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Gastric emptying

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https://www.readbyqxmd.com/read/29329510/the-predictive-value-of-hunger-score-on-gastric-evacuation-after-oral-intake-of-carbohydrate-solution
#1
Qiu Weiji, Li Shitong, Luo Yu, Hua Tianfang, Kong Ning, Zhang Lina
BACKGROUND: Surgical patients are asked to fast for a sufficient duration to ensure that the amount of residual liquid in the stomach is within the safe range, thereby reducing the risk of gastric reflux perioperatively. The authors hypothesized that subjective hunger numerical rating scale (NRS) score could also help assess the process of gastric emptying and determine the amount of fluid remaining in the stomach. METHODS: The current study consisted of healthy volunteers recruited by advertisement and mutual introduction...
January 12, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29325788/impact-of-the-gastrojejunal-anatomic-position-as-the-mechanism-of-delayed-gastric-emptying-after-pancreatoduodenectomy
#2
Motoi Nojiri, Yukihiro Yokoyama, Takashi Maeda, Tomoki Ebata, Tsuyoshi Igami, Gen Sugawara, Junpei Yamaguchi, Masato Nagino
BACKGROUND: This study investigated the impact of gastrojejunal anatomic position on the incidence of delayed gastric emptying after pancreatoduodenectomy. METHODS: A total of 160 patients were included in the retrospective analysis. The relative anatomic position of the gastrojejunostomy was evaluated using coronal and sagittal plane computed tomography images on postoperative day 7; the coronal cardia anastomotic angle and the sagittal fundus anastomotic angle were measured...
January 8, 2018: Surgery
https://www.readbyqxmd.com/read/29325351/-analysis-of-risk-factors-and-outcomes-for-delayed-gastric-emptying-following-pancreaticoduodenectomy-a-single-center-experience-of-492-cases
#3
J Yin, Z P Lu, K Zhang, J L Wu, W T Gao, F Guo, J M Chen, J S Wei, P F Wu, D Xu, K R Jiang, Y Miao
Objective: To evaluate risk factors for delayed gastric emptying(DGE)following pancreaticoduodenectomy(PD). Methods: There were 492 consecutive patients who underwent PD in Pancreas Center, the First Affiliated Hospital with Nanjing Medical University between January 2012 and December 2014 were identified from a prospective database.There were 315 male and 177 female patients with a median age of 60.5 years.Univariate and multivariate analyses were performed to investigate the independent risk factors for clinically relevant DGE(CR-DGE)...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29325236/treatment-with-a-ghrelin-agonist-in-outpatient-women-with-anorexia-nervosa-a-randomized-clinical-trial
#4
Pouneh K Fazeli, Elizabeth A Lawson, Alexander T Faje, Kamryn T Eddy, Hang Lee, Fred T Fiedorek, Anne Breggia, Ildiko M Gaal, Rebecca DeSanti, Anne Klibanski
OBJECTIVE: To assess the effects of relamorelin-an agonist of the appetite-stimulating hormone ghrelin, which has effects on gastric emptying-on (1) weight gain and (2) gastric emptying in women with anorexia nervosa. METHODS: In a randomized, double-blind, placebo-controlled design, the effects of the ghrelin agonist relamorelin were studied in 22 outpatient women with anorexia nervosa, diagnosed using DSM-5 criteria. The study was conducted at the Massachusetts General Hospital Clinical Research Center between March 11, 2013, and February 26, 2015...
January 2, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29322315/effects-of-a-casein-hydrolysate-versus-intact-casein-on-gastric-emptying-and-amino-acid-responses
#5
Katy Horner, Elaine Drummond, Victoria O'Sullivan, Pedapati S C Sri Harsha, Lorraine Brennan
PURPOSE: Milk proteins and/or their hydrolysates have been reported to have beneficial effects for improving postprandial glycaemia. Gastric emptying is a major determinant of postprandial glycaemia, yet limited studies have examined the effects of intact milk proteins compared to hydrolysates on gastric emptying. We investigated gastric emptying of a casein hydrolysate compared to intact casein. METHODS: Nine overweight and obese adults (mean ± SD age: 59...
