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https://www.readbyqxmd.com/read/28719042/serotonergic-paraneurons-in-the-female-mouse-urethral-epithelium-and-their-potential-role-in-peripheral-sensory-information-processing
#1
F Aura Kullmann, Huiyi H Chang, Christian Gauthier, Bronagh M McDonnell, Jih-Chao Yeh, Dennis R Clayton, Anthony J Kanai, William C de Groat, Gerard L Apodaca, Lori A Birder
AIM: The mechanisms underlying detection and transmission of sensory signals arising from visceral organs, such as the urethra, are poorly understood. Recently, specialized ACh-expressing cells embedded in the urethral epithelium have been proposed as chemosensory sentinels for detection of bacterial infection. Here we examined the morphology and potential role in sensory signaling of a different class of specialized cells that express serotonin (5-HT), termed paraneurons. METHODS: Urethrae, dorsal root ganglia neurons and spinal cords were isolated from adult female mice and used for immunohistochemistry and calcium imaging...
July 18, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28717781/spinal-cord-infarction-mimicking-ischemic-heart-disease
#2
Dae Won Lee, Yoon Hee Choi
Spinal cord infarction is a rare condition and is easily misdiagnosed owing to its initial non-specific manifestation. We report a case of a 77-year-old man who presented with chest pain and upper back pain initially, and was misdiagnosed with a myocardial infarction. Four hours after admission, he complained of numbness in his entire left leg below the knee, with rapid deterioration of neurological symptoms. After 9 hours, loss of sensation progressed up to the T4 dermatome, strength of both lower extremities deteriorated to grade 0, and decrease in anal tone and deep tendon reflex was observed...
June 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/28716590/lumbar-muscle-inflammation-alters-spinally-mediated-locomotor-recovery-induced-by-training-in-a-mouse-model-of-complete-spinal-cord-injury
#3
Renaud Jeffrey-Gauthier, Mathieu Piché, Hugues Leblond
Locomotor networks after spinal cord injury (SCI) are shaped by training-activated proprioceptive and cutaneous inputs. Nociception from injured tissues may alter these changes but has largely been overlooked. The objective of the present study was to ascertain whether lumbar muscle inflammation hinders locomotion recovery in a mouse model of complete SCI. Lower limb kinematics during treadmill training was assessed before and after complete SCI at T8 (2, 7, 14, 21 and 28 days post-injury). Locomotor recovery was compared in 4 groups of CD1 mice: control spinal mice; spinal mice with daily locomotor training; spinal mice with lumbar muscle inflammation (Complete Freund's Adjuvant (CFA) injection); and spinal mice with locomotor training and CFA...
July 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28715353/learned-expectations-and-uncertainty-facilitate-pain-during-classical-conditioning
#4
Veronique A Taylor, Luke Chang, Pierre Rainville, Mathieu Roy
Pain spontaneously activates adaptive and dynamic learning processes affecting the anticipation of, and the responses to, future pain. Computational models of associative learning effectively capture the production and ongoing changes in conditioned anticipatory responses (eg, skin conductance response), but the impact of this dynamic process on unconditional pain responses remains poorly understood. Here, we investigated the dynamic modulation of pain and the nociceptive flexion reflex by fear learning in healthy human adult participants undergoing a classical conditioning procedure involving an acquisition, reversal and extinction phase...
August 2017: Pain
https://www.readbyqxmd.com/read/28714784/the-management-of-paediatric-neurogenic-bladder-an-approach-in-a-resource-poor-setting
#5
Patrick Opoku Manu Maison, John Lazarus
BACKGROUND: If untreated, paediatric neurogenic bladder can cause renal failure and urinary incontinence. It is usually caused by neural tube defects such as myelomeningocele. Children with a neurogenic bladder should be monitored from birth and management should aim to preserve renal function and achieve social continence. This article outlines the management options appropriate for these children in resource-poor settings. ASSESSMENT: In most low- and middle-income countries, a general lack of awareness of the neurological effects on the urinary tract results in late presentation, usually with urological complications even when spina bifida is diagnosed early...
