keyword
MENU ▼
Read by QxMD icon Read
search

Relationship therapy

keyword
https://www.readbyqxmd.com/read/29156731/mir-21-modulates-the-effect-of-ezh2-on-the-biological-behavior-of-human-lung-cancer-stem-cells-in-vitro
#1
Hui Xia, Wen Zhang, Baoshi Zhang, Yingnan Zhao, Yunlong Zhao, Shaojun Li, Yang Liu
Non-small-cell lung cancer has a high mortality rate and poor prognosis. Therefore, novel therapeutic approaches are urgently needed to enhance patient survival rates. In this study, we investigated the effects of miR-21 and EZH2 on the biological behavior of human lung cancer stem cells in vitro. We found increased expression of EZH2 and miR-21 in LCSCs, and miR-21 overexpression increased EZH2 levels in LCSCs. In addition, EZH2 and miR-21 knockdown increased the sensitivity of LCSCs to chemo- and radiation therapy, and exogenous EZH2 expression rescued the effects of anti-miR-21...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156722/whole-exome-sequencing-reveals-novel-mutations-and-epigenetic-regulation-in-hypopharyngeal-carcinoma
#2
Ping Wu, Honglong Wu, Yaoyun Tang, Shi Luo, Xing Fang, Chubo Xie, Jian He, Suping Zhao, Xiaofeng Wang, Jiajia Xu, Xi Chen, Dongfang Li, Huanming Yang, Jian Wang
Hypopharyngeal cancer (HPC) frequently presents at an advanced stage, resulting in poor prognosis. Although combined surgical therapy and chemoradiotherapy have improved the survival for patients with HPC over the past 3 decades, the mortality rate in late-stage diagnosis of HPC is unsatisfactory. In this study, we performed whole-exome sequencing (WES) of 23 hypopharyngeal tumor and paired adjacent normal tissue to identify novel candidate driver genes associated with hypopharyngeal carcinoma. We identified several copy number variants (CNVs) and 15 somatic mutation genes that were associated with hypopharyngeal carcinoma...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155864/supraglottic-squamous-cell-carcinomas-have-distinctive-clinical-features-and-prognosis-based-on-subregion
#3
Weiquan Ding, Tianrun Liu, Jiangang Liang, Tingbao Hu, Shaoyun Cui, Guorong Zou, Weiwei Cai, Ankui Yang
OBJECTIVE: To analyze the clinicopathologic characteristics and prognosis of patients with squamous cell carcinoma localized to different supraglottic subregions. METHODS: Clinicopathologic data were reviewed retrospectively for 111 patients with supraglottic squamous cell carcinoma who were diagnosed between January 1, 1995 and December 31, 2005 and were initially treated with surgery. DNA from human papillomavirus (HPV) 16 and (or /and) HPV 18 were detected in all the 111 supraglottic carcinoma specimens using in situ hybridization...
2017: PloS One
https://www.readbyqxmd.com/read/29155861/pancreatic-exocrine-insufficiency-in-patients-with-chronic-heart-failure-and-its-possible-association-with-appetite-loss
#4
Tingting Xia, Xichen Chai, Jiaqing Shen
BACKGROUND: Appetite loss is one complication of chronic heart failure (CHF), and its association with pancreatic exocrine insufficiency (PEI) is not well investigated in CHF. AIM: We attempted to detect the association between PEI and CHF-induced appetite. METHODS: Patients with CHF were enrolled, and body mass index (BMI), left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) cardiac function grading, B-type natriuretic peptide (BNP), serum albumin, pro-albumin and hemoglobin were evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/29155707/optimized-lc-ms-ms-method-for-the-high-throughput-analysis-of-clinical-samples-of-ivacaftor-its-major-metabolites-and-lumacaftor-in-biological-fluids-of-cystic-fibrosis-patients
#5
Elena K Schneider, Felisa Reyes-Ortega, Jian Li, Tony Velkov
Defects in the cystic fibrosis trans-membrane conductance regulator (CFTR) are the cause of cystic fibrosis (CF), a disease with life-threatening pulmonary manifestations. Ivacaftor (IVA) and ivacaftor-lumacaftor (LUMA) combination are two new breakthrough CF drugs that directly modulate the activity and trafficking of the defective CFTR-protein. However, there is still a dearth of understanding on pharmacokinetic/pharmacodynamic parameters and the pharmacology of ivacaftor and lumacaftor. The HPLC-MS technique for the simultaneous analysis of the concentrations of ivacaftor, hydroxymethyl-ivacaftor, ivacaftor-carboxylate, and lumacaftor in biological fluids in patients receiving standard ivacaftor or ivacaftor-lumacaftor combination therapy has previously been developed by our group and partially validated to FDA standards...
