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Morbus Parkinson

A Grözinger, Y Rommelspacher, D C Wirtz, K Sander, R Pflugmacher
BACKGROUND: The incidence of Morbus Parkinson (MP) increases with age. An increasing number of patients with MP in the orthopaedic patient population is expected. In the case of general surgery and trauma surgery MP in patients was identified as an important factor for perioperative morbidity. This study investigates the influence of MP on the perioperative course of patients after elective lumbar fusion. PATIENTS AND METHODS: A retrospective matched-pairs analysis with 17 patients in each group was conducted with patients treated in the department of spinal surgery in an orthopaedic university hospital for symptomatic degenerative lumbar spine disease without improvement after conservative therapy...
June 2015: Zeitschrift Für Orthopädie und Unfallchirurgie
Corina Wilding, Katharina Bell, Sabine Beck, Sebastian Funke, Norbert Pfeiffer, Franz H Grus
The family of synuclein proteins (α, β and γ) are related to neurodegenerative disease e.g. Parkinson disease and Morbus Alzheimer. Additionally, a connection between γ-synuclein and glaucoma, a neurodegenerative disease characterized by a progressive loss of retinal ganglion cells, which finally leads to blindness, exists. The reason for the development of glaucoma is still unknown. Recent studies evaluating the participation of immunological components, demonstrate complex changed antibody reactivities in glaucoma patients in comparison to healthy people, showing not only up-regulations (e...
2014: PloS One
Pika Miklavc, Konstantin Ehinger, Kristin E Thompson, Nina Hobi, Derya R Shimshek, Manfred Frick
Leucine-rich repeat kinase 2 (LRRK2) is known to play a role in the pathogenesis of various diseases including Parkinson disease, morbus Crohn, leprosy and cancer. LRRK2 is suggested to be involved in a number of cell biological processes such as vesicular trafficking, transcription, autophagy and lysosomal pathways. Recent histological studies of lungs of LRRK2 knock-out (LRRK2 -/-) mice revealed significantly enlarged lamellar bodies (LBs) in alveolar type II (ATII) epithelial cells. LBs are large, lysosome-related storage organelles for pulmonary surfactant, which is released into the alveolar lumen upon LB exocytosis...
2014: PloS One
J Siewe, K Zarghooni, M Röllinghoff, C Herren, T Koy, P Eysel, R Sobottke
BACKGROUND: Adult central movement disorders, malpostures, and scolioses can have their cause in various neurological underlying diseases such as Morbus Parkinson, Pisa syndrome, or segmental dystonia. Important clinical characteristics are marked postural distortions such as camptocormia (bent spine) or laterocollis. In cases of these adult scolioses, surgical spine treatment puts high demands on the surgeon. Surgery in Parkinson's disease, for example, is associated with serious surgery-specific as well as general complications...
October 2013: Zeitschrift Für Orthopädie und Unfallchirurgie
Holger Steinberg
Since the 1980s and 1990s, vagus nerve and deep brain stimulation, transcranial magnetic stimulation and cranial electrotherapy stimulation have found their way into neurology as therapeutic approaches to epilepsy, Morbus Parkinson and other central nervous symptoms. Moreover, these methods have proven useful and provided hope in the therapy of other diseases, most of all in psychiatry. From a historic perspective, this new emphasis on somatic therapies in the case of transcranial magnetic stimulation and cranial electrotherapy stimulation represents the return of therapeutic methods widely used in the 19th century and based on very similar techniques...
April 2011: Brain: a Journal of Neurology
R Hakimi
In Germany about 300,000 to 400,000 people are suffering from Morbus Parkinson at present. It is one of the most common neurological diseases both in Germany and in Europe as a whole. With the rising number of elderly people in our population, the number of Parkinson patients will strongly increase as well in future. About 20% of these patients are already in an advanced stage. This stage leaves its marks with motor and non-motor sequelae. With the minority of these patients oral medication is ineffective. For these relatively rare cases an indication for an L-dopa-infusion therapy (duodopa pump), an apomorphine pump therapy or a deep brain stimulation may exist...