July 17, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28713038/assessment-of-sexual-function-in-women-with-neurological-disorders-a-review
#6
REVIEW
Frédérique Courtois, Marina Gérard, Kathleen Charvier, David B Vodušek, Gérard Amarenco
BACKGROUND: Although the rehabilitation of sexual function has been identified as a top priority among women presenting neurological conditions, sexual function is rarely assessed in this clinical group. OBJECTIVES: To review published assessment tools of sexual dysfunction in women with neurological conditions including multiple sclerosis (MS), spinal cord injury (SCI), Parkinson disease, stroke, traumatic brain injury. METHODS: A systematic literature review was conducted with Medline via PubMed, PubMed Central, and Medline databases...
July 13, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28706615/novel-effects-of-traditional-wooden-toothbrush-on-bowel-motility-symptoms-in-spinal-cord-injury-patients-findings-from-a-pilot-quasi-experimental-study
#7
Ebrahim Esfandiari, Awat Feizi, Zahra Heidari, Seyed Reza Tabibian, Pooria Shaabani, Bijan Iraj, Payman Adibi, Amrollah Ebrahimi Varzaneh
BACKGROUND: The aim of this study was to investigate the therapeutic effect of traditional wooden toothbrush usage on most severe constipation, which usually occurs in spinal cord injury (SCI) patients. METHODS: In a quasi-experimental study, 61 SCI patients were selected who had injuries in different spinal levels (cervical, thoracic, and lumbar), and severe constipation from one defection in a few days to 3 weeks. They were recommended to use traditional wooden toothbrush for 5 min twice a day, after breakfast and dinner, over a 6 weeks period...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28705167/inhibition-of-parkinsonian-tremor-with-cutaneous-afferent-evoked-by-transcutaneous-electrical-nerve-stimulation
#8
Man-Zhao Hao, Shao-Qin Xu, Zi-Xiang Hu, Fu-Liang Xu, Chuan-Xin M Niu, Qin Xiao, Ning Lan
BACKGROUND: Recent study suggests that tremor signals are transmitted by way of multi-synaptic corticospinal pathway. Neurophysiological studies have also demonstrated that cutaneous afferents exert potent inhibition to descending motor commands by way of spinal interneurons. We hypothesize in this study that cutaneous afferents could also affect the transmission of tremor signals, thus, inhibit tremor in patients with PD. METHODS: We tested this hypothesis by activating cutaneous afferents in the dorsal hand skin innervated by superficial radial nerve using transcutaneous electrical nerve stimulation (TENS)...
July 14, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28695904/neuropathic-pain-and-spasticity-intricate-consequences-of-spinal-cord-injury
#9
REVIEW
N B Finnerup
STUDY DESIGN: The 2016 International Spinal Cord Society Sir Ludwig Guttmann Lecture. OBJECTIVES: The aim of this review is to identify different symptoms and signs of neuropathic pain and spasticity after spinal cord injury (SCI) and to present different methods of assessing them. The objective is to discuss how a careful characterization of different symptoms and signs, and a better translation of preclinical findings may improve our understanding of the complex and entangled mechanisms of neuropathic pain and spasticity...
July 11, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28680270/parents-assessments-of-disability-in-their-children-using-world-health-organization-international-classification-of-functioning-disability-and-health-child-and-youth-version-joined-body-functions-and-activity-codes-related-to-everyday-life
#10
Niels Ove Illum, Kim Oren Gradel
AIM: To help parents assess disability in their own children using World Health Organization (WHO) International Classification of Functioning, Disability and Health, Child and Youth Version (ICF-CY) code qualifier scoring and to assess the validity and reliability of the data sets obtained. METHOD: Parents of 162 children with spina bifida, spinal muscular atrophy, muscular disorders, cerebral palsy, visual impairment, hearing impairment, mental disability, or disability following brain tumours performed scoring for 26 body functions qualifiers (b codes) and activities and participation qualifiers (d codes)...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28673064/effects-of-acute-sacral-neuromodulation-at-different-frequencies-on-bladder-overactivity-in-pigs
#11
Xing Li, Limin Liao, Guoqing Chen, Zhaoxia Wang, Han Deng
PURPOSE: We investigated the effects of different stimulation frequencies on the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs. METHODS: Implant-driven stimulators were used to stimulate the S3 spinal nerve in 13 pigs. Cystometry was performed by infusing normal saline (NS) or acetic acid (AA). SNM (pulse width, 210 µsec) at frequencies ranging from 5 to 50 Hz was conducted at the intensity threshold at which observable perianal and/or tail movement was induced...
