keyword
https://read.qxmd.com/read/38534490/deep-learning-for-generalized-eeg-seizure-detection-after-hypoxia-ischemia-preclinical-validation
#1
JOURNAL ARTICLE
Hamid Abbasi, Joanne O Davidson, Simerdeep K Dhillon, Kelly Q Zhou, Guido Wassink, Alistair J Gunn, Laura Bennet
Brain maturity and many clinical treatments such as therapeutic hypothermia (TH) can significantly influence the morphology of neonatal EEG seizures after hypoxia-ischemia (HI), and so there is a need for generalized automatic seizure identification. This study validates efficacy of advanced deep-learning pattern classifiers based on a convolutional neural network (CNN) for seizure detection after HI in fetal sheep and determines the effects of maturation and brain cooling on their accuracy. The cohorts included HI-normothermia term ( n = 7), HI-hypothermia term ( n = 14), sham-normothermia term ( n = 5), and HI-normothermia preterm ( n = 14) groups, with a total of >17,300 h of recordings...
February 24, 2024: Bioengineering
https://read.qxmd.com/read/38493062/temperature-management-in-acute-brain-injury-a-narrative-review
#2
REVIEW
Eva Esther Tejerina Álvarez, José Ángel Lorente Balanza
Temperature management has been used in patients with acute brain injury resulting from different conditions, such as post-cardiac arrest hypoxic-ischaemic insult, acute ischaemic stroke, and severe traumatic brain injury. However, current evidence offers inconsistent and often contradictory results regarding the clinical benefit of this therapeutic strategy on mortality and functional outcomes. Current guidelines have focused mainly on active prevention and treatment of fever, while therapeutic hypothermia (TH) has fallen into disuse, although doubts persist as to its effectiveness according to the method of application and appropriate patient selection...
March 15, 2024: Medicina intensiva
https://read.qxmd.com/read/38469401/emerging-therapeutic-strategies-in-hypoxic-ischemic-encephalopathy-a-focus-on-cognitive-outcomes
#3
REVIEW
Kethely L Marques, Victor Rodrigues, Cassiana T N Balduci, Guilherme C Montes, Penha C Barradas, Marta C Cunha-Rodrigues
Perinatal hypoxia-ischemia represents a significant risk to CNS development, leading to high mortality rates, diverse damages, and persistent neurological deficits. Despite advances in neonatal medicine in recent decades, the incidence of HIE remains substantial. Motor deficits can manifest early, while cognitive impairments may be diagnosed later, emphasizing the need for extended follow-up. This review aims to explore potential candidates for therapeutic interventions for hypoxic-ischemic encephalopathy (HIE), with a focus on cognitive deficits...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38442443/plasmatic-profiles-of-cytokines-chemokines-glial-fibrillary-acidic-protein-gfap-and-mri-brain-damage-in-neonates-with-hypoxic-ischemic-encephalopathy-hie
#4
JOURNAL ARTICLE
Cinzia Auriti, Vito Mondì, Fiammetta Piersigilli, Laura Timelli, Tamara Del Pinto, Giusi Prencipe, Giulia Lucignani, Daniela Longo, Iliana Bersani
BACKGROUND: Perinatal hypoxia triggers the release of cytokines and chemokines by neurons, astrocytes and microglia. In response to hypoxia-ischemia resting/ramified microglia proliferate and undergo activation, producing proinflammatory molecules. The brain damage extension seems to be related to both the severity of hypoxia and the balance between pro and anti-inflammatory response and can be explored with neuroimaging. AIMS: The aim of this preliminary study was to explore possible relationships between plasma levels of inflammatory cytokines/chemokines and the severe brain damage detectable by Magnetic Resonance Imaging (MRI), performed during the hospitalization...
