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https://www.readbyqxmd.com/read/29776993/tumor-immune-evasion-arises-through-loss-of-tnf-sensitivity
#1
Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro
Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of resistance remain poorly defined. We used a series of whole-genome clustered regularly interspaced short palindromic repeat (CRISPR)-based screens performed in vitro and in vivo to identify mechanisms of tumor immune evasion from cytotoxic lymphocytes [CD8+ T cells and natural killer (NK) cells]. Deletion of key genes within the tumor necrosis factor (TNF) signaling, interferon-γ (IFN-γ) signaling, and antigen presentation pathways provided protection of tumor cells from CD8+ T cell-mediated killing and blunted antitumor immune responses in vivo...
May 18, 2018: Science Immunology
https://www.readbyqxmd.com/read/29769837/the-role-of-extracellular-adenosine-generation-in-the-development-of-autoimmune-diseases
#2
REVIEW
F Morandi, A L Horenstein, R Rizzo, F Malavasi
Adenosine (ADO) is an immunosuppressive molecule, which suppresses the immune responses by interacting with specific receptors expressed by immune effector cells. ADO is produced from ATP through the enzymatic activities of CD39 and CD73. Alternatively, ADO can be generated starting from NAD+ , which is metabolized by the concerted action of CD38, CD203a/PC-1, and CD73. The role of ADO in immunity has been characterized in the last years in physiology and in pathological settings. This review examines a panel of reports focused on the functions of ADO in the context of human autoimmune/inflammatory diseases and the selected animal models...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29764212/the-clinical-application-of-single-sperm-based-snp-haplotyping-for-pgd-of-osteogenesis-imperfecta
#3
Linjun Chen, Zhenyu Diao, Zhipeng Xu, Jianjun Zhou, Guijun Yan, Haixiang Sun
Osteogenesis imperfecta (OI) is a genetically heterogeneous disorder, presenting either autosomal dominant, autosomal recessive or X-linked inheritance patterns. The majority of OI cases are autosomal dominant and are caused by heterozygous mutations in either the COL1A1 or COL1A2 gene. In these dominant disorders, allele dropout (ADO) can lead to misdiagnosis in preimplantation genetic diagnosis (PGD). Polymorphic markers linked to the mutated genes have been used to establish haplotypes for identifying ADO and ensuring the accuracy of PGD...
May 15, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29763840/the-risk-of-neurodevelopmental-disorders-at-age-10-years-associated-with-blood-concentrations-of-interleukins-4-and-10-during-the-first-postnatal-month-of-children-born-extremely-preterm
#4
Alan Leviton, Robert M Joseph, Elizabeth N Allred, Raina N Fichorova, T Michael O'Shea, Karl K C Kuban, Olaf Dammann
BACKGROUND: Interleukin (IL)-4 and IL-10 are viewed mainly as anti-inflammatory cytokines. Yet, high concentrations have also been associated with inflammation-related diseases in newborns. METHODS: We measured the concentrations of IL-4 and IL-10, as well as IL-8 and ICAM-1 in blood specimens collected on postnatal day 21 (N = 555), day 28 (N = 521), and both days 21 and 28 (N = 449) from children born extremely preterm (EP) (<28 weeks gestation) who at age 10 years had a DAS-II IQ Z-score > -2 (which approximates a score of >70) and the following assessments, CCC-2, and CSI-4, DAS-II, NEPSY-II, OWLS-II, SCQ, and WIAT-III...
May 12, 2018: Cytokine
https://www.readbyqxmd.com/read/29759563/targeting-the-tumor-promoting-effects-of-adenosine-in-chronic-lymphocytic-leukemia
#5
REVIEW
Yiqing Cai, Lili Feng, Xin Wang
Chronic lymphocytic leukemia (CLL) is a hematological malignancy which is characterized by progressive accumulation of functionally deficient B cells in blood, bone marrow, and lymphatic tissue. The tumor microenvironment (TME) appears to play a critical role in genesis and progression of CLL. High levels of extracellular adenosine (ADO) are detected in CLL as a consequence of expression of ecto-enzymes, such as CD39 and CD73. Extracellular ADO exhibits a broad range of effects on cell cycle control, immunoregulation, angiogenesis and cytokine regulation through both direct and indirect mechanisms...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29752763/cofactor-biogenesis-in-cysteamine-dioxygenase-c-f-bond-cleavage-with-genetically-incorporated-unnatural-tyrosine
#6
Yifan Wang, Wendell P Griffith, Jiasong Li, Teruaki Koto, Daniel J Wherritt, Elizabe Fritz, Aimin Liu
Cysteamine dioxygenase (ADO) is a thiol dioxygenase whose study has been stagnated by ambiguity as to whether or not it possesses an anticipated protein-derived cofactor. Herein, we report the discovery and elucidation of a Cys-Tyr cofactor in human ADO, crosslinked between Cys220 and Tyr222 through a thioether (C-S) bond. By genetically incorporating an unnatural amino acid 3,5-difluoro-tyrosine (F2-Tyr) specifically into Tyr222 of human ADO, we identified an autocatalytic oxidative carbon-fluorine bond activation and fluoride release by mass spectrometry and 19F NMR spectroscopy...
