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https://www.readbyqxmd.com/read/28717270/antioxidant-therapy-in-idiopathic-oligoasthenoteratozoospermia
#1
REVIEW
Ahmad Majzoub, Ashok Agarwal
INTRODUCTION: Idiopathic oligoasthenoteratozoospermia (iOAT) is commonly encountered during the evaluation of men with infertility. Antioxidants have been utilized empirically in the treatment of iOAT based on their ability to reverse oxidative stress (OS)-induced sperm dysfunction often encountered in this patient population. METHODS: A literature search was performed using MEDLINE/PubMed, focusing on publications of antioxidant therapies for iOAT. The main objective of our review article was to report the rationale and available evidence supporting the use of antioxidants...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28715732/proteasome-inhibitor-induced-cleavage-of-hsp90-is-mediated-by-ros-generation-and-caspase-10-activation-in-human-leukemic-cells
#2
Sangkyu Park, Jeong-A Park, Hwanmin Yoo, Han-Bum Park, Younghee Lee
Heat shock protein 90 (HSP90) is a molecular chaperone that supports the stability of client proteins. The proteasome is one of the targets for cancer therapy, and studies are underway to use proteasome inhibitors as anti-cancer drugs. In this study, we found that HSP90 was cleaved to a 55kDa protein after treatment with proteasome inhibitors including MG132 in leukemia cells but was not cleaved in other tissue-derived cells. HSP90 has two major isoforms (HSP90α and HSP90β), and both were cleaved by MG132 treatment...
July 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28715154/the-role-of-oxidative-stress-in-acute-renal-injury-of-newborn-rats-exposed-to-hypoxia-and-endotoxin
#3
Egor Y Plotnikov, Tatiana A Pavlenko, Irina B Pevzner, Ljubava D Zorova, Vasily N Manskikh, Denis N Silachev, Gennady T Sukhikh, Dmitry B Zorov
Neonatal kidney injury is a frequent pathology, especially among premature infants. The search for effective nephroprotection requires the creation of adequate experimental models of nephropathy in newborns. In this study, we explored the development of acute kidney injury (AKI) in neonatal rats during hypoxia or administration of endotoxin. We found that 2-h hypoxia (8% O2 ) and the intraperitoneal injection of 4 mg/kg lipopolysaccharide (LPS) causes the appearance of AKI markers, such as КIM-1 and NGAL in the rat urine after 24 and 72 h of exposure...
July 17, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28714083/acute-liver-failure-with-amiodarone-infusion-a-case-report-and-systematic-review
#4
P Jaiswal, B M Attar, J E Yap, K Devani, R Jaiswal, Y Wang, R Szynkarek, D Patel, M Demetria
WHAT IS KNOWN AND OBJECTIVE: Amiodarone, a commonly used class III antiarrhythmic agent notable for a relatively long half-life of up to 6 months and its pronounced adverse effect profile, is used for both acute and chronic management of cardiac arrhythmias. Chronic use of amiodarone has been associated with asymptomatic hepatotoxicity; however, acute toxicity is thought to be uncommon. There are only six reported cases of acute liver failure (ALF) secondary to amiodarone. In all these cases the outcome of death during the same hospitalization resulted...
July 16, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28712479/antiplatelet-aggregation-activity-of-walnut-hull-extract-via-suppression-of-reactive-oxygen-species-generation-and-caspase-activation
#5
Azadeh Meshkini, Masoumeh Tahmasbi
Walnut hull (wal hull) is an agricultural by-product that is widely used in traditional medicine for alleviating pain and treating skin diseases, however, recently it has gained much attention in modern pharmacology due to its antioxidant properties. The current study was aimed to determine the total phenolic, flavonoid, and tannin content of Persian wal hull extract and evaluate its biological effects on platelet function. Experimental data showed that acetone extract of wal hulls has a high content of polyphenolic compounds and antioxidant properties...
