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https://www.readbyqxmd.com/read/28938451/antibody-mediated-targeting-of-the-fgfr1c-isoform-increases-glucose-uptake-in-white-and-brown-adipose-tissue-in-male-mice
#1
Jo E Lewis, Ricardo J Samms, Scott Cooper, Jeni C Luckett, Alan C Perkins, James D Dunbar, Dennis P Smith, Paul J Emmerson, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growth factor receptor 1c isoform (FGFR1c) has been shown to ameliorate hyperglycaemia and protect from diet- and genetically-induced obesity in rodents and non-human primates. However, it is currently unknown which tissue(s) contribute to this glucose lowering effect...
August 16, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938330/temporal-scalp-thickness-body-mass-index-and-suprafascial-placement-of-receiver-coil-of-the-cochlear-implant
#2
Orhan Ozturan, Alper Yenigun, Erol Senturk, Omer Faruk Calim, Fadlullah Aksoy, Sabri Baki Eren
OBJECTIVE: The objectives of this study are to demonstrate the relationship between the thickness of the temporal scalp and body mass index (BMI), age, and sex, and to present the surgical technique which we perform in patients with a thick scalp. MATERIALS AND METHODS: This is a retrospective, cross-sectional study. This study was performed in a tertiary referral center. Cranial computed tomography images of 469 subjects were included in the study. These subjects were evaluated according to BMI, age, and sex...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28933236/evaluating-the-contribution-of-lower-extremity-kinetics-to-whole-body-power-output-during-the-power-snatch
#3
Sangwoo Lee, Kyle D DeRosia, Landon M Lamie
This study evaluated the contribution of lower extremity (hip, knee and ankle) net joint torques (NJT) to whole body power (WBP) output during the power snatch (PS). Ten experienced weightlifters (five males and five females) performed five trials of the PS with 60% of one repetition maximum. Lower extremity NJT and WBP were extracted through a three-dimensional motion analyses and used for data analyses. Pearson correlation coefficients were obtained to observe the relationship between lower extremity NJT and WBP...
September 21, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28932987/effects-of-hand-configuration-on-muscle-force-coordination-co-contraction-and-concomitant-intermuscular-coupling-during-maximal-isometric-flexion-of-the-fingers
#4
Camille Charissou, David Amarantini, Robin Baurès, Eric Berton, Laurent Vigouroux
PURPOSE: The mechanisms governing the control of musculoskeletal redundancy remain to be fully understood. The hand is highly redundant, and shows different functional role of extensors according to its configuration for a same functional task of finger flexion. Through intermuscular coherence analysis combined with hand musculoskeletal modelling during maximal isometric hand contractions, our aim was to better understand the neural mechanisms underlying the control of muscle force coordination and agonist-antagonist co-contraction...
September 20, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28932609/neuromyelitis-optica-in-a-nepalese-man
#5
Yogesh Subedi, Utsav Joshi, Sanjeeb Sudarshan Bhandari, Ashbina Pokharel, Ashbita Pokharel
BACKGROUND: Neuromyelitis optica is a severely disabling inflammatory disorder of the central nervous system of autoimmune etiology that mainly affects the optic nerves and spinal cord. Here, we present a case report detailing a patient with tingling and weakness of right upper and lower limbs who was neuromyelitis optica immunoglobulin G-positive. CASE PRESENTATION: A 46-year-old Nepalese man presented to the hospital with a history of tingling and weakness of right upper and lower limbs that developed over a period of two months...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28931652/responsive-monitoring-of-mitochondrial-redox-states-in-heart-muscle-predicts-impending-cardiac-arrest
#6
Dorothy A Perry, Joshua W Salvin, Padraic Romfh, Peili Chen, Kalyani Krishnamurthy, Lindsay M Thomson, Brian D Polizzotti, Francis X McGowan, Daryoosh Vakhshoori, John N Kheir
Assessing the adequacy of oxygen delivery to tissues is vital, particularly in the fields of intensive care medicine and surgery. As oxygen delivery to a cell becomes deficient, changes in mitochondrial redox state precede changes in cellular function. We describe a technique for the continuous monitoring of the mitochondrial redox state on the epicardial surface using resonance Raman spectroscopy. We quantify the reduced fraction of specific electron transport chain cytochromes, a metric we name the resonance Raman reduced mitochondrial ratio (3RMR)...
September 20, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28930877/the-impact-of-exercise-induced-muscle-damage-on-performance-test-outcomes-in-elite-female-basketball-players
#7
Kenji Doma, Anthony Leicht, Wade Sinclair, Moritz Schumann, Felipe Damas, Dean Burt, Carl Woods
The purpose of this study was two-fold. First, to examine the impact exercise-induced muscle damage (EIMD) on physical fitness qualities following a basketball-specific training session. Secondly, to determine the reproducibility of the sport-specific performance measures in elite female basketball players. Ten elite female basketball players (age 25.6 ± 4.5 years; height 1.8 ± 0.7m; body mass 76.7 ± 8.3kg) undertook a 90-minute training session involving repeated jumping, sprinting and game-simulated training...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930275/anti-aging-and-antioxidant-potential-of-paullinia-cupana-var-sorbilis-findings-in-caenorhabditis-elegans-indicate-a-new-utilization-for-roasted-seeds-of-guarana
#8
Herbenya Peixoto, Mariana Roxo, Teresa Röhrig, Elke Richling, Xiaojuan Wang, Michael Wink
Background: Roasted seeds of Amazonian guarana (Paullinia cupana var. sorbilis; Sapindaceae) are popular in South America due to their stimulant activity on the central nervous system (CNS). Rich in purine alkaloids, markedly caffeine, the seeds are extensively used in the Brazilian beverage industry for the preparation of soft drinks and as additives in energy drinks. Methods: To investigate the putative anti-aging and antioxidant activity of guarana, we used the model organism Caenorhabditis elegans. Chemical analyses were performed using high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS/MS)...
