keyword
MENU ▼
Read by QxMD icon Read
search

White matter lesions on brain

keyword
https://www.readbyqxmd.com/read/28718218/impact-of-prenatal-immune-challenge-on-the-demyelination-injury-during-adulthood
#1
Abdeslam Mouihate, Hessah Al-Hashash, Sarah Rakhshani-Moghadam, Samah Kalakh
AIM: Brain inflammation is associated with several brain diseases such as multiple sclerosis (MS), a disease characterized by demyelination. Whether prenatal immune challenge affects demyelination-induced inflammation in the white matter during adulthood is unclear. In the present study, we used a well-established experimental model of focal demyelination to assess whether prenatal immune challenge affects demyelination-induced inflammation. METHODS: Pregnant rats were injected with either lipopolysaccharide (100 μg/kg, ip) or pyrogen-free saline...
July 17, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28717668/different-renal-phenotypes-in-related-adult-males-with-fabry-disease-with-the-same-classic-genotype
#2
Renzo Mignani, Mariarita Moschella, Giovanna Cenacchi, Ilaria Donati, Marta Flachi, Daniela Grimaldi, Davide Cerretani, Paola De Giovanni, Marcello Montevecchi, Angelo Rigotti, Alessandro Ravasio
BACKGROUND: Fabry disease related patients with classical mutation usually exhibit similar severe phenotype especially concerning renal manifestation. METHODS: A dry blood spot screening (DBS) and the DNA analysis has been performed in a 48-year-old man (Patient 1) because of paresthesia. RESULTS: The DBS revealed absent leukocyte α-Gal A enzyme activity while DNA analysis identified the I354K mutation. Serum creatinine and e-GFR were in normal range and also albuminuria and proteinuria were absent...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28711407/severe-neuroimaging-anomalies-are-usually-associated-with-random-x-inactivation-in-leucocytes-circulating-dna-in-x-linked-dominant-incontinentia-pigmenti
#3
Volodia Dangouloff-Ros, Smail Hadj-Rabia, Judite Oliveira Santos, Elodie Bal, Isabelle Desguerre, Manoelle Kossorotoff, Isabelle An, Asma Smahi, Christine Bodemer, Arnold Munnich, Julie Steffann, Nathalie Boddaert
Incontinentia Pigmenti (IP) is a skin disorder with neurological impairment in 30% of cases. The most common disease causing mutation is a deletion of exons 4-10 of the IKBKG gene, located on chromosome Xq28, with skewed X-chromosome inactivation in females, but few cases of random X-inactivation have been reported. We have correlated brain anomalies with X-chromosome inactivation status determined on leucocytes circulating DNA. We reviewed MRI of 18 girls with genetically proven IP. We found three patterns of MRI, normal MRI (n=5), mild white matter abnormalities with cortical and corpus callosum atrophy (n=6), and severe cortical abnormalities suggesting a vascular disease (n=7)...
July 10, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28705824/carotid-plaque-morphology-and-ischemic-vascular-brain-disease-on-mri
#4
Q J A van den Bouwhuijsen, M W Vernooij, B F J Verhaaren, H A Vrooman, W J Niessen, G P Krestin, M A Ikram, O H Franco, A van der Lugt
BACKGROUND AND PURPOSE: Vulnerable carotid plaque components are reported to increase the risk of cerebrovascular events. Yet, the relation between plaque composition and subclinical ischemic brain disease is not known. We studied, in the general population, the association between carotid atherosclerotic plaque characteristics and ischemic brain disease on MR imaging. MATERIALS AND METHODS: From the population-based Rotterdam Study, 951 participants underwent both carotid MR imaging and brain MR imaging...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28705817/multinodular-and-vacuolating-neuronal-tumor-of-the-cerebrum-a-new-leave-me-alone-lesion-with-a-characteristic-imaging-pattern
#5
R H Nunes, C C Hsu, A J da Rocha, L L F do Amaral, L F S Godoy, T W Watkins, V H Marussi, M Warmuth-Metz, H C Alves, F G Goncalves, B K Kleinschmidt-DeMasters, A G Osborn
Multinodular and vacuolating neuronal tumor of the cerebrum is a recently reported benign, mixed glial neuronal lesion that is included in the 2016 updated World Health Organization classification of brain neoplasms as a unique cytoarchitectural pattern of gangliocytoma. We report 33 cases of presumed multinodular and vacuolating neuronal tumor of the cerebrum that exhibit a remarkably similar pattern of imaging findings consisting of a subcortical cluster of nodular lesions located on the inner surface of an otherwise normal-appearing cortex, principally within the deep cortical ribbon and superficial subcortical white matter, which is hyperintense on FLAIR...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28692678/bilateral-effects-of-unilateral-cerebellar-lesions-as-detected-by-voxel-based-morphometry-and-diffusion-imaging
#6
Giusy Olivito, Michael Dayan, Valentina Battistoni, Silvia Clausi, Mara Cercignani, Marco Molinari, Maria Leggio, Marco Bozzali
Over the last decades, the importance of cerebellar processing for cortical functions has been acknowledged and consensus was reached on the strict functional and structural cortico-cerebellar interrelations. From an anatomical point of view strictly contralateral interconnections link the cerebellum to the cerebral cortex mainly through the middle and superior cerebellar peduncle. Diffusion MRI (dMRI) based tractography has already been applied to address cortico-cerebellar-cortical loops in healthy subjects and to detect diffusivity alteration patterns in patients with neurodegenerative pathologies of the cerebellum...
