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https://www.readbyqxmd.com/read/28926187/synthesis-of-a-metallo-iminosilane-via-a-silanone-metal-%C3%AF-complex
#1
Matthias Driess, Terrance J Hadlington, Tibor Szilvási
Facile oxygenation of the acyclic amido chlorosilylene-bis(N-heterocyclic carbene) Ni0 complex 1, [{N(Dipp)(SiMe3)ClSi:→Ni(NHC)2] (Dipp = 2,6-Pri2C6H4; N-heterocyclic carbene = C[(Pri)NC(Me)]2) with N2O furnishes the first Si-metallo-iminosilane complex, [DippN=Si(OSiMe3)Ni(Cl)(NHC)2] 3, in a cascade of rearrangement reactions. Markedly, the formation of 3 ensues via a silanone (Si=O)-Ni pi-complex 2 as the initial product, which has been predicted by DFT calculations and could be observed spectroscopically...
September 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28917173/synthetic-iron-hydr-oxide-glucose-associations-in-subsurface-soil-effects-on-decomposability-of-mineral-associated-carbon
#2
R C Porras, C E Hicks Pries, M S Torn, P S Nico
Soils are a globally important reservoir of organic carbon. There is a growing understanding that interactions with soil mineral phases contribute to the accumulation and retention of otherwise degradable organic matter (OM) in soils and sediments. However, the bioavailability of organic compounds in mineral-organic-associations (MOAs), especially under varying environmental conditions is not well known. To assess the impact of mineral association and warming on the decomposition of an easily respirable organic substrate (glucose), we conducted a series of laboratory incubations at different temperatures with field-collected soils from 10 to 20cm, 50-60cm, and 80-90cm depth...
September 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28915609/polymorphisms-of-pri-mir-219-1-are-associated-with-the-susceptibility-and-prognosis-of-non-small-cell-lung-cancer-in-a-northeast-chinese-population
#3
Chang Zheng, Xuelian Li, Lingzi Xia, Xue Fang, Xiaowei Quan, Zhihua Yin, Yuxia Zhao, Baosen Zhou
Occurrence and development of non-small cell lung cancer (NSCLC) is a complex process affected both by gene and environment. Single nucleotide polymorphisms (SNPs) in microRNAs' (miRNAs) biogenesis influenced the expression of mature miRNAs, further had an impact on risk of NSCLC. Our study focused on the correlation between rs213210, rs421446 or rs107822 polymorphisms in pri-miR-219-1 and susceptibility or prognosis of NSCLC in Chinese. A case-control study of 405 new-diagnosis patients and 405 controls was performed...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28898705/relationships-of-bullying-involvement-with-intelligence-attention-and-executive-function-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#4
Tai-Ling Liu, Nai-Wen Guo, Ray C Hsiao, Huei-Fan Hu, Cheng-Fang Yen
This study investigated the relationship of bullying victimization and perpetration with the levels of intelligence, attention, and executive function in children who had received a diagnosis of attention-deficit/hyperactivity disorder (ADHD). The experiences of bullying involvement in 105 children with ADHD were assessed using the Chinese version of the School Bullying Experience Questionnaire. Their scores for four intelligence indexes on the Wechsler Intelligence Scale for Children 4th Edition-Chinese version were determined...
September 8, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28892844/are-optical-indices-good-proxies-of-seasonal-changes-in-carbon-fluxes-and-stress-related-physiological-status-in-a-beech-forest
#5
E Nestola, A Scartazza, D Di Baccio, A Castagna, A Ranieri, M Cammarano, F Mazzenga, G Matteucci, C Calfapietra
This study investigates the functionality of a Mediterranean-mountain beech forest in Central Italy using simultaneous determinations of optical measurements, carbon (C) fluxes, leaf eco-physiological and biochemical traits during two growing seasons (2014-2015). Meteorological variables showed significant differences between the two growing seasons, highlighting a heat stress coupled with a reduced water availability in mid-summer 2015. As a result, a different C sink capacity of the forest was observed between the two years of study, due to the differences in stressful conditions and the related plant physiological status...
