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https://www.readbyqxmd.com/read/28632725/the-role-of-primary-tumour-sidedness-egfr-gene-copy-number-and-egfr-promoter-methylation-in-ras-braf-wild-type-colorectal-cancer-patients-receiving-irinotecan-cetuximab
#1
Laura Demurtas, Marco Puzzoni, Riccardo Giampieri, Pina Ziranu, Valeria Pusceddu, Alessandra Mandolesi, Chiara Cremolini, Gianluca Masi, Fabio Gelsomino, Carlotta Antoniotti, Cristian Loretelli, Fausto Meriggi, Alberto Zaniboni, Alfredo Falcone, Stefano Cascinu, Mario Scartozzi
BACKGROUND: The data from randomised trials suggested that primary tumour sidedness could represent a prognostic and predictive factor in colorectal cancer (CRC) patients, particularly during treatment with anti-epidermal growth factor receptor (EGFR) therapy. However, an in-deep molecular selection might overcome the predictive role of primary tumour location in this setting. METHODS: We conducted a retrospective analysis in which tumour samples from RAS/BRAF wild-type (WT) metastatic CRC patients treated with second-third-line irinotecan/cetuximab were analysed for EGFR gene copy number (GCN) and promoter methylation...
June 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28627486/the-association-between-detected-drug-resistance-mutations-and-cd4-t-cell-decline-in-hiv-positive-individuals-maintained-on-a-failing-treatment-regimen
#2
Anna Schultze, Roger Paredes, Caroline Sabin, Andrew N Phillips, Deenan Pillay, Nicola Mackie, Antonella Castagna, David Chadwick, Karolin Falconer, Anna Maria Geretti, Frank A Post, Teresa Hill, Ole Kirk, Anton Pozniak, Mark Nelson, Anna Tostevin, David Dunn, Jens Lundgren, Alessandro Cozzi-Lepri
BACKGROUND: To analyse the effect of drug resistance mutations (DRM) on CD4 cell trends in HIV-positive people maintained on virologically failing antiretroviral therapy (ART). METHODS: Individuals from two large cohorts experiencing virological failure (VF) while maintained on ART with >1 CD4 count and >1 resistance test were included. CD4 cell slopes were estimated using linear mixed models. Principal component analysis (PCA) was used to assess the effect of clusters of mutations, defined using extracted component based scores from the PCA, on CD4 cell decline...
June 19, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28626458/corrigendum-identification-of-rare-pb2-d701n-mutation-from-a-patient-with-severe-influenza-contribution-of-the-pb2-d701n-mutation-to-the-pathogenicity-of-human-influenza
#3
Amelia Nieto, Francisco Pozo, Matxalen Vidal-García, Manuel Omeñaca, Inmaculada Casas, Ana Falcón
[This corrects the article on p. 575 in vol. 8, PMID: 28421062.].
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28623768/general-health-questionnaire-12-validity-in-colombia-and-factorial-equivalence-between-clinical-and-nonclinical-participants
#4
Francisco J Ruiz, Diana M García-Beltrán, Juan C Suárez-Falcón
The General Health Questionnaire - 12 (GHQ-12) is a widely used screening self-report for emotional disorders among adults. However, there is little evidence concerning the validity of the GHQ-12 in Colombia and its factorial invariance between nonclinical and clinical samples. Accordingly, the current study aims to explore the GHQ-12 validity in Colombian nonclinical and clinical samples. The GHQ-12 was administered to a total of 1641 participants, including a sample of undergraduates, one of general population, and a clinical sample...
June 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28621440/t-lymphocytes-dominate-local-leukocyte-infiltration-in-response-to-intradermal-injection-of-functionalized-graphene-based-nanomaterial
#5
G F Erf, D M Falcon, K S Sullivan, S E Bourdo
Graphene-based nanomaterials (GBN) have many potential biomedical applications. However, information regarding their biological properties and interactions with cells and/or soluble factors within a complex tissue is limited. The objective of this study was to use the growing feather (GF) of chickens as a minimally invasive cutaneous test-site to assess and monitor leukocyte recruitment in response to intradermal GBN injection. Specifically, the dermis of 20 GFs per chicken was injected with 10 μl of phosphate-buffered saline (PBS)-vehicle or 10 μl of 300 μg ml(-1) oxygen-functionalized (f) GBN (6 chickens/treatment)...