May 2024: Cytokine
https://read.qxmd.com/read/38393618/the-role-of-apoe-in-fatty-acid-transport-from-neurons-to-astrocytes-under-ischemia-hypoxia-conditions
#5
JOURNAL ARTICLE
Hongyan Chen, Shaozhi Zhao, Qiang Jian, Yinfang Yan, Simin Wang, Xinwen Zhang, Yuqiang Ji
BACKGROUND: The aim of this study was to investigate whether ischemia/hypoxia conditions induce fatty acid transport from neurons to astrocytes and whether this mechanism is affected by ApoE isoforms. METHODS AND RESULTS: A neonatal rat model of hypoxic-ischemic brain damage was established. Excessive accumulation of lipid droplets and upregulation of ApoE expression occurred in the hippocampus and cerebral cortex after hypoxia-ischemia, which implied the occurrence of abnormal fatty acid metabolism...
February 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38375125/hypoxic-ischemic-encephalopathy-indicators-of-sarnat-and-sarnat-scoring-in-neonatal-subjects-with-perinatal-asphyxia
#6
JOURNAL ARTICLE
Parvaneh Sadeghi Moghaddam, Mohammad Aghaali, Seyede Zeinab Modarresy, Samira Shahhamzei, Maryam Aljaboori
OBJECTIVES: Hypoxic-ischemic encephalopathy (HIE) is still a relevant cause of neonatal mortality and morbidity. HIE severity can predict long-term outcomes. Sarnat staging is one of the most common methods used to evaluate HIE severity. However, an ongoing urge exists to find other accurate and affordable ways to accompany this clinical staging for HIE. This study aimed to evaluate the relationship between cerebral arteries' resistive indices and other hypoxic-ischemic encephalopathy indicators using Sarnat scoring of newborns subjected to perinatal asphyxia...
2024: Iranian Journal of Child Neurology
https://read.qxmd.com/read/38341076/catalpol-alleviates-hypoxia-ischemia-induced-brain-damage-by-inhibiting-ferroptosis-through-the-pi3k-nrf2-system-xc-gpx4-axis-in-neonatal-rats
#7
JOURNAL ARTICLE
Jingjing Lin, Lu Deng, Ailin Qi, Hong Jiang, Di Xu, Yuehui Zheng, Zixuan Zhang, Xiaoman Guo, Beilei Hu, Peijun Li
Hypoxic-ischemic encephalopathy (HIE) is a brain damage caused by perinatal hypoxia and blood flow reduction. Severe HIE leads to death. Available treatments remain limited. Oxidative stress and nerve damage are major factors in brain injury caused by HIE. Catalpol, an iridoid glucoside found in the root of Rehmannia glutinosa, has antioxidant and neuroprotective effects. This study examined the neuroprotective effects of catalpol using a neonatal rat HIE model and found that catalpol might protect the brain through inhibiting neuronal ferroptosis and ameliorating oxidative stress...
February 8, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38338726/high-doses-of-ana12-improve-phenobarbital-efficacy-in-a-model-of-neonatal-post-ischemic-seizures
#8
JOURNAL ARTICLE
Preeti Vyas, Ira Chaturvedi, Yun Hwang, Joseph Scafidi, Shilpa D Kadam, Carl E Stafstrom
Phenobarbital (PB) remains the first-line medication for neonatal seizures. Yet, seizures in many newborns, particularly those associated with perinatal ischemia, are resistant to PB. Previous animal studies have shown that in postnatal day P7 mice pups with ischemic stroke induced by unilateral carotid ligation, the tyrosine receptor kinase B (TrkB) antagonist ANA12 (N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide, 5 mg/kg) improved the efficacy of PB in reducing seizure occurrence...
