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Migraine with aura

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https://www.readbyqxmd.com/read/27919769/transcriptomic-changes-in-rat-cortex-and-brainstem-after-cortical-spreading-depression-with-or-without-pre-treatment-with-migraine-prophylactic-drugs
#1
Cèlia Sintas, Noèlia Fernàndez-Castillo, Marta Vila-Pueyo, Patricia Pozo-Rosich, Alfons Macaya, Bru Cormand
: Migraine with aura is a subtype of migraine consisting of neurological disturbances that usually precede headache. Cortical spreading depression (CSD) is the likely pathophysiological correlate of the aura phase of migraine, found in common and rare forms of migraine, such as familial hemiplegic migraine (FHM). CSD is a depolarization wave that propagates across the cerebral gray matter transiently suppressing neuronal activity. Prophylactic treatments for migraine, such as topiramate (TPM) or valproate (VPA), reduce the number of CSD events...
December 2, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27919019/induction-of-calcitonin-gene-related-peptide-expression-in-rats-by-cortical-spreading-depression
#2
Yan Wang, Anne E Tye, Junli Zhao, Dongqing Ma, Ann C Raddant, Fan Bu, Benjamin L Spector, Nolan K Winslow, Minyan Wang, Andrew F Russo
OBJECTIVE: The neuropeptide calcitonin gene-related peptide (CGRP) has now been established as a key player in migraine. However, the mechanisms underlying the reported elevation of CGRP in the serum and cerebrospinal fluid of some migraineurs are not known. A candidate mechanism is cortical spreading depression (CSD), which is associated with migraine with aura and traumatic brain injury. The aim of this study was to investigate whether CGRP gene expression may be induced by experimental CSD in the rat cerebral cortex...
November 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919014/a-novel-scn1a-mutation-identified-in-a-chinese-family-with-familial-hemiplegic-migraine-a-case-report
#3
Yang Zhang, Ning Chen, Muke Zhou, Jian Guo, Jiang Guo, Li He
BACKGROUND: Familial hemiplegic migraine (FHM) is a rare type of migraine with aura that is characterized by transient hemiparesis. Mutations in three genes (CACNA1A, ATP1A2, and SCN1A) have been found to cause FHM. Among these, nine SCN1A gene mutations were reported to cause familial hemiplegic migraine type 3 (FHM3). However, none of them was reported in China. METHOD: The clinical manifestations of a Chinese FHM family were recorded and all coding exons and flanking intronic regions of the CACNA1A, ATP1A2, and SCN1A genes were tested for mutations...
November 8, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27917786/structural-changes-in-the-cerebrum-cerebellum-and-corpus-callosum-in-migraine-patients
#4
Berin T Demir, Nezihe A Bayram, Zübeyde Ayturk, Hüsamettin Erdamar, Pelin Seven, Ayşegül Calp, Merve Sazak, Hatice G Ceylan
PURPOSE: The purpose of this study was to demonstrate the relationship among the cerebrum, cerebellum and corpus callosum in migraine patients. METHODS: This work was conducted with cooperation of the Turgut Özal Medical Faculty, Department of Anatomy and Neurology. Migraine patients were divided into four groups: new patients; 1-5 years; 5-10 years; and, more than 10 years. All patients (n=75) and control subjects (n=20) underwent Magnetic Resonance Imaging (MRI) and brain images were processed by ONIS and Image J...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27910096/de-novo-migraine-with-aura-after-surgical-repair-of-aortic-coarctation
#5
Yuji Kato, Takeshi Hayashi, Toshiki Kobayashi, Ayumu Masuoka, Tetsuya Abe, Takahiro Hasebe, Norio Tanahashi, Masaki Takao
Coarctation of the aorta (CoA) is reported to be associated with an increased risk for migraine. We describe here the case of a 13-year-old female patient who presented migraine with aura after surgical repair of CoA with a stent. As possible reasons for her condition, we postulate host responses to stent placement and/or disturbed cerebral autoregulation related to intracranial hypertension before the surgical repair and hypotension afterward, leading to hypoperfusion. This case demonstrates that de novo migraine with aura can occur after surgical repair of CoA and should be recognized as a potential complication...