August 15, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28927901/age-related-reductions-in-muscle-quality-influence-the-relative-differences-in-strength-and-power
#9
Gena R Gerstner, Hayden K Giuliani, Jacob A Mota, Eric D Ryan
Age-related changes in the relative differences in isokinetic strength and power may reflect fast twitch fiber function. We aimed to examine the influence of muscle quality on the relative differences in strength and power in younger and older men. Twenty younger (20.1±1.5yrs) and 20 older (69.5±3.1yrs) healthy, recreationally active men performed two plantarflexion maximal voluntary isometric contractions (MVCs) and three maximal concentric isokinetic contractions at a slow (0.52rad·s(-1)) and fast (2.09rad·s(-1)) velocity...
September 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28923171/potential-early-biomarkers-of-sarcopenia-among-independent-older-adults
#10
Ana Coto Montes, José Antonio Boga, Carlos Bermejo Millo, Adrián Rubio González, Yaiza Potes Ochoa, Ignacio Vega Naredo, Marta Martínez Reig, Luis Romero Rizos, Pedro Manuel Sánchez Jurado, Juan Jose Solano, Pedro Abizanda, Beatriz Caballero
OBJECTIVES: There are no tools or biomarkers for a quantitative analysis of sarcopenia. STUDY DESIGN: Cross-sectional study of the diagnosis of sarcopenia in 200 independent adults aged 70 years or over. MAIN OUTCOME MEASURES: Sarcopenia was defined as loss of muscle mass together with low strength and/or loss of physical performance. We considered different clinical parameters and assayed potential blood biomarkers (cell energetic metabolism, muscle performance, inflammation, infection and oxidative stress)...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28918950/power-transfer-to-a-human-during-an-electric-eel-s-shocking-leap
#11
Kenneth C Catania
Electric eels have been the subject of investigation and curiosity for centuries [1]. They use high voltage to track [2] and control [3] prey, as well as to exhaust prey by causing involuntary fatigue through remote activation of prey muscles [4]. But their most astonishing behavior is the leaping attack, during which eels emerge from the water to directly electrify a threat [5, 6]. This unique defense has reportedly been used against both horses [7] and humans [8]. Yet the dynamics of the circuit that develops when a living animal is contacted and the electrical power transmitted to the target have not been directly investigated...
September 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28918356/what-is-the-price-for-the-duchenne-gait-pattern-in-patients-with-cerebral-palsy
#12
Firooz Salami, Mirjam Niklasch, Britta K Krautwurst, Thomas Dreher, Sebastian I Wolf
Duchenne gait is characterized by trunk lean towards the affected stance limb with the pelvis stable or elevated on the swinging limb side during single limb stance phase. We assessed the relationship between hip abduction moments and trunk kinetics in patients with cerebral palsy showing excessive lateral trunk motion. Data of 18 subjects with bilateral spastic cerebral palsy (CP) and 20 aged matched typically developing subjects (TD) were collected retrospectively. Criteria for patient selection were barefoot walking without aid presenting with excessive lateral trunk motion...
September 7, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28918167/different-nutritional-assessment-tools-as-predictors-of-postoperative-complications-in-patients-undergoing-colorectal-cancer-resection
#13
Sílvia Fernandes Maurício, Jingjie Xiao, Carla M Prado, Maria Cristina Gonzalez, Maria Isabel Toulson Davisson Correia
BACKGROUND & AIMS: Malnutrition in patients with colorectal cancer contributes to increased postoperative complications. The aim of the study was to evaluate the prognostic value of several nutritional assessment parameters: body mass index versus percentage of weight loss grading system (BMI/%WL); Patient-Generated Subjective Global Assessment (PG-SGA); standardized phase angle (SPA) by BIA; muscle strength by handgrip strength; muscle mass by computerized tomography; and the combination of muscle mass and strength in patients undergoing resection surgery...
