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JOURNAL ARTICLE
Dimitrios C Ladakis, Edoardo Pedrini, Maria I Reyes-Mantilla, Muraleetharan Sanjayan, Matthew D Smith, Kathryn C Fitzgerald, Carlos A Pardo, Daniel S Reich, Martina Absinta, Pavan Bhargava
BACKGROUND AND OBJECTIVES: People with multiple sclerosis (MS) have a dysregulated circulating metabolome, but the metabolome of MS brain lesions has not been studied. The aims of this study were to identify differences in the brain tissue metabolome in MS compared with controls and to assess its association with the cellular profile of corresponding tissue. METHODS: MS tissues included samples from the edge and core of chronic active or inactive lesions and periplaque white matter (WM)...
May 2024: Neurology® Neuroimmunology & Neuroinflammation
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JOURNAL ARTICLE
Yan Xie, Yihao Yao, Nanxi Shen, Yuanhao Li, Hongquan Zhu, Jun Lu, Dong Liu, Yujie Ding, Yan Zhang, Wenzhen Zhu
BACKGROUND: Paramagnetic rim lesions (PRLs) on susceptibility magnetic resonance sequences have been suggested as an imaging marker of disease progression in multiple sclerosis. This retrospective cross-sectional study aimed to investigate the impact of PRLs on cortical thickness and gray matter (GM) to white matter (WM) contrast in relapsing-remitting multiple sclerosis (RRMS). METHODS: A total of 82 RRMS patients (40 patients with at least 1 PRL and 42 patients without PRL) and 43 healthy controls (HC) were included in this study...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
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JOURNAL ARTICLE
Hongyin Tang, Xianglian Liao, Jian Yao, Yilan Xing, Xin Zhao, Weibin Cheng, Tianxiang Gu, Yan Huang, Guang Xu, Ping Luan, Junzhang Tian, Guihua Li
BACKGROUND: Postural instability and gait disorder dominant (PIGD) is one of the most common disabling symptoms of Parkinson's disease (PD), which seriously affects patients' quality of life. Therefore, it is essential to identify PIGD and develop targeted interventions to reduce the risk of PIGD in PD patients. AIM: This study aimed to investigate the gait characteristics of PD patients based on wearable devices and to establish a predictive model for their related influencing factors...
April 2024: Brain and Behavior
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JOURNAL ARTICLE
Lan-Wan Wang, Kuan-Hung Cho, Pi-Yu Chao, Li-Wei Kuo, Chia-Wen Chiang, Chien-Ming Chao, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Lin, Chung-Ching Chio
We aimed to evaluate whether white and gray matter microstructure changes observed with magnetic resonance imaging (MRI)-based diffusion tensor imaging (DTI) can be used to reflect the progression of chronic brain trauma. The MRI-DTI parameters, neuropathologic changes, and behavioral performance of adult male Wistar rats that underwent moderate (2.1 atm on day "0") or repeated mild (1.5 atm on days "0" and "2") traumatic brain injury (TBI or rmTBI) or sham operation were evaluated at 7 days, 14 days, and 1-9 months after surgery...
March 27, 2024: Scientific Reports
#25
Ju Hye Kim, Ji Yeon Chung, Jeong Bin Bong
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare systemic inflammatory disease commonly characterized by histiocyte infiltration in multiple organs, such as the liver, spleen, lymph nodes, bone marrow, and central nervous system. The clinical features of HLH include fever, splenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and elevated blood ferritin levels. HLH is categorized as either primary or secondary. Coronavirus disease 2019 (COVID-19) vaccines may occasionally trigger secondary HLH, which is related to hyperinflammatory syndrome...
2024: Frontiers in Neurology
#26
JOURNAL ARTICLE
Sonia L E Brownsett, Leeanne M Carey, David Copland, Alistair Walsh, Aleksi J Sihvonen
Cognitive deficits are a common and debilitating consequence of stroke, yet our understanding of the structural neurobiological biomarkers predicting recovery of cognition after stroke remains limited. In this longitudinal observational study, we set out to investigate the effect of both focal lesions and structural connectivity on poststroke cognition. Sixty-two patients with stroke underwent advanced brain imaging and cognitive assessment, utilizing the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE), at 3-month and 12-month poststroke...
