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https://www.readbyqxmd.com/read/28648235/much-ado-about%C3%A2-a-response-to-hardy-et-al
#1
Dave Collins, Áine MacNamara
Our response to the Great British Medallist (GBM) study focuses on three concerns. First, we discuss the extent to which the findings presented are actually novel and offer practitioners genuine guidance and information about how to structure talent development pathways. Second, we suggest that a lack of critical consideration of the findings against the considerable body of knowledge that already exists in this domain is a significant limitation. Finally, and most pertinently from a practitioner perspective, we highlight our concerns about the extent to which the findings presented may be prematurely adopted by practitioners without a genuinely appropriate evidence base...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/28639396/the-influence-of-parental-concern-on-the-utility-of-autism-diagnostic-instruments
#2
Karoline Alexandra Havdahl, Somer L Bishop, Pål Surén, Anne-Siri Øyen, Catherine Lord, Andrew Pickles, Stephen von Tetzchner, Synnve Schjølberg, Nina Gunnes, Mady Hornig, W Ian Lipkin, Ezra Susser, Michaeline Bresnahan, Per Magnus, Nina Stenberg, Ted Reichborn-Kjennerud, Camilla Stoltenberg
The parental report-based Autism Diagnostic Interview-Revised (ADI-R) and the clinician observation-based Autism Diagnostic Observation Schedule (ADOS) have been validated primarily in U.S. clinics specialized in autism spectrum disorder (ASD), in which most children are referred by their parents because of ASD concern. This study assessed diagnostic agreement of the ADOS-2 and ADI-R toddler algorithms in a more broadly based sample of 679 toddlers (age 35-47 months) from the Norwegian Mother and Child Cohort...
June 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28638324/stochastic-signatures-of-involuntary-head-micro-movements-can-be-used-to-classify-females-of-abide-into-different-subtypes-of-neurodevelopmental-disorders
#3
Elizabeth B Torres, Sejal Mistry, Carla Caballero, Caroline P Whyatt
Background: The approximate 5:1 male to female ratio in clinical detection of Autism Spectrum Disorder (ASD) prevents research from characterizing the female phenotype. Current open access repositories [such as those in the Autism Brain Imaging Data Exchange (ABIDE I-II)] contain large numbers of females to help begin providing a new characterization of females on the autistic spectrum. Here we introduce new methods to integrate data in a scale-free manner from continuous biophysical rhythms of the nervous systems and discrete (ordinal) observational scores...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28625201/a-perspective-on-the-editorial-by-ken-gillman-much-ado-about-nothing-monoamine-oxidase-inhibitors-drug-interactions-and-dietary-tyramine
#4
https://www.readbyqxmd.com/read/28622245/iodinated-contrast-medium-renal-toxicity-the-phantom-menace-or-much-ado-about-nothing
#5
Karim Lakhal, Stephan Ehrmann, Vincent Robert-Edan
No abstract text is available yet for this article.
July 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28602448/adaptation-of-social-and-non-social-cues-to-direction-in-adults-with-autism-spectrum-disorder-and-neurotypical-adults-with-autistic-traits
#6
Rebecca P Lawson, Jessica Aylward, Jonathan P Roiser, Geraint Rees
Perceptual constancy strongly relies on adaptive gain control mechanisms, which shift perception as a function of recent sensory history. Here we examined the extent to which individual differences in magnitude of adaptation aftereffects for social and non-social directional cues are related to autistic traits and sensory sensitivity in healthy participants (Experiment 1); and also whether adaptation for social and non-social directional cues is differentially impacted in adults with Autism Spectrum Disorder (ASD) relative to neurotypical (NT) controls (Experiment 2)...
May 17, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28599124/three-dimensional-reconstruction-of-post-traumatic-deficient-anterior-maxilla
#7
Adi Rachmiel, Dekel Shilo, Dror Aizenbud, Mark Pen, Dana Rachmiel, Omri Emodi
PURPOSE: Maxillary retrognathism appears in 14.3% of patients exhibiting malocclusion after trauma treatment. This report describes the application of alveolar distraction osteogenesis (ADO) for treating the severely deficient anterior maxilla after trauma injuries in the vertical and anteroposterior planes. MATERIALS AND METHODS: This is a retrospective study of patients exhibiting severe vertical and anteroposterior maxillary bone deficiency after trauma injuries and treated by ADO as a first stage with additional Le Fort I advancement when required...
May 15, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28597187/examining-the-role-of-race-ethnicity-and-gender-on-social-and-behavioral-ratings-within-the-autism-diagnostic-observation-schedule
#8
Ashley J Harrison, Kristin A Long, Douglas C Tommet, Richard N Jones
The Autism Diagnostic Observation Schedule (ADOS) is widely used to assess symptoms of autism spectrum disorder (ASD). Given well-documented differences in social behaviors across cultures, this study examined whether item-level biases exist in ADOS scores across sociodemographic groups (race, ethnicity, and gender). We examined a subset of ten ADOS items among participants (N = 2458). Holding level of overall ADOS behavioral symptoms constant, we found significant item level bias (measurement noninvariance) for race and ethnicity on three ADOS items...
