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Fluorescence guided surgery

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https://www.readbyqxmd.com/read/29245052/optical-molecular-imaging-for-tumor-detection-and-image-guided-surgery
#1
REVIEW
Chensu Wang, Zhaohui Wang, Tian Zhao, Yang Li, Gang Huang, Baran D Sumer, Jinming Gao
We have witnessed rapid development of fluorescence molecular imaging of solid tumors for cancer diagnosis and image-guided surgery in the past decade. Many biomarkers unique to cancer cells or tumor microenvironment, such as cell surface receptors, hypoxia, secreted proteases and extracellular acidosis have been characterized, and can be used to distinguish cancer from normal tissue. A variety of optical imaging probes have been developed to target these biomarkers to improve tumor contrast over the background tissue...
December 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/29242021/activatable-fluorescent-probes-in-fluorescence-guided-surgery-practical-considerations
#2
REVIEW
Ai Mochida, Fusa Ogata, Tadanobu Nagaya, Peter L Choyke, Hisataka Kobayashi
Fluorescence-guided imaging during surgery is a promising technique that is increasingly used to aid surgeons in identifying sites of tumor and surgical margins. Of the two types of fluorescent probes, always-on and activatable, activatable probes are preferred because they produce higher target-to-background ratios, thus improving sensitivity compared with always-on probes that must contend with considerable background signal. There are two types of activatable probes: 1) enzyme-reactive probes that are normally quenched but can be activated after cleavage by cancer-specific enzymes (activity-based probes) and 2) molecular-binding probes which use cancer targeting moieties such as monoclonal antibodies to target receptors found in abundance on cancers and are activated after internalization and lysosomal processing (binding-based probes)...
December 5, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29241310/indocyanine-green-fluorescence-guided-sentinel-lymph-node-identification-in-urologic-cancers-a-systematic-review-and-meta-analysis
#3
Fouad Aoun, Simone Albisinni, Marc Zanaty, Toufic Hassan, Gunter Janetschek, Roland van Velthoven
INTRODUCTION: To date, bilateral pelvic lymph node dissection (PLND) represents the most accurate and reliable staging procedure for the detection of lymph node invasion in prostate cancer and bladder cancer. However, the procedure is not devoid of complications. In this field, Indocyanine green fluorescence-guided sentinel lymph node (SLN) identification is an emerging and promising technique, as accurate staging of urologic cancer could be enhanced by a thorough evaluation of the sentinel lymph nodes...
December 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29210533/rapid-differential-diagnosis-of-breast-microcalcification-using-targeted-near-infrared-fluorophores
#4
Min Ho Park, Wonbong Lim, Danbi Jo, Jin Seok Jung, Subin Kim, Jangho Kim, Hyo Soon Lim, Ji Shin Lee, Jung-Joon Min, Hoon Hyun
Early detection and differential diagnosis of breast microcalcifications are of significant importance in effective treatment of early breast cancer, because mineral composition of breast calcification is directly associated with different pathological states. However, applying image-based modalities for component identification in breast calcification remains challenging, because no calcification-specific contrast agent is available to distinguish between benign and malignant (type I and type II, respectively) calcifications of breast lesions...
