxysmal or persistent atrial fibrillation (AF), although the periprocedural risk of systemic embolism should be considered. Recently, there was a great interest on the safety and efficacy of direct oral anticoagulants (DOACs) when used for the cardioversion of non-valvular AF. We performed a random-effects meta-analysis of patients undergoing both electrical and pharmacologic cardioversion for non-valvular AF in the RE-LY, ROCKET-AF, ARISTOTLE, ENGAGE AF-TIMI 48, X-VeRT, ENSURE-AF, and EMANATE trials...
February 5, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29399531/deep-vein-thrombosis-pathogenesis-diagnosis-and-medical-management
#10
REVIEW
Jonathan Stone, Patrick Hangge, Hassan Albadawi, Alex Wallace, Fadi Shamoun, M Grace Knuttien, Sailendra Naidu, Rahmi Oklu
Deep vein thrombosis (DVT) is a major preventable cause of morbidity and mortality worldwide. Venous thromboembolism (VTE), which includes DVT and pulmonary embolism (PE), affects an estimated 1 per 1,000 people and contributes to 60,000-100,000 deaths annually. Normal blood physiology hinges on a delicate balance between pro- and anti-coagulant factors. Virchow's Triad distills the multitude of risk factors for DVT into three basic elements favoring thrombus formation: venous stasis, vascular injury, and hypercoagulability...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29387316/anti-coagulation-therapy-following-coronary-endarterectomy-in-patient-with-coronary-artery-bypass-graft
#11
Hamdi Reza Vafaey, Mohammad Taghi Salehi Omran, Sadaf Abbaspour, Nadia Banihashem, Ghassem Faghanzadeh Ganji
Background: Since there is a lack of research on postoperative anticoagulation protocol in patients undergoing coronary artery bypass graft (CABG) / coronary endarterectomy (CE), we recommend a new protocol for anticoagulation in these patients. Methods: In this double-blind randomized clinical trial study, 52 patients undergoing CABG / CE entered the study and were divided into two groups. In group 1, the patients were given warfarin(international normalized ratio (INR) between 2-3) together with 80 mg aspirin daily for 3 months...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29386864/betrixaban-bevyxxa-a-direct-acting-oral-anticoagulant-factor-xa-inhibitor
#12
Jessica W Skelley, Angela R Thomason, Jeffery C Nolen, PharmD Candidate
Betrixaban (Bevyxxa): a direct-acting oral anti-coagulant factor Xa inhibitor.
February 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29383514/closure-of-patent-foramen-ovale-for-cryptogenic-stroke-patients-an-updated-systematic-review-and-meta-analysis-of-randomized-trials
#13
REVIEW
Xuan Niu, Guang Ou-Yang, Peng-Fei Yan, Shu-Lan Huang, Zhen-Tao Zhang, Zhao-Hui Zhang
OBJECTIVE: This systematic review and meta-analysis was performed to investigate the efficacy and safety of transcatheter device closure (TDC) plus anti-thrombotic drugs over medical management alone for patients with cryptogenic stroke and patent foramen oval. METHODS: PubMed, Embase and Cochrane Library database were searched for randomized controlled clinical trials (RCTs). The primary endpoint is the composite of stroke and transient ischemic attack. The secondary endpoints are all-cause mortality, total serious adverse events, atrial fibrillation and bleeding...
January 30, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29371984/clinical-significances-and-features-of-prompt-brain-ct-scan-after-intracranial-artery-stenting-analysis-of-501-cases
#14
Jie Li, Sai-Yu Cheng, Xiao-Yi Xiong, Chun-Mei Duan, Liang Liu, Yu Zhou, Jian-Rong Zhang, Li Wang, Kai Zhou, Zi-Li Gong, Yong Liu, Fei Wei, Jie Shuai, Lin Shen, Qing-Wu Yang
Cerebral hemorrhage is a serious complication of intracranial artery stenting that could be fatal without timely identification and treatment. Prompt brain CT scan would help to evaluate whether cerebral hemorrhage occurs, however, the diverse features of the CT scan immediately after stenting could influence the judgement sometimes. Therefore, we analyzed and summarized these features to help to determine the clinical significance of these CT features. The prompt CT features after stenting were classified into three types...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29370816/prevalence-of-lower-limb-deep-venous-thrombosis-among-adult-hiv-positive-patients-attending-an-outpatient-clinic-at-mulago-hospital
#15
Sosthene Tsongo Vululi, Samuel Bugeza, Muyinda Zeridah, Henry Ddungu, Akello Betty Openy, Mubiru Frank, Rosalind Parkes-Ratanshi
BACKGROUND: Deep venous thrombosis (DVT) and its major complication pulmonary embolism (PE) are collectively known as venous thromboembolism. In Uganda, the prevalence of DVT among HIV patients has not been previously published. The aim of the study was to determine the prevalence and sonographic features of lower limb deep venous thrombosis among HIV positive patients on anti-retroviral treatment (ART). METHODS: This was a cross sectional study in which HIV positive patients on ART were recruited from an out-patient HIV clinic at Mulago National Referral Hospital...
