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https://www.readbyqxmd.com/read/29778393/fertility-preservation-in-pediatric-female-cancer-patients
#1
Sara E Arian, Rebecca L Flyckt, Richard Herman, Hadi Erfani, Tommaso Falcone
OBJECTIVE: To describe and demonstrate ovarian tissue cryopreservation (OTC) as an emerging fertility preservation technique DESIGN: Video presentation. SETTING: University hospital. PATIENT(S): A 6 year-old female patient diagnosed with aplastic anemia with plan for bone marrow transplantation underwent laparoscopic unilateral oophorectomy in conjunction with surgical procedure for port placement by the pediatric surgeon, followed by cryopreservation of ovarian tissue...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29777239/inference-about-causation-between-body-mass-index-and-dna-methylation-in-blood-from-a-twin-family-study
#2
Shuai Li, Ee Ming Wong, Minh Bui, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Pierre-Antoine Dugué, Roger L Milne, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper
BACKGROUND: Several studies have reported DNA methylation in blood to be associated with body mass index (BMI), but few have investigated causal aspects of the association. We used a twin family design to assess this association at two life points and applied a novel analytical approach to appraise the evidence for causality. METHODS: The methylation profile of DNA from peripheral blood was measured for 479 Australian women from 130 twin families. Linear regression was used to estimate the associations of DNA methylation at ~410,000 cytosine-guanine dinucleotides (CpGs), and of the average DNA methylation at ~20,000 genes, with current BMI, BMI at age 18-21 years, and the change between the two (BMI change)...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29769348/discovery-and-sequence-analysis-of-four-deltacoronaviruses-from-birds-in-the-middle-east-suggest-interspecies-jumping-and-recombination-as-potential-mechanism-for-avian-to-avian-and-avian-to-mammalian-transmission
#3
Susanna K P Lau, Emily Y M Wong, Chi-Ching Tsang, Syed Shakeel Ahmed, Rex K H Au-Yeung, Kwok-Yung Yuen, Ulrich Wernery, Patrick C Y Woo
The emergence of Middle East respiratory syndrome showed once again that coronaviruses (CoVs) in animals are potential source for epidemics in humans. To explore the diversity of deltacoronaviruses in animals in the Middle East, we tested fecal samples from 1,356 mammals and birds in Dubai. Four novel deltacoronaviruses were detected from eight birds of four species by RT-PCR: FalCoV UAE-HKU27 from a falcon, HouCoV UAE-HKU28 from a houbara bustard, PiCoV UAE-HKU29 from a pigeon and QuaCoV UAE-HKU30 from five quails...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29769167/impact-of-sex-on-comparative-outcomes-of-bivalirudin-versus-unfractionated-heparin-in-patients-with-acute-coronary-syndromes-undergoing-invasive-management-a-pre-specified-analysis-of-the-matrix-trial
#4
Giuseppe Gargiulo, Bruno R da Costa, Enrico Frigoli, Cataldo Palmieri, Marco Stefano Nazzaro, Camillo Falcone, Armando Liso, Carlo Vigna, Fabio Abate, Marco Comeglio, Roberto Diletti, Gabriele Gabrielli, Emilio Di Lorenzo, Pietro Mazzarotto, Marco Zimarino, Claudio Moretti, Antonio Colombo, Carlo Penzo, Giampaolo Pasquetto, Salvatore Brugaletta, Fabio Ferrari, Gavino Casu, Vincenzo Guiducci, Antonio Dellavalle, Francesco Liistro, Ciro Mauro, Arnoud W J Van't Hof, Elmir Omerovic, Salvatore Curello, Jose Maria de la Torre Hernandez, Stefano De Servi, Flavia Belloni, Stephan Windecker, Marco Valgimigli
AIMS: To assess whether bivalirudin compared with unfractionated heparin (UFH) is associated with consistent outcomes in male and female patients with acute coronary syndrome (ACS) undergoing invasive management. METHODS AND RESULTS: In the MATRIX program,7213 patients were randomized to bivalirudin or UFH.Patients in bivalirudin group were subsequently assigned to receive or not to receive a post-PCI infusion.The 30-day coprimary outcomes were major adverse cardiovascular and cerebrovascular events (MACE),defined as death,myocardial infarction,or stroke,and net adverse clinical events (NACE),defined as MACE or major bleeding...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29767349/-primary-ophthalmological-diagnosis-of-treponema-pallidum-infection-a-case-series
#5
D Grassl, V Brandi Falcone, K Gorte, G Sauder
This report is on five patients (four men and one woman) between the age of 24 and 66 years old who presented with unclear visual impairment in our clinic between 2009 and 2016 for co-evaluation. The clinical picture included intermediate uveitis, chorioretinitis, panuveitis and bilateral spontaneous cystoid macular edema. None of the patients reported systemic or dermatological symptoms. In all five patients, serological testing revealed a Treponema pallidum infection as the reason for ocular inflammation...
