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Recurrence hepatocellular carcinoma after liver resection

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https://www.readbyqxmd.com/read/29784036/long-versus-short-interval-follow-up-after-resection-of-hepatocellular-carcinoma-a-retrospective-cohort-study
#1
Wei He, Yun Zheng, Ruhai Zou, Jingxian Shen, Junping Yang, Jiliang Qiu, Qiang Tao, Wenwu Liu, Zhiwen Yang, Yuanping Zhang, Binkui Li, Yunfei Yuan
BACKGROUND: Average postoperative follow-up intervals vary in patients undergoing hepatocellular carcinoma (HCC) resection because of limited evidence regarding the optimal interval. We aimed to compare the associations of long-versus short-interval follow-up with survival and recurrence in risk-stratified HCC patients. METHODS: We performed a retrospective cohort study between 2007 and 2014. In total, 1227 patients treated by curative resection of Barcelona Clinic Liver Cancer stage A or B HCC were stratified as having a low (n = 865) or high (n = 362) risk of early recurrence (within the first 2 years after resection) based on prognostic factors identified by the least absolute shrinkage and selection operation algorithm...
May 21, 2018: Cancer communications
https://www.readbyqxmd.com/read/29754978/risk-stratification-using-a-novel-liver-functional-reserve-score-of-combination-prothrombin-time-international-normalized-ratio-to-albumin-ratio-and-albumin-in-patients-with-hepatocellular-carcinoma
#2
Koichiro Haruki, Hiroaki Shiba, Nobuhiro Saito, Takashi Horiuchi, Yoshihiro Shirai, Yuki Fujiwara, Kenei Furukawa, Taro Sakamoto, Katsuhiko Yanaga
BACKGROUND: Liver function in patients with hepatocellular carcinoma is generally graded according to the Child-Pugh system; however, some variables in the Child-Pugh grade are subjective. We developed a novel, objective score called the prothrombin time-international normalized ratio to albumin ratio. The aim of this study was to evaluate the prognostic value of this new score in patients with hepatocellular carcinoma after hepatic resection. METHODS: The study comprised 199 patients who underwent elective hepatic resection for hepatocellular carcinoma between January 2003 and December 2014...
May 10, 2018: Surgery
https://www.readbyqxmd.com/read/29740789/isolated-peritoneal-recurrence-after-liver-resection-for-hepatocellular-carcinoma
#3
Narendra Pandit, Laligen Awale, Sameer Chaudhary, Rajan Shah, Shailesh Adhikary
No abstract text is available yet for this article.
May 9, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29736665/prognosis-of-hepatocellular-carcinoma-patients-who-achieved-long-term-recurrence-free-survival-after-curative-therapy-impact-of-the-albi-grade
#4
Hajime Matsushima, Yuko Takami, Tomoki Ryu, Munehiro Yoshitomi, Masaki Tateishi, Yoshiyuki Wada, Hideki Saitsu
BACKGROUND/AIMS: Some patients experience very late recurrence of HCC more than 5 years after initial therapy. We aimed to clarify the predictive factors for very late recurrence of HCC in such cases. METHODS: Among 807 HCC patients undergoing surgical resection or ablative therapy with curative intent, the patients who survived for 5 years without any recurrence were reviewed. The prognosis and possible predictive factors for late recurrence were analyzed retrospectively...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29730905/assessment-of-the-surveillance-interval-at-1-year-after-curative-treatment-in-hepatocellular-carcinoma-risk-stratification
#5
Minjong Lee, Young Chang, Sohee Oh, Young Youn Cho, Dhong-Eun Jung, Hong Hyun Kim, Joon Yeul Nam, Hyeki Cho, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Nam-Joon Yi, Kwang-Woong Lee, Dong Ho Lee, Jeong Min Lee, Jung-Hwan Yoon, Kyung-Suk Suh, Yoonjun Kim
Background/Aims: Guidelines recommend surveillance for hepatocellular carcinoma (HCC) recurrence at 3-month intervals during the first year after curative treatment and 6-month intervals thereafter in all patients. This strategy does not reflect individual risk of recurrence. We aimed to stratify risk of recurrence to optimize surveillance intervals during the first year after treatment. Methods: We retrospectively analyzed 1,316 HCC patients treated with resection/radiofrequency ablation at Barcelona Clinic Liver Cancer stage 0/A...
