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https://www.readbyqxmd.com/read/28097825/signalling-pathways-involved-in-hypoxia-induced-renal-fibrosis
#1
REVIEW
Minna Liu, Xiaoxuan Ning, Rong Li, Zhen Yang, Xiaoxia Yang, Shiren Sun, Qi Qian
Renal fibrosis is the common pathological hallmark of progressive chronic kidney disease (CKD) with diverse aetiologies. Recent researches have highlighted the critical role of hypoxia during the development of renal fibrosis as a final common pathway in end-stage kidney disease (ESKD), which joints the scientist's attention recently to exploit the molecular mechanism underlying hypoxia-induced renal fibrogenesis. The scaring formation is a multilayered cellular response and involves the regulation of multiple hypoxia-inducible signalling pathways and complex interactive networks...
January 18, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28095056/correlates-of-adaptive-functioning-in-minimally-verbal-children-with-autism-spectrum-disorder
#2
Kyle M Frost, Natalie Hong, Catherine Lord
Individuals with autism spectrum disorder (ASD) tend to have significant delays in adaptive functioning. In this study, the relationship between adaptive behavior and ASD symptomatology was investigated in minimally verbal, school-aged children with ASD (n = 333). Both the social affect (SA) and restricted and repetitive behavior (RRB) domains from the Autism Diagnostic Observation Schedule (ADOS) were analyzed in relation to adaptive skills. ADOS SA scores contributed unique variance to scores in each Vineland domain, though cognitive ability and age accounted for considerably more variance across domains...
January 2017: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28074216/adenosine-effectively-restores-endotoxin-induced-inhibition-of-human-neutrophil-chemotaxis-via-a1-receptor-p38-pathway
#3
Xiaohan Xu, Shuyun Zheng, Yuyun Xiong, Xu Wang, Weiting Qin, Huafeng Zhang, Bingwei Sun
Neutrophil chemotaxis plays an essential role in recruiting neutrophils to sites of inflammation. Neutrophil chemotaxis is suppressed both after exposure to lipopolysaccharide (LPS) in vitro and during clinical and experimental endotoxemia, leading to serious consequences. Adenosine (ADO) is a potent anti-inflammatory agent that acts on a variety of neutrophil functions. However, its effects on human neutrophil chemotaxis during infection have been less well characterized. In the present study, we investigated the effect of ADO and its receptor-specific antagonist and agonist on neutrophil chemotaxis in an in vitro LPS-stimulated model...
January 10, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28064558/a-hyperlexic-like-reading-style-is-associated-with-increased-autistic-features-in-girls-with-adhd
#4
Jakob Åsberg Johnels, Christopher Gillberg, Svenny Kopp
OBJECTIVE: Hyperlexic-like reading (defined as word decoding much better than comprehension) has been associated with autism spectrum disorder (ASD). Here we study correlates of a hyperlexic-like reading style (HPL) in ADHD, a condition known to co-occur both with reading difficulties and ASD. METHOD: We compared 10 girls with an ADHD diagnosis plus HPL with 26 with ADHD minus HPL. RESULTS: Girls with HPL scored marginally lower in reading comprehension but did not differ from non-HPL girls in IQ, vocabulary, or in the severity of ADHD ratings...
January 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28062707/optimization-of-a-pegylated-glucuronide-monomethylauristatin-e-linker-for-antibody-drug-conjugates
#5
Patrick J Burke, Joseph Z Hamilton, Scott C Jeffrey, Joshua H Hunter, Svetlana O Doronina, Nicole M Okeley, Jamie B Miyamoto, Martha E Anderson, Ivan J Stone, Michelle L Ulrich, Jessica K Simmons, Erica E McKinney, Peter D Senter, Robert P Lyon
The emergence of antibody-drug conjugates (ADC), such as brentuximab vedotin and ado-trastuzumab emtansine, has led to increased efforts to identify new payloads and develop improved drug-linker technologies. Most antibody payloads impart significant hydrophobicity to the ADC, resulting in accelerated plasma clearance and suboptimal in vivo activity, particularly for conjugates with high drug-to-antibody ratios (DAR). We recently reported on the incorporation of a discrete PEG24 polymer as a side chain in a β-glucuronidase-cleavable monomethylauristatin E (MMAE) linker to provide homogeneous DAR 8 conjugates with decreased plasma clearance and increased antitumor activity in xenograft models relative to a non-PEGylated control...
