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https://www.readbyqxmd.com/read/29786110/multi%C3%A2-layered-prevention-and-treatment-of-chronic-inflammation-organ-fibrosis-and-cancer-associated-with-canonical-wnt-%C3%AE-%C3%A2-catenin-signaling-activation-review
#1
Masaru Katoh
β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulators (BCL9, BCL9L, CREBBP/CBP, EP300/p300, FOXM1, MED12, SMARCA4/BRG1 and TCF/LEF). Gain‑of‑function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss‑of‑function CTNNB1 mutations are also detected in human cancer...
May 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29784765/dawdle-interacts-with-dicer-like-proteins-to-mediate-small-rna-biogenesis
#2
Shuxin Zhang, Yongchao Dou, Shengjun Li, Guodong Ren, David Chevalier, Chi Zhang, Bin Yu
DAWDLE (DDL) is a conserved forkhead-associated (FHA) domain-containing protein with essential roles in plant development and immunity. It acts in the biogenesis of microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs), which regulate gene expression at the transcriptional and/or post-transcriptional levels. However, the functional mechanism of DDL and its impact on exogenous siRNAs remain elusive. Here we report that DDL is required for the biogenesis of siRNAs derived from sense transgenes and inverted-repeat transgenes...
May 21, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29775245/subunits-of-the-dna-polymerase-alpha-primase-complex-promote-notch-mediated-proliferation-with-discrete-and-shared-functions-in-c-elegans-germline
#3
Dong Suk Yoon, Dong Seok Cha, Mohammad A Alfhili, Brett D Keiper, Myon-Hee Lee
Notch receptor signaling is a highly conserved cell communication system in most multicellular organisms and plays a critical role at several junctures in animal development. In C. elegans, GLP-1/Notch signaling is essential for both germline stem cell maintenance and germ cell proliferation during gonad development. Here, we show that subunits (POLA-1, DIV-1, PRI-1, and PRI-2) of the DNA polymerase alpha-primase complex are required for germ cell proliferation in response to GLP-1/Notch signaling in different tissues at different developmental stages...
May 18, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29772671/quantification-of-methane-and-ammonia-emissions-in-a-naturally-ventilated-barn-by-using-defined-criteria-to-calculate-emission-rates
#4
Alexander J Schmithausen, Inga Schiefler, Manfred Trimborn, Katrin Gerlach, Karl-Heinz Südekum, Martin Pries, Wolfgang Büscher
Extensive experimentation on individual animals in respiration chambers has already been carried out to evaluate the potential of dietary changes and opportunities to mitigate CH₄ emissions from ruminants. Although it is difficult to determine the air exchange rate of open barn spaces, measurements at the herd level should provide similarly reliable and robust results. The primary objective of this study was (1) to define a validity range (data classification criteria (DCC)) for the variables of wind velocity and wind direction during long-term measurements at barn level; and (2) to apply this validity range to a feeding trial in a naturally cross-flow ventilated dairy barn...
