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https://www.readbyqxmd.com/read/27828690/immunoglobulin-g4-related-thyroid-disorders-diagnostic-challenges-and-clinical-outcomes
#1
Deep Dutta, Arvind Ahuja, Chitra Selvan
Ig-G4 related disease (IgG4RD) is a heterogeneous disorder with multi-organ involvement recognised as a separate entity at the start of this century only. It is currently one of the hottest areas of clinical and translational research across specialties. Thyroid involvement in IgG4RD is rare, believed to occur in less than 4% of cases, may be isolated or may be associated with other organ involvement. As of today Riedel's thyroiditis, fibrosing variant of Hashimoto's thyroiditis, and few patients of Graves' orbitopathy represent the types of IgG4-related thyroid disease (IgG4RTD)...
2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27814726/absolute-volume-of-the-rectum-and-auc-from-rectal-dvh-between-25gy-and-50gy-predict-acute-gastrointestinal-toxicity-with-ig-imrt-in-prostate-cancer
#2
Céline Mirjolet, Paul M Walker, Mélanie Gauthier, Cécile Dalban, Suzanne Naudy, Frédéric Mazoyer, Etienne Martin, Philippe Maingon, Gilles Créhange
BACKGROUND: To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). METHODS: A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC25-50). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC25-50 and the appearance of any acute GI toxicity...
November 4, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27770477/ige-and-allergen-specific-immunotherapy-induced-igg4-recognize-similar-epitopes-of-bet%C3%A2-v%C3%A2-1-the-major-allergen-of-birch-pollen
#3
Nicole Groh, Christian Seutter von Loetzen, Brinda Subbarayal, Christian Möbs, Lothar Vogel, Andreas Hoffmann, Kay Fötisch, Anna Koutsouridou, Stefanie Randow, Elke Völker, Andreas Reuter, Paul Rösch, Stefan Vieths, Wolfgang Pfützner, Barbara Bohle, Dirk Schiller
BACKGROUND: Allergen-specific immunotherapy (AIT) with birch pollen generates Bet v 1-specific immunoglobulin (Ig)G4 which blocks IgE-mediated hypersensitivity mechanisms. Whether IgG4 specific for Bet v1a competes with IgE for identical epitopes or whether novel epitope specificities of IgG4 antibodies are developed is under debate. OBJECTIVE: We sought to analyze the epitope specificities of IgE and IgG4 antibodies from sera of patients who received AIT. METHODS: 15 sera of patients (13/15 received AIT) with Bet v 1a-specific IgE and IgG4 were analyzed...
October 22, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27726003/the-immunobiology-of-immunoglobulin-g4-and-complement-activation-pathways-in-igg4-related-disease
#4
Shigeyuki Kawa
High serum immunoglobulin (Ig) G4 concentration and abundant IgG4-bearing plasma cell infiltration are characteristic features in autoimmune pancreatitis (AIP). AIP is also complicated with a variety of other organ involvements that commonly share marked IgG4-bearing plasma cell infiltration, suggesting the existence of a systemic disease associated with IgG4 currently recognized as IgG4-related disease (IgG4-RD). However, it is controversial whether IgG4 plays a role in the pathogenesis of AIP or IgG4-RD through such characteristic attributes as Fab-arm exchange and rheumatoid factor (RF)-like activity...
September 21, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27382941/comparing-the-type-and-severity-of-inflammatory-bowel-disease-in-relation-to-igg4-immunohistochemical-staining
#5
COMPARATIVE STUDY
H D Şimşek, S Basyigit, B Aktas, E Vargol, G G Şimşek, M Küçükazman, Y Nazlıgül
BACKGROUD AND STUDY AIM: The role of immunoglobulin (Ig) G4 in the etiopathogenesis of inflammatory bowel disease (IBD) and its association with endoscopic and pathological activity are not yet completely understood. The purpose of this study was to determine the possible relationship between IgG4 status and IBD. PATIENTS AND METHODS: Endoscopic colon biopsies of 55 patients with ulcerative colitis (UC) and of 17 patients with Crohn's disease (CD) were examined...
