keyword
MENU ▼
Read by QxMD icon Read
search

Pri

keyword
https://www.readbyqxmd.com/read/29345296/vitamin%C3%A2-d-derivatives-potentiate-the-anticancer-and-anti-angiogenic-activity-of-tyrosine-kinase-inhibitors-in-combination-with-cytostatic-drugs-in-an-a549-non-small-cell-lung-cancer-model
#1
Ewa Maj, Beata Filip-Psurska, Magdalena Milczarek, Mateusz Psurski, Andrzej Kutner, Joanna Wietrzyk
Numerous in vitro and in vivo studies have demonstrated that calcitriol [1,25(OH)2D3] and different vitamin D analogs possess antineoplastic activity, regulating proliferation, differentiation and apoptosis, as well as angiogenesis. Vitamin D compounds have been shown to exert synergistic effects when used in combination with different agents used in anticancer therapies in different cancer models. The aim of this study was to evaluate the mechanisms of the cooperation of the vitamin D compounds [1,24(OH)2D3 (PRI‑2191) and 1,25(OH)2D3] with tyrosine kinase inhibitors (imatinib and sunitinib) together with cytostatics (cisplatin and docetaxel) in an A549 non-small cell lung cancer model...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29343953/impact-of-acute-exacerbations-on-platelet-reactivity-in-chronic-obstructive-pulmonary-disease-patients
#2
Mariana Muñoz-Esquerre, José Luis Ferreiro, Daniel Huertas, Ana Lucrecia Marcano, Marta López-Sánchez, Gerard Roura, Joan Antoni Gómez-Hospital, Jordi Dorca, Angel Cequier, Salud Santos
Background: A higher risk of atherothrombotic cardiovascular events, which are platelet-driven processes, has been described during acute exacerbations of chronic obstructive pulmonary disease (AECOPD). However, the relevance of platelet reactivity during AECOPD and whether this is affected by antiplatelet agents are not fully elucidated to date. This study aimed to evaluate whether platelet reactivity is augmented during an exacerbation in COPD patients with and without antiplatelet therapy and its association with systemic inflammatory parameters...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29329963/switch-to-ticagrelor-in-critical-limb-ischemia-antiplatelet-study-stt-clips
#3
Leonardo C Clavijo, Ashwat Dhillon, Noor Al-Asady, Ray V Matthews, Jorge Caro, Han Tun, Vincent Rowe, David M Shavelle
OBJECTIVE: To investigate platelet reactivity in patients with critical limb ischemia (CLI) after switching from clopidogrel to ticagrelor. BACKGROUND: High on-treatment platelet reactivity (HPR) is highly prevalent in patients with CLI treated with clopidogrel. The effect of ticagrelor in patients with CLI is not known, however. METHODS: We performed P2Y12 platelet receptor inhibition studies (VASP and VerifyNow) in 50 patients with CLI. Tests were performed before and 6±1h after daily 75mg clopidogrel dose...
September 5, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29321871/leaf-trait-variations-associated-with-habitat-affinity-of-tropical-karst-tree-species
#4
Nalaka Geekiyanage, Uromi Manage Goodale, Kunfang Cao, Kaoru Kitajima
Karst hills, that is, jagged topography created by dissolution of limestone and other soluble rocks, are distributed extensively in tropical forest regions, including southern parts of China. They are characterized by a sharp mosaic of water and nutrient availability, from exposed hilltops with poor soil development to valleys with occasional flooding, to which trees show species-specific distributions. Here we report the relationship of leaf functional traits to habitat preference of tropical karst trees. We described leaf traits of 19 tropical tree species in a seasonal karst rainforest in Guangxi Province, China, 12 species in situ and 13 ex situ in a non-karst arboretum, which served as a common garden, with six species sampled in both...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29306967/identification-of-tarsal-less-peptides-from-the-silkworm-bombyx-mori
#5
Guangli Cao, Yongchang Gong, Xiaolong Hu, Min Zhu, Zi Liang, Lixu Huang, Lei Yu, Jian Xu, Kun Li, Mian Sahib Zar, Renyu Xue, Chengliang Gong
The polycistronic and non-canonical gene tarsal-less (tal, known as pri) was reported to be required for embryonic and imaginal development in Drosophila; however, there are few reports of the tal gene in the silkworm Bombyx mori. Here, we cloned a tal-like (Bmtal) gene, and a sequence analysis showed that the Bmtal cDNA (1661 bp) contains five small open reading frames (smORFs) (A1, A2, A3, A4, and B) that encode short peptides of 11-12 (A1-A4) amino acid residues containing an LDPTG(E)L(Q)(V)Y motif that is conserved in Drosophila Tal, as well as a 32-amino-acid B peptide...
