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https://www.readbyqxmd.com/read/29140489/including-the-patient-voice-in-patient-centered-outcomes-research-in-integrative-oncology
#1
Jodi MacLeod, Edward Wolff, Alice McAllister, Jun J Mao, Sheila N Garland
The objective of this paper is to describe our experience as patient advisors as we work on a Patient-Centered Outcomes Research Institute-funded project, CHoosing Options for Insomnia in Cancer Effectively (CHOICE). The CHOICE Study is a comparative effectiveness trial comparing acupuncture with cognitive behavioral therapy for insomnia in cancer survivors. We describe the composition of the patient advisory panel, the patient engagement process, and our contributions throughout the study, and we highlight some of our successes so far...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29138897/correction-to-imported-falciparum-malaria-in-adults-host-and-parasite-related-factors-associated-with-severity-the-french-prospective-multicenter-palurea-cohort-study
#2
Fabrice Bruneel, Florence Tubach, Jean-Paul Mira, Sandrine Houze, Sebastien Gibot, Marie-Genevieve Huisse, Bruno Megarbane, Christophe Choquet, Philippe Corne, Eric Peytel, Daniel Villers, Christophe Camus, Olivier Bouchaud, Eric Caumes, Pierre-Marie Girard, Fabrice Simon, Antoine Kalloumeh, Carine Roy, Remy Durand, Jacques Le Bras, Sophie Matheron, Michel Wolff
The members of the Palurea Study Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for this error and is pleased to list the members of the group here.
November 14, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29137387/infrequently-expressed-mirnas-influence-survival-after-diagnosis-with-colorectal-cancer
#3
Martha L Slattery, Andrew J Pellatt, Frances Y Lee, Jennifer S Herrick, Wade S Samowitz, John R Stevens, Roger K Wolff, Lila E Mullany
Half of miRNAs expressed in colorectal tissue are expressed < 50% of the population. Many infrequently expressed miRNAs have low levels of expression. We hypothesize that less frequently expressed miRNAs, when expressed at higher levels, influence both disease stage and survival after diagnosis with colorectal cancer (CRC); low levels of expression may be background noise. We examine 304 infrequently expressed miRNAs in 1893 population-based cases of CRC with paired carcinoma and normal mucosa miRNA profiles...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133494/multimorbidity-and-decision-making-preferences-among-older-adults
#4
Winnie C Chi, Jennifer Wolff, Raquel Greer, Sydney Dy
PURPOSE: Understanding individuals' preferences for participating in health care decisions is foundational to delivering person-centered care. We aimed to (1) explore preferences for health care decision making among older adults, and (2) identify multimorbidity profiles associated with preferring less active, ie, passive, participation among older US adults. METHOD: Ours was a cross-sectional, nationally representative study of 2,017 National Health and Aging Trends Study respondents...
November 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/29124990/yoga-a-laborious-way-to-well-being-patients-experiences-of-yoga-as-a-treatment-for-hypertension-in-primary-care
#5
Moa Wolff, Annika Brorsson, Patrik Midlöv, Kristina Sundquist, Eva Lena Strandberg
OBJECTIVE: The aim of the study was to describe patients' experience of yoga as a treatment for hypertension, as well as their experience of living with hypertension. DESIGN: Qualitative interview study Method and materials: In 2013-2014, in southern Sweden, patients with hypertension from three health care centres were invited to participate in a randomised controlled trial on yoga for hypertension. After completion of the study, eight women and five men (aged 35-79), who had practiced the yoga intervention, were interviewed about their experiences...
November 10, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29124788/need-for-multiscale-planning-for-conservation-of-urban-bats
#6
Travis Gallo, Elizabeth W Lehrer, Mason Fidino, R Julia Kilgour, Patrick J Wolff, Seth Magle
For over a century there have been continual efforts to incorporate nature into urban planning. These efforts - known as urban reconciliation- aim to manage and create habitats that support biodiversity within cities. Given that species select habitat at different spatial scales, understanding the scale at which urban species respond to their environment is critical to the success of urban reconciliation efforts. We assessed species-habitat relationships for common bat species at local (50-m), medium (500-m), and broad (1-km) spatial scales in the Chicago metropolitan area and predicted bat activity across the greater Chicago region...