December 6, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29200846/improved-resection-and-prolonged-overall-survival-with-pd-1-irdye800cw-fluorescence-probe-guided-surgery-and-pd-1-adjuvant-immunotherapy-in-4t1-mouse-model
#5
Yang Du, Ting Sun, Xiaolong Liang, Yuan Li, Zhengyu Jin, Huadan Xue, Yihong Wan, Jie Tian
An intraoperative technique to accurately identify microscopic tumor residuals could decrease the risk of positive surgical margins. Several lines of evidence support the expression and immunotherapeutic effect of PD-1 in breast cancer. Here, we sought to develop a fluorescence-labeled PD-1 probe for in vivo breast tumor imaging and image-guided surgery. The efficacy of PD-1 monoclonal antibody (PD-1 mAb) as adjuvant immunotherapy after surgery was also assessed. PD-1-IRDye800CW was developed and examined for its application in tumor imaging and image-guided tumor resection in an immunocompetent 4T1 mouse tumor model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29191856/psma-11-derived-dual-labeled-psma-inhibitors-for-preoperative-pet-imaging-and-precise-fluorescence-guided-surgery-of-prostate-cancer
#6
Ann-Christin Baranski, Martin Schäfer, Ulrike Bauder-Wüst, Mareike Roscher, Jana Schmidt, Esther Stenau, Tobias Simpfendörfer, Dogu Teber, Lena Maier-Hein, Boris Hadaschik, Uwe Haberkorn, Matthias Eder, Klaus Kopka
Resection of tumor lesions using targeted dual-modality probes combining preoperative imaging with intraoperative guidance is of high clinical relevance and might considerably impact the outcome of prostate cancer therapy. This work aims at the development of dual-labeled prostate specific membrane antigen (PSMA)-inhibitors derived from the established positron emission tomography (PET)- and N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid (HBED-CC) based tracer 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) to allow accurate intraoperative detection of PSMA-positive tumor lesions...
November 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29186607/benefits-and-limitations-of-indocyanine-green-fluorescent-image-guided-surgery-for-spinal-intramedullary-tumors
#7
Toshihiro Takami, Kentaro Naito, Toru Yamagata, Nobuyuki Shimokawa, Kenji Ohata
BACKGROUND: Intraoperative image guidance using near-infrared indocyanine green videoangiography (ICG-VA) has been used to provide real-time angiographic images during vascular or brain tumor surgery, and it is also being used for spine surgery. OBJECTIVE: To further investigate the benefits and limitations of ICG-VA image-guided surgery for spinal intramedullary tumors through retrospective study. METHODS: ICG-VA was used in 48 cases that were treated surgically over the past 5 yr...
December 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29174485/navigation-of-fluorescence-cameras-during-soft-tissue-surgery-is-it-possible-to-use-a-single-navigation-setup-for-various-open-and-laparoscopic-urological-surgery-applications
#8
Matthias N van Oosterom, Philippa Meershoek, Gijs H KleinJan, Kees Hendricksen, Nassir Navab, Cornelis J H van de Velde, Henk G van der Poel, Fijs W B van Leeuwen
PURPOSE: Providing real-time visualization, fluorescence imaging can guide surgeons during tissue resection. Unfortunately, tissue-induced signal-attenuation limits the value of this technique to superficial applications. By positioning the fluorescence camera via a dedicated navigation setup we reason the technology can be made compatible with deeper lying lesions, increasing its impact on clinical care. Such impact would benefit from the ability to implement the navigation technology in different surgical settings...
November 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29156557/the-invasive-region-of-glioblastoma-defined-by-5ala-guided-surgery-has-an-altered-cancer-stem-cell-marker-profile-compared-to-central-tumour
#9
Stuart J Smith, Mohammed Diksin, Saachi Chhaya, Shwetha Sairam, Maria A Estevez-Cebrero, Ruman Rahman
Glioblastoma, a WHO grade IV astrocytoma, is a highly aggressive and heterogeneous tumour that infiltrates deeply into surrounding brain parenchyma, making complete surgical resection impossible. Despite chemo-radiotherapy, the residual cell population within brain parenchyma post-surgery causes inevitable recurrence. Previously, the tumour core has been the focus of research and the basis for targeted therapeutic regimes, which have failed to improve survival in clinical trials. Here, we focus on the invasive margin as defined by the region with 5-aminolevulinic acid (5ALA) (GliolanTM) fluorescence at surgery beyond the T1 enhancing region on magnetic resonance imaging (MRI)...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29153902/robotic-buccal-mucosal-graft-ureteroplasty-for-complex-ureteral-stricture
#10
Sohrab Arora, Logan Campbell, Mouafak Tourojman, Daniel Pucheril, Lamont R Jones, Craig Rogers
OBJECTIVE: To demonstrate robot-assisted ureterolysis and buccal mucosal graft (BMG) ureteroplasty for the management of a complex, long recurrent ureteral stricture developing after ureterolysis, and also to demonstrate the use of near-infrared fluorescence (NIRF) imaging and intraoperative ureteroscopy during this procedure. METHODS: A 58-year-old man with a history of cabergoline treatment and a cardiac catheterization through the left groin presented with left flank pain and hydronephrosis...
