De-Wei Lai, Shing-Hwa Liu, Anna Isabella Karlsson, Wen-Jane Lee, Keh-Bin Wang, Yi-Ching Chen, Chin-Chang Shen, Sheng-Mao Wu, Chia-Yu Liu, Hsing-Ru Tien, Yen-Chun Peng, Yee-Jee Jan, Te-Hsin Chao, Keng-Hsin Lan, Jack L Arbiser, Meei-Ling Sheu
Biseugenol (Eug) is known to antiproliferative of cancer cells; however, to date, the antiperitoneal dissemination effects have not been studied in any mouse cancer model. In this study, Aryl hydrocarbon receptor (AhR) expression was associated with lymph node and distant metastasis in patients with gastric cancer and was correlated with clinicolpathological pattern. We evaluated the antiperitoneal dissemination potential of knockdown AhR and Biseugenol in cancer mouse model and assessed mesenchymal characteristics...
September 15, 2014: Oncotarget