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Hypoxia-ischemia

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https://www.readbyqxmd.com/read/28632497/dha-reduces-oxidative-stress-following-hypoxia-ischemia-in-newborn-piglets-a-study-of-lipid-peroxidation-products-in-urine-and-plasma
#1
Marianne Ullestad Huun, Håvard T Garberg, Javier Escobar, Consuelo Chafer, Maximo Vento, Ingar M Holme, Ola Didrik Saugstad, Rønnaug Solberg
BACKGROUND: Lipid peroxidation mediated by reactive oxygen species is a major contributor to oxidative stress. Docosahexaenoic acid (DHA) has anti-oxidant and neuroprotective properties. Our objective was to assess how oxidative stress measured by lipid peroxidation was modified by DHA in a newborn piglet model of hypoxia-ischemia (HI). METHODS: Fifty-five piglets were randomized to (i) hypoxia, (ii) DHA, (iii) hypothermia, (iv) hypothermia+DHA or (v) sham. All groups but sham were subjected to hypoxia by breathing 8% O2...
June 20, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28616019/hypoxia-inducible-factor-1-alpha-stabilization-for-regenerative-therapy-in-traumatic-brain-injury
#2
REVIEW
Mushfiquddin Khan, Hamza Khan, Inderjit Singh, Avtar K Singh
Mild traumatic brain injury (TBI), also called concussion, initiates sequelae leading to motor deficits, cognitive impairments and subtly compromised neurobehaviors. While the acute phase of TBI is associated with neuroinflammation and nitroxidative burst, the chronic phase shows a lack of stimulation of the neurorepair process and regeneration. The deficiency of nitric oxide (NO), the consequent disturbed NO metabolome, and imbalanced mechanisms of S-nitrosylation are implicated in blocking the mechanisms of neurorepair processes and functional recovery in the both phases...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28599922/vitamin-d-improves-functional-outcomes-in-neonatal-hypoxic-ischemic-male-rats-treated-with-n-acetylcysteine-and-hypothermia
#3
Danielle W Lowe, Jamie L Fraser, Laura Grace Rollins, Jessica Bentzley, Xingju Nie, Renee Martin, Inderjit Singh, Dorothea Jenkins
Hypothermia treatment neuroprotects approximately 50% of neonates who present with moderate to severe hypoxic ischemic encephalopathy (HIE). N-acetylcysteine (NAC), a potent antioxidant, is neuroprotective in combination with hypothermia in neonatal hypoxia-ischemia (HI) female rats, but less protective in males. Vitamin D is a neurosteroid, which may provide immunomodulation and improve outcomes for both sexes. We investigated the efficacy of this combination of drugs with hypothermia after severe HI, as well as potential mechanisms of vitamin D effects in the transition to chronic inflammation...
June 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28595534/a-review-of-levetiracetam-in-neonates
#4
Amit Agrawal, Anita Banergee
BACKGROUND: Neonatal seizures are the most common clinical manifestation of central nervous system (CNS) dysfunction and are associated with various neurological sequelae. There are currently no evidence-based guidelines for the management of neonatal seizures and currently used drugs such as phenobarbital, and phenytoin have limited efficacy and potential toxicities. Newer second line anticonvulsant, levetiracetam, has been used in refractory neonatal seizures despite limited data and off-label use...
June 6, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28576310/the-paracrine-effect-of-cobalt-chloride-on-bmscs-during-cognitive-function-rescue-in-the-hibd-rat
#5
Ying Dai, Wendi Li, Min Zhong, Jie Chen, Qian Cheng, Youxue Liu, Tingyu Li
Hypoxia-ischemia (HI)-induced perinatal encephalopathy frequently causes chronic neurological morbidities and acute mortality. Bone mesenchymal stem cell (BMSC) transplantation could potentially promote functional and anatomical recovery of ischemic tissue. In vitro hypoxic preconditioning is an effective strategy to improve the survival of BMSCs in ischemic tissue. In this study, cobalt chloride (CoCl2) preconditioned medium from BMSC cultures was injected into the left lateral ventricle of HI rats using a micro-osmotic pump at a flow rate 1...
