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Recurrence hepatocellular carcinoma after liver resection

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https://www.readbyqxmd.com/read/28105190/prognostic-significance-of-akr1b10-gene-expression-in-hepatocellular-carcinoma-and-surrounding-non-tumorous-liver-tissue
#1
Fuminori Sonohara, Yoshikuni Inokawa, Mitsuhiro Hishida, Mitsuro Kanda, Yoko Nishikawa, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Yasuhiro Kodera, Shuji Nomoto
When assessing outcome in hepatocellular carcinoma (HCC), it is important to consider prognostic factors in background non-tumorous liver tissue as well as in the tumor, since multiple occurrence is associated with background liver status such as hepatitis. The current study aimed to elucidate molecular prognostic predictors that have an association with HCC background non-tumorous tissue. Microarray expression profiling identified aldo-keto reductase family 1, member B10 (AKR1B10) as a putative non-tumorous prognostic factor, and AKR1B10 gene expression was investigated in 158 curatively resected HCC cases by reverse transcription-quantitative polymerase chain reaction...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105115/hepatic-resection-versus-transarterial-chemoembolization-for-patients-with-barcelona-clinic-liver-cancer-intermediate-stage-child-pugh-a-hepatocellular-carcinoma
#2
Yin-Nong Zhao, Yong-Quan Zhang, Jia-Zhou Ye, Xing Liu, Hong-Zhi Yang, Feng-Yun Cong, Bang-De Xiang, Fei-Xiang Wu, Liang Ma, Le-Qun Li, Hai-Hong Ye
The present study aimed to compare the overall and recurrence-free survival rates following hepatic resection (HR) and transcatheter arterial chemoembolization (TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) classified intermediate-stage Child-Pugh A hepatocellular carcinoma (HCC). A total of 443 patients were examined, among whom 274 underwent HR, whereas 169 received TACE. The overall survival, recurrence-free survival between groups and subgroups, and risk factors with respect to mortality and recurrence, were analyzed...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100188/high-expression-of-micro-rna-135a-in-hepatocellular-carcinoma-is-associated-with-recurrence-within-12%C3%A2-months-after-resection
#3
Johann von Felden, Denise Heim, Kornelius Schulze, Till Krech, Florian Ewald, Björn Nashan, Ansgar W Lohse, Henning Wege
BACKGROUND: Hepatocellular carcinoma has a dismal prognosis due to recurrence rates of up to 70% after curative resection. Early recurrence is driven by synchronous microscopic intrahepatic metastases. The predictive value of histological parameters is discussed controversially and adjuvant therapy is not established. The aim of this study was to identify patients at high risk for early intrahepatic recurrence by expression profiling of selected micro RNAs. METHODS: In 52 patients undergoing HCC resection between 2011 and 2014, liver and tumor tissue was collected during surgery...
January 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28100026/mir-203-inhibits-augmented-proliferation-and-metastasis-of-hepatocellular-carcinoma-residual-in-the-promoted-regenerating-liver
#4
Xiao-Bo Zheng, Xiao-Bo Chen, Liang-Liang Xu, Ming Zhang, Lei Feng, Peng-Sheng Yi, Jian-Wei Tang, Ming-Qing Xu
Liver resection is still the most commonly used therapeutic option for hepatocellular carcinoma (HCC) at present, and liver regeneration promotes HCC growth in the regenerating liver. The higher recurrence/metastasis of HCC is the main cause of death for HCC patients after liver resection. However, it remains unclear how to abolish the augmented growth and metastasis of the possible residual HCC induced by the promoted liver regeneration after liver resection. In this study, a rat model with liver cirrhosis and diffused HCC was established by Diethylnitrosamine administration, recombinant miR-203 adenovirus was administered to induce hepatic miR-203 overexpression and 30% partial hepatectomy (PH) was followed, then the effect of miR-203 on the proliferation, invasion and metastasis of the residual HCC in the remnant cirrhotic liver with promoted regeneration was investigated...
January 18, 2017: Cancer Science
https://www.readbyqxmd.com/read/28099960/prognostic-factors-after-curative-resection-for-single-lesion-hepatocellular-carcinoma-in-patients-with-normal-liver-function-a-historical-cohort-study
#5
Mitsugi Shimoda, Kazuma Tago, Masato Kato, Taku Aoki, Keiichi Kubota
BACKGROUND: Hepatic resection for hepatocellular carcinoma (HCC) is now established as the treatment most likely to yield the best outcome. We aimed to clarify the risk factors for HCC recurrence after curative resection of single HCC in patients with normal liver function (NLF). METHODS: The clinical records of 105 patients with NFL and a single HCC less than 5 cm in diameter who had undergone curative liver resection between April 2000 and January 2013 were investigated...
