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https://www.readbyqxmd.com/read/29119215/surgical-ligation-versus-percutaneous-closure-of-patent-ductus-arteriosus-in-very-low-weight-preterm-infants-which-are-the-real-benefits-of-the-percutaneous-approach
#1
A Rodríguez Ogando, I Planelles Asensio, A Rodríguez Sánchez de la Blanca, F Ballesteros Tejerizo, M Sánchez Luna, J M Gil Jaurena, C Medrano López, J L Zunzunegui Martínez
Percutaneous treatment of patent ductus arteriosus (PDA) in extreme premature infants is technically difficult, and therefore, often not consider as an alternative to surgery. The main objective of our work was to compare respiratory status prior and post ductal closure and morbi-mortality, in our series of preterm infants with percutaneous PDA closure versus surgical ligation in the same time-period. Retrospective review of all premature infants submitted to percutaneous and surgical PDA closure from January 2011 to December 2016...
November 8, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29090071/a-novel-mutation-in-snx10-gene-causes-malignant-infantile-osteopetrosis
#2
Akbar Amirfiroozy, Amir A Hamidieh, Zahra Golchehre, Azim Rezamand, Mahin Yahyaei, Fatemeh Beiranvandi, Soheyla Amirfiroozy, Mohammad Keramatipour
BACKGROUND: Osteopetrosis is a group of genetically heterogonous diseases and the main feature of that is increased bone density due to osteoclast's abnormality. It has three clinical forms based on inheritance pattern, severity and age of onset: the dominant benign form (ADO), the intermediate form (IRO) and the recessive severe form (ARO). One of the recently discovered genes for ARO form is SNX10 that accounts for 4% of affected persons by this type. METHODS: In this paper, a 15 years old girl affected by osteopetrosis has been analyzed for detecting causal mutation in known osteopetrosis genes...
October 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29089740/awareness-and-use-of-surgical-checklist-among-theatre-users-at-ekiti-state-university-teaching-hospital-ado-ekiti-nigeria
#3
Johnson Dare Ogunlusi, Moruf Babatunde Yusuf, Popoola Sunday Ogunsuyi, Obafemi K Wuraola, Waheed O Babalola, Kehinde Sunday Oluwadiya, Oduwole Olayemi Ajogbasile
BACKGROUND: Surgical checklist was introduced by the World Health Organization to reduce the number of surgical deaths and complications. During a surgical conference on "safety in surgical practice," it was noticed that the awareness and the use of surgical checklist are poor in Nigerian hospitals. This study was aimed at determining the awareness and use of surgical checklist among the theater users in our hospital, factors militating against its implementation, and make recommendations...
July 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29082907/self-discharge-against-medical-advice-from-tertiary-health-institution-a-call-for-concern
#4
Moruf Babatunde Yusuf, Johnson Dare Ogunlusi, Sunday Ogunsuyi Popoola, Sheriff Olawale Ogunlayi, Waheed Olaide Babalola, Kehinde Sunday Oluwadiya
BACKGROUND: Self-discharge by patients without completing their treatment is a problematic issue in healthcare and is strongly associated with readmission and poor treatment outcome. PATIENTS AND METHODS: A descriptive study of the rate and reasons why patients with limb injuries took self-discharge against medical advice (DAMA) from our facility, Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria, a tertiary health institution between May 2011 and April 2014...
July 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29076255/what-will-my-child-s-future-hold-phenotypes-of-intellectual-development-in-2-8-year-olds-with-autism-spectrum-disorder
#5
Marjorie Solomon, Ana-Maria Iosif, Vanessa P Reinhardt, Lauren E Libero, Christine W Nordahl, Sally Ozonoff, Sally J Rogers, David G Amaral
We examined phenotypes of autism spectrum disorder (ASD) based on trajectories of intellectual development from early (ages 2-3 ½) to middle (ages 5-8) childhood in a recent clinically ascertained cohort. Participants included 102 children (82 males) initially diagnosed with ASD from the Autism Phenome Project longitudinal sample. Latent class growth analysis was used to identify distinct IQ trajectories. Baseline and developmental course differences among groups were assessed using univariate techniques and repeated measures regression models, respectively...
