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https://www.readbyqxmd.com/read/29902481/precision-medicine-and-drug-development-in-alzheimer-s-disease-the-importance-of-sexual-dimorphism-and-patient-stratification
#1
REVIEW
Harald Hampel, Andrea Vergallo, Filippo Sean Giorgi, Seung Hyun Kim, Herman Depypere, Manuela Graziani, Amira Saidi, Robert Nisticò, Simone Lista
Neurodegenerative diseases (ND) are among the leading causes of disability and mortality. Considerable sex differences exist in the occurrence of the various manifestations leading to cognitive decline. Alzheimer's disease (AD) exhibits substantial sexual dimorphisms and disproportionately affects women.Women have a higher life expectancy compared to men and, consequently, have more lifespan to develop AD. The emerging precision medicine and pharmacology concepts - taking into account the individual genetic and biological variability relevant for disease risk, prevention, detection, diagnosis, and treatment - are expected to substantially enhance our knowledge and management of AD...
June 11, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29902162/youth-risk-behavior-surveillance-united-states-2017
#2
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29899521/ensuring-a-bright-present-and-future-for-sexual-medicine
#3
Yacov Reisman, Selcuk Sarikaya
No abstract text is available yet for this article.
June 13, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29898886/sexual-harassment-of-us-women-in-science-is-widespread-and-is-worst-in-medicine-report-says
#4
Janice Hopkins Tanne
No abstract text is available yet for this article.
June 13, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29896468/protocol-for-an-hiv-pre-exposure-prophylaxis-prep-population-level-intervention-study-in-victoria-australia-the-prepx-study
#5
Kathleen E Ryan, Anne Mak, Mark Stoove, Brian Price, Christopher K Fairley, Simon Ruth, Luxshimi Lal, Jason Asselin, Carol El-Hayek, Long Nguyen, Colin Batrouney, David Wilson, John Lockwood, Dean Murphy, Vincent J Cornelisse, Norman Roth, Jeff Willcox, Christina C Chang, Judy Armishaw, Ban K Tee, Matthew Penn, George Forgan-Smith, Christopher Williams, Jeff Montgomery, Kat Byron, Alison Coelho, Brent Allen, Jeremy Wiggins, Jenny Kelsall, Olga Vujovic, Michael West, Anna B Pierce, Daniel Gallant, Charlotte Bell, John B F de Wit, Jennifer F Hoy, Steve L Wesselingh, Robert M Grant, Edwina J Wright
Background: Pre-exposure prophylaxis (PrEP) is the use of HIV anti-retroviral therapy to prevent HIV transmission in people at high risk of HIV acquisition. PrEP is highly efficacious when taken either daily, or in an on-demand schedule. In Australia co-formulated tenofovir-emtricitabine is registered for daily use for PrEP, however, this co-formulation is not listed yet on the national subsidized medicines list. We describe a study protocol that aims to demonstrate if the provision of PrEP to up to 3800 individuals at risk of HIV in Victoria, Australia reduces HIV incidence locally by 25% generally and 30% among GBM...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29889310/the-effects-of-oxcarbazepine-levetiracetam-and-lamotrigine-on-semen-quality-sexual-function-and-sex-hormones-in-male-adults-with-epilepsy
#6
Dongmei Wu, Lang Chen, Fayuan Ji, Yang Si, Hongbin Sun
OBJECTIVE: To investigate the effects of antiepileptic drugs (AEDs; oxcarbazepine [OXC], levetiracetam [LEV], and lamotrigine [LTG]) on semen quality, sexual function, and sex hormones in male adults with epilepsy. METHODS: Individual treatment with OXC, LEV, or LTG was randomly assigned to 38 newly diagnosed male adult patients with epilepsy. Semen quality and sex hormones were measured before treatment and 6 months after taking the medicine. A questionnaire was administered using the International Index of Erectile Function Scale-5 and the Premature Ejaculation Diagnostic Tool Self-Assessment Scale to evaluate sexual function, followed by an analysis of the comparison between the treated patients and healthy volunteers (healthy controls) as well as the changes and differences between the patients themselves before and after treatment...
June 11, 2018: Epilepsia
https://www.readbyqxmd.com/read/29884445/sexual-health-care-practitioners-evaluation-of-men-who-have-sex-with-men
#7
Michael Saheb Kashaf, Peter R Butler, Billy H Cordon-Galiano, Amin S Herati
BACKGROUND: The Institute of Medicine Report and Department of Health and Human Services Healthy People 2020 Initiative have called for steps to address health disparities facing sexual minorities. AIM: We sought to characterize the practice patterns of sexual health specialists as they relate to men who have sex with men (MSM). METHODS: Surveys were electronically mailed to 696 members of the Sexual Medicine Society of North America (SMSNA)...
