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https://www.readbyqxmd.com/read/29331618/efficacy-and-safety-of-sublingual-immunotherapy-with-dermatophagoides-farinae-drops-in-pre-school-and-school-age-children-with-allergic-rhinitis
#1
L-X Tang, X-J Yang, P-P Wang, W-T Ge, J Zhang, Y-L Guo, J Lu, J Tai, Y-M Zhang, X Ni
BACKGROUND: The safety and efficacy of sublingual immunotherapy (SLIT) have been confirmed by many studies. However, in China, the research on efficacy and safety in young and older children with allergic rhinitis (AR) is still rare. OBJECTIVE: The aim of this retrospective study is to evaluate the efficacy and safety of SLIT with Dermatophagoides farinae drops in pre-school and school-age children with AR. METHODS: A total of 282 subjects aged 2-13 years with AR received a two-year course of sublingual immunotherapy along with pharmacotherapy...
January 10, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29331054/artist-a-fully-automated-artifact-rejection-algorithm-for-single-pulse-tms-eeg-data
#2
Wei Wu, Corey J Keller, Nigel C Rogasch, Parker Longwell, Emmanuel Shpigel, Camarin E Rolle, Amit Etkin
Concurrent single-pulse TMS-EEG (spTMS-EEG) is an emerging noninvasive tool for probing causal brain dynamics in humans. However, in addition to the common artifacts in standard EEG data, spTMS-EEG data suffer from enormous stimulation-induced artifacts, posing significant challenges to the extraction of neural information. Typically, neural signals are analyzed after a manual time-intensive and often subjective process of artifact rejection. Here we describe a fully automated algorithm for spTMS-EEG artifact rejection...
January 13, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29328345/oxidative-radical-divergent-si-incorporation-facile-access-to-si-containing-heterocycles
#3
Yuan Yang, Ren-Jie Song, Yang Li, Xuan-Hui Ouyang, Jin-Heng Li, De-Liang He
A copper-catalyzed oxidative radical strategy to avoid the use of the highly expensive noble metal/ligand catalytic systems is described, which allows selective activation of dual chemical bonds around the Si-atom center relying on the nature of alkylsilanes. While for tertiary silanes selective functionalization of Si-H/silyl C(sp3)-H bonds in intermolecular oxidative annulation cascades with N-(2-(ethynyl)aryl)acrylamides toward silino[3,4-c]quinolin-5(3H)-ones, when using secondary silanes and HSi(TMS)3, dual Si-H bonds or Si-H/Si-Si bonds are selectively cleaved leading to 4H-silolo[3,4-c]quinolin-4-ones...
January 12, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29326293/physiological-effects-of-subthalamic-nucleus-deep-brain-stimulation-surgery-in-cervical-dystonia
#4
Aparna Wagle Shukla, Jill L Ostrem, David E Vaillancourt, Robert Chen, Kelly D Foote, Michael S Okun
BACKGROUND: Subthalamic nucleus deep brain stimulation (STN DBS) surgery is clinically effective for treatment of cervical dystonia; however, the underlying physiology has not been examined. We used transcranial magnetic stimulation (TMS) to examine the effects of STN DBS on sensorimotor integration, sensorimotor plasticity and motor cortex excitability, which are identified as the key pathophysiological features underlying dystonia. METHODS: TMS paradigms of short latency afferent inhibition (SAI) and long latency afferent inhibition (LAI) were used to examine the sensorimotor integration...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29326022/the-effects-of-repetitive-transcranial-magnetic-stimulation-on-eating-behaviors-and-body-weight-in-obesity-a-randomized-controlled-study
#5
Se-Hong Kim, Ju-Hye Chung, Tae-Hong Kim, Seong Hoon Lim, Youngkook Kim, Yun-Ah Lee, Sang-Wook Song
BACKGROUND: Although some studies have reported significant reductions in food cravings following repetitive transcranial magnetic stimulation (rTMS), none have examined changes in body weight. OBJECTIVE: We conducted 2-week randomized, sham-controlled, single-blind, parallel-group trial to examine the effect of rTMS on body weight in obese patients. METHODS: Sixty obese patients (body mass index [BMI] ≥25 kg/m2) aged between 18 and 65 years were recruited...