December 1, 2010: Versicherungsmedizin
Bianca Da Costa Dias, Katarina Jovanovic, Stefan F T Weiss
Neurodegenerative diseases are caused by proteinaceous aggregates, usually consisting of misfolded proteins which are often typified by a high proportion of β-sheets, which accumulate in the Central Nervous System. These diseases, including Morbus Alzheimer, Parkinson disease and Transmissible Spongiform Encephalopathies (TSEs)--also termed prion disorders--afflict a substantial proportion of the human population and as such the etiology and pathogenesis of these diseases has been the focus of mounting research...
January 2011: Prion
L Timmermann, F Maier, C Eggers, M Schmidt, E Kalbe
Cognitive decline is a common disorder in idiopathic Parkinson's syndrome, the risk for the development of a dementia is four- to six-fold higher for Parkinsonian patients. The cognitive profile in Parkinson's disease dementia (PDD) differs from that of Alzheimer-type dementias. The affected cognitive functions include attention, executive functions, visual-spatial functions and recall. The main differential diagnosis for PDD is the Lewy body dementia (LBD), which can be differentiated through the temporal development of motor and cognitive symptoms...
September 2010: Fortschritte der Neurologie-Psychiatrie
Magdalena Misiak, Cordian Beyer, Susanne Arnold
Many neurodegenerative diseases, such as Morbus Parkinson, exhibit a gender-dependency showing a higher incidence in men than women. Most of the neurodegenerative disorders involve either causally or consequently a dysfunction of mitochondria. Therefore, neuronal mitochondria may demonstrate a gender-specificity with respect to structural and functional characteristics of these organelles during toxic and degenerative processes. The application of 6-OHDA (6-hydroxydopamine) in vitro and in vivo represents a well-accepted experimental model of Parkinson's disease causing Parkinsonian symptoms...
June 2010: Biochimica et Biophysica Acta
J P Parkinson
No abstract text is available yet for this article.
1918: Proceedings of the Royal Society of Medicine
J P Parkinson
No abstract text is available yet for this article.
1909: Proceedings of the Royal Society of Medicine
Sonja von Campenhausen, Yaroslav Winter, Julia Gasser, Klaus Seppi, Jens-P Reese, Karl-P Pfeiffer, Sabine Geiger-Gritsch, Kai Bötzel, Uwe Siebert, Wolfgang H Oertel, Richard Dodel, Werner Poewe
OBJECTIVE: The objective of this study was to analyse the costs and the situation of care in patients with idiopathic Parkinson's disease (PD) in Austria. Continuously increasing healthcare costs and the fact that the prevalence of PD is expected to double in the next 25 years highlight the importance of health-economic evaluation in PD. METHOD: Patient survey with 81 patients with idiopathic Parkinson's disease. A bottom-up approach has been used to calculate direct and indirect costs from a societal perspective...
2009: Wiener Klinische Wochenschrift
G Pusswald, M Fleck, D Haubenberger, E Auff, G Weber
PURPOSE OF THE STUDY: In this study the relevance of sense of coherence (SOC) for coping with an illness was examined in subjects with Parkinson's disease. According to Antonovsky's model (1997) the sense of coherence is an important resource when it comes to dealing with stressors. To take into consideration the integrated view of Parkinson patients, severity of the illness (UPDRS) was determined by the neurologist and tendency toward depression was recorded. METHOD: 51 patients with PD (mean age: 67...
June 2009: Zeitschrift Für Gerontologie und Geriatrie
F W Bergert, D Conrad, K Ehrenthal, J Fessler, J Gross, K Gundermann, B Kluthe, W Lang Heinrich, A Liesenfeld, P G Loew, E Luther, R Pchalek, J Seffrin, A Sterzing, H-J Wolfring, U Zimmermann
The part "Special pharmacology of the aged" of this guideline contains recommendations for typical conditions in the family doctors practice: in the January issue 2009 dementia and Morbus Parkinson, in this issue osteoporosis and urinary incontinence and in the next issue rectal incontinence and obstipation. This issue of the IJCPT contains the third part of the Pharmacotherapy guidelines for the aged by family doctors for family doctors. Part 3: Osteoporosis and urinary incontinence. Osteoporosis is a systematic disease characterized by low bone mass and declining bone structure...