May 16, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29770797/correlation-of-the-predisposition-of-chinese-children-to-cerebral-palsy-with-nucleotide-variation-in-pri-mir-124-that-alters-the-non-canonical-apoptosis-pathway
#5
Hui Li, Xiu-Li Wang, Yan-Qiu Wu, Xiu-Mei Liu, Ai-Min Li
Cerebral palsy is a group of non-progressive motor impairment syndromes caused by brain lesions during development. Herein, we investigated the relationship between nucleotide variations in a miRNA coding region and the predisposition of Chinese children to cerebral palsy. A total of 233 CP patients and 256 healthy participants were enrolled, and 60 children were selected from each group for plasma miRNA detection. We screened the coding regions of pri-miR-124-1, -2, and -3 using PCR and sequencing. The expression of miR-124 was determined by qRT-PCR...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29769717/swi2-snf2-atpase-chr2-remodels-pri-mirnas-via-serrate-to-impede-mirna-production
#6
Zhiye Wang, Zeyang Ma, Claudia Castillo-González, Di Sun, Yanjun Li, Bin Yu, Baoyu Zhao, Pingwei Li, Xiuren Zhang
Chromatin remodelling factors (CHRs) typically function to alter chromatin structure. CHRs also reside in ribonucleoprotein complexes, but little is known about their RNA-related functions. Here we show that CHR2 (also known as BRM), the ATPase subunit of the large switch/sucrose non-fermentable (SWI/SNF) complex, is a partner of the Microprocessor component Serrate (SE). CHR2 promotes the transcription of primary microRNA precursors (pri-miRNAs) while repressing miRNA accumulation in vivo. Direct interaction with SE is required for post-transcriptional inhibition of miRNA accumulation by CHR2 but not for its transcriptional activity...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29761958/-magnitude-image-guided-phase-unwrapping-algorithm-of-susceptibility-weighted-images
#7
Xinling Li, Yunzhi Huang, Luyi Han, Qi Liu, Ling He, Jin Zhang, Junpeng Zhang, Jiang Zhang
To better use the phase information to compensate the influence of blood flow, the phase unwrapping problem in susceptibility weighted imaging (SWI) is studied in this paper. In order to improve the accuracy of unwrapping, this paper proposes a magnitude image-guided phase unwrapping algorithm of SWI. The basic idea is as follows: (1) reduce the influence of noise by improving the rotational invariant non-local principal component analysis method (PRI-NL-PCA); (2) extract the corresponding solid region in the phase image to avoid the influence of the background noise on the phase unwrapping method; (3) use the phase compensation method to constrain the phase image reconstructed by the K-space...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29754238/construction-and-integration-of-a-synthetic-microrna-cluster-for-multiplex-rna-interference-in-mammalian-cells
#8
Tingting Wang, Zhen Xie
Basic biological research and biomedical applications often require studying the multiple interactions between genes or proteins while multiplex RNA interference (RNAi) technology is still challenging in mammalian cells. In mammalian genomes, the natural microRNA (miRNA) clusters, of which the miRNAs often share similar expression patterns and target diverse genes, would provide a potential multiplex RNAi scaffold. Based on the natural pri-miR-155 precursor, we have developed and characterized a multiplex RNAi method by engineering synthetic miRNA clusters, among which the maturation and function of individual miRNA precursors are independent of their positions in the cluster...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29750583/the-association-of-pri-mirna-26a1-rs7372209-polymorphism-and-preeclampsia-susceptibility
#9
Fatemeh Eskandari, Mahnaz Rezaei, Abbas Mohammadpour-Gharehbagh, Batool Teimoori, Minoo Yaghmaei, Mehrnaz Narooei-Nejad, Saeedeh Salimi
MicroRNAs (miRNAs) are a class of noncoding small RNAs which regulate gene expression through post-transcriptional repression or degradation of messenger RNA. They play very important roles in various biological processes including growth, differentiation, and proliferation, as well as apoptosis, angiogenesis, and metabolism. Therefore, in the present study, we evaluated the possible effect of functional rs7372209C/T polymorphism in the 5'- region of pri-miRNA- 26a1gene on preeclampsia(PE) susceptibility. This case-control study was conducted on 219 PE women and 204 unrelated healthy controls...
May 11, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29750274/microprocessor-depends-on-hemin-to-recognize-the-apical-loop-of-primary-microrna
#10
Tuan Anh Nguyen, Joha Park, Thi Lieu Dang, Yeon-Gil Choi, V Narry Kim
Microprocessor, which consists of a ribonuclease III DROSHA and its cofactor DGCR8, initiates microRNA (miRNA) maturation by cleaving primary miRNA transcripts (pri-miRNAs). We recently demonstrated that the DGCR8 dimer recognizes the apical elements of pri-miRNAs, including the UGU motif, to accurately locate and orient Microprocessor on pri-miRNAs. However, the mechanism underlying the selective RNA binding remains unknown. In this study, we find that hemin, a ferric ion-containing porphyrin, enhances the specific interaction between the apical UGU motif and the DGCR8 dimer, allowing Microprocessor to achieve high efficiency and fidelity of pri-miRNA processing in vitro...
