Travis M Rotterman, Zoë Haley-Johnson, Tana S Pottorf, Tavishi Chopra, Ethan Chang, Shannon Zhang, William M McCallum, Sarah Fisher, Haley Franklin, Myriam Alvarez, Timothy C Cope, Francisco J Alvarez
Microglia-mediated synaptic plasticity after CNS injury varies depending on injury severity, but the mechanisms that adjust synaptic plasticity according to injury differences are largely unknown. This study investigates differential actions of microglia on essential spinal motor synaptic circuits following different kinds of nerve injuries. Following nerve transection, microglia and C-C chemokine receptor type 2 signaling permanently remove Ia axons and synapses from the ventral horn, degrading proprioceptive feedback during motor actions and abolishing stretch reflexes...
February 15, 2024: Cell Reports