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Migraine with aura

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https://www.readbyqxmd.com/read/29450870/early-and-long-period-follow-up-results-of-low-glycemic-index-diet-for-migraine-prophylaxis
#1
Gökhan Evcili, Uygar Utku, Muhammed Nur Öğün, Gökhan Özdemir
OBJECTIVES: The role of dietary restriction in the management of patients with migraine is still a controversial topic in the headache field. The aim of this study was to evaluate the efficacy of dietary restriction on migraine attacks. METHODS: Patients diagnosed with migraine without aura according to the International Classification of Headaches were enrolled. Our study included 350 migraine patients evaluated at the neurology headache outpatient clinic. They were randomly divided into two groups: diet group as the study group and medication group as the control group...
January 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29427165/association-of-mthfr-gene-polymorphisms-with-migraine-in-north-indian-population
#2
Sukhvinder Kaur, Arif Ali, Anil Kumar Pandey, Balkirat Singh
Polymorphisms in MTHFR gene are mostly associated with increased levels of homocysteine in the absence of dietary folate and are a risk factor for complex neurovascular diseases like migraine. The aim of present case-control study was to determine the association between MTHFR gene polymorphisms (C667T; rs 1801133, A1298C; rs 1801131) with migraine susceptibility. In total, 100 patients with migraine (23with MA and 77 with MO) and age-sex matched 100 healthy controls were included in this study from OPD of ESIC Medical College & Hospital, Faridabad...
February 9, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29425263/determinants-of-optogenetic-cortical-spreading-depolarizations
#3
David Y Chung, Homa Sadeghian, Tao Qin, Sevda Lule, Hang Lee, Fahri Karakaya, Stacy Goins, Fumiaki Oka, Mohammad A Yaseen, Thijs Houben, Else A Tolner, Arn M J M van den Maagdenberg, Michael J Whalen, Sava Sakadžic, Cenk Ayata
Cortical spreading depolarization (SD) is the electrophysiological event underlying migraine aura, and a critical contributor to secondary damage after brain injury. Experimental models of SD have been used for decades in migraine and brain injury research; however, they are highly invasive and often cause primary tissue injury, diminishing their translational value. Here we present a non-invasive method to trigger SDs using light-induced depolarization in transgenic mice expressing channelrhodopsin-2 in neurons (Thy1-ChR2-YFP)...
February 7, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29414151/migrainous-aura-as-stroke-mimic-the-role-of-perfusion-computed-tomography
#4
Mariana Ridolfi, Antonio Granato, Paola Polverino, Giovanni Furlanis, Maja Ukmar, Irene Zorzenon, Paolo Manganotti
OBJECTIVES: The acute-onset of migrainuos aura (MA) can be erroneously diagnosed in Emergency Department (ED) as acute stroke (AS) and it can be classified as "stroke mimic" (SM). Perfusion computer tomography (PCT) may be useful to improve detection of infarcts. The aim of the study was to investigate the role in ED of PCT in improving diagnosis of migrainous aura. Data were compared with the well-defined perfusion patterns in patients with acute ischemic stroke. PATIENTS AND METHODS: A standardized Stroke Protocol was planned...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29411639/prospective-memory-is-dysfunctional-in-migraine-without-aura
#5
Gabriella Santangelo, Antonio Russo, Alessandro Tessitore, Federica Garramone, Marcello Silvestro, Maria Rosaria Della Mura, Laura Marcuccio, Ilaria Fornaro, Luigi Trojano, Gioacchino Tedeschi
Introduction Prospective memory is the ability to carry out a delayed intended action, so to maintain and retrieve future plans, goals and activities. Deficits of prospective memory negatively impact on patients and caregivers' everyday living and determine poor adherence to treatment. Since frontal regions are involved in both event- and time-based prospective memory tasks and are impaired in migraine without aura, defects of prospective memory might occur in migraine without aura patients; until now this issue has not been investigated...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29408771/headache-in-mitochondrial-disorders
#6
REVIEW
Josef Finsterer, Sinda Zarrouk-Mahjoub
Headache is a prominent feature in mitochondrial disorders (MIDs) but no comprehensive overview is currently available. This review aims at summarising and discussing findings concerning type, frequency, pathogenesis, and treatment of headache in MIDs. The most frequent headache types in MIDs are migraine and migraine-like headache (MLH). MLH is classified as secondary headache. More rarely, tension-type headache, trigemino-autonomic headache, or different secondary headaches can be found. Migraine or MLH may manifest with or without aura...