January 6, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29306350/effect-of-condensed-tannins-in-rations-of-lactating-dairy-cows-on-production-variables-and-nitrogen-use-efficiency
#6
K Gerlach, M Pries, E Tholen, A J Schmithausen, W Büscher, K-H Südekum
The objective of this study was to evaluate the effect of supplemented condensed tannins (CT) from the bark of the Black Wattle tree (Acacia mearnsii) on production variables and N use efficiency in high yielding dairy cows. A feeding trial with 96 lactating German Holstein cows was conducted for a total of 169 days, divided into four periods. The animals were allotted to two groups (control (CON) and experimental (EXP) group) according to milk yield in previous lactation, days in milk (98), number of lactations and BW...
January 8, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29304813/the-association-between-pre-mir-27a-rs895819-polymorphism-and-myocardial-infarction-risk-in-a-chinese-han-population
#7
Meng-Yun Cai, Jie Cheng, Meng-Yuan Zhou, Li-Li Liang, Si-Min Lian, Xiao-Shan Xie, Shun Xu, Xinguang Liu, Xing-Dong Xiong
BACKGROUND: Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population...
January 6, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29298094/a-rare-rs139365823-polymorphism-in-pre-mir-138-is-associated-with-risk-of-congenital-heart-disease-in-a-chinese-population
#8
Xiaobo Gao, Liping Yang, Haiyan Luo, Fengwei Tan, Xu Ma, Cailing Lu
miR-138 modulates cardiac morphogenesis in zebrafish. We explored whether a genetic polymorphism in miR-138 might contribute to the occurrence of sporadic congenital heart disease (CHD) and the potential mechanism. We performed a case-control study consisting of 857 CHD cases and 938 non-CHD controls by genotyping miR-138 in a Chinese population. Two SNPs, including rare rs139365823 located in the pre-miR-138 sequence and rs76987351 located in the pri-miR-138 sequence, were identified by sequencing miR-138...
January 3, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29284691/a-to-i-editing-of-microrna-487b-alters-target-gene-selection-after-ischemia-and-promotes-neovascularization
#9
Reginald V van der Kwast, Eva van Ingen, Laura Parma, Hendrika A Peters, Paul H Quax, A Y Nossent
Rationale: Adenosine-to-inosine (A-to-I) editing of microRNAs has the potential to cause a shift in target-site selection. 2'-O-ribose-methylation (2'OMe) of adenosine residues however, has been shown to inhibit A-to-I-editing. Objective: To investigate whether angiomiR miR487b is subject to A-to-I-editing and/or 2'OMe during neovascularization. Methods and Results: cDNA was prepared from C57BL/6-mice subjected to hindlimb ischemia. Using Sanger-sequencing and endonuclease digestion, we identified and validated A-to-I-editing of the miR487b seed-sequence...
December 28, 2017: Circulation Research
https://www.readbyqxmd.com/read/29275948/item-method-directed-forgetting-effects-at-retrieval
#10
Tracy L Taylor, Laura Cutmore, Lotta Pries
In an item-method directed forgetting paradigm, words are presented one at a time, each followed by an instruction to Remember or Forget; a directed forgetting effect is measured as better subsequent memory for Remember words than Forget words. The dominant view is that the directed forgetting effect arises during encoding due to selective rehearsal of Remember over Forget items. In three experiments we attempted to falsify a strong view that directed forgetting effects in recognition are due only to encoding mechanisms when an item method is used...