2017: PloS One
https://www.readbyqxmd.com/read/28692549/a-case-of-familial-hemophagocytic-lymphohistiocytosis-type-4-with-involvement-of-the-central-nervous-system-complicated-with-infarct
#7
Saliha Ciraci, Alper Ozcan, Mustafa M Ozdemir, Samuel C C Chiang, Bianca Tesi, Akif M Ozdemir, Musa Karakukcu, Turkan Patiroglu, Can Acipayam, Selim Doganay, Hakan Gumus, Ekrem Unal
BACKGROUND: Familial hemophagocytic lymphohistiocytosis (HLH) is a fatal disease affecting infants and very young children. Central nervous system involvement of HLH can cause catastrophic results. METHOD: We present a case with cranial involvement of familial HLH type 4 who showed diffuse infiltration of white matter complicated with intracranial thrombosis. A 5-year-old girl from a consanguineous couple presented with fever and pancytopenia, and was referred to our hematology unit...
July 7, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28685649/misdiagnosis-cns-erdheim-chester-disease-mimicking-clippers
#8
Jillian Berkman, Caleb Ford, Emily Johnson, Beth A Malow, Joseph M Aulino
Introduction Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory central nervous system (CNS) disorder with particular involvement of the pons. Diagnostic criteria include a range of clinical symptoms related to the underlying brainstem pathology, visible with magnetic resonance imaging (MRI). MRI findings include the appearance of punctuate and curvilinear gadolinium enhancement 'peppering' the pons. We discuss a patient presenting with clinical and radiographic characteristics of CLIPPERS who was diagnosed with Erdheim-Chester disease (ECD)...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28676986/incidental-findings-on-cerebral-mri-in-twins-the-older-australian-twins-study
#9
Rebecca Koncz, Adith Mohan, Laughlin Dawes, Anbupalam Thalamuthu, Margaret Wright, David Ames, Teresa Lee, Julian Trollor, Wei Wen, Perminder Sachdev
Incidental findings on structural cerebral magnetic resonance imaging (MRI) are common in healthy subjects, and the prevalence increases with age. There is a paucity of data regarding incidental cerebral findings in twins. We examined brain MRI data acquired from community-dwelling older twins to determine the prevalence and concordance of incidental cerebral findings, as well as the associated clinical implications. Participants (n = 400) were drawn from the Older Australian Twins Study. T1-weighted and T2-weighted fluid-attenuated inversion recovery (FLAIR) cerebral MRI scans were systematically reviewed by a trained, blinded clinician...
July 4, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28671114/associations-of-caide-dementia-risk-score-with-mri-pib-pet-measures-and%C3%A2-cognition
#10
Ruth Stephen, Yawu Liu, Tiia Ngandu, Juha O Rinne, Nina Kemppainen, Riitta Parkkola, Tiina Laatikainen, Teemu Paajanen, Tuomo Hänninen, Timo Strandberg, Riitta Antikainen, Jaakko Tuomilehto, Sirkka Keinänen Kiukaanniemi, Ritva Vanninen, Seppo Helisalmi, Esko Levälahti, Miia Kivipelto, Hilkka Soininen, Alina Solomon
BACKGROUND: CAIDE Dementia Risk Score is the first validated tool for estimating dementia risk based on a midlife risk profile. OBJECTIVES: This observational study investigated longitudinal associations of CAIDE Dementia Risk Score with brain MRI, amyloid burden evaluated with PIB-PET, and detailed cognition measures. METHODS: FINGER participants were at-risk elderly without dementia. CAIDE Risk Score was calculated using data from previous national surveys (mean age 52...
