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https://www.readbyqxmd.com/read/29327175/microrna-30c-as-a-novel-diagnostic-biomarker-for-primary-and-secondary-b-cell-lymphoma-of-the-cns
#1
Alexander Baraniskin, Monika Chomiak, Guido Ahle, Thomas Gress, Malte Buchholz, Michael Turewicz, Martin Eisenacher, Michelle Margold, Uwe Schlegel, Wolff Schmiegel, Stephan Hahn, Roland Schroers
Primary lymphomas of the central nervous system (PCNSL) are highly aggressive tumors affecting exclusively the CNS, meninges, and eyes. PCNSL must be separated from secondary spread of systemic lymphoma to the CNS (SCNSL), which may occur at diagnosis or relapse of systemic lymphomas. At present, there are no valid methods to distinguish PCNSL from SCNSL based on tumor biopsy because of similar histological presentation. However, SCNSL and PCNSL are different in terms of prognosis and adequate therapy protocols...
January 11, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29324366/size-matters-the-olfactory-bulb-as-a-marker-for-depression
#2
F Rottstaedt, K Weidner, T Strauß, J Schellong, H Kitzler, S Wolff-Stephan, T Hummel, I Croy
BACKGROUND: Major Depression is mainly related to structural and functional alterations in brain networks involving limbic and prefrontal regions. Reduced olfactory sensitivity in depression is associated with reduced olfactory bulb (OB) volume. We determined if the OB volume reduction is a specific biomarker for depression and whether its diagnostic accuracy allows its use as a valid biomarker to support its diagnosis. METHODS: 84 in-patients with mixed mental disorders and 51 age-matched healthy controls underwent structural MR imaging with a spin-echo T2-wheighted sequence...
December 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29322235/-interrater-reliability-and-clinical-impact-of-the-post-ureteroscopic-lesion-scale-puls-grading-system-for-ureteral-lesions-after-ureteroscopy-results-of-the-german-prospective-multicenter-buster-project
#3
M May, M Schönthaler, C Gilfrich, I Wolff, J Peter, A Miernik, H-M Fritsche, M Burger, M Schostak, S Lebentrau
BACKGROUND: The Post-ureteroscopic Lesion Scale (PULS) was designed as a standardized classification system for ureteral lesions after uretero(reno)scopy (URS). This study evaluates its routine use and a possible clinical impact based on a representative patient cohort. MATERIALS AND METHODS: Data of 307 patients in 14 German centers within the BUSTER project were used to test 3 hypotheses (H): PULS score shows a high interrater reliability (IRR) after independent assessment by urologic surgeon and assistance personnel (H1); PULS score is correlated with the frequency of postoperative complications during hospital stay (H2); post-URS stenting of the ureter is associated with higher PULS scores (H3)...
January 10, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29317744/a-role-for-divalent-metal-transporter-dmt1-in-mitochondrial-uptake-of-iron-and-manganese
#4
Natascha A Wolff, Michael D Garrick, Lin Zhao, Laura M Garrick, Andrew J Ghio, Frank Thévenod
Much of iron and manganese metabolism occurs in mitochondria. Uptake of redox-active iron must be tightly controlled, but little is known about how metal ions enter mitochondria. Recently, we established that the divalent metal transporter 1 (DMT1) is present in the outer mitochondrial membrane (OMM). Therefore we asked if it mediates Fe2+ and Mn2+ influx. Mitochondria were isolated from HEK293 cells permanently transfected with inducible rat DMT1 isoform 1 A/+IRE (HEK293-rDMT1). Fe2+-induced quenching of the dye PhenGreen™SK (PGSK) occurred in two phases, one of which reflected OMM DMT1 with stronger Fe2+ uptake after DMT1 overexpression...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316261/arrhythmia-after-cone-repair-for-ebstein-anomaly-the-mayo-clinic-experience-in-143-young-patients
#5
Philip Wackel, Bryan Cannon, Joseph Dearani, Kristen Sessions, Kimberly Holst, Jonathan Johnson, Frank Cetta
BACKGROUND: The increased incidence of preoperative and postoperative arrhythmia in Ebstein anomaly (EA) prompted some clinicians to perform an electrophysiology study (EPS) in all patients prior to surgery for EA. The cone repair (CR) is the current surgical option of choice for most young patients with EA but the effect of the CR on arrhythmia is not well established. OBJECTIVES: To assess the burden of arrhythmia in young patients after CR and to assess the utility of selective preoperative EPS...
January 8, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29305187/cardiac-arrest-and-ventricular-arrhythmia-in-adults-with-ebstein-anomaly-and-left-ventricular-non-compaction
#6
Magdalena Kumor, Magdalena Lipczyńska, Elzbieta Katarzyna Biernacka, Anna Klisiewicz, Anna Wójcik, Marek Konka, Katarzyna Kożuch, Piotr Szymański, Piotr Hoffman
BACKGROUND: Ebstein anomaly is a complex, congenital heart defect that is associated with a variety of cardiac abnormalities. Studies found a similar sarcomere gene mutation in patients with Ebstein anomaly (EA) and patients with isolated left ventricular non-compaction (LVNC). AIM: We aimed to show the prevalence of LVNC and its potential relationship with severe cardiac events (VT - ventricular tachycardia, cardiac arrest) in adult patients with EA. METHODS: We conducted a retrospective search of our institutional database from 2010 to 2014 for patients with EA and reviewed patients' medical records (age, sex, clinical presentation, electrocardiographic, echocardiographic, and CMR - cardiac magnetic resonance features)...