December 2017: Urology
https://www.readbyqxmd.com/read/29139243/wide-field-spectrally-resolved-quantitative-fluorescence-imaging-system-toward-neurosurgical-guidance-in-glioma-resection
#11
Yijing Xie, Maria Thom, Michael Ebner, Victoria Wykes, Adrien Desjardins, Anna Miserocchi, Sebastien Ourselin, Andrew W McEvoy, Tom Vercauteren
In high-grade glioma surgery, tumor resection is often guided by intraoperative fluorescence imaging. 5-aminolevulinic acid-induced protoporphyrin IX (PpIX) provides fluorescent contrast between normal brain tissue and glioma tissue, thus achieving improved tumor delineation and prolonged patient survival compared with conventional white-light-guided resection. However, commercially available fluorescence imaging systems rely solely on visual assessment of fluorescence patterns by the surgeon, which makes the resection more subjective than necessary...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29139095/local-alkylating-chemotherapy-applied-immediately-after-5-ala-guided-resection-of-glioblastoma-does-not-provide-additional-benefit
#12
William Sage, Mathew Guilfoyle, Catriona Luney, Adam Young, Rohitashwa Sinha, Donatella Sgubin, Joseph H McAbee, Ruichong Ma, Sarah Jefferies, Rajesh Jena, Fiona Harris, Kieren Allinson, Tomasz Matys, Wendi Qian, Thomas Santarius, Stephen Price, Colin Watts
Grade IV glioma is the most common and aggressive primary brain tumour. Gross total resection with 5-aminolevulinic acid (5-ALA) guided surgery combined with local chemotherapy (carmustine wafers) is an attractive treatment strategy in these patients. No previous studies have examined the benefit carmustine wafers in a treatment programme of 5-ALA guided resection followed by a temozolomide-based chemoradiotherapy protocol. The objective of this study was to examine the benefit of carmustine wafers on survival in patients undergoing 5-ALA guided resection...
November 14, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29129358/indocyanine-green-fluorescence-guided-parathyroidectomy-for-primary-hyperparathyroidism
#13
Jonathan C DeLong, Erin P Ward, Thinzar M Lwin, Kevin T Brumund, Kaitlyn J Kelly, Santiago Horgan, Michael Bouvet
BACKGROUND: Our aim was to evaluate the ease and utility of using indocyanine green fluorescence angiography for intraoperative localization of the parathyroid glands. METHODS: Indocyanine green fluorescence angiography was performed during 60 parathyroidectomies for primary hyperparathyroidism during a 22-month period. Indocyanine green was administered intravenously to guide operative navigation using a commercially available fluorescence imaging system. Video files were graded by 3 independent surgeons for strength of enhancement using an adapted numeric scoring system...
November 9, 2017: Surgery
https://www.readbyqxmd.com/read/29129114/image-guided-surgery-and-therapy-for-lung-cancer-a-critical-review
#14
Keyvan Moghissi, Kate Dixon
Of the many imaging technologies, some have the potential to be used in image-guided surgery and therapy (IGS/IGT). This review of relevant papers on IGS/IGT for lung cancer indicates effective localization and IGS/IGT in early endobronchial lesions by fluorescence bronchoscopic technique. Visualization of early peripheral (nodular) tumors at operation can be achieved by a variety of imaging methods and devices which allow identification, localization and provision of intraoperative real-time images. Recent developments employing fluorescence contrasts and near infra-red light have shown encouraging feasibility and outcome in providing reliable methods for the IGS of cancer generally and lung cancer more specifically with provision of real time intraoperative imaging...
