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https://www.readbyqxmd.com/read/28514532/the-dickkopf1-ckap4-axis-creates-a-novel-signaling-pathway-and-may-represent-a-molecular-target-for-cancer-therapy
#1
REVIEW
Akira Kikuchi, Katsumi Fumoto, Hirokazu Kimura
Dickkopf 1 (DKK1) is a secretory protein and antagonizes oncogenic Wnt signaling by binding to the Wnt co-receptor low-density lipoprotein receptor-related proteins 6 (LRP6). DKK1 is also suggested to regulate its own signaling to associate with tumor aggressiveness. However, the underlying mechanism by which DKK1 promotes cancer cell proliferation has remained to be clarified for a long time. It has been recently found that cytoskeleton-associated protein 4 (CKAP4), which was originally reported as an endoplasmic reticulum membrane protein, acts as a novel DKK1 receptor...
May 17, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28469876/ammonium-acid-urate-urolithiasis-in-anorexia-nervosa-a-case-report-and-literature-review
#2
Mina Fukai, Tetsu Hirosawa, Hideo Nakatani, Tomoko Muramatsu, Mitsuru Kikuchi, Yoshio Minabe
Ammonium acid urate urolithiasis is a quite rare condition. Our literature review of ammonium acid urate urolithiasis suggests that ammonium acid urate urolithiasis should be regarded as a general medical complication related to anorexia nervosa, and purging by laxative abuse might be a crucially important risk.
May 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28453808/long-term-pulmonary-function-after-surgery-for-lung-cancer
#3
Naohiro Kobayashi, Keisuke Kobayashi, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Katsuyuki Endo, Yukio Sato
OBJECTIVES: Many patients with lung cancer have been cured by surgical intervention. However, the long-term effects of lung resection on pulmonary function are unclear. Therefore, we investigated long-term pulmonary function after surgery. METHODS: We retrospectively reviewed the medical records of patients who underwent surgery for lung cancer between 2001 and 2009. A total of 445 patients who had survived more than 5 years since the surgery were included. The patients were divided into lobectomy, segmentectomy and partial resection groups...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453639/perioperative-morbidity-and-mortality-of-octogenarians-treated-by-radical-cystectomy-a-multi-institutional-retrospective-study-in-japan
#4
Takashige Abe, Norikata Takada, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Naoto Miyajima, Satoru Maruyama, Nobuo Shinohara
Objective: To determine the characteristics of 90-day morbidity and mortality after radical cystectomy in Japanese octogenarians. Methods: A retrospective multi-institutional study. We reviewed the records of 834 patients treated by open radical cystectomy between 1997 and 2010. All complications within 90 days after surgery were sorted into the 11 categories proposed by the Memorial Sloan-Kettering Cancer Center and graded according to the modified Clavien-Dindo system...
April 27, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28374057/early-diagnosis-of-pancreatic-necrosis-based-on-perfusion-ct-to-predict-the-severity-of-acute-pancreatitis
#5
Yoshihisa Tsuji, Naoki Takahashi, Hiroyoshi Isoda, Koji Koizumi, Sho Koyasu, Miho Sekimoto, Yuichi Imanaka, Shujiro Yazumi, Masanori Asada, Yoshihiro Nishikawa, Hiroshi Yamamoto, Osamu Kikuchi, Tsukasa Yoshida, Tetsuro Inokuma, Shinji Katsushima, Naoki Esaka, Akihiro Okano, Chiharu Kawanami, Nobuyuki Kakiuchi, Masahiro Shiokawa, Yuzo Kodama, Ichiro Moriyama, Takafumi Kajitani, Yoshikazu Kinoshita, Tsutomu Chiba
BACKGROUND: Perfusion CT can diagnose pancreatic necrosis in early stage of severe acute pancreatitis, accurately. However, no study to date has examined whether early diagnosis of pancreatic necrosis is useful in predicting persistent organ failure (POF). METHODS: We performed a multi-center prospective observational cohort study to investigate whether perfusion CT can predict the development of POF in the early stage of AP, based on early diagnosis of the development of pancreatic necrosis (PN)...