December 2, 2016: Headache
https://www.readbyqxmd.com/read/27910087/menstrual-migraine-and-treatment-options-review
#6
REVIEW
Kasra Maasumi, Stewart J Tepper, Jennifer S Kriegler
OBJECTIVE: A review of treatment options for menstrual migraine. BACKGROUND: Migraine affects ∼30 million people in the US. A subset of female migraineurs have migraines that are mainly associated with menstruation. Menstrual migraine (MM) is divided into pure MM and menstrually related migraine. Pure MM attacks occur only with menstruation and have a prevalence of 1%. Menstrually related migraine has a prevalence of 6-7%, and occurs both during menstruation as well as during the rest of the cycle...
December 2, 2016: Headache
https://www.readbyqxmd.com/read/27896587/psychological-and-behavioral-issues-in-the-management-of-migraine-in-children-and-adolescents
#7
REVIEW
William Qubty, Amy A Gelfand
PURPOSE OF REVIEW: It is sometimes assumed that children and adolescents with migraine have a psychiatric or behavioral comorbidity, a belief that can be stigmatizing. This review will examine the recent literature addressing this area to determine if pediatric and adolescent migraineurs are at increased risk for psychiatric comorbidity and to discuss management strategies. RECENT FINDINGS: A large systematic review of pediatric and adolescent studies concluded anxiety and depression were not associated with onset of recurrent headaches...
December 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/27895449/cadasil-presenting-with-spontaneous-intracerebral-hemorrhage-report-of-a-case-and-description-of-the-first-family-in-northern-greece
#8
I Koutroulou, T Karapanayiotides, N Grigoriadis, D Karacostas
INTRODUCTION: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), the most common inherited cause of stroke and dementia in adults, has been described in six Greek families. Common presenting manifestations include migraine with aura, brain ischemia, mood disorders and cognitive decline. Spontaneous intracerebral hemorrhage (SICH) rarely occurs in CADASIL and only exceptionally as the first clinical manifestation. CASE DESCRIPTION: We have previously reported the sixth Greek family with CADASIL and in particular, two brothers in whom the genetic testing documented a classic mutation of the NOTCH3 gene (Arg169Cys)...
January 2016: Hippokratia
https://www.readbyqxmd.com/read/27888414/structural-brain-abnormalities-in-patients-with-vestibular-migraine
#9
Roberta Messina, Maria A Rocca, Bruno Colombo, Roberto Teggi, Andrea Falini, Giancarlo Comi, Massimo Filippi
New advances in understanding the pathophysiology of vestibular migraine (VM) have suggested a large overlap between migraine and vestibular pathways. We explored the regional distribution of gray (GM) and white matter (WM) abnormalities in VM patients in comparison to migraine patients with (MWA) and without aura (MWoA) and their correlations with patients' clinical manifestations. Using a 3.0 Tesla scanner, brain T2-weighted and 3D T1-weighted MRI scans were acquired from 19 VM, 19 MWA, 19 MWoA and 20 age-matched controls...
November 25, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27879227/correlation-between-cvemp-and-abr-for-the-evaluation-of-vestibular-migraine
#10
Mehmet Sürmeli, Reyhan Sürmeli, İldem Deveci, Serap Önder, Ayşe Destina Yalçın, Çağatay Oysu
OBJECTIVE: Vestibular migraine (VM) is a clinical condition characterized by temporal overlap between vestibular symptoms and migraine. In this study, we aimed to determine the changes in vestibular myogenic potential (cVEMP) and auditory brainstem response (ABR) in patients with VM and migraine. MATERIALS AND METHODS: A total of 86 participants with no hearing loss or additional disease between the ages of 18 and 45 were enrolled in three different groups: group 1, VM; group 2, migraine without aura; and group 3, healthy controls...