December 1, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29325145/anxiety-dependent-modulation-of-motor-responses-to-pain-expectancy
#6
Carlotta Fossataro, Giulia Bucchioni, Federico D'Agata, Valentina Bruno, Rosalba Morese, Pierre Krystkowiak, Francesca Garbarini
The relationship between pain expectancy and motor system plays a crucial role in the human defensive system. Here, we took advantage of the inhibitory modulation of the motor pathway to the muscle of the hand receiving painful stimuli, by recording motor-evoked potentials (MEPs) to Transcranial Magnetic Stimulation (TMS). We employed a classical conditioning paradigm in which neutral (visual and auditory) stimuli were conditioned by pairing either painful or not-painful stimuli (electric shocks) in separated groups...
January 8, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29322565/on-the-variable-reactivity-of-phosphine-functionalized-ge9-clusters-zintl-cluster-substituted-phosphines-or-phosphine-substituted-zintl-clusters
#7
Thomas Friedrich Fässler, Felix Geitner, Christoph Wallach
The reaction of [(Ge9{Si(TMS)3}2PtBu2)]- with NHCMesCuCl yields [(Ge9{Si(TMS)3}2)(tBu2P)]Cu(NHCMes) (1), which is a new derivative of the recently reported monomeric zwitterionic tetrel cluster compounds [(Ge9{Si(TMS)3}2)(tBu2P)]M(NHCDipp) (M: Cu, Ag, Au). By contrast, the reaction of the same anion [(Ge9{Si(TMS)3}2PtBu2)]- with the more labile copper phosphine complex Cy3PCuCl leads to the formation of [Ge9{Si(TMS)3}2{(tBu)2PCu}2Ge9{Si(TMS)3}2] (2) which is a neutral dimeric twofold-bridged [Ge9] cluster compound, with the exo-bonded phosphine substituent being involved in the cluster bridging...
January 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29322201/characterization-of-corticospinal-activation-of-finger-motor-neurons-during-precision-and-power-grip-in-humans
#8
Christian Svane, Christian Riis Forman, Jens Bo Nielsen, Svend Sparre Geertsen
Direct and indirect corticospinal pathways to finger muscles may play a different role in control of the upper extremity. We used transcranial magnetic stimulation (TMS) and coherence analysis to characterize the corticospinal drive to the first dorsal interosseous (FDI) and abductor pollicis brevis (APB) when active during a precision and power grip task. In experiment 1, single motor units were recorded during precision grip and power grip in 20 adults (25.2 ± 7.1 years). Post-stimulus time histograms (PSTH) were obtained following TMS...
January 10, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29320814/genotypic-identification-of-cystoisospora-in-immunocompromised-patients-using-tm-variation-analysis
#9
Maha M A Basyoni, Hany Ahmed Fouad Elghobary
Cystoisospora is responsible for morbidity in immunocompromised patients. PCR is sensitive for diagnosing Cystoisospora; however, it needs reevaluation for differential molecular diagnosis of cystoisosporiasis. We aimed at evaluating melting curve analysis (MCA) after real-time PCR (qPCR) in diagnosis and genotyping of Cystoisospora as an alternative to conventional PCR. We included 293 diarrheic stool samples of patients attending the Department of Clinical Oncology and Nuclear Medicine of Cairo University Hospitals, Egypt...
December 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29319216/cobalt-catalyzed-coupling-of-benzoic-acid-c-h-bonds-with-alkynes-styrenes-and-1-3-dienes
#10
Tung Thanh Nguyen, Liene Grigorjeva, Olafs Daugulis
A method for cobalt-catalyzed, carboxylate-directed functionalization of arene C-H bonds is reported. Alkynes, styrenes, and 1,3-dienes can be coupled with benzoic acids to provide cyclic products in good yields. The reactions proceed in the presence of a cobalt(II) hexafluoroacetylacetonate catalyst, (TMS)2 NH base, Ce(SO4 )2 cooxidant, and oxygen oxidant.