November 13, 2017: Future Oncology
https://www.readbyqxmd.com/read/29121788/fluorescence-image-guided-neurosurgery
#15
Sadao Kaneko, Muftah S Eljamel
Surgery plays an important role in the management of high-grade gliomas (HGG) and imparts significant tumor-free and overall survival advantages. However HGG margins are often invisible, making their gross total resection (GTR) a difficult task. Hence intraoperative technology such as intraoperative fluorescence was a revolutionary discovery. A critical literature review revealed fluorescence improved the GTR of HGG from 36% using standard surgery to 74.5 and 84.4% using aminolevulinic acid (ALA) or fluorescein (FLCN), respectively...
November 2017: Future Oncology
https://www.readbyqxmd.com/read/29121779/image-guided-surgery-in-gynecologic-oncology
#16
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29121778/intraoperative-image-guided-surgery-in-neuro-oncology-with-specific-focus-on-high-grade-gliomas
#17
Syed O Mahboob, Muftah Eljamel
Surgery is paramount in glioma management and extent of resection is an independent significant prognostic factor. However, these tumors are often invisible intraoperatively. Hence imaging plays an important role in surgical guidance. A critical literature review, using MEDLINE/PubMed service was carried out. It demonstrated a gross total resection (GTR) with neuronavigation (NNS) of 31-36%, adding 5-aminolevulinic acid or fluorescein fluorescence, or intraoperative ultrasound or MRI improved GTR to 69.1, 84...
November 2017: Future Oncology
https://www.readbyqxmd.com/read/29110850/nanoparticle-targeted-folate-receptor-1-enhanced-photodynamic-therapy-for-lung-cancer
#18
Tatsuya Kato, Cheng S Jin, Hideki Ujiie, Daiyoon Lee, Kosuke Fujino, Hironobu Wada, Hsin-Pei Hu, Robert A Weersink, Juan Chen, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Brian C Wilson, Gang Zheng, Kazuhiro Yasufuku
OBJECTIVE: Despite modest improvements, the prognosis of lung cancer patients has still remained poor and new treatment are urgently needed. Photodynamic therapy (PDT), the use of light-activated compounds (photosensitizers) is a treatment option but its use has been restricted to central airway lesions. Here, we report the use of novel porphyrin-lipid nanoparticles (porphysomes) targeted to folate receptor 1 (FOLR1) to enhance the efficacy and specificity of PDT that may translate into a minimally-invasive intervention for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29107433/-use-of-indocyanine-green-angiography-in-oncological-and-reconstructive-breast-surgery
#19
S Struk, J-F Honart, Q Qassemyar, N Leymarie, B Sarfati, H Alkhashnam, C Mazouni, F Rimareix, F Kolb
The Indocyanine green (ICG) is a soluble dye that is eliminated by the liver and excreted in bile. When illuminated by an near-infrared light, the ICG emits fluorescence in the near-infrared spectrum, which can be captured by a near-infrared camera-handled device. In case of intravenous injection, ICG may be used as a marker of skin perfusion. In case of interstitial injection, it may be useful for lymphatic network mapping. In oncological and reconstructive breast surgery, ICG is used for sentinel lymph node identification, to predict mastectomy skin flap necrosis, to assess the perfusion of free flaps in autologous reconstruction and for diagnosis and treatment of upper limb secondary lymphedema...
October 26, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29097944/multimodal-imaging-nanoparticles-derived-from-hyaluronic-acid-for-integrated-preoperative-and-intraoperative-cancer-imaging
#20
William M Payne, Tanner K Hill, Denis Svechkarev, Megan B Holmes, Balasrinivasa R Sajja, Aaron M Mohs
Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7...
2017: Contrast Media & Molecular Imaging
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