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https://www.readbyqxmd.com/read/27911956/adenosine-stimulate-proliferation-and-migration-in-triple-negative-breast-cancer-cells
#1
Miriam Fernandez-Gallardo, Ricardo González-Ramírez, Alejandro Sandoval, Ricardo Felix, Eduardo Monjaraz
Emerging evidence suggests that the adenosine (Ado) receptors may play crucial roles in tumor progression. Here, we show that Ado increases proliferation and migration in a triple negative breast cancer model, the MDA-MB 231 cell line. The use of specific agonists and antagonists evidenced that these effects depend on the activation of the A2B receptor, which then triggers an intracellular response mediated by the adenylate cyclase/PKA/cAMP signaling pathway. Ado also increases the expression of NaV1.5 channels, a potential biomarker in breast cancer...
2016: PloS One
https://www.readbyqxmd.com/read/27898501/off-label-use-of-amplatzer-duct-occluder-ii-additional-sizes
#2
Heba T Mahmoud, Giuseppe Santoro, Cristina Capogrosso, Maria G Russo
OBJECTIVE: To report our experience on novel, off-label use of Amplatzer Duct Occluder type II additional sizes (ADO II-AS) device (St. Jude Medical, Inc.; St. Paul, Minnesota, USA) to manage nonduct shunt lesions. METHODS AND RESULTS: Among the 114 patients submitted to ADO II-AS implantation at our institution, 12 received this device as off-label treatment of paravalvular leak (n = 5), sinus of Valsalva fissuration (n = 2), accessory atrial septal defect (n = 2), muscular ventricular septal defect (n = 1), bleeding bronchial artery aneurysm (n = 1) and reverse shunt due to abnormal origin of left subclavian artery from pulmonary artery (n = 1)...
November 24, 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/27897270/trueprime-is-a-novel-method-for-whole-genome-amplification-from-single-cells-based-on-tthprimpol
#3
Ángel J Picher, Bettina Budeus, Oliver Wafzig, Carola Krüger, Sara García-Gómez, María I Martínez-Jiménez, Alberto Díaz-Talavera, Daniela Weber, Luis Blanco, Armin Schneider
Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a potent primase activity preferring dNTPs as substrates unlike conventional primases. A combination of TthPrimPol's unique ability to synthesize DNA primers with the highly processive Phi29 DNA polymerase (Φ29DNApol) enables near-complete whole genome amplification from single cells...
November 29, 2016: Nature Communications
https://www.readbyqxmd.com/read/27893232/narrative-production-in-children-with-autism-spectrum-disorder-asd-and-children-with-attention-deficit-hyperactivity-disorder-adhd-similarities-and-differences
#4
Sanne J M Kuijper, Catharina A Hartman, Suzanne T M Bogaerds-Hazenberg, Petra Hendriks
The present study focuses on the similarities and differences in language production between children with autism spectrum disorder (ASD) and children with attention-deficit/hyperactivity disorder (ADHD). In addition, we investigated whether Theory of Mind (ToM), working memory, and response inhibition are associated with language production. Narratives, produced by 106 Dutch-speaking children (36 with ASD, 34 with ADHD, and 36 typically developing) aged 6 to 12 during ADOS assessment, were examined on several linguistic measures: verbal productivity, speech fluency, syntactic complexity, lexical semantics, and discourse pragmatics...
November 28, 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27885547/identifying-high-ability-children-with-dsm-5-autism-spectrum-or-social-communication-disorder-performance-on-autism-diagnostic-instruments
#5
Megan Foley-Nicpon, Staci L Fosenburg, Kristin G Wurster, Susan G Assouline
This study was a replication of Mazefsky et al.'s (Journal of Autism and Developmental Disabilities 43:1236-1242, 2013) investigation among a sample of 45 high ability children and adolescents diagnosed with ASD under DSM-IV-TR. Items from the ADOS and ADI-R were mapped onto DSM-5 diagnostic criteria for ASD and SCD to determine whether participants would meet either diagnosis under DSM-5. If the ADOS were administered alone, 62% of individuals diagnosed with ASD would no longer meet criteria under DSM-5; however, when the ADI-R and ADOS scores were combined, 100% of individuals would continue to meet ASD diagnosis...