April 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27144724/the-safety-and-efficacy-of-nivolumab-for-the-treatment-of-advanced-renal-cell-carcinoma
#6
Moshe C Ornstein, Brian I Rini
INTRODUCTION: Despite a variety of therapies for advanced advanced renal cell carcinoma (RCC) including vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors, outcomes for these patients are still not optimal. Immunotherapy with checkpoint inhibitors such as nivolumab, a fully human immunoglobulin (Ig) G4 PD-1 inhibitor antibody, is a promising development in RCC and provides a new therapeutic option for patients with advanced disease...
June 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27106428/presumed-second-focus-of-lung-immunoglobulin-g4-related-disease-found-to-be-adenocarcinoma
#7
Gregory D Scott, David A Sauer, Kirsten M Woolf, Mithran S Sukumar, Brandon H Tieu
We describe a patient presenting with bilateral radiologically similar lung lesions initially diagnosed as immunoglobulin (Ig) G4-related disease from biopsy of one lesion, but radiographic changes 6 months later prompted biopsy of the second lesion and showed adenocarcinoma. No case of lung IgG4-related disease and a distant lung malignancy has been previously reported. This is notable because lung IgG4-related disease often manifests in multiple thoracic locations but is diagnosed from a representative biopsy specimen...
May 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27053971/igg4-related-lung-disease-associated-with-usual-interstitial-pneumonia
#8
Frank Schneider, Kristen L Veraldi, Marc C Levesque, Thomas V Colby, Eunhee S Yi
We report a case of immunoglobulin(Ig)G4-related disease with the radiologic and histopathological manifestations resembling usual interstitial pneumonia (UIP). The patient was a 62-year-old man who presented with progressive dyspnea of insidious onset. High resolution computed tomography of the chest showed lower-lobe predominant peripheral reticulation and traction bronchiectasis but no honeycomb change. Microscopic examination of the surgical lung biopsy showed characteristic features of UIP including architectural distortion by fibrosis with peripheral and paraseptal accentuation, scattered fibroblast foci and microscopic honeycomb change...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27037774/nodules-behind-the-ears-igg4-related-skin-disease
#9
M Kondo, S Yamamoto, H Goto, Y Nara
A 53-year-old healthy factory worker consulted our hospital complaining of small nodules of similar size, shape and location on both ears. The nodules revealed focal and massive infiltration of lymphocytes, plasma cells and eosinophils with fibrosis. They had no specific structure on pathological staining with haematoxylin and eosin. Immunostaining for IgG4 revealed that a large majority of the IgG(+) cells were positive for IgG4. The ratio of IgG4(+) to IgG(+) plasma cells was approximately 40%. IgG4(+) plasma cells were present at approximately 250 per high-power field...
November 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/26990055/igg4-related-disease-retrospective-analysis-of-one-hundred-sixty-six-patients
#10
Hiroshi Sekiguchi, Ryohei Horie, Mio Kanai, Reina Suzuki, Eunhee S Yi, Jay H Ryu
OBJECTIVE: To investigate clinical and pathologic aspects of IgG4-related disease (IgG4-RD) in non-Asian populations. METHODS: We conducted a retrospective review of the medical records of patients with IgG4-RD who presented to an academic medical center from January 1994 to September 2012. RESULTS: Among 166 patients identified, the median age at diagnosis was 61 years (interquartile range [IQR] 49-70 years), 75% were male, and 80% were white...
September 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26984819/a-g4%C3%A2-k-hydrogel-that-self-destructs
#11
Taylor N Plank, Jeffery T Davis
A G4-quartet based hydrogel formed by self-assembly of borate esters of 5'-deoxy-5'-iodoguanosine (5'-IG 2) undergoes in situ cyclization to give 5'-deoxy-N3,5'-cycloguanosine (5'-cG 3). Formation of 5'-cG 3 causes self-destruction of the gel. This intramolecular cyclization can be used to release nucleoside analogs that have been pre-incorporated into the gel network.