January 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38317333/hyperpolarized-13-c-magnetic-resonance-imaging-in-neonatal-hypoxic-ischemic-encephalopathy-first-investigations-in-a-large-animal-model
#9
JOURNAL ARTICLE
Ted C K Andelius, Esben S S Hansen, Nikolaj Bøgh, Mette V Pedersen, Kasper J Kyng, Tine B Henriksen, Christoffer Laustsen
Early biomarkers of cerebral damage are essential for accurate prognosis, timely intervention, and evaluation of new treatment modalities in newborn infants with hypoxia and ischemia at birth. Hyperpolarized 13 C magnetic resonance imaging (MRI) is a novel method with which to quantify metabolism in vivo with unprecedented sensitivity. We aimed to investigate the applicability of hyperpolarized 13 C MRI in a newborn piglet model and whether this method may identify early changes in cerebral metabolism after a standardized hypoxic-ischemic (HI) insult...
February 5, 2024: NMR in Biomedicine
https://read.qxmd.com/read/38267942/detailed-statistical-analysis-plan-for-albino-effect-of-allopurinol-in-addition-to-hypothermia-for-hypoxic-ischemic-brain-injury-on-neurocognitive-outcome-a-blinded-randomized-placebo-controlled-parallel-group-multicenter-trial-for-superiority-phase-iii
#10
RANDOMIZED CONTROLLED TRIAL
Corinna Engel, Mario Rüdiger, Manon J N L Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Ana Vilan, Mari Falck, Isabella Mauro, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht, Roselinda van der Vlught, Axel R Franz
BACKGROUND: Despite therapeutic hypothermia (TH) and neonatal intensive care, 45-50% of children affected by moderate-to-severe neonatal hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective therapies are sought, besides TH, to further improve the outcome of affected infants. Allopurinol - a xanthine oxidase inhibitor - reduced the production of oxygen radicals and subsequent brain damage in pre-clinical and preliminary human studies of cerebral ischemia and reperfusion, if administered before or early after the insult...
January 24, 2024: Trials
https://read.qxmd.com/read/38235171/intranasal-insulin-attenuates-hypoxia-ischemia-induced-short-term-sensorimotor-behavioral-disturbances-neuronal-apoptosis-and-brain-damage-in-neonatal-rats
#11
JOURNAL ARTICLE
Chirag P Talati, Jonathan W Lee, Silu Lu, Norma B Ojeda, Varsha Prakash, Nilesh Dankhara, Tanner C Nielson, Sara P Sandifer, Gene L Bidwell, Yi Pang, Lir-Wan Fan, Abhay J Bhatt
There is a significant need for additional therapy to improve outcomes for newborns with acute Hypoxic-ischemic (HI) encephalopathy (HIE). New evidence suggests that insulin could be neuroprotective. This study aimed to investigate whether intranasal insulin attenuates HI-induced brain damage and neurobehavioral dysfunction in neonatal rats. Postnatal day 10 (P10), Sprague-Dawley rat pups were randomly divided into Sham + Vehicle, Sham + Insulin, HI + Vehicle, and HI + Insulin groups with equal male-to-female ratios...
2024: Current research in neurobiology
https://read.qxmd.com/read/38185204/early-hyperoxemia-and-2-year-outcomes-in-infants-with-hypoxic-ischemic-encephalopathy-a-secondary-analysis-of-the-infant-cooling-evaluation-ice-trial
#12
JOURNAL ARTICLE
Shiraz Badurdeen, Jeanie L Y Cheong, Susan Donath, Hamish Graham, Stuart B Hooper, Graeme R Polglase, Sue Jacobs, Peter G Davis
OBJECTIVE: To determine the causal relationship between exposure to early hyperoxemia and death or major disability in infants with hypoxic-ischemic encephalopathy (HIE). STUDY DESIGN: We analyzed data from the Infant Cooling Evaluation (ICE) trial that enrolled newborns ≥35 weeks' gestation with moderate-severe HIE, randomly allocated to hypothermia or normothermia. The primary outcome was death or major sensorineural disability at 2 years. We included infants with arterial pO2 measured within 2 hours of birth...
