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https://www.readbyqxmd.com/read/27895569/influence-of-lumbar-muscle-fatigue-on-trunk-adaptations-during-sudden-external-perturbations
#1
Jacques Abboud, François Nougarou, Arnaud Lardon, Claude Dugas, Martin Descarreaux
Introduction: When the spine is subjected to perturbations, neuromuscular responses such as reflex muscle contractions contribute to the overall balance control and spinal stabilization mechanisms. These responses are influenced by muscle fatigue, which has been shown to trigger changes in muscle recruitment patterns. Neuromuscular adaptations, e.g., attenuation of reflex activation and/or postural oscillations following repeated unexpected external perturbations, have also been described. However, the characterization of these adaptations still remains unclear...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27891626/does-trans-spinal-and-local-dc-polarization-affect-presynaptic-inhibition-and-post-activation-depression
#2
D Kaczmarek, J Ristikankare, E Jankowska
Direct current (DC) polarization has been demonstrated to alleviate the effects of various deficits in the operation of the central nervous system. However, the effects of trans-spinal DC stimulation (tsDCS) have been investigated less extensively than the effects of transcranial DC stimulation (tDCS), and their cellular mechanisms have not been elucidated. The main objectives of this study were, therefore, to extend our previous analysis of DC effects on the excitability of primary afferents and synaptic transmission by examining the effects of DC on two spinal modulatory feed-back systems, presynaptic inhibition and post-activation depression, in an anaesthetized rat preparation...
November 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27882347/ml372-blocks-smn-ubiquitination-and-improves-spinal-muscular-atrophy-pathology-in-mice
#3
Mahlet B Abera, Jingbo Xiao, Jonathan Nofziger, Steve Titus, Noel Southall, Wei Zheng, Kasey E Moritz, Marc Ferrer, Jonathan J Cherry, Elliot J Androphy, Amy Wang, Xin Xu, Christopher Austin, Kenneth H Fischbeck, Juan J Marugan, Barrington G Burnett
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and one of the leading inherited causes of infant mortality. SMA results from insufficient levels of the survival motor neuron (SMN) protein, and studies in animal models of the disease have shown that increasing SMN protein levels ameliorates the disease phenotype. Our group previously identified and optimized a new series of small molecules, with good potency and toxicity profiles and reasonable pharmacokinetics, that were able to increase SMN protein levels in SMA patient-derived cells...
November 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27880894/requirement-for-dicer-in-maintenance-of-monosynaptic-sensory-motor-circuits-in-the-spinal-cord
#4
Fumiyasu Imai, Xiaoting Chen, Matthew T Weirauch, Yutaka Yoshida
In contrast to our knowledge of mechanisms governing circuit formation, our understanding of how neural circuits are maintained is limited. Here, we show that Dicer, an RNaseIII protein required for processing microRNAs (miRNAs), is essential for maintenance of the spinal monosynaptic stretch reflex circuit in which group Ia proprioceptive sensory neurons form direct connections with motor neurons. In postnatal mice lacking Dicer in proprioceptor sensory neurons, there are no obvious defects in specificity or formation of monosynaptic sensory-motor connections...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27880831/assessment-of-homonymous-recurrent-inhibition-during-voluntary-contraction-by-conditioning-nerve-stimulation
#5
Sidney Grosprêtre, Julien Duclay, Alain Martin
In humans, the amount of spinal homonymous recurrent inhibition during voluntary contraction is usually assessed by using a peripheral nerve stimulation paradigm. This method consists of conditioning the maximal M-wave (SM stimulus) with prior reflex stimulation (S1), with 10 ms inter-stimulus interval (ISI). The decrease observed between unconditioned (S1 only) and conditioned (S1+SM) reflex size is then attributed to recurrent inhibition. However, during a voluntary contraction, a superimposed SM stimulation leads to a maximal M-wave followed by a voluntary (V) wave at similar latency than the H-reflex...