September 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28891214/non-redundant-functions-of-the-dimeric-aba-receptor-bdpyl1-in-the-grass-brachypodium
#6
Oded Pri-Tal, Lidor Shaar-Moshe, Gil Wiseglass, Zvi Peleg, Assaf Mosquna
Abiotic stresses have severe detrimental effects on agricultural productivity worldwide. ABA levels rise in response to abiotic stresses, and play a role in coordinating physiological responses. ABA elicits its effects by binding a family of soluble receptors, increasing affinity of the receptors to type 2C phosphatases (PP2Cs) leading to phosphatase inhibition. In the current study, we conducted a comprehensive analysis of the ABA signaling pathway in the cereal model grass Brachypodium distachyon. The Brachypodium genome encodes a family of ten functionally conserved ABA receptors...
September 11, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28886115/androgen-receptor-mediated-downregulation-of-microrna-221-and-222-in-castration-resistant-prostate-cancer
#7
Bin Gui, Chen-Lin Hsieh, Philip W Kantoff, Adam S Kibel, Li Jia
MicroRNAs (miRNAs) play important roles in cancer formation and progression by suppressing the production of key functional proteins at the post-transcriptional level in a sequence-specific manner. While differential expression of miRNAs is widely observed in cancers including prostate cancer (PCa), how these miRNAs are transcriptionally regulated is largely unknown. MiRNA-221 and miRNA-222 (miR-221/-222) are well-established oncogenes and overexpressed in breast, liver, pancreas, and lung cancer, but their expression and biological functions in PCa remain controversial...
2017: PloS One
https://www.readbyqxmd.com/read/28874081/physicochemical-investigation-and-in-vivo-activity-of-anti-malarial-drugs-co-loaded-in-tween-80-niosomes
#8
Miloni Thakkar, Brijesh S
Drugs used for the treatment and prevention of malaria are often plagued by the problem of development of resistance. This has hampered their therapeutic efficiency and rendered them ineffective for monotherapy. However, if re-packaged and combined properly, many of these neglected anti-malarial drugs can possibly find their way back into the treatment regime. The present study evaluates the use of curcumin (CC) and primaquine (PRI) as an anti-malarial combination, packaged within niosomes, in comparison to their respective monotherapy options...
September 5, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28872351/neuropsychological-outcome-of-children-with-traumatic-brain-injury-and-its-association-with-late-magnetic-resonance-imaging-findings-a-cohort-study
#9
Daniele S J Volpe, Nátali C A C Oliveira, A Carlos Santos, Maria B M Linhares, Ana P C P Carlotti
OBJECTIVES: To evaluate neuropsychological outcome after traumatic brain injury (TBI) and its association with trauma severity and late magnetic resonance imaging (MRI) findings. METHODS: Prospective cohort study of patients with TBI admitted to the paediatric intensive care unit over 5 years. Trauma severity was determined by Glasgow Coma Scale (GCS), neurological outcome by King's Outcome Scale for Childhood Head Injury (KOSCHI) and neuropsychological outcome by Wechsler Intelligence Scale for Children - Fourth Edition...
September 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28846091/neat1-scaffolds-rna-binding-proteins-and-the-microprocessor-to-globally-enhance-pri-mirna-processing
#10
Li Jiang, Changwei Shao, Qi-Jia Wu, Geng Chen, Jie Zhou, Bo Yang, Hairi Li, Lan-Tao Gou, Yi Zhang, Yangming Wang, Gene W Yeo, Yu Zhou, Xiang-Dong Fu
MicroRNA (miRNA) biogenesis is known to be modulated by a variety of RNA-binding proteins (RBPs), but in most cases, individual RBPs appear to influence the processing of a small subset of target miRNAs. Here, we report that the RNA-binding NONO-PSF heterodimer binds a large number of expressed pri-miRNAs in HeLa cells to globally enhance pri-miRNA processing by the Drosha-DGCR8 Microprocessor. NONO and PSF are key components of paraspeckles organized by the long noncoding RNA (lncRNA) NEAT1. We further demonstrate that NEAT1 also has a profound effect on global pri-miRNA processing...
