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https://www.readbyqxmd.com/read/29329050/factors-influencing-the-severity-of-behavioral-phenotype-in-autism-spectrum-disorders-implications-for-research
#1
Mingyang Zou, Caihong Sun, Jia Wang, Jing Kang, Zhanbin Xu, Yongjuan Ma, Lei Chen, Xinxi Zhang, Wei Xia, Lijie Wu
The phenotypic heterogeneity of Autism Spectrum Disorders (ASD) presents particular research challenges in the assessment of symptom severity, while the standardized Autism Diagnostic Observation Schedule (ADOS) scores present a severity metric, namely calibrated severity scores (CSS) that are relatively impervious to individual characteristics. To date, no studies have examined the convergent validity of CSS in Chinese sample populations. The present study investigated the validity of the ADOS-CSS using a sample of 321 children aged 2-18 years with ASD, and developed upon existing literature examining the influence of non-ASD-specific characteristics on other types of measures including Autism Diagnostic Interview-Revised (ADI-R), Social Responsiveness Scale (SRS), and Vineland Adaptive Behavior Scales (VABS)...
January 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29322384/the-relationship-between-social-affect-and-restricted-and-repetitive-behaviors-measured-on-the-ados-2-and-maternal-stress
#2
Claire Schutte, Wendy Richardson, Morgan Devlin, Jeanna Hill, Maliki Ghossainy, Laura Hewitson
This study investigated categories of autism spectrum disorder (ASD) symptoms measured by the Autism Diagnostic Observation Schedule-Second Edition and their association with maternal stress. Social affect and restricted and repetitive behaviors were compared with levels of maternal stress, measured by the Parenting Stress Index, in 102 children with ASD ages 2-12 years of age. Results indicated that social affect and restricted and repetitive behaviors were associated with the mother's stress regarding acceptability of the child's condition...
January 10, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29320334/body-weight-and-bullying-victimization-among-us-adolescents
#3
Claudia Wang, Yin Li, Kaigang Li, Dong-Chul Seo
OBJECTIVE: We examined the association between body weight status at all levels (including underweight, normal weight, overweight, and obesity) and bullying victimization among US ado- lescents using a nationally representative data. METHODS: We used logistic regression to exam- ine the association between bullying victimization and body weight status by sex with the data from the 2013 Youth Risk Behavior Survey (YRBS) (N = 11,825), controlling for demographics, selected behavioral confounders, and complex survey design...
January 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29317482/night-diving-by-some-emperor-penguins-during-the-winter-breeding-period-at-cape-washington
#4
Gerald L Kooyman, Robert P van Dam, Luis A Hückstädt
All through the bird literature and feature films, there is much ado about dedicated emperor penguin males fasting for 115 days while they do all the incubation of the single egg. Sometimes, they may not fast for so long. Based on a winter visit to Cape Washington, we obtained evidence that some birds may feed before the egg is laid, and if they do, and some are males, then their fast is much less than 115 days. The consequence of a shorter fast for the male is a better chance of completing the 65 day incubation fast and success in fledging the chick...
January 9, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29307037/autism-spectrum-symptomatology-among-children-with-duplication-7q11-23-syndrome
#5
Bonita P Klein-Tasman, Carolyn B Mervis
Gold-standard diagnostic assessments of autism spectrum disorder (ASD) symptomatology were conducted on 63 children (mean CA: 8.81 years) with 7q11.23 duplication syndrome, one of the copy number variants identified by Sanders et al. (Neuron 70:863-885, 2011a) as associated with ASD. ASD classification rate was 39.6% for the Autism Diagnostic Interview-Revised and 25.4% for the Autism Diagnostic Observation Schedule-2 (ADOS-2). Based on these assessments combined with clinical judgment, 19.0% of children were diagnosed with ASD...
January 6, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29286557/enzymatic-electrosynthesis-of-alkanes-via-bioelectrocatalytic-decarbonylation-of-fatty-aldehydes
#6
Sofiene Abdellaoui, Florika Macazo, Rong Cai, Antonio de Lacey, Marcos Pita, Shelley Minteer
An enzymatic electrosynthesis system is created by combining an aldehyde deformylating oxygenase (ADO) from cyanobacteria catalyzing the decarbonylation of fatty aldehydes to alkanes plus formic acid with an electrochemical interface. This system is able to produce a range of alkanes (octane to propane) from aldehydes and alcohols. The combination of this bioelectrochemical system with a hydrogenase bioanode yields a H2/heptanal enzymatic fuel cell (EFC) able to simultaneously generate electrical energy with a maximum current density of 25 µA cm-2 at 0...