June 8, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28593359/guided-growth-for-valgus-deformity-correction-of-knees-in-a-girl-with-osteopetrosis-a-case-report
#9
Dmitry Popkov
Autosomal dominant osteopetrosis (Albers-Schönberg disease) classically displays the radiographic signs of osteosclerosis. The main ADO complications involve the skeleton: low-impact bone fractures, scoliosis and hip osteoarthritis. Management of osteopetrosis-related orthopedic problems is a surgical challenge due to increased bone density. The healing process is very slow in these patients because of bone remodeling defects related to osteoblast function failure. In case of bone deformities, a realignment method should be appropriated to osteopetrosis conditions...
June 7, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28592997/diagnoses-and-characteristics-of-autism-spectrum-disorders-in-children-with-prader-willi-syndrome
#10
Elisabeth M Dykens, Elizabeth Roof, Hailee Hunt-Hawkins, Nathan Dankner, Evon Batey Lee, Carolyn M Shivers, Christopher Daniell, Soo-Jeong Kim
BACKGROUND: A small percentage of people with autism spectrum disorders (ASD) have alterations in chromosome 15q11.2-q3, the critical region for Prader-Willi syndrome (PWS). Data are limited, however, on the rates and characteristics of ASD in PWS. Previous estimates of ASD in PWS (25 to 41%) are questionable as they are based solely on autism screeners given to parents. Inaccurate diagnoses of ASD in PWS can mislead intervention and future research. METHODS: One hundred forty-six children and youth with PWS aged 4 to 21 years (M = 11) were assessed with the Autism Diagnostic Observation Schedule-2 (ADOS-2)...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28592109/the-roles-of-the-active-site-zn-ii-and-residues-in-substrate-discrimination-by-threonyl-trna-synthetase-an-md-and-qm-mm-investigation
#11
Mohamed M Aboelnga, James Wilson Gauld
Threonyl-tRNA synthetase (ThrRS) is a Zn(II) containing enzyme that catalyzes the activation of threonine and its subsequent transfer to the cognate tRNA. This process is accomplished with remarkable fidelity, with ThrRS being able to discriminate its cognate substrate from similar analogs such as serine and valine. Molecular dynamics (MD) simulations and hybrid Quantum Mechanics/Molecular Mechanics (QM/MM) methods have been used to elucidate the role of Zn(II) in the aminoacylation mechanism of ThrRS. More specifically, the role of Zn(II) and active site residues in ThrRS's ability to discriminate between its cognate substrate L-threonine, and the non-cognate L-serine, L-valine and D-threonine has been examined...
June 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28590059/sympatholytic-effect-of-intravascular-atp-is-independent-of-nitric-oxide-prostaglandins-na-k-atpase-and-kir-channels-in-humans
#12
Christopher M Hearon, Jennifer C Richards, Mathew L Racine, Gary J Luckasen, Dennis G Larson, Michael J Joyner, Frank A Dinenno
Exercise and intravascular ATP elicit vasodilatation that is dependent on activation of inwardly rectifying potassium (KIR ) channels, with a modest reliance on nitric oxide (NO) and prostaglandin (PG) synthesis.  Both exercise and intravascular ATP attenuate sympathetic α-adrenergic vasoconstriction (sympatholysis). However, KIR channels, NO, PGs and Na(+) /K(+) -ATPase activity are not obligatory to observe sympatholysis during exercise. To further determine similarities between exercise and intravascular ATP, we tested the hypothesis that inhibition of KIR channels, NO and PG synthesis, and Na(+) /K(+) -ATPase, would not alter the ability of ATP to blunt α1 -adrenergic vasoconstriction...
June 7, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28589494/the-accuracy-of-the-ados-2-in-identifying-autism-among-adults-with-complex-psychiatric-conditions
#13
Brenna B Maddox, Edward S Brodkin, Monica E Calkins, Kathleen Shea, Katherine Mullan, Jack Hostager, David S Mandell, Judith S Miller
The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), Module 4 is considered a "gold-standard" instrument for diagnosing autism spectrum disorder (ASD) in adults. Although the ADOS-2 shows good sensitivity and specificity in lab-based settings, it is unknown whether these results hold in community clinics that serve a more psychiatrically impaired population. This study is the first to evaluate the diagnostic accuracy of the ADOS-2 among adults in community mental health centers (n = 75)...