May 4, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29721707/resected-primary-mucinous-cholangiocarcinoma-of-the-liver
#6
Kei Hagiwara, Kenichiro Araki, Takahiro Yamanaka, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Norifumi Harimoto, Hiroyuki Kuwano, Sumito Nobusawa, Shinichi Aishima, Ken Shirabe
BACKGROUND: Mucinous cholangiocarcinoma (MC) is a very rare variant of intrahepatic cholangiocarcinoma. MC is characterized by rapid growth, widespread metastasis, and poor prognosis. We report a case of resected MC of the liver. CASE PRESENTATION: We found a 13.6-cm hypovascular tumor in the left hepatic lobe of a 68-year-old man, which we initially diagnosed as a mass-forming intrahepatic cholangiocarcinoma. Left lobe and caudate resection was performed without major intraoperative or postoperative complications...
May 2, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29719937/a-novel-rna-sequencing-based-mirna-signature-predicts-with-recurrence-and-outcome-of-hepatocellular-carcinoma
#7
Bai Fumao, Huaibin Zhou, Mengni Ma, Chen Guan, Jianxin Lyu, Qing H Meng
Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the second leading cause of cancer-related deaths worldwide. Given that the rate of HCC recurrence 5 years after liver resection is as high as 70%, patient with HCC typically have a poor outcome. A biomarker or set of biomarkers that could predict disease recurrence would have a substantial clinical impact, allowing earlier detection of recurrence and more effective treatment. With the aim of identifying a new microRNA (miRNA) signature associated with HCC recurrence, we analyzed data on 306 HCC patients for whom both miRNA expression profiles and complete clinical information were available from The Cancer Genome Atlas (TCGA) database...
May 2, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29715160/the-emerging-role-of-laparoscopic-liver-resection-in-the-treatment-of-recurrent-hepatocellular-carcinoma-a-systematic-review
#8
Nikolaos Machairas, Dimitrios Papaconstantinou, Paraskevas Stamopoulos, Anastasia Prodromidou, Zoe Garoufalia, Eleftherios Spartalis, Ioannis D Kostakis, Georgios C Sotiropoulos
BACKGROUND/AIM: Tumor recurrence complicates more than half of patients at 5 years after primary hepatocellular carcinoma (HCC) resection. Repeat open liver resection (ROLR) is the standard procedure for patients eligible for repeat resection, whereas laparoscopic repeat liver resection (RLLR) has been proposed as an alternative approach. The aim of this systematic review is to evaluate studies reporting on outcomes of RLLR for recurrent HCC (rHCC). MATERIALS AND METHODS: A comprehensive search of the literature was undertaken...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29707155/tissue-mirna-483-3p-expression-predicts-tumor-recurrence-after-surgical-resection-in-histologically-advanced-hepatocellular-carcinomas
#9
Francesco Vasuri, Silvia Fittipaldi, Vanessa De Pace, Laura Gramantieri, Valentina Bertuzzo, Matteo Cescon, Antonio D Pinna, Michelangelo Fiorentino, Antonia D'Errico, Matteo Ravaioli
The choice of surgical treatment for hepatocellular carcinoma (HCC) depends on several prognostic variables, among which histological features, like microvascular invasion and tumor grade, are well established. This study aims to identify the tissue miRNAs predictive of recurrence after liver resection in "histologically advanced" HCC. We selected 54 patients: 15 retrospective resected patients without recurrence (group A), 19 retrospective resected patients with HCC recurrence (group B), and 20 prospective patients (group C), with 4 recurrence cases...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29702975/primary-functioning-hepatic-paraganglioma-mimicking-hepatocellular-carcinoma-a-case-report-and-literature-review
#10
Wei Liao, Ze-Yang Ding, Binhao Zhang, Lin Chen, Gan-Xun Li, Jing-Jing Wu, Bixiang Zhang, Xiao-Ping Chen, Peng Zhu
INTRODUCTION: Hepatic paraganglioma (HPGL) originates from the sympathetic nervous tissue in the liver, and is an extremely rare type of the sympathetic paragangliomas. Till now, only 11 HPGL cases have been reported. CASE PRESENTATION: A 49-year-old woman presented to our hospital with a lesion in the right lobe of the liver, which grew from 2 to 6 cm in 2 years. In addition, she had a 6-year history of diabetes. The patient was initially diagnosed as hepatocellular carcinoma and hepatectomy was performed...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29690860/low-expression-of-c-myc-protein-predicts-poor-outcomes-in-patients-with-hepatocellular-carcinoma-after-resection