April 2024: Human Brain Mapping
#27
JOURNAL ARTICLE
Masazumi Fujii
What is the most important factor to achieve successful surgery for deep-seated brain tumors with preservation of brain functions? Definitely, it is to identify the tumor origin site at which a tumor arose and select appropriate surgical approaches that immediately lead directly to the site in the early stage of surgery, minimizing damages of cortices and important white matter bundles, and controlling main arterial supply to the tumor. For this, neurosurgeons must have thorough knowledge of brain anatomy and function, and tailor the best surgical approach for each patient, based on three-dimensional anatomical simulation...
March 2024: No Shinkei Geka. Neurological Surgery
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JOURNAL ARTICLE
Stefano Moriconi, Omar Rodríguez-Núñez, Romain Gros, Leonard A Felger, Theoni Maragkou, Ekkehard Hewer, Angelo Pierangelo, Tatiana Novikova, Philippe Schucht, Richard McKinley
PURPOSE: Wide-field imaging Mueller polarimetry is a revolutionary, label-free, and non-invasive modality for computer-aided intervention; in neurosurgery, it aims to provide visual feedback of white matter fibre bundle orientation from derived parameters. Conventionally, robust polarimetric parameters are estimated after averaging multiple measurements of intensity for each pair of probing and detected polarised light. Long multi-shot averaging, however, is not compatible with real-time in vivo imaging, and the current performance of polarimetric data processing hinders the translation to clinical practice...
March 19, 2024: International Journal of Computer Assisted Radiology and Surgery
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JOURNAL ARTICLE
Jasper Holleman, Makrina Daniilidou, Ingemar Kåreholt, Malin Aspö, Göran Hagman, Chinedu T Udeh-Momoh, Gabriela Spulber, Miia Kivipelto, Alina Solomon, Anna Matton, Shireen Sindi
BACKGROUND: Neuroinflammation is a hallmark of the Alzheimer's disease (AD) pathogenic process. Cortisol dysregulation may increase AD risk and is related to brain atrophy. This cross-sectional study aims to examine interactions of cortisol patterns and neuroinflammation markers in their association with neuroimaging correlates. METHOD: 134 participants were recruited from the Karolinska University Hospital memory clinic (Stockholm, Sweden). Four visual rating scales were applied to magnetic resonance imaging or computed tomography scans: medial temporal lobe atrophy (MTA), global cortical atrophy (GCA), white matter lesions (WML), and posterior atrophy...
March 17, 2024: Brain, Behavior, and Immunity
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JOURNAL ARTICLE
Han Lv, Na Zeng, Mengyi Li, Jing Sun, Ning Wu, Mingze Xu, Qian Chen, Xinyu Zhao, Shuohua Chen, Wenjuan Liu, Xiaoshuai Li, Pengfei Zhao, Max Wintermark, Ying Hui, Jing Li, Shouling Wu, Zhenchang Wang
Background: The cumulative effect of body mass index (BMI) on brain health remains ill-defined. The effects of overweight on brain health across different age groups need clarification. We analyzed the effect of cumulative BMI on neuroimaging features of brain health in adults of different ages. Methods: This study was based on a multicenter, community-based cohort study. We modeled the trajectories of BMI over 16 years to evaluate cumulative exposure. Multimodality neuroimaging data were collected once for volumetric measurements of the brain macrostructure, white matter hyperintensity (WMH), and brain microstructure...