2016: PloS One
https://www.readbyqxmd.com/read/27837170/differential-contributions-of-vasopressin-v1a-and-oxytocin-receptors-in-the-amygdala-to-pain-related-behaviors-in-rats
#6
Bryce Cragg, Guangchen Ji, Volker Neugebauer
Neuroplastic changes in the amygdala account for emotional-affective aspects of pain and involve neuropeptides such as calcitonin gene-related peptide and corticotropin-releasing factor. Another neuropeptide system, central arginine vasopressin, has been implicated in neuropsychiatric disorders, but its role in pain-related emotional expression and neuroplasticity remains to be determined. Here, we tested the hypothesis that arginine vasopressin in the amygdala contributes to pain-related emotional-affective responses, using stereotaxic applications of arginine vasopressin and antagonists for G-protein coupled vasopressin V1A and oxytocin receptors in adult male Sprague-Dawley rats...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27834670/resistance-training-with-instability-is-more-effective-than-resistance-training-in-improving-spinal-inhibitory-mechanisms-in-parkinson-s-disease
#7
Carla Silva-Batista, Eugenia Casella Tavares Mattos, Daniel M Corcos, Jessica M Wilson, Charles J Heckman, Helcio Kanegusuku, Maria Elisa Pimentel Piemonte, Marco Túlio de Mello, Claudia Lucia de Moraes Forjaz, Hamilton Roschel, Valmor Alberto Tricoli, Carlos Ugrinowitsch
BACKGROUND: This study assessed: 1) the effects of 12 weeks of resistance training (RT) and resistance training with instability (RTI) on presynaptic inhibition (PSI) and disynaptic reciprocal inhibition (DRI) of patients with Parkinson's disease (PD); 2) the effectiveness of RT and RTI in moving PSI and DRI values of patients towards values of age-matched healthy controls (HC [Z-score analysis]); and 3) associations between PSI and DRI changes and clinical outcomes changes previously published...
November 10, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27834583/spinal-cord-injury-and-seated-postural-control-a-test-of-the-rambling-and-trembling-hypothesis
#8
Sunghoon Shin, Jacob J Sosnoff
Rambling-trembling analysis separates the center of pressure (COP) into two components: the rambling component (RM: supraspinal) and trembling component (TM: muscle stiffness/reflex). We hypothesized that persons with spinal cord injury (SCI) would demonstrate decreased RM resulting from altered supraspinal processing and increased TM resulting from increased muscle stiffness. We also anticipated that the TM component would be greater in SCI patients with Harrington rods than in those without them. The seated postural control was assessed in 18 persons with spinal cord injury (SCI), comprising of 12 with and 6 without Harrington rods, and 18 age-matched controls...
November 11, 2016: Motor Control
https://www.readbyqxmd.com/read/27834292/mesenteric-vascular-dysregulation-and-intestinal-inflammation-accompanies-experimental-spinal-cord-injury
#9
Emily M Besecker, Gina M Deiter, Nicole Pironi, Timothy K Cooper, Gregory Michael Holmes
Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal-level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial hypotension. Gastrointestinal (GI) tissues are critically dependent upon adequate blood flow and even brief periods of visceral hypoxia triggers GI dysmotility. The aim of this study was to test the hypothesis that T3-SCI induces visceral hypoperfusion, diminished postprandial vascular reflexes and concomitant visceral inflammation...
November 9, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27829729/bilateral-tka-for-charcot-arthropathy-associated-with-multiple-levels-of-spinal-canal-stenoses-a-case-report-and-review-of-literature
#10
Seiju Hayashi, Tomonari Okada, Keiji Horita
We report a case of an 84-year-old male with multiple levels of canal stenoses who are diagnosed as Charcot arthropathy of bilateral knees. Although he did not feel any pain, recurrence of joint fluid collection and severe instability prevented him from standing and walking. Deficit in superficial sensation and bathyesthesia below the level of Th10, and tendon reflexes of extremities were seen. Romberg test was positive. Laboratory data showed no abnormal findings. We performed bilateral TKA based on the diagnosis of Charcot arthropathy...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27817904/increased-spinal-pain-sensitization-in-major-depressive-disorder-a-pilot-study
#11
Andràs Tikàsz, Valérie Tourjman, Philippe Chalaye, Serge Marchand, Stéphane Potvin
Although patients suffering from major depressive disorder (MDD) often complain from painful symptoms, the relationship between experimental pain processes and depression has yet to be clearly characterized. Only recently have studies employing temporal summation (TS) paradigms offered preliminary insight into the co-occurrence of pain and depression. This study sets out to evaluate the contribution of spinal and supraspinal processes in pain sensitization in MDD using a TS paradigm. Thirteen volunteers with no psychiatric disorders (controls) and fourteen MDD subjects were included in the analysis...