January 2, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29302285/implant-failure-and-history-of-failed-endodontic-treatment-a-retrospective-case-control-study
#7
Georgios S Chatzopoulos, Larry F Wolff
Background: Residual bacterial biofilm and/or bacteria in planktonic form may be survived in the bone following an extraction of an infected tooth that was endodontically treated unsuccessfully Failed endodontic treatment may be associated with failure of implants to osseointegrate in the same sites. Therefore, the aim of this retrospective case-control study is to examine the risk of implant failure in previous failed endodontic sites. Material and Methods: This retrospective case-control study is based on 94 dental records of implants placed at the University of Minnesota School of Dentistry...
November 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29302080/infrequently-expressed-mirnas-in-colorectal-cancer-tissue-and-tumor-molecular-phenotype
#8
Martha L Slattery, Frances Y Lee, Andrew J Pellatt, Lila E Mullany, John R Stevens, Wade S Samowitz, Roger K Wolff, Jennifer S Herrick
This corrects the article DOI: 10.1038/modpathol.2017.38.
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29299907/self-assembled-layering-of-magnetic-nanoparticles-in-a-ferrofluid-at-silicon-surfaces
#9
Katharina Theis-Broehl, Erika C Vreeland, Andrew Gomez, Dale L Huber, Apurve Saini, Max Wolff, Brian Maranville, Erik Brok, Kathryn L Krycka, Joseph A Dura, Julie A Borchers
This article describes the 3D self-assembly of monodisperse colloidal magnetite nanoparticles from a dilute water-based ferrouid onto a silicon surface and the dependence of the resultant magnetic structure with applied field. The nanoparticles assemble into close-packed layers at the surface followed by more loosely-packed ones. The magnetic field-dependent magnetization of the individual nanoparticle layers depends on both the rotational freedom of the layer and the magnetization of the adjacent layers. For layers in which the nanoparticles are more free to rotate, the easy axis of the nanoparticle can readily orient along the field direction...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29298659/cardiac-manifestations-of-prkag2-mutation
#10
Pooya Banankhah, Gregory A Fishbein, Anthony Dota, Reza Ardehali
BACKGROUND: The Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2 (PRKAG2) cardiac syndrome is characterized by glycogen accumulation in the cardiac tissue. The disease presents clinically with hypertrophic cardiomyopathy (HCM), and it is often associated with conduction abnormalities. CASE PRESENTATION: A 23 year-old female with history of Wolff-Parkinson-White (WPW) and HCM presented for evaluation after an episode of Non-ST Elevation Myocardial Infarction (NSTEMI)...
January 3, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29298482/wolff-cope-approach-to-the-ab-ring-of-the-sesterterpenoid-variecolin
#11
Michael R Krout, Christopher Edwin Henry, Thomas Jensen, Kun-Liang Phil Wu, Scott C Virgil, Brian M Stoltz
A stereoselective synthesis of the AB ring of the complex sesterterpenoid variecolin is presented. Our strategy features the development of a tandem Wolff/Cope rearrangement of α-diazo cyclobutyl ketones for the construction of fused, eight-membered carbocycles. Preliminary studies revealed a facile Wolff rearrangement but a difficult vinyl ketene cyclobutane Cope rearrangement. We have leveraged an efficient microwave-promoted tandem rearrangement to prepare the desired functionalized cyclooctadienones that we envision as potential key intermediates in the convergent synthesis of variecolin...
January 4, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29298192/helping-older-adults-improve-their-medication-experience-home-by-addressing-medication-regimen-complexity-in-home-healthcare
#12
Orla C Sheehan, Hadi Kharrazi, Kimberly J Carl, Bruce Leff, Jennifer L Wolff, David L Roth, Jennifer Gabbard, Cynthia M Boyd
In skilled home healthcare (SHHC), communication between nurses and physicians is often inadequate for medication reconciliation and needed changes to the medication regimens are rarely made. Fragmentation of electronic health record (EHR) systems, transitions of care, lack of physician-nurse in-person contact, and poor understanding of medications by patients and their families put patients at risk for serious adverse outcomes. The aim of this study was to develop and test the HOME tool, an informatics tool to improve communication about medication regimens, share the insights of home care nurses with physicians, and highlight to physicians and nurses the complexity of medication schedules...
January 2018: Home Healthcare Now
https://www.readbyqxmd.com/read/29295629/reply-re-global-health-resource-utilization-associated-with-pacemaker-complications
#13
Catherine Waweru, Anna Steenrod, Claudia Wolff, Simon Eggington, David Jay Wright, Kathleen W Wyrwich
No abstract text is available yet for this article.
