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https://www.readbyqxmd.com/read/29471576/-vegetarian-diets-in-children-an-assessment-from-pediatrics-and-nutrition-science
#1
Mathilde Kersting, Hermann Kalhoff, Michael Melter, Thomas Lücke
In Germany, the "Dietary Schedule for the 1st year of life" and the "Optimised Mixed Diet" for children and adolescents serve as scientifically based and generally applicable dietary concepts throughout the period of growth and development. Vegetarian diets as the lacto-ovo-vegetarian diet (exclusion of meat, fish) and the vegan diet (exclusion of all food groups of animal origin) need to be evaluated for their potential to safely meet the high and specific requirements for growth and development...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471574/-type-2-diabetes-diabetes-in-older-adults-example-for-patient-centered-drug-therapy
#2
Dirk Müller-Wieland
Diabetes in older adults has a high prevalence and is frequently associated with comorbidities of the cardiovascular system, dysfunction of cognition as well as depression and impaired mobility or increased frailty. Furthermore, impaired renal function, heart failure, risk for hypoglycemia and polypharmacy has to be considered in the decision about the diabetes treatment strategy. The goal of blood glucose management is driven by patient relevant issues and patient self-esteem, quality of life defined by the patient, preservation of physical and social mobility rather than potential long-term effects on reduction of cardio- and microvascular events in the future, which is limited by patient-inherent reduced life expectancy of the aged individual...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471569/does-transjugular-intrahepatic-portosystemic-shunt-stent-differentially-improve-survival-in-a-subset-of-cirrhotic-patients
#3
Jonel Trebicka
Does transjugular intrahepatic portosystemic shunt stent (TIPS) improve survival in a subgroup of patients? Yes. TIPS nearly halves portal pressure and increases the effective blood volume. In cases of acute variceal hemorrhage and with a high risk of treatment failure, defined as either hepatic venous pressure gradient higher than 20 mm Hg, Child B with active bleeding at the endoscopy, or Child C with less than 14 points, early or preemptive placement of TIPS (within 72 hours) improves survival. Also, in suitable patients with intractable or refractory ascites, TIPS improves survival if placed early in the course of treatment...
February 2018: Seminars in Liver Disease
https://www.readbyqxmd.com/read/29471555/-pregnancy-after-obesity-and-metabolic-surgery-risks-and-complications
#4
Christine Stroh, Tanja Groten, Eckehardt Schleussner, Thomas Manger
The increasing prevalence of morbid obesity in Germany is associated with an increasing number of metabolic surgical interventions. Short-term surgical and long-term metabolic complications - such as nutrient deficiencies - are the main risks of metabolic surgery and the resulting malabsorption. Obesity, especially morbid obesity, is associated with a high incidence of female infertility. One important cause of female infertility in obese women is the polycystic ovary syndrome, with 6 - 10%. Metabolic surgery significantly increases the fertility of obese women...
February 22, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29471554/-day-surgery-for-endoscopic-inguinal-hernia-repair
#5
Ulrich Steger, Markus Bisping, Jennifer Urban, Thorsten Vowinkel, Aloys Wiesmann, Jonathan Ryll
BACKGROUND: Whereas international guidelines recommend day surgery for endoscopic inguinal hernia repair, this approach is still controversial in Germany. In the light of international guidelines and at the request of patients, we have established total extraperitoneal patch plastic (TEP) surgery in the outpatient setting in our hospital. METHODS: A retrospective analysis of all unilateral TEP procedures carried out between January 2013 and December 2015 in our outpatient surgery, focused on postoperative complications, conversion to admission and rate of recurrence...
February 22, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29471550/phenotype-genotype-correlation-in-children-with-neurofibromatosis-type-1
#6
Christophe Barrea, Sandrine Vaessen, Saskia Bulk, Julie Harvengt, Jean-Paul Misson
Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder with an incidence of ∼1 in 4,000 live births. Neurofibromin, the gene product, is ubiquitously expressed at high levels in the nervous system and functions as a tumor suppressor. Haploinsufficiency of neurofibromin through mutation leads to an increased risk of developing benign and malignant tumors in affected individuals. Although NF1 has complete penetrance, it displays considerable inter- and intrafamilial variability in phenotypic expression which poses disease prediction and management problems...
