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https://www.readbyqxmd.com/read/27919214/hydrogel-based-drug-delivery-systems-a-review-with-special-emphasis-on-challenges-associated-with-decontamination-of-hydrogels-and-biomaterials
#1
Irene Satiko Kikuchi, Raquel Galante, Kamal Dua, Daniela Dal Molim Ghisleni, Terezinha de Jesus Andreoli Pinto, Venkata Ramana Malipeddi, Rajendra Awasthi
Many researches involving the development of new techniques and biomaterials to formulate a suitable drug delivery systems and tissue engineering have been conducted. The majority of published literature from these researches emphasizes the production and materials characterization. However there is very limited information regarding their sterilization methods. The present review article has summarized various different literatures that encompasses the difficulties encountered with sterilization methods in the preparations of hydrogels for biological applications...
December 5, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27904107/epidermoid-cyst-in-an-intrapancreatic-accessory-spleen-case-report-and-literature-review-of-the-preoperative-imaging-findings
#2
Shin Kato, Hideki Mori, Moriya Zakimi, Koki Yamada, Kenji Chinen, Masayuki Arashiro, Susumu Shinoura, Kaoru Kikuchi, Takahiro Murakami, Fumihito Kunishima
An epidermoid cyst arising within an intrapancreatic accessory spleen (ECIAS) is rare, and also difficult to correctly diagnose before surgery. It is mostly misdiagnosed as a cystic tumor, such as a mucinous cystic neoplasm or as a solid tumor with cystic degeneration, such as a neuro endocrine tumor. We herein report a case of ECIAS and also perform a literature review of 35 reports of ECIAS. Although the preoperative diagnosis of ECIAS using conventional imaging is relatively difficult to make, careful preoperative examinations of the features on computed tomography and magnetic resonance imaging could lead to a correct preoperative diagnosis of ECIAS which might thereby reduce the number of unnecessary resections...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27903179/gamma-knife-radiosurgery-for-brain-metastases-from-pulmonary-large-cell-neuroendocrine-carcinoma-a-japanese-multi-institutional-cooperative-study-jlgk1401
#3
Takuya Kawabe, Masaaki Yamamoto, Yasunori Sato, Shoji Yomo, Takeshi Kondoh, Osamu Nagano, Toru Serizawa, Takahiko Tsugawa, Hisayo Okamoto, Atsuya Akabane, Kazuyasu Aita, Manabu Sato, Hidefumi Jokura, Jun Kawagishi, Takashi Shuto, Hideya Kawai, Akihito Moriki, Hiroyuki Kenai, Yoshiyasu Iwai, Masazumi Gondo, Toshinori Hasegawa, Soichiro Yasuda, Yasuhiro Kikuchi, Yasushi Nagatomo, Shinya Watanabe, Naoya Hashimoto
OBJECTIVE In 1999, the World Health Organization categorized large cell neuroendocrine carcinoma (LCNEC) of the lung as a variant of large cell carcinoma, and LCNEC now accounts for 3% of all lung cancers. Although LCNEC is categorized among the non-small cell lung cancers, its biological behavior has recently been suggested to be very similar to that of a small cell pulmonary malignancy. The clinical outcome for patients with LCNEC is generally poor, and the optimal treatment for this malignancy has not yet been established...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27886865/two-cases-of-pseudo-achalasia-with-lung-cancer-case-report-and-short-literature-review
#4
Taizou Hirano, Eisaku Miyauchi, Akira Inoue, Ryotaro Igusa, Shigeki Chiba, Kazuhiro Sakamoto, Hisatoshi Sugiura, Toshiaki Kikuchi, Masakazu Ichinose
Pseudo-achalasia with lung cancer is a rare complication. We present 2 cases of pseudo-achalasia with lung cancer and summarize previous reports. The previous reports suggested that lung cancer can be complicated with pseudo-achalasia caused by paraneoplastic neurological syndromes rather than direct invasion of the tumor cells to the lower esophageal sphincter, irrespective of the histology of the lung cancer; this can strongly influence the performance status. Treatment for pseudo-achalasia improves not only the symptoms, but also the performance status...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27882617/heritability-estimates-of-muscle-strength-related-phenotypes-a-systematic-review-and-meta-analysis
#5
H Zempo, E Miyamoto-Mikami, N Kikuchi, N Fuku, M Miyachi, H Murakami
The purpose of this study was to clarify the heritability estimates of human muscle strength-related phenotypes (H(2) -msp). A systematic literature search was conducted using PubMed (through August 22, 2016). Studies reporting the H(2) -msp for healthy subjects in a sedentary state were included. Random-effects models were used to calculate the weighted mean heritability estimates. Moreover, subgroup analyses were performed based on phenotypic categories (eg, grip strength, isotonic strength, jumping ability)...