January 19, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28095820/microvascular-invasion-has-limited-clinical-values-in-hepatocellular-carcinoma-patients-at-barcelona-clinic-liver-cancer-bclc-stages-0-or-b
#6
Cheng Huang, Xiao-Dong Zhu, Yuan Ji, Guang-Yu Ding, Guo-Ming Shi, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun
BACKGROUND: Microvascular invasion (MVI) is recognized as a prognostic factor associated with poor outcome in hepatocellular carcinoma (HCC) patients after curative resection. It remains unclear, however, whether MVI can provide prognostic information for patients at a specific tumor stage. METHODS: Consecutive HCC patients who underwent curative resection in years of 2007 and 2008 (discovery cohort) were enrolled in this retrospective study. Patients were stratified by the Barcelona Clinic Liver Cancer (BCLC) staging system...
January 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28070200/the-risk-of-hepatocellular-carcinoma-after-directly-acting-antivirals-for-hepatitis-c-virus-treatment-in-liver-transplanted-patients-is-it-real
#7
Alessio Strazzulla, Rosa Maria Rita Iemmolo, Ennio Carbone, Maria Concetta Postorino, Maria Mazzitelli, Mario De Santis, Fabrizio Di Benedetto, Costanza Maria Cristiani, Chiara Costa, Vincenzo Pisani, Carlo Torti
INTRODUCTION: Since directly acting antivirals (DAAs) for treatment of hepatitis C virus (HCV) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (HCC) after interferon (IFN)-free treatments. We present a case of recurrent, extra-hepatic HCC in a liver-transplanted patient soon after successful treatment with DAAs, along with a short review of literature. CASE PRESENTATION: In 2010, a 53-year old man, affected by chronic HCV (genotype 1) infection and decompensated cirrhosis, underwent liver resection for HCC and subsequently received orthotopic liver transplantation...
November 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/28069527/liver-transplantation-for-advanced-hepatocellular-carcinoma-after-downstaging-without-up-front-stage-restrictions
#8
William C Chapman, Sandra Garcia-Aroz, Neeta Vachharajani, Kathryn Fowler, Nael Saad, Yiing Lin, Jason Wellen, Benjamin Tan, Adeel S Khan, Majella Doyle
BACKGROUND: The incidence of HCC continues to increase dramatically worldwide. Liver transplantation (LT) is now standard and optimal treatment for patients with HCC in the setting of cirrhosis, but only for tumors within Milan criteria (MC). In patients presenting beyond Milan, locoregional therapy (LRT) may downstage to within-Milan for consideration of LT. While controversial, the current study aims to evaluate the outcomes of LT in patients presenting with advanced stage HCC who underwent downstaging and compare to patients who meet Milan criteria at presentation...
January 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28052155/effect-of-background-liver-cirrhosis-on-outcomes-of-hepatectomy-for-hepatocellular-carcinoma
#9
Kazunari Sasaki, Junichi Shindoh, Georgios A Margonis, Yujiro Nishioka, Nikolaos Andreatos, Akinari Sekine, Masaji Hashimoto, Timothy M Pawlik
Importance: Background hepatocarcinogenesis is considered a major cause of postoperative recurrence of de novo hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). The degree of underlying liver injury has reportedly correlated with surgical outcomes of HCC. However, the pattern and annual rate of recurrence of postoperative de novo HCC are still unclear. Objective: To clarify the pattern and rate of recurrence of de novo HCC in patients with LC...
January 4, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28052154/association-of-remnant-liver-ischemia-with-early-recurrence-and-poor-survival-after-liver-resection-in-patients-with-hepatocellular-carcinoma
#10
Jai Young Cho, Ho-Seong Han, YoungRok Choi, Yoo-Seok Yoon, Sungho Kim, Jang Kyu Choi, Jae Seong Jang, Seong Uk Kwon, Haeryoung Kim
Importance: The remnant liver after hepatectomy may have inadequate blood supply, especially following nonanatomical resection or vascular damage. Objective: To evaluate whether remnant liver ischemia (RLI) may have an adverse effect on long-term survival and morbidity after liver resection in patients with hepatocellular carcinoma. Design, Setting, and Participants: This study was a retrospective analysis at Seoul National University Bundang Hospital...