2024: Health Data Sci
#31
JOURNAL ARTICLE
Jing Tian, Kun Zhang, Junzhao Cui, Jin Qin, Binbin Wang, Lixia Zhou, Tong Li, Kailin Bu, Zhongzhong Li, Lin Liu, Qisong Wang, Si Yuan, Lina Ma, Ye Wang, Rui Wang, Chaoyue Meng, Biyi Zhou, Li Guo, Xiaoyun Liu
OBJECTIVE: To investigate the factors associated with brain frailty and the effect of brain frailty in patients with anterior circulation large artery occlusion (AC-LAO). METHODS: 1100 patients with AC-LVO consecutively admitted to the Second Hospital of Hebei Medical University, North China between June 2016 and April 2018 were retrospectively analyzed. The variables associated with brain frailty and stroke outcome were analyzed by ANOVA analysis, the Mann-Whitney U test and multiple linear regression...
March 18, 2024: BMC Neurology
#32
JOURNAL ARTICLE
Philippe Quétin, Nicolas Leboucq, Charlotte Boyer, Françoise Crozier, Philippe Delachartre, Marilyne Grinand, Philippe Masson, Olivier Claris
OBJECTIVES: To observe hyperechoic nodular or punctate white matter lesions (HNPL) in a population of preterm infants using routine cranial ultrasound (cUS), to describe the characteristics of HNPL, and to compare them with punctate white matter lesions (PWML) detected in magnetic resonance imaging (MRI). DESIGN: Retrospective observational single-center cohort study. SETTING: Level 2B neonatal unit in France. PATIENTS: 307 infants born <33 weeks gestation undergoing routine cUS with a total of 961 cUS performed...
March 1, 2024: European Journal of Paediatric Neurology: EJPN
#33
REVIEW
Gabriela Cabett Cipolli, Isadora Cristina Ribeiro, Clarissa Lin Yasuda, Márcio Luiz Figueredo Balthazar, André Fattori, Mônica Sanches Yassuda
Little is known about changes in the brain associated with frailty, in particular, which brain areas could be related to frailty in older people without cognitive impairment. This scoping review mapped evidence on functional and/or structural brain changes in frail older adults without cognitive impairment. The methodology proposed by the JBI® was used in this study. The search in PubMed, PubMed PMC, BVS/BIREME, EBSCOHOST, Scopus, Web of Science, Embase, and PROQUEST was conducted up to January 2023. Studies included following the population, concepts, context and the screening and data extraction were performed by two independent reviewers...
March 4, 2024: Archives of Gerontology and Geriatrics
#34
JOURNAL ARTICLE
Josef Vymazal, Zuzana Ryznarova, Aaron M Rulseh
OBJECTIVES: Accurate detection of metastatic brain lesions (MBL) is critical due to advances in radiosurgery. We compared the results of three readers in detecting MBL using T1-weighted 2D spin echo (SE) and sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) sequences with whole-brain coverage at both 1.5 T and 3 T. METHODS: Fifty-six patients evaluated for MBL were included and underwent a standard protocol (1...
March 14, 2024: Insights Into Imaging
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JOURNAL ARTICLE
J Matthijs Biesbroek, Mirthe Coenen, Charles DeCarli, Evan M Fletcher, Pauline M Maillard, Frederik Barkhof, Josephine Barnes, Thomas Benke, Christopher P L H Chen, Peter Dal-Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G Exalto, Nicolai Franzmeier, Saima Hilal, Edith Hofer, Huiberdina L Koek, Andrea B Maier, Cheryl R McCreary, Janne M Papma, Ross W Paterson, Yolande A L Pijnenburg, Anna Rubinski, Reinhold Schmidt, Jonathan M Schott, Catherine F Slattery, Eric E Smith, Carole H Sudre, Rebecca M E Steketee, Charlotte E Teunissen, Esther van den Berg, Wiesje M van der Flier, Narayanaswamy Venketasubramanian, Vikram Venkatraghavan, Meike W Vernooij, Frank J Wolters, Xu Xin, Hugo J Kuijf, Geert Jan Biessels
INTRODUCTION: White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid-β1-42 (Aβ42)-positive status. METHODS: Individual patient data (n = 3,132; mean age 71.5 ± 9 years; 49.3% female) from 11 memory clinic cohorts were harmonized. WMH volumes in 28 regions were related to a vascular risk compound score (VRCS) and Aß42 status (based on cerebrospinal fluid or amyloid positron emission tomography), correcting for age, sex, study site, and total WMH volume...