May 10, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29748750/clinical-and-laboratory-features-of-children-with-community-acquired-pneumonia-are-associated-with-distinct-radiographic-presentations
#11
Oana G Falup-Pecurariu, Javier Diez-Domingo, Susanna Esposito, Adam Finn, Fernanda Rodrigues, Vana Spoulou, George A Syrogiannopoulos, Vytautas Usonis, David Greenberg
Chest radiographs from children with community-acquired pneumonia (CAP) were categorized into three distinct presentations and each presentation was correlated to clinical and laboratory findings. Children < 59 months with CAP presenting to pediatric emergency rooms during two years were enrolled prospectively in eight centers across Europe. Clinical and laboratory data were documented and radiographs obtained from patients. Of the 1107 enrolled patients, radiographs were characterized as 74.9% alveolar CAP, 8...
May 11, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29747053/use-of-acellular-collagen-matrix-for-the-closure-of-the-open-oral-wound-in-bone-regeneration
#12
Dragan Stankovic, Milica Labudovic-Borovic, Radoslav Radosavljevic, Milos Marinkovic, Esma R Isenovic
Mucograft is collagen matrix was designed for use in open healing situations due to its compact outer layer. The technique presented in this article is an attempt to avail this attribute for covering open oral wound in guided bone regeneration (GBR) procedure. The essential idea of this technique is to avoid scoring of periosteum, submucosa and muscle layer for buccal flap advancement. Therefore, we used mucograft to cover bone substitute and barrier membrane in GBR surgical procedure. Thus, we avoided periostal-releasing incisions (PRI) and gained reposition of the flap to original level without impairing the attached keratinized gingiva...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29746670/dicer-cleaves-5-extended-microrna-precursors-originating-from-rna-polymerase-ii-transcription-start-sites
#13
Peike Sheng, Christopher Fields, Kelsey Aadland, Tianqi Wei, Oralia Kolaczkowski, Tongjun Gu, Bryan Kolaczkowski, Mingyi Xie
MicroRNAs (miRNAs) are approximately 22 nucleotide (nt) long and play important roles in post-transcriptional regulation in both plants and animals. In animals, precursor (pre-) miRNAs are ∼70 nt hairpins produced by Drosha cleavage of long primary (pri-) miRNAs in the nucleus. Exportin-5 (XPO5) transports pre-miRNAs into the cytoplasm for Dicer processing. Alternatively, pre-miRNAs containing a 5' 7-methylguanine (m7G-) cap can be generated independently of Drosha and XPO5. Here we identify a class of m7G-capped pre-miRNAs with 5' extensions up to 39 nt long...
May 9, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29734654/the-novel-mirna-n-72-regulates-egf-induced-migration-of-human-amnion-mesenchymal-stem-cells-by-targeting-mmp2
#14
Ying Li, Dianbao Zhang, Meng Chen, Rui Wang, Tao Zhang, Feng Zhao, Xuewen Lin, Xining Pang
Human amnion mesenchymal stem cells (hAMSCs) are promising sources of stem cells in regenerative medicine. The migration stimulated by cytokines is critical for mesenchymal stem cells (MSCs)-based cytotherapy, while the regulatory mechanisms of EGF (epidermal growth factor)-induced hAMSC migration are largely unclear. Here, a novel miRNA N-72 (GenBank accession number: MH269369) has been discovered, and its function on EGF-induced migration in hAMSCs was investigated. High-purity hAMSCs were isolated and cultured in vitro, which were characterized by flow cytometry and trilineage differentiation...
May 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29731758/interspecies-interactions-in-relation-to-root-distribution-across-the-rooting-profile-in-wheat-maize-intercropping-under-different-plant-densities
#15
Yifan Wang, Yazhou Qin, Qiang Chai, Fuxue Feng, Cai Zhao, Aizhong Yu
In wheat-maize intercropping systems, the maize is often disadvantageous over the wheat during the co-growth period. It is unknown whether the impaired growth of maize can be recovered through the enhancement of the belowground interspecies interactions. In this study, we (i) determined the mechanism of the belowground interaction in relation to root growth and distribution under different maize plant densities, and (ii) quantified the "recovery effect" of maize after wheat harvest. The three-year (2014-2016) field experiment was conducted at the Oasis Agriculture Research Station of Gansu Agricultural University, Wuwei, Northwest China...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29729094/pulse-wave-velocity-in-the-microcirculation-reflects-both-vascular-compliance-and-resistance-insights-from-computational-approaches
#16
Qing Pan, Ruofan Wang, Bettina Reglin, Luping Fang, Jing Yan, Guolong Cai, Wolfgang M Kuebler, Axel R Pries, Gangmin Ning
OBJECTIVE: Pulse wave velocity (PWV) is the speed of pulse wave propagation through the circulatory system. Microvascular PWV (mPWV) emerges as a novel indicator of hypertension, yet it remains unclear how different vascular properties affect mPWV. We aim to identify the biomechanical determinants of mPWV. METHODS: A one-dimensional (1D) model was used to simulate PWV in a rat mesenteric microvascular network and, for comparison, in a human macrovascular arterial network...