December 22, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/29273482/a-novel-host-protein-assay-outperforms-routine-parameters-for-distinguishing-between-bacterial-and-viral-lower-respiratory-tract-infections
#11
Michal Stein, Shelly Lipman-Arens, Kfir Oved, Asi Cohen, Ellen Bamberger, Roy Navon, Olga Boico, Tom Friedman, Liat Etshtein, Meital Paz, Tanya M Gottlieb, Or Kriger, Yura Fonar, Ester Pri-Or, Renata Yacobov, Yaniv Dotan, Amit Hochberg, Moti Grupper, Irina Chistyakov, Israel Potasman, Isaac Srugo, Eran Eden, Adi Klein
Bacterial and viral lower respiratory tract infections (LRTIs) are often clinically indistinguishable, leading to antibiotic overuse. We compared the diagnostic accuracy of a new assay that combines 3 host-biomarkers (TRAIL, IP-10, CRP) with parameters in routine use to distinguish bacterial from viral LRTIs. Study cohort included 184 potentially eligible pediatric and adult patients. Reference standard diagnosis was based on adjudication by an expert panel following comprehensive clinical and laboratory investigation (including respiratory PCRs)...
November 24, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29250926/subepidermal-moisture-detection-of-heel-pressure-injury-the-pressure-ulcer-detection-study-outcomes
#12
Barbara M Bates-Jensen, Heather E McCreath, Gojiro Nakagami, Anabel Patlan
We examined subepidermal moisture (SEM) and visual skin assessment of heel pressure injury (PrI) among 417 nursing home residents in 19 facilities over 16 weeks. Participants were older (mean age 77 years), 58% were female, over half were ethnic minorities (29% African American, 12% Asian American, 21% Hispanic), and at risk for PrI (mean Braden Scale Risk score = 15.6). Blinded concurrent visual assessments and SEM measurements were obtained at heels weekly. Visual skin damage was categorised as normal, erythema, stage 1 PrI, deep tissue injury (DTI) or stage 2 or greater PrI...
December 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29250169/therapeutic-strategies-against-cancer-stem-cells-in-human-colorectal-cancer
#13
Magdalena Szaryńska, Agata Olejniczak, Jarosław Kobiela, Piotr Spychalski, Zbigniew Kmieć
Colorectal cancer (CRC) is the third most frequent malignancy and represents the fourth most common cause of cancer-associated mortalities in the world. Despite many advances in the treatment of CRC, the 5-year survival rate of patients with CRC remains unsatisfactory due to tumor recurrence and metastases. Recently, cancer stem cells (CSCs), have been suggested to be responsible for the initiation and relapse of the disease, and have been identified in CRC. Due to their basic biological features, which include self-renewal and pluripotency, CSCs may be novel therapeutic targets for CRC and other cancer types...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29248466/leptin-suppresses-microrna-122-promoter-activity-by-phosphorylation-of-foxo1-in-hepatic-stellate-cell-contributing-to-leptin-promotion-of-mouse-liver-fibrosis
#14
Qing Cao, Xiaofei Zhu, Xuguang Zhai, Li Ji, Fangyun Cheng, Yiqi Zhu, Pengfei Yu, Yajun Zhou
Adipocytokine leptin promotes hepatic stellate cell (HSC) activation (a key step in liver fibrogenesis) and liver fibrosis. microRNA-122 (miR-122) is the most abundant liver-specific miRNA and was demonstrated to inhibit liver fibrosis and reduced HSC proliferation. Our previous study revealed that leptin reduced miR-122 level in HSCs. This study was aimed to investigate whether leptin affected miR-122 promoter and the underlying mechanisms in HSCs. Results showed that leptin inhibited miR-122 promoter activity...
December 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29240233/blue-honeysuckle-lonicera-caerulea-subsp-edulis-turcz-ex-herder-hult%C3%A3-n-berries-and-changes-in-their-ingredients-across-different-locations
#15
Mateja Senica, Martina Bavec, Franci Stampar, Maja Mikulic-Petkovsek
BACKGROUND: Interest in organic blue honeysuckle berries has increased in recent years. They are rich in various health promoting compounds, which are sensitive to different environmental factors and are modified during the growing season. RESULTS: Honeysuckle berries from different locations significantly differed in contents of primary and secondary metabolites. The location Ogulin, with the highest altitude and, consequently, high UV-radiation, had the highest phenolics content (259...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29233923/the-landscape-of-mirna-editing-in-animals-and-its-impact-on-mirna-biogenesis-and-targeting
#16
Lishi Li, Yulong Song, Xinrui Shi, Jianheng Liu, Shaolei Xiong, Wanying Chen, Qiang Fu, Zichao Huang, Nannan Gu, Rui Zhang
Adenosine-to-inosine (A-to-I) RNA editing regulates miRNA biogenesis and function. To date, fewer than 160 miRNA editing sites have been identified. Here, we present a quantitative atlas of miRNA A-to-I editing through the profiling of 201 pri-miRNA samples and 4694 mature miRNA samples in human, mouse, and Drosophila. We identified 4162 sites present in ∼80% of the pri-miRNAs and 574 sites in mature miRNAs. miRNA editing is prevalent in many tissue types in human. However, high-level editing is mostly found in neuronal tissues in mouse and Drosophila Interestingly, the edited miRNAs in neuronal and non-neuronal tissues in human gain two distinct sets of new targets, which are significantly associated with cognitive and organ developmental functions, respectively...