May 30, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28564654/high-dose-cannabidiol-induced-hypotension-after-global-hypoxia-ischemia-in-piglets
#6
Håvard T Garberg, Rønnaug Solberg, Jon Barlinn, Jose Martinez-Orgado, Else-Marit Løberg, Ola Didrik Saugstad
BACKGROUND: Cannabidiol (CBD) is considered a promising neuroprotectant after perinatal hypoxia-ischemia (HI). We have previously studied the effects of CBD 1 mg/kg in the early phase after global HI in piglets. In contrast to prior studies, we found no evidence of neuroprotection and hypothesized that higher doses might be required to demonstrate efficacy in this animal model. OBJECTIVE: To assess the safety and potential neuroprotective effects of high-dose CBD...
June 1, 2017: Neonatology
https://www.readbyqxmd.com/read/28561815/effects-of-therapeutic-hypothermia-on-white-matter-injury-from-murine-neonatal-hypoxia-ischemia
#7
Elliot Koo, R Ann Sheldon, Byong Sop Lee, Zinaida S Vexler, Donna M Ferriero
BackgroundTherapeutic hypothermia (TH) is the standard of care for neonates with hypoxic-ischemic encephalopathy, but it is not fully protective in the clinical setting. Hypoxia-ischemia (HI) may cause white matter injury (WMI), leading to neurological and cognitive dysfunction.MethodsP9 mice were subjected to HI as previously described. Pups underwent 3.5 h of systemic hypothermia or normothermia. Cresyl violet and Perl's iron staining for histopathological scoring of brain sections was completed blindly on all brains...
May 31, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28548285/neonatal-hypoxia-ischemia-in-rat-increases-doublecortin-concentration-in-the-cerebrospinal-fluid
#8
Catherine Brégère, Urs Fisch, Martin H Sailer, Wolfgang S Lieb, Laurie Chicha, Fabienne Goepfert, Thomas Kremer, Raphael Guzman
Doublecortin (DCX) is a microtubule-associated protein widely used as an indicator of neurogenesis in immunohistochemical analyses of the postmortem adult brain. A recent study reported that DCX can be quantified in the cerebrospinal fluid (CSF) from healthy rats between postnatal day 0 (P0) and P30. However, it is currently unclear whether the concentration of DCX in the CSF (CSF-DCX) may represent a measure of endogenous neurogenesis. To address this question, the present study examined the impact of a neonatal hypoxic-ischemic (HI) brain injury, known to induce neurogenesis, on CSF-DCX...
May 26, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28527815/neuroimaging-and-neuropathological-characteristics-of-cerebellar-injury-in-extremely-low-birth-weight-infants
#9
Mayumi Matsufuji, Nozomi Sano, Hisashi Tsuru, Sachio Takashima
OBJECTIVE: To determine the morphological characteristics and pathogenic factors of cerebellar injury in extremely low birth weight infants (ELBWI). SUBJECTS AND METHODS: Neuroimaging examination was performed on 17 eligible surviving ELBWI. Their MR images were assessed and classified its pattern of cerebellar injuries. Brain pathology was examined on 15 patients, who isolated this neuroimaging subjects. The trend of brain pathologies was revealed. RESULTS: Four types of morphological pattern were recognized: (i) the absence of major portions in the cerebellum (6/17 cases); (ii) focal cerebellar tissue loss (2/17); (iii) unilateral cerebellar atrophy/hypoplasia (3/17); (iv) small cerebellum with entrapped fourth ventricle (6/17)...
May 17, 2017: Brain & Development
https://www.readbyqxmd.com/read/28523564/prenatal-and-early-postnatal-environmental-enrichment-reduce-acute-cell-death-and-prevent-neurodevelopment-and-memory-impairments-in-rats-submitted-to-neonatal-hypoxia-ischemia
#10
L E Durán-Carabali, D M Arcego, F K Odorcyk, L Reichert, J L Cordeiro, E F Sanches, L D Freitas, C Dalmaz, A Pagnussat, C A Netto
Environmental enrichment (EE) is an experimental strategy to attenuate the negative effects of different neurological conditions including neonatal hypoxia ischemia encephalopathy (HIE). The aim of the present study was to investigate the influence of prenatal and early postnatal EE in animals submitted to neonatal HIE model at postnatal day (PND) 3. Wistar rats were housed in EE or standard conditions (SC) during pregnancy and lactation periods. Pups of both sexes were assigned to one of four experimental groups, considering the early environmental conditions and the injury: SC-Sham, SC-HIE, EE-sham, and EE-HIE...