May 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29746746/prevalence-of-anemia-and-consumption-of-iron-rich-food-groups-in-mexican-children-and-adolescents-ensanut-mc-2016
#7
Vanessa De la Cruz-Góngora, Salvador Villalpando, Teresa Shamah-Levy
OBJECTIVE: To describe the prevalence of anemia and con-sumption of iron rich groups among Mexican children and adolescents who participated in the Halfway National Health and Nutrition Survey, 2016. MATERIALS AND METHODS: Our study sample included children and adolescents who provided full capillary hemoglobin data. Anemia was defined accord-ing to WHO criteria. Logistic regression models were used to explore the association among consumption of iron-rich food groups, sociodemographic characteristics and anemia...
May 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29745774/modulatory-role-of-rutin-on-2-5-hexanedione-induced-chromosomal-and-dna-damage-in-rats-validation-of-computational-predictions
#8
Aliyu Muhammad, David Ebuka Arthur, Sanusi Babangida, Ochuko L Erukainure, Ibrahim Malami, Hadiza Sani, Aliyu Waziri Abdulhamid, Idayat Omoyemi Ajiboye, Ahmed Ariyo Saka, Nafisa Muhammed Hamza, Suleiman Asema, Zaharaddeen Muhammad Ado, Taibat Ishaq Musa
The aim of this study was to evaluate the potentials of rutin on 2,5-hexanedione-induced toxicities. Two successive phases were involved using in silico and in vivo approaches. The in silico was adopted for potential oral toxicity and docking. The in vivo was carried-out in two stages for two weeks; the ameliorative (stage 1, first week), preventive, and curative studies (stage 2, extended to second week). In stage 1, rats were divided into four groups of seven each (distilled water, 3% (v/v) 2,5-hexanedione, 10 mg/kg rutin, and co-administration)...
May 10, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29741525/orbita-much-ado-about-nothing
#9
A G Zaman
No abstract text is available yet for this article.
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29731713/cytokine-induced-killer-cells-express-cd39-cd38-cd203a-cd73-ectoenzymes-and-p1-adenosinergic-receptors
#10
Alberto L Horenstein, Antonella Chillemi, Roberta Zini, Valeria Quarona, Nicoletta Bianchi, Rossella Manfredini, Roberto Gambari, Fabio Malavasi, Davide Ferrari
Cytokine-induced killer (CIK) cells, a heterogeneous T cell population obtained by in vitro differentiation of peripheral blood mononuclear cells (PBMC), represent a promising immunological approach in cancer. Numerous studies have explored the role of CD38, CD39, CD203a/PC-1, and CD73 in generating extracellular adenosine (ADO) and thus in shaping the tumor niche in favor of proliferation. The findings shown here reveal that CIK cells are able to produce extracellular ADO via traditional (CD39/CD73) and/or alternative (CD38/CD203a/CD73 or CD203a/CD73) pathways...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29726941/hiv-and-cardiovascular-disease-much-ado-about-nothing
#11
Gary S Ma, Bruno R Cotter
No abstract text is available yet for this article.
May 3, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29724388/external-validation-of-ado-dose-cote-and-codex-at-predicting-death-in-primary-care-patients-with-copd-using-standard-and-machine-learning-approaches
#12
Daniel R Morales, Rob Flynn, Jianguo Zhang, Emmanuel Trucco, Jennifer K Quint, Kris Zutis
BACKGROUND: Several models for predicting the risk of death in people with chronic obstructive pulmonary disease (COPD) exist but have not undergone large scale validation in primary care. The objective of this study was to externally validate these models using statistical and machine learning approaches. METHODS: We used a primary care COPD cohort identified using data from the UK Clinical Practice Research Datalink. Age-standardised mortality rates were calculated for the population by gender and discrimination of ADO (age, dyspnoea, airflow obstruction), COTE (COPD-specific comorbidity test), DOSE (dyspnoea, airflow obstruction, smoking, exacerbations) and CODEX (comorbidity, dyspnoea, airflow obstruction, exacerbations) at predicting death over 1-3 years measured using logistic regression and a support vector machine learning (SVM) method of analysis...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29719709/chemical-synthesis-of-membrane-proteins-a-model-study-on-the-influenza-virus-b-proton-channel
#13
A C Baumruck, D Tietze, L K Steinacker, A A Tietze
In the present study we have developed and optimized a robust strategy for the synthesis of highly hydrophobic peptides, especially membrane proteins, exemplarily using the influenza B M2 proton channel (BM2(1-51)). This strategy is based on the native chemical ligation of two fragments, where the thioester fragment is formed from an oxo-ester peptide, which is synthesized using Fmoc-SPPS, and features an in situ cleavable solubilizing tag (ADO, ADO2 or ADO-Lys5 ). The nearly quantitative production of the ligation product was followed by an optimized work up protocol, resulting in almost quantitative desulfurization and Acm-group cleavage...