April 3, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28346642/nasal-oral-and-pharyngolaryngeal-manifestations-of-pemphigus-vulgaris-endoscopic-ororhinolaryngologic-examination
#6
Masafumi Ohki, Shigeru Kikuchi
Pemphigus vulgaris is an autoimmune blistering disorder that involves the skin and mucous membranes. Few reports have described nasal and oropharyngolaryngeal lesions in pemphigus vulgaris using an endoscopic ororhinolaryngologic examination. We retrospectively reviewed the clinical records of 11 patients with pemphigus vulgaris between 2001 and 2013 with respect to their symptoms, lesion sites, lesion features, and treatments received. All patients had undergone an endoscopic ororhinolaryngologic examination...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28329064/perioperative-outcomes-of-off-pump-minimally-invasive-coronary-artery-bypass-grafting-with-bilateral-internal-thoracic-arteries-under-direct-vision%C3%A2
#7
Keita Kikuchi, Xufa Chen, Makoto Mori, Atsushi Kurata, Liang Tao
OBJECTIVES: We previously introduced techniques to harvest and use the right internal thoracic artery in minimally invasive coronary artery bypass grafting (CABG) via a single left thoracotomy for revascularization with bilateral internal thoracic arteries (BITA). We report our short-term outcomes of patients who underwent minimally invasive CABG using BITA and a single internal thoracic artery (SITA). METHODS: Consecutive patients who underwent minimally invasive CABG using BITA or SITA at a Japanese medical center between February 2012 and December 2015 were reviewed retrospectively...
January 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28317587/prolonged-pneumoperitoneum-time-is-an-independent-risk-factor-for-intravesical-recurrence-after-laparoscopic-radical-nephroureterectomy-in-upper-tract-urothelial-carcinoma
#8
Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
OBJECTIVE: To evaluate the impact of pneumoperitoneum time on intravesical recurrence (IVR) in upper tract urothelial carcinoma (UTUC) patients who underwent laparoscopic radical nephroureterectomy (LRNU). PATIENTS AND METHODS: We identified 129 UTUC patients who underwent LRNU at our three institutions from 2004 to 2014. We evaluated the association of IVR rate and patient clinico-pathological characteristics including operation time. By retrospectively reviewing all videotapes, we defined pneumoperitoneum time as being from the infusion of pressurized CO2 gas with a pressure of 10-12 mmHg to extirpation of the kidney...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28279633/kikuchi-fujimoto-disease-a-rare-cause-of-lymphadenopathy-in-africa-description-of-the-first-case-in-senegal-and-review-of-the-literature
#9
C-A Lame, B Loum, A-K Fall, J Cucherousset, A-R Ndiaye
INTRODUCTION: Kikuchi-Fujimoto disease, or histiocytic necrotizing lymphadenitis, is a benign disease most commonly affecting adult females. It generally presents in the form of febrile cervical lymphadenopathy. This diagnosis must be considered in the setting of tropical medicine, dominated by a high prevalence of tuberculous lymphadenitis and haematological malignancies. CASE REPORT: The authors report the case of a 33-year-old Senegalese woman who presented with subacute cervical lymphadenopathy associated with fever and laboratory signs of inflammation...
March 6, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28216371/atp-binding-cassette-transporters-in-tumor-endothelial-cells-and-resistance-to-metronomic-chemotherapy
#10
Kyoko Hida, Hiroshi Kikuchi, Nako Maishi, Yasuhiro Hida
Drug resistance is a major problem in anticancer therapy. ATP-binding cassette (ABC) transporters have a role in the multidrug resistance. A new regimen of chemotherapy has been proposed, called "metronomic chemotherapy". Metronomic chemotherapy is the frequent, regular administration of drug doses designed to maintain low, but active, concentrations of chemotherapeutic drugs over prolonged periods of time, without causing serious toxicities. Metronomic chemotherapy regimens were developed to optimize the antitumor efficacy of agents that target the tumor vasculature instead of tumor cells, and to reduce toxicity of antineoplastic drugs [1]...