December 29, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29274310/is-bone-morphogenetic-protein-2-as-effective-as-alveolar-distraction-osteogenesis-for-vertical-bone-regeneration
#7
Jose M Reuss, Joan Pi-Anfruns, Peter K Moy
PURPOSE: The aim of this study was to assess the clinical effectiveness of alveolar distraction osteogenesis (ADO) versus recombinant human bone morphogenetic protein-2 (rh-BMP-2) for vertical ridge augmentation. Few data have been published on vertical bone regeneration using rh-BMP-2. MATERIALS AND METHODS: The authors implemented a retrospective cohort study and enrolled a sample composed of patients with deficient alveolar vertical bone height. The primary predictor variable was vertical augmentation with BMP-2 and a titanium mesh or ADO...
November 29, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29240514/menopausal-asthma-much-ado-about-nothing-an-observational-study
#8
Katarzyna Bialek-Gosk, Marta Maskey-Warzechowska, Rafal Krenke, Marta Dabrowska, Magdalena Paplinska-Goryca, Patrycja Nejman-Gryz, Joanna Domagala-Kulawik, Tadeusz Przybylowski, Ryszarda Chazan
OBJECTIVE: Menopausal asthma is considered a distinct asthma phenotype. Our aim was to identify potential specific features of asthma in postmenopausal women in a cohort of Polish females. METHODS: Asthma severity and control, pulmonary function, exhaled nitric oxide (FENO), peripheral blood and induced sputum (IS) differential cell count were compared in three groups: women with premenopausal asthma (group 1), menopausal women with pre-existing asthma (group 2A) and menopausal women with asthma onset in the perimenopausal or menopausal period (group 2B)...
December 14, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29239690/antibody-drug-conjugates-design-and-development-for-therapy-and-imaging-in-and-beyond-cancer-labex-mabimprove-industrial-workshop-july-27-28-2017-tours-france
#9
Camille Martin, Claire Kizlik-Masson, André Pèlegrin, Hervé Watier, Marie-Claude Viaud-Massuard, Nicolas Joubert
The annual "Antibody Industrial Symposium", co organized by LabEx MAbImprove, MabDesign and Polepharma, was held in Tours, France on June 27-28, 2017. The focus was on antibody-drug-conjugates (ADCs), new entities which realize the hope of Paul Ehrlich's magic bullet. ADCs result from the bioconjugation of a highly cytotoxic drug to a selective monoclonal antibody, which acts as a vector. Building on knowledge gained during the development of three approved ADCs, brentuximab vedotin (Adcetris®), ado trastuzumab emtansine (Kadcyla®) and inotuzumab ozogamicin (Besponsa®), and the many ADCs in development, this meeting addressed strategies and the latest innovations in the field from fundamental research to manufacturing...
December 14, 2017: MAbs
https://www.readbyqxmd.com/read/29228488/27-deutscher-hautkrebskongress-der-ado-in-mainz-ging-erfolgreich-zu-ende
#10
Kerstin Aldenhoff
No abstract text is available yet for this article.
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29219533/photonic-counterparts-of-cooper-pairs
#11
André Saraiva, Filomeno S de Aguiar Júnior, Reinaldo de Melo E Souza, Arthur Patrocínio Pena, Carlos H Monken, Marcelo F Santos, Belita Koiller, Ado Jorio
The microscopic theory of superconductivity raised the disruptive idea that electrons couple through the elusive exchange of virtual phonons, overcoming the strong Coulomb repulsion to form Cooper pairs. Light is also known to interact with atomic vibrations, as, for example, in the Raman effect. We show that photon pairs exchange virtual vibrations in transparent media, leading to an effective photon-photon interaction identical to that for electrons in the BCS theory of superconductivity, in spite of the fact that photons are bosons...