June 16, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28620961/normal-atxn2-alleles-influences-on-the-age-at-onset-in-spinocerebellar-ataxia-type-2
#6
REVIEW
Luis E Almaguer-Mederos, Raúl Aguilera-Rodríguez, Dany Cuello-Almarales, Dennis Almaguer-Gotay, Yanetza González-Zaldívar, Yaimé Vázquez-Mojena, Nieves Santos-Falcón, Gilberto Sánchez-Cruz, Luis Velázquez-Pérez
No abstract text is available yet for this article.
June 16, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28620612/potential-role-of-pet-cats-as-a-sentinel-species-for-human-exposure-to-flame-retardants
#7
Luis A Henríquez-Hernández, Elena Carretón, María Camacho, José Alberto Montoya-Alonso, Luis D Boada, Verónica Bernal Martín, Yaiza Falcón Cordón, Soraya Falcón Cordón, Manuel Zumbado, Octavio P Luzardo
Flame retardants are a wide group of chemicals used by the industry to avoid combustion of materials. These substances are commonly found in plastics, electronic equipment, fabrics, and in many other everyday articles. Subsequently, ubiquitous environmental contamination by these common chemical is frequently reported. In the present study, we have evaluated the level of exposure to polychlorinated biphenyls (PCBs), brominated diphenyl ethers (BDEs), and organophosphorous flame retardants (OPFRs) in pet cats through the analysis of their serum...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28614359/phenological-changes-in-bamboo-carbohydrates-explain-the-preference-for-culm-over-leaves-by-giant-pandas-ailuropoda-melanoleuca-during-spring
#8
Katrina K Knott, Amelia L Christian, Josephine F Falcone, Carrie K Vance, Laura L Bauer, George C Fahey, Andrew J Kouba
Seasonal changes in the foodscape force herbivores to select different plant species or plant parts to meet nutritional requirements. We examined whether the search for calorie-rich carbohydrates explained giant panda's selection for bamboo culm over leaves during spring. Leaves and culms were collected from four Phyllostachys bamboos (P. aurea, P. aureosulcata, P. glauca, and P. nuda) once per month over 18-27 months. Monthly changes in annual plant part nutrients were examined, and compared to seasonal foraging behaviors of captive giant pandas...
2017: PloS One
https://www.readbyqxmd.com/read/28613884/carbohydrate-polypeptide-contacts-in-the-antibody-receptor-cd16a-identified-through-solution-nmr-spectroscopy
#9
Ganesh P Subedi, Daniel J Falconer, Adam W Barb
Asparagine-linked carbohydrates (N-glycans) are a common modification of eukaryotic proteins that confer multiple properties including the essential stabilization of therapeutic monoclonal antibodies. Here we present a rapid and efficient strategy to identify N-glycans that contact polypeptide residues and apply the method to profile the five N-glycans attached to the human antibody receptor CD16A (Fc gamma receptor IIIA). Human embryonic kidney 293S cells expressed CD16A with [13CU]-labeled N-glycans using standard protein expression techniques and medium supplemented with 3 g/L [13CU]-glucose...
June 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/28613269/exploiting-cell-death-pathways-for-inducible-cell-elimination-to-modulate-graft-versus-host-disease
#10
REVIEW
Corey Falcon, Mustafa Al-Obaidi, Antonio Di Stasi
Hematopoietic stem cell transplantation is a potent form of immunotherapy, potentially life-saving for many malignant hematologic diseases. However, donor lymphocytes infused with the graft while exerting a graft versus malignancy effect can also cause potentially fatal graft versus host disease (GVHD). Our group has previously validated the inducible caspase-9 suicide gene in the haploidentical stem cell transplant setting, which proved successful in reversing signs and symptoms of GVHD within hours, using a non-therapeutic dimerizing agent...
June 14, 2017: Biomedicines
https://www.readbyqxmd.com/read/28612401/safety-and-effectiveness-of-collagenase-clostridium-histolyticum-cch-xiapex-%C3%A2-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#11
Amr Abdel Raheem, Marco Capece, Odunayo Kalejaiye, Tarek Abdel-Raheem, Marco Falcone, Mark Johnson, Oliver George Ralph, Giulio Garaffa, Andrew Nim Christopher, David John Ralph
OBJECTIVES: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH) (Xiapex(®) , Xiaflex(®) ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol which aims at reducing the number of injections needed and reducing patient visits, thus reducing the cost and duration of treatment. PATIENTS AND METHODS: A prospective study of 53 patients with PD who had treatment with CCH at a single center using a new modified protocol...