November 23, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27873123/vestibular-migraine-in-children-and-adolescents
#11
REVIEW
Thyra Langhagen, Mirjam N Landgraf, Doreen Huppert, Florian Heinen, Klaus Jahn
PURPOSE OF REVIEW: The goal of this review is to provide an actualized overview on vestibular migraine in childhood and adolescence, with focus on the epidemiology and clinical presentation as well as its treatment. RECENT FINDINGS: Vertigo spells in childhood can evolve into other periodic syndromes and/or migraine types and persist even into adulthood. Vestibular migraine (VM) and benign paroxysmal vertigo are the most common causes of vertigo in children and adolescents...
December 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/27873122/how-well-does-the-ichd-3-beta-help-in-real-life-migraine-diagnosis-and-management
#12
REVIEW
Sait Ashina, Jes Olesen, Richard B Lipton
Classification has played a major role in the diagnosis of primary headache conditions including migraine with and without aura. With many updates and changes, the International Classification of Headache Disorders (ICHD)-3 beta is currently considered as the gold standard for classification of migraine and other headaches. Correct diagnosis of migraine and its subtypes is a first step toward appropriate treatment and crucial to minimizing disability and optimizing health-related quality of life. The ICHD-3 beta version represents the state of the art in migraine diagnosis but is expected to evolve as biological knowledge advances...
December 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/27861837/cardiovascular-events-conditions-and-procedures-among-people-with-episodic-migraine-in-the-us-population-results-from-the-american-migraine-prevalence-and-prevention-ampp-study
#13
Dawn C Buse, Michael L Reed, Kristina M Fanning, Tobias Kurth, Richard B Lipton
BACKGROUND: Though migraine, particularly migraine with aura, is a cardiovascular (CV) risk factor, the scope and distribution of cardiovascular disease in representative samples of people with migraine are not known. This is important because many widely used acute migraine treatments, including triptans, ergot alkaloids, and nonsteroidal anti-inflammatory drugs, carry precautions, warnings, or contraindications for use in persons with CV disease. OBJECTIVES: To assess the scope and distribution of cardiovascular events, conditions, and procedures in persons with episodic migraine in a representative sample of the US population, using data from the American Migraine Prevalence and Prevention (AMPP) Study...
November 12, 2016: Headache
https://www.readbyqxmd.com/read/27837002/safety-of-domperidone-in-treating-nausea-associated-with-dihydroergotamine-infusion-and-headache
#14
Nathaniel M Robbins, Hiroyuki Ito, Melvin M Scheinman, Peter J Goadsby
OBJECTIVE: To determine the safety of domperidone in the treatment of nausea associated with dihydroergotamine (DHE) infusion and headache. METHODS: We audited our use of domperidone for the inpatient management of nausea, focusing on known safety concerns, particularly potential cardiac arrhythmias. RESULTS: We reviewed 103 consecutive admissions of 90 patients admitted for IV DHE by infusion. Most admissions were to treat chronic migraine with (n = 53) or without (n = 46) aura...
November 11, 2016: Neurology
https://www.readbyqxmd.com/read/27836433/sex-differences-in-the-epidemiology-clinical-features-and-pathophysiology-of-migraine
#15
REVIEW
Kjersti Grøtta Vetvik, E Anne MacGregor
Migraine is two to three times more prevalent in women than men, and women report a longer attack duration, increased risk of headache recurrence, greater disability, and a longer period of time required to recover. Conditions recognised to be comorbid with migraine include asthma, anxiety, depression, and other chronic pain conditions, and these comorbidities add to the amount of disability in both sexes. Migraine-specifically migraine with aura-has been identified as a risk factor for vascular disorders, particularly in women, but because of the scarcity of data, the comparative risk in men has yet to be established...