#11
Fei Ji, Zhi-Heng Zhang, Yi Zhang, Shun-Li Shen, Qing-Hua Cao, Long-Juan Zhang, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua
BACKGROUND: Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signaling. c-Myc is an important oncogenic transcription factor, and the disruption of TGF-β signaling promotes c-Myc-induced hepatocellular carcinoma (HCC) carcinogenesis. However, the prognostic significance of c-Myc in HCC is less understood METHODS: The expression of c-Myc protein and mRNA were measured by immunohistochemistry (IHC) and qRT- PCR, respectively...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29650918/-hepatocellular-carcinoma-with-bile-duct-thrombosis-a-case-report
#12
Masaru Kubota, Yasuji Hashimoto, Hiroki Imamura, Yuriko Yagi, Takashi Noma, Yukako Mokutani, Kenichi Nagai, Hajime Hirose, Yoshihito Ide, Jin Matsuyama, Yukio Fukushima, Yousuke Nishioka, Masashi Takeda, Shigeyuki Tamura, Yo Sasaki
Hepatocellular carcinoma(HCC)is not commonly observed with bile duct thrombosis.Here, we report a case of HCC with bile thrombi that extended to the liver hilum.The patient was a 61-year-old man who visited us due to untreated type B hepatitis.He underwent screening with a CT scan that revealed LDA on the right posterior lobe of his liver with infiltration of the bile duct.Generally, bile resection and reconstruction should be considered for curative resection for bile thrombi; however, we attempted to conserve the common bile duct to preserve the options of percutaneous therapy in case of tumor recurrence...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29628773/the-mutation-of-hepatitis-b-virus-and-the-prognosis-of-hepatocellular-carcinoma-after-surgery-a-pilot-study
#13
Yaojun Zhang, Junting Huang, Jinbin Chen, Keli Yang, Jiancong Chen, Li Xu, Zhongguo Zhou, Minshan Chen
Background: Although hepatitis B virus (HBV) is still one of the most common etiological factors for hepatocellular carcinoma (HCC), the association between the HBV mutations and the clinical characteristics and prognosis of HBV-related HCC patients (HBV-HCC) after surgical resection remains largely unknown. Materials and methods: A cohort of 131 consecutive patients who received hepatectomy for HBV-HCC were retrospectively enrolled. The HBV genotype and 14 genomic mutations, which have been reported to relate to HCC in liver samples, were sequenced...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29624843/a-novel-multimarker-assay-for-the-phenotypic-profiling-of-circulating-tumor-cells-in-hepatocellular-carcinoma
#14
Colin M Court, Shuang Hou, Paul Winograd, Nicholas H Segel, Qingyu Wilda Li, Yazhen Zhu, Saeed Sadeghi, Richard S Finn, Ekambaram Ganapathy, Min Song, Samuel W French, Bita V Naini, Shonan Sho, Fady M Kaldas, Ronald W Busuttil, James S Tomlinson, Hsian-Rong Tseng, Vatche G Agopian
Current clinicopathologic staging systems and serum biomarkers poorly discriminate tumor biology in hepatocellular carcinoma (HCC), with high recurrence rates following curative-intent surgical resection and liver transplantation (LT). Identification of accurate biomarkers for improved prognostication and treatment selection is a critical unmet need. We sought to develop a novel "liquid-biopsy" assay capable of detecting HCC circulating tumor cells (CTCs), and characterizing phenotypic subpopulations with prognostic significance...
April 6, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29621282/predictive-value-of-the-preoperative-neutrophil-to-lymphocyte-ratio-for-the-development-of-hepatocellular-carcinoma-in-hbv-associated-cirrhotic-patients-after-splenectomy
#15
Zhaoqing Du, Jian Dong, Jianbin Bi, Ruhai Bai, Jia Zhang, Zheng Wu, Yi Lv, Xufeng Zhang, Rongqian Wu
The neutrophil to lymphocyte ratio (NLR), a simple marker of inflammation, has recently been showed to predict tumor recurrence in hepatocellular carcinoma (HCC) patients after hepatic resection or liver transplantation. However, whether it can be used to predict HCC development in cirrhotic patients remained unknown. The aim of this study was to evaluate the predictive value of the preoperative NLR for the development of HCC in cirrhotic patients who underwent splenectomy. A total of 230 HBV-associated cirrhotic patients who underwent splenectomy in our hospital from January 2000 to December 2012 were included in this study...