April 11, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/26910221/five-top-stories-in-thyroid-pathology
#12
REVIEW
Parnian Ahmadi Moghaddam, Renu Virk, Ali Sakhdari, Manju L Prasad, Ediz F Cosar, Ashraf Khan
CONTEXT: Thyroid carcinoma is the most common malignant tumor of endocrine organs, yet it only accounts for approximately 1% of all cancers in the United States with more than 35,000 new cases diagnosed each year and more than 450,000 people living with this disease. While most tumors can be diagnosed without much difficulty, a few tumor types, especially tumors with follicular pattern, sometimes pose a diagnostic challenge. OBJECTIVE: To discuss morphologic, immunohistochemical, and molecular features of thyroid tumors...
February 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/26904579/a-case-of-immunoglobulin-g4-related-constrictive-pericarditis
#13
Wen-Qi Luo, Fang Fang, Wen-Jun Zhen, Xiao-Kang Ouyang, Huai-Bin Wang, Zi Wang, You Zhong
A 47-year-old man was admitted with a complaint of upper abdominal distension and shortness of breath. The constrictive pericarditis was diagnosed based on the transthoracic echocardiogram (TTE) and chest CT scan. Pathology revealed it is immunoglobulin (Ig) G4-related constrictive pericarditis. Likely, this is the first case of IgG4-related constrictive pericarditis reported in China.
February 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/26468313/how-to-diagnose-immunoglobulin-g4-associated-cholangitis-the-jack-of-all-trades-in-the-biliary-tract
#14
REVIEW
Lowiek M Hubers, Ulrich Beuers
BACKGROUND: Immunoglobulin (Ig) G4-associated cholangitis (IAC) is an inflammatory disorder of the biliary tract displaying characteristic features of IgG4-related disease (IgG4-RD): elevation of IgG4 serum levels, infiltration of IgG4+ plasma cells in the affected tissue, and good response to immunosuppressive treatment. METHODS AND RESULTS: The clinical presentation of IAC is often misleading, mimicking other diseases of the biliary tract such as cholangiocarcinoma or primary and secondary sclerosing cholangitis...
June 2015: Viszeralmedizin
https://www.readbyqxmd.com/read/26433704/il-18-is-highly-expressed-in-inflammatory-infiltrates-of-submandibular-glands-in-patients-with-immunoglobulin-g4-related-disease
#15
Takeshi Komori, Satoru Kondo, Naohiro Wakisaka, Yosuke Nakanishi, Sayaka Nakanishi-Yagi, Akira Tsuji, Kazuhira Endo, Shigeyuki Murono, Tomokazu Yoshizaki
Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a new disease entity characterized by high serum IgG4 concentrations, infiltration of IgG4-positive plasmacytes, and fibrosis of various organs. Several groups have reported that IgG4-RD is a unique inflammatory disorder characterized by an immune reaction predominantly mediated by T helper (Th) 2 and regulatory T cells. Meanwhile, recent studies have demonstrated that interleukin (IL) 18 has a potential to trigger the production of Th2 cytokines by Th1 cells...
December 2015: Human Pathology
https://www.readbyqxmd.com/read/26392854/elevated-serum-igg4-levels-in-two-cases-of-paragonimiasis
#16
Sho Saeki, Yuko Horio, Susumu Hirosako, Hidenori Ichiyasu, Kazuhiko Fujii, Hirotsugu Kohrogi
Paragonimiasis is a parasitic pleuropulmonary infection caused by eating raw crustaceans and wild boar meat and this infection is endemic in Asia. We herein report two cases of pulmonary P aragonimus westermani infection associated with elevated levels of serum immunoglobulin (Ig) G4 and dense infiltration of IgG4-positive plasma cells in the lung lesions. Treatment with praziquantel resolved the pulmonary lesions and decreased the serum levels of IgG4. IgG4-related disease is a systemic disease occasionally involving the lungs and leads to increased serum levels of IgG4...