January 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29318852/-effects-of-electroacupuncture-on-ultrastructure-of-interstitial-cells-of-cajal-and-stem-cell-factor-kit-signal-pathway-of-gastric-antrum-in-diabetic-gastroparesis-rats
#6
Cheng-Cheng Zhang, Ya-Ping Lin, Yan Peng, Zeng-Hui Yue, Hai-Jiao Chen, Jian-Wen Yang, Wei-Wei Liu, Li Liu
OBJECTIVE: To observe the effects of electroacupuncture (EA) on gastrointestinal motility and the ultrastructure of interstitial cells of Cajal (ICC) and the expressions of c-kit receptor protein and stem cell factor (SCF) mRNA in diabetic gastroparesis (DGP) rats, so as to explore its mechanism. METHODS: Fifty SD rats were randomly divided into normal, model, acupoint, non-acupoint and metoclopramide groups (n=10 rats/group). DGP model was established by intraperitoneal injection of streptozotocin (STZ, 2%), and raised with high-sugar high-fat diet irregularly...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29316561/the-vertical-array-reconstruction-technique-in-pylorus-preserving-pancreatoduodenectomy
#7
Shinjiro Kobayashi, Satoshi Koizumi, Takashi Hatori, Kouhei Segami, Hiroyuki Hoshino, Takehito Otsubo
BACKGROUND/AIMS: We describe a new reconstruction method of duodenojejunal anastomosis, the "vertical array reconstruction" (VAR) technique, following pylorus-preserving pancreatoduodenectomy (PPPD). METHODS: The VAR technique aligns the stomach, duodenum, and jejunal loop vertically along the body's longitudinal axis. It was performed in 120 consecutive patients (between June 2008 and October 2015) who underwent PPPD. We evaluated the incidence of delayed gastric emptying (DGE)...
January 9, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29316479/response-of-cell-lines-to-actual-and-simulated-inoculation-with-cryptosporidium-proliferans
#8
Janka Melicherová, Lada Hofmannová, Andrea Valigurová
The need for an effective treatment against cryptosporidiosis has triggered studies in the search for a working in vitro model. The peculiar niche of cryptosporidia at the brush border of host epithelial cells has been the subject of extensive debates. Despite extensive research on the invasion process, it remains enigmatic whether cryptosporidian host-parasite interactions result from an active invasion process or through encapsulation. We used HCT-8 and HT-29 cell lines for in vitro cultivation of the gastric parasite Cryptosporidium proliferans strain TS03...
December 15, 2017: European Journal of Protistology
https://www.readbyqxmd.com/read/29313122/influence-of-antrum-size-on-gastric-emptying-and-weight-loss-outcomes-after-laparoscopic-sleeve-gastrectomy-preliminary-analysis-of-a-randomized-trial
#9
Meritxell Garay, Carmen Balagué, Carlos Rodríguez-Otero, Berta Gonzalo, Anna Domenech, Juan Carlos Pernas, Ignasi J Gich, Inka Miñambres, Sonia Fernández-Ananín, Eduardo M Targarona
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has increased in popularity in recent years as a definitive bariatric procedure. Despite its growing popularity worldwide, the surgical technique is not well standardized. There is a lack of evidence on the matter of the antrum size and its relation to gastric emptying and weight-loss outcomes. The aim of the study is to evaluate the influence of antrum size over gastric emptying and weight-loss outcomes. METHODS: Twenty-five patients were prospectively randomized according to the distance between the first firing and the pylorus: AR group (antrum resection-2 cm from the pylorus) and AP group (antrum preservation-5 cm from the pylorus)...