June 14, 2017: BJU International
https://www.readbyqxmd.com/read/28601162/immature-and-mature-sperm-morphometry-in-fresh-and-frozen-thawed-falcon-ejaculates
#12
S Villaverde-Morcillo, A J Soler, M C Esteso, C Castaño, A Miñano-Berna, F Gonzalez, J Santiago-Moreno
Sperm morphometry is one characteristic which may be useful in prediction of fertility and sperm freezability in a species. Knowledge of the sperm characteristics of the ejaculate and the morphometric descriptors is necessary to effectively develop sperm cryopreservation. The aim of the current study was to provide a general description of the sperm from two falcon species (Peregrine falcon Falco peregrinus peregrinus/brookei and Gyrfalcon Falco rusticolus) including immature sperm, sperm head morphometric descriptors, and the existence of mature sperm subpopulations...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28599628/tribe-2-a-phase-iii-randomized-open-label-strategy-trial-in-unresectable-metastatic-colorectal-cancer-patients-by-the-gono-group
#13
Chiara Cremolini, Federica Marmorino, Fotios Loupakis, Gianluca Masi, Carlotta Antoniotti, Lisa Salvatore, Marta Schirripa, Luca Boni, Vittorina Zagonel, Sara Lonardi, Giuseppe Aprile, Emiliano Tamburini, Vincenzo Ricci, Monica Ronzoni, Filippo Pietrantonio, Chiara Valsuani, Gianluca Tomasello, Alessandro Passardi, Giacomo Allegrini, Samantha Di Donato, Daniele Santini, Alfredo Falcone
BACKGROUND: Chemotherapy plus bevacizumab is a standard first-line treatment for unresectable metastatic colorectal cancer patients. Different chemotherapy backbones may be chosen, including one to three drugs, based on patients' general conditions and comorbidities, treatments' objectives, and disease characteristics. TRIBE trial demonstrated a significant advantage in terms of progression-free survival and overall survival for FOLFOXIRI plus bevacizumab as compared with FOLFIRI plus bevacizumab...
June 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28599194/spatiotemporal-patterns-and-relationships-among-the-diet-biochemistry-and-exposure-to-flame-retardants-in-an-apex-avian-predator-the-peregrine-falcon
#14
Kim J Fernie, Dominique Chabot, Louise Champoux, Samantha Brimble, Mehran Alaee, Sarah Marteinson, Da Chen, Vince Palace, David M Bird, Robert J Letcher
Flame retardants (FR) are industrial chemicals and some are proven environmental contaminants that accumulate in predatory birds. Few studies have examined the influence of diet on FR profiles in nestling raptors and the possible physiological implications of such FR exposure. The objectives of this research were (1) to determine spatial patterns of ≤ 48 polybrominated diphenyl ether (PBDE) congeners and ≤ 26 non-PBDE FRs, including organophosphate esters (OPEs), in nestling peregrine falcons (Falco peregrinus) across the Canadian Great Lakes-St...
June 6, 2017: Environmental Research
https://www.readbyqxmd.com/read/28591181/combined-use-of-tri-axial-accelerometers-and-gps-reveals-the-flexible-foraging-strategy-of-a-bird-in-relation-to-weather-conditions
#15
Jesús Hernández-Pliego, Carlos Rodríguez, Giacomo Dell'Omo, Javier Bustamante
Tri-axial accelerometry has proved to be a useful technique to study animal behavior with little direct observation, and also an effective way to measure energy expenditure, allowing a refreshing revisit to optimal foraging theory. This theory predicts that individuals should gain the most energy for the lowest cost in terms of time and energy when foraging, in order to maximize their fitness. However, during a foraging trip, central-place foragers could face different trade-offs during the commuting and searching parts of the trip, influencing behavioral decisions...
2017: PloS One
https://www.readbyqxmd.com/read/28590429/spatial-characterization-of-radio-propagation-channel-in-urban-vehicle-to-infrastructure-environments-to-support-wsns-deployment
#16
Fausto Granda, Leyre Azpilicueta, Cesar Vargas-Rosales, Peio Lopez-Iturri, Erik Aguirre, Jose Javier Astrain, Jesus Villandangos, Francisco Falcone
Vehicular ad hoc Networks (VANETs) enable vehicles to communicate with each other as well as with roadside units (RSUs). Although there is a significant research effort in radio channel modeling focused on vehicle-to-vehicle (V2V), not much work has been done for vehicle-to-infrastructure (V2I) using 3D ray-tracing tools. This work evaluates some important parameters of a V2I wireless channel link such as large-scale path loss and multipath metrics in a typical urban scenario using a deterministic simulation model based on an in-house 3D Ray-Launching (3D-RL) algorithm at 5...