November 10, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29122102/work-time-distribution-of-physicians-at-a-german-university-hospital
#7
Jan Wolff, Gerd Auber, Tobias Schober, Felix Schwär, Karl Hoffmann, Marc Metzger, Andrea Heinzmann, Marcus Krüger, Claus Normann, Gerald Gitsch, Norbert Südkamp, Thomas Reinhard, Mathias Berger
BACKGROUND: The effective utilization of staff resources is of decisive importance for the adequate, appropriate, and economical delivery of hospital services. The goal of this study was to determine the distribution of working time among doctors in a German university hospital-in particular, in terms of type of activities and time of day. METHODS: The distribution of working time was determined from 14-day samples taken in seven clinical departments of the Medical Center-University of Freiburg...
October 20, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29120606/management-of-respiratory-infections-with-use-of-procalcitonin-moving-toward-more-personalized-antibiotic-treatment-decisions
#8
Yannick Wirz, Angela Branche, Michel Wolff, Tobias Welte, Vandack Nobre, Konrad Reinhart, Ann R Falsey, Pierre Damas, Albertus Beishuizen, Rodrigo O Deliberato, Yahya Shehabi, Jens-Ulrik S Jensen, Beat Mueller, Philipp Schuetz
Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to antibiotic overuse in this population of patients. Addition of procalcitonin, a blood biomarker expressed by epithelial cells in response to bacterial infections, to the clinical assessment leads to a reduction in inappropriate antibiotic initiation. Procalcitonin also provides prognostic information about the resolution of illness, and significant decreases over time are a strong signal for the discontinuation of antibiotics...
November 9, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29119627/colorectal-cancer-susceptibility-loci-as-predictive-markers-of-rectal-cancer-prognosis-after-surgery
#9
Yue Hu, Jochen Gaedcke, Georg Emons, Tim Beissbarth, Marian Grade, Peter Jo, Meredith Yeager, Stephen J Chanock, Hendrik Wolff, Jordi Camps, B Michael Ghadimi, Thomas Ried
To understand the molecular mechanism of rectal cancer and develop markers for disease prognostication, we generated and explored a dataset from 243 rectal cancer patients by gene expression microarray analysis of cancer samples and matched controls, and SNP-arrays of germline DNA. We found that two of the loci most strongly linked with colorectal cancer (CRC) risk, 8q24 (upstream of MYC) and 18q21 (in the intron of SMAD7), as well as 20q13 (in the intron of LAMA5), are tightly associated with the prognosis of rectal cancer patients...
November 9, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29115093/a-case-of-multiple-cardiovascular-and-tracheal-anomalies-presented-with-wolff-parkinson-white-syndrome-in-a-middle-aged-adult
#10
Hyejin Shi, Sungmin Sohn, SungHo Wang, Sungrock Park, SangKi Lee, Song Yi Kim, Sun Young Jeong, Changhwan Kim
Congenital cardiovascular anomalies, such as dextrocardia, persistent left superior vena cava (SVC), and pulmonary artery (PA) sling, are rare disorders. These congenital anomalies can occur alone, or coincide with other congenital malformations. In the majority of cases, congenital anomalies are detected early in life by certain signs and symptoms. A 56-year-old man with no previous medical history was admitted due to recurrent wide QRS complex tachycardia with hemodynamic collapse. A chest radiograph showed dextrocardia...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29114609/dose-escalation-with-an-imrt-technique-in-15-to-28-fractions-is-better-tolerated-than-standard-doses-of-3dcrt-for-lapc
#11
Lauren E Colbert, Shalini Moningi, Awalpreet Chadha, Ahmed Amer, Yeonju Lee, Robert A Wolff, Gauri Varadhachary, Jason Fleming, Matthew Katz, Prajnan Das, Sunil Krishnan, Eugene J Koay, Peter Park, Christopher H Crane, Cullen M Taniguchi
Purpose: To review acute and late toxicities after chemoradiation for locally advanced pancreatic ductal adenocarcinoma in patients who were treated with escalated dose radiation (EDR). Methods and materials: Maximum Common Terminology Criteria for Adverse Events Version 4.0 acute toxicities (AT) during radiation and within 60 days after radiation were recorded for both acute gastrointestinal toxicity and overall toxicity (OT). Late toxicities were also recorded...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29111396/limitations-and-pitfalls-of-the-pedicle-screw-testing-monitoring-technique-an-in-vivo-and-in-vitro-study
#12
Julie Zyss, Isabelle Bernat, Stéphane Wolff, Guillaume Riouallon, Hugues Pascal-Moussellard
OBJECTIVES: Pedicle screw testing is a widely used technique in the field of neuromonitoring for spinal surgery. It was designed by Calancie et al. (1992) in order to detect pedicle breach, one of the major complications of pedicle screw fixation, which can lead to neurological impairment. However, numerous false negative and equivocal results led to its clinical relevance being questioned. We aimed to clarify these discrepancies and characterize electrical parameters underlying this technique...
