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Cancer EUG

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https://www.readbyqxmd.com/read/27235711/apoptotic-effect-of-eugenol-envolves-g2-m-phase-abrogation-accompanied-by-mitochondrial-damage-and-clastogenic-effect-on-cancer-cell-in-vitro
#1
Paulo Luiz de Sá Júnior, Diana Aparecida Dias Câmara, André Santos Costa, Jorge Luis Maria Ruiz, Débora Levy, Ricardo Alexandre Azevedo, Kerly Fernanda Mesquita Pasqualoto, Camila Fávero de Oliveira, Thatiana Corrêa de Melo, Nara Diniz Soares Pessoa, Pâmela Maria Moreira Fonseca, Alexandre Pereira, Rodrigo Pinheiro Araldi, Adilson Kleber Ferreira
BACKGROUND: Eugenol (EUG) is a major phenolic compound present in clove whose anti-cancer properties have been demonstrated previously. These anti-cancer properties may involves the modulation of different mechanisms, including α-estrogen receptor (αER) in luminal breast cancer cells, COX-2 inhibition in melanoma cells or p53 and caspase-3 activation in colon cancer cells. HYPOTHESIS: EUG promotes a burst in ROS production causing cell-cycle perturbations, mitochondria toxicity and clastogenesis triggering apoptosis in melanoma breast- and cervix-cancer cells in vitro...
June 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/25879466/the-implementation-of-an-organised-cervical-screening-programme-in-poland-an-analysis-of-the-adherence-to-european-guidelines
#2
Andrzej Nowakowski, Marek Cybulski, Andrzej Śliwczyński, Arkadiusz Chil, Zbigniew Teter, Przemysław Seroczyński, Marc Arbyn, Ahti Anttila
BACKGROUND: Well-organised quality-controlled screening can substantially reduce the burden of cervical cancer (CC). European guidelines (EuG) for quality assurance in CC screening provide guidance on all aspects of an organised screening programme. Organised CC screening in Poland was introduced in 2007. The purpose of our study was to analyse: (i) adherence of the programme to EuG; (ii) programme process and performance indicators; (iii) impact of the programme on the incidence of and mortality from CC...
2015: BMC Cancer
https://www.readbyqxmd.com/read/25661823/synergy-among-thymol-eugenol-berberine-cinnamaldehyde-and-streptomycin-against-planktonic-and-biofilm-associated-food-borne-pathogens
#3
Q Liu, H Niu, W Zhang, H Mu, C Sun, J Duan
UNLABELLED: Essential oils have been found to exert antibacterial, antifungal, spasmolytic, and antiplasmodial activity and therapeutic effect in cancer treatment. In this study, the antibacterial activities of four main essential oils' components (thymol (Thy), eugenol (Eug), berberine (Ber), and cinnamaldehyde (Cin)) were evaluated against two food-borne pathogens, Listeria monocytogenes and Salmonella Typhimurium, either alone or in combination with streptomycin. Checkerboard assay demonstrated that Thy and Cin elicited a synergistic effect with streptomycin against L...
May 2015: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/25226618/the-novel-aryl-hydrocarbon-receptor-inhibitor-biseugenol-inhibits-gastric-tumor-growth-and-peritoneal-dissemination
#4
De-Wei Lai, Shing-Hwa Liu, Anna Isabella Karlsson, Wen-Jane Lee, Keh-Bin Wang, Yi-Ching Chen, Chin-Chang Shen, Sheng-Mao Wu, Chia-Yu Liu, Hsing-Ru Tien, Yen-Chun Peng, Yee-Jee Jan, Te-Hsin Chao, Keng-Hsin Lan, Jack L Arbiser, Meei-Ling Sheu
Biseugenol (Eug) is known to antiproliferative of cancer cells; however, to date, the antiperitoneal dissemination effects have not been studied in any mouse cancer model. In this study, Aryl hydrocarbon receptor (AhR) expression was associated with lymph node and distant metastasis in patients with gastric cancer and was correlated with clinicolpathological pattern. We evaluated the antiperitoneal dissemination potential of knockdown AhR and Biseugenol in cancer mouse model and assessed mesenchymal characteristics...
September 15, 2014: Oncotarget
https://www.readbyqxmd.com/read/16433026/anti-and-pro-oxidant-effects-of-oxidized-quercetin-curcumin-or-curcumin-related-compounds-with-thiols-or-ascorbate-as-measured-by-the-induction-period-method
#5
Seiichiro Fujisawa, Yoshinori Kadoma
Phenolic antioxidants, such as quercetin (QUE), curcumin (CUR) and the CUR-related compounds eugenol (EUG) and isoeugenol (IsoEUG), do not act in isolation in vivo but form an intricate antioxidant network together with ascorbate or glutathione (GSH). To clarify the antioxidant/prooxidant activity of these compounds in their interplay with ascorbate or GSH, the induction period (IP) and propagation rate (Rp) for mixtures of 2-mercapto-1-methylimidazole (MMI, a thiol) or L-ascorbyl-2,6-dibutyrate (ASDB, an ascorbate derivative) with QUE, CUR, EUG or IsoEUG were determined from differential scanning calorimetry (DSC) monitoring of the polymerization of methyl methacrylate (MMA), initiated by thermal decomposition of 1...
January 2006: In Vivo
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