January 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28056739/from-natural-products-to-designer-drugs-development-and-molecular-mechanisms-of-action-of-novel-anti-microtubule-breast-cancer-therapeutics
#6
Tejashree Mahaddalkar, Manu Lopus
Microtubule-targeted drugs (MTDs) have been on the forefront of breast cancer chemotherapy. Classic MTDs, such as paclitaxel and their semisynthetic derivatives, have achieved considerable success in the clinical management of breast neoplasms. In order to improve the specificity and to reduce undesirable, dose-limiting toxicities of these drugs, a plethora of novel compounds are being synthesized and investigated in laboratories worldwide. Due to their crucial roles during cell division, and to the fact that the suppression of their innate 'dynamic instability' can arrest cell cycle progression, microtubules formed an attractive target for cancer chemotherapy...
4, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28009217/temporal-quantum-correlations-in-inelastic-light-scattering-from-water
#7
Mark Kasperczyk, Filomeno S de Aguiar Júnior, Cassiano Rabelo, Andre Saraiva, Marcelo F Santos, Lukas Novotny, Ado Jorio
Water is one of the most prevalent chemicals on our planet, an integral part of both our environment and our existence as a species. Yet it is also rich in anomalous behaviors. Here we reveal that water is a novel-yet ubiquitous-source for quantum correlated photon pairs at ambient conditions. The photon pairs are produced through Raman scattering, and the correlations arise from the shared quantum of a vibrational mode between the Stokes and anti-Stokes scattering events. We confirm the nonclassical nature of the produced photon pairs by showing that the cross-correlation and autocorrelations of the signals violate a Cauchy-Schwarz inequality by over 5 orders of magnitude...
December 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/28002360/evidence-of-mumps-infection-among-children-in-the-democratic-republic-of-congo
#8
Reena H Doshi, Vivian H Alfonso, Nicole A Hoff, Patrick Mukadi, Sue Gerber, Ado Bwaka, Stephen G Higgins, Guillaume Ngoie Mwamba, Emile Okitolonda, Jean-Jacques Muyembe, Anne W Rimoin
BACKGROUND: Mumps is an acute viral infection and while the infection is usually mild, complications can lead to permanent sequelae including brain damage and deafness. The burden of mumps is currently unknown the Democratic Republic of Congo (DRC), we therefore assessed susceptibility to mumps infection among children 6 - 59 months of age. METHODS: In collaboration with the 2013-2014 DRC Demographic and Health Survey (DHS), we conducted a serosurvey to assess population immunity to vaccine preventable diseases...
December 19, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27999336/debouganin-diabody-fusion-protein-overcomes-drug-resistance-to-adcs-comprised-of-anti-microtubule-agents
#9
Shilpa Chooniedass, Rachelle L Dillon, Arjune Premsukh, Peter J Hudson, Gregory P Adams, Glen C MacDonald, Jeannick Cizeau
Antibody drug conjugates (ADC), comprised of highly potent small molecule payloads chemically conjugated to a full-length antibody, represent a growing class of therapeutic agents. The targeting of cytotoxic payloads via the specificity and selectivity of the antibody has led to substantial clinical benefits. However, ADC potency can be altered by mechanisms of resistance such as overexpression of efflux pumps or anti-apoptotic proteins. DeBouganin is a de-immunized variant of bouganin, a ribosome-inactivating protein (RIP) that blocks protein synthesis, thereby leading to apoptosis...