November 24, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27879050/structural-studies-of-protein-arginine-methyltransferase-2-reveal-its-interactions-with-potential-substrates-and-inhibitors
#6
Vincent Cura, Nils Marechal, Nathalie Troffer-Charlier, Jean-Marc Strub, Matthijs J van Haren, Nathaniel I Martin, Sarah Cianférani, Luc Bonnefond, Jean Cavarelli
: PRMT2 is the less-characterized member of the protein arginine methyltransferase family in terms of structure, activity, and cellular functions. PRMT2 is a modular protein containing a catalytic Ado-Met-binding domain and unique Src homology 3 domain that binds proteins with proline-rich motifs. PRMT2 is involved in a variety of cellular processes and has diverse roles in transcriptional regulation through different mechanisms depending on its binding partners. PRMT2 has been demonstrated to have weak methyltransferase activity on a histone H4 substrate, but its optimal substrates have not yet been identified...
November 5, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27878712/much-ado-about-nothing-the-financial-impact-of-physician-owned-specialty-hospitals
#7
Sujoy Chakravarty
The U.S. hospital industry has recently witnessed a number of policy changes aimed at aligning hospital payments to costs and these can be traced to significant concerns regarding selection of profitable patients and procedures by physician-owned specialty hospitals. The policy responses to specialty hospitals have alternated between payment system reforms and outright moratoriums on hospital operations including one in the recently enacted Affordable Care Act. A key issue is whether physician-owned specialty hospitals pose financial strain on the larger group of general hospitals through cream-skimming of profitable patients, yet there is no study that conducts a systematic analysis relating such selection behavior by physician-owners to financial impacts within hospital markets...
June 2016: Int J Health Econ Manag
https://www.readbyqxmd.com/read/27872093/a-novel-platinum-ii-based-bifunctional-adc-linker-benchmarked-using-89zr-desferal-and-auristatin-f-conjugated-trastuzumab
#8
Niels J Sijbrandi, Eugen Merkul, Joey A Muns, Dennis Cj Waalboer, Kevin Adamzek, Marije Bolijn, Veronica Montserrat, Govert W Somsen, Rob Haselberg, Paul Jgm Steverink, Hendrik-Jan Houthoff, Guus A M S van Dongen
Greater control is desirable in the stochastic conjugation technology used to synthesize antibody-drug conjugates (ADCs). We have shown recently that a fluorescent dye can be stably conjugated to a monoclonal antibody (mAb) using a bifunctional platinum(II) linker. Here we describe the general applicability of this novel linker technology for the preparation of stable and efficacious ADCs. The ethylenediamineplatinum(II) moiety, herein called Lx®, was coordinated to Desferal® (DFO) or auristatin F (AF) to provide storable "semi-final" products, which were directly conjugated to unmodified mAbs...
November 21, 2016: Cancer Research
https://www.readbyqxmd.com/read/27871640/multidimensional-influences-on-autism-symptom%C3%A2-measures-implications-for-use-in%C3%A2-etiological-research
#9
Karoline Alexandra Havdahl, Vanessa Hus Bal, Marisela Huerta, Andrew Pickles, Anne-Siri Øyen, Camilla Stoltenberg, Catherine Lord, Somer L Bishop
OBJECTIVE: Growing awareness that symptoms of autism spectrum disorder (ASD) transcend multiple diagnostic categories, and major advances in the identification of genetic syndromes associated with ASD, have led to widespread use of ASD symptom measures in etiologic studies of neurodevelopmental disorders. Insufficient consideration of potentially confounding factors such as cognitive ability or behavior problems can have important negative consequences in interpretation of findings, including erroneous estimation of associations between ASD and etiologic factors...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27868392/cerebellar-gray-matter-differentiates-children-with-early-language-delay-in-autism
#10
Anila M D'Mello, Dorothea M Moore, Deana Crocetti, Stewart H Mostofsky, Catherine J Stoodley
Early language delay (ELD) is one of the earliest indicators of autism spectrum disorder (ASD), and predicts later cognitive and behavioral outcomes. We aimed to determine the neural correlates of ELD in autism, and examine the relationships between gray matter (GM), age of first word/phrase, and core ASD symptoms. We used voxel-based morphometry to examine whole-brain differences in GM in 8-13 year old children with autism (n = 13 ELD; n = 22 non-ELD) and 35 age-matched typically developing (TD) children...