June 27, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28670166/splenial-lesions-of-the-corpus-callosum-disease-spectrum-and-mri-findings
#11
Sung Eun Park, Dae Seob Choi, Hwa Seon Shin, Hye Jin Baek, Ho Cheol Choi, Ji Eun Kim, Hye Young Choi, Mi Jung Park
The corpus callosum (CC) is the largest white matter structure in the brain, consisting of more than 200-250 million axons that provide a large connection mainly between homologous cerebral cortical areas in mirror image sites. The posterior end of the CC is the thickest part, which is called the splenium. Various diseases including congenital to acquired lesions including congenital anomalies, traumatic lesions, ischemic diseases, tumors, metabolic, toxic, degenerative, and demyelinating diseases, can involve the splenium of the CC and their clinical symptoms and signs are also variable...
July 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28669119/mri-volumetric-morphometry-in-vascular-parkinsonism
#12
Vincent Dunet, Jeremy Deverdun, Celine Charroud, Emmanuelle Le Bars, Francois Molino, Sophie Menjot de Champfleur, Florence Maury, Mahmoud Charif, Xavier Ayrignac, Pierre Labauge, Giovanni Castelnovo, Frederic Pinna, Alain Bonafe, Christian Geny, Nicolas Menjot de Champfleur
Vascular parkinsonism is a difficult clinical differential diagnosis in elderly subjects. We aimed at identifying morphometric markers in the brain of elderly patients with vascular parkinsonism (VP) compared with age-matched patients with Parkinson's disease (PD) and healthy controls. In this multicenter prospective study, 46 patients (80 ± 5 years old; male 32) with parkinsonism (32 PD and 14 VP) and 29 controls (mean age 78 ± 3 years; male 21) underwent brain MRI on a 3-T scanner including T1 MPRAGE and FLAIR sequences...
July 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28667060/small-vessel-disease-neurovascular-regulation-and-cognitive-impairment-post-mortem-studies-reveal-a-complex-relationship-still-poorly-understood
#13
REVIEW
Seth Love, J Scott Miners
The contribution of vascular disease to cognitive impairment is under-recognized and the pathogenesis is poorly understood. This information gap has multiple causes, including a lack of post-mortem validation of clinical diagnoses of vascular cognitive impairment (VCI) or vascular dementia (VaD), the exclusion of cases with concomitant neurodegenerative disease when diagnosing VCI/VaD, and a lack of standardization of neuropathological assessment protocols for vascular disease. Other contributors include a focus on end-stage destructive lesions to the exclusion of more subtle types of diffuse brain injury, on structural abnormalities of arteries and arterioles to the exclusion of non-structural abnormalities and capillary damage, and the use of post-mortem sampling strategies that are biased towards the identification of neurodegenerative pathologies...