March 2009: International Journal of Clinical Pharmacology and Therapeutics
A Steffen, J Hagenah, H Graefe, M Mahlerwein, B Wollenberg
BACKGROUND: The use of continuous positive airway pressure (CPAP) is well established in treatment of moderate and severe obstructive sleep apnea syndrome (OSAS). The judgement of clinical symptoms like daytime sleepiness and hypersomnolence with loss in concentration is complicated in patients with diagnosis of Morbus Parkinson (MP) because the disease itself and pharmacologic therapy may mimic clinical features of OSAS. PATIENTS AND METHODS: Diagnostic pathways and differential diagnostic considerations are demonstrated in two case reports of patients with MP and OSAS...
February 2008: Laryngo- Rhino- Otologie
M Baron, A P Kudin, W S Kunz
There is compelling evidence for the direct involvement of mitochondria in certain neurodegenerative disorders, such as Morbus Parkinson, FRDA (Friedreich's ataxia), ALS (amyotrophic lateral sclerosis), and temporal lobe epilepsy with Ammon's horn sclerosis. This evidence includes the direct genetic evidence of pathogenic mutations in mitochondrial proteins in inherited Parkinsonism {such as PARK6, with mutations in the mitochondrial PINK1 [PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1]} and in FRDA (with mutations in the mitochondrial protein frataxin)...
November 2007: Biochemical Society Transactions
Georges C Stergiou, Joachim A Obwegeser, Klaus W Gräz, Roger A Zwahlen
Unilateral or bilateral dislocation of the TMJ is frequent. Usually it can be treated by the method described by Hippocrates. If conservative treatment (splint therapy, biofeedback, etc.) does not succeed related to recurrent fixed TMJ-dislocation, surgical therapy strategies become necessary. Above all mentally retarded or patients with neuromuscular disorders may necessitate surgical treatment. The two surgical main procedures are: 1. Removal of mechanical obstacles by reduction of the eminentia. 2. Creation of a mechanical obstacle towards the anterior condylar translation...
2007: Revue Mensuelle Suisse D'odonto-stomatologie
T A Sontag, C Heim, W Kolasiewicz, J Horn, I Pardowitz, K H Sontag
The consequences of short phases of restricted cerebral blood flow and iron enrichment of striatal tissues resulted in an animal model that could correspond to the basic features of a model for Parkinson's disease. An automatic and computerized hole-board offers simultaneous data on learning and cognitive memory capabilities, learning of distinct patterns of distributed food pellets found and eaten in a given time, switches between different locations of food in the holes and in different layout patterns. Wistar rats after 60 min of bilateral clamping of the carotid arteries (BCCA) under pentobarbital anesthesia received 1...
2006: Journal of Neural Transmission. Supplementum
U an der Heiden
It is demonstrated that schizophrenia is a dynamical disease, i. e. that important aspects of schizophrenia can be understood on the basis of concepts of the theory of nonlinear dynamical systems. In particular, the gradual shift of a single parameter may result in completely different kinds of behavior of the entire system just like water can be in three qualitatively different states depending on the single parameter temperature. Transitions between these different states are called bifurcations or phase transitions...
February 2006: Pharmacopsychiatry
Andreas Johannes Schmidt, Jürgen-Christian Krieg, Helmut Vedder
A large number of neurological and psychiatric diseases like Morbus Parkinson, amyotrophic lateral sclerosis, dementia, schizophrenia and probably also affective disorders show an enhanced production of reactive oxygen species. Moreover, alterations of antioxidative systems and beneficial effects of antioxidative substances including steroid compounds such as estrogens have been described in several of these diseases. This review focuses on alterations of antioxidative systems in the course of neurological diseases and psychiatric disorders and on the differential effects of steroids on these systems in the central nervous system...
2005: World Journal of Biological Psychiatry
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