January 8, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29299977/utility-of-food-pellets-containing-1-aminobenzotriazole-for-longer-term-in-vivo-inhibition-of-cytochrome-p450-in-mice
#10
Rowan Stringer, Valerie Cordier, Catherine Afatsawo, Philip Arabin, Sandrine Desrayaud, Laurent Hoffmann, Daniel Lehmann, Philip John Lowe, Francis Risser, Julia Thiel, Toni Widmer, Peter Wipfli, Marc Bigaud
1. The utility of 1-aminobenzotriazole (ABT), incorporated in food, has been investigated as an approach for longer term inhibition of cytochrome P450 (P450) enzymes in mice. 2. In rats ABT inhibits gastric emptying, to investigate this potential limitation in mice we examined the effect of ABT administration on the oral absorption of NVS-CRF38. Two hour prior oral treatment with 50 mg/kg ABT inhibited the oral absorption of NVS-CRF38, Tmax was 4 hours for ABT treated mice compared to 0.5 hours in the control group...
January 4, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29298479/gastric-emptying-and-small-bowel-water-content-after-administration-of-grapefruit-juice-compared-to-water-and-iso-caloric-solutions-of-glucose-and-fructose-a-four-way-crossover-mri-pilot-study-in-healthy-subjects
#11
Michael Grimm, Mirko Koziolek, Marwa Saleh, Felix Schneider, Grzegorz Garbacz, Jens Peter Kuhn, Werner Weitschies
Grapefruit juice (GFJ) is known to affect the bioavailability of drugs in different ways. Despite the influence on gastrointestinal enzymes and transporters, the influence on gastrointestinal fluid kinetics is regarded to be relevant for the absorption of several drugs. Thus, it was the aim of this pilot study to investigate the gastric and intestinal volumes after intake of GFJ compared to isocaloric fructose and glucose solutions and water. The gastric and small intestinal volume kinetics after intake of 240 mL of GFJ, 10...
January 3, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29296572/feasibility-study-of-structured-diagnosis-methods-for-functional-dyspepsia-in-korean-medicine-clinics
#12
Jeong Hwan Park, Soyoung Kim, Jae-Woo Park, Seok-Jae Ko, Sanghun Lee
Background: Functional dyspepsia (FD) is the seventh most common disease encountered in Korean medicine (KM) clinics. Despite the large number of FD patients visiting KM clinics, the accumulated medical records have no utility in evidence development, due to being unstructured. This study aimed to construct a standard operating procedure (SOP) with appropriate structured diagnostic methods for FD, and assess the feasibility for use in KM clinics. Methods: Two rounds of professional surveys were conducted by 10 Korean internal medicine professors to select the representative diagnostic methods...
December 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/29296567/carthami-flos-regulates-gastrointestinal-motility-functions
#13
Iksung Kim, Jinsoo Bae, Byung Joo Kim
Background: Gastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of Carthami flos (CF), a natural product, on GI motility. Methods: We checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice in vivo. The GMD mice were made by acetic acid or streptozotocin. Results: Both ITRs and gastric emptying were increased by CF (0.0025-0...
December 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/29280667/-intragastric-injection-of-botulinum-toxin-a-real-alternative-for-obesity-treatment-a-systematic-review
#14
Francisco José Sánchez Torralvo, Sergio Valdés Hernández, María José Tapia, José Abuín Fernández, Gabriel Olveira
BACKGROUND: Obesity is a prevalent disease in our environment, which comorbidities suppose a great challenge to public health. Intragastric injection of botulinum toxin has been used as treatment for obesity, both in humans and animals. It acts by inhibiting gastric emptying and inducing early satiety, consequently reducing intake and finally achieving weight loss. MATERIALS AND METHODS: A bibliographic search in PubMed, Scopus and EMBASE databases between 2000 and 2016 was carried out...
