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Sunay Shah, Ryan Gindi, Mir B Basir, Akshay Khandelwal, Mohammad Alqarqaz, Mohammad Zaidan, Michele Voeltz, Gerald Koenig, Henry E Kim, William W O'Neill, Khaldoon Alaswad
INTRODUCTION: The purpose of the study is to develop an optimal TR-Band weaning strategy while minimizing vascular access site complications of hematoma or radial artery occlusion (RAO). METHODS: The trial was a randomized, prospective, single center study of 129 patients who underwent cardiac catheterization via the radial artery. Group A was an accelerated protocol in which weaning was initiated 20 min after sheath removal. Group B was an adjusted protocol, in which weaning was dependent on the amount of anti-platelet or anti-coagulation used...
April 14, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Matthew Lindeblad, Alexander Lyubimov, Richard van Breemen, Kamil Gierszal, Guy Weinberg, Israel Rubinstein, Douglas L Feinstein
Patients exposed to long acting anticoagulant rodenticides (LAARs) are typically administered large amounts of oral vitamin K1 (VK1) to counteract life-threatening anti-coagulant effects. While VK1 treatment effectively prevents mortality, additional methods are needed to reduce the long duration of VK1 treatment which can last for months at high expense. We developed a model of brodifacoum (BDF) poisoning, one of the most potent LAARs, in adult male New Zealand White (NZW) rabbits. The LD50 for oral BDF was determined to be 192 μg/kg, similar to that calculated for adult rats...
June 12, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Romain Siriez, Jonathan Evrard, Jean-Michel Dogné, Lionel Pochet, Damien Gheldof, Bernard Chatelain, François Mullier, Jonathan Douxfils
INTRODUCTION:  Betrixaban is a novel direct oral factor Xa inhibitor approved by the Food and Drug Administration for prophylaxis of venous thromboembolism in adult patients hospitalized for an acute illness at risk for thromboembolic complications. Assessment of the anti-coagulant effect of betrixaban may be useful in some situations. Also, clinicians need to know how routine coagulation assays are influenced. OBJECTIVE:  The aim of this study is to determine which coagulation assay(s) should be used to assess the impact of betrixaban on haemostasis and provide laboratory guidance for their interpretation...
June 11, 2018: Thrombosis and Haemostasis
Shahnawaz Rajpar, Bilal Surya, Khalil Mobin, Santosh Kumar
To share the experience of 100 cases of Transurethral Resection of Prostate (TURP), This cross-sectional study was conducted in the Department of Urology, SMBBMC and Lyari General Hospital, Karachi from 1.1.13 to 30.4.15. One hundred cases were selected through purposive sampling. Patients who underwent TURP were included. Those with two life threatening co-morbidities, positive urine culture and patients on anti coagulant medications were excluded from the study. Mean age of the patients was 66±6.2 years with minimum 60 years and maximum 85 years...
May 2018: JPMA. the Journal of the Pakistan Medical Association
Karin du Plessis, Rebecca Peters, Ingrid King, Kirsty Robertson, Jonathan Mackley, Rachel Maree, Tracy Stanley, Louise Pickford, Brian Rose, Matthew Orchard, Helen Stewart, Yves d'Udekem
Background: Families of children at the worst end of the congenital heart disease endure a significant burden which is often not clearly delineated in the clinical literature. We examined the greatest concerns of parents whose children have a Fontan circulation. Methods: Parents ( N  = 107) of children in the Australian and New Zealand Fontan Registry completed online surveys with open-ended and closed questions. A qualitative method approach incorporating thematic analyses was used...
March 2018: IJC Heart & Vasculature
Wael Sumaya, William A E Parker, Rebekah Fretwell, Ian R Hall, David S Barmby, James D Richardson, Javaid Iqbal, Zulfiquar Adam, Kenneth P Morgan, Julian P Gunn, Annah E Mason, Heather M Judge, Christopher P Gale, Ramzi A Ajjan, Robert F Storey
Delayed onset of action of oral P2Y12 inhibitors in ST-elevation myocardial infarction (STEMI) patients may increase the risk of acute stent thrombosis. Available parenteral anti-thrombotic strategies, to deal with this issue, are limited by added cost and increased risk of bleeding. We investigated the pharmacodynamic effects of a novel regimen of enoxaparin in STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Twenty patients were recruited to receive 0.75 mg/kg bolus of enoxaparin (pre-PPCI) followed by infusion of enoxaparin 0...
June 6, 2018: Thrombosis and Haemostasis
Joshua Payne, Trent Bickel, Sandeep Gautam
BACKGROUND: Ablation for atrial fibrillation (AF) requires multiple venous sheaths and anticoagulation with heparin, both risk factors for bleeding complications. Manual compression (MC) with heparin reversal is the standard method to achieve venous hemostasis post ablation, however temporary figure-of-eight sutures (F8S) are an alternative. While this technique has been shown to be safe and effective, little is known about its effect on post-procedural recovery time. METHODS: In this retrospective cohort study, consecutive patients who underwent AF radiofrequency ablation over a 23 month period were reviewed for type of hemostasis (manual compression or figure-of-eight suture), demographics, peri-procedural anticoagulation, groin complications, and procedural duration...