November 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29217763/improved-tumor-penetration-and-single-cell-targeting-of-antibody-drug-conjugates-increases-anticancer-efficacy-and-host-survival
#12
Cornelius Cilliers, Bruna Menezes, Ian Nessler, Jennifer Linderman, Greg Thurber
Current antibody-drug conjugates (ADC) have made advances in engineering the antibody, linker, conjugation site, small molecule payload and drug-to-antibody ratio (DAR). However, the relationship between heterogeneous intratumoral distribution and efficacy of ADC is poorly understood. Here we compared trastuzumab and ado-trastuzumab emtansine (T-DM1) to study the impact of ADC tumor distribution on efficacy. In a mouse xenograft model insensitive to trastuzumab, co-administration of trastuzumab with a fixed dose of T-DM1 at 3:1 and 8:1 ratios dramatically improved ADC tumor penetration and resulted in twice the improvement in median survival compared to T-DM1 alone...
December 7, 2017: Cancer Research
https://www.readbyqxmd.com/read/29209319/mesenchymal-stem-cells-induce-expression-of-cd73-in-human-monocytes-in-vitro-and-in-a-swine-model-of-myocardial-infarction-in-vivo
#13
Marta Monguió-Tortajada, Santiago Roura, Carolina Gálvez-Montón, Marcella Franquesa, Antoni Bayes-Genis, Francesc E Borràs
The ectoenzymes CD39 and CD73 regulate the purinergic signaling through the hydrolysis of adenosine triphosphate (ATP)/ADP to AMP and to adenosine (Ado), respectively. This shifts the pro-inflammatory milieu induced by extracellular ATP to the anti-inflammatory regulation by Ado. Mesenchymal stem cells (MSCs) have potent immunomodulatory capabilities, including monocyte modulation toward an anti-inflammatory phenotype aiding tissue repair. In vitro, we observed that human cardiac adipose tissue-derived MSCs (cATMSCs) and umbilical cord MSCs similarly polarize monocytes toward a regulatory M2 phenotype, which maintained the expression of CD39 and induced expression of CD73 in a cell contact dependent fashion, correlating with increased functional activity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29204929/what-about-the-girls-sex-based-differences-in-autistic-traits-and-adaptive-skills
#14
Allison B Ratto, Lauren Kenworthy, Benjamin E Yerys, Julia Bascom, Andrea Trubanova Wieckowski, Susan W White, Gregory L Wallace, Cara Pugliese, Robert T Schultz, Thomas H Ollendick, Angela Scarpa, Sydney Seese, Kelly Register-Brown, Alex Martin, Laura Gutermuth Anthony
There is growing evidence of a camouflaging effect among females with autism spectrum disorder (ASD), particularly among those without intellectual disability, which may affect performance on gold-standard diagnostic measures. This study utilized an age- and IQ-matched sample of school-aged youth (n = 228) diagnosed with ASD to assess sex differences on the ADOS and ADI-R, parent-reported autistic traits, and adaptive skills. Although females and males were rated similarly on gold-standard diagnostic measures overall, females with higher IQs were less likely to meet criteria on the ADI-R...
December 4, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29199395/projecting-the-cost-utilization-and-patient-care-impact-of-prescribing-extended-release-non-abuse-deterrent-opioids-to-chronic-pain-patients
#15
Mihran Ara Yenikomshian, Alan G White, Michael E Carson, Louis P Garrison, Gary M Oderda, Joseph E Biskupiak, Patrick R Hlavacek, Carl L Roland
OBJECTIVES: To estimate healthcare resource utilization, associated costs, and number needed to harm (NNH) from a physician's decision to prescribe extended-release (ER) non-abuse-deterrent opioids (non-ADO) as compared to ER ADOs in a chronic pain population. DESIGN: A 12-month probabilistic simulation model was developed to estimate the reduction of misuse and/or abuse from a physician's prescribing decisions for 10,000 patients. Model inputs included probabilities for opioid misuse and/or abuse-related events, opioid discontinuation, and switching from ADO to non-ADO...