May 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28512386/oxidative-stress-biomarkers-establishment-of-reference-values-for-isoprostanes-aopp-and-npbi-in-cord-blood
#11
Mariangela Longini, Elisa Belvisi, Fabrizio Proietti, Francesco Bazzini, Giuseppe Buonocore, Serafina Perrone
Oxidative stress (OS) is a common pathogenic factor involved in the onset of several diseases in humans, from immunologic disorders to malignancy, being a serious public health problem. In perinatal period, OS has been associated with adverse outcome of pregnancy and neonatal diseases. Dangerous effects of OS are mediated by increased production of free radicals (FRs) following various mechanisms, such as hypoxia, ischemia reperfusion, hyperoxia, inflammation, mitochondrial dysfunction, Fenton chemistry, and prostaglandin metabolism...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28508995/l-carnitine-and-acetyl-l-carnitine-roles-and-neuroprotection-in-developing-brain
#12
Gustavo C Ferreira, Mary C McKenna
L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. Treatment with L-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism. In recent years there has been considerable interest in the therapeutic potential of L-carnitine and its acetylated derivative acetyl-L-carnitine (ALCAR) for neuroprotection in a number of disorders including hypoxia-ischemia, traumatic brain injury, Alzheimer's disease and in conditions leading to central or peripheral nervous system injury...
June 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28502584/up-regulation-of-mir-325-3p-suppresses-pineal-aralkylamine-n-acetyltransferase-aanat-after-neonatal-hypoxia-ischemia-brain-injury-in-rats
#13
Yuanyuan Yang, Bin Sun, Jian Huang, Lixiao Xu, Jian Pan, Chen Fang, Mei Li, Gen Li, Yanfang Tao, Xiaofeng Yang, Ying Wu, Po Miao, Ying Wang, Hong Li, Jing Ren, Meiqin Zhan, Yiping Fang, Xing Feng, Xin Ding
Survivors of hypoxic-ischemic brain damage (HIBD), besides impairment of psychomotor development, often develop circadian rhythm disorders, although the underlying mechanisms are largely unknown. Here, we first verified that mRNA and protein expression of pineal aralkylamine N-acetyltransferase (Aanat), a key regulator for melatonin (MT) synthesis, along with MT, were severely impaired after HIBD. In addition, we demonstrated that neonatal HIBD disrupted the circadian rhythmicity of locomotor activities in juvenile rats...
May 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28499802/ampk-activates-foxo3a-and-promotes-neuronal-apoptosis-in-the-developing-rat-brain-during-the-early-phase-after-hypoxia-ischemia
#14
Deyuan Li, Lili Luo, Min Xu, Jinlin Wu, Lina Chen, Jinhui Li, Zhongqiang Liu, Guoyan Lu, Yang Wang, Lina Qiao
AMP-activated protein kinase (AMPK) is a key metabolic and stress sensor/effector. Few investigations have been performed to study the role of AMPK in developing rat brain with hypoxia-ischemia (HI). Forkhead transcriptional factor (FOXO3a) has been revealed to be a critical effector of AMPK-mediated celluar apoptosis. However, it is not clear whether AMPK/FOXO3a pathway is involved in neuronal apoptosis in the developing rat brain after HI. In this study, we generated hypoxia-ischemia brain damage (HIBD) model using postnatal day 7 rats...
May 10, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28495306/long-term-effects-of-enriched-environment-following-neonatal-hypoxia-ischemia-on-behavior-bdnf-and-synaptophysin-levels-in-rat-hippocampus-effect-of-combined-treatment-with-g-csf
#15
Myrsini Griva, Rosa Lagoudaki, Olga Touloumi, Evangelia Nousiopoulou, Filippos Karalis, Thomas Georgiou, Georgia Kokaraki, Constantina Simeonidou, Despina A Tata, Evangelia Spandou
Increasing evidence shows that exposure to an enriched environment (EE) is neuroprotective in adult and neonatal animal models of brain ischemia. However, the mechanisms underlying this effect remain unclear. The aim of the current study was to investigate whether post-weaning EE would be effective in preventing functional deficits and brain damage by affecting markers of synaptic plasticity in a neonatal rat model of hypoxia-ischemia (HI). We also examined the possibility that granulocyte-colony stimulating factor (G-CSF), a growth factor with known neuroprotective effects in a variety of experimental brain injury models, combined with EE stimulation could enhance the potential beneficial effect of EE...