May 16, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29760869/metabolic-alterations-in-urine-extracellular-vesicles-are-associated-to-prostate-cancer-pathogenesis-and-progression
#6
Marc Clos-Garcia, Ana Loizaga-Iriarte, Patricia Zuñiga-Garcia, Pilar Sánchez-Mosquera, Ana Rosa Cortazar, Esperanza González, Verónica Torrano, Cristina Alonso, Miriam Pérez-Cormenzana, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Azucena Castro, Felix Royo, Miguel Unda, Arkaitz Carracedo, Juan M Falcón-Pérez
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have previously identified proteins and RNAs with differential abundance in urinary EVs from prostate cancer (PCa) patients compared to benign prostate hyperplasia (BPH). Here, we focused on the analysis of the metabolites contained in urinary EVs collected from patients with PCa and BPH. Targeted metabolomics analysis of EVs was performed by ultra-high-performance liquid chromatography-mass spectrometry...
2018: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/29758672/generation-of-intermittent-gravitocapillary-waves-via-parametric-forcing
#7
Gustavo Castillo, Claudio Falcón
We report on the generation of an intermittent wave field driven by a horizontally moving wave maker interacting with Faraday waves. The spectrum of the local gravitocapillary surface wave fluctuations displays a power law in frequency for a wide range of forcing parameters. We compute the probability density function of the local surface height increments, which show that they change strongly across time scales. The structure functions of these increments are shown to display power laws as a function of the time lag, with exponents that are nonlinear functions of the order of the structure function...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29757794/delayed-post-caudal-catheter-placement-pseudomeningocele-a-case-report
#8
Victoria A Bradford, Ricardo J Falcon, Timothy R Petersen, Codruta N Soneru
We present a rare case of a 7-month-old infant who developed a pseudomeningocele 16 days after an uneventful caudal catheter placement. The patient did not exhibit neurological deficits or signs of infection, and the mass increased in size with Valsalva maneuver. Pseudomeningocele, an abnormal collection of cerebrospinal fluid around an opening in the dura mater, can be iatrogenic or traumatic. Regional anesthesia is rarely the cause. Recognizing diagnostic features such as the lack of infectious signs and mass compressibility can prevent misdiagnosis and inappropriate invasive treatment...
May 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29756284/factors-associated-with-atxn2-cag-caa-repeat-intergenerational-instability-in-spinocerebellar-ataxia-type-2
#9
L E Almaguer-Mederos, J M L Mesa, Y González-Zaldívar, D Almaguer-Gotay, D Cuello-Almarales, R Aguilera-Rodríguez, N S Falcón, S Gispert, G Auburger, L Velázquez-Pérez
Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder caused by the unstable expansion of a CAG/CAA repeat in the ATXN2 gene, which normally encodes 22 glutamines (Q22). A large study was conducted to characterize the CAG/CAA repeat intergenerational instability in SCA2 families. Large normal alleles (LNA, Q24-31) were significantly more unstable upon maternal transmissions. In contrast, expanded alleles (EA, Q32-750) were significantly more unstable during paternal transmissions, in correlation with repeat length...
May 14, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29753801/a-comparative-study-between-2-different-grafts-used-as-patches-after-plaque-incision-and-inflatable-penile-prosthesis-implantation-for-end-stage-peyronie-s-disease
#10
Marco Falcone, Mirko Preto, Carlo Ceruti, Massimiliano Timpano, Giulio Garaffa, Omidreza Sedigh, Mattia Sibona, Marco Oderda, Paolo Gontero, Luigi Rolle
BACKGROUND: Although many grafts have been used for plaque incision with grafting (PIG) and penile prosthesis (PP) implantation, there is no evidence that favors 1 specific graft over another. AIM: To compare fibrin-coated collagen fleece (TachoSil; Baxter International, Deerfield, IL, USA) with porcine small intestinal submucosa (SIS; Cook Biotech, West Lafayette, IN, USA) as grafts. METHODS: From January 2007 to January 2015, 60 non-randomized consecutive patients affected by end-stage Peyronie disease underwent PIG and PP implantation (AMS 700CX; Boston Scientific, Marlborough, MA, USA)...