December 12, 2017: Genome Research
https://www.readbyqxmd.com/read/29231508/-effects-of-tooth-extraction-under-acupuncture-anesthesia
#17
Jiang Pan, Bilian Lin, Ming Chen, Wei Zhang, Bidan Lou
OBJECTIVE: To compare the effects for tooth extraction between acupuncture anesthesia and drug local block anesthesia. METHODS: Sixty patients were randomly assigned into an acupuncture group and a drug group, 30 cases in each one. Acupuncture was applied at Hegu (LI 4), Neiting (ST 44) and the affected side Xiaguan (ST 7), and Jiache (ST 6), etc. Arrachement was used after deqi and the needles were retained for 10 min after tooth extraction in the acupuncture group...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29222942/microbial-communities-in-natural-rubber-coagula-during-maturation-impacts-on-technological-properties-of-dry-natural-rubber
#18
Mélanie Salomez, Maeva Subileau, Tatiana Vallaeys, Sylvain Santoni, Fréderic Bonfils, Jérôme Sainte-Beuve, Jutharat Intapun, Françoise Granet, Laurent Vaysse, Éric Dubreucq
AIM: To characterize microbial communities present in natural rubber coagula from Hevea brasiliensis latex during maturation and identify microbial taxa (bacteria and fungi) having an impact on dry natural rubber properties. METHODS AND RESULTS: Microbial community dynamics in natural rubber coagula maturated under controlled conditions were compared and related with the evolution of dry natural rubber properties. The pyrosequencing of 16S (119,837 effective reads) and 18S (131,879 effective reads) rRNA gene regions was performed on 21 samples covering different maturation times and two aeration conditions...
December 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29221961/prevalence-of-high-on-treatment-aspirin-and-clopidogrel-platelet-reactivity-in-patients-with-critical-limb-ischemia
#19
Leonardo C Clavijo, Noor Al-Asady, Ashwat Dhillon, Ray V Matthews, Jorge Caro, Han Tun, Vincent Rowe, David M Shavelle
OBJECTIVES: The goal of this study is to establish the prevalence of high on-treatment platelet reactivity to aspirin (HPRA) and clopidogrel (HPRC) in patients with critical limb ischemia (CLI). BACKGROUND: CLI is associated with an increased risk of death and cardiovascular events. Unlike other patient populations with atherosclerotic cardiovascular disease, previous studies failed to demonstrate a benefit of antiplatelet therapy in patients with CLI. METHODS: From June 2014 to November 2016, we performed platelet reactivity studies for P2Y12 and thromboxane A2 (TXA2) inhibition in 100 CLI patients receiving daily treatment with aspirin and clopidogrel...
October 28, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29216416/illuminating-the-role-of-the-g%C3%AE-heterotrimeric-g-protein-subunit-rga1-in-regulating-photoprotection-and-photovoidance-in-rice
#20
Ángel Ferrero-Serrano, Zhao Su, Sarah M Assmann
We studied physiological mechanisms of photoavoidance and photoprotection of a dwarf rice mutant with erect leaves, d1, in which the RGA1 gene, which encodes the Gα subunit of the heterotrimeric G protein, is non-functional. d1 leaves exhibit lower leaf temperature and higher Photochemical Reflectance Index (PRI) relative to wild-type (WT), indicative of increased photoavoidance and more efficient light harvesting. RNA-seq analysis of flag leaves revealed that mRNA levels of genes encoding HSPs, enzymes associated with chlorophyll breakdown, and ROS scavengers were down-regulated in d1...
December 7, 2017: Plant, Cell & Environment
keyword
keyword
50232
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"