October 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155440/severe-hypoglycemia-caused-by-lenalidomide
#6
Daniel J Przybylski, Ruemu Birhiray, David J Reeves
Lenalidomide is commonly used for multiple myeloma as either induction or maintenance therapy. The agent is associated with a host of adverse effects, but hypoglycemia has only been reported in one phase I trial in patients with solid tumors. We describe a 74-year-old woman who experienced grade 3 hypoglycemia (blood glucose level 35 mg/dL) likely related to lenalidomide. Her medical history was significant for refractory myeloma and type 2 diabetes mellitus. Lenalidomide was started as maintenance therapy following autologous bone marrow transplantation...
November 20, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29155368/urinary-11-dehydro-thromboxane-b2-levels-are-associated-with-vascular-inflammation-and-prognosis-in-atherosclerotic-cardiovascular-disease
#7
Nan Wang, Kimberly C Vendrov, Brian P Simmons, Robert N Schuck, George A Stouffer, Craig R Lee
Cyclooxygenase-derived thromboxane (TxA2) and prostacyclin (PGI2) regulate atherogenesis in preclinical models. However, the relationship between TxA2 and PGI2 biosynthesis, vascular inflammation, and atherosclerotic cardiovascular disease (ASCVD) progression in humans remains unclear. The association between stable urine metabolites of thromboxane (TxA2-M) and prostacyclin (PGI2-M), circulating levels of cellular adhesion molecules (CAMs: E-selectin, P-selectin), chemokines and C-reactive protein, and the incidence of major adverse cardiovascular events (MACE) were evaluated in 120 patients with stable ASCVD on aspirin therapy...
November 16, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29154581/supervisor-employee-power-distance-incompatibility-gender-similarity-and-relationship-conflict-a-test-of-interpersonal-interaction-theory
#8
Katrina A Graham, Scott B Dust, Jonathan C Ziegert
According to interpersonal interaction theory, relational harmony surfaces when two individuals have compatible interaction styles. Building from this theory, we propose that supervisor-employee power distance orientation incompatibility will be related to employees' experience of higher levels of relationship conflict with their supervisors. Additionally, we propose an asymmetrical incongruence effect such that relationship conflict will be highest when supervisors are high in power distance and employees are low in power distance...
November 20, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/29154232/radial-extracorporeal-shockwave-therapy-and-ultrasound-therapy-in-the-treatment-of-tennis-elbow-syndrome
#9
Agnieszka Kubot, Andrzej Grzegorzewski, Marek Synder, Wiesław Szymczak, Piotr Kozłowski
BACKGROUND: Both ultrasound and radial shockwave therapies are used to treat tennis elbow syndrome. The aim of this study was to compare the therapeutic efficacy of both therapies by assessing the reduction in pain intensity and frequency, restoration of mobility, and reduction in the need for pain medication. MATERIAL AND METHODS: The study enrolled 60 people, who were randomly divided into two groups of 30 patients: those treated by radial shockwave therapy and those treated by ultrasound therapy...
October 31, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/29154159/turning-wounds-into-wisdom-posttraumatic-growth-over-the-course-of-two-types-of-trauma-focused-psychotherapy-in-patients-with-ptsd
#10
Mirjam J Nijdam, Christianne A I van der Meer, Mirjam van Zuiden, Pasha Dashtgard, Daniël Medema, Yulan Qing, Paul Zhutovsky, Anne Bakker, Miranda Olff
BACKGROUND: Treatment studies in PTSD patients have mostly focused on adverse psychopathological outcomes whereas positive outcomes have received less attention. Objectives of this study were to investigate posttraumatic growth in response to two different psychotherapies, to examine the relationship between symptom improvement and growth, and to determine if posttraumatic growth predicted treatment response. METHODS: Outpatients diagnosed with PTSD after various types of trauma (n = 116) participated in a randomized controlled trial that compared Brief Eclectic Psychotherapy for PTSD (BEP) and Eye Movement Desensitization and Reprocessing therapy (EMDR)...