February 16, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28215361/osteochondroma-of-the-tibial-sesamoid-a-case-report-and-review-of%C3%A2-the-literature
#11
Kazuo Ouchi, Michiyuki Hakozaki, Shin-Ichi Kikuchi, Shoji Yabuki, Shin-Ichi Konno
Osteochondroma, one of the most common benign bone tumors, frequently occurs in the metaphysis of the long bones. We report an extremely rare case of osteochondroma that occurred in the tibial sesamoid. The patient was a 62-year-old Japanese male. He presented with a 1-year history of pain and a hard mass on the plantar aspect of the right forefoot sole. The osteochondroma protruded toward the sole from the tibial sesamoid, leading to pain on weightbearing. After tibial sesamoidectomy, the patient's symptoms were eliminated, and no pain or complications such as hallux valgus occurred after the surgery...
February 15, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28213730/impact-of-baseline-visceral-fat-accumulation-on-prognosis-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-systemic-therapy
#12
Ryuichi Mizuno, Akira Miyajima, Taizo Hibi, Aya Masuda, Toshiaki Shinojima, Eiji Kikuchi, Masahiro Jinzaki, Mototsugu Oya
The aim of this study was to evaluate the clinical significance of visceral fat accumulation as a prognostic factor in patients with metastatic renal cell carcinoma (mRCC) treated with systemic therapies. A total of 114 patients were retrospectively reviewed. All patients received systemic therapy for mRCC at Keio University hospital in Japan. The intra-abdominal visceral fat area was determined by computed tomography at the umbilical level. The visceral fat accumulation was defined as ≥100 cm(2). The mean visceral fat area was 107...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28097371/high-resolution-diffusion-weighted-imaging-for-solitary-orbital-tumors-3d-turbo-field-echo-with-diffusion-sensitized-driven-equilibrium-dsde-tfe-preparation-technique
#13
Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Hiroshi Yoshikawa, Makoto Obara, Hiroshi Honda
PURPOSE: To differentiate cystic from solid solitary intraorbital tumors using 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation without contrast material. MATERIALS AND METHODS: This retrospective study was approved by our institutional review boards, and written informed consent was waived. A total of 26 patients with intraorbital tumors were studied. Motion probing gradients were conducted at one direction with b‑values of 0 and 500 s/mm(2)...
January 17, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28097116/kikuchi-fujimoto-disease-misdiagnosed-as-relapse-of-the-infection-after-treatment-of-periprosthetic-hip-joint-infection
#14
Kyung-Keun Min, Byung-Woo Min, Kyung-Jae Lee, Jung-Hoon Choi
Periprosthetic joint infection (PJI) of the hip can be difficult to treat and can lead to a number of problems including: i) severe functional decline of the hip joint and ii) increasing financial burden for patients due to long treatment periods and the need for repeated surgical interventions. Because there is risk of inadequate control of infection or relapse of a preexisting infection following the treatment of PJI through surgery, it is important to closely observe clinical symptoms such as systemic fever...
December 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/28065394/characterizing-intermediate-risk-non-muscle-invasive-bladder-cancer-implications-for-the-definition-of-intermediate-risk-and-treatment-strategy
#15
Kazuhiro Matsumoto, Eiji Kikuchi, Yoshinori Yanai, Nozomi Hayakawa, Yujiro Ito, Takahiro Maeda, Hirohiko Nagata, Akira Miyajima, Mototsugu Oya
PURPOSE: Patients with intermediate-risk non-muscle-invasive bladder cancer have traditionally been defined as those not included in the low- or high-risk groups. Therefore, the intermediate-risk group consists of heterogeneous patients. MATERIALS AND METHODS: We reviewed 326 patients diagnosed with intermediate-risk tumors. We subclassified these patients into 3 groups according to their clinical courses. Group A included patients with initial and multiple low-grade tumors (N = 170)...