December 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27997923/the-role-of-hmgb1-in-pial-arteriole-dilating-reactivity-following-subarachnoid-hemorrhage-in-rats
#10
Haoliang Xu, Benjarat Changyaleket, Tibor Valyi-Nagy, Randal O Dull, Dale A Pelligrino, David E Schwartz, Zhao Zhong Chong
High-mobility group box 1 protein (HMGB1) has been implicated in inflammatory responses, and is also associated with cerebral vasospasm after subarachnoid hemorrhage (SAH). However, there are no direct evident links between HMGB1 and cerebral vasospasm. We therefore investigated the effects of HMGB1 on pial arteriole reactivity following SAH in rats. We initially found that SAH induced a significant decrease in pial arteriole dilating responses to sciatic nerve stimulation (SNS), hypercapnia (CO2), and the topical suffusion of acetylcholine (ACh), adenosine (ADO), and s-nitroso-N-acetylpenicillamine (SNAP) over a 7-day period after SAH...
December 21, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27992809/much-ado-about-everything-a-literature-review-of-insight-in-first-episode-psychosis-and-schizophrenia
#11
J Elowe, P Conus
No abstract text is available yet for this article.
December 16, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27987063/increased-eye-contact-during-conversation-compared-to-play-in-children-with-autism
#12
Rebecca M Jones, Audrey Southerland, Amarelle Hamo, Caroline Carberry, Chanel Bridges, Sarah Nay, Elizabeth Stubbs, Emily Komarow, Clay Washington, James M Rehg, Catherine Lord, Agata Rozga
Children with autism have atypical gaze behavior but it is unknown whether gaze differs during distinct types of reciprocal interactions. Typically developing children (N = 20) and children with autism (N = 20) (4-13 years) made similar amounts of eye contact with an examiner during a conversation. Surprisingly, there was minimal eye contact during interactive play in both groups. Gaze behavior was stable across 8 weeks in children with autism (N = 15). Lastly, gaze behavior during conversation but not play was associated with autism social affect severity scores (ADOS CSS SA) and the Social Responsiveness Scale (SRS-2)...
December 16, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27977875/developmental-changes-in-neuromagnetic-rhythms-and-network-synchrony-in-autism
#13
Vasily A Vakorin, Sam M Doesburg, Rachel C Leung, Vanessa M Vogan, Evdokia Anagnostou, Margot J Taylor
OBJECTIVE: There is gathering consensus that altered connectivity is a hallmark of the autistic brain. This includes atypical neural oscillations and their coordination across brain regions, which are understood to mediate information processing and integration. It remains unclear if and how connectivity in various neurophysiological frequency ranges develops atypically in autism spectrum disorder. METHODS: To address this in a cross-sectional sample, we recorded resting-state magnetoencephalography (MEG) from 134 children and adolescents with and without ASD, and calculated resting spectral power and inter-regional synchrony (functional connectivity)...
December 15, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27976868/thermodynamics-of-the-purine-nucleoside-phosphorylase-reaction-revealed-by-computer-simulations
#14
Geir Villy Isaksen, Johan Åqvist, Bjørn Olav Brandsdal
Enzymes are able to catalyze chemical reactions by reducing the activation free energy, yielding significant increases in the reaction rates. This can thermodynamically be accomplished by either reducing the activation enthalpy or increasing the activation entropy. The effect of remote mutations on the thermodynamic activation parameters of human purine nucleoside phosphorylase is examined using extensive molecular dynamics and free energy simulations. More than 2700 independent reaction free energy profiles for six different temperatures have been calculated to obtain high-precision computational Arrhenius plots...
December 27, 2016: Biochemistry
https://www.readbyqxmd.com/read/27960575/assessing-the-impact-of-abuse-deterrent-opioids-ados-identifying-epidemiologic-factors-related-to-new-entrants-with-low-population-exposure
#15
Carl L Roland, Beatrice Setnik, David A Brown
OBJECTIVE: Prescription opioid misuse and abuse is a serious public health concern that can lead to overdose, addiction, and death. The development of opioid formulations designed to deter misuse and abuse is considered an important step towards addressing the problem, but the extent to which abuse-deterrent opioids (ADOs) actually deter abuse in the community requires confirmation through epidemiologic studies. Epidemiologic evaluations of misuse and abuse present several unique challenges related to study design, sources of data, and methodology, particularly for new entrant ADOs with low population exposure...