May 9, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29750705/thickened-endometrium-in-postmenopausal-women-with-an-initial-biopsy-of-limited-benign-surface-endometrium-clinical-outcome-and-subsequent-pathologic-diagnosis
#11
Josephine K T Dermawan, Christine Hur, Maria G Uberti, Rebecca Flyckt, Tommaso Falcone, Jennifer Brainard, Fadi W Abdul-Karim
Endometrial biopsy or curetting is indicated for postmenopausal women with abnormal uterine bleeding and/or thickened endometrium. Often, endometrial biopsy or curetting yields limited benign surface endometrium, which may indicate insufficient sampling. This study addresses the clinical outcome and subsequent pathologic diagnoses in postmenopausal women who received this initial diagnosis. Among a total of 370 endometrial biopsy or curetting between 2012 and 2015, 192 (52%) were diagnosed as limited benign surface endometrial epithelium...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29745821/regulation-of-osteogenesis-by-long-noncoding-rnas-an-epigenetic-mechanism-contributing-to-bone-formation
#12
Coralee E Tye, Joseph R Boyd, Natalie A Page, Michelle M Falcone, Janet L Stein, Gary S Stein, Jane B Lian
Long noncoding RNAs (lncRNAs) have recently emerged as novel regulators of lineage commitment, differentiation, development, viability, and disease progression. Few studies have examined their role in osteogenesis; however, given their critical and wide-ranging roles in other tissues, lncRNAs are most likely vital regulators of osteogenesis. In this study, we extensively characterized lncRNA expression in mesenchymal cells during commitment and differentiation to the osteoblast lineage using a whole transcriptome sequencing approach (RNA-Seq)...
December 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29739893/trifluridine-tipiracil-tas-102-in-refractory-metastatic-colorectal-cancer-a-multicenter-register-in-the-frame-of-the-italian-compassionate-use-program
#13
Chiara Cremolini, Daniele Rossini, Erika Martinelli, Filippo Pietrantonio, Sara Lonardi, Silvia Noventa, Emiliano Tamburini, Giovanni Luca Frassineti, Stefania Mosconi, Federico Nichetti, Sabina Murgioni, Teresa Troiani, Beatrice Borelli, Gemma Zucchelli, Alessandro Dal Maso, Vincenzo Sforza, Gianluca Masi, Carlotta Antoniotti, Maria Di Bartolomeo, Rosalba Miceli, Fortunato Ciardiello, Alfredo Falcone
BACKGROUND: TAS-102 is indicated for patients with metastatic colorectal cancer (mCRC) previously treated with, or not considered candidates for, available therapies. Given the complete inefficacy in half of patients, the lack of predictive factors, the palliative setting, and the financial and clinical toxicity, optimizing the cost-benefit ratio is crucial. The "ColonLife" nomogram allows an estimate of the 12-week life expectancy of patients with refractory mCRC. MATERIALS AND METHODS: We collected data from patients treated at eight Italian centers in the compassionate use program...
May 8, 2018: Oncologist
https://www.readbyqxmd.com/read/29736739/inflammatory-and-anti-inflammatory-responses-co-exist-inside-lung-granuloma-of-fatal-cases-of-coccidioidomycosis-a-pilot-report
#14
Heidi G Rodriguez-Ramirez, Adolfo Soto-Dominguez, Gloria M González, Oralia Barboza-Quintana, Mario C Salinas-Carmona, Luis A Ceceñas-Falcon, Roberto Montes-de-Oca-Luna, Alma Y Arce-Mendoza, Adrian G Rosas-Taraco
Coccidioidomycosis is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii. These fungi are endemic in the southern USA and northern Mexico. Immunocompromised patients are susceptible to develop severe forms of this fungal infection. Cytokines play an important role in controlling the fungal infection, but little is known about the predominant immunological environment in human lung tissue from fatal cases. Our aim was to analyze the pro-inflammatory and anti-inflammatory cytokines and monocyte/macrophages markers (CD14 and CD206) in the granulomas of six fatal cases of coccidioidomycosis...
May 7, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29733116/collagenase-clostridium-histolyticum-for-the-treatment-of-peyronie-s-disease-a-prospective-italian-multicentric-study
#15
M Capece, A Cocci, G Russo, G Cito, G Giubilei, G Cacciamani, G Garaffa, M Falcone, M Timpano, G Tasso, F Sessa, R Campi, F Di Maida, T Cai, G Morelli, B Giammusso, P Verze, A Palmieri, D Ralph, V Mirone, N Mondaini
Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. However, only few monocentric studies are available in the current literature and this is the first national multicentric study focusing on this new treatment. In five Italian centres, 135 patients have completed the treatment with three injections of CCH using Ralph's shortened modified protocol...