January 10, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29317325/motor-cortex-compensates-for-lack-of-sensory-and-motor-experience-during-auditory-speech-perception
#11
Judith Schmitz, Eleonora Bartoli, Laura Maffongelli, Luciano Fadiga, Nuria Sebastian-Galles, Alessandro D'Ausilio
Listening to speech has been shown to activate motor regions, as measured by corticobulbar excitability. In this experiment, we explored if motor regions are also recruited during listening to non-native speech, for which we lack both sensory and motor experience. By administering Transcranial Magnetic Stimulation (TMS) over the left motor cortex we recorded corticobulbar excitability of the lip muscles when Italian participants listened to native-like and non-native German vowels. Results showed that lip corticobulbar excitability increased for a combination of lip use during articulation and non-nativeness of the vowels...
January 6, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29317185/cortical-inhibition-assessed-using-paired-pulse-tms-eeg-is-increased-in-older-adults
#12
George M Opie, Simranjit K Sidhu, Nigel C Rogasch, Michael C Ridding, John G Semmler
BACKGROUND: Alterations in inhibitory processes mediated by gamma-aminobutyric acid type B (GABAB) receptors may contribute to age-related functional impairments. However, investigation of these circuits using conventional paired-pulse transcranial magnetic stimulation (TMS) at long interstimulus intervals (∼100-200ms) have produced conflicting results in older adults, possibly due to the indirect nature of the TMS motor evoked potential (MEP). OBJECTIVE: To utilise electroencephalography and TMS coregistration (TMS-EEG) to more directly assess age-related changes in GABAB-mediated long-interval intracortical inhibition (LICI)...
December 30, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29312729/diagnostic-accuracy-of-tumor-markers-for-malignant-pleural-effusion-a-derivation-and-validation-study
#13
Kan Zhai, Wen Wang, Yao Wang, Jing-Yuan Liu, Qiong Zhou, Huan-Zhong Shi
Background: The utility of tumor markers (TMs) for differentiating malignant pleural effusion (MPE) from benign pleural effusion (BPE) has been a subject of controversy. The majority of published studies are single center designed and lack validation. We performed a derivation and validation study in China to evaluate the diagnostic value of carcinoembryonic antigen (CEA) as well as carbohydrate antigen (CA) 15-3, CA 19-9 and CA 125 to differentiate between MPE and BPE. Methods: Three hundred and twenty seven pleural effusion (PE) and paired serum samples were collected from consecutive patients with MPE or BPE in Beijing (174 patients, derivation) and Wuhan (153 patients, validation) during the same period...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29312553/development-of-novel-target-modules-for-retargeting-of-unicar-t-cells-to-gd2-positive-tumor-cells
#14
Nicola Mitwasi, Anja Feldmann, Ralf Bergmann, Nicole Berndt, Claudia Arndt, Stefanie Koristka, Alexandra Kegler, Justyna Jureczek, Anja Hoffmann, Armin Ehninger, Marc Cartellieri, Susann Albert, Claudia Rossig, Gerhard Ehninger, Jens Pietzsch, Jörg Steinbach, Michael Bachmann
As the expression of a tumor associated antigen (TAA) is commonly not restricted to tumor cells, adoptively transferred T cells modified to express a conventional chimeric antigen receptor (CAR) might not only destroy the tumor cells but also attack target-positive healthy tissues. Furthermore, CAR T cells in patients with large tumor bulks will unpredictably proliferate and put the patients at high risk of adverse side effects including cytokine storms and tumor lysis syndrome. To overcome these problems, we previously established a modular CAR technology termed UniCAR: UniCAR T cells can repeatedly be turned on and off via dosing of a target module (TM)...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29309536/the-neural-specificity-of-movement-preparation-during-actual-and-imagined-movements
#15
Florent Lebon, Célia Ruffino, Ian Greenhouse, Ludovica Labruna, Richard B Ivry, Charalambos Papaxanthis
Current theories consider motor imagery, the mental representation of action, to have considerable functional overlap with the processes involved in actual movement preparation and execution. To test the neural specificity of motor imagery, we conducted a series of 3 experiments using transcranial magnetic stimulation (TMS). We compared changes in corticospinal excitability as people prepared and implemented actual or imagined movements, using a delayed response task in which a cue indicated the forthcoming response...