June 5, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29881706/a-systematic-review-and-meta-analysis-of-clinical-trials-on-saffron-crocus-sativus-effectiveness-and-safety-on-erectile-dysfunction-and-semen-parameters
#8
REVIEW
Nahid Maleki-Saghooni, Khadijeh Mirzaeii, Hossein Hosseinzadeh, Ramin Sadeghi, Morvarid Irani
Objective: We performed this systematic review and meta-analysis study to determine saffron ( Crocus sativus ) effectiveness and safety in male infertility problems. Materials and Methods: The databases PubMed, Scopus, Cochrane, Google Scholar, SID, IranMedex and Magiran until July 2016 and reference section of relevant articles, were searched to find both English and Persian clinical trials on male infertility issues that used saffron as medical treatment. Also, the quality of these trials was evaluated by Oxford Center for Evidence Based Medicine checklist...
May 2018: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29881519/effects-of-a-food-product-based-on-daucus-carota-and-education-based-on-traditional-persian-medicine-on-female-sexual-dysfunction-a-randomized-clinical-trial
#9
Tahereh Molkara, Farideh Akhlaghi, Mohammad Arash Ramezani, Roshanak Salari, Veda Vakili, Mohammad Kamalinejad, Mohammad Reza Fayyazi Bordbar, Ahmad Ghorbani, Malihe Motavasselian
Background: Globally, female sexual dysfunction is a serious concern based on negative family and social consequences, high side effects of medications and lack of effective treatment. Thus, the evaluation of treatment approach for this problem is an important priority for healthcare systems. Sexual life and its related disorders are considered the main aspects of a healthy lifestyle in traditional Persian medicine (TPM). Objective: The present study aimed to determine and compare the effects of food products containing Daucus carota, TPM-based training program, and a combination of these two interventions on the improvement of female sexual dysfunction...
April 2018: Electronic Physician
https://www.readbyqxmd.com/read/29881260/knowledge-attitude-and-practice-on-and-willingness-to-pay-for-human-papillomavirus-vaccine-a-cross-sectional-study-in-hanoi-vietnam
#10
Bach Xuan Tran, Phung Tat Quoc Than, Tien Thuy Ngoc Doan, Huong Lan Thi Nguyen, Hue Thi Mai, Trang Huyen Thi Nguyen, Huong Thi Le, Carl A Latkin, Melvyn Wb Zhang, Roger Cm Ho
Background: Despite its effectiveness in preventing human papillomavirus (HPV) infection, the rate of uptake of the HPV vaccine is low in Vietnam. This study aimed to investigate barriers related to knowledge-attitude-practice (KAP) about the HPV vaccine and willingness to pay (WTP) for the vaccine among those using services in an urban vaccination clinic in Hanoi, Vietnam. Materials and methods: A cross-sectional study was conducted in a vaccination clinic of the Institute for Preventive Medicine and Public Health in Hanoi, Vietnam, from March to April 2016...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29880262/clinical-pearls-in-sexual-medicine
#11
REVIEW
Jordan Rullo, Scott C Litin, John B Bundrick
No abstract text is available yet for this article.
June 4, 2018: Disease-a-month: DM
https://www.readbyqxmd.com/read/29871673/-test-n-treat-tnt-rapid-testing-and-same-day-on-site-treatment-to-reduce-rates-of-chlamydia-in-sexually-active-further-education-college-students-study-protocol-for-a-cluster-randomised-feasibility-trial
#12
Sarah Kerry-Barnard, Charlotte Fleming, Fiona Reid, Rachel Phillips, Vari M Drennan, Elisabeth J Adams, Wendy Majewska, Anjella Balendra, Emma Harding-Esch, Emma Cousins, S Tariq Sadiq, Pippa Oakeshott
BACKGROUND: Sexually active young people attending London further education (FE) colleges have high rates of chlamydia, but screening rates are low. We will conduct a cluster randomised feasibility trial of frequent, rapid, on-site chlamydia testing and same-day treatment (Test and Treat (TnT)) in six FE colleges (with parallel qualitative and economic assessments) to assess the feasibility of conducting a future trial to investigate if TnT reduces chlamydia rates. METHODS: We will recruit 80 sexually active students aged 16-24 years from public areas at each of six colleges...
