Zhanna Evgrafova, Bruno Voigt, Andreas H Roos, Gerd Hause, Dariush Hinderberger, Jochen Balbach, Wolfgang H Binder
A substantial number of diseases leading to loss of neurologic functions such as Morbus Alzheimer, Morbus Parkinson, or Chorea Huntington are related to the fibrillation of particular amyloidogenic peptides. In vitro amyloid fibrillation strongly depends on admixture with other proteins and peptides, lipids, nanoparticles, surfactants and polymers. We investigated amyloid-beta 1-40 peptide (Aβ1-40 ) fibrillation in mixture with thermoresponsive poly(oligo(ethylene glycol)m acrylates), in which the polymer's hydrophobicity is tuned by variation of the number of ethylene glycol-units in the side chain (m = 1-9), the end groups (B = butoxy; C = carboxy; D = dodecyl; P = pyridyldisulfide) and the degree of polymerization (n) of the polymers...
October 7, 2019: Physical Chemistry Chemical Physics: PCCP