January 4, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29308819/phase-controllable-fabrication-of-zinc-cobalt-sulfide-hollow-polyhedra-as-high-performance-electrocatalysts-for-the-hydrogen-evolution-reaction
#16
Bowei Zhang, Guang Yang, Chaojiang Li, Kang Huang, Junsheng Wu, Shiji Hao, Jianyong Feng, Dongdong Peng, Yizhong Huang
Structure and phase modulations allow the development of highly active, cost-effective and stable electrocatalysts for the hydrogen evolution reaction (HER) but are rather challenging. In this paper, Zn-Co-S hollow/porous polyhedra with controllable phases were fabricated via solvent-based sulfidation at room temperature followed by thermal annealing. The obtained hollow structure Zn-Co-S-300 with an amorphous phase exhibits excellent electrocatalytic HER activity, which is higher than crystalline Zn-Co sulfides annealed at a higher temperature...
January 8, 2018: Nanoscale
https://www.readbyqxmd.com/read/29307324/evaluation-of-cognition-and-cortical-excitability-in-huntington-s-disease
#17
Nitish Kamble, M Netravathi, B C Nagaraju, Abhishek Lenka, Keshav Kumar, V Sowmya, Sanjeev Jain, Pramod Kumar Pal
BACKGROUND: Recent advances in neurophysiological techniques have contributed to our understanding of the pathophysiology of Huntington's disease (HD). Studies of the motor cortical excitability and central motor pathways have shown variable results. OBJECTIVES: Our aims were to evaluate the cortical excitability changes in HD using transcranial magnetic stimulation (TMS) and correlate the changes with cognitive impairment. METHODS: The study included 32 HD patients and 30 age- and gender-matched controls...
January 8, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29307264/from-goals-to-muscles-motor-familiarity-shapes-the-representation-of-action-related-sounds-in-the-human-motor-system
#18
Luca F Ticini, Simone Schütz-Bosbach, Florian Waszak
Numerous studies corroborated the idea that the sound of familiar motor acts triggers a muscle-specific replica of the perceived actions in the listener's brain. We recently contradicted this conclusion by demonstrating that the representation of newly-learned action-related sounds is not somatotopically organised but rather it corresponds to the goal a particular action aims to achieve. In the present study, we reconciled these contrasting results by showing that a higher degree of motor familiarity obtained via long-term practice with auditory-motor associations shapes a somatotopically organised representation of action-related sounds...
January 8, 2018: Cognitive Neuroscience
https://www.readbyqxmd.com/read/29307007/neurophysiology-and-neurochemistry-of-corticobasal-syndrome
#19
REVIEW
Aditya A Murgai, Mandar S Jog
Corticobasal syndrome is a rare neurodegenerative disorder, which presents with a progressive, asymmetrical, akinetic rigid syndrome and early cortical signs. However, clinical, pathological, and electrophysiological heterogeneity makes the understanding of this syndrome challenging. Corticobasal syndrome can have various pathological substrates including corticobasal degeneration, Alzheimer's disease, Fronto-temporal degeneration with TDP inclusions, Creutzfeldt-Jakob disease, and progressive supranuclear palsy (PSP)...
January 6, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29305917/motor-imagery-of-voluntary-muscle-relaxation-of-the-foot-induces-a-temporal-reduction-of-corticospinal-excitability-in-the-hand
#20
Kouki Kato, Kazuyuki Kanosue
The object of this study was to clarify how the motor imagery of foot muscle relaxation influences corticospinal excitability for the ipsilateral hand. Twelve participants volitionally relaxed their right foot from a dorsiflexed position (actual relaxation), or imaged the same movement (imagery relaxation) in response to an auditory cue. Transcranial magnetic stimulation (TMS) was delivered to the hand area of the left primary motor cortex at different time intervals after an auditory cue. Motor evoked potentials (MEPs) were recorded from the right extensor carpi radialis (ECR) and flexor carpi radialis (FCR)...
January 3, 2018: Neuroscience Letters
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