June 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28711906/oxidative-stress-mediates-an-increased-formation-of-vascular-endothelial-growth-factor-in-human-hepatocarcinoma-cells-exposed-to-erlotinib
#6
Nataliya Rohr-Udilova, Florian Klinglmüller, Martha Seif, Hubert Hayden, Martin Bilban, Matthias Pinter, Klaus Stolze, Wolfgang Sieghart, Markus Peck-Radosavljevic, Michael Trauner
The tyrosine kinase inhibitor erlotinib targets the receptor of epidermal growth factor (EGFR) involved in development of hepatocellular carcinoma (HCC). Although inefficient in established HCC, erlotinib has been recently proposed for HCC chemoprevention. Since Cyp3A4 and Cyp1A2 enzymes metabolize erlotinib in the liver, the insights into the mechanisms of erlotinib effects on liver cells with maintained drug metabolizing activity are needed. We applied erlotinib to both commercially available (SNU398, Huh7) and established in Austria HCC cell lines (HCC-1...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28711811/n-acetylcysteine-reduces-cocaine-cue-attentional-bias-and-differentially-alters-cocaine-self-administration-based-on-dosing-order
#7
B L Bolin, Joseph L Alcorn, Joshua A Lile, Craig R Rush, Abner O Rayapati, Lon R Hays, William W Stoops
BACKGROUND: Disrupted glutamate homeostasis is thought to contribute to cocaine-use disorder, in particular, by enhancing the incentive salience of cocaine stimuli. n-Acetylcysteine might be useful in cocaine-use disorder by normalizing glutamate function. In prior studies, n-acetylcysteine blocked the reinstatement of cocaine seeking in laboratory animals and reduced the salience of cocaine stimuli and delayed relapse in humans. METHODS: The present study determined the ability of maintenance on n-acetylcysteine (0 or 2400mg/day, counterbalanced) to reduce the incentive salience of cocaine stimuli, as measured by an attentional bias task, and attenuate intranasal cocaine self-administration (0, 30, and 60mg)...
June 29, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28710607/evaluation-of-a-food-and-drug-administration-mandate-to-limit-acetaminophen-in-prescription-combination-products
#8
David Goldberger, David Vearrier
INTRODUCTION: In 2014, the US Food and Drug Administration limited the production of prescription acetaminophen-opioid combination products to 325 mg per dose unit. The goal of this mandate was to decrease the likelihood of unintentional acetaminophen hepatotoxicity. This study was designed to determine if this federal regulation has succeeded in reducing unintentional acetaminophen-induced hepatotoxicity from opioid combination products. METHODS: Using data from the National Poison Data System (NPDS), we analyzed all calls to US Poison Control Centers in the years 2013 and 2015 for acetaminophen-opioid combination product exposures...
July 14, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28710022/taxifolin-reduces-the-cholesterol-oxidation-product-induced-neuronal-apoptosis-by-suppressing-the-akt-and-nf-%C3%AE%C2%BAb-activation-mediated-cell-death
#9
Arum Kim, Yoon Jeong Nam, Chung Soo Lee
The taxifolin effect on the cholesterol oxidation product-induced neuronal apoptosis was investigated using differentiated PC12 cells and human neuroblastoma SH-SY5Y cells. 7-ketocholesterol induced phosphorylation of Akt, and increase in the levels of cytosolic and nuclear NF-κB p65, cytosolic NF-κB p50 and cytosolic phosphorylated-IκB-α in PC12 cells. The cholesterol oxidation products also induced a decrease in the levels of Bid and Bcl-2, increase in the levels of p53 and Bax, loss of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases (-8, -9 and -3), production of reactive oxygen species, depletion of GSH and cell death in both cell lines...
July 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28708700/n-acetylcysteine-for-acute-hepatitis-induced-by-kratom-herbal-tea
#10
Mina S Mousa, Andrew Sephien, Juliana Gutierrez, Charlotte OʼLeary
No abstract text is available yet for this article.
