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ppi vs histamine blockers

Gursimran Kochhar, Preston Edge, Courtney Blomme, Xian-Rui Wu, Rocio Lopez, Jean Ashburn, Bo Shen
Background: Clostridium difficile infection (CDI) is traditionally considered a colon-affecting disease with frequent pseudomembrane formation. However, multiple case reports have documented the existence of CDI in the small bowel, and the literature on outcome of C difficile enteropathy (CDE) is sparse. The aims of our study are to identify risk factors and to assess patient-related outcomes associated with CDE. Methods: This is a case-control study involving 112 patients at our tertiary care center...
January 18, 2018: Inflammatory Bowel Diseases
Daniel Gelfond, Sonya L Heltshe, Michelle Skalland, James E Heubi, Margaret Kloster, Daniel H Leung, Bonnie W Ramsey, Drucy Borowitz
OBJECTIVES: The aim of the study is to describe pancreatic enzyme practices during the first year of life in infants with cystic fibrosis (CF) and evaluate associations between dosing and outcomes, including growth and gastrointestinal (GI) symptoms. METHODS: We analyzed data from a subset of infants who were in a prospective cohort study conducted at 28 US CF centers. Anthropometric measurements and medications were recorded at each visit. Diaries with infant diet, pancreatic enzyme replacement therapy (PERT) dosing, stool frequency and consistency, and pain were completed by a parent/guardian for 3 days before each visit...
April 2018: Journal of Pediatric Gastroenterology and Nutrition
W-C Chen, K-H Lin, Y-T Huang, T-J Tsai, W-C Sun, S-K Chuah, D-C Wu, P-I Hsu
BACKGROUND: Aspirin increases the risk of gastrointestinal bleeding. AIM: To investigate the risk of lower gastrointestinal bleeding (LGIB) in aspirin users. METHODS: Low-dose (75-325 mg daily) aspirin users and controls matched by age, gender and enrollment time in a 1:5 ratio were selected from 1 million randomly sampled subjects in the National Health Insurance Research Database of Taiwan. Cox proportional hazard regression models were developed to evaluate the predictors of LGIB with adjustments for age, gender, comorbidities including coronary artery disease, ischaemic stroke, diabetes, hypertension, chronic kidney disease, liver cirrhosis, chronic obstructive pulmonary disease, dyslipidemia, uncomplicated peptic ulcer disease, history of peptic ulcer bleeding, and concomitant use of clopidogrel, ticlopidine, warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 inhibitors, steroids, proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), nitrates, alendronate, selective serotonin reuptake inhibitors (SSRIs) and calcium channel blockers...
June 2017: Alimentary Pharmacology & Therapeutics
Bob Geng, Ami Thakor, Elisabeth Clayton, Lindsay Finkas, Marc A Riedl
BACKGROUND: Identification of factors adversely affecting the utility of allergy skin testing is important in optimizing patient care. Inpatient penicillin skin test data from 1997 through 2007 demonstrate that up to 20% of attempted penicillin skin tests are indeterminate owing to a negative histamine test response, despite exclusion of H1 antagonists. Critical illness, vasopressors, steroid use, and psychotropic medications have been postulated to influence outcomes, but large studies are lacking...
July 2015: Annals of Allergy, Asthma & Immunology
Yaron Arbel, Edo Y Birati, Ariel Finkelstein, Amir Halkin, Hanna Kletzel, Yigal Abramowitz, Shlomo Berliner, Varda Deutsch, Itzhak Herz, Gad Keren, Shmuel Banai
BACKGROUND: Concerns about an inhibitory effect of proton pump inhibitors (PPIs) on clopidogrel metabolism have been raised. Because the pharmacological effect of clopidogrel is dependent on genetically determined activity of the hepatic cytochrome P450 isoenzymes system, it is important to examine the interaction between different PPIs and high on-treatment platelet reactivity (HPR) after controlling for genetic variability. The aim of the study was to assess the effect of 2 PPIs and a histamine-2 (H2) receptor-blocker on platelet reactivity in a crossover trial where each patient was alternately treated with each drug...
June 2013: Clinical Cardiology
Sahil Khanna, Scott L Aronson, Patricia P Kammer, Larry M Baddour, Darrell S Pardi
OBJECTIVE: To evaluate the association of gastric acid suppression medications, including proton pump inhibitors and histamine type 2 blockers, with outcomes in patients with Clostridium difficile infection (CDI) in a population-based cohort. PATIENTS AND METHODS: To understand the association between acid suppression and outcomes in patients with CDI, we conducted a population-based study in Olmsted County, Minnesota, from January 1, 1991, through December 31, 2005...