2018: PloS One
https://www.readbyqxmd.com/read/29575841/-clinical-application-of-ldlt-after-reconstruction-of-ivc-using-artificial-blood-vessel-in-the-treatment-of-hcc-beyond-milan-criteria
#16
B C Sun, G Q Li, X L Huang, J J Qin, X X Mu
Objective: To assess application of reconstruction of retrohepatic inferior vena cava using artificial blood vessel in right lobe living donor liver transplantation (LDLT) in the treatment of hepatocellular carcinoma (HCC) beyond Milan Criteria. Methods: The clinical data of 9 HCC patients who underwent right lobe liver transplantation after reconstruction of retrohepatic inferior vena cava using artificial blood vessel between June 2015 and Nov 2016 at Liver Transplantation Center of the First Affiliated Hospital of Nanjing Medical University were retrospectively analyzed...
March 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29563807/overexpression-of-c-kit-cd117-relevant-with-microvessel-density-is-an-independent-survival-prognostic-factor-for-patients-with-hbv-related-hepatocellular-carcinoma
#17
Weiwei Yan, Zhenyu Zhu, Fei Pan, Ang Huang, Guang-Hai Dai
Background: To explore new biomarkers for indicating the recurrence and prognosis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients after tumor resection, we investigated the expression and prognostic value of c-kit(CD117) in HBV-related HCC. Materials and methods: Immunohistochemistry was used to estimate the expression of c-kit(CD117) and CD34 in the liver cancer tissues. The correlations between the expression of these biomarkers and the clinicopathologic characteristics were analyzed...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29561452/preoperative-platelet-albumin-bilirubin-grades-predict-the-prognosis-of-patients-with-hepatitis-b-virus-related-hepatocellular-carcinoma-after-liver-resection-a-retrospective-study
#18
Hong-Mei Luo, Shu-Zhen Zhao, Chuan Li, Li-Ping Chen
Minimal information is available concerning platelet-albumin-bilirubin (PALBI) grades in patients with hepatocellular carcinoma (HCC) following liver resection. This study aimed to investigate the predictive ability of PALBI grades in patients with a Child-Pugh class A score and hepatitis B virus-related (HBV-related) HCC after liver resection.The data of patients with HBV-related HCC who underwent liver resection from 2010 to 2017 at our center were reviewed (n = 785). Cox regression was used to determine factors independently associated with postoperative recurrence and mortality...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29560652/sorafenib-induced-hepatic-encephalopathy
#19
S S Sidhu, S Agarwal, O Goyal, H Kishore, S Sidhu
A 60 year old male, known case of Hepatitis C related cirrhosis was diagnosed with exophytic Hepatocellular carcinoma (size 2.1 x 2.2 cm), Barcelona Clinic Liver Cancer Stage A, on routine surveillance. He refused liver Transplant and underwent laparoscopic segmental resection. Thereafter patient was started on Tablet Sorafenib 400mg twice daily to prevent recurrence of Hepatocellular carcinoma. On 18st post-operative day, patient presented with Hepatic encephalopathy. Routine investigations and MRI Brain were normal; Venous ammonia was high...
October 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29536209/right-trisectionectomy-and-caval-reconstruction-with-peritoneal-patch-under-short-total-vascular-exclusion-for-hepatocellular-carcinoma-with-tumoral-thrombus-in-suprahepatic-vena-cava
#20
Safi Dokmak, Béatrice Aussilhou, Tiziana Marchese, Nizar Kardoun, François Cauchy, Anne Sophie Schneck, Olivier Soubrane
BACKGROUND: Hepatocellular carcinoma (HCC) can be complicated by major vascular invasion, and resection can be beneficial in some patients.1 Some of these patients are traditionally operated under total vascular exclusion (TVE), refrigeration, extracorporeal circulatory bypass, and cardiac surgery, with high morbidity and mortality.2 However, HCC thrombi are not adherent to the venous wall, and with advances in surgical techniques, resection can be simplified and performed during short-duration TVE alone...
May 2018: Annals of Surgical Oncology
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