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Migraine with aura

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https://www.readbyqxmd.com/read/28193695/cortical-spreading-depression-closes-the-paravascular-space-and-impairs-glymphatic-flow-implications-for-migraine-headache
#1
Aaron J Schain, Agustin Melo, Andrew M Strassman, Rami Burstein
Functioning of the glymphatic system, a network of paravascular tunnels through which cortical interstitial solutes are cleared from the brain, has recently been linked to sleep and traumatic brain injury, both of which can affect the progression of migraine. This led us to investigate the connection between migraine and the glymphatic system. Taking advantage of a novel in vivo method we developed to visualize the PVS in naïve uninjected mice using 2-photon microscopy, we show that a single wave of cortical spreading depression (CSD), an animal model of migraine aura, induces a rapid and nearly complete closure of the paravascular space (PVS) around surface as well as penetrating cortical arteries and veins lasting several minutes, and gradually recovering over 30 min...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28184165/visual-spatial-training-efficacy-in-children-affected-by-migraine-without-aura-a-multicenter-study
#2
Francesco Precenzano, Maria Ruberto, Lucia Parisi, Margherita Salerno, Agata Maltese, Beatrice Gallai, Rosa Marotta, Serena Marianna Lavano, Francesco Lavano, Michele Roccella
Routinely in the clinical practice, children affected by migraine without aura (MwA) tend to exhibit severe and persistent difficulties within cognitive processes such as attention, memory, and visual-motor integration (VMI) skills. The aim of this study was to assess the visual-spatial and visual-motor abilities among a sample of children with MwA and the effects of a specific computerized training. The study population was composed of 84 patients affected by MwA (39 girls and 45 boys; mean age: 8.91±2.46 years), and they were randomly divided into two groups (group A and group B) comparable for age (P=0...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28181217/hypercoagulability-and-migraine
#3
Gretchen E Tietjen, Stuart A Collins
BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated estrogen levels, endothelial activation and dysfunction, antiphospholipid antibodies (aPL), deficiency of coagulation inhibitors, and presence of certain genetic polymorphisms...
February 9, 2017: Headache
https://www.readbyqxmd.com/read/28159058/migraine-and-cardiovascular-disease-in-women
#4
REVIEW
Katie M Linstra, Khatera Ibrahimi, Gisela M Terwindt, Marieke J H Wermer, Antoinette MaassenVanDenBrink
Migraine is responsible for high rates of disability. In addition, it is associated with an increased risk of cardiovascular disease. This association is not limited to the brain in the form of stroke, but includes cardiac ischemia. The increased risk is most consistently described in the female population and in particular for migraine with aura. This article reviews the current knowledge on migraine and the associated risk of cardiovascular disease, with a focus on female-specific factors.
March 2017: Maturitas
https://www.readbyqxmd.com/read/28157621/analysis-of-the-upper-cervical-spine-stiffness-during-axial-rotation-a-comparative-study-among-patients-with-tension-type-headache-or-migraine-and-asymptomatic-subjects
#5
P-M Dugailly, A Decuyper, W Salem, A De Boe, G V Espí-López, Y Lepers
BACKGROUND: Many studies reported the implication of the cervical musculoskeletal system in patients with tension type headache and migraine. The objective of this study is to investigate the upper cervical spine stiffness features in axial rotation among headache patients in comparison with a healthy population. METHODS: 48 subjects including 30 migraine patients with/without aura and 18 patients with tension-type headache, aged between 18 and 60years (mean 36, SD 11years) have been evaluated...
January 27, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28154971/the-sensorimotor-network-dysfunction-in-migraineurs-without-aura-a-resting-state-fmri-study
#6
Jilei Zhang, Jingjing Su, Mengxing Wang, Ying Zhao, Qi-Ting Zhang, Qian Yao, Haifeng Lu, Hui Zhang, Ge-Fei Li, Yi-Lan Wu, Yi-Sheng Liu, Feng-Di Liu, Mei-Ting Zhuang, Yan-Hui Shi, Tian-Yu Hou, Rong Zhao, Yuan Qiao, Jianqi Li, Jian-Ren Liu, Xiaoxia Du
Migraine is a common recurrent neurological disorder combining nausea, vomiting, and hypersensitivities to visual, auditory, olfactory and somatosensory stimuli. However, the dysfunction of the sensorimotor network in migraineurs has not been well clarified. In the present study, we evaluated the dysfunction of the sensorimotor network in 30 migraineurs without aura and in 31 controls by combining regional homogeneity (ReHo), amplitudes of low-frequency fluctuation (ALFF) and degree centrality (DC) analysis methods based on resting-state fMRI...