March 13, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#36
JOURNAL ARTICLE
Kanchi Shah, Vinayak Bhartia, Chandrima Biswas, Arpita Sahu, Prakash M Shetty, Vikas Singh, Parthiban Velayutham, Suyash P Awate, Aliasgar V Moiyadi
BACKGROUND: Neurocognitive function is a key outcome indicator of therapy in brain tumors. Understanding the underlying anatomical substrates involved in domain function and the pathophysiological basis of dysfunction can help ameliorate the effects of therapy and tailor directed rehabilitative strategies. METHODS: Hundred adult diffuse gliomas were co-registered onto a common demographic-specific brain template to create tumor localization maps. Voxel-based lesion symptom (VLSM) technique was used to assign an association between individual voxels and neuropsychological dysfunction in various domains (attention and executive function (A & EF), language, memory, visuospatial/constructive abilities, and visuomotor speed)...
2024: Neuro-oncology advances
#37
JOURNAL ARTICLE
Xiangyue Xiao, Zhicai Dong, Mingyan Yu, Junhua Ding, Maolin Zhang, Sara Cruz, Zaizhu Han, Yan Chen
The hub-and-spoke theory of semantic representation fractionates the neural underpinning of semantic knowledge into two essential components: the sensorimotor modality-specific regions and a crucially important semantic hub region. Our previous study in patients with semantic dementia has found that the hub region is located in the left fusiform gyrus. However, because this region is located within the brain damage in patients with semantic dementia, it is not clear whether the semantic deficit is caused by structural damage to the hub region itself or by its disconnection from other brain regions...
2024: Brain communications
#38
JOURNAL ARTICLE
Raluca Ștefania Badea, Sorina Mihăilă-Bâldea, Athena Ribigan, Anca Negrilă, Nicolae Grecu, Andreea Nicoleta Marinescu, Florina Antochi, Cristina Tiu, Dragos Vinereanu, Bogdan Ovidiu Popescu
BACKGROUND: Patent foramen ovale (PFO) is a prevalent cardiac remnant of fetal anatomy that may pose a risk factor for stroke in some patients, while others can present with asymptomatic white matter (WM) lesions. The current study aimed to test the hypothesis that patients with a PFO who have a history of stroke or transient ischemic attack, compared to those without such a history, have a different burden and distribution of cerebral WM hyperintensities. Additionally, we tested the association between PFO morphological characteristics and severity of shunt, and their impact on the occurrence of ischemic cerebral vascular events and on the burden of cerebral WM lesions...
2024: Frontiers in Neurology
#39
JOURNAL ARTICLE
Aimpavee Keeratiratwattana, Abhinbhen W Saraya, Supada Prakkamakul
PURPOSE: To describe the imaging findings and determine the incidence of a characteristic worm-like pattern along the white matter tracts in neurolisteriosis on CT/MRI. METHODS: An IRB-approved retrospective study in 21 consecutive neurolisteriosis cases during January 2002-July 2020. At least one of the following is required: (1) Positive Listeria monocytogenes (LM) in blood with clinical signs of meningeal irritation and/or abnormal CSF profile, (2) positive LM in blood with signs of encephalitis, (3) positive LM in CSF, (4) positive LM from brain biopsy/aspiration...
March 4, 2024: Neuroradiology
#40
Hamid Ziani, Siham Nasri, Imane Kamaoui, Imane Skiker
Cocaine use is responsible for multiorgan damage, including the brain and lungs. Bilateral and symmetrical involvement of the basal ganglia may be due to toxic, metabolic, vascular, inflammatory, infectious, or tumoral causes. Cocaine-related encephalopathy mainly affects the white matter, while basal ganglia involvement is an uncommon finding. Cocaine-induced lung damage varies clinically and even radiologically, with signs that lack specificity. The diagnosis of cocaine-induced lung or brain injury is based on suggestive radiological signs in the context of cocaine consumption and after the elimination of other etiologies likely to present the same patterns...
January 2024: Curēus
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