June 5, 2018: Pacing and Clinical Electrophysiology: PACE
Derk Pol, Claire Curtis, Satish Ramukumar, Logan Bittinger
The management of stroke risk in patients with non-valvular atrial fibrillation has changed over the past few years. This change has occurred due to the introduction of novel oral anticoagulants (NOACs) such as apixaban, rivaroxaban and dabigatran for the management of non-valvular atrial fibrillation. These agents have shown comparable stroke risk reduction to warfarin in large international multicentre trials [1-3]. This has changed the clinical practice of many treating physicians since their introduction from 2011 to 2013...
March 22, 2018: Heart, Lung & Circulation
Charlotte Goldfine, Catherine Glazer, Richard M Ratzan
Spontaneous spinal epidural hematoma (SSEH) is a rare diagnosis. One known risk factor is anti-coagulation medication. We present a case of SSEH in a 74-year-old male on rivaroxaban therapy who clinically presented with an intermittently resolving and then worsening neurological exam. Due to the extremely high morbidity and mortality associated with this diagnosis, it is important to be aware of the various presentations and adverse effects related to novel anticoagulation.
May 2018: Clinical practice and cases in emergency medicine
Jianrong Wu, Yuanchong Zhao, Jin Wang, Tianxue You, Nan Huang
Here we report the anticoagulant property of Sulfonated Silk Fibroin (SSF) which was improved by sulfonation method. Chlorosulfonic acid was applied to modify the Silk Fibroin (SF) anticoagulant property by the preparation of the SSF. The SSF was prepared in the new technology that 50°C, 0.2 g SF/ml chlorosulfonic acid and 15 h were optimized with the reaction temperature, special concentration ratio of the SF to the chlorosulfonic acid and the certain reaction time, respectively. Then the SF reaction solution was dialyzed, and freeze-dried to form the SSF...
May 30, 2018: Journal of Biomaterials Science. Polymer Edition
Cecilia Nalli, Valentina Somma, Laura Andreoli, Thomas Büttner, Peter Schierack, Michael Mahler, Dirk Roggenbuck, Angela Tincani
PURPOSE: Anti-phospholipid antibodies (aPL) analyzed by line immunoassay (LIA) can recognize beta2 -glycoprotein I (β2 GPI) domain 1 (D1) epitopes depending on β2 GPI binding to distinct phospholipids. The aPL LIA was compared with consensus ELISA to investigate whether both techniques can discriminate anti-phospholipid syndrome (APS) patients from aPL-positive, systemic autoimmune rheumatic diseases (SARD) patients without clinical symptoms of APS and controls. METHODS: Thirty-four APS patients (14 arterial/venous thrombosis, 16 pregnancy morbidity, and 4 both), 41 patients with SARD lacking clinical APS criteria but demonstrating positivity for anti-β2 GPI (aβ2 GPI) IgG, and 20 healthy subjects (HS) were tested for aPL to cardiolipin (aCL), phosphatidic acid, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol (aPG), phosphatidylinositol, phosphatidylserine, β2 GPI, prothrombin, and annexin V by LIA...
May 29, 2018: Auto- Immunity Highlights
Yoshiaki Shimizu, Takuya Komura, Takuya Seike, Hitoshi Omura, Tatsuo Kumai, Takashi Kagaya, Hajime Ohta, Atsuhiro Kawashima, Kenichi Harada, Shuichi Kaneko, Masashi Unoura
Since diffuse hepatic hemangiomatosis (DHH) is an extremely rare disease especially in adults, the etiology and natural course of adult-onset DHH has not been well understood. We report a case of DHH complicated with multiple organic dysfunction and Kasabach-Merritt syndrome (KMS) in an 83-year-old female. She presented with mild abdominal distension and laboratory findings revealed thrombocytopenia and abnormal coagulation, indicating disseminated intravascular coagulation (DIC). Enhanced computed tomography revealed diffuse, hypodense hepatic nodules with delayed enhancement involving the whole liver, and multiple hypodense splenic legions...
May 29, 2018: Clinical Journal of Gastroenterology
Ghaleb Khirfan, Vickram Tejwani, Xiaofeng Wang, Manshi Li, Joseph DiDonato, Raed A Dweik, Nicholas Smedira, Gustavo A Heresi
BACKGROUND: High Density Lipoprotein Cholesterol (HDL-C) has various anti-inflammatory, anti-atherogenic, anti-oxidant and anti-coagulant properties that improve vascular function. The utility of HDL-C as a biomarker of severity and predictor of survival was described in patients with pulmonary arterial hypertension (PAH). No prior study has assessed the utility of HDL-C in patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH). OBJECTIVES: We aim to measure HDL-C levels in CTEPH patients and compare it to those in PAH patients and controls and determine HDL-C associations with markers of disease severity, hemodynamics and mortality in CTEPH...