June 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28666000/dynamic-wheelchair-seating-positions-impact-cardiovascular-function-after-spinal-cord-injury
#12
Jessica A Inskip, Henrike Rianne J C Ravensbergen, Inderjeet S Sahota, Christine Zawadzki, Lowell T McPhail, Jaimie F Borisoff, Victoria E Claydon
BACKGROUND: Innovative wheelchairs allow individuals to change position easily for comfort and social situations. While these wheelchairs are beneficial in multiple ways, the effects of position changes on blood pressure might exacerbate hypotension and cerebral hypoperfusion, particularly in those with spinal cord injury (SCI) who can have injury to autonomic nerves that regulate cardiovascular control. Conversely, cardiovascular benefits may be obtained with lowered seating. Here we investigate the effect of moderate changes in wheelchair position on orthostatic cardiovascular and cerebrovascular reflex control...
2017: PloS One
https://www.readbyqxmd.com/read/28665378/-the-application-of-general-magnetic-therapy-for-the-rehabilitation-of-the-patients-following-the-surgical-treatment-of-herniated-intervertebral-discs
#13
D D Voronina, A G Kulikov, I A Luppova, O V Yarustovskaya
AIM: The objective of the present work was to rehabilitate more efficiently the patients who had undergone the surgical treatment for herniated discs in the lumbosacral spine by applying general magnetic therapy during the combined treatment. MATERIAL AND METHODS: A total of 73 patients underwent the medical examination and treatment. The patients matched for age and sex presenting with similar clinical symptoms were divided into two groups. All of them received initial therapy that included medication, therapeutic physical exercises, and aquatic therapy...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28663632/obturator-nerve-block-in-transurethral-resection-of-bladder-tumor-a-comparison-of-ultrasound-guided-technique-versus-ultrasound-with-nerve-stimulation-technique
#14
Nida Farooq Shah, Khalid Parvez Sofi, Showkat Hussain Nengroo
BACKGROUND: Obturator nerve (ON) stimulation during transurethral resection of lateral and posterolateral bladder wall tumor under spinal anesthesia may lead to obturator reflex, adductor contraction, and leg jerking with complications such as bleeding, bladder perforation, or incomplete tumor resection. Our study was carried out to obtain successful block of ON using ultrasound (US)-guided technique with or without nerve stimulation in patients undergoing transurethral resection of bladder tumor (TURBT) under spinal anesthesia...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28663095/meta-analysis-of-stem-cell-transplantation-for-reflex-hypersensitivity-after-spinal-cord-injury
#15
Xuemei Chen, Bohan Xue, Yuping Li, Chunhua Song, Peijun Jia, Xiuhua Ren, Weidong Zang, Jian Wang
Stem cells have been used in novel therapeutic strategies for spinal cord injury (SCI), but the effect of stem cell transplantation on neuropathic pain after SCI is unclear. The current meta-analysis evaluates the effects of stem cell transplantation on neuropathic pain after SCI. We first conducted online searches of PubMed, Web of Science, China Academic Journals Full-text Database, and Wanfang Data for randomized controlled trials that compared stem cell transplantation and vehicle treatments in rodent models of neuropathic pain after SCI...