October 27, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29110152/low-pten-levels-and-pik3ca-mutations-predict-resistance-to-neoadjuvant-lapatinib-and-trastuzumab-without-chemotherapy-in-patients-with-her2-over-expressing-breast-cancer
#13
Mothaffar F Rimawi, Carmine De Angelis, Alejandro Contreras, Fresia Pareja, Felipe C Geyer, Kathleen A Burke, Sabrina Herrera, Tao Wang, Ingrid A Mayer, Andres Forero, Rita Nanda, Matthew P Goetz, Jenny C Chang, Ian E Krop, Antonio C Wolff, Anne C Pavlick, Suzanne A W Fuqua, Carolina Gutierrez, Susan G Hilsenbeck, Marilyn M Li, Britta Weigelt, Jorge S Reis-Filho, C Kent Osborne, Rachel Schiff
PURPOSE: Aberrant activation of the PI3K pathway has been implicated in resistance to HER2-targeted therapy, but results of clinical trials are confounded by the co-administration of chemotherapy. We investigated the effect of perturbations of this pathway in breast cancers from patients treated with neoadjuvant anti-HER2-targeted therapy without chemotherapy. PATIENTS AND METHODS: Baseline tumor samples from patients with HER2-positive breast cancer enrolled in TBCRC006 (NCT00548184), a 12-week neoadjuvant clinical trial with lapatinib plus trastuzumab [plus endocrine therapy for estrogen receptor (ER)-positive tumors], were assessed for PTEN status by immunohistochemistry and PIK3CA mutations by sequencing...
November 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29109612/pilot-study-for-managing-complex-chronic-care-medicaid-patients-with-diabetes-using-a-mobile-health-application-achieves-triple-aim-improvement-in-a-primary-care-setting
#14
Marit L Bovbjerg, Jenney Lee, Rosa Wolff, Bobby Bangs, Michael A May
IN BRIEF Cost-effective innovations to improve health and health care in patients with complex chronic diseases are urgently needed. Mobile health (mHealth) remote monitoring applications (apps) are a promising technology to meet this need. This article reports on a study evaluating patients' use of a tablet device with an mHealth app and a cellular-enabled glucose meter that automatically uploaded blood glucose values to the app. Improvements were observed across all three components of the Patient Protection and Affordable Care Act's "triple aim...
October 2017: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29108918/donor-site-morbidity-of-the-anterolateral-thigh-flap
#15
Hannes Weise, Andreas Naros, Gunnar Blumenstock, Michael Krimmel, Sebastian Hoefert, Susanne Kluba, Stefan Hofer, Siegmar Reinert
INTRODUCTION: The purpose of this study was to investigate donor site morbidity after reconstruction of defects in the head and neck region with an anterolateral thigh (ALT) flap. METHODS: From 07/2006 to 12/2015 the anterolateral thigh flap was used for reconstruction of large intra- or extraoral defects in 138 patients. The donor sites were available to examine for morbidity in 51 patients (36.7%). All patients completed a standardized questionnaire, received a physical examination, and underwent isokinetic muscle exercises of the lower extremity with a Dynamometer...