January 4, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28050767/impact-of-viral-etiology-on-postoperative-de-novo-recurrence-after-hepatectomy-for-hepatocellular-carcinoma-in-cirrhotic-patients
#11
Kazunari Sasaki, Junichi Shindoh, Yujiro Nishioka, Georgios A Margonis, Toshitaka Sugawara, Nikolaos Andreatos, Masaji Hashimoto, Timothy M Pawlik
BACKGROUND AND AIM: Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) are associated with viral hepatitis, especially hepatitis B virus (HBV) and hepatitis C virus (HCV). Whether differences exist in postoperative de novo carcinogenesis from established cirrhosis according to viral etiology remains unclear. METHODS: Data from 313 LC patients with viral hepatitis (HBV-LC, n = 108 and HCV-LC, n = 205) who underwent curative-intent hepatectomy for HCC were retrospectively collected...
January 3, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28038442/mutations-acquired-by-hepatocellular-carcinoma-recurrence-give-rise-to-an-aggressive-phenotype
#12
Ji-Hye Choi, Min Jae Kim, Yong Keun Park, Jong-Yeop Im, So Mee Kwon, Hyung Chul Kim, Hyun Goo Woo, Hee-Jung Wang
Recurrence of hepatocellular carcinoma (HCC) even after curative resection causes dismal outcomes of patients. Here, to delineate the driver events of genomic and transcription alteration during HCC recurrence, we performed RNA-Seq profiling of the paired primary and recurrent tumors from two patients with intrahepatic HCC. By comparing the mutational and transcriptomic profiles, we identified somatic mutations acquired by HCC recurrence including novel mutants of GOLGB1 (E2721V) and SF3B3 (H804Y). By performing experimental evaluation using siRNA-mediated knockdown and overexpression constructs, we demonstrated that the mutants of GOLGB1 and SF3B3 can promote cell proliferation, colony formation, migration, and invasion of liver cancer cells...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28033289/liver-transplantation-versus-surgical-resection-for-hcc-meeting-the-milan-criteria-a-propensity-score-analysis
#13
Jun-Yi Shen, Chuan Li, Tian-Fu Wen, Lv-Nan Yan, Bo Li, Wen-Tao Wang, Jia-Yin Yang, Ming-Qing Xu, Tholakkara Nazar Highness
The optimal treatment (liver transplantation [LT] vs surgical resection [SR]) for early-stage hepatocellular carcinoma (HCC) remains controversial.A total of 209 SR patients and 129 LT patients were identified at our institution. After eliminating 27 patients with Child-Pugh C, the data from 209 SR patients and 102 LT patients were analyzed using a propensity score matching (PSM) model. Forty-six pairs were generated. A subgroup analysis was conducted based on the alpha-fetoprotein (AFP) level or platelet count (PLT)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28032575/liver-resection-versus-liver-resection-plus-tace-for-patients-with-hepatocellular-carcinoma-beyond-milan-criteria
#14
Chuan Li, Tian-Fu Wen, Lv-Nan Yan, Wu-Sheng Lu, Bo Li, Wen-Tao Wang, Ming-Qing Xu, Jia-Yin Yang
BACKGROUND: The recurrence of patients with hepatocellular carcinoma (HCC) beyond the Milan criteria after liver resection (LR) is common. This study aimed to clarify whether LR plus postoperative adjuvant transcatheter arterial chemoembolization (TACE) could improve the outcomes of patients with HCC beyond the Milan criteria after LR. METHODS: A total of 754 consecutive patients with HCC beyond the Milan criteria who received LR alone (n = 459) or LR + TACE (n = 295) were included...
