keyword
MENU ▼
Read by QxMD icon Read
search

uterotonics

keyword
https://www.readbyqxmd.com/read/29141679/intramuscular-oxytocin-versus-intravenous-oxytocin-to-prevent-postpartum-haemorrhage-at-vaginal-delivery-labor-trial-study-protocol-for-a-randomised-controlled-trial
#1
Nita Adnan, Fiona Boland, Deirdre J Murphy
BACKGROUND: Primary postpartum haemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality worldwide. The most common cause of primary PPH is uterine atony. Atonic PPH rates are increasing in developed countries despite routine active management of the third stage of labour. In less-developed countries, primary PPH remains the leading cause of maternal death. Although the value of routine oxytocics in the third stage of labour has been well established, there is inconsistent practice in the choice of agent and route of administration...
November 15, 2017: Trials
https://www.readbyqxmd.com/read/29132342/a-low-cost-uterine-balloon-tamponade-for-management-of-postpartum-hemorrhage-modeling-the-potential-impact-on-maternal-mortality-and-morbidity-in-sub-saharan-africa
#2
Tara Herrick, Mercy Mvundura, Thomas F Burke, Elizabeth Abu-Haydar
BACKGROUND: Postpartum hemorrhage (PPH) is the leading cause of maternal deaths worldwide. This study sought to quantify the potential health impact (morbidity and mortality reductions) that a low-cost uterine balloon tamponade (UBT) could have on women suffering from uncontrolled PPH due to uterine atony in sub-Saharan Africa. METHODS: The Maternal and Neonatal Directed Assessment of Technology (MANDATE) model was used to estimate maternal deaths, surgeries averted, and cases of severe anemia prevented through UBT use among women with PPH who receive a uterotonic drug but fail this therapy in a health facility...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29122802/emergency-obstetric-care-provision-in-southern-ethiopia-a-facility-based-survey
#3
Mitchell Windsma, Tienke Vermeiden, Floris Braat, Andualem Mengistu Tsegaye, Asheber Gaym, Thomas van den Akker, Jelle Stekelenburg
OBJECTIVES: To assess the provision of basic emergency obstetric and newborn care (BEmONC), knowledge of high-risk pregnancies and referral capacity at health centres in Southern Ethiopia. DESIGN: A facility-based survey, using an abbreviated version of the Averting Maternal Death and Disability needs assessment tool for emergency obstetric and newborn care. Modules included infrastructure, staffing, number of deliveries, maternal and perinatal mortality, BEmONC signal functions, referral capacity and knowledge of risk factors in pregnancy...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29073923/achieving-community-based-postpartum-follow-up-in-eastern-uganda-the-field-experience-from-the-mamamiso-study-on-antenatal-distribution-of-misoprostol
#4
James Ditai, Laura J Frye, Jill Durocher, Meagan E Byrne, Sam Ononge, Beverly Winikoff, Andrew D Weeks
BACKGROUND: Advance provision of misoprostol to women during antenatal care aims to achieve broader access to uterotonics for the prevention of postpartum hemorrhage. Studies of this community-based approach usually involve antenatal education as well as timely postpartum follow-up visits to confirm maternal and neonatal outcomes. The MamaMiso study in Mbale, Uganda sought to assess the feasibility of conducting follow-up visits in the postpartum period following advance provision of misoprostol for postpartum hemorrhage prevention...
October 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29037097/obstetrical-and-neonatal-outcomes-of-pregnancies-complicated-by-endometriosis
#5
Anat Shmueli, Lina Salman, Liran Hiersch, Eran Ashwal, Eran Hadar, Arnon Wiznitzer, Yariv Yogev, Amir Aviram
OBJECTIVE: Endometriosis is defined as the presence of endometrial-like tissue outside the uterus, associated with pelvic pain and subfertility, affecting 0.6-10% of the general female population. The association between endometriosis and obstetrical outcomes is not well established. We aimed to evaluate whether endometriosis is associated with a higher incidence of obstetrical and neonatal complications. STUDY DESIGN: A retrospective cohort study of all deliveries in a university-affiliated tertiary hospital (2007-2014)...