October 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27817132/inhibitory-effect-of-estrogen-receptor-beta-on-p2x3-receptors-during-inflammation-in-rats
#12
Qian Jiang, Wen-Xin Li, Jia-Run Sun, Tian-Tian Zhu, Juan Fan, Li-Hua Yu, Geoffrey Burnstock, Hua Yang, Bei Ma
Estrogen receptor beta (ERβ) has been shown to play a therapeutic role in inflammatory bowel disease (IBD). However, the mechanism underlying how ERβ exerts therapeutic effects and its relationship with P2X3 receptors (P2X3R) in rats with inflammation is not known. In our study, animal behavior tests, visceromotor reflex recording, and Western blotting were used to determine whether the therapeutic effect of ERβ in rats with inflammation was related with P2X3R. In complete Freund adjuvant (CFA)-induced chronic inflammation in rats, paw withdrawal threshold was significantly decreased which were then reversed by systemic injection of ERβ agonists, DPN or ERB-041...
November 5, 2016: Purinergic Signalling
https://www.readbyqxmd.com/read/27814850/t4-syndrome-a-distinct-theoretical-concept-or-elusive-clinical-entity-a-case-report
#13
Patricia Miyuki Hirai, Oliver P Thomson
T4 syndrome has existed as a clinical concept for more than three decades and it has been identified as a source of upper extremity (UE) symptoms. This case report explores the clinical reasoning in the diagnoses and management of a patient with symptoms consistent with T4-type syndrome and critically discusses the concept of T4 syndrome using recent research to help explain the clinical presentation. Manual therapy treatment focused on stimulation of the sympathetic ganglia, decreasing local upper thoracic pain and UE referral pattern noted during passive examination...
October 2016: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/27813141/renal-deterioration-after-spinal-cord-injury-is-associated-with-length-of-detrusor-contractions-during-cystometry-a-study-with-a-median-of-41-years-follow-up
#14
Marlene Elmelund, Niels Klarskov, Per Bagi, Peter S Oturai, Fin Biering-Sørensen
AIMS: To investigate which urodynamic parameters are associated with renal deterioration over a median of 41 years follow-up after traumatic spinal cord injury. METHODS: Medical records of patients with a traumatic spinal cord injury sustained 1944-1975 were reviewed from time of injury until 2012. Patients who attended regular renography and/or renal clearance examinations and had minimum one cystometry and pressure-flow study were included. Renal deterioration was diagnosed as split renal function ≤30% in one kidney or relative glomerular filtration rate ≤51% of expected according to age and gender...
November 4, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27804131/identification-of-the-sexually-dimorphic-gastrin-releasing-peptide-system-in-the-lumbosacral-spinal-cord-that-controls-male-reproductive-function-in-the-mouse-and-asian-house-musk-shrew-suncus-murinus
#15
Kei Tamura, Yasuhisa Kobayashi, Asuka Hirooka, Keiko Takanami, Takumi Oti, Takamichi Jogahara, Sen-Ichi Oda, Tatsuya Sakamoto, Hirotaka Sakamoto
Several regions of the brain and spinal cord control male reproductive function. We previously demonstrated that the gastrin-releasing peptide (GRP) system, located in the lumbosacral spinal cord of rats, controls spinal centers to promote penile reflexes during male copulatory behavior. However, little information exists on the male-specific spinal GRP system in animals other than rats. The objective of this study was to examine the functional generality of the spinal GRP system in mammals using the Asian house musk shrew (Suncus murinus; suncus named as the laboratory strain), a specialized placental mammal model...
