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Migraine with aura

Roberto Teggi, Bruno Colombo, Roberto Albera, Giacinto Asprella Libonati, Cristiano Balzanelli, Angel Batuecas Caletrio, Augusto P Casani, Juan Manuel Espinosa-Sanchez, Paolo Gamba, Jose A Lopez-Escamez, Sergio Lucisano, Marco Mandalà, Giampiero Neri, Daniele Nuti, Rudi Pecci, Antonio Russo, Eduardo Martin-Sanz, Ricardo Sanz, Gioacchino Tedeschi, Paola Torelli, Paolo Vannucchi, Giancarlo Comi, Mario Bussi
Migraine is a common neurological disorder characterized by episodic headaches with specific features, presenting familial aggregation. Migraine is associated with episodic vertigo, named Vestibular Migraine (VM) whose diagnosis mainly rely on clinical history showing a temporary association of symptoms. Some patient refers symptoms occurring in pediatric age, defined "episodic symptoms which may be associated with migraine." The aim of this cross sectional observational study was to assess migraine-related clinical features in VM subjects...
2018: Frontiers in Neurology
Marta Kowalska, Magdalena Kapelusiak-Pielok, Teresa Grzelak, Ewa Wypasek, Wojciech Kozubski, Jolanta Dorszewska
Migraine is one of the most common primary headache disorders that affects 11% of the adult population. The disease is divided into two main clinical subtypes: migraine with aura (MA) and migraine without aura (MO). Both serotonergic and hypocretinergic systems are involved in the migraine pathomechanism. Polymorphisms in the serotonin transporter gene ( SLC6A4 ) and the hypocretin receptor 1 gene ( HCRTR1 ) may be risk factors for migraine development due to their ability to affect serotonin and hypocretin-1 (HCRT-1) concentrations...
2018: Frontiers in Molecular Neuroscience
Ayman Elbadawi, Kirolos Barssoum, Ahmed S Abuzaid, Ahmed Rezq, Nishit Biniwale, Erfan Alotaki, Ahmed H Mohamed, Sowjanya Vuyyala, Gbolahan O Ogunbayo, Marwan Saad
BACKGROUND: The role of percutaneous patent foramen ovale (PFO) closure for prevention of migraine is controversial. METHODS: We performed a computerised search of MEDLINE, EMBASE and COCHRANE databases through December 2017 for randomised trials evaluating PFO closure versus control in patients with migraine headaches (with or without aura). The main study outcome was the reduction in monthly migraine attacks after PFO closure compared with the control group. RESULTS: The final analysis included three randomised trials with a total of 484 patients...
June 18, 2018: Acta Cardiologica
Anders Hougaard, Anne Werner Hauge, Song Guo, Peer Tfelt-Hansen
Background and aims NXN-188 is a combined neuronal nitric oxide synthase (nNOS) inhibitor and 5HT-1B/1D receptor agonist which has previously shown efficacy in the acute treatment of migraine. Nitric oxide (NO) is involved in the pathogenesis of migraine pain and is formed after cortical spreading depression. Therefore NXN-188 could perhaps prevent the development of the headache phase in migraine with aura if taken during the aura. The aims of the present study were to evaluate the efficacy and safety of 600mg NXN-188 in the acute treatment of migraine when dosed during the aura...
December 29, 2017: Scandinavian Journal of Pain
Nadine Pelzer, Mark A Louter, Erik W van Zwet, Dale R Nyholt, Michel D Ferrari, Arn Mjm van den Maagdenberg, Joost Haan, Gisela M Terwindt
Background Migraine is a complex genetic disorder that is brought about by multiple genetic and environmental factors. We aimed to assess whether migraine frequency is associated with genetic susceptibility. Methods We investigated in 2829 migraine patients (14% males) whether 'migraine frequency' (measured as the number of migraine days per month) was related to 'genetic load' (measured as the number of parents affected with migraine) using a validated web-based questionnaire. In addition, we investigated associations with age-at-onset, migraine subtype, use of acute headache medication, and comorbid depression...
January 1, 2018: Cephalalgia: An International Journal of Headache
Cristina Tassorelli, Licia Grazzi, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Stefanie Dorlas, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti
OBJECTIVE: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled trial. METHODS: A total of 248 participants with episodic migraine with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants were to repeat treatment if pain had not improved in 15 minutes...
June 15, 2018: Neurology
Cinzia Fatini, Michela Cirillo, Maria Elisabetta Coccia
BACKGROUND: A growing number of infertile women undergo assisted reproductive technology (ART). Older maternal age and the presence of comorbidities may affect cardiovascular (CV) women health. Safety aspects are central in risk assessment; we report the experience of internal medicine clinical setting at the ART center. MATERIALS AND METHODS: we investigated 243 infertile women (110 autologous and 133 oocyte donation [OD]); cardiometabolic parameters and CV risk factors were investigated during the clinical evaluation...
June 15, 2018: Journal of Women's Health
Gianluca Cecchi, Matteo Paolucci, Martina Ulivi, Federica Assenza, Nicoletta Brunelli, Angelo Cascio Rizzo, Claudia Altamura, Fabrizio Vernieri
No abstract text is available yet for this article.
June 2018: Neurological Sciences
Simone Quintana, Antonio Genovese, Francesco Rausa, Gian Camillo Manzoni, Paola Torelli
No abstract text is available yet for this article.
June 2018: Neurological Sciences
Katia Khouri Chalouhi, Silvia Squarza, Anna Pisani Mainini, Paola Di Fiore, Maurizio Cariati, Fabio Frediani, Carla Uggetti
No abstract text is available yet for this article.