October 27, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29063276/the-infamous-famous-sulfonylureas-and-cardiovascular-safety-much-ado-about-nothing
#6
REVIEW
Laurentiu M Pop, Ildiko Lingvay
PURPOSE OF REVIEW: Sulfonylureas (SUs) are one of the most commonly used glucose-lowering agents worldwide. While their efficacy is undisputed, their cardiovascular safety has been debated since the 1970's. RECENT FINDINGS: With no dedicated cardiovascular studies to definitively answer this question, observational studies and meta-analyses abound and have reported divergent results, fueling the controversy. Studies that compared SUs to metformin or newer agents, like GLP-1 agonists and SGLT2 inhibitors, suggest a difference in cardiovascular events, yet this is likely the result of beneficial effects of the latter...
October 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/29061222/international-multicentre-randomised-controlled-trial-of-improvisational-music-therapy-for-children-with-autism-spectrum-disorder-time-a-study
#7
Mike J Crawford, Christian Gold, Helen Odell-Miller, Lavanya Thana, Sarah Faber, Jörg Assmus, Łucja Bieleninik, Monika Geretsegger, Claire Grant, Anna Maratos, Stephan Sandford, Amy Claringbold, Helen McConachie, Morag Maskey, Karin Antonia Mössler, Paul Ramchandani, Angela Hassiotis
BACKGROUND: Preliminary studies have indicated that music therapy may benefit children with autism spectrum disorders (ASD). OBJECTIVES: To examine the effects of improvisational music therapy (IMT) on social affect and responsiveness of children with ASD. DESIGN: International, multicentre, three-arm, single-masked randomised controlled trial, including a National Institute for Health Research (NIHR)-funded centre that recruited in London and the east of England...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29058940/much-ado-about-aha-insight-problem-solving-is-strongly-related-to-working-memory-capacity-and-reasoning-ability
#8
Adam Chuderski, Jan Jastrzębski
A battery comprising 4 fluid reasoning tests as well as 13 working memory (WM) tasks that involved storage, recall, updating, binding, and executive control, was applied to 318 adults in order to evaluate the true relationship of reasoning ability and WM capacity (WMC) to insight problem solving, measured using 40 verbal, spatial, math, matchstick, and remote associates problems (insight problems). WMC predicted 51.8% of variance in insight problem solving and virtually explained its almost isomorphic link to reasoning ability (84...
October 23, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/29050491/some-antidiabetic-medicinal-plants-used-by-traditional-healers-in-ado-ekiti-nigeria
#9
F C Akharaiyi, A J Akinyemi, C C Isitua, O T Ogunmefun, S O Opakunle, J K Fasae
OBJECTIVES: The work described plants collection, preparation and administration for diabetes cure in Ado Ekiti in Nigeria. METHODS: Twenty three plant samples were identified for the use in the treatment of diabetes by the herbalists. The plants that are common among the healers are Anthocleista djalonensis, Vernonia amygdalina, Ocimum gratissimum, Momordica charantia. RESULTS: The most preferred method of preparation by the healers is concoction and decoction of fresh leaves, stem bark and roots...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29043411/population-pharmacokinetics-of-trastuzumab-emtansine-in-previously-treated-patients-with-her2-positive-advanced-gastric-cancer-agc
#10
Shang-Chiung Chen, Matts Kagedal, Yuying Gao, Bei Wang, Marie-Laurence Harle-Yge, Sandhya Girish, Jin Jin, Chunze Li
PURPOSE: Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate comprising trastuzumab conjugated via a stable thioether linker to DM1, a highly potent cytotoxic agent. A population pharmacokinetics (PK) analysis was performed to characterize T-DM1 PK and evaluate the impact of patient characteristics on T-DM1 PK in previously treated patients with HER2-positive advanced gastric cancer (AGC). METHODS: Following T-DM1 weekly or every three weeks dosing, T-DM1 concentration measurements (n = 780) were collected from 136 patients in the GATSBY (NCT01641939) study and analyzed using nonlinear mixed effects modeling...