January 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28053143/arl4c-is-a-key-regulator-of-tubulogenesis-and-tumourigenesis-as-a-target-gene-of-wnt-%C3%AE-catenin-and-growth-factor-ras-signalling
#16
REVIEW
Shinji Matsumoto, Shinsuke Fujii, Akira Kikuchi
Epithelial tubular morphogenesis (tubulogenesis) is a fundamental morphogenetic process of many epithelial organs. In this developmental process, epithelial cells migrate, proliferate, polarize and differentiate towards surrounding mesenchymal tissue to form tubule structures. Although epithelial tissue structures are basically stable in the postnatal period, epithelial cells regain highly proliferative and invasive potentials within mesenchymal tissue during tumour formation (tumourigenesis). Therefore, there must be a common molecular basis orchestrating the cellular behaviours involved in both tubulogenesis and tumourigenesis...
January 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/27998053/ultrasonographic-findings-of-kikuchi-cervical-lymphadenopathy-in-children
#17
Ji Young Kim, Hyunju Lee, Bo La Yun
PURPOSE: The purpose of this study was to analyze the ultrasonographic (USG) findings of Kikuchi cervical lymphadenopathy in pediatric patients. METHODS: Between April 2007 and September 2016, 84 children (42 male and 42 female; mean±standard deviation age, 12.9±3.2 years; range, 5 to 18 years) confirmed with Kikuchi disease were enrolled. Clinical findings and USG findings of Kikuchi cervical lymphadenopathy were retrospectively reviewed. Localized symptoms, systemic symptoms, and laboratory findings including the white blood cell count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were analyzed...
January 2017: Ultrasonography
https://www.readbyqxmd.com/read/27995017/influence-of-physician-years-on-urological-journal-publication-productivity-among-japanese-urologists
#18
Naoya Niwa, Eiji Kikuchi, Kazuhiro Matsumoto, Akira Miyajima, Mototsugu Oya
PURPOSE: To evaluate the urological journal publication productivity of Japanese urologists based on their physician years. METHODS: All original articles written by Japanese urologists and published from Japanese institutions in 6 primary urological journals between 2010 and 2014 were reviewed (N = 529 articles). RESULTS: The median post-graduate years of the first and corresponding authors of all articles were 16 and 21 years, respectively...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27965151/riptortus-pedestris-and-burkholderia-symbiont-an-ideal-model-system-for-insect-microbe-symbiotic-associations
#19
REVIEW
Kazutaka Takeshita, Yoshitomo Kikuchi
A number of insects establish symbiotic associations with beneficial microorganisms in various manners. The bean bug Riptortus pedestris and allied stink bugs possess an environmentally acquired Burkholderia symbiont in their midgut crypts. Unlike other insect endosymbionts, the Burkholderia symbiont is easily culturable and genetically manipulatable outside the host. In conjunction with the experimental advantages of the host insect, the Riptortus-Burkholderia symbiosis is an ideal model system for elucidating the molecular bases underpinning insect-microbe symbioses, which opens a new window in the research field of insect symbiosis...
April 2017: Research in Microbiology
https://www.readbyqxmd.com/read/27919214/hydrogel-based-drug-delivery-systems-a-review-with-special-emphasis-on-challenges-associated-with-decontamination-of-hydrogels-and-biomaterials
#20
Irene Satiko Kikuchi, Raquel Sofia Cardoso Galante, Kamal Dua, Venkata Ramana Malipeddi, Rajendra Awasthi, Daniela Dal Molim Ghisleni, Terezinha de Jesus Andreoli Pinto
Many researches involving the development of new techniques and biomaterials to formulate a suitable drug delivery systems and tissue engineering have been conducted. The majority of published literature from these researches emphasizes the production and materials characterization. However there is very limited information regarding their sterilization methods. The present review article has summarized various different literatures that encompasses the difficulties encountered with sterilization methods in the preparations of hydrogels for biological applications...
December 5, 2016: Current Drug Delivery
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