February 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28145727/estrogen-dependent-effects-of-5-hydroxytryptophan-on-cortical-spreading-depression-in-rat-modelling-the-serotonin-ovarian-hormone-interaction-in-migraine-aura
#7
Virginie Chauvel, Sylvie Multon, Jean Schoenen
Background Cortical spreading depression (CSD) is the likely culprit of the migraine aura. Migraine is sexually dimorphic and thought to be a "low 5-HT" condition. We sought to decipher the interrelation between serotonin, ovarian hormones and cortical excitability in a model of migraine aura. Methods Occipital KCl-induced CSDs were recorded for one hour at parieto-occipital and frontal levels in adult male (n = 16) and female rats (n = 64) one hour after intraperitoneal (i.p.) injection of 5-hydroxytryptophan (5-HTP) or NaCl...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28130625/endovascular-thrombectomy-and-post-procedural-headache
#8
Sabrina Khan, Faisal Mohammad Amin, Markus Holtmannspötter, Klaus Hansen, Anna Maria Florescu, Zainab Fakhril-Din, Julie Falkenberg Petersen, Hashmat Ghanizada, Cenk Ayata, David Gaist, Messoud Ashina
BACKGROUND: We investigated the prevalence of post-procedural headache in patients who have undergone thrombectomy for ischemic stroke, and correlated history of migraine with risk of peri-procedural complications. A total of 314 patients underwent thrombectomy at the Danish National Hospital from January 2012 to December 2014. Eligible subjects were phone-interviewed using a purpose-developed semi-structured questionnaire according to the International Classification of Headache Disorders 3, beta version criteria...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28128464/a-review-of-hormonal-contraceptives-and-migraine-with-aura-is-there-still-a-risk
#9
Lynda J Krasenbaum
No abstract text is available yet for this article.
February 2017: Headache
https://www.readbyqxmd.com/read/28124204/interictal-brain-activity-differs-in-migraine-with-and-without-aura-resting-state-fmri-study
#10
Péter Faragó, Bernadett Tuka, Eszter Tóth, Nikoletta Szabó, András Király, Gergő Csete, Délia Szok, János Tajti, Árpád Párdutz, László Vécsei, Zsigmond Tamás Kincses
BACKGROUND: Migraine is one of the most severe primary headache disorders. The nature of the headache and the associated symptoms during the attack suggest underlying functional alterations in the brain. In this study, we examined amplitude, the resting state fMRI fluctuation in migraineurs with and without aura (MWA, MWoA respectively) and healthy controls. METHODS: Resting state functional MRI images and T1 high-resolution images were acquired from all participants...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28122382/auditory-processing-in-children-with-migraine-a-controlled-study
#11
Larissa Mendonça Agessi, Thaís Rodrigues Villa, Deusvenir de Souza Carvalho, Liliane Desgualdo Pereira
Background This study aimed to investigate central auditory processing performance in children with migraine and compared with controls without headache. Methods Twenty-eight children of both sexes, aged between 8 and 12 years, diagnosed with migraine with and without aura, and a control group of the same age range and with no headache history, were included. Gaps-in-noise (GIN), duration pattern test (DPT), synthetic sentence identification (SSI) test, and nonverbal dichotic test (NVDT) were used to assess central auditory processing performance...
January 25, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28120618/a-case-report-of-migraine-sine-headache
#12
Arens Taga, Marco Russo, Antonio Genovese, Gian Camillo Manzoni, Paola Torelli
Background and objectives We describe a case of a female patient whose otherwise "typical" migraine attacks turned into episodes with a full spectrum of associated symptoms but without headache. Case report We evaluated a 53-year-old woman with a long history of migraine without aura. In concomitance with premenopausal menstrual dysregulation, she reported episodes of nausea and vomiting, associated with photophobia, phonophobia and osmophobia, but without headache; these episodes were responsive to oral triptans...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28101987/delivery-outcomes-of-patients-with-acute-migraine-in-pregnancy-a-retrospective-study
#13
Tracy B Grossman, Matthew S Robbins, Shravya Govindappagari, Ashlesha K Dayal
OBJECTIVE: To describe labor and delivery outcomes in pregnant patients presenting to the hospital setting with an acute severe migraine headache attack earlier in the same gestation. METHODS: We retrospectively reviewed pregnancy and delivery records from a database of consecutive inpatient neurology consultations for acute headache in pregnant women over a 5 year period. RESULTS: We identified 86 pregnant women with acute migraine. The mean age was 29...
January 18, 2017: Headache
https://www.readbyqxmd.com/read/28079315/migraine-susceptibility-genes-in-han-chinese-of-fujian-province
#14
Qi Fang Lin, Zi Chun Chen, Xian Guo Fu, Jing Yang, Luo Yuan Cao, Long Teng Yao, Yong Tong Xin, Gen Bin Huang
BACKGROUND AND PURPOSE: Five single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population. METHODS: This was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction-restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients...