November 8, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27832651/assessment-of-migraine-history-in-patients-with-a-transient-ischemic-attack-or-stroke-validation-of-a-migraine-screener-for-stroke
#16
Daphne van der Willik, Nadine Pelzer, Ale Algra, Gisela M Terwindt, Marieke J H Wermer
BACKGROUND: To investigate the connection between migraine and stroke, a reliable screening tool to gather information about a person's migraine history is crucial. We studied the test-characteristics of a 5-question Migraine Screener for Stroke (MISS). METHODS: We included a random sample of patients with a transient ischemic attack or stroke who answered the MISS questionnaire when they were admitted to our hospital. After discharge, a semi-structured telephone interview was conducted to validate the migraine diagnosis with the International Classification of Headache Disorders, second-edition criteria as gold standard...
November 11, 2016: European Neurology
https://www.readbyqxmd.com/read/27826448/a-feasible-repetitive-transcranial-magnetic-stimulation-clinical-protocol-in-migraine-prevention
#17
Shawn Zardouz, Lei Shi, Albert Leung
OBJECTIVE: This case series was conducted to determine the clinical feasibility of a repetitive transcranial magnetic stimulation protocol for the prevention of migraine (with and without aura). METHODS: Five patients with migraines underwent five repetitive transcranial magnetic stimulation sessions separated in 1- to 2-week intervals for a period of 2 months at a single tertiary medical center. Repetitive transcranial magnetic stimulation was applied to the left motor cortex with 2000 pulses (20 trains with 1s inter-train interval) delivered per session, at a frequency of 10 Hz and 80% resting motor threshold...
2016: SAGE open medical case reports
https://www.readbyqxmd.com/read/27818813/familial-hemiplegic-migraine-with-severe-attacks-a-new-report-with-atp1a2-mutation
#18
E Martínez, R Moreno, L López-Mesonero, I Vidriales, M Ruiz, A L Guerrero, J J Tellería
Introduction. Familial hemiplegic migraine (FHM) is a rare disorder characterized by migraine attacks with motor weakness during the aura phase. Mutations in CACNA1A, ATP1A2, SCN1A, and PRRT2 genes have been described. Methods. To describe a mutation in ATP1A2 gene in a FHM case with especially severe and prolonged symptomatology. Results. 22-year-old woman was admitted due to migraine-type headache and sudden onset of right-sided weakness and aphasia; she had similar episodes in her childhood. Her mother was diagnosed with hemiplegic migraine without genetic confirmation...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27807767/resting-state-eeg-power-and-coherence-vary-between-migraine-phases
#19
Zehong Cao, Chin-Teng Lin, Chun-Hsiang Chuang, Kuan-Lin Lai, Albert C Yang, Jong-Ling Fuh, Shuu-Jiun Wang
BACKGROUND: Migraine is characterized by a series of phases (inter-ictal, pre-ictal, ictal, and post-ictal). It is of great interest whether resting-state electroencephalography (EEG) is differentiable between these phases. METHODS: We compared resting-state EEG energy intensity and effective connectivity in different migraine phases using EEG power and coherence analyses in patients with migraine without aura as compared with healthy controls (HCs). EEG power and isolated effective coherence of delta (1-3...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27790126/hemiplegic-migraine-presenting-with-prolonged-somnolence-a-case-report
#20
Christian Saleh, Geneviève Pierquin, Stefan Beyenburg
Hemiplegic migraine is a rare and complex disease, characterized by migraine with a reversible motor aura. Hemiplegic migraine can be easily misdiagnosed at its first presentation with an atypical severe form of migraine, a stroke, multiple sclerosis, metabolic disorders, conversion disorder or an epilepsy. We present the case of a young 24-year-old male patient, who since the age of 4 years had been having multiple episodes of migraine associated with hemiparesis, paraesthesia, prolonged somnolence, aphasia and confusion...
September 2016: Case Reports in Neurology
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