November 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27865066/newly-synthesized-camp-is-integrated-at-a-membrane-protein-complex-signalosome-to-ensure-receptor-response-specificity
#11
Raquel Guinzberg, Antonio Díaz-Cruz, Carlos Acosta-Trujillo, María Magdalena Vilchis-Landeros, Héctor Vázquez-Meza, Carlos Lozano-Flores, Natalia Chiquete-Felix, Alfredo Varela-Echavarría, Salvador Uribe-Carvajal, Héctor Riveros-Rosas, Enrique Piña
Spatiotemporal regulation of cAMP within the cell is required to achieve receptor-specific responses. The mechanism through which the cell selects a specific response to new synthesized cAMP is not fully understood. In hepatocyte plasma membranes, we identified two functional and independent cAMP-responsive signaling protein macrocomplexes that produce, use, degrade, and regulate their own non-diffusible (sequestered) cAMP pool to achieve their specific responses. Each complex responds to the stimulation of an adenosine G-protein coupled receptor (Ado-GPCR), bound to either A2A or A2B , but not simultaneously to both...
November 19, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27862909/single-center-experience-in-percutaneous-closure-of-arterial-duct-with-amplatzer-duct-occluder-ii-additional-sizes
#12
Heba Talat Mahmoud, Giuseppe Santoro, Gianpiero Gaio, Fabio Angelo D'Aiello, Cristina Capogrosso, Maria Teresa Palladino, Maria Giovanna Russo
OBJECTIVES: This study aimed to report a large, single-center experience of percutaneous arterial duct (AD) closure using Amplatzer Duct Occluder II Additional Sizes device (ADO II-AS)(St. Jude Medical Corp, St. Paul, MN, USA). BACKGROUND: Transcatheter closure of AD remains challenging in low body weight patients and those who have a persisting shunt following a previous attempt at interventional closure. Recent technical advances in device design may address these issues...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27854455/much-ado-about-nothing-capturing-attention-toward-locations-without-new-perceptual-events
#13
Matthew D Hilchey, J Eric T Taylor, Jay Pratt
Popular frameworks of attention propose that visual orienting occurs through a combination of bottom-up (stimulus-driven) and top-down (goal-directed) processes. Much of the basic research on these processes adheres paradigmatically to experimental methods that introduce salient but task-irrelevant stimuli (objects or transients) to the visual environment to determine whether attention is captured to their locations. This common practice of changing or adding a stimulus to a location to determine whether it captures attention reflects a notion that locations at which new features or stimuli spontaneously appear are prioritized above all else...
December 2016: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/27848051/continuity-and-change-in-cognition-and-autism-severity-from-toddlerhood-to-school-age
#14
Megan L E Clark, Josephine Barbaro, Cheryl Dissanayake
: This paper charted the cognitive and behavioural profiles from toddlerhood to middle childhood in 48 children diagnosed with ASD at 24-months. The Mullen Scales of Early Learning (MSEL) was administered at 24- and 48-months and the Wechsler Abbreviated Scale of Intelligence (WASI) at school age. Autism severity was derived using The Autism Diagnostic Observation Schedule (ADOS) Results: Developmental Disability/Intellectual Disability (DD/ID; Developmental Quotient <70) reduced from 64% at 24-months to 8% at outcome...
November 15, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27845531/much-ado-about-grit-a-meta-analytic-synthesis-of-the-grit-literature
#15
Marcus Credé, Michael C Tynan, Peter D Harms
Grit has been presented as a higher order personality trait that is highly predictive of both success and performance and distinct from other traits such as conscientiousness. This paper provides a meta-analytic review of the grit literature with a particular focus on the structure of grit and the relation between grit and performance, retention, conscientiousness, cognitive ability, and demographic variables. Our results based on 584 effect sizes from 88 independent samples representing 66,807 individuals indicate that the higher order structure of grit is not confirmed, that grit is only moderately correlated with performance and retention, and that grit is very strongly correlated with conscientiousness...