January 5, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38178264/trkb-mediated-sustained-neuroprotection-is-sex-specific-and-formula-see-text-dependent-in-adult-mice-following-neonatal-hypoxia-ischemia
#13
JOURNAL ARTICLE
Vishal Chanana, Margaret Hackett, Nazli Deveci, Nur Aycan, Burak Ozaydin, Nur Sena Cagatay, Damla Hanalioglu, Douglas B Kintner, Karson Corcoran, Sefer Yapici, Furkan Camci, Jens Eickhoff, Karyn M Frick, Peter Ferrazzano, Jon E Levine, Pelin Cengiz
BACKGROUND: Neonatal hypoxia ischemia (HI) related brain injury is one of the major causes of life-long neurological morbidities that result in learning and memory impairments. Evidence suggests that male neonates are more susceptible to the detrimental effects of HI, yet the mechanisms mediating these sex-specific responses to neural injury in neonates remain poorly understood. We previously tested the effects of treatment with a small molecule agonist of the tyrosine kinase B receptor (TrkB), 7,8-dihydroxyflavone (DHF) following neonatal HI and determined that females, but not males exhibit increased phosphorylation of TrkB and reduced apoptosis in their hippocampi...
January 4, 2024: Biology of Sex Differences
https://read.qxmd.com/read/38101694/volumetric-changes-in-brain-mri-of-infants-with-hypoxic-ischemic-encephalopathy-and-abnormal-neurodevelopment-who-underwent-therapeutic-hypothermia
#14
JOURNAL ARTICLE
Soo-Ah Im, Emi Tomita, Moon Yeon Oh, Sae Yun Kim, Hyun Mi Kang, Young-Ah Youn
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is a severe neonatal complication that can result in 40-60 % of long-term morbidity. Magnetic Resonance Imaging (MRI) is a noninvasive method which is usually performed before discharge to visually assess acquired cerebral lesions associated with HIE and severity of lesions possibly providing a guide for detecting adverse outcomes. This study aims to evaluate the impact of HIE on brain volume changes observed in MRI scans performed at a mean 10 days of life, which can serve as a prognostic indicator for abnormal neurodevelopmental (ND) outcomes at 18-24 months among HIE infants...
February 15, 2024: Brain Research
https://read.qxmd.com/read/38089686/no-neuroprotective-effect-of-therapeutic-hypothermia-following-lipopolysaccharide-sensitized-hypoxia-ischemia-a-newborn-piglet-study
#15
JOURNAL ARTICLE
Mads Andersen, Hannah Brogård Andersen, Ted Carl Kejlberg Andelius, Lærke Hjøllund Hansen, Regitze Pinnerup, Mette Bjerre, Steffen Ringgaard, Leslie Schwendimann, Pierre Gressens, Kasper Jacobsen Kyng, Tine Brink Henriksen
INTRODUCTION: Therapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic hypothermia may benefit newborns subjected to infection or inflammation before a hypoxic-ischemic insult. We aimed to compare newborn piglets with lipopolysaccharide-sensitized hypoxia-ischemia treated with and without therapeutic hypothermia with regards to measures of neuroprotection. METHODS: A total of 32 male and female piglets were included in this randomized experimental study...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38069249/postischemic-infusion-of-apigenin-reduces-seizure-burden-in-preterm-fetal-sheep
#16
JOURNAL ARTICLE
Kenta H T Cho, Natalya Hounsell, Evelyn McClendon, Art Riddle, Basappa, Simerdeep K Dhillon, Laura Bennet, Stephen Back, Larry S Sherman, Alistair J Gunn, Justin M Dean
Seizures are common in preterm newborns and are associated with poor neurodevelopmental outcomes. Current anticonvulsants have poor efficacy, and many have been associated with upregulation of apoptosis in the developing brain. Apigenin, a natural bioactive flavonoid, is a potent inhibitor of hyaluronidase and reduces seizures in adult animal models. However, its impact on perinatal seizures is unclear. In the present study, we examined the effect of apigenin and S3, a synthetic, selective hyaluronidase inhibitor, on seizures after cerebral ischemia in preterm fetal sheep at 0...