November 23, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27847377/underestimated-amoebic-appendicitis-among-hiv-1-infected-individuals-in-japan
#6
Taiichiro Kobayashi, Koji Watanabe, Hideaki Yano, Yukinori Murata, Toru Igari, Kumiko Nakada-Tsukui, Kenji Yagita, Tomoyoshi Nozaki, Mitsuo Kaku, Kunihisa Tsukada, Hiroyuki Gatanaga, Yoshimi Kikuchi, Shinichi Oka
Entamoeba histolytica is not a common causative agent of acute appendicitis. However, amoebic appendicitis could sometimes be severe and life-threatening, mainly due to lack of awareness. Also, its frequency, clinical features and pathogenesis remain unclear. The study subjects were HIV-1-infected individuals who presented with acute appendicitis and later underwent appendectomy at our hospital between 1996 and 2014. Formalin-fixed paraffin-embedded preserved appendix specimens were re-examined by Periodic acid-Schiff (PAS) staining and PCR to identify undiagnosed amoebic appendicitis...
November 9, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27825686/usefulness-of-endobronchial-ultrasonography-with-a-guide-sheath-and-virtual-bronchoscopic-navigation-for-ground-glass-opacity-lesions
#7
Yasuyuki Ikezawa, Naofumi Shinagawa, Noriaki Sukoh, Megumi Morimoto, Hajime Kikuchi, Masahiro Watanabe, Kosuke Nakano, Satoshi Oizumi, Masaharu Nishimura
BACKGROUND: Endobronchial ultrasonography with guide sheath (EBUS-GS) could be useful for diagnosing ground-glass opacity (GGO) predominant-type lesions in the peripheral lung. Furthermore, several studies have reported that transbronchial biopsy using EBUS-GS and virtual bronchoscopic navigation (VBN) was safe and effective for diagnosing small peripheral lung lesions. Our objectives were to diagnose solitary peripheral GGO predominant-type lesions by transbronchial biopsy using EBUS-GS and VBN under radiographic fluoroscopic guidance, and to evaluate the clinical factors associated with diagnostic yield...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27788176/effectiveness-of-continuum-of-care-linking-pre-pregnancy-care-and-pregnancy-care-to-improve-neonatal-and-perinatal-mortality-a-systematic-review-and-meta-analysis
#8
Kimiyo Kikuchi, Sumiyo Okawa, Collins O F Zamawe, Akira Shibanuma, Keiko Nanishi, Azusa Iwamoto, Yu Mon Saw, Masamine Jimba
PROSPERO International prospective register of systematic reviews (CRD42015023424).
2016: PloS One
https://www.readbyqxmd.com/read/27777431/kikuchi-fujimoto-disease-complicated-with-reactive-hemophagocytic-lymphohistiocytosis
#9
Masatake Nishiwaki, Hideharu Hagiya, Toru Kamiya
Kikuchi-Fujimoto disease (KFD) is a benign cause of self-limiting subacute necrotizing lymphadenitis. KFD is rarely complicated with reactive hemophagocytic lymphohistiocytosis (HLH), and the clinical features of the simultaneous occurrence of these conditions are uncertain. A 30-year-old Japanese man with a persistent fever and sore throat presented to our hospital for treatment. Laboratory analysis showed bicytopenia, and radiological studies showed systemic lymphadenopathy accompanied by splenomegaly. A bone marrow examination showed hemophagocytic macrophages, suggesting HLH...