February 22, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29471546/longitudinal-analyses-of-blood-transcriptome-during-conversion-to-psychosis
#7
Boris Chaumette, Oussama Kebir, Juliette Pouch, Bertrand Ducos, Fekrije Selimi, Raphael Gaillard, Marie-Odile Krebs
The biological processes associated with the onset of schizophrenia remain largely unknown. Current hypotheses favor gene × environment interactions as supported by our recent report about DNA methylation changes during the onset of psychosis. Here, we conducted the first longitudinal transcriptomic analysis of blood samples from 31 at-risk individuals who later converted to psychosis and 63 at-risk individuals who did not. Individuals were followed for a maximum of 1 year. Blood samples were collected at baseline and at the end of follow-up and individuals served as their own controls...
February 17, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29471491/farming-characteristics-and-self-reported-health-outcomes-of-irish-farmers
#8
D van Doorn, N Richardson, A Storey, A Osborne, C Cunningham, C Blake, J McNamara
Background: Irish farmers represent a 'high-risk' group for non-communicable diseases, which, arguably, pose a greater occupational health challenge for farmers. To date, there has been little exploration of the farming characteristics associated with farmers' poor health outcomes. Aims: To examine the relationship between farming and male farmers' self-reported health outcomes and to compare the study findings to national health studies to explore which factors specifically are associated with Irish farmers' poorer health outcomes relative to the general population...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471473/bidirectional-gpr119-agonism-requires-peptide-yy-and-glucose-for-activity-in-mouse-and-human-colon-mucosa
#9
Iain R Tough, Sarah Forbes, Herbert Herzog, Robert M Jones, Thue W Schwartz, Helen M Cox
The lipid sensor GPR119 is highly expressed by enteroendocrine L-cells and pancreatic β-cells that release the hormones, PYY and GLP-1, and insulin, respectively. Endogenous oleoylethanolamide (OEA) and the dietary metabolite, 2-monoacylglycerol (2-OG) can each activate GPR119. Here we compared mucosal responses to selective, synthetic GPR119 agonists (AR440006, AR231453) and the lipids, OEA, 2-OG and N-oleoyldopamine (OLDA) monitoring epithelial ion transport as a read-out for L-cell activity in native mouse and human gastrointestinal (GI) mucosae...
February 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29471410/risk-factors-associated-with-sustaining-a-sport-related-concussion-an-initial-synthesis-study-of-12-320-student-athletes
#10
Benjamin L Brett, Andrew W Kuhn, Aaron M Yengo-Kahn, Gary S Solomon, Scott L Zuckerman
Objective: The empirical identification of risk factors associated with sport-related concussion (SRC) may improve the management of student-athletes. The current study attempted to identify and quantify bio-cognitive risk factors associated with sustaining a SRC. Methods: Cross-sectional ambispective study; level of evidence, 3. Neurocognitive testing of 12,320 middle school, high school and collegiate athletes was completed at preseason baseline and post-SRC. Univariate and multivariable logistic regressions were used to determine which pre-injury variables accurately predicted the occurrence of SRC...