September 4, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28917695/the-impact-of-gabaergic-drugs-on-tms-induced-brain-oscillations-in-human-motor-cortex
#14
Isabella Premoli, Til O Bergmann, Matteo Fecchio, Mario Rosanova, Andrea Biondi, Paolo Belardinelli, Ulf Ziemann
Brain responses to transcranial magnetic stimulation (TMS) as measured with electroencephalography (EEG) have so far been assessed either by TMS-evoked EEG potentials (TEPs), mostly reflecting phase-locked neuronal activity, or time-frequency-representations (TFRs), reflecting oscillatory power arising from a mixture of both evoked (i.e., phase-locked) and induced (i.e., non-phase-locked) responses. Single-pulse TMS of the human primary motor cortex induces a specific pattern of oscillatory changes, characterized by an early (30-200 ms after TMS) synchronization in the α- and β-bands over the stimulated sensorimotor cortex and adjacent lateral frontal cortex, followed by a late (200-400 ms) α- and β-desynchronization over the stimulated and contralateral sensorimotor cortex...
September 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28914711/change-in-eyelid-position-following-muller-s-muscle-conjunctival-resection-with-a-standard-versus-variable-resection-length
#15
Daniel B Rootman, Kunal R Sinha, Robert A Goldberg
PURPOSE: This study compares the use of a standard 7 mm resection length to a variable 4:1 ratio of resection length to desired elevation nomogram when performing Muller's muscle conjunctival resection surgery. METHODS: In this cross-sectional case control study, 2 groups were defined. The first underwent Muller's muscle conjunctival resection surgery with a standard 7 mm resection length and the second underwent the same surgery with a variable resection length determined by a 4:1 ratio of resection length to desired elevation nomogram...
September 12, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28914503/testosterone-therapy-preserves-muscle-strength-and-power-in-aging-men-with-type-2-diabetes-a-randomized-controlled-trial
#16
L V Magnussen, L G Hvid, A P Hermann, D M Hougaard, B Gram, P Caserotti, M S Andersen
The purpose of the study was to evaluate whether testosterone replacement therapy improves muscle mechanical and physical function in addition to increasing lean leg mass and total lean body mass in aging men with type 2 diabetes and lowered bio-available testosterone (BioT) levels. Thirty-nine men aged 50-70 years with type 2 diabetes and BioT levels <7.3 nmol/L were included from an academic tertiary-care medical center. Patients were randomized to testosterone gel (testosterone replacement therapy, n = 20) or placebo (n = 19) for 24 weeks, applying a double-blinded design...
September 2017: Andrology
https://www.readbyqxmd.com/read/28914463/burrowing-with-a-kinetic-snout-in-a-snake-elapidae-aspidelaps-scutatus
#17
Alexandra Deufel
Of the few elongate, fossorial vertebrates that have been examined for their burrowing mechanics, all were found to use an akinetic, reinforced skull to push into the soil, powered mostly by trunk muscles. Reinforced skulls were considered essential for head-first burrowing. In contrast, I found that the skull of the fossorial shield-nosed cobra (Aspidelaps scutatus) is not reinforced and retains the kinetic potential typical of many non-fossorial snakes. Aspidelaps scutatus burrows using a greatly enlarged rostral scale that is attached to a kinetic snout that is independently mobile with respect to the rest of the skull...
September 15, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28913560/deregulation-of-obesity-relevant-genes-is-associated-with-progression-in-bmi-and-the-amount-of-adipose-tissue-in-pigs
#18
Caroline M Junker Mentzel, Tainã Figueiredo Cardoso, Christian Bressen Pipper, Mette Juul Jacobsen, Claus Bøttcher Jørgensen, Susanna Cirera, Merete Fredholm
The aim of this study was to elucidate the relative impact of three phenotypes often used to characterize obesity on perturbation of molecular pathways involved in obesity. The three obesity-related phenotypes are (1) body mass index (BMI), (2) amount of subcutaneous adipose tissue (SATa), and (3) amount of retroperitoneal adipose tissue (RPATa). Although it is generally accepted that increasing amount of RPATa is 'unhealthy', a direct comparison of the relative impact of the three obesity-related phenotypes on gene expression has, to our knowledge, not been performed previously...
September 14, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28912943/assessment-of-low-level-laser-therapy-effects-after-extraction-of-impacted-lower-third-molar-surgery
#19
Shahrokh Raiesian, Mehdi Khani, Kazem Khiabani, Ershad Hemmati, Mohammad Pouretezad
Introduction: The aim of this study was to assess the effect of low-level laser therapy (LLLT) on pain, swelling and maximum mouth opening in patients undergoing third molar surgery. Methods: A prospective, randomized double-blind study was undertaken on 44 patients at the Dental School, Ahvaz Jundishapur University of Medical Sciences, in 2015. A low-level laser was randomly applied on one of the two sides after surgery of 15 patients. The experimental side received 18 J/cm(2) of energy density, wavelength of 980 nm, and output power of 1...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/28912726/cardiovascular-and-muscular-consequences-of-work-matched-interval-type-of-concentric-and-eccentric-pedaling-exercise-on-a-soft-robot
#20
Martin Flück, Rebekka Bosshard, Max Lungarella
Eccentric types of endurance exercise are an acknowledged alternative to conventional concentric types of exercise rehabilitation for the cardiac patient, because they reduce cardiorespiratory strain due to a lower metabolic cost of producing an equivalent mechanical output. The former contention has not been tested in a power- and work-matched situation of interval-type exercise under identical conditions because concentric and eccentric types of exercise pose specific demands on the exercise machinery, which are not fulfilled in current practice...
2017: Frontiers in Physiology
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