October 2016: Acta Medica Okayama
https://www.readbyqxmd.com/read/27738893/imaging-characteristics-of-the-postoperative-globe-a-pictorial-essay
#10
Yusuke Ito, Ikuo Yamazaki, Yoichi Kikuchi, Eri O'uchi, Toshihiro O'uchi, Hiroaki Kato, Kazuki Hotta
Recognizing imaging characteristics after ophthalmic surgery is necessary for radiologists to prevent misdiagnosis. We review typical appearances of intraorbital implanted devices and materials on CT and MRI with demonstration of the common surgical procedures. EX-PRESS glaucoma filtration devices appear as punctate areas of metal attenuation on CT and are typically placed at the corneoscleral junction. The imaging manifestations after cataract extraction are absence of the native lens of ovoid mass and the intraocular lens with high attenuation on CT and low signal intensity on MRI...
December 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27735163/kikuchi-fujimoto-s-disease-clinicopathological-correlation
#11
Sainath K Andola, Anshuman Sinha, Sangram Biradar
Kikuchi-Fujimoto's disease is a benign, self-limiting disorder characterized by regional tender lymphadenopathy fever and night sweats. It most commonly affects Asian adult females younger than 40 years of age. We report a case of 26 year female who presented with cervical lymphadenopathy, which on FNAC revealed Necrotizing Granulomatous inflammation which was unresponsive for three months of antitubercular therapy. A diagnosis of Kikuchi Fujimoto's disease was suggested on review of the slides at our institute and a biopsy confirmed the diagnosis...
May 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27689023/human-case-of-bacteremia-due-to-streptococcus-suis-serotype-5-in-japan-the-first-report-and-literature-review
#12
Daisuke Taniyama, Mayu Sakurai, Tetsuya Sakai, Takahide Kikuchi, Takashi Takahashi
Streptococcus suis is a zoonotic pathogen that can be transferred from pigs to humans. The serotypes 2 and 14 are prevalent among patients with S. suis infections, while other serotypes (i.e., 1, 4, 5, 16, and 24) have been detected in rare human cases. To the best of our knowledge, the present patient handling with raw pork is the first human case of uncomplicated bacteremia due to S. suis serotype 5 in Japan. We confirmed the new sequence type 752 of this isolate. Virulence-associated gene profiling was performed; both sly (encoding the hemolysin suilysin) and mrp (encoding a muramidase-released protein) were detected without amplification of epf (encoding the extracellular factor)...
2016: IDCases
https://www.readbyqxmd.com/read/27636188/3d-turbo-field-echo-with-diffusion-sensitized-driven-equilibrium-preparation-technique-dsde-tfe-versus-echo-planar-imaging-in-evaluation-of-diffusivity-of-retinoblastoma
#13
Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Hiroshi Yoshikawa, Makoto Obara, Hiroshi Honda
OBJECTIVE: Compared with echoplanar (EP) diffusion-weighted imaging (DWI), three-dimensional (3D) turbo field echo with diffusion-sensitized driven-equilibrium (DSDE-TFE) preparation DWI obtains images with higher spatial resolution and less susceptibility artefacts. The purpose of this study was to evaluate the feasibility of DSDE-TFE to visualize retinoblastomas compared with EP imaging. METHODS: This retrospective study was approved by our institutional review boards...
November 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27604375/epidemiology-diagnosis-preoperative-evaluation-and-prognostic-assessment-of-upper-tract-urothelial-carcinoma-utuc
#14
Francesco Soria, Shahrokh F Shariat, Seth P Lerner, Hans-Martin Fritsche, Michael Rink, Wassim Kassouf, Philippe E Spiess, Yair Lotan, Dingwei Ye, Mario I Fernández, Eiji Kikuchi, Daher C Chade, Marko Babjuk, Arthur P Grollman, George N Thalmann
PURPOSE: Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this article was to review the previous literature to summarize the current knowledge about UTUC epidemiology, diagnosis, preoperative evaluation and prognostic assessment. METHODS: Using MEDLINE, a non-systematic review was performed including articles between January 2000 and February 2016. English language original articles, reviews and editorials were selected based on their clinical relevance...
September 7, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27590477/determining-when-to-stop-prostate-specific-antigen-monitoring-after-radical-prostatectomy-the-role-of-ultrasensitive-prostate-specific-antigen
#15
Kazuhiro Matsumoto, Akari Komatsuda, Yoshinori Yanai, Naoya Niwa, Takeo Kosaka, Ryuichi Mizuno, Eiji Kikuchi, Akira Miyajima, Mototsugu Oya
PURPOSE: We analyzed long-term followup data after radical prostatectomy to determine how long we should follow patients in whom the serum prostate specific antigen level measured by an ultrasensitive assay was consistently low. MATERIALS AND METHODS: We retrospectively reviewed clinicopathological data for 582 consecutive patients who underwent open or laparoscopic radical prostatectomy between 1995 and 2004, excluding 4 patients who received adjuvant therapy. We stratified the patients according to prostate specific antigen at 3 and 5 years after surgery, and examined subsequent biochemical recurrence (elevation of prostate specific antigen to greater than 0...
