Madison Parrot, Bhuvanesh Yathavan, Olga Averin, Logan Hoggard, Joseph E Rower, Michael Voight, Danielle Greene, Ariel Tarrell, Aviva Whelan, Hamidreza Ghandehari, Nancy Murphy, Venkata Yellepeddi
Sialorrhea or drooling is a common problem in children and adults with neurodevelopmental disorders. It can negatively impact the quality of life due to its physical and psychological manifestations. Providers commonly prescribe atropine eye drops for topical administration to the oral mucosa, as an off-label treatment to manage sialorrhea. However, the off-label use of atropine eye drops can be associated with medication and dosing errors and systemic side effects. To address these limitations of treatment, we developed a mucoadhesive topical oral gel formulation of atropine as an alternative route to off-label administration of atropine eye drops...
March 2024: Clinical and Translational Science