Peng Zhou, Yu Xiao, Xin Zhou, Jinghui Fang, Jingwen Zhang, Jianjun Liu, Ling Guo, Jiuhong Zhang, Ning Zhang, Ke Chen, Chao Zhao
Spatiotemporal heterogeneity of tumors provides an escape mechanism for breast cancer cells, which can obstruct the investigation of tumor progression. While molecular profiling obtained from mass spectrometry imaging (MSI) is rich in biochemical information, it lacks the capacity for in vivo analysis. Ultrasound diagnosis has a high diagnostic accuracy but low chemical specificity. Here, we describe a noninvasive ultrasound elastography (UE)-guided MSI strategy (UEg-MSI) that integrates physical and biochemical characteristics of tumors acquired from both in vivo and in vitro imaging...
February 26, 2024: JACS Au