January 25, 2018: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29358327/low-level-overexpression-of-p53-promotes-warfarin-induced-calcification-of-porcine-aortic-valve-interstitial-cells-by-activating-slug-gene-transcription
#16
Li Gao, Yue Ji, Yan Lu, Ming Qiu, Yejiao Shen, Yaqing Wang, Xiangqing Kong, Yongfeng Shao, Yanhui Sheng, Wei Sun
The most frequently used oral anti-coagulant warfarin has been implicated in inducing calcification of aortic valve interstitial cells (AVICs), while the mechanism is not fully understood. The low-level activation of p53 is found to be involved in osteogenic trans-differentiation and calcification of AVICs. Whether p53 participating in warfarin-induced AVIC calcification remains unknown. In this study, we investigated the role of low-level p53 overexpression in warfarin-induced porcine AVIC (pAVIC) calcification...
January 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29352150/identification-and-quantification-of-plasma-calciprotein-particles-with-distinct-physical-properties-in-patients-with-chronic-kidney-disease
#17
Yutaka Miura, Yoshitaka Iwazu, Kazuhiro Shiizaki, Tetsu Akimoto, Kazuhiko Kotani, Masahiko Kurabayashi, Hiroshi Kurosu, Makoto Kuro-O
Calciprotein particles (CPP) are solid-phase calcium-phosphate bound to serum protein fetuin-A and dispersed as colloids in the blood. Recent clinical studies indicated that serum CPP levels were increased with decline of renal function and associated with inflammation and vascular calcification. However, CPP assays used in these studies measured only a part of CPP over a certain particle size and density. Here we show that such CPP are mostly artifacts generated during processing of serum samples in vitro...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337125/facilitating-hemostasis-after-proximal-aortic-surgery-results-of-the-protect-trial
#18
Ali Khoynezhad, Jacob DelaRosa, Marc R Moon, William T Brinkman, Richard B Thompson, Nimesh D Desai, S Chris Malaisrie, Leonard N Girardi, Joseph E Bavaria, T Brett Reece
BACKGROUND: This study intended to evaluate the safety and hemostatic efficacy of a novel vascular sealant (Tridyne™ , Neomend, Inc., Irvine, CA) compared to an accepted adjunctive hemostatic agent applied to aortotomy and sutures lines in cardiovascular surgery. METHODS: Subjects undergoing aortic valve replacement, ascending aortic replacement and/or aortic root replacement were randomized 2:1 to Tridyne™ (n =107) or Gelfoam®+ (Gelfoam®+, Baxter Healthcare Corp...
January 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29324173/the-risk-of-deterioration-in-gcs13-15-patients-with-traumatic-brain-injury-identified-by-computed-tomography-imaging-a-systematic-review-and-meta-analysis
#19
Carl Marincowitz, Fiona E Lecky, William Townend, Aditya Borakati, Andrea Fabbri, Trevor A Sheldon
The optimal management of mild traumatic brain injury (TBI) patients with injuries identified by computed tomography (CT) brain scan is unclear. Some guidelines recommend hospital admission for an observation period of at least 24 h. Others argue that selected lower-risk patients can be discharged from the Emergency Department (ED). The objective of our review and meta-analysis was to estimate the risk of death, neurosurgical intervention, and clinical deterioration in mild TBI patients with injuries identified by CT brain scan, and assess which patient factors affect the risk of these outcomes...
January 11, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29318027/diagnostic-performances-of-two-rapid-tests-for-detection-of-feline-leukemia-virus-antigen-in-sera-of-experimentally-feline-leukemia-virus-infected-cats
#20
Matthew R Krecic, Sridhar Velineni, Patrick Meeus, Huihao Fan, Michael Loenser
Objectives: The objective of this study was to compare the diagnostic sensitivities and specificities of WITNESS FeLV-FIV (Zoetis) and SNAP FIV/FeLV Combo Test (IDEXX) for the detection of FeLV p27 antigen in the sera of experimentally feline leukemia virus (FeLV)-infected cats. Methods: Diagnostic sensitivities of WITNESS and SNAP were determined through testing of 47 serum samples collected from cats day 56 post-experimental infection with a virulent FeLV Rickard strain...
January 2018: JFMS Open Reports
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