2018: PloS One
Raji Atchudan, Thomas Nesakumar Jebakumar Immanuel Edison, Kanikkai Raja Aseer, Suguna Perumal, Yong Rok Lee
The present work illustrates the potential uses of nitrogen-doped multi-fluorescent carbon dots (N-CDs) for Fe3+ sensing, cellular multi-colour imaging, and fluorescent ink. N-CDs were synthesized using Magnolia liliiflora flower by the simple hydrothermal method. The resulted N-CDs was found to be nearly spherical in shape with the size of about 4 ± 1 nm and showed competitive quantum yield around 11%. The synthesized N-CDs with uniform size distribution and high content of nitrogen and oxygen-bearing functional groups exhibit excellent dispersibility in aqueous media...
May 17, 2018: Colloids and Surfaces. B, Biointerfaces
Béatrice Catieau, Véronique Devos, Sami Chtourou, Delphine Borgel, Jean-Luc Plantier
Antithrombin (AT) binds in vitro and in vivo to endothelial cells through various receptors, including heparan sulphate glycosaminoglycan (HSPG) that could modulate the AT activity. A thrombin generation assay (TGA) was set up at the surface of HUVEC and HMVEC evaluating their participation in the coagulation-anticoagulation processes. TGA induced by 0.5 pM Tissue Factor was performed in normal or AT-deficient plasma spiked with various amounts of recombinant or plasma-derived AT (0, 0.1, 0.5 and 1.0 U/ml)...
May 17, 2018: Thrombosis Research
Jingjing Zhou, Zehai Song, Mingshu Han, Baoxing Yu, Guanghui Lv, Na Han, Zhihui Liu, Jun Yin
Zhi-Xiong Capsules (ZXC) involving Hirudo, Ligusticum chuanxiong, Salvia miltiorrhiza, Leonurus artemisia, and Pueraria lobata, is an empirical prescription used in Chinese clinics applied for treating cerebral arteriosclerosis and blood-stasis in clinic. However, the mechanism of its antithrombotic activity has not been investigated until now. The present study was designed to investigate its antithrombotic effects, the mechanism of ZXC on anti-thrombus action and to identify the main chemical composition of ZXC using HPLC-DAD-ESI-IT-TOF-MS...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jie Xia, Cheng-Yan Li, Hui Wang, Qi-Mei Zhang, Zhong-Mou Han
Epilepsy is a common and devastating neurological disorder. Inflammatory processes and apoptosis in brain tissue have been reported in human epilepsy. Scoparone (6,7-dimethoxycoumarin) is an important chemical substance, which has multiple beneficial activities, including antitumor, anti-inflammatory and anti-coagulant properties. In our present study, we attempted to investigate if scoparone could attenuate seizures-induced blood brain barrier breakdown, inflammation and apoptosis. Pilocarpine (Pilo) and methylscopolamine were used to establish acute seizure animal model...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Emanuela de Cillis, Tommaso Acquaviva, Pasquale D'Alessandro, Alessandro Santo Bortone
Cryptogenic stroke is the final diagnosis in almost 40% of ischemic acute cerebrovascular events. There is currently no definitive clinical evidence that percutaneous closure of patent foramen ovale (PFO) can prevent the recurrence of stroke or transient ischemic attack (TIA). Identification of the causes of neurologic ischemic syndromes is essential for any strategy intended to prevent the catastrophic consequences of cerebral infarction. Since the initial reports of an unexpectedly high prevalence of PFO in younger patients with cryptogenic stroke in 1988, there has been growing interest and experience in diagnosing and treating these patients, both medically and/or with percutaneous closure, in particular for the potential to eliminate paradoxical embolism via PFO, which is a likely mechanism for stroke in these patients...
June 1, 2018: Surgical Technology International
Lyndsey Thiessen, Sarah MacDonell, Chris Wall, Preman Jacob, Ahmed Shoker, Michael A J Moser
Renal vein thrombosis in a transplanted kidney is an uncommon but critical complication that can result in graft loss if management is delayed. A 31-year-old male with known atresia of the inferior vena cava who received a deceased donor renal transplant 7 years previously presented to hospital with severe graft site pain and a week of nausea, vomiting, and chills. Serum creatinine was markedly elevated from baseline. Sonographic examination revealed external iliac vein thrombosis with extension of the thrombus into the transplant renal vein...
May 22, 2018: CEN Case Reports
Gunnar H Heine, Vincent Brandenburg, Stephan H Schirmer
BACKGROUND: Cardiological societies recommend, in their guidelines, that patients with atrial fibrillation and an intermediate (or higher) risk of stroke and systemic embolization should be treated with oral anticoagulant drugs. For patients who do not have mitral valve stenosis or a mechanical valve prosthesis, non-vitamin-K dependent oral anticoagulants (NOAC) are preferred over vitamin K antagonists (VKA) for this purpose. It is unclear, however, whether patients with chronic kidney disease and atrial fibrillation benefit from oral anticoagulation to the same extent as those with normal kidney function...
April 27, 2018: Deutsches Ärzteblatt International
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