January 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/27933285/developmental-profile-and-diagnoses-in-children-presenting-with-motor-stereotypies
#16
Francesco Cardona, Francesca Valente, Daniela Miraglia, Caterina D'Ardia, Valentina Baglioni, Flavia Chiarotti
INTRODUCTION: Motor stereotypies represent a typical example of the difficulty in distinguishing non-clinical behaviors (physiological and transient) from symptoms or among different disorders ["primary stereotypies," associated with autistic spectrum disorder (ASD), intellectual disabilities, genetic syndromes, and sensory impairment]. The aim of this study was to obtain an accurate assessment on the relationship between stereotypies and neurodevelopmental disorders. METHODS: We studied 23 children (3 girls), aged 36-95 months, who requested a consultation due to the persistence or increased severity of motor stereotypies...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27919649/maldi-tof-ms-identification-of-species-from-the-acinetobacter-baumannii-ab-group-revisited-inclusion-of-the-novel-a-%C3%A2-seifertii-and-a-%C3%A2-dijkshoorniae-species
#17
M Marí-Almirall, C Cosgaya, P G Higgins, A Van Assche, M Telli, G Huys, B Lievens, H Seifert, L Dijkshoorn, I Roca, Jordi Vila
OBJECTIVES: Rapid identification of Acinetobacter species is critical as members of the A. baumannii (Ab) group differ in antibiotic susceptibility and clinical outcomes. A. baumannii, A. pittii, and A. nosocomialis can be identified by MALDI-TOF/MS, while the novel species A. seifertii and A. dijkshoorniae cannot. Low identification rates for A. nosocomialis also have been reported. We evaluated the use of MALDI-TOF/MS to identify isolates of A. seifertii and A. dijkshoorniae and revisited the identification of A...
December 3, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27911956/adenosine-stimulate-proliferation-and-migration-in-triple-negative-breast-cancer-cells
#18
Miriam Fernandez-Gallardo, Ricardo González-Ramírez, Alejandro Sandoval, Ricardo Felix, Eduardo Monjaraz
Emerging evidence suggests that the adenosine (Ado) receptors may play crucial roles in tumor progression. Here, we show that Ado increases proliferation and migration in a triple negative breast cancer model, the MDA-MB 231 cell line. The use of specific agonists and antagonists evidenced that these effects depend on the activation of the A2B receptor, which then triggers an intracellular response mediated by the adenylate cyclase/PKA/cAMP signaling pathway. Ado also increases the expression of NaV1.5 channels, a potential biomarker in breast cancer...
2016: PloS One
https://www.readbyqxmd.com/read/27898501/off-label-use-of-amplatzer-duct-occluder-ii-additional-sizes
#19
Heba T Mahmoud, Giuseppe Santoro, Cristina Capogrosso, Maria G Russo
OBJECTIVE: To report our experience on novel, off-label use of Amplatzer Duct Occluder type II additional sizes (ADO II-AS) device (St. Jude Medical, Inc.; St. Paul, Minnesota, USA) to manage nonduct shunt lesions. METHODS AND RESULTS: Among the 114 patients submitted to ADO II-AS implantation at our institution, 12 received this device as off-label treatment of paravalvular leak (n = 5), sinus of Valsalva fissuration (n = 2), accessory atrial septal defect (n = 2), muscular ventricular septal defect (n = 1), bleeding bronchial artery aneurysm (n = 1) and reverse shunt due to abnormal origin of left subclavian artery from pulmonary artery (n = 1)...
November 24, 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/27897270/trueprime-is-a-novel-method-for-whole-genome-amplification-from-single-cells-based-on-tthprimpol
#20
Ángel J Picher, Bettina Budeus, Oliver Wafzig, Carola Krüger, Sara García-Gómez, María I Martínez-Jiménez, Alberto Díaz-Talavera, Daniela Weber, Luis Blanco, Armin Schneider
Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a potent primase activity preferring dNTPs as substrates unlike conventional primases. A combination of TthPrimPol's unique ability to synthesize DNA primers with the highly processive Phi29 DNA polymerase (Φ29DNApol) enables near-complete whole genome amplification from single cells...
November 29, 2016: Nature Communications
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