July 6, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28706483/phytoagent-deoxyelephantopin-and-its-derivative-inhibit-triple-negative-breast-cancer-cell-activity-through-ros-mediated-exosomal-activity-and-protein-functions
#11
Jeng-Yuan Shiau, Yong-Qun Chang, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur
A novel plant sesquiterpene lactone derivative, DET derivative (DETD)-35, originating from parental deoxyelephantopin (DET) was previously observed to effectively suppress human triple negative breast cancer (TNBC) MDA-MB-231 cell activity and tumor growth in mice. In this study, the mechanisms underlying the activity of DETD-35 were elucidated. DET and DETD-35 induced reactive oxygen species (ROS) which caused structural damage and dysfunction of mitochondria and increased cytosolic calcium level, subsequently evoking exosome release from the cancer cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28706398/efficacy-of-atorvastatin-in-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-angiography-a-double-blind-randomized-controlled-trial
#12
Maaz Hussain Syed, Prakash Narayan Khandelwal, Vijay R Thawani, S S Katare
OBJECTIVE: To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the prevention of contrast medium- induced nephropathy (CIN) in high risk patients undergoing angiograph. MATERIALS AND METHODS: This was a prospective, double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing coronary angiography were screened, and 188 eligible patients were randomized to two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC) 1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg + NAC 1200 mg once daily, for 3 days before, and 2 days after angiography...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28703941/determination-of-the-absolute-configuration-of-hydroxynitrilaphos-and-related-biosynthetic-questions
#13
Katharina Pallitsch, Barbara Happl, Christian Stieger
The ongoing search for bioactive natural products led to the development of new genome-based screening approaches to identify possible phosphonate producing microorganisms. From the identified phosphonate producers, several until now unknown phosphonic acid natural products were isolated, including (hydroxy)nitrilaphos (4 and 5) and (hydroxy)phosphonocystoximate (7 and 6). We present the synthesis of phosphonocystoximate via an aldoxime intermediate. Chlorination and coupling with methyl N-acetylcysteinate furnished 6 after global deprotection...
July 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28701243/regulation-of-fetuin-a-gene-expression-in-the-neonatal-pig-liver
#14
T G Ramsay, M J Stoll, L A Blomberg, T J Caperna
Fetuin A (also known as α2-Heremans-Schmid glycoprotein) is a protein primarily expressed by the liver and secreted into the blood. Previous studies have suggested that plasma concentrations of fetuin A are elevated with impaired growth rate in swine. The present study was designed to examine the relationship of porcine fetuin A with growth rate in the pig and to also elucidate the regulation of fetuin A expression by examining the hormonal and cytokine regulation of fetuin A mRNA abundance in hepatocytes prepared from suckling piglets...
July 13, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28696247/microrna-92a-mediates-endothelial-dysfunction-in-ckd
#15
Fenqing Shang, Shen-Chih Wang, Chien-Yi Hsu, Yifei Miao, Marcy Martin, Yanjun Yin, Chih-Cheng Wu, Yun-Ting Wang, Gaihong Wu, Shu Chien, Hsien-Da Huang, Der-Cherng Tarng, Yan-Ting Shiu, Alfred K Cheung, Po-Hsun Huang, Zhen Chen, John Y-J Shyy
CKD is an independent risk factor for cardiovascular disease (CVD). The accumulation of uremic toxins in CKD induces oxidative stress and endothelial dysfunction. MicroRNA-92a (miR-92a) is induced by oxidative stress in endothelial cells (ECs) and involved in angiogenesis and atherosclerosis. We investigated a role for oxidative stress-responsive miR-92a in CKD. Our study of patients at three clinical sites showed increased serum miR-92a level with decreased kidney function. In cultured ECs, human CKD serum or uremic toxins (such as indoxyl sulfate), compared with non-CKD serum, induced the levels of miR-92a and suppressed the expression of miR-92a targets, including key endothelial-protective molecules...