July 2012: Mayo Clinic Proceedings
K Clark, L T Lam, S Gibson, D Currow
Aspiration of acid into the lungs is an infrequent but potentially devastating complication of general anaesthesia. Routine practice often includes use of pharmacological agents to reduce gastric volume and increase gastric pH. The aim of this study was to compare the net benefit of proton pump inhibitors with histamine 2 blockers in a meta-analysis. Electronic databases were searched for trials that compared ranitidine vs proton pump inhibitors in their effect on volume and pH of gastric fluid aspirates. We identified nine trials of which seven were suitable for meta-analysis...
June 2009: Anaesthesia
B R Dalton, T Lye-Maccannell, E A Henderson, D R Maccannell, T J Louie
BACKGROUND: Proton pump inhibitors (PPI) have been linked to higher risk of Clostridium difficile infection (CDI). The relevance of this association in hospitals with low disease activity, where an outbreak strain is nondominant, has been assessed in relatively few studies. AIM: To assess the association of PPI and CDI in a setting of low disease activity. METHODS: A retrospective cohort study was conducted at two hospitals. Patients admitted for > or = 7 days receiving antibiotics were included...
March 15, 2009: Alimentary Pharmacology & Therapeutics
P Juul-Hansen, A Rydning
BACKGROUND: It is questionable whether a symptomatic condition with few serious medical consequences requires proton pump inhibitor (PPI) treatment. If effective, a less-potent treatment may be preferable. AIM: To compare an H2-blocker in an effervescent formulation with a PPI in on-demand treatment of endoscopy-negative gastro-oesophageal reflux disease (GERD). METHODS: Included were patients with heartburn and/or acid regurgitation for at least 3 months duration, a negative endoscopy and a positive response to 7 days of lansoprazole 60 mg daily...
January 2009: Alimentary Pharmacology & Therapeutics
Shinichiro Tanaka, Kazuhiko Nishigaki, Shinsuke Ojio, Munenori Okubo, Shinji Yasuda, Yoshiyuki Ishihara, Tomoki Kubota, Nobuhiro Takasugi, Itta Kawamura, Takahiko Yamaki, Hiroaki Ushikoshi, Takuma Aoyama, Masanori Kawasaki, Genzou Takemura, Shinya Minatoguchi
BACKGROUND: Aspirin and anti-platelet drugs are used commonly for patients with coronary heart disease. Proton pump inhibitor (PPI) and high-dose H2-blocker were recommended for preventing NSAIDs-related ulcer. Previously H2-blocker reported to have some negative cardiovascular effects. Additionally, a recent in vitro study showed that PPI reduced cardiac contractility. In this study, we evaluated whether chronic administration of PPI and high-dose H2-blocker affects left ventricular function...
August 2008: Journal of Cardiology
S Iu Serebrova
The authors studied the duration of intragastric acid production at 20 mg of pariet in patients with hypergastric gastritis after determination of the individual type of parietal gastric cell reception. The study included 40 patients (12 women and 28 men aged 33.3 +/- 6.7 years). Predominant activity of H2 receptors was detected in 32 patients, while M-cholinoreceptor activity prevailed in six patients; in two patients receptor type was not defined. Latent period (3.1 +/- 0.5 hours), pH(max) (5.4 +/- 0.7), pH24h (3...
2007: Klinicheskaia Meditsina
E Rey, C Morena Elola-Olaso, F Rodríguez-Artalejo, G R Locke, M Diaz-Rubio
BACKGROUND: Overall success of prophylactic strategies against non-steroidal anti-inflammatory drug (NSAID) complications depends on the use of gastroprotective drugs. AIM: We examined the use of antisecretory drugs in NSAID users in the general population of Spain. PARTICIPANTS AND METHODS: In 2002, a phone interview was conducted with 2500 persons representative of the general population of Spain. Using a validated questionnaire, we asked about the use of NSAID, aspirin and antisecretory drugs, and history of digestive diseases...
December 2006: Alimentary Pharmacology & Therapeutics
P Kirchhoff, K Andersson, T Socrates, S Sidani, O Kosiek, J P Geibel
The gastric H+,K+-ATPase of the parietal cell is responsible for acid secretion in the stomach and is the main target in the pharmacological treatment of acid-related diseases. Omeprazole and other benzimidazole drugs, although having delayed efficacy if taken orally, have high success rates in the treatment of peptic ulcer disease. Potassium competitive acid blockers (P-CAB) compete with K+ for binding to the H+,K+-ATPase and thereby they inhibit acid secretion. In this study, the in vitro properties of AZD0865, a reversible H+,K+-ATPase inhibitor of gastric acid secretion, are described...