November 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29153881/relationship-of-blood-eosinophil-count-to-exacerbations-in-chronic-obstructive-pulmonary-disease
#11
Robert S Zeiger, Trung N Tran, Rebecca K Butler, Michael Schatz, Qiaowu Li, Deepak B Khatry, Ubaldo Martin, Aniket A Kawatkar, Wansu Chen
BACKGROUND: Eosinophilic airway inflammation characterizes a chronic obstructive pulmonary disease (COPD) phenotype that requires more study. OBJECTIVE: To investigate the relationship of blood eosinophil count to exacerbations in COPD. METHODS: Using administrative pharmacy and health care utilization data from 2009 to 2012, we retrospectively identified patients 40 years or older with a COPD diagnosis, postbronchodilator FEV1/forced vital capacity ratio of less than 0...
November 15, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29153636/early-intervention-for-lactate-dehydrogenase-elevation-improves-clinical-outcomes-in-patients-with-the-heartmate-ii-left-ventricular-assist-device-insights-from-the-prevent-study
#12
Thenappan Thenappan, John M Stulak, Richa Agarwal, Simon Maltais, Palak Shah, Peter Eckman, Sitaramesh Emani, Jason N Katz, Igor Gregoric, Mary E Keebler, Nir Uriel, Eric Adler, Joyce Chuang, David J Farrar, Kartik S Sundareswaran, Ranjit John
BACKGROUND: Hemolysis, assessed by elevated serum lactate dehydrogenase (LDH), is strongly associated with HeartMate II pump thrombosis (PT). However, it is unknown whether early intervention for elevated LDH circumvents the risk of serious PT requiring pump exchange. We sought to evaluate the relationship between elevated LDH and clinical outcomes, the effectiveness of early medical intervention, and risk factors for elevated LDH. METHODS: We studied 268 patients in the prospective, multicenter PREVENT study who had 2 or more LDH measurements at ≥30 days post-implant...
October 24, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29153594/the-effectiveness-of-extracorporeal-shockwave-treatment-in-subacromial-impingement-syndrome-and-its-relation-with-acromion-morphology
#13
Esra Circi, Sibel Caglar Okur, Ozge Aksu, Erhan Mumcuoglu, Tolga Tuzuner, Nil Caglar
OBJECTIVE: The aim of this study was to evaluate the effectiveness of the extracorporeal shock wave therapy in the subacromial impingement syndrome and its relationship with the acromion morphology. METHODS: Thirty patients (24 women, 6 men) with subacromial impingement were evaluated. The average age of patients was 53.6 ± 9.8 years (range 39-80). Patients were divided into 3 groups according to the acromion morphology. ESWT 1500 at 0.12 am mL/mm(2) violence was applied once a week for 3 weeks...
November 16, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29153498/hemodynamic-assessment-before-and%C3%A2-after-endovascular-therapy-for-critical%C3%A2-limb-ischemia-and-association-with-clinical-outcomes
#14
Grant W Reed, Laura Young, Imad Bagh, Michael Maier, Mehdi H Shishehbor
OBJECTIVES: This study sought to determine the relationship between change in ankle-brachial index (ABI) and toe-brachial index (TBI) and outcomes following revascularization of critical limb ischemia (CLI). BACKGROUND: An increase in ABI of 0.15 after revascularization for peripheral artery disease with claudication is considered significant. However, the utility of using change in ABI or TBI to predict outcomes in patients with CLI is unproven. METHODS: This was an observational study of 218 patients with Rutherford class V or VI CLI that underwent endovascular therapy...
November 7, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29153225/are-there-clinical-signs-and-symptoms-of-infection-to-indicate-the-presence-of-multidrug-resistant-bacteria-in-venous-ulcers
#15
Silvana de Lima Vieira Dos Santos, Marlene Andrade Martins, Marinésia Aparecida do Prado, José Verdú Soriano, Maria Márcia Bachion
The selection of topical and systemic therapies for the treatment of venous ulcers with signs of infection is challenging and should be accompanied by specific precautionary measures to protect against cross-contamination in the presence of multidrug-resistant microorganisms. However, there are still no clinical indicators for this situation, and confirmation of resistant strains occurs through culture and sensitivity, which can take up to 14 days. During this period, protective measures may no longer be taken, contributing to the spread of these pathogens...