January 26, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29404159/presence-of-headache-and-migraine-in-asthma-patients
#7
Muzaffer Onur Turan, Çiğdem Çelik Susuz, Pakize Ayşe Turan
OBJECTIVES: Migraine is a diseases characterized with severe headaches, with neurological and systemic findings. The purpose of this study is to investigate the prevalence of migraine and to examine whether there is a relationship between atopic disorders, parental history and migraine in asthma patients. MATERIAL AND METHODS: A total of 288 asthma outpatients, who had the diagnosis by an early or late test of reversibility showing a reversible airway obstruction according to hospital database were included...
April 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29394508/activation-of-pial-and-dural-macrophages-and-dendritic-cells-by-csd-67-chrs
#8
Aaron J Schain, Agustin Melo-Carrillo, David Borsook, Jaime Grutzendler, Andrew M Strassman, Rami Burstein
OBJECTIVE: Cortical spreading depression (CSD) has long been implicated in migraine attacks with aura. The process by which CSD, a cortical event that occurs within the blood brain barrier (BBB), results in nociceptor activation outside the BBB is likely mediated by multiple molecules and cells. The objective of this study was to determine whether CSD activates immune cells inside the BBB (pia), outside the BBB (dura), or in both, and if so, when. METHODS: Investigating cellular events in the meninges shortly after CSD, we used in-vivo 2-photon imaging to identify changes in macrophages and dendritic cells (DC) that reside in the pia, arachnoid, and dura, and their anatomical relationship to TRPV1 axons...
February 2, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29388437/migraine-and-the-risk-of-incident-hypertension-among-women
#9
Pamela M Rist, Anke C Winter, Julie E Buring, Howard D Sesso, Tobias Kurth
Background Few studies have examined whether migraine is associated with an increased risk of incident hypertension. Methods We performed a prospective cohort study among 29,040 women without hypertension at baseline. Women were classified as having active migraine with aura, active migraine without aura, a past history of migraine, or no history of migraine. Incident hypertension was defined as new physician diagnosis or newly self-reported systolic or diastolic blood pressure ≥140 mmHg or ≥90 mmHg respectively...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29387527/high-brain-serotonin-levels-in-migraine-between-attacks-a-5-ht-4-receptor-binding-pet-study
#10
Marie Deen, Hanne D Hansen, Anders Hougaard, Martin Nørgaard, Hans Eiberg, Szabolcs Lehel, Messoud Ashina, Gitte M Knudsen
Migraine has been hypothesized to be a syndrome of chronic low serotonin (5-HT) levels, but investigations of brain 5-HT levels have given equivocal results. Here, we used positron emission tomography (PET) imaging of the 5-HT4receptor as a proxy for brain 5-HT levels. Given that the 5-HT4receptor is inversely related to brain 5-HT levels, we hypothesized that between attacks migraine patients would have higher 5-HT4receptor binding compared to controls. Eighteen migraine patients without aura (migraine free >48 h), and 16 age- and sex-matched controls underwent PET scans after injection of [11C]SB207145, a specific 5-HT4receptor radioligand...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29386181/migraine-and-risk-of-cardiovascular-diseases-danish-population-based-matched-cohort-study
#11
Kasper Adelborg, Szimonetta Komjáthiné Szépligeti, Louise Holland-Bill, Vera Ehrenstein, Erzsébet Horváth-Puhó, Victor W Henderson, Henrik Toft Sørensen
OBJECTIVE: To examine the risks of myocardial infarction, stroke (ischaemic and haemorrhagic), peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter, and heart failure in patients with migraine and in a general population comparison cohort. DESIGN: Nationwide, population based cohort study. SETTING: All Danish hospitals and hospital outpatient clinics from 1995 to 2013. PARTICIPANTS: 51 032 patients with migraine and 510 320 people from the general population matched on age, sex, and calendar year...