August 28, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28844410/safety-tolerability-and-preliminary-efficacy-of-the-anti-fibrotic-small-molecule-pri-724-a-cbp-%C3%AE-catenin-inhibitor-in-patients-with-hepatitis-c-virus-related-cirrhosis-a-single-center-open-label-dose-escalation-phase-1-trial
#11
Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa, Takuji Okusaka, Satoshi Morita, Kazuaki Inoue, Tatsuya Kanto, Koji Todaka, Yoichi Nakanishi, Michinori Kohara, Masashi Mizokami
BACKGROUND: There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator of Wnt signaling, in patients with HCV cirrhosis. METHODS: In this single-center, open-label, phase 1 trial, we sequentially enrolled patients with HCV cirrhosis who were classified as Child-Pugh (CP) class A or B. PRI-724 was administered as a continuous intravenous infusion of 10, 40, or 160mg/m(2)/day for six cycles of 1week on and 1week off...
August 19, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28839466/the-grna-mirna-grna-ternary-cassette-combining-crispr-cas9-with-rnai-approach-strongly-inhibits-hepatitis-b-virus-replication
#12
Jie Wang, Ran Chen, Ruiyang Zhang, Shanlong Ding, Tianying Zhang, Quan Yuan, Guiwen Guan, Xiangmei Chen, Ting Zhang, Hui Zhuang, Frederick Nunes, Timothy Block, Shuang Liu, Zhongping Duan, Ningshao Xia, Zhongwei Xu, Fengmin Lu
The CRISPR/Cas9 system is a novel genome editing technology which has been successfully used to inhibit HBV replication. Here, we described a novel gRNA-microRNA (miRNA)-gRNA ternary cassette driven by a single U6 promoter. With an anti-HBV pri-miR31 mimic integrated between two HBV-specific gRNAs, both gRNAs could be separated from the long transcript of gRNA-miR-HBV-gRNA ternary cassette through Drosha/DGCR8 processing. The results showed that the gRNA-miR-HBV-gRNA ternary cassette could efficiently express two gRNAs and miR-HBV...
2017: Theranostics
https://www.readbyqxmd.com/read/28832672/white-noise-speech-illusion-and-psychosis-expression-an-experimental-investigation-of-psychosis-liability
#13
Lotta-Katrin Pries, Sinan Guloksuz, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Marieke Wichers, Claudia J P Simons, Bart P F Rutten, Jim van Os
BACKGROUND: An association between white noise speech illusion and psychotic symptoms has been reported in patients and their relatives. This supports the theory that bottom-up and top-down perceptual processes are involved in the mechanisms underlying perceptual abnormalities. However, findings in nonclinical populations have been conflicting. OBJECTIVES: The aim of this study was to examine the association between white noise speech illusion and subclinical expression of psychotic symptoms in a nonclinical sample...
2017: PloS One
https://www.readbyqxmd.com/read/28831895/healthcare-assistant-fined-for-accessing-medical-records-of-friends-and-colleagues
#14
(no author information available yet)
NHS staff are being reminded of the potentially serious consequences of prying into patients' records without a valid reason after a healthcare assistant (HCA) secretly accessed medical information on 29 people.
August 23, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28821572/rolling-neutrophils-form-tethers-and-slings-under-physiologic-conditions-in-vivo
#15
Alex Marki, Konrad Buscher, Zbigniew Mikulski, Axel Pries, Klaus Ley
Human and mouse neutrophils are known to form tethers when rolling on selectins in vitro. Tethers are ∼0.2 μm thin, ∼5-10 μm-long structures behind rolling cells that can swing around to form slings that serve as self-adhesive substrates. Here, we developed a mouse intravital imaging method, where the neutrophil surface is labeled by injecting fluorescently labeled mAb to Ly-6G. Venules in the cremaster muscle of live mice were imaged at a high frame rate using a confocal microscope equipped with a fast resonant scanner...