October 17, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29038055/serum-and-brain-purine-levels-in-an-experimental-systemic-infection-of-mice-by-cryptococcus-neoformans-purinergic-immunomodulatory-effects
#11
Maria Isabel de Azevedo, Aleksandro S Da Silva, Laerte Ferreiro, Pedro H Doleski, Alexandre A Tonin, Emerson A Casali, Cesar E J Moritz, Gabriel H Schirmbeck, Valesca V Cardoso, Mariana M Flores, Rafael Fighera, Janio M Santurio
The aim of this study was to evaluate the purine levels in serum and brains of mice experimentally infected by Cryptococcus neoformans. Twenty-four mice were divided into the following groups: a control group (n = 12; Group A) and an infection group with animals that were infected (n = 12; Group B) with a 0.3-mL intraperitoneal injection containing 1.7 × 10(7)C. neoformans cells. Blood and brains were collected on days 20 (n = 6 per group) and 50 (n = 6 per group) post-infection (PI). Histopathology and lung and brain cultures were performed to confirm fungal infection and tissue injuries...
October 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29031691/understanding-vaccine-hesitancy-in-polio-eradication-in-northern-nigeria
#12
Sebastian Taylor, Mahmud Khan, Ado Muhammad, Okey Akpala, Marit van Strien, Chris Morry, Warren Feek, Ellyn Ogden
BACKGROUND: Vaccine hesitancy constitutes a major threat to the Global Polio Eradication Initiative (GPEI), and to further expansion of routine immunisation. Understanding hesitancy, leading in some cases to refusal, is vital to the success of GPEI. Re-emergence of circulating wild poliovirus in northern Nigeria in mid-2016, after 24months polio-free, gives urgency to this. But it is equally important to protect and sustain the global gains available through routine immunisation in a time of rising scepticism and potential rejection of specific vaccines or immunisation more generally...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/29027691/serum-adenosine-deaminase-and-xanthine-oxidase-activities-in-silver-catfish-naturally-infected-with-ichthyophthirius-multifiliis-the-influence-of-these-enzymes-on-inflammatory-and-oxidative-status
#13
M D Baldissera, C F Souza, P H Doleski, S G Monteiro, A S da Silva, B Baldisserotto
Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals...
October 13, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29018903/clinical-significance-of-dxa-and-hr-pqct-in-autosomal-dominant-osteopetrosis-ado-ii
#14
Sebastian Butscheidt, Tim Rolvien, Uwe Kornak, Felix N Schmidt, Thorsten Schinke, Michael Amling, Ralf Oheim
The main hallmark of high bone mass (HBM) disorders is increased bone mineral density, potentially visible in conventional radiographs and quantifiable by other radiographic methods. While one of the most common forms of HBM is CLCN7-related autosomal dominant osteopetrosis type II (ADO II), there is no consensus on diagnostic thresholds. We therefore wanted to assess whether CLCN7-osteopetrosis patients differ from benign HBM cases in terms of (1) bone mineral density, (2) bone structure, and (3) microarchitectural abnormalities...
October 10, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29018099/feedback-control-in-hemodialysis-much-ado-about-nothing
#15
EDITORIAL
Manfred Hecking, Daniel Schneditz
No abstract text is available yet for this article.