February 17, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29471391/comparative-efficacy-of-enrofloxacin-to-that-of-tulathromycin-for-the-control-of-bovine-respiratory-disease-and-prevalence-of-antimicrobial-resistance-in-mannheimia-haemolytica-in-calves-at-high-risk-of-developing-bovine-respiratory-disease
#11
S Crosby, B Credille, S Giguère, R Berghaus
Bovine respiratory disease (BRD) is the most common cause of morbidity and mortality in North American beef cattle. Mannheimia haemolytica (Mh) is the bacterial pathogen most often isolated from cattle with BRD and the prevalence of antimicrobial resistance (AMR) in this organism has increased in recent years. Antimicrobials are commonly used to prevent BRD in cattle at high-risk of developing BRD, however, recent work would suggest that this practice might be one factor contributing to the increased prevalence of AMR in Mh...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471382/gendered-safety-and-health-risks-in-the-construction-trades
#12
Hannah M Curtis, Hendrika Meischke, Bert Stover, Nancy J Simcox, Noah S Seixas
Objectives: Despite women's increased representation in the overall workforce, construction remains a male-dominated industry. Prior studies have noted that the hazardous workplace environment combined with a culture that can be discriminatory and openly hostile can threaten women workers' health and safety. However, little information exists about the current physical and psychosocial hazards at work affecting tradeswomen. Methods: We examined differences in workplace exposure between women and men, and the association of these exposures with self-reported stress and work injury, in order to highlight how gendered conditions of work negatively affect tradeswomen's health...
February 17, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29471355/closing-the-loop-with-an-enhanced-referral-management-system
#13
Harley Ramelson, Amanda Nederlof, Sam Karmiy, Pamela Neri, David Kiernan, Rajlakshmi Krishnamurthy, Adrienne Allen, David W Bates
Objective: To evaluate the impact of a referral manager tool on primary care practices. Materials and Methods: We evaluated a referral manager module in a locally developed electronic health record (EHR) that was enhanced to improve the referral management process in primary care practices. Baseline (n = 61) and follow-up (n = 35) provider and staff surveys focused on the ease of performing various steps in the referral process, confidence in completing those steps, and user satisfaction...
February 17, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29471348/sexual-dimorphism-of-resting-state-network-connectivity-in-healthy-ageing
#14
Sharna D Jamadar, Francesco Sforazzini, Parnesh Raniga, Nicholas J Ferris, Bryan Paton, Michael J Bailey, Amy Brodtmann, Paul A Yates, Geoffrey A Donnan, Stephanie A Ward, Robyn L Woods, Elsdon Storey, John J McNeil, Gary F Egan
Objectives: The onset of many illnesses is confounded with age and sex. Increasing age is a risk factor for the development of many illnesses, and sexual dimorphism influences brain anatomy, function, and cognition. Here, we examine frequency-specific connectivity in resting-state networks in a large sample (n = 406) of healthy aged adults. Method: We quantify frequency-specific connectivity in three resting-state networks known to be implicated in age-related decline: the default mode, dorsal attention, and salience networks, using multiband functional magnetic resonance imaging...
February 17, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29471323/what-s-to-be-done-about-laboratory-quality-process-indicators-laboratory-stewardship-the-outcomes-problem-risk-assessment-and-economic-value-responding-to-contemporary-global-challenges
#15
Frederick A Meier, Tony C Badrick, Kenneth A Sikaris
Objectives: For 50 years, structure, process, and outcomes measures have assessed health care quality. For clinical laboratories, structural quality has generally been assessed by inspection. For assessing process, quality indicators (QIs), statistical monitors of steps in the clinical laboratory total testing, have proliferated across the globe. Connections between structural and process laboratory measures and patient outcomes, however, have rarely been demonstrated. Methods: To inform further development of clinical laboratory quality systems, we conducted a selective but worldwide review of publications on clinical laboratory quality assessment...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29471301/repeated-bioimpedance-measurements-predict-prognosis-of-peritoneal-dialysis-patients
#16
Jwa-Kyung Kim, Young Rim Song, Hyung Seok Lee, Hyung Jik Kim, Sung Gyun Kim
BACKGROUND: Fluid overload is a major risk factor for mortality in patients undergoing peritoneal dialysis (PD). However, few studies have investigated the effect of chronic exposure to sustained fluid overload on long-term outcomes. METHOD: A total of 284 prevalent PD patients were included in this prospective study. Repeated multifrequency body composition analysis was performed 12 months apart, and 1-year cumulative chronic fluid overload were used to predict all-cause mortality and the risk for transfer to hemodialysis (HD) during the ensuing 15...