June 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28662631/a-case-of-neuropsychiatric-lupus-erythematosus-characterized-by-the-owl-s-eye-sign-a-case-report
#16
Bolin Hu, Pengcheng Wu, Yibiao Zhou, Yan Peng, Xiaoping Tang, Weijiang Ding, Ming Zhang, Xueliang Qi
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder characterized by multiple affected systems. More than half of SLE patients will suffer from neuropsychiatric lupus erythematosus (NPSLE) during the course of their disease. Although nearly half of the NPSLE patients have normal MRI manifestations, the abnormalities found in the remainder can be located anywhere in the brain, and especially in the subcortical white matter of the frontal and temporal lobe...
June 29, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28662201/neural-effects-of-muscle-stretching-on-the-spinal-reflexes-in-multiple-lower-limb-muscles
#17
Yohei Masugi, Hiroki Obata, Daisuke Inoue, Noritaka Kawashima, Kimitaka Nakazawa
While previous studies have shown that muscle stretching suppresses monosynaptic spinal reflex excitability in stretched muscles, its effects on non-stretched muscles is still largely unknown. The purpose of this study was to examine the effects of muscle stretching on monosynaptic spinal reflex in non-stretched muscles. Ten healthy male subjects participated in this study. Muscle stretching of the right triceps surae muscle was performed using a motor torque device for 1 minute. Three different dorsiflexion torques (at approximately 5, 10, and 15 Nm) were applied during muscle stretching...
2017: PloS One
https://www.readbyqxmd.com/read/28652118/analysis-of-patients-with-myelopathy-due-to-benign-intradural-spinal-tumors-with-concomitant-lumbar-degenerative-diseases-misdiagnosed-and-erroneously-treated-with-lumbar-surgery
#18
Kang Lu, Hao-Kuang Wang, Po-Chou Liliang, Chih-Hui Yang, Cheng-Yo Yen, Yu-Duan Tsai, Po-Yuan Chen, Cien-Leong Chye, Kuo-Wei Wang, Cheng-Loong Liang, Han-Jung Chen
BACKGROUND AND OBJECTIVE: When a cervical or thoracic benign intradural spinal tumor (BIST) coexists with lumbar degenerative diseases (LDD), diagnosis may become difficult. Symptoms of BIST-myelopathy may be mistaken as related to LDD. Worse, an unnecessary lumbar surgery could be performed. This study was conducted to analyze cases in which an erroneous lumbar surgery was undertaken in the wake of failure to identify BIST-associated myelopathy. METHODS: Cases were found in a hospital database...
June 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28638331/monosynaptic-stretch-reflex-fails-to-explain-the-initial-postural-response-to-sudden-lateral-perturbations
#19
Andreas Mühlbeier, Christian Puta, Kim J Boström, Heiko Wagner
Postural reflexes are essential for locomotion and postural stability, and may play an important role in the etiology of chronic back pain. It has recently been theoretically predicted, and with the help of unilateral perturbations of the trunk experimentally confirmed that the sensorimotor control must lower the reflex amplitude for increasing reflex delays to maintain spinal stability. The underlying neuromuscular mechanism for the compensation of postural perturbations, however, is not yet fully understood...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28629562/3t-mr-defecography-a-feasibility-study-in-sensorimotor-complete-spinal-cord-injured-patients-with-neurogenic-bowel-dysfunction
#20
Cornelia Putz, Celine D Alt, Cornelia Hensel, Björn Wagner, Simone Gantz, Hans-Jürgen Gerner, Norbert Weidner, Lars Grenacher
INTRODUCTION: To investigate whether MR-defecography can be employed in sensorimotor complete spinal cord injury (SCI) subjects as a potential diagnostic tool to detect defecational disorders associated with neurogenic bowel dysfunction (NBD) using standard parameters for obstructed defecation. MATERIAL AND METHODS: In a prospective single centre clinical trial, we developed MR-defecography in traumatic sensorimotor complete paraplegic SCI patients with upper motoneuron type injury (neurological level of injury T1 to T10) using a conventional 3T scanner...
June 2017: European Journal of Radiology
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