November 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38036441/potential-adjuncts-to-therapeutic-hypothermia-to-mitigate-multiorgan-injury-in-perinatal-hypoxia-ischemia
#17
REVIEW
Megan J Turner, Robert M Dietz
Over the last 2 decades, therapeutic hypothermia has become the standard of care to reduce morbidity and mortality in neonates affected by moderate-to-severe hypoxic-ischemic encephalopathy (HIE). There is a significant interest in improving the neurologic outcomes of neonatal HIE, ranging from adjunctive therapy to therapeutic hypothermia. Importantly, the pathophysiologic mechanisms underlying HIE also affect multiple other organs, contributing to high morbidity and mortality in this patient population. This review focuses on the adjunct therapies currently under investigation to mitigate the impact of hypoxic-ischemic injury on the brain, kidneys, liver, heart, and gastrointestinal system...
December 1, 2023: NeoReviews
https://read.qxmd.com/read/38015765/the-glun2b-containing-nmda-receptor-alleviates-neuronal-apoptosis-in-neonatal-hypoxic-ischemic-encephalopathy-by-activating-pi3k-akt-creb-signaling-pathwa
#18
JOURNAL ARTICLE
X Zhang, K-Z Peng, S-L Xu, M-X Wu, H-J Sun, J Zhao, S Yang, S-J Liu, C-Y Lia, X-M Zhang
Neonatal hypoxic-ischemic encephalopathy (HIE) is a disease caused by insufficient blood supply in the brain in newborns during the perinatal period. Severe HIE leads to patient death, and patients with mild HIE are at increased risk of cognitive deficits and behavioral abnormalities. The NMDA receptor is an important excitatory receptor in the central nervous system, and in adult hypoxic-ischemic injury both subtypes of the NMDA receptor play important but distinct roles. The GluN2A-containing NMDA receptor (GluN2A-NMDAR) could activate neuronal protective signaling pathway, while the GluN2B-NMDAR subtype is coupled to the apoptosis-inducing signaling pathway and leads to neuronal death...
November 28, 2023: Physiological Research
https://read.qxmd.com/read/38012640/hypothermia-combined-with-extracellular-vesicles-from-clonally-expanded-immortalized-mesenchymal-stromal-cells-improves-neurodevelopmental-impairment-in-neonatal-hypoxic-ischemic-brain-injury
#19
JOURNAL ARTICLE
Nicole Labusek, Parnian Ghari, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Martin Hadamitzky, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel, Josephine Herz
BACKGROUND: Neonatal encephalopathy following hypoxia-ischemia (HI) is a leading cause of childhood death and morbidity. Hypothermia (HT), the only available but obligatory therapy is limited due to a short therapeutic window and limited efficacy. An adjuvant therapy overcoming limitations of HT is still missing. Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) have shown promising therapeutic effects in various brain injury models. Challenges associated with MSCs' heterogeneity and senescence can be mitigated by the use of EVs from clonally expanded immortalized MSCs (ciMSCs)...
November 27, 2023: Journal of Neuroinflammation
https://read.qxmd.com/read/38006967/time-to-reaching-target-cooling-temperature-and-2-year-outcomes-in-infants-with-hypoxic-ischemic-encephalopathy
#20
JOURNAL ARTICLE
Rakesh Rao, Bryan A Comstock, Tai-Wei Wu, Ulrike Mietzsch, Dennis E Mayock, Fernando F Gonzalez, Thomas R Wood, Patrick J Heagerty, Sandra E Juul, Yvonne W Wu
OBJECTIVE: To determine if time to reaching target temperature (TT) is associated with death or neurodevelopmental impairment (NDI) at 2 years of age in infants with hypoxic-ischemic encephalopathy (HIE). STUDY DESIGN: Newborn infants ≥36 weeks of gestation diagnosed with moderate or severe HIE and treated with therapeutic hypothermia were stratified based on time at which TT was reached, defined as early (ie, ≤4 hours of age) or late (>4 hours of age)...
November 23, 2023: Journal of Pediatrics
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