June 7, 2017: Sensors
https://www.readbyqxmd.com/read/28590353/proposed-clinical-pathway-for-non-operative-management-of-high-grade-pediatric-pancreatic-injuries-based-on-a-multicenter-analysis-a-pediatric-trauma-society-collaborative
#17
Bindi J Naik-Mathuria, Eric H Rosenfeld, Adam Vogel, Ankush Gosain, Randall Burd, Richard A Falcone, Rajan Thakkar, Barbara Gaines, David Mooney, Mauricio Escobar, Mubeen Jafri, Anthony Stallion, Denise B Klinkner, Robert Russell, Brendan Campbell, Rita V Burke, Jeffrey Upperman, David Juang, Shawn St Peter, Stephon J Fenton, Marianne Beaudin, Hale Wills, Stephanie Polites, Adam Pattyn, Christine Leeper, Laura V Veras, Ilan Maizlin, Shefali Thaker, Alexis Smith, Megan Waddell, Joseph Drews, James Gilmore, Lindsey Armstrong, Alexis Alex Ler, Suzanne Moody, Brandon Behrens, Laurence Carmant
BACKGROUND: Guidelines for non-operative management (NOM) of high-grade pancreatic injuries in children have not been established, and wide practice variability exists. The purpose of this study was to evaluate common clinical strategies across multiple pediatric trauma centers in order to develop a consensus-based standard clinical pathway. METHODS: A multicenter, retrospective review was conducted of children with high-grade (AAST grade III-V) pancreatic injuries treated with NOM between 2010-15...
June 6, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28590347/focused-assessment-with-sonography-for-trauma-fast-in-children-following-blunt-abdominal-trauma-a-multi-institutional-analysis
#18
Bennett W Calder, Adam M Vogel, Jingwen Zhang, Patrick D Mauldin, Eunice Y Huang, Kate B Savoie, Matthew T Santore, KuoJen Tsao, Tiffany G Ostovar-Kermani, Richard A Falcone, M Sidney Dassinger, John Recicar, Jeffrey H Haynes, Martin L Blakely, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David P Mooney, Chinwendu Onwubiko, Jeffrey S Upperman, Jessica A Zagory, Christian J Streck
INTRODUCTION: The utility of FAST in children is poorly defined with considerable practice variation. Our purpose was to investigate the role of FAST for intraabdominal injury (IAI) and IAI requiring acute intervention (IAI-I) in children following blunt abdominal trauma (BAT). METHODS: We prospectively enrolled children <16 years following BAT at 14 Level-One Pediatric Trauma Centers over a 1-year period. Patients who underwent FAST were compared to those that did not using descriptive statistics and univariate analysis; p<0...
June 6, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28583738/predictors-of-mortality-in-nursing-home-residents-with-pneumonia-a-multicenter-study
#19
Marco Falcone, Alessandro Russo, Flaminia Gentiloni Silverj, Daniela Marzorati, Renzo Bagarolo, Massimo Monti, Rosella Velleca, Roberto D'Angelo, Antonino Frustaglia, Ginetto Carlo Zuccarelli, Roberto Prina, Marco Vignati, Maria Grazia Marnati, Mario Venditti, Marco Tinelli
OBJECTIVES: To evaluate predictors of mortality in patients residing in nursing-homes (NHs) or long-term care facilities (LTCFs) with diagnosis of NH-acquired pneumonia (NHAP). METHODS: We conducted an observational, prospective study (December 2013-December 2015) of patients residing in 9 NHs/LTCFs of Central and Northern Italy with diagnosis of NHAP. Data on demographics, comorbidities, microbiology, and therapies were entered in an electronic database. To identify risk factors associated with 30-day mortality, we performed univariable and multivariable analyses, and predictors were internally validated using a bootstrap resampling procedure...
June 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28578974/aot-reverse-micelles-as-versatile-reaction-media-for-chitosan-nanoparticles-synthesis
#20
M Soledad Orellano, Carina Porporatto, Juana J Silber, R Darío Falcone, N Mariano Correa
It is known that Chitosan (Ch) can be used in several applications, such as antimicrobial agent or as drug delivery agent. However, being its water dispersibility very low at physiological pH it is necessary to find a way to improve it. One attractive strategy is to synthesize Chitosan Nanoparticles (Ch-NPs). In this work, a versatile method to obtain Ch-NPs with different and controlled sizes, that were successfully prepared by cross-linking reaction of glutaraldehyde and native chitosan inside of n-heptane/sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT)/water reverse micelles (RMs) is presented...
September 1, 2017: Carbohydrate Polymers
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