June 6, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28588598/genetic-gains-in-grain-yield-of-a-maize-population-improved-through-marker-assisted-recurrent-selection-under-stress-and-non-stress-conditions-in-west-africa
#14
Rekiya O Abdulmalik, Abebe Menkir, Silvestro K Meseka, Nnanna Unachukwu, Shehu G Ado, Joseph D Olarewaju, Daniel A Aba, Sarah Hearne, Jose Crossa, Melaku Gedil
Marker-assisted recurrent selection (MARS) is a breeding method used to accumulate favorable alleles that for example confer tolerance to drought in inbred lines from several genomic regions within a single population. A bi-parental cross formed from two parents that combine resistance to Striga hermonthica with drought tolerance, which was improved through MARS, was used to assess changes in the frequency of favorable alleles and its impact on inbred line improvement. A total of 200 testcrosses of randomly selected S1 lines derived from the original (C0) and advanced selection cycles of this bi-parental population, were evaluated under drought stress (DS) and well-watered (WW) conditions at Ikenne and under artificial Striga infestation at Abuja and Mokwa in Nigeria in 2014 and 2015...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28587087/taurine-biosynthesis-in-a-fish-liver-cell-line-zfl-adapted-to-a-serum-free-medium
#15
Chieh-Lun Liu, Aaron M Watson, Allen R Place, Rosemary Jagus
Although taurine has been shown to play multiple important physiological roles in teleosts, little is known about the molecular mechanisms underlying dietary requirements. Cell lines can provide useful tools for deciphering biosynthetic pathways and their regulation. However, culture media and sera contain variable taurine levels. To provide a useful cell line for the investigation of taurine homeostasis, an adult zebrafish liver cell line (ZFL) has been adapted to a taurine-free medium by gradual accommodation to a commercially available synthetic medium, UltraMEM™-ITES...
May 25, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28571033/how-to-develop-intelligence-gathering-in-efficient-and-practical-anti-doping-activities
#16
Mathieu Holz, Jack Robertson
Prior to the formation of the World Anti-Doping Agency (WADA), the fight against doping in sport was not unified; instead, it relied on individual approaches established by various stakeholders to make it effective. The scandal of the Festina Affair, during the Tour de France 1998, and other drug doping scandals revealed the ineffectiveness and inadequacy of such an approach. The resulting media scandal raised public authorities' awareness about the necessity to deal with doping in sport with a harmonized and a more effective approach...
2017: Medicine and Sport Science
https://www.readbyqxmd.com/read/28571022/therapeutic-use-exemptions
#17
David Gerrard, Andrew Pipe
The introduction, in 2004, of the World Anti-Doping Code and a standardized "prohibited list" of substances and methods proscribed in sport represented a consistent, international response to the escalating challenge of drug misuse in contemporary sport. Simultaneously, it was recognized that athletes experiencing illness or injury might legitimately require the use of "prohibited" medications or procedures, and the concept of the "therapeutic use exemption" (TUE) was introduced. The mechanisms of the TUE process are carefully defined and described in a specific WADA "international standard" (IS)...
2017: Medicine and Sport Science
https://www.readbyqxmd.com/read/28567489/discovery-of-two-small-circular-ssdna-viruses-associated-with-the-whitefly-bemisia-tabaci
#18
Erich Y T Nakasu, Fernando L Melo, Miguel Michereff-Filho, Tatsuya Nagata, Bergmann M Ribeiro, Simone G Ribeiro, Cristiano Lacorte, Alice K Inoue-Nagata
The complete genome sequences of two novel small circular DNA viruses isolated from sweet-potato whiteflies collected in central-West (AdDF) and Southeast (AdO) regions of Brazil were determined by Next Generation Sequencing (NGS), and confirmed by cloning and Sanger sequencing. The genomes are 2,199 and 2,211 nt-long, respectively, encoding a putative coat protein (CP) and a replication-associated protein (Rep) and showing a genomic organization typical of viruses from the family Genomoviridae. Phylogenetic analysis with deduced amino acid sequences of Rep indicates that the virus from AdO is closely related to other members of the genus Gemycircularvirus, while the virus from AdDF is distantly related to other genomovirus...
May 31, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28566822/cost-effectiveness-analysis-of-different-devices-used-for-the-closure-of-small-to-medium-sized-patent-ductus-arteriosus-in-pediatric-patients
#19
Sonia A El-Saiedi, Amal M El Sisi, Rodina Sobhy Mandour, Doaa M Abdel-Aziz, Wael A Attia
AIMS: In this study, we examined the differences in cost and effectiveness of various devices used for the closure of small to medium sized patent ductus arteriosus (PDA). SETTING AND DESIGN: We retrospectively studied 116 patients who underwent closure of small PDAs between January 2010 and January 2015. SUBJECTS AND METHODS: Three types of devices were used: the Amplatzer duct occluder (ADO) II, the cook detachable coil and the Nit Occlud coil (NOC)...
May 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28560107/factors-affecting-genotyping-success-in-giant-panda-fecal-samples
#20
Ying Zhu, Hong-Yi Liu, Hai-Qiong Yang, Yu-Dong Li, He-Min Zhang
Fecal samples play an important role in giant panda conservation studies. Optimal preservation conditions and choice of microsatellites for giant panda fecal samples have not been established. In this study, we evaluated the effect of four factors (namely, storage type (ethanol (EtOH), EtOH -20 °C, 2-step storage medium, DMSO/EDTA/Tris/salt buffer (DETs) and frozen at -20 °C), storage time (one, three and six months), fragment length, and repeat motif of microsatellite loci) on the success rate of microsatellite amplification, allelic dropout (ADO) and false allele (FA) rates from giant panda fecal samples...
2017: PeerJ
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