February 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29717196/eeg-analytics-for-early-detection-of-autism-spectrum-disorder-a-data-driven-approach
#14
William J Bosl, Helen Tager-Flusberg, Charles A Nelson
Autism spectrum disorder (ASD) is a complex and heterogeneous disorder, diagnosed on the basis of behavioral symptoms during the second year of life or later. Finding scalable biomarkers for early detection is challenging because of the variability in presentation of the disorder and the need for simple measurements that could be implemented routinely during well-baby checkups. EEG is a relatively easy-to-use, low cost brain measurement tool that is being increasingly explored as a potential clinical tool for monitoring atypical brain development...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29716712/contemporary-outcomes-of-percutaneous-closure-of-patent-ductus-arteriosus-in-adolescents-and-adults
#15
Sudhakar P, John Jose, Oommen K George
BACKGROUND: Catheter based treatment has gained wide acceptance for management of patent ductus arteriosus (PDA) ever since its introduction. Percutaneous closure in adults can be challenging because of anatomical factors including large sizes, associated pulmonary arterial hypertension (PAH) and co-morbidities. This study aimed to provide comprehensive contemporary data on the safety and efficacy of percutaneous device closure of PDA in adult and adolescent population at a large referral center...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29713257/measuring-individual-performance-with-comprehensive-bibliometric-reports-as-an-alternative-to-h-index-values
#16
Lutz Bornmann, Robin Haunschild
The h -index is frequently used to measure the performance of single scientists in Korea (and beyond). No single indicator alone, however, is able to provide a stable and complete assessment of performance. The Stata command bibrep.ado is introduced which automatically produces bibliometric reports for single researchers (senior researchers working in the natural or life sciences). The user of the command receives a comprehensive bibliometric report which can be used in research evaluation instead of the h -index...
April 30, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29707375/transcatheter-closure-of-a-large-patent-ductus-arteriosus-using-jugular-access-in-an-infant
#17
Precylia Fernandes, Anass Assaidi, Alban-Elouen Baruteau, Alain Fraisse
Trans-catheter device closure of patent ductus arteriosus (PDA) via femoral route is the commonly used, safe and effective procedure. Trans-jugular approach has been successfully used in older children with interrupted inferior vena cava. We report a case of successful occlusion of PDA using Amplatzer duct occluder (ADO) via trans-jugular approach following difficulties encountered in gaining femoral venous access. A 6-month-old male infant, weighing 8 kg was admitted for percutaneous catheter closure of PDA...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29705814/serum-cytokine-and-growth-factor-levels-in-children-with-autism-spectrum-disorder
#18
Ivo Lochman, Veronika Švachová, Kristýna Mílková Pavlíková, Hana Medřická, Vilém Novák, Lenka Trilecová, Lubomír Pavliska, Václav Procházka
BACKGROUND The immune system may have a role in the pathogenesis of autism spectrum disorder (ASD), including typical and atypical autism. The aim of this study was to determine whether a cytokine and growth factor panel could be identified for the diagnosis and prognosis in children with ASD, including typical and atypical autism. MATERIAL AND METHODS This study included 26 children with ASD (typical or atypical) and 11 of their siblings who did not have ASD. A panel of ten serum cytokines and growth factors were investigated using addressable laser bead assay (ALBIA) and enzyme-linked immunosorbent assay (ELISA) kits...
April 29, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29696527/prevalence-and-characteristics-of-autism-spectrum-disorder-among-spanish-school-age-children
#19
Paula Morales-Hidalgo, Joana Roigé-Castellví, Carmen Hernández-Martínez, Núria Voltas, Josefa Canals
The present study aims to assess the prevalence of autism spectrum disorder (ASD) in preschool and school-age children following a two-phase procedure. The screening phase was performed on a sample of 5555 children taking into account parent and teacher information. The individual assessment included the ADI-R, ADOS-2 and Wechsler scales. The estimated prevalence was 1.55% in preschoolers and 1.00% in school-age children. Between 1.84 and 2.59% of the children exhibited subclinical diagnosis. The male-to-female ratio was around 4:1...
April 25, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29687370/performance-comparison-of-two-whole-genome-amplification-techniques-in-frame-of-multifactor-preimplantation-genetic-testing
#20
Ludmila Volozonoka, Dmitry Perminov, Liene Korņejeva, Baiba Alkšere, Natālija Novikova, Evija Jokste Pīmane, Arita Blumberga, Inga Kempa, Anna Miskova, Linda Gailīte, Violeta Fodina
PURPOSE: To compare multiple displacement amplification and OmniPlex whole genome amplification technique performance during array comparative genome hybridization (aCGH), Sanger sequencing, SNaPshot and fragment size analysis downstream applications in frame of multifactor embryo preimplantation genetic testing. METHODS: Preclinical workup included linked short tandem repeat (STR) marker selection and primer design for loci of interest. It was followed by a family haplotyping, after which an in vitro fertilization preimplantation genetic testing (IVF-PGT) cycle was carried out...
April 23, 2018: Journal of Assisted Reproduction and Genetics
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