October 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29033832/cyclotides-isolated-from-an-ipecac-root-extract-antagonize-the-corticotropin-releasing-factor-type-1-receptor
#6
Mohsen Fahradpour, Peter Keov, Carlotta Tognola, Estela Perez-Santamarina, Peter J McCormick, Alireza Ghassempour, Christian W Gruber
Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular. Previously the cyclotide kalata B7 was identified to modulate the human oxytocin and vasopressin G protein-coupled receptors (GPCRs), providing molecular validation of the plants' uterotonic properties and further establishing cyclotides as valuable source for GPCR ligand design. In this study we screened a cyclotide extract derived from the root powder of the South American medicinal plant ipecac (Carapichea ipecacuanha) for its GPCR modulating activity of the corticotropin-releasing factor type 1 receptor (CRF1R)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29027315/cost-effectiveness-analysis-of-carbetocin-during-cesarean-section-in-a-high-volume-maternity-unit
#7
Hian Yan Voon, Asrul A Shafie, Mohamad A Bujang, Haris N Suharjono
AIM: To evaluate the cost effectiveness of carbetocin compared to oxytocin when used as prophylaxis against post-partum hemorrhage (PPH) during cesarean deliveries. METHODS: A systematic review of the literature was performed to identify randomized controlled trials that compared the use of carbetocin to oxytocin in the context of cesarean deliveries. Cost effectiveness analysis was then performed using secondary data from the perspective of a maternity unit within the Malaysian Ministry of Health, over a 24 h time period...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29025850/protocol-for-a-pilot-randomised-double-blinded-placebo-controlled-trial-of-prophylactic-use-of-tranexamic-acid-for-preventing-postpartum-haemorrhage-tapph-1
#8
Asim Alam, Ameya Bopardikar, Shelly Au, Jon Barrett, Jeannie Callum, Alex Kiss, Stephen Choi
INTRODUCTION: Postpartum haemorrhage (PPH) is the leading cause of maternal morbidity and mortality worldwide. Despite the availability of multiple uterotonic agents, the incidence of PPH continues to rise. Tranexamic acid (TXA) has been shown to be a safe, effective and inexpensive therapeutic option for the treatment of PPH, however, its use prophylactically in mitigating the risk of PPH is unknown. This pragmatic randomised prospective trial assesses the feasibility and safety of administering TXA at the time of delivery for the prevention of PPH...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28988745/moving-beyond-uterotonics-for-the-treatment-of-postpartum-hemorrhage-lessons-from-the-woman-study
#9
Andrew D Weeks, Andre Lalonde
No abstract text is available yet for this article.
October 4, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28954603/matrix-metalloprotease-1-and-elastase-are-novel-uterotonic-agents-acting-through-protease-activated-receptor-1
#10
Scott W Walsh, William H Nugent, Anna V Solotskaya, Charles D Anderson, John R Grider, Jerome F Strauss
Matrix metalloproteinase-1 (MMP-1) and neutrophil elastase are proteolytic enzymes involved in tissue remodeling, but a role for them as uterotonic agents has not been considered. However, both these proteases activate protease-activated receptor 1 (PAR-1) that mediates thrombin-induced contractions. Matrix metalloproteinase-1 and elastase are products of neutrophils that infiltrate intrauterine tissues at the time of labor, so we tested the hypothesis that these proteases might be novel uterotonic agents acting via PAR-1...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28916261/differential-involvement-of-l-and-t-type-ca-2-channels-store-operated-calcium-channel-trpc-and-rho-kinase-signaling-pathway-s-in-pgf2%C3%AE-induced-contractions-in-myometrium-of-non-pregnant-and-pregnant-buffaloes-bubalus-bubalis
#11
Abhishek Sharma, Udayraj P Nakade, Pooja Jaitley, Vipin Sharma, Soumen Choudhury, Satish Kumar Garg
This study unravels the differential involvement of calcium signaling pathway(s) in PGF2α-induced contractions in myometrium of non-pregnant and pregnant buffaloes. Compared to the myometrium of pregnant animals, myometrium of non-pregnant buffaloes was more sensitive to PGF2α-induced contractile effect as manifested by the changes in mean integral tension (MIT) and tonicity. However, phasic contraction was significantly more in myometrium of pregnant animals. The uterotonic effect of PGF2α was dependent on extracellular Ca(2+) and its influx through nifedipine-sensitive L-type Ca(2+) channels both in non-pregnant and pregnant animals, but T-type Ca(2+) channels play an additional role during pregnancy...