November 2006: American Journal of Physiology. Gastrointestinal and Liver Physiology
György Miklós Buzás, Jolán Józan
BACKGROUND: Meta-analyses evaluated several aspects of Helicobacter pylori eradication based on the randomised controlled trials. AIM: to perform a meta-analysis of the papers presented at the European Helicobacter Pylori Study Group and United European Gastroenterology Week meetings from 1997 to 2002. METHODS: Abstracts dealing with the eradication of Helicobacter pylori have been reviewed and the randomised, controlled studies from European countries were included...
October 3, 2004: Orvosi Hetilap
Alberto Pilotto, Marilisa Franceschi, Gioacchino Leandro, Francesco Paris, Valeria Niro, Maria Grazia Longo, Luigi Piero D'Ambrosio, Angelo Andriulli, Francesco Di Mario
BACKGROUND AND AIMS: Although the administration of gastroprotective drugs may reduce the risk of gastrointestinal (GI) bleeding due to intake of non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin during chronic treatment, no consensus exists as to whether such co-therapy is effective in short-term prevention, particularly in old age. The aim of our study was to evaluate the risk of bleeding associated with acute and chronic NSAID or aspirin therapy in elderly subjects, and the influence of gastroprotective treatment on such a risk...
December 2003: Aging Clinical and Experimental Research
Y Takeuchi, S Kitano, T Bandoh, T Matsumoto, D Baatar, S Kai
BACKGROUND: Gastric ulcer healing is delayed in patients with portal hypertension (PHT) and often responds poorly to histamine H(2) blockers. Although proton pump inhibitors are more effective anti-ulcer agents, there is little information regarding their efficacy for gastric ulcer in cases of PHT. Therefore, we investigated the effects of a proton pump inhibitor, omeprazole, on the healing of acetic-acid-induced gastric ulcer in PHT rats. METHODS: Animals studied were 80 male Sprague-Dawley rats aged 7 weeks, of which half underwent two-staged portal vein ligation (PHT rats) and half underwent a sham operation (SO rats)...
March 2003: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
M Lazzaroni, G Bianchi Porro
The use of specific agents to heal mucosal lesions or to prevent non-steroidal anti-inflammatory drug toxicity, has focused upon two approaches: replacement of prostaglandin deficiency and inhibition of acid secretion. Acid suppression with traditional ulcer healing doses of H2-blockers is effective in healing gastric and duodenal ulcers upon discontinuation of the offending drug. In the event the non-steroidal anti-inflammatory drug must be continued, the use of H2-blockers is associated with a decrease in the healing rate...
December 2001: Digestive and Liver Disease
G Leandro, A Pilotto, M Franceschi, T Bertin, E Lichino, F Di Mario
No consensus exists as to whether cotherapy is effective in the short-term prevention of severe NSAID-related gastroduodenal damage. The aim of this study was to provide a quantitative systematic review of the efficacy of gastroprotective drugs, such as misoprostol, H2-blockers, and proton pump inhibitors (PPI) in preventing the severe acute NSAID-related gastroduodenal damage. Placebo-controlled randomized clinical trials on the use of misoprostol, H2-blockers, and PPIs as preventative agents published between January 1986 and May 1999 were identified through Medline and reference lists from clinical reviews...
September 2001: Digestive Diseases and Sciences
M Lazzaroni, G Bianchi Porro
While the most effective strategy to prevent non-steroidal anti-inflammatory drug-related gastrointestinal toxicity is not to prescribe the medication, this option is often impractical. The use of specific agents to heal mucosal lesions or to prevent non-steroidal anti-inflammatory drug toxicity, has focused upon two approaches: replacement of prostaglandin deficiency and inhibition of acid secretion. Acid suppression with traditional ulcer healing doses of H2-blockers is effective in the cure of gastric and duodenal ulcers upon discontinuation of the offending drug...
1999: Italian Journal of Gastroenterology and Hepatology
C R Meier, H Jick
AIMS: Case-reports describing patients who developed a first episode of acute gout while being treated with the proton pump inhibitor omeprazole led us to compare incidence rates of newly diagnosed gout cases among omeprazole, ranitidine and cimetidine users. METHODS: We conducted a cohort study with a nested case-control analysis using the UK-based General Practitioner Research Database (GPRD). The study encompassed a cohort of more than 53,000 subjects who received some 185,000 prescriptions for the three study drugs...
August 1997: British Journal of Clinical Pharmacology
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