June 2018: Neurological Sciences
Antonio Russo, Marcello Silvestro, Alessandro Tessitore, Gioacchino Tedeschi
No abstract text is available yet for this article.
June 2018: Neurological Sciences
Alberto Galli, Paola Di Fiore, Giacomo D'Arrigo, Carla Uggetti, Silvia Squarza, Massimo Leone, Domenico D'Amico, Fabio Frediani
No abstract text is available yet for this article.
June 2018: Neurological Sciences
Claudia Altamura, Matteo Paolucci, Nicoletta Brunelli, Angelo Cascio Rizzo, Fabrizio Vernieri
No abstract text is available yet for this article.
June 2018: Neurological Sciences
Elio Clemente Agostoni, Marco Longoni
Migraine is a common type of headache in young adults, with an estimated prevalence of 4% before puberty and as high as 25% in women by their mid to late 30s. About one third of migraineurs experience transient neurological symptoms known as auras, which characterize a variant known as migraine with aura. Many evidences have shown an increased risk of vascular events in patients affected by migraine, particularly among women and among migraine patients with aura. Potential underlying mechanisms include endothelial dysfunction, hypercoagulability, platelet aggregation, vasospasm, cardiovascular risk factors, paradoxical embolism, spreading depolarization, shared genetic risk, use of non-steroidal anti-inflammatory drugs, and immobilization...
June 2018: Neurological Sciences
Gianni Allais, Giulia Chiarle, Silvia Sinigaglia, Gisella Airola, Paola Schiapparelli, Chiara Benedetto
Migraine has a predilection for female sex and the course of symptoms is influenced by life stage (presence of menstrual cycle, pregnancy, puerperium, menopause) and use of hormone therapy, such as hormonal contraception and hormone replacement therapy. Hormonal changes figure among common migraine triggers, especially sudden estrogen drop. Moreover, estrogens can modulate neuronal excitability, through serotonin, norepinephrine, dopamine, and endorphin regulation, and they interact with the vascular endothelium of the brain...
June 2018: Neurological Sciences
K M Cobb-Pitstick, N Munjal, R Safier, D D Cummings, G Zuccoli
Hemiplegic migraine is a common cause of acute brain attack in pediatrics. MR imaging sequences useful in differentiating hemiplegic migraine from other entities include arterial spin-labeling, SWI, MRA, and DWI. There has been limited exploration on the simultaneous use of these sequences in pediatrics. We present 12 pediatric patients with acute hemiplegic migraine or migraine with aura who underwent MR imaging within 12 hours of symptom onset. Quantitative and qualitative analyses were performed on arterial spin-labeling; and qualitative analysis, on SWI and MRA sequences...
June 14, 2018: AJNR. American Journal of Neuroradiology
Håkan Ashina, Henrik Winther Schytz, Messoud Ashina
Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key molecule. Provocation experiments have demonstrated that intravenous CGRP infusion induces migraine-like attacks in migraine with and without aura patients. In addition, these studies have revealed a heterogeneous CGRP response, i.e., some migraine patients develop migraine-like attacks after CGRP infusion, while others do not. The role of CGRP in human migraine models has pointed to three potential sites of CGRP-induced migraine: (1) vasodilation via cyclic adenosine monophosphate (cAMP) and possibly cyclic guanosine monophosphate (cGMP); (2) activation of trigeminal sensory afferents, and (3) modulation of deep brain structures...
June 13, 2018: Handbook of Experimental Pharmacology
Richard B Lipton, Sagar Munjal, Elimor Brand-Schieber, Alan M Rapoport
OBJECTIVE: The objective of this study was to evaluate the efficacy, safety, and tolerability of DFN-02 - a nasal spray comprising sumatriptan 10 mg and a permeation-enhancing excipient (0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside [DDM]) - for the acute treatment of migraine with or without aura in adults. BACKGROUND: Prior work has shown that DFN-02, which contains only half the recommended adult dose of sumatriptan found in the original formulation (10 mg vs 20 mg), is more rapidly absorbed than commercial nasal spray of sumatriptan, with favorable pharmacokinetic and safety profiles...
May 2018: Headache
Laura L Hanson, Zubair Ahmed, Bradley J Katz, Judith E A Warner, Alison V Crum, Yingying Zhang, Yue Zhang, Susan Baggaley, Karly Pippett, Melissa M Cortez, Kathleen B Digre
OBJECTIVE: Migraine is associated with several important visual symptoms, during both acute attacks and headache-free intervals. The purpose of this investigation was to use validated vision-related quality of life instruments to assess the effect of migraine on visual quality of life. BACKGROUND: Many migraineurs experience visual aura, increased photophobia during and between headache attacks, and increased symptoms of dry eye with structural changes in corneal nerve endings...
June 7, 2018: Headache
Janos Tajti, Melinda Látos, Szabolcs Ábrahám, Zsolt Simonka, Attila Paszt, György Lázár
Background and purpose: Tension-type headache is a very common disease with a high socio-economic impact as its lifetime prevalence is 30-78% in the general population. The incidence of inflammatory bowel diseases is continuously rising. Limited data are accessible on quality of life in patients with surgically treated ulcerative colitis. The aim of our study is to examine quality of life, concerning headache, among patients who had undergone surgery due to ulcerative colitis. Methods: Between 1 January 2005 and 1 March 2016, surgery was performed due to ulcerative colitis in 75 patients...
November 30, 2017: Ideggyógyászati Szemle
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