May 7, 2018: Andrology
https://www.readbyqxmd.com/read/29724430/acr-appropriateness-criteria-%C3%A2-hematuria-child
#16
Jonathan R Dillman, Cynthia K Rigsby, Ramesh S Iyer, Adina L Alazraki, Sudha A Anupindi, Brandon P Brown, Sherwin S Chan, Scott R Dorfman, Richard A Falcone, Matthew D Garber, Jie C Nguyen, Craig A Peters, Nabile M Safdar, Andrew T Trout, Boaz K Karmazyn
Hematuria is the presence of red blood cells in the urine, either visible to the eye (macroscopic hematuria) or as viewed under the microscope (microscopic hematuria). The clinical evaluation of children and adolescents with any form of hematuria begins with a meticulous history and thorough evaluation of the urine. The need for imaging evaluation depends on the clinical scenario in which hematuria presents, including the suspected etiology. Ultrasound and CT are the most common imaging methods used to assess hematuria in children, although other imaging modalities may be appropriate in certain instances...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29720885/successful-second-line-metronomic-temozolomide-in-metastatic-paraganglioma-case-reports-and-review-of-the-literature
#17
Isabel Tena, Garima Gupta, Marcos Tajahuerce, Marta Benavent, Manuel Cifrián, Alejandro Falcon, María Fonfria, Maribel Del Olmo, Rosa Reboll, Antonio Conde, Francisca Moreno, Julia Balaguer, Adela Cañete, Rosana Palasí, Pilar Bello, Alfredo Marco, José Luis Ponce, Juan Francisco Merino, Antonio Llombart, Alfredo Sanchez, Karel Pacak
Metastatic pheochromocytoma and paraganglioma (mPHEO/PGL) are frequently associated with succinate dehydrogenase B ( SDHB ) mutations. Cyclophosphamide-dacarbazine-vincristine (CVD) regimen is recommended as standard chemotherapy for advanced mPHEO/PGL. There is limited evidence to support the role of metronomic schemes (MS) of chemotherapy in mPHEO/PGL treatment. We report 2 patients with SDHB -related mPGL who received a regimen consisting of MS temozolomide (TMZ) and high-dose lanreotide after progression on both CVD chemotherapy and high-dose lanreotide...
2018: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/29720308/four-electron-reduction-and-functionalization-of-n%C3%A2-by-a-uranium-iii-bridging-nitride
#18
Marta Falcone, Marinella Mazzanti
N2 is a cheap and widely available but very unreactive molecule. Notably, the only industrial process for the conversion of dinitrogen is the Haber-Bosch process to form ammonia, but under very harsh conditions (high temperature and pressure). Here, we review our recent research leading to the reduction of dinitrogen by four electrons, under ambient conditions by a uranium(III) bridging nitride, K3 U-N-U, where two uranium(III) cations are linked by a nitride group and a flexible metal-ligand scaffold. We also show that the bound dinitrogen can be further functionalized under mild conditions: the addition of acid, hydrogen and protons or carbon monoxide to the uranium hydrazido complex yields to the cleavage of the N-N single bond and to the formation of new N-H and N-C bonds...
April 25, 2018: Chimia
https://www.readbyqxmd.com/read/29714787/observation-of-an-optical-spring-with-a-beam-splitter
#19
Jonathan Cripe, Baylee Danz, Benjamin Lane, Mary Catherine Lorio, Julia Falcone, Garrett D Cole, Thomas Corbitt
We present the experimental observation of an optical spring without the use of an optical cavity. The optical spring is produced by interference at a beam splitter and, in principle, does not have the damping force associated with optical springs created in detuned cavities. The experiment consists of a Michelson-Sagnac interferometer (with no recycling cavities) with a partially reflective GaAs microresonator as the beam splitter that produces the optical spring. Our experimental measurements at input powers of up to 360 mW show the shift of the optical spring frequency as a function of power and are in excellent agreement with theoretical predictions...
May 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29705332/transcriptional-profiling-of-the-cam-plant-agave-salmiana-reveals-conservation-of-a-genetic-program-for-regeneration
#20
Sergio Alan Cervantes-Pérez, Annie Espinal-Centeno, Araceli Oropeza-Aburto, Juan Caballero-Pérez, Francisco Falcon, Alejandro Aragón-Raygoza, Lino Sánchez-Segura, Luis Herrera-Estrella, Andrés Cruz-Hernández, Alfredo Cruz-Ramírez
In plants, the best characterized plant regeneration process is de novo organogenesis. This type of regeneration is characterized by the formation of a multicellular structure called callus. Calli are induced via phytohormone treatment of plant sections. The callus formation in plants like Agave species with Crassulacean Acid Metabolism (CAM) is poorly studied. In this study, we induced callus formation from Agave salmiana leaves and describe cell arrangement in this tissue. Moreover, we determined and analyzed the transcriptional program of calli, as well as those of differentiated root and leaf tissues, by using RNA-seq...
April 26, 2018: Developmental Biology
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