September 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/29191006/selective-and-mechanically-robust-sensors-for-electrochemical-measurements-of-real-time-hydrogen-peroxide-dynamics-in-vivo
#16
Leslie R Wilson, Sambit Panda, Andreas C Schmidt, Leslie A Sombers
The role of hydrogen peroxide (H2O2) in the complex environment of the brain is not well understood. H2O2 plays several important roles - for instance, it serves as a key chemical player in normal physiological processes such as cellular respiration, a modulator of dopaminergic signaling, and its presence can indicate the upstream production of more aggressive and short-lived reactive oxygen species (ROS). As such, H2O2 has been implicated in several neurodegenerative diseases, including the slow destruction of dopaminergic neurons in Parkinson's disease (PD)...
December 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29189161/toxicology-of-trastuzumab-an-insight-into-mechanisms-of-cardiotoxicity
#17
Jie An, M Saeed Sheikh
Trastuzumab is a humanized monoclonal antibody that is approved for the treatment of breast and gastric malignancies. Although it has shown promise as a biotherapeutic, its cardiotoxicity remains a major concern. Genotoxic anticancer anthracyclines such as doxorubicin and epirubicin are also known for their cardiotoxic effects. However, trastuzumab and anthracyclines are suggested to mediate cardiotoxicity via different pathways. The available lines of evidence suggest that trastuzumab can exacerbate the cardiotoxic effects of anthracyclines and thus, prior exposure to anthracyclines is a regarded as one of the risk factors for trastuzumab-induced cardiotoxcity...
November 29, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29188180/comparison-of-orthologous-cyanobacterial-aldehyde-deformylating-oxygenases-in-the-production-of-volatile-c3-c7-alkanes-in-engineered-e-coli
#18
Pekka Patrikainen, Veronica Carbonell, Kati Thiel, Eva-Mari Aro, Pauli Kallio
Aldehyde deformylating oxygenase (ADO) is a unique enzyme found exclusively in photosynthetic cyanobacteria, which natively converts acyl aldehyde precursors into hydrocarbon products embedded in cellular lipid bilayers. This capacity has opened doors for potential biotechnological applications aiming at biological production of diesel-range alkanes and alkenes, which are compatible with the nonrenewable petroleum-derived end-products in current use. The development of production platforms, however, has been limited by the relative inefficiency of ADO enzyme, promoting research towards finding new strategies and information to be used for rational design of enhanced pathways for hydrocarbon over-expression...
December 2017: Metabolic Engineering Communications
https://www.readbyqxmd.com/read/29184552/multifaceted-effects-of-extracellular-adenosine-triphosphate-and-adenosine-in-the-tumor-host-interaction-and-therapeutic-perspectives
#19
REVIEW
Paola de Andrade Mello, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio
Cancer is still one of the world's most pressing health-care challenges, leading to a high number of deaths worldwide. Immunotherapy is a new developing therapy that boosts patient's immune system to fight cancer by modifying tumor-immune cells interaction in the tumor microenvironment (TME). Extracellular adenosine triphosphate (eATP) and adenosine (Ado) are signaling molecules released in the TME that act as modulators of both immune and tumor cell responses. Extracellular adenosine triphosphate and Ado activate purinergic type 2 (P2) and type 1 (P1) receptors, respectively, triggering the so-called purinergic signaling...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29182361/ado-trastuzumab-emtansine-t-dm1-in-her2-advanced-breast-cancer-patients-does-pretreatment-with-pertuzumab-matter
#20
Alessandra Fabi, Diana Giannarelli, Luca Moscetti, Daniele Santini, Alberto Zambelli, Michelino De Laurentiis, Michele Caruso, Daniele Generali, Enrichetta Valle, Vita Leonardi, Katia Cannita, Grazia Arpino, Gianfranco Filippelli, Gianluigi Ferretti, Marianna Giampaglia, Filippo Montemurro, Cecilia Nisticò, Simona Gasparro, Francesco Cognetti
AIM: We evaluated the outcomes of patients treated with ado-trastuzumab emantasine (T-DM1) after first-line pertuzumab/trastuzumab, compared with those receiving a trastuzumab-only-based regimen. PATIENTS & METHODS: Patients who received second-line T-DM1 after pertuzumab/trastuzumab (n = 34) were compared with those who received only trastuzumab (n = 73). RESULTS: Overall response rate was 33.3% in patients with prior pertuzumab and 57...
November 28, 2017: Future Oncology
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