September 2015: Respirology Case Reports
https://www.readbyqxmd.com/read/26381653/igg4-related-stomach-muscle-lesion-with-a-renal-pseudotumor-and-multiple-renal-rim-like-lesions-a-rare-manifestation-of-igg4-related-disease
#17
Koichi Inoue, Takehiko Okubo, Takashi Kato, Kazuo Shimamura, Teruji Sugita, Mitsuhiro Kubota, Kohji Kanaya, Daisuke Yamachika, Makoto Sato, Dai Inoue, Kenichi Harada, Mitsuhiro Kawano
We describe a 74-year-old man with immunoglobulin G4-related disease (IgG4-RD) presenting with gastric cancer, stomach and kidney lesions. For 15 years, the patient had been treated under a diagnosis of sclerosing cholangitis, which was revealed to be IgG4-RD only when the cancer was found. Histology revealed the gastric cancer and IgG4-related lesion in the muscularis propria to be separate. This case suggests that the stomach muscle can also be a site of involvement of IgG4-RD.
September 18, 2015: Modern Rheumatology
https://www.readbyqxmd.com/read/26381446/immunoglobulin-g4-associated-autoimmune-hepatitis-later-complicated-by-autoimmune-pancreatitis-a-case-report
#18
Yoji Ishizu, Masatoshi Ishigami, Teiji Kuzuya, Takashi Honda, Kazuhiko Hayashi, Isao Nakano, Yoshiki Hirooka, Hidemi Goto
Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) is a new disease entity with elevated levels of serum IgG4 and marked IgG4 positive plasma cell infiltration of the liver, and its clinical course remains unknown. A patient with IgG4-associated AIH who later developed autoimmune pancreatitis (AIP) is reported. A 73-year-old man was admitted to our hospital due to elevated liver transaminase levels, hypergammaglobulinemia and positive antinuclear antibody. A liver biopsy specimen showed severe interface hepatitis with marked lymphoplasmacytic infiltration without damage to the interlobular bile ducts, and a diagnosis of AIH was made...
May 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/26377996/loss-of-interleukin-21-leads-to-atrophic-germinal-centers-in-multicentric-castleman-s-disease
#19
Hidetaka Yajima, Motohisa Yamamoto, Yui Shimizu, Nodoka Sakurai, Chisako Suzuki, Yasuyoshi Naishiro, Kohzoh Imai, Yasuhisa Shinomura, Hiroki Takahashi
Both multicentric Castleman's disease (MCD) and immunoglobulin (Ig)G4-related disease (IgG4-RD) are systemic diseases, presenting with hypergammaglobulinemia and elevated serum levels of IgG4. However, with regard to histopathological findings, MCD shows atrophic germinal centers. On the other hand, expanded germinal centers are detected in IgG4-RD. We extracted germinal centers from specimens of each disorder by microdissection and analyzed the expression of mRNAs by real-time polymerase chain reaction to clarify the mechanisms underlying atrophied germinal centers in MCD...
January 2016: Annals of Hematology
https://www.readbyqxmd.com/read/26376649/treatment-against-human-endogenous-retrovirus-a-possible-personalized-medicine-approach-for-multiple-sclerosis
#20
François Curtin, Hervé Perron, Raphael Faucard, Hervé Porchet, Alois B Lang
Human endogenous retroviruses (HERV) represent about 8 % of the human genome. Some of these genetic elements are expressed in pathological circumstances. A HERV protein, the multiple sclerosis-associated retrovirus (MSRV) envelope protein (MSRV-Env), is expressed in the blood and active brain lesions of multiple sclerosis (MS) patients. It possesses pro-inflammatory and myelinotoxic properties. The patterns of expression and pathogenic properties of MSRV-Env make it a relevant drug target for MS therapeutics-in particular for preventing neurodegeneration, a key component of progressive forms of MS...
October 2015: Molecular Diagnosis & Therapy
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