January 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28073753/migraine-and-risk-of-perioperative-ischemic-stroke-and-hospital-readmission-hospital-based-registry-study
#15
Fanny P Timm, Timothy T Houle, Stephanie D Grabitz, Anne-Louise Lihn, Janne B Stokholm, Katharina Eikermann-Haerter, Ala Nozari, Tobias Kurth, Matthias Eikermann
OBJECTIVE:  To evaluate whether patients with migraine are at increased risk of perioperative ischemic stroke and whether this may lead to an increased hospital readmission rate. DESIGN:  Prospective hospital registry study. SETTING:  Massachusetts General Hospital and two satellite campuses between January 2007 and August 2014. PARTICIPANTS:  124 558 surgical patients (mean age 52.6 years; 54.5% women). MAIN OUTCOME MEASURES:  The primary outcome was perioperative ischemic stroke occurring within 30 days after surgery in patients with and without migraine and migraine aura...
January 10, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28067735/migraine-with-aura-or-sports-related-concussion-case-report-pathophysiology-and-multidisciplinary-approach-to-management
#16
Michael J Ellis, Dean Cordingley, Richard Girardin, Lesley Ritchie, Janine Johnston
The evaluation and management of athletes presenting with clinical features of migraine headache with aura in the setting of sports-related head trauma is challenging. We present a case report of a 15-yr-old boy with a history of migraine with visual aura that developed acute visual disturbance and headache after a head injury during an ice hockey game. The patient underwent comprehensive assessment at a multidisciplinary concussion program, including neuro-ophthalmological examination, neurocognitive testing, and graded aerobic treadmill testing...
January 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28063107/the-relationship-between-right-to-left-shunt-and-brain-white-matter-lesions-in-japanese-patients-with-migraine-a-single-center-study
#17
Akio Iwasaki, Keisuke Suzuki, Hidehiro Takekawa, Ryotaro Takashima, Ayano Suzuki, Shiho Suzuki, Koichi Hirata
BACKGROUND: There may be a link between right-to-left shunt (RLs) and brain white matter lesions (WMLs) in patients with migraine. In this study, we assessed the relationship between WMLs and RLs in Japanese migraine patients. METHODS: A total of 107 consecutive patients with migraine with (MA) and without aura (MWOA) were included in this study. Contrast transcranial Doppler ultrasound was used to detect RLs. WMLs were graded using brain magnetic resonance imaging based on well-established criteria...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28063106/excitability-of-the-motor-cortex-in-patients-with-migraine-changes-with-the-time-elapsed-from-the-last-attack
#18
Francesca Cortese, Gianluca Coppola, Davide Di Lenola, Mariano Serrao, Cherubino Di Lorenzo, Vincenzo Parisi, Francesco Pierelli
BACKGROUND: Motor-evoked potentials (MEPs) produced by single-pulse transcranial magnetic stimulation (TMS) of the motor cortex can be an objective measure of cortical excitability. Previously, MEP thresholds were found to be normal, increased, or even reduced in patients with migraine. In the present study, we determined whether the level of cortical excitability changes with the time interval from the last migraine attack, thereby accounting for the inconsistencies in previous reports...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28058730/multilocus-analysis-reveals-three-candidate-genes-for-chinese-migraine-susceptibility
#19
Xing-Kai An, Jie Fang, Zhen-Zhen Yu, Qing Lin, Cong-Xia Lu, Hong-Li Qu, Qi-Lin Ma
Several genome-wide association studies (GWASs) in Caucasian populations have identified 12 loci that are significantly associated with migraine. More evidence suggests that serotonin receptors are also involved in migraine pathophysiology. In the present study, a case-control study was conducted in a cohort of 581 migraine cases and 533 ethnically matched controls among a Chinese population. Eighteen polymorphisms from serotonin receptors and GWASs were selected, and genotyping was performed using a Sequenom MALDI-TOF mass spectrometry iPLEX platform...
January 6, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28056534/episodic-status-migrainosus-a-novel-migraine-subtype
#20
Tarun D Singh, F Michael Cutrer, Jonathan H Smith
Objective To report a case series of a novel migraine subtype, which we term as episodic status migrainosus (ESM), characterized by attacks of migraine exclusively lasting more than 72 hours. We hypothesized that this would represent a novel nosologic entity, possibly an unstable migraine phenotype with a high conversion rate to chronic migraine (CM). Methods We conducted a retrospective review of patients diagnosed with status migrainosus at the Mayo Clinic, Rochester, between January 2005 and December 2015...
January 1, 2017: Cephalalgia: An International Journal of Headache
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