September 12, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28893211/clinical-performance-and-patient-outcome-after-simulation-based-training-in-prevention-and-management-of-postpartum-haemorrhage-an-educational-intervention-study-in-a-low-resource-setting
#12
Ellen Nelissen, Hege Ersdal, Estomih Mduma, Bjørg Evjen-Olsen, Jos Twisk, Jacqueline Broerse, Jos van Roosmalen, Jelle Stekelenburg
BACKGROUND: Postpartum haemorrhage (PPH) is a major cause of maternal mortality. Prevention and adequate treatment are therefore important. However, most births in low-resource settings are not attended by skilled providers, and knowledge and skills of healthcare workers that are available are low. Simulation-based training effectively improves knowledge and simulated skills, but the effectiveness of training on clinical behaviour and patient outcome is not yet fully understood. The aim of this study was to assess the effect of obstetric simulation-based training on the incidence of PPH and clinical performance of basic delivery skills and management of PPH...
September 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28888864/predictors-of-supplementation-for-breastfed-babies-in-a-baby-friendly-hospital
#13
Stefanie Kalmakoff, Andrew Gray, Sally Baddock
PROBLEM: Supplementation of breastfed babies is common during the hospital stay. BACKGROUND: The Baby Friendly Hospital Initiative (BFHI) optimises practices to support exclusive breastfeeding, yet supplementation is still prevalent. OBJECTIVE: To determine predictors for supplementation in a cohort of breastfed babies in a Baby-Friendly hospital. METHODS: Electronic hospital records of 1530 healthy term or near term singleton infants and their mothers were examined retrospectively and analysed to identify factors associated with in-hospital supplementation using Poisson regression (unadjusted and adjusted)...
September 6, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28884585/analysis-of-the-cost-effectiveness-of-carbetocin-for-the-prevention-of-hemorrhage-following-cesarean-delivery-in-ecuador
#14
Aquiles Rodrigo Henríquez-Trujillo, Ruth Alicia Lucio-Romero, Kerlly Bermúdez-Gallegos
AIM: To compare the cost of carbetocin with that of oxytocin for the prevention and management of hemorrhage following cesarean delivery in Ecuador. MATERIALS & METHODS: We developed a decision tree based cost-effectiveness model to compare carbetocin with oxytocin in the prevention of hemorrhage following cesarean delivery in Ecuador. Our model was run from a third party payer perspective and was validated by local experts in the field. The efficacy of the interventions was determined based on a systematic review of the literature...
September 8, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28875743/different-routes-and-forms-of-uterotonics-for-treatment-of-retained-placenta-methodological-issues
#15
Ahmed M Abbas
No abstract text is available yet for this article.