June 16, 2016: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/27843957/whether-her2-positive-non-breast-cancers-are-candidates-for-treatment-with-ado-trastuzumab-emtansine
#16
REVIEW
Azadeh Moghaddas, Ali Borhani
The National Comprehensive Cancer Network (NCCN) has recommended Ado-trastuzumab emtansine (T-DM1) as a preferred agent for patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer and prior trastuzumab therapy. Overexpression of HER2 was reported in other cancer types such as bladder, gastric and urogenital carcinosarcomas similar to what is discovered in breast cancer. Some preclinical studies demonstrated the potential anti-tumor effects of T-DM1 in HER2-positive non-breast cancers...
October 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/27842974/-a-longitudinal-3%C3%A2-years-study-of-the-development-of-four-children-with-autism-without-mental-retardation-after-90%C3%A2-sessions-of-social-skills-training
#17
M Liratni, C Blanchet, R Pry
INTRODUCTION: Few studies on social skills training essentially based on ABA techniques are dedicated to children with autism aged 5 to 10 years whereas autistic disorders can be diagnosed in very early childhood. Generally, the main criticisms about these social skills training are: shortness of programs (around 20 sessions), no manual with precise descriptions of sessions and used techniques, and a lack of generalization of the learned skills in everyday life. OBJECTIVES: To describe the evolution (before/after) of symptoms and sociocommunicative skills of 7 children with autism and no mental retardation (mean age=7...
November 11, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27835945/external-validation-of-multidimensional-prognostic-indices-ado-bodex-and-dose-in-a-primary-care-international-cohort-proepoc-copd-cohort
#18
Maite Espantoso-Romero, Miguel Román Rodríguez, Ana Duarte-Pérez, Jaime Gonzálvez-Rey, Pedro A Callejas-Cabanillas, Durdica Kasuba Lazic, Berta Anta-Agudo, Pere Torán Monserrat, Rosa Magallon-Botaya, Biljana Gerasimovska Kitanovska, Heidrun Lingner, Radost S Assenova, Claudia Iftode, Francisco Gude-Sampedro, Ana Clavería
BACKGROUND: Due to the heterogeneous and systemic nature of the chronic obstructive pulmonary disease (COPD), the new guidelines are oriented toward individualized attention. Multidimensional scales could facilitate its proper clinical and prognostic assessment, but not all of them were validated in an international primary care cohort, different from the original ones used for model development. Therefore, our main aim is to assess the prognostic capacity of the ADO, BODEx and DOSE indices in primary care for predicting mortality in COPD patients and to validate the models obtained in subgroups of patients, classified by revised Global Initiative for Chronic Obstructive Lung Disease (2011) and updated Spanish Guideline (2014)...
November 11, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27822307/comparison-of-aldehyde-producing-activities-of-cyanobacterial-acyl-acyl-carrier-protein-reductases
#19
Hisashi Kudo, Ryota Nawa, Yuuki Hayashi, Munehito Arai
BACKGROUND: Biosynthesis of alkanes is an attractive way of producing substitutes for petroleum-based alkanes. Acyl-[acyl carrier protein (ACP)] reductase (AAR) is a key enzyme for alkane biosynthesis in cyanobacteria and catalyzes the reduction of fatty acyl-ACP to fatty aldehydes, which are then converted into alkanes/alkenes by aldehyde-deformylating oxygenase (ADO). The amino acid sequences of AARs vary among cyanobacteria. However, their differences in catalytic activity, substrate specificity, and solubility are poorly understood...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27811450/gestational-age-at-initiation-of-antenatal-care-in-a-tertiary-hospital-southwestern-nigeria
#20
O P Aduloju, A A Akintayo, I P Ade-Ojo, J O Awoleke, T Aduloju, O R Ogundare
CONTEXT: Antenatal care utilization has been shown to be associated with reduction in maternal and perinatal morbidity and mortality while early initiation provides an opportunity for optimum utilization of this care with improved maternal and fetal outcomes. AIM: This study seeks to determine the time of initiation of antenatal care among pregnant women and possible factors influencing such timing. SETTING: A cross-sectional study involving 530 pregnant women was carried out at the booking clinic of the Ekiti State University Teaching Hospital, Ado-Ekiti, between September 03, 2013, and March 04, 2014...
November 2016: Nigerian Journal of Clinical Practice
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