February 22, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29471300/yttrium-90-ibritumomab-tiuxetan-zevalin%C3%A2-radioimmunotherapy-after-cytoreduction-with-eshap-chemotherapy-in-patients-with-relapsed-follicular-non-hodgkin-lymphoma-final-results-of-a-phase-ii-study
#17
Soham D Puvvada, José M Guillén-Rodríguez, Jessica Yan, Lora Inclán, Kara Heard, Xavier I Rivera, Faiz Anwer, Daruka Mahadevan, Jonathan H Schatz, Daniel O Persky
BACKGROUND: Radioimmunotherapy (RIT) is effective in treating relapsed/refractory follicular lymphoma (FL), with durable remissions in first-line consolidation. We hypothesized that RIT with ibritumomab tiuxetan (Zevalin®) would result in durable remissions by eliminating minimal residual disease after cytoreduction. METHODS: Patients with FL received 2 cycles of ESHAP (etoposide, methylprednisolone, cytarabine, cisplatin) every 28 days, followed by Zevalin 4-6 weeks later if there was no disease progression and bone marrow biopsy showed < 25% involvement...
February 22, 2018: Oncology
https://www.readbyqxmd.com/read/29471289/single-nucleotide-polymorphism-facilitated-down-regulation-of-the-cohesin-stromal-antigen-1-implications-for-colorectal-cancer-racial-disparities
#18
Somenath Datta, Richard M Sherva, Mart De La Cruz, Michelle T Long, Priya Roy, Vadim Backman, Sanjib Chowdhury, Hemant K Roy
The biological underpinnings for racial disparities in colorectal cancer (CRC) incidence remain to be elucidated. We have previously reported that the cohesin SA-1 down-regulation is an early event in colon carcinogenesis which is dramatically accentuated in African-Americans. In order to investigate the mechanism, we evaluated single nucleotide polymorphisms (SNPs) for association with SA-1-related outcomes followed by gene editing of candidate SNP. We observed that rs34149860 SNP was significantly associated with a lower colonic mucosal SA-1 expression and evaluation of public databases showed striking racial discordance...
February 19, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29471191/peak-knee-biomechanics-and-limb-symmetry-following-unilateral-anterior-cruciate-ligament-reconstruction-associations-of-walking-gait-and-jump-landing-outcomes
#19
Steven J Pfeiffer, J Troy Blackburn, Brittney Luc-Harkey, Matthew S Harkey, Laura E Stanley, Barnett Frank, Darin Padua, Stephen W Marshall, Jeffrey T Spang, Brian Pietrosimone
BACKGROUND: Aberrant walking-gait and jump-landing biomechanics may influence the development of post-traumatic osteoarthritis and increase the risk of a second anterior cruciate ligament injury, respectively. It remains unknown if individuals who demonstrate altered walking-gait biomechanics demonstrate similar altered biomechanics during jump-landing. Our aim was to determine associations in peak knee biomechanics and limb-symmetry indices between walking-gait and jump-landing tasks in individuals with a unilateral anterior cruciate ligament reconstruction...
January 31, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29471188/developing-cross-validating-and-applying-regression-models-to-predict-the-concentrations-of-faecal-indicator-organisms-in-coastal-waters-under-different-environmental-scenarios
#20
Robson V de Souza, Carlos J A Campos, Luis H P Garbossa, Walter Q Seiffert
This study developed, cross-validated and applied a regression-based model to predict concentrations of faecal indicator organisms (FIOs) under different environmental conditions in the North and South bays of Santa Catarina, South of Brazil. The model was developed using a database of FIO concentrations in seawater sampled at 50 sites and the validation was performed using a different database by comparing 288 pairs of measured and modelled results for 15 sites. The index of agreement between the model outputs and the FIO concentrations measured during the validation period was 66%; the mean average error was 0...
February 19, 2018: Science of the Total Environment
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