December 2017: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29152998/relationship-between-lung-function-and-inhalation-devices-for-lama-laba-therapy-for-chronic-obstructive-pulmonary-disease
#16
Hideyasu Yamada, Norihito Hida, Hiroaki Satoh, Taisuke Nakaizumi, Hideo Terashima, Nobuyuki Hizawa
No abstract text is available yet for this article.
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29152825/feasibility-study-combining-art-therapy-or-cognitive-remediation-therapy-with-family-based-treatment-for-adolescent-anorexia-nervosa
#17
James Lock, Kathleen Kara Fitzpatrick, William S Agras, Noam Weinbach, Booil Jo
Adolescents with anorexia nervosa who have obsessive-compulsive (OC) features respond poorly to family-based treatment (FBT). This study evaluated the feasibility of combining FBT with either cognitive remediation therapy (CRT) or art therapy (AT) to improve treatment response in this at-risk group. Thirty adolescents with anorexia nervosa and OC features were randomized to 15 sessions of FBT + CRT or AT. Recruitment rate was 1 per month, and treatment attrition was 16.6% with no differences between groups...
November 20, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29152734/access-to-diagnostic-and-therapeutic-facilities-for-psychogenic-nonepileptic-seizures-an-international-survey-by-the-ilae-pnes-task-force-2nd-revision
#18
Coraline Hingray, Wissam El-Hage, Rod Duncan, David Gigineishvili, Kousuke Kanemoto, W Curt LaFrance, Alejandro de Marinis, Ravi Paul, Chrisma Pretorius, José F Téllez Zenteno, Hannah Wiseman, Markus Reuber
OBJECTIVE: Studies from a small number of countries suggest that patients with psychogenic nonepileptic seizures (PNES) have limited access to diagnostic and treatment services. The PNES Task Force of the International League Against Epilepsy (ILAE) carried out 2 surveys to explore the diagnosis and treatment of PNES around the world. METHODS: A short survey (8 questions) was sent to all 114 chapters of the ILAE. A longer survey (36 questions) was completed by healthcare professionals who see patients with seizures...
November 20, 2017: Epilepsia
https://www.readbyqxmd.com/read/29152644/hmga1-participates-in-mhcc97h-cell-proliferation-and-invasion-through-the-ilk-akt-gsk3%C3%AE-signaling-pathway
#19
Li Liu, Shuang Zhang, Lei Hu, Linhua Liu, Wuhua Guo, Jixiang Zhang
Hepatocellular carcinoma (HCC) is one of the major causes of cancer‑related mortality, and the prognosis of HCC patients is unsatisfactory. It is known that the occurrence and development of HCC involves numerous genes, as well as various steps and stages in the pathological process. High mobility group AT‑hook 1 (HMGA1) and integrin‑linked kinase (ILK) may be overexpressed in HCC and may serve important roles in the development of cancer; however, the relationship between HMGA1 and ILK in HCC has not been examined...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29151967/new-clinical-features-and-dosimetric-predictor-identification-for-symptomatic-radiation-pneumonitis-after-tangential-irradiation-in-breast-cancer-patients
#20
Ge Wen, Yu-Ting Tan, Xiao-Wen Lan, Zhi-Chun He, Jiang-Hua Huang, Jun-Tian Shi, Xiao Lin, Xiao-Bo Huang
Background: Tangential irradiation is the most popular postoperative radiotherapy technique for breast cancer. However, irradiation has been related to symptomatic radiation pneumonitis (SRP), which decreases the quality of life of patients. This study investigated the clinical features and dosimetric parameters related to SRP of the ipsilateral lung to identify risk factors for SRP in breast cancer patients after three-dimensional conformal radiation therapy (3D-CRT) with tangential fields. Material and Methods: A total of 515 breast cancer patients were evaluated and divided into two groups: the local-regional irradiation group (259 patients) and the simple local irradiation group (256 patients)...
2017: Journal of Cancer
keyword
keyword
50299
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"