January 31, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29370179/location-number-and-factors-associated-with-cerebral-microbleeds-in-an-italian-british-cohort-of-cadasil-patients
#12
Serena Nannucci, Valentina Rinnoci, Giovanni Pracucci, Andrew D MacKinnon, Francesca Pescini, Poneh Adib-Samii, Silvia Bianchi, Maria Teresa Dotti, Antonio Federico, Domenico Inzitari, Hugh S Markus, Leonardo Pantoni
BACKGROUND AND PURPOSE: The frequency, clinical correlates, and risk factors of cerebral microbleeds (CMB) in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) are still poorly known. We aimed at determining the location and number of CMB and their relationship with clinical manifestations, vascular risk factors, drugs, and other neuroimaging features in CADASIL patients. METHODS: We collected clinical data by means of a structured proforma and centrally evaluated CMB on magnetic resonance gradient echo sequences applying the Microbleed Anatomical Rating Scale in CADASIL patients seen in 2 referral centers in Italy and United Kingdom...
2018: PloS One
https://www.readbyqxmd.com/read/29360944/migraine-with-visual-aura-associated-with-thicker-visual-cortex
#13
David Gaist, Anders Hougaard, Ellen Garde, Nina Linde Reislev, Rikke Wiwie, Pernille Iversen, Camilla Gøbel Madsen, Morten Blaabjerg, Helle Hvilsted Nielsen, Thomas Krøigård, Kamilla Østergaard, Kirsten Ohm Kyvik, Jacob Hjelmborg, Kristoffer Madsen, Hartwig Roman Siebner, Messoud Ashina
Until recent years it was believed that migraine with aura was a disorder causing intermittent neurological symptoms, with no impact on brain structure. However, recent MRI studies have reported increased cortical thickness of visual and somatosensory areas in patients with migraine with aura, suggesting that such structural alterations were either due to increased neuronal density in the areas involved, or a result of multiple episodes of cortical spreading depression as part of aura attacks. Subsequent studies have yielded conflicting results, possibly due to methodological reasons, e...
January 18, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29357368/serum-apolipoprotein-e-may-be-a-novel-biomarker-of-migraine
#14
Naoki Yuasa, Eiichiro Nagata, Natsuko Fujii, Masatoshi Ito, Hideo Tsukamoto, Shunya Takizawa
Migraine attacks alter various molecules that might be related to the pathophysiology of migraine, such as serotonin, calcitonin gene-related peptide, and nitric oxide. The underlying pathophysiology of migraine is as yet unclear. We explored key proteins related to the pathogenesis of migraine here. Serum was collected from two patients with migraine with aura (MA) and seven patients with migraine without aura (MO) during attack-free periods and migraine attacks. Samples were analyzed using 2-dimensional gel electrophoresis...
2018: PloS One
https://www.readbyqxmd.com/read/29350588/arguments-against-the-role-of-cortical-spreading-depression-in-migraine
#15
Piet Borgdorff
Cortical spreading depression (CSD) is a wave of increased electrocortical activity and vasodilation, followed by sustained decreased activity and prolonged vasoconstriction. Although the discovery of CSD has been ascribed to Leão, rather than vasoconstriction, he only observed a depression of neural activity combined with vasodilation, with much weaker stimulation than used by his followers. There is a longstanding belief that CSD underlies migraine aura, with its positive symptoms such as mosaic patterns and its negative symptoms such as scotoma, and a similar propagation speed and vasoreaction pattern...