May 5, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29727133/identifying-vulnerable-periods-of-neurotoxicity-to-triclosan-exposure-in-children
#17
Medina S Jackson-Browne, George D Papandonatos, Aimin Chen, Antonia M Calafat, Kimberly Yolton, Bruce P Lanphear, Joseph M Braun
BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. METHODS: We quantified triclosan in urine samples from mother-child pairs up to nine times between the second trimester of gestation and 8 y of age...
May 2, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29719715/striking-transformations-of-the-hydroborylene-ligand-in-a-hb-%C3%A2-ni-ii-complex-with-isocyanides-and-co
#18
T J Hadlington, T Szilvási, M Driess
For the first time, the reactivity of the metal- and N-heterocyclic carbene-supported monovalent hydroborylene is reported. Isocyanides react with the hydroborylene NiII complex [{cat(TMS L)Si}(Cl)Ni←:BH(NHC)2 ] 1 (cat = ortho -C6 H4 O2 ; TMS L = N(SiMe3 )(Dipp); Dipp = 2,6-Pri 2 C6 H3 ; NHC = :C[(Pri )NC(Me)]2 ) to form the hydride-bridged hydroborylene-NiII complexes 2 . The reaction of 1 with isoelectronic CO, however, is reversible and furnishes the related unprecedented hydride- and CO-bridged hydroborylene NiII complex 2-CO , which undergoes isomerisation through silyl/NHC exchange at ambient temperature to afford the corresponding hydro(silyl)boryl NiII complex 3 ...
March 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29718070/accelerated-cognitive-ageing-in-epilepsy-a-neuropsychological-evaluation-of-cognitive-deterioration
#19
Lisanne E M Breuer, Antoine Bernas, Paul Boon, René M H Besseling, Evelien C B Carrette, Anton de Louw, Albert P Aldenkamp
Objective: Shed light on cognitive deterioration in Accelerated Cognitive Ageing (ACA) in epilepsy from a neuropsychological point of view in order to improve clinical diagnostics. Methods: We compared the IQ-profile including GAI, OPIE IV-premorbid IQ and deterioration-scores of 21 epilepsy patients with ACA with 21 matched epilepsy patients without ACA (Epilepsy Controls) and 16 age- and education-matched Healthy Controls. Memory was also evaluated. Results: Premorbid IQs were equal in all groups...
April 27, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29701807/evidence-that-environmental-and-familial-risks-for-psychosis-additively-impact-a-multidimensional-subthreshold-psychosis-syndrome
#20
Lotta-Katrin Pries, Sinan Guloksuz, Margreet Ten Have, Ron de Graaf, Saskia van Dorsselaer, Nicole Gunther, Christian Rauschenberg, Ulrich Reininghaus, Rajiv Radhakrishnan, Maarten Bak, Bart P F Rutten, Jim van Os
Background: The observed link between positive psychotic experiences (PE) and psychosis spectrum disorder (PSD) may be stronger depending on concomitant presence of PE with other dimensions of psychopathology. We examined whether the effect of common risk factors for PSD on PE is additive and whether the impact of risk factors on the occurrence of PE depends on the co-occurrence of other symptom dimensions (affective dysregulation, negative symptoms, and cognitive alteration). Method: Data from the Netherlands Mental Health Survey and Incidence Study 2 were used...
April 25, 2018: Schizophrenia Bulletin
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