September 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28864699/uterine-balloon-tamponade-as-an-adjunct-to-misoprostol-for-the-treatment-of-uncontrolled-postpartum-haemorrhage-a-randomised-controlled-trial-in-benin-and-mali
#16
Alexandre Dumont, Cécile Bodin, Benjamin Hounkpatin, Thomas Popowski, Mamadou Traoré, René Perrin, Patrick Rozenberg
OBJECTIVE: To assess the effectiveness of low-cost uterine tamponade as an adjunct to misoprostol for the treatment of uncontrolled postpartum haemorrhage (PPH) in low-resource settings. DESIGN: Randomised controlled trial. SETTING: Seven healthcare facilities in Cotonou, Benin and Bamako, Mali. POPULATION: Women delivering vaginally who had clinically diagnosed PPH that was suspected to be due to uterine atony, who were unresponsive to oxytocin and who needed additional uterotonics...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28858899/patients-undergoing-cesarean-delivery-after-exposure-to-oxytocin-during-labor-require-higher-postpartum-oxytocin-doses
#17
Amanda Foley, Ashley Gunter, Kenneth J Nunes, Sajid Shahul, Barbara M Scavone
BACKGROUND: Experts recommend postpartum oxytocin to prevent uterine atony and hemorrhage, but oxytocin may be associated with dose-dependent adverse effects, and the correct dose of postpartum oxytocin has yet to be determined. The effective dose in 90% of patients (ED90) of oxytocin after cesarean delivery may be higher in patients exposed to oxytocin during labor compared to patients unexposed. We therefore undertook this study to compare postpartum oxytocin requirements in patients exposed to oxytocin prior to cesarean delivery versus those not exposed, when all were treated according to a specific institutional protocol...
August 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28797187/a-survey-of-physicians-attitudes-toward-uterotonic-administration-in-parturients-undergoing-cesarean-section
#18
Sharon Orbach-Zinger, Sharon Einav, Assaf Yona, Leonid A Eidelman, Shia Fein, Atara Davis, Alexander Ioscovich
OBJECTIVE: Oxytocin is globally accepted as first-line treatment for prevention of post-partum hemorrhage. However, there is wide variability in its use in clinical practice. In this study, we aimed to evaluate obstetricians and anesthesiologists attitudes towards uterotonic practices in Israel. STUDY DESIGN: The current survey was designed to study the preferences of obstetricians and anesthesiologists in seven University hospitals regarding the type, dose, and mode of administration of uterotonic drugs, as well as their knowledge regarding the side effects of these drugs...
August 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28720114/effects-of-the-equip-quasi-experimental-study-testing-a-collaborative-quality-improvement-approach-for-maternal-and-newborn-health-care-in-tanzania-and-uganda
#19
P Waiswa, F Manzi, G Mbaruku, A K Rowe, M Marx, G Tomson, T Marchant, B A Willey, J Schellenberg, S Peterson, C Hanson
BACKGROUND: Quality improvement is a recommended strategy to improve implementation levels for evidence-based essential interventions, but experience of and evidence for its effects in low-resource settings are limited. We hypothesised that a systemic and collaborative quality improvement approach covering district, facility and community levels, supported by report cards generated through continuous household and health facility surveys, could improve the implementation levels and have a measurable population-level impact on coverage and quality of essential services...
July 18, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28707488/efficacy-of-oxytocin-versus-carbetocin-in-prevention-of-postpartum-hemorrhage-after-cesarean-section-under-general-anesthesia-a-prospective-randomized-clinical-trial
#20
Robabeh Taheripanah, Amal Shoman, Mohammad Ali Karimzadeh, Marzieh Zamaniyan, Narges Malih
OBJECTIVE: To compare the use of carbetocin and oxytocin in the prevention of postpartum hemorrhage after cesarean section. METHODS: The present study was a prospective double-blind randomized controlled clinical trial performed in two university-based hospitals in Tehran, Iran. Two hundred and twenty women with the gestational age of more than 37 weeks, who needed cesarean operation, participated in the study. Patients were assigned to receive either a single 100 μg IV dose of carbetocin or a standard 30-international unit IV infusion of oxytocin during 2 h after delivery of placenta...
July 25, 2017: Journal of Maternal-fetal & Neonatal Medicine
keyword
keyword
50257
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"