May 8, 2017: Brain Research
https://www.readbyqxmd.com/read/28492551/haploinsufficiency-in-the-mitochondrial-protein-chchd4-reduces-brain-injury-in-a-mouse-model-of-neonatal-hypoxia-ischemia
#16
Yanyan Sun, Tao Li, Cuicui Xie, Yiran Xu, Kai Zhou, Juan Rodriguez, Wei Han, Xiaoyang Wang, Guido Kroemer, Nazanine Modjtahedi, Klas Blomgren, Changlian Zhu
Mitochondria contribute to neonatal hypoxic-ischemic brain injury by releasing potentially toxic proteins into the cytosol. CHCHD4 is a mitochondrial intermembrane space protein that plays a major role in the import of intermembrane proteins and physically interacts with apoptosis-inducing factor (AIF). The purpose of this study was to investigate the impact of CHCHD4 haploinsufficiency on mitochondrial function and brain injury after cerebral hypoxia-ischemia (HI) in neonatal mice. CHCHD4(+/-) and wild-type littermate mouse pups were subjected to unilateral cerebral HI on postnatal day 9...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28487967/comparative-analysis-of-the-beneficial-effects-of-treadmill-training-and-electroacupuncture-in-a-rat-model-of-neonatal-hypoxia-ischemia
#17
Ha Neui Kim, Malk Eun Pak, Myung Jun Shin, Soo Yeon Kim, Yong Beom Shin, Young Ju Yun, Hwa Kyoung Shin, Byung Tae Choi
In the present study, we investigated whether treadmill training and electroacupuncture (EA) have autonomous or synergistic beneficial effects on deficits caused by neonatal hypoxia‑ischemia in Sprague-Dawley rats. For this purpose, rats subjected to hypoxia-ischemia underwent treadmill training and EA stimulation from 4 to 8 weeks of age. Conventional EA (CEA) and scalp EA (SEA) were delivered by electrical stimulation (2 Hz, 1 mA) at traditional acupoints and at the scalp to the primary motor area, respectively...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28487658/early-changes-in-glutamate-metabolism-and-perfusion-in-basal-ganglia-following-hypoxia-ischemia-in-neonatal-piglets-a-multi-sequence-3-0t-mr-study
#18
Yu-Xue Dang, Kai-Ning Shi, Xiao-Ming Wang
The excitotoxicity of glutamate metabolism as well as hemodynamic disorders of the brain are both risk factors for neonatal hypoxic-ischemic brain damage (HIBD). In the present study, changes in glutamate metabolism in the basal ganglia were detected by proton magnetic resonance spectroscopy ((1)H-MRS) at 0-6, 8-12, 24-30, and 48-60 h after the induction of hypoxia-ischemia (HI) in newborn piglets. Meanwhile, correlation analysis was performed by combining the microcirculatory perfusion informations acquired by intravoxel incoherent motion (IVIM) scan to explore their possible interaction mechanism...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28469656/neuroprotective-effects-of-autophagy-inhibition-on-hippocampal-glutamate-receptor-subunits-after-hypoxia-ischemia-induced-brain-damage-in-newborn-rats
#19
Li-Xiao Xu, Xiao-Juan Tang, Yuan-Yuan Yang, Mei Li, Mei-Fang Jin, Po Miao, Xin Ding, Ying Wang, Yan-Hong Li, Bin Sun, Xing Feng
Autophagy has been suggested to participate in the pathology of hypoxic-ischemic brain damage (HIBD). However, its regulatory role in HIBD remains unclear and was thus examined here using a rat model. To induce HIBD, the left common carotid artery was ligated in neonatal rats, and the rats were subjected to hypoxia for 2 hours. Some of these rats were intraperitoneally pretreated with the autophagy inhibitor 3-methyladenine (10 mM in 10 μL) or the autophagy stimulator rapamycin (1 g/kg) 1 hour before artery ligation...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28448965/neuroprotective-treatments-after-perinatal-hypoxic-ischemic-brain-injury-evaluated-with-magnetic-resonance-spectroscopy
#20
Hester Rijkje Berger, Eva Brekke, Marius Widerøe, Tora Sund Morken
Perinatal hypoxic-ischemic brain injury is a major health problem. Adjuvant treatments that improve the neuroprotective effect of the current treatment, therapeutic hypothermia, are urgently needed. The growing knowledge about the complex pathophysiology of hypoxia-ischemia (HI) has led to the discovery of several important targets for neuroprotection. Early interventions should focus on the preservation of energy metabolism, the reduction of glutamate excitotoxicity and oxidative stress, the maintenance of calcium homeostasis, and the prevention of apoptosis...
April 28, 2017: Developmental Neuroscience
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