August 30, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27579249/retroseptal-transconjunctival-approach-for-blowout-fracture-of-the-orbital-floor-an-ideal-choice-in-east-asian-patients
#16
Tetsuji Uemura, Takahiro Chuman, Tatsuya Fujii, Aya Morikawa, Mamoru Kikuchi, Hidetaka Watanabe
OBJECTIVE: To ask experts in the field to evaluate a surgeon's experience with a retroseptal transconjunctival approach for the repair of the orbital floor damaged by blowout fracture that the surgeon encountered in 12 East-Asian patients. METHODS: Patients were identified from a database, and a retrospective case note review was conducted. A total of 12 conjunctival procedures were conducted for the repair of blowout fracture with no other complicating fractures...
May 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27577925/the-epidemiology-of-adverse-drug-events-and-medication-errors-among-psychiatric-inpatients-in-japan-the-jade-study
#17
Nobutaka Ayani, Mio Sakuma, Takeshi Morimoto, Toshiaki Kikuchi, Koichiro Watanabe, Jin Narumoto, Kenji Fukui
BACKGROUND: Knowledge of the epidemiology of adverse drug events (ADEs) and medication errors in psychiatric inpatients is limited outside Western countries. The nature of ADEs and medication errors are important for improving the quality of care worldwide; therefore, we conducted the Japan Adverse Drug Events Study, a series of cohort studies at several settings in Japan. METHODS: This report included 448 inpatients with 22,733 patient-days in a psychiatric hospital and psychiatric units at a tertiary care teaching hospital over 1 year...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27572127/endogenous-mechanisms-of-cardiac-regeneration
#18
M S W Xiang, K Kikuchi
Zebrafish possess a remarkable capacity for cardiac regeneration throughout their lifetime, providing a model for investigating endogenous cellular and molecular mechanisms regulating myocardial regeneration. By contrast, adult mammals have an extremely limited capacity for cardiac regeneration, contributing to mortality and morbidity from cardiac diseases such as myocardial infarction and heart failure. However, the viewpoint of the mammalian heart as a postmitotic organ was recently revised based on findings that the mammalian heart contains multiple undifferentiated cell types with cardiogenic potential as well as a robust regenerative capacity during a short period early in life...
2016: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/27523100/the-influence-of-american-society-of-anesthesiologists-physical-status-on-patient-morbidity-and-survival-after-total-thyroidectomy
#19
Shogo Shinohara, Masahiro Kikuchi, Hiroyuki Harada, Shinji Takebayashi, Kazuma Yunoki, Kazuo Yamazaki
In cases of thyroid papillary carcinoma, a less aggressive cancer, surgeons may hesitate to perform total thyroidectomy on patients with poor general condition because these may experience longer survival without undergoing surgery. To investigate the influence of general patient condition on the patients' survival who received total thyroidectomy, we utilized the American Society of Anesthesiologists Physical Status (ASA-PS). We retrospectively reviewed all patients undergoing total thyroidectomy under general anesthesia and graded by ASA-PS between 2004 and 2014...
November 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27514842/a-case-of-ovarian-adenosquamous-carcinoma-arising-from-endometrioid-adenocarcinoma-a-case-report-and-systematic-review
#20
Tadahiro Shoji, Eriko Takatori, Kazuyuki Murakami, Yoshitaka Kaido, Satoshi Takeuchi, Akihiko Kikuchi, Toru Sugiyama
BACKGROUND: The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature. METHODS: We describe a case in which a 57-year-old woman had stage IC ovarian cancer histologically diagnosed as adenosquamous carcinoma. We also systematically reviewed the literature using the PubMed database. CASE PRESENTATION: Preoperative computed tomography and magnetic resonance imaging showed a tumor measuring 14 cm in diameter and containing solid areas...
2016: Journal of Ovarian Research
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