August 18, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28819307/crispr-cas9-editing-reveals-novel-mechanisms-of-clustered-microrna-regulation-and-function
#16
Lazaros Lataniotis, Andreas Albrecht, Fatma O Kok, Clinton A L Monfries, Lorena Benedetti, Nathan D Lawson, Simon M Hughes, Kathleen Steinhofel, Manuel Mayr, Anna Zampetaki
MicroRNAs (miRNAs) are important regulators of diverse physiological and pathophysiological processes. MiRNA families and clusters are two key features in miRNA biology. Here we explore the use of CRISPR/Cas9 as a powerful tool to delineate the function and regulation of miRNA families and clusters. We focused on four miRNA clusters composed of miRNA members of the same family, homo-clusters or different families, hetero-clusters. Our results highlight different regulatory mechanisms in miRNA cluster expression...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28809937/understanding-large-scale-long-term-larval-connectivity-patterns-the-case-of-the-northern-line-islands-in-the-central-pacific-ocean
#17
Lorenzo Mari, Luca Bonaventura, Andrea Storto, Paco Melià, Marino Gatto, Simona Masina, Renato Casagrandi
Protecting key hotspots of marine biodiversity is essential to maintain ecosystem services at large spatial scales. Protected areas serve not only as sources of propagules colonizing other habitats, but also as receptors, thus acting as protected nurseries. To quantify the geographical extent and the temporal persistence of ecological benefits resulting from protection, we investigate larval connectivity within a remote archipelago, characterized by a strong spatial gradient of human impact from pristine to heavily exploited: the Northern Line Islands (NLIs), including part of the Pacific Remote Islands Marine National Monument (PRI-MNM)...
2017: PloS One
https://www.readbyqxmd.com/read/28796488/direct-interaction-of-chivosazole-f-with-actin-elicits-cell-responses-similar-to-latrunculin-a-but-distinct-from-chondramide
#18
Ireos Filipuzzi, Jason Ray Thomas, Verena Pries, David Estoppey, Michael Salcius, Christian Studer, Markus Schirle, Dominic Hoepfner
The microbial metabolite Chivosazole F has been described to affect the cytoskeleton and to inhibit actin polymerization in vitro. Applying orthogonal genomic and proteomics approaches, we now show for the first time that Chivosazole F exerts its effect by directly interacting with actin and demonstrate the cellular impact of Chivosazole F in an unbiased, genome-wide context in yeast and in mammalian cells. Furthermore, mutation-based resistance mapping identifies two SNPs located in the putative Chivosazole F binding site of actin...
August 15, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28751904/canopy-vegetation-indices-from-in-situ-hyperspectral-data-to-assess-plant-water-status-of-winter-wheat-under-powdery-mildew-stress
#19
Wei Feng, Shuangli Qi, Yarong Heng, Yi Zhou, Yapeng Wu, Wandai Liu, Li He, Xiao Li
Plant disease and pests influence the physiological state and restricts the healthy growth of crops. Physiological measurements are considered the most accurate way of assessing plant health status. In this paper, we researched the use of an in situ hyperspectral remote sensor to detect plant water status in winter wheat infected with powdery mildew. Using a diseased nursery field and artificially inoculated open field experiments, we detected the canopy spectra of wheat at different developmental stages and under different degrees of disease severity...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28743663/the-variant-of-pri-mir-26a-1-polymorphism-is-associated-with-decreased-risk-of-betel-quid-related-oral-premalignant-lesions-and-oral-squamous-cell-carcinoma
#20
Cheng-Mei Yang, Chien-Chou Chen, Yu-Kai Tseng, Sin-Jhih Huang, Huei-Han Liou, Yi-Cheng Lee, Jang-Hwa Lee, Jyh-Seng Wang, Hung-Chih Chen, Chao-Chuan Chi, Bor-Hwang Kang, Yun-Chung Lin, Kuo-Wang Tsai, Luo-Ping Ger
OBJECTIVES: This case-control study evaluated the association of the single nucleotide polymorphism rs7372209 (T>C) in pri-mir-26a-1 with the risk and progression of betel quid (BQ)-related oral premalignant lesions (OPLs) and oral squamous cell carcinoma (OSCC). STUDY DESIGN: In total, 597 BQ chewers were recruited: 196 healthy controls, 241 patients with OPLs, and 160 patients with OSCC. Genotypes were determined using the TaqMan real-time assay. RESULTS: The C/T + T/T genotypes and T allele in pri-mir-26a-1 were correlated with a decreased risk of BQ-related OPLs (P = ...
June 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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