September 30, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29103517/stability-and-bioactivity-of-chitosan-as-a-transfection-agent-in-primary-human-cell-cultures-a-case-for-chitosan-only-controls
#16
Tanya L Cupino, Billy A Watson, Alan C Cupino, Keiji Oda, Mark G Ghamsary, Salvador Soriano, Wolff M Kirsch
Chitosan polymers (Cs), from which microparticles (CsM) may be precipitated to deliver various intracellular payloads, are generally considered biologically inert. We examined the impact of cell culture conditions on CsM size and the effect of chitosan on CD59 expression in primary human smooth muscle cells. We found that particle concentration and incubation time in biological buffers augmented particle size. Between pH 7.0 and pH 7.5, CsM size increased abruptly. We utilized CsM containing a plasmid with a gene for CD59 (pCsM) to transfect cells...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29102798/three-dimensional-fabrication-of-thick-and-densely-populated-soft-constructs-with-complex-and-actively-perfused-channel-network
#17
C Rodrigo Pimentel, Suk Kyu Ko, Claudia Caviglia, Anders Wolff, Jenny Emnéus, Stephan Sylvest Keller, Martin Dufva
One of the fundamental steps needed to design functional tissues and, ultimately organs is the ability to fabricate thick and densely populated tissue constructs with controlled vasculature and microenvironment. To date, bioprinting methods have been employed to manufacture tissue constructs with open vasculature in a square-lattice geometry, where the majority lacks the ability to be directly perfused. Moreover, it appears to be difficult to fabricate vascular tissue constructs targeting the stiffness soft tissues such as the liver...
November 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29102200/quantitative-drinking-water-arsenic-concentrations-in-field-environments-using-mobile-phone-photometry-of-field-kits
#18
Ezazul Haque, Brian J Mailloux, Daisy de Wolff, Sabina Gilioli, Colette Kelly, Ershad Ahmed, Christopher Small, Kazi Matin Ahmed, Alexander van Geen, Benjamin C Bostick
Arsenic (As) groundwater contamination is common yet spatially heterogeneous within most environments. It is therefore necessary to measure As concentrations to determine whether a water source is safe to drink. Measurement of As in the field involves using a test strip that changes color in the presence of As. These tests are relatively inexpensive, but results are subjective and provide binned categorical data rather than exact determinations of As concentration. The goal of this work was to determine if photos of field kit test strips taken on mobile phone cameras could be used to extract more precise, continuous As concentrations...
October 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29100185/numerical-evaluation-of-bone-remodelling-and-adaptation-considering-different-hip-prosthesis-designs
#19
Ievgen Levadnyi, Jan Awrejcewicz, José Eduardo Gubaua, Jucélio Tomás Pereira
BACKGROUND: The change in mechanical properties of femoral cortical bone tissue surrounding the stem of the hip endoprosthesis is one of the causes of implant instability. We present an analysis used to determine the best conditions for long-term functioning of the bone-implant system, which will lead to improvement of treatment results. METHODS: In the present paper, a finite element method coupled with a bone remodelling model is used to evaluate how different three-dimensional prosthesis models influence distribution of the density of bone tissue...
October 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29097277/interfering-peptides-targeting-protein-protein-interactions-the-next-generation-of-drugs
#20
REVIEW
Heriberto Bruzzoni-Giovanelli, Valerie Alezra, Nicolas Wolff, Chang-Zhi Dong, Pierre Tuffery, Angelita Rebollo
Protein-protein interactions (PPIs) are well recognized as promising therapeutic targets. Consequently, interfering peptides (IPs) - natural or synthetic peptides capable of interfering with PPIs - are receiving increasing attention. Given their physicochemical characteristics, IPs seem better suited than small molecules to interfere with the large surfaces implicated in PPIs. Progress on peptide administration, stability, biodelivery and safety are also encouraging the interest in peptide drug development...
October 31, 2017: Drug Discovery Today
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