Nadezhda B Rudometova, Anastasia A Fando, Lyubov A Kisakova, Denis N Kisakov, Mariya B Borgoyakova, Victoria R Litvinova, Vladimir A Yakovlev, Elena V Tigeeva, Danil I Vahitov, Sergey V Sharabrin, Dmitriy N Shcherbakov, Veronika I Evseenko, Ksenia I Ivanova, Andrei S Gudymo, Tatiana N Ilyicheva, Vasiliy Yu Marchenko, Alexander A Ilyichev, Andrey P Rudometov, Larisa I Karpenko
In this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical analysis showed that the recombinant hemagglutinin was recognized by the serum of ferrets infected with influenza A (H5N8) virus, indicating that its antigenic properties were retained. Two groups of Balb/c mice were immunized with intramuscular injection of recombinant hemagglutinin or propiolactone inactivated A/Astrakhan/3212/2020 (H5N8) influenza virus...
January 29, 2024: Vaccines