January 3, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29289352/-erratum-to-prise-en-charge-de-la-dmla-exsudative-en-france-en-2015-j-fr-ophtalmol-40-9-2017-723-30
#14
J Zerbib, A Bourhis, P L Cornut, F De Bats, T Grenet, V Gualino, J Halfon, H Massé, M Srour, M Streho, S Tick, B Wolff, N San Nicolas
No abstract text is available yet for this article.
December 27, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29287678/the-who-tailoring-immunization-programmes-tip-approach-review-of-implementation-to-date
#15
Eve Dubé, Julie Leask, Brent Wolff, Benjamin Hickler, Victor Balaban, Everold Hosein, Katrine Habersaat
INTRODUCTION: The WHO Regional Office for Europe developed the Guide to tailoring immunization programmes (TIP), offering countries a process through which to diagnose barriers and motivators to vaccination in susceptible low vaccination coverage and design tailored interventions. A review of TIP implementation was conducted in the European Region. MATERIAL AND METHODS: The review was conducted during June to December 2016 by an external review committee and was based on visits in Bulgaria, Lithuania, Sweden and the United Kingdom that had conducted a TIP project; review of national and regional TIP documents and an online survey of the Member States in the WHO European Region that had not conducted a TIP project...
December 26, 2017: Vaccine
https://www.readbyqxmd.com/read/29283379/a-metabolomic-and-lipidomic-serum-signature-from-nonhuman-primates-administered-with-a-promising-radiation-countermeasure-gamma-tocotrienol
#16
Amrita K Cheema, Khyati Y Mehta, Oluseyi O Fatanmi, Stephen Y Wise, Charles P Hinzman, Josh Wolff, Vijay K Singh
The development of radiation countermeasures for acute radiation syndrome (ARS) has been underway for the past six decades, leading to the identification of multiple classes of radiation countermeasures. However, to date, only two growth factors (Neupogen and Neulasta) have been approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiation syndrome (H-ARS). No radioprotector for ARS has been approved by the FDA yet. Gamma-tocotrienol (GT3) has been demonstrated to have radioprotective efficacy in murine as well as nonhuman primate (NHP) models...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29282701/towards-icf-implementation-in-menopause-healthcare-a-systematic-review-of-icf-application-in-switzerland
#17
Martina Zangger, Dagmar Poethig, Florian Meissner, Michael von Wolff, Petra Stute
AIMS OF THE STUDY: To present a systematic literature review on the application and degree of implementation of the International Classification of Functioning, Disability and Health (ICF) across different health conditions and regions in Switzerland in order to develop an ICF classification of the climacteric syndrome in the medium term. METHODS: A systematic literature search was conducted through Embase and Medline covering the period between 2011 and August 2016...
December 28, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29279917/trends-in-self-reported-and-biochemically-tested-marijuana-use-among-pregnant-females-in-california-from-2009-2016
#18
Kelly C Young-Wolff, Lue-Yen Tucker, Stacey Alexeeff, Mary Anne Armstrong, Amy Conway, Constance Weisner, Nancy Goler
No abstract text is available yet for this article.
December 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29278862/frontal-fibrosing-alopecia-a-retrospective-analysis-of-72-patients-from-a-german-academic-center
#19
Markus V Heppt, Valerie Letulé, Ieva Laniauskaite, Markus Reinholz, Julia K Tietze, Hans Wolff, Thomas Ruzicka, Elke C Sattler
Frontal fibrosing alopecia (FFA) describes the scarring, band-like recession of the frontotemporal hairline. Treatment is difficult, and currently, no evidence-based therapy exists. The purpose of this study is to report clinical features and treatment responses in a large cohort of patients with FFA. The authors analyzed a series of 72 patients with a clinical or histologic diagnosis of FFA. A total of 70 patients were female (97.2%), and 2 were male (2.8%). In females, the first onset of FFA was postmenopausal in 81...
December 26, 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29278459/antiviral-activity-of-faramea-hyacinthina-and-faramea-truncata-leaves-on-dengue-virus-type-2-and-their-major-compounds
#20
Rodolfo S Barboza, Ligia M M Valente, Thiago Wolff, Iranaia Assunção-Miranda, Rômulo S L Neris, Iris P Guimarães-Andrade, Mário Gomes
The defatted fractions of the Faramea hyacinthina and F. truncata (Rubiaceae) leaf MeOH extracts showed in vitro non-cytotoxic and anti-dengue virus serotype 2 (DENV2) activity in human hepatocarcinoma cell lineage (HepG2). Submitting these fractions to the developed RP-SPE method allowed isolating the antiviral flavanone (2S)-isosakuranetin-7-O-β-D-apiofuranosyl(1→6)-β-D-glucopyranoside (1) from both species and yielded less active sub-fractions. The new diasteroisomeric epimer pair 2S + 2R of 5,3',5'-trihydroxy-flavanone-7-O-β-D-apiofuranosyl(1→6)-β-D-glucopyranoside (2a/2b) from F...
December 26, 2017: Chemistry & Biodiversity
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