November 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28988061/nanolayered-hybrid-mediates-synergistic-co-delivery-of-ligand-and-ligation-activator-for-inducing-stem-cell-differentiation-and-tissue-healing
#16
Heemin Kang, Minkyu Kim, Qian Feng, Sien Lin, Kongchang Wei, Rui Li, Chan Ju Choi, Tae-Hyun Kim, Gang Li, Jae-Min Oh, Liming Bian
Cellular behaviors, such as differentiation, are regulated by complex ligation processes involving cell surface receptors, which can be activated by various divalent metal cations. The design of nanoparticle for co-delivery of ligand and ligation activator can offer a novel strategy to synergistically stimulate ligation processes in vivo. Here, we present a novel layered double hydroxide (LDH)-based nanohybrid (MgFe-Ado-LDH), composed of layered MgFe hydroxide nanocarriers sandwiching the adenosine cargo molecule, maintained through an electrostatic balance, to co-deliver the adenosine (Ado) ligand from the interlayer spacing and the Mg(2+) ion (ligation activator) through the dissolution of the MgFe nanocarrier itself...
September 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28978201/protein-hydration-dynamics-much-ado-about-nothing
#17
Sayantan Mondal, Saumyak Mukherjee, Biman Bagchi
No abstract text is available yet for this article.
October 5, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28969087/efficacy-and-safety-of-t-dm1-in-the-common-practice-of-her2-advanced-breast-cancer-setting-a-multicenter-study
#18
Alessandra Fabi, Michelino De Laurentiis, Michele Caruso, Enrichetta Valle, Luca Moscetti, Daniele Santini, Katia Cannita, Luisa Carbognin, Mariangela Ciccarese, Rosalba Rossello, Grazia Arpino, Vita Leonardi, Filippo Montemurro, Nicla La Verde, Daniele Generali, Alberto Zambelli, Giuseppa Scandurra, Michelangelo Russillo, Ida Paris, Anna Maria D'Ottavio, Gianfranco Filippelli, Marianna Giampaglia, Simonetta Stani, Agnese Fabbri, Daniele Alesini, Daniela Cianniello, Diana Giannarelli, Francesco Cognetti
Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive, metastatic breast cancer (mBC). The aim of this 'field-practice' study was to investigate the efficacy and safety of T-DM1, focusing on treatment line, previous lapatinib treatment and patterns of metastasis. Three hundred and three patients with HER2-positive mBC who received T-DM1 were identified by reviewing the medical records of 24 Italian Institutions...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968847/multidimensional-neuroanatomical-subtyping-of-autism-spectrum-disorder
#19
Seok-Jun Hong, Sofie L Valk, Adriana Di Martino, Michael P Milham, Boris C Bernhardt
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with multiple biological etiologies and highly variable symptoms. Using a novel analytical framework that integrates cortex-wide MRI markers of vertical (i.e., thickness, tissue contrast) and horizontal (i.e., surface area, geodesic distance) cortical organization, we could show that a large multi-centric cohort of individuals with ASD falls into 3 distinctive anatomical subtypes (ASD-I: cortical thickening, increased surface area, tissue blurring; ASD-II: cortical thinning, decreased distance; ASD-III: increased distance)...
September 14, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28967894/inner-and-outer-wall-sorting-of-double-walled-carbon-nanotubes
#20
Han Li, Georgy Gordeev, Sören Wasserroth, Venkata Sai Kiran Chakravadhanula, Shyam Kumar Chethala Neelakandhan, Frank Hennrich, Ado Jorio, Stephanie Reich, Ralph Krupke, Benjamin Scott Flavel
Double-walled carbon nanotubes (DWCNTs) consist of two coaxially aligned single-walled carbon nanotubes (SWCNTs), and previous sorting methods only achieved outer-wall electronic-type selectivity. Here, a separation technique capable of sorting DWCNTs by semiconducting (S) or metallic (M) inner- and outer-wall electronic type is presented. Electronic coupling between the inner and outer wall is used to alter the surfactant coating around each of the DWCNT types, and aqueous gel permeation is used to separate them...
October 2, 2017: Nature Nanotechnology
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