November 2, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27798354/low-frequency-stimulation-of-group-iii-and-iv-hind-limb-afferents-evokes-reflex-pressor-responses-in-decerebrate-rats
#16
Jonathan E Harms, Steven W Copp, Marc P Kaufman
Contraction of freely perfused hind limb muscles in decerebrate rats evokes the exercise pressor reflex, resulting in sympathetic activation and increased blood pressure. This reflex is propagated along mechanically sensitive group III and metabolically sensitive group IV afferent nerve fibers. Recent research by our laboratory has focused on the exaggeration of the exercise pressor reflex in decerebrate rats with simulated peripheral artery disease, which was induced by ligating the femoral artery for 72 h before the start of the experiment...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27798137/spike-timing-dependent-plasticity-in-the-long-latency-stretch-reflex-following-paired-stimulation-from-a-wearable-electronic-device
#17
K M Riashad Foysal, Felipe de Carvalho, Stuart N Baker
: The long-latency stretch reflex (LLSR) in human elbow muscles probably depends on multiple pathways; one possible contributor is the reticulospinal tract. Here we attempted to induce plastic changes in the LLSR by pairing noninvasive stimuli that are known to activate reticulospinal pathways, at timings predicted to cause spike timing-dependent plasticity in the brainstem. In healthy human subjects, reflex responses in flexor muscles were recorded following extension perturbations at the elbow...
October 19, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27792117/use-of-central-motor-conduction-time-and-spinal-cord-evoked-potentials-in-the-electrophysiological-assessment-of-compressive-cervical-myelopathy
#18
Kazuhiro Fujimoto, Tsukasa Kanchiku, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Norihiro Nishida, Toshihiko Taguchi
STUDY DESIGN: Retrospective study. OBJECTIVE: This study investigated the pathophysiology of compressive cervical myelopathy (CCM) with prolonged central motor conduction time (CMCT) in the upper limbs (UL) rather than lower limbs (LL) and prolonged CMCT at the thoracic level (TL). SUMMARY OF BACKGROUND DATA: Earlier reports indicated the usefulness of CMCT to assess preoperative CCM severity. However little information exists on patients with prolonged CMCT-UL rather than CMCT-LL and prolonged CMCT-TL...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27788509/experimental-electrophysiological-and-pressure-responses-of-urinary-bladder-detrusor-to-lumbar-to-sacral-nerve-rerouting-an-animal-study-with-negative-results
#19
Pavel Zerhau, Zdeněk Mackerle, Matej Husár, Daniela Sochůrková, Eva Brichtová, Eduard Gopfert, Martin Faldyna, Martin Kubát, Ladislav Plánka
: Background/Aims/Objectives: To verify the transfer of evoked potentials through anastomosis of an experimentally created micturition reflex arc and to detect said potentials directly on the detrusor and sphincter of rabbit urinary bladder. METHODS: During 2013-2015, 17 rabbits were operated upon and measurement followed during reoperation 3-16 months later. Suitable ventral spinal roots were electrophysiologically detected following laminectomy, and a somatic-central nervous system-autonomic micturition reflex arc was created...
2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27783854/neurocardiology-structure-based-function
#20
Jeffrey L Ardell, John Andrew Armour
Cardiac control is mediated via a series of reflex control networks involving somata in the (i) intrinsic cardiac ganglia (heart), (ii) intrathoracic extracardiac ganglia (stellate, middle cervical), (iii) superior cervical ganglia, (iv) spinal cord, (v) brainstem, and (vi) higher centers. Each of these processing centers contains afferent, efferent, and local circuit neurons, which interact locally and in an interdependent fashion with the other levels to coordinate regional cardiac electrical and mechanical indices on a beat-to-beat basis...
September 15, 2016: Comprehensive Physiology
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