January 19, 2018: Neurological Research
https://www.readbyqxmd.com/read/29336986/a-systematic-literature-review-of-observational-studies-of-the-bidirectional-association-between-metabolic-syndrome-and-migraine
#16
REVIEW
V A Andreeva, P Galan, C Julia, L Fezeu, S Hercberg, E Kesse-Guyot
AIMS: To evaluate all epidemiological evidence in the literature linking the metabolic syndrome (MetS) and migraine in adults. METHODS: Database (Medline, Embase; published reports up to November 2017) and manual searches were performed. Information on data collection, sample characteristics, study design, MetS and migraine assessment, and results was extracted from each relevant publication. The methodological quality of each study was also assessed. RESULTS: A total of 15 observational epidemiological studies in adults, published between 2009 and 2017, were retrieved...
December 13, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29331612/arterial-spin-labeling-cerebral-perfusion-magnetic-resonance-imaging-in-migraine-aura-an-observational-study
#17
Marc E Wolf, Shuhei Okazaki, Philipp Eisele, Christina Rossmanith, Johannes Gregori, Martin Griebe, Matthias Günther, Achim Gass, Michael G Hennerici, Kristina Szabo, Rolf Kern
BACKGROUND: Changes in cerebral perfusion during migraine with aura (MA) have been assessed mainly using dynamic susceptibility contrast (DSC) magnetic resonance perfusion imaging. A contrast agent-free method to assess these changes would be desirable. We assessed changes in cerebral perfusion during MA using arterial spin labeling (ASL) perfusion magnetic resonance imaging. METHODS: We investigated 4 patients with a standardized protocol including ASL perfusion imaging during MA (n = 2) or early headache phase (n = 2) and asymptomatic follow-up...
January 10, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29327224/prevalence-and-clinical-characteristics-of-headache-in-juvenile-myoclonic-epilepsy-experience-from-a-tertiary-epilepsy-center
#18
Metin Dedei Daryan, Betül Tekin Güveli, Sezin Alpaydın Baslo, Kasım Mulhan, Hüseyin Sarı, Zeynep Ezgi Balçık, Dilek Ataklı
The comorbidity of headache and epilepsy is often seen in neurological practice. The objective of this study was to assess the prevalence, types of, and risk factors for headache in juvenile myoclonic epilepsy (JME). We assessed a total of 200 patients and 100 healthy controls in our study. Headache was classified in participants using a self-administered questionnaire. Demographical, clinical features and headache characteristics were recorded. Seizure and headache temporal profiles were noted. Headache was present in 111 (56%) patients and 50 (50%) healthy participants...
January 11, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29326138/cerebellar-hypoperfusion-in-migraine-attack-incidence-and-significance
#19
F Kellner-Weldon, M El-Koussy, S Jung, M Jossen, P P Klinger-Gratz, R Wiest
BACKGROUND AND PURPOSE: Patients diagnosed with migraine with aura have an increased lifetime risk of ischemic stroke. It is not yet clear whether prolonged cortical hypoperfusion during an aura increases the immediate risk of cerebellar infarction because it may induce crossed cerebellar diaschisis and subsequent tissue damage. To address this question, we retrospectively analyzed potential relationships between cortical oligemia and cerebellar hypoperfusion in patients with migraine with aura and their potential relation to small infarct-like cerebellar lesions...
January 11, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29302188/migraine-in-young-females-with-irritable-bowel-syndrome-still-a-challenge
#20
Doina Georgescu, Daniela Reisz, Camelia Vidita Gurban, Liviu Andrei Georgescu, Ioana Ionita, Oana Elena Ancusa, Daniel Lighezan
Migraine without aura is frequently reported in female patients with irritable bowel syndrome (IBS), but knowledge about the relationship between these two conditions is still lacking. This study was aimed to explore the particularities of migraine without aura in young female patients with IBS in order to establish a possible link between them. From a cohort of young female patients hospitalized with IBS in the Internal Medicine Department, 30 joined this pilot study, and they were assigned into two groups on the basis of presence or absence of migraine...
2018: Neuropsychiatric Disease and Treatment
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