November 16, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29278279/a-randomized-double-blind-placebo-controlled-trial-of-camicinal-in-parkinson-s-disease
#15
Sarah L Marrinan, Tal Otiker, Lakshmi S Vasist, Rachel A Gibson, Bhopinder K Sarai, Matthew E Barton, Duncan B Richards, Per M Hellström, Dag Nyholm, George E Dukes, David J Burn
BACKGROUND: Delayed gastric emptying may impair l-dopa absorption, contributing to motor fluctuations. We evaluated the effect of camicinal (GSK962040), a gastroprokinetic, on the absorption of l-dopa and symptoms of PD. METHODS: Phase II, double-blind, placebo-controlled trial. Participants were randomized to receive camicinal 50 mg once-daily (n = 38) or placebo (n = 20) for 7 to 9 days. RESULTS: l-dopa exposure was similar with coadministration of camicinal compared to placebo...
December 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29276629/should-workers-avoid-consumption-of-chilled-fluids-in-a-hot-and-humid-climate
#16
REVIEW
Matt B Brearley
Despite provision of drinking water as the most common method of occupational heat stress prevention, there remains confusion in hydration messaging to workers. During work site interactions in a hot and humid climate, workers commonly report being informed to consume tepid fluids to accelerate rehydration. When questioned on the evidence supporting such advice, workers typically cite that fluid absorption is delayed by ingestion of chilled beverages. Presumably, delayed absorption would be a product of fluid delivery from the gut to the intestines, otherwise known as gastric emptying...
December 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/29274173/investigation-of-autophagy-and-differentiation-of-myenteric-interstitial-cells-of-cajal-in-the-pathogenesis-of-gastric-motility-disorders-in-rats-with-functional-dyspepsia
#17
Li-Min Zhang, Li-Jun Zeng, Jing Deng, Yu-Qin Zhang, Yu-Jiao Wang, Tian-Yi Xie, Jiang-Hong Ling
BACKGROUND: Interstitial cells of Cajal (ICC), especially myenteric interstitial cells of Cajal (ICC-MY), are key to gastrointestinal motility. However, their role in the pathogenesis of functional dyspepsia (FD) is unclear. Therefore, autophagy and differentiation of ICC-MY were investigated to elucidate the pathogenesis of gastric motility disorder in FD. METHODS: FD model was induced by chronic stress via tail clamping in rats, which was assessed by the vital signs of rats, gastric emptying rate result and histology...
December 23, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29261527/preoperative-evaluation-is-not-predictive-of-transpyloric-feeding-conversion-in-gastrostomy-dependent-pediatric-patients
#18
Maireade McSweeney, Jessica Kerr, Janine Amirault, Eliza Fishman, Margot Lurie, Maria I Peinado-Fabregat, Paul D Mitchell, Rachel Rosen
OBJECTIVES: Limited literature exists as to whether preoperative gastrostomy (GT)evaluation may predict which patients will go onto require gastrojejunostomy tube (GJ) feeding. The goal of this study was to compare the preoperative evaluations between patients maintained on GT feeds versus patients who required conversion to GJ feeds. METHODS: We identified patients at Boston Children's Hospital who underwent GT placement and required GJ feeding between 2006-2012...
December 19, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29261525/pylorus-resection-does-not-reduce-delayed-gastric-emptying-after-partial-pancreatoduodenectomy-a-blinded-randomized-controlled-trial
#19
Anand Narayan Singh, Ragini Kilambi
No abstract text is available yet for this article.
December 19, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29260924/pharmacokinetic-drug-evaluation-of-exenatide-for-the-treatment-of-type-2-diabetes
#20
María Molina Vega, Araceli Muñoz-Garach, Francisco J Tinahones
INTRODUCTION: Glucagon-like peptide-1 (GLP-1) receptor analogs are a group of therapeutic agents which mimic endogenous GLP-1, exerting their effect by the stimulation of the GLP-1 receptor with a wide distribution. Its activation increases insulin releasing dependent on blood glucose levels, suppression of glucagon secretion and a reduction of hepatic glucose output. It delays gastric emptying and increases satiety. Exenatide is the synthetic version of exendin-4, a natural peptide with similar properties to human GLP-1...
December 20, 2017: Expert Opinion on Drug Metabolism & Toxicology
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