June 5, 2018: Trials
https://www.readbyqxmd.com/read/29866492/-coital-incontinence
#13
M Moutounaïck, G Miget, M Teng, F Kervinio, C Chesnel, A Charlanes, F Le Breton, G Amarenco
INTRODUCTION: Urinary incontinence may seriously impact quality of life, self-image and subsequently the sexual life. Beside this fact, urinary leakage can specifically occur during sexual intercourse, formally named coital incontinence, and thus lead to specific alteration of the sexual life. AIM: To analyse the prevalence, pathophysiological mechanisms and possible therapeutic options for coital urinary incontinence. METHODS: Related terms to urinary incontinence and sexual dysfunction were search on PubMed database...
June 1, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29861363/is-male-sexual-abuse-a-topic-for-sexual-medicine
#14
Eusebio Rubio-Aurioles
No abstract text is available yet for this article.
May 31, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29851923/streptococcus-constellatus-tubo-ovarian-abscess-in-a-non-sexually-active-adolescent-female
#15
David Mills, Bazak Sharon, Kari Schneider
Tubo-ovarian abscess (TOA) in non-sexually active female adolescents is a rare presentation to the pediatric emergency department. In the following case, bilateral TOA secondary to Streptococcus constellatus was diagnosed in a 13-year-old virginal female. The patient was seen 4 months before presentation for interventional radiology-guided drainage and antibiotic treatment for an intra-abdominal abscess due to suspected appendiceal rupture. Exploratory laparotomy on the most recent presentation demonstrated an appendix with inflammation and serositis on pathology report, a concern for chronic appendicitis with microperforation and subsequent bacterial translocation of the bilateral ovaries...
June 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29843860/assessing-the-value-of-western-cape-provincial-government-health-administrative-data-and-electronic-pharmacy-records-in-ascertaining-medicine-use-during-pregnancy
#16
U Mehta, A Heekes, E Kalk, A Boulle
BACKGROUND: In African settings, where there is a high disease burden, there is a need to improve the science of documenting and analysing accurate information regarding medicine exposures in women immediately before and during pregnancy to assess the extent of use and safety in pregnant women and their unborn children. OBJECTIVES: To compare evidence of medicine use during pregnancy, as documented in paper-based clinical records (maternity case records (MCRs)) against electronic health information resources (Provincial Health Data Centre (PHDC)) and assess the level of concordance between the two as part of baseline investigations before piloting a provincial pregnancy exposure registry and birth defect surveillance system...
April 25, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29804275/the-effect-of-the-medico-legal-evaluation-on-asylum-seekers-in-the-metropolitan-city-of-milan-italy-a-pilot-study
#17
L Franceschetti, F Magli, V G Merelli, E A Muccino, A Gentilomo, F Agazzi, D M Gibelli, M Gambarana, D De Angelis, A Kustermann, C Cattaneo
In the present-day situation, the clinical forensic documentation of an asylum seeker's narrative and his or her examination, together with the physical and psychological findings, may have very important effects on the outcome of the request for political asylum. Since 2012, the Municipality of Milan, the University Institute of Legal Medicine, and other institutions have assembled a team with the task of examining vulnerable asylum seekers and preparing a medical report for the Territorial Commission for International Protection (Prefecture, Ministry of Interiors), who will assess the application...
May 26, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29803350/penile-elastography-current-and-future-applications-in-sexual-medicine
#18
Felipe Carneiro, Eduardo P Miranda
No abstract text is available yet for this article.
June 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29801952/expectations-and-boundaries-for-big-data-approaches-in-social-medicine
#19
Chloé Dimeglio, Michelle Kelly-Irving, Thierry Lang, Cyrille Delpierre
It seems no longer possible to produce knowledge, even biological knowledge regardless of social, cultural and economic environments in which they were observed. Therefore never the term "social medicine" or more generally "social biology" has appeared more appropriate. This way of linking the social and the biological exceeds the sole social medicine by involving also other medical disciplines. As such, forensics, whose an important activity is represented by clinical forensics in charge of types of violence (physical, psychological, sexual, abuse) and persons held in custody could see its practice heavily modified through the use of various data describing both the clinical situation of patients but also their context of life...
July 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29801945/a-data-model-for-clinical-legal-medicine-practice-and-the-development-of-a-dedicated-software-for-both-practitioners-and-researchers
#20
Catherine Dang, Thomas Phuong, Mahmoud Beddag, Anabel Vega, Céline Denis
OBJECTIVE: To present a data model for clinical legal medicine and the software based on that data model for both practitioners and researchers. The main functionalities of the presented software are computer-assisted production of medical certificates and data capture, storage and retrieval. METHODS: The data model and the software were jointly developed by the department of forensic medicine of the Jean Verdier Hospital (Bondy, France) and an bioinformatics laboratory (LIMICS, Paris universities 6-13) between November 2015 and May 2016...
July 2018: Journal of Forensic and Legal Medicine
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