July 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28658309/microstructural-integrity-of-white-matter-tracts-amongst-older-fallers-a-dti-study
#14
Yoke Queen Wong, Li Kuo Tan, Pohchoo Seow, Maw Pin Tan, Khairul Azmi Abd Kadir, Anushya Vijayananthan, Norlisah Ramli
OBJECTIVES: This study assesses the whole brain microstructural integrity of white matter tracts (WMT) among older individuals with a history of falls compared to non-fallers. METHODS: 85 participants (43 fallers, 42 non-fallers) were evaluated with conventional MRI and diffusion tensor imaging (DTI) sequences of the brain. DTI metrics were obtained from selected WMT using tract-based spatial statistics (TBSS) method. This was followed by binary logistic regression to investigate the clinical variables that could act as confounding elements on the outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28658158/neonatal-onset-carbamoyl-phosphate-synthetase-i-deficiency-a-case-report
#15
Xiaoyan Yang, Jing Shi, Haihong Lei, Bin Xia, Dezhi Mu
RATIONALE: The carbamoyl phosphate synthetase I deficiency (CPS1D) was rare and hard to diagnose due to its atypical symptoms. Brain magnetic resonance imaging (MRI) was typically unavailable in other reports because most patients died before diagnosis was confirmed. Furthermore, it was found a new mutation that had not been described previously. PATIENT CONCERNS: This is a case of neonatal-onset CPS1D with nonspecific clinical manifestations and deteriorating rapidly...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28649664/quantitative-analysis-of-the-spatial-distribution-of-metastatic-brain-lesions
#16
Ted K Yanagihara, Albert Lee, Tony J C Wang
Brain metastases (BMs) are the most common intracranial malignancy and afflict ~10%-20% of patients with cancer. BMs tend to present at the boundaries of gray and white matter because of the distribution of small vessels. In addition, metastases may not be randomly distributed across gross anatomical regions of the brain, but this has not previously been quantified. We retrospectively analyzed a series of 28 patients with recurrent BMs with a total of 150 lesions. Each lesion was manually defined based on T1 gadolinium-enhanced imaging...
March 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28645128/-headache-news
#17
Hans-Christoph Diener, Charly Gaul, Dagny Holle-Lee, Lazaros Lazaridis, Steffen Nägel, Mark Obermann
A review of the latest and most relevant information on different disorders of head and facial pain is presented. News from epidemiologic studies regarding the relationship between migraine and patent foramen ovale, the cardiovascular risk in migraine, and migraine behavior during menopause, and the development of white matter lesions or migraine genetics are presented. Regarding pathophysiology there are very recent insights regarding the role of the hypothalamus during prodromal phase and the interplay of brain-stem and hypothalamus during the attack...
June 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28641772/susac-syndrome-a-differential-diagnosis-of-white-matter-lesions
#18
Mariano Marrodan, Jorge Correale, Lucas Alessandro, Mariela Amaya, Maria Eugenia Fracaro, Alejandro Alfredo Köhler, Marcela Fiol
INTRODUCTION: Susac Syndrome is an autoimmune endotheliopathy affecting capillaries and precapillary arterioles of the brain, inner ear and retina. The classic symptom triad includes visual disturbances, hypoacusia, and encephalopathy, but is rarely fully manifest at onset. The syndrome typically follows an active fluctuating monophasic course. Typical imaging findings on brain magnetic resonance show central fiber microischemias/microinfarctions of the corpus callosum known as "snow balls", as well as lineal infarcts and upper callosal fiber involvement...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641766/amyloid-pet-in-pseudotumoral-multiple-sclerosis
#19
Jordi A Matías-Guiu, María Nieves Cabrera-Martín, Ana Cortés-Martínez, Vanesa Pytel, Teresa Moreno-Ramos, Celia Oreja-Guevara, José Luis Carreras, Jorge Matías-Guiu
BACKGROUND: Pseudotumoral multiple sclerosis is a rare form of demyelinating disease of the central nervous system. Positron emission tomography (PET) using amyloid-tracers has also been suggested as a marker of damage in white matter lesions in multiple sclerosis due to the nonspecific uptake of these tracers in white matter. METHOD: We present the case of a 59 year-old woman with a pathological-confirmed pseudotumoral multiple sclerosis, who was studied with the amyloid tracer (18)F-florbetaben...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28638989/parietal-white-matter-lesions-in-alzheimer-s-disease-are-associated-with-cortical-neurodegenerative-pathology-but-not-with-small-vessel-disease
#20
Kirsty E McAleese, Lauren Walker, Sophie Graham, Elisa L J Moya, Mary Johnson, Daniel Erskine, Sean J Colloby, Madhurima Dey, Carmen Martin-Ruiz, John-Paul Taylor, Alan J Thomas, Ian G McKeith, Charles De Carli, Johannes Attems
Cerebral white matter lesions (WML) encompass axonal loss and demyelination, and the pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However, WML may also result from the activation of Wallerian degeneration as a consequence of cortical Alzheimer's disease (AD) pathology, i.e. hyperphosphorylated tau (HPτ) and amyloid-beta (Aβ) deposition. WML seen in AD have a posterior predominance compared to non-demented individuals but it is unclear whether the pathological and molecular signatures of WML differ between these two groups...
June 21, 2017: Acta Neuropathologica
keyword
keyword
50264
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"