July 10, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28691995/the-role-of-psychological-stress-on-heart-autophagy-in-mice-with-heart-failure
#16
Xiao-Ting Lu, Xiao-Qiong Liu, Bo Wang, Yuan-Yuan Sun, Rui-Xue Yang, Yi-Fan Xing, Ping Sun, Ying-Bin Wang, Yu-Xia Zhao
OBJECTIVE: Psychological stress in chronic heart failure (CHF) is associated with systemic neurohormonal and immune system responses and increased mortality. Autophagy refers to the biological process of degradation and recycling of dysfunctional cellular components. We investigated the role of psychological stress on autophagy function in CHF mice. RESULTS: A one-week stress exposure significantly increased serum levels of corticosterone and Ang II (P= .000), increased levels of oxidative stress, induced overt heart failure, and increased mortality (P =...
July 7, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28691804/toxicity-of-wastewater-with-elevated-bromide-and-iodide-after-chlorination-chloramination-or-ozonation-disinfection
#17
Shengkun Dong, Nedal Massalha, Michael J Plewa, Thanh H Nguyen
Water reuse is receiving unprecedented attention, as many areas around the globe attempt to better manage their fresh water resources. Wastewaters in coastal regions may contain elevated levels of bromide (Br-) and iodide (I-) from seawater intrusion or a high mineral content in the source waters. Disinfection of such wastewater is essential to prevent the spread of pathogens, however, little is known about the toxicity of the treated wastewater. In this study, we evaluated the genotoxicity to Chinese Hamster Ovary (CHO) cells induced by municipal secondary wastewater effluent amended with elevated Br-/I- after disinfection by chlorine, chloramines, or ozone...
July 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28690887/prevention-of-%C3%AE-radiation-induced-dna-damage-in-human-lymphocytes-using-a-serine-magnesium-sulfate-mixture
#18
Vahid Changizi, Mona Bahrami, Mahbod Esfahani, Seyed V Shetab-Boushehri
OBJECTIVES: Ionising radiation has deleterious effects on human cells. N-acetylcysteine (NAC) and cysteine, the active metabolite of NAC, are well-known radioprotective agents. Recently, a serine-magnesium sulfate combination was proposed as an antidote for organophosphate toxicity. This study aimed to investigate the use of a serine-magnesium sulfate mixture in the prevention of γ-radiation-induced DNA damage in human lymphocytes as compared to NAC and cysteine. METHODS: This study was carried out at the Iran University of Medical Sciences, Tehran, Iran, between April and September 2016...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28687021/insulin-resistance-in-vitamin-d-deficient-mice-is-alleviated-by-n-acetylcysteine
#19
Zhao-Hui Cui, Qi Yuan, Li Mao, Feng-Li Chen, Feng Ji, Sha Tao
Vitamin D deficiency will lead to insulin resistance. In the current study, vitamin D3 1α-Hydroxylase ["1α(OH)ase"] knockout mice were generated to mimic vitamin D deficiency in vivo. As compared to the wild-type mice, the liver tissues of the knockout mice showed impaired insulin signaling, decreased glucose transporter 4 expression and increased reactive oxygen species production. Meanwhile, p53-p21 activation, apoptosis intensity and pro-inflammatory cytokines (IL-6, IL-1 and MIP-1α) level were significantly increased in the knockout mice livers...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28687018/vitamin-d-deficiency-causes-insulin-resistance-by-provoking-oxidative-stress-in-hepatocytes
#20
Sha Tao, Qi Yuan, Li Mao, Feng-Li Chen, Feng Ji, Zhao-Hui Cui
Vitamin D deficiency could cause insulin resistance. However, the underlying mechanisms are unclear. The 1α-Hydroxylase ["1α(OH)ase"] is a key enzyme for activate vitamin D3 synthesis. Here, we show that 1α(OH)ase stable knockdown by targeted shRNA led to vitamin D3 depletion in L02 hepatocytes. 1α(OH)ase silence also inhibited insulin-induced downstream signaling (IRS-1, ERK and AKT) transduction and glucose transporter 4 expression. Further, 1α(OH)ase shRNA in L02 hepatocytes led to significant reactive oxygen species production, p53-p21 activation and DNA damages...
June 28, 2017: Oncotarget
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