October 4, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28013531/prognosis-of-hepatocellular-carcinoma-after-liver-transplantation-comparative-analysis-with-partial-hepatectomy
#15
Kyuho Lee, Kyoung-Bun Lee, Nam-Joon Yi, Kyung-Suk Suh, Ja-June Jang
BACKGROUND: Liver transplantation (LT) is the treatment of choice for hepatocellular carcinoma (HCC). The aim of this study was to investigate the recurrence rate of HCC after LT and prognostic factors for recurrence by comparing LT with non-transplanted resection. METHODS: The participants were 338 patients who underwent LT between 1996 and 2012 at Seoul National University Hospital (LT group) and 520 HCC patients who underwent partial hepatectomy between 1995 and 2006 (control group, non-LT group)...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28000365/preoperative-platelet-to-lymphocyte-ratio-can-predict-recurrence-beyond-the-milan-criteria-after-hepatectomy-for-patients-with-hepatocellular-carcinoma
#16
Takayoshi Kaida, Hidetoshi Nitta, Yuki Kitano, Kensuke Yamamura, Kota Arima, Takaaki Higashi, Katsunobu Taki, Shigeki Nakagawa, Hirohisa Okabe, Hiromitsu Hayashi, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba
AIM: Postoperative recurrence beyond the Milan criteria is a poor prognostic factor for patients with hepatocellular carcinoma (HCC) treated with various therapies. We investigated the most useful inflammation-based prognostic score for predicting recurrence beyond the Milan criteria after initial liver resection. METHODS: From January 2007 to December 2012, 271 consecutive patients with HCC who underwent curative liver resection were enrolled. Patients were divided according to the initial recurrence pattern: recurrence beyond the Milan criteria; and recurrence within the Milan criteria, or no recurrence...
November 2, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27980082/a-review-of-prognostic-scores-after-liver-resection-in-hepatocellular-carcinoma-the-mskcc-slicer-and-ssclip-scores
#17
REVIEW
Esther Ern-Hwei Chan, Pierce Kah-Hoe Chow
Predicting prognosis in hepatocellular carcinoma (HCC) aids clinical decision-making and stratifies patient follow-up plans. There are currently three prognostic scores specific to liver resection of HCC published in the literature: the MSKCC, SLICER and SSCLIP scores. In this review, we highlight the methodology employed in the construction of these scores and discuss the strengths and weaknesses of each. Current limitations to prognostic scores include the inability to differentiate between early and late recurrences of HCC, the failure to account for the impact of aetiology of HCC and the assumption that ethnicity has no impact on disease process...
December 15, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27931579/harm-and-benefits-of-salvage-transplantation-for-hepatocellular-carcinoma-an-updated-meta-analysis
#18
Q Xiong, T-T Geng, L He, H Gao
OBJECTIVE: The aim of this work was to compare salvage liver transplantation (SLT) and primary liver transplantation (PLT) in terms of the harm and benefits. METHODS: The authors searched Pubmed, Embase, and the Cochrane Library from their dates of establishment to December 2015. Based on selection and exclusion criteria, 2 researchers screened the literature independently. The meta-analysis was performed with the use of the Review Manager software. Meta-analysis of the pooled standard mean difference (SMD) and odds ratio (OR) with 95% confidence interval (CI) were calculated based on either a fixed-effects or a random-effects model...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27921278/bronchobiliary-fistula-caused-after-hepatectomy-for-hepatocellular-carcinoma-a-case-report
#19
Seikan Hai, Yuji Iimuro, Tadamichi Hirano, Kazuhiro Suzumura, Akito Yada, Jiro Fujimoto
BACKGROUND: A bronchobiliary fistula, an intercommunication between the biliary tract and bronchial trees, is an extremely rare complication after hepatectomy. CASE PRESENTATION: A 70-year-old male underwent partial resection of the liver for recurrent hepatocellular carcinoma under a thoracoabdominal approach. The immediate postoperative clinical course was uneventful, but the patient was febrile and laboratory examinations revealed leukocytosis on the 15th postoperative day...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27921059/duodenal-recurrence-of-fibrolamellar-carcinoma-12-years-after-partial-hepatectomy-and-adjuvant-chemotherapy
#20
Héctor Adrián Díaz Hernández, Ismael Antonio Gómez Ruiz, Aldo Torre
Fibrolamellar carcinoma (FLC) has a better prognosis than hepatocellular carcinoma; however, it is a highly recurrent disease. A 17-year-old woman presented with FLC with regional disease at the right lobe of the liver and underwent right hepatic lobe resection plus adjuvant chemotherapy with interferon α and adriamycin. She then presented at age 29 years with anemia. Endoscopy revealed an exofitic lesion in the duodenum, which was a recurrence of FLC. The patient underwent duodenal partial resection of a metastatic FLC tumor with disease-free edges and without neural or lymphoid-vascular involvement, a nonreported site of recurrence...
August 2016: ACG Case Reports Journal
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