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kikuchi guidelines

Naoki Fujita, Nobuko Nabetani, Norimasa Umemura, Chigusa Kikuchi, Tadashi Suzuki
  In this study, we took continuous measurements of hemoglobin A1c (HbA1c) levels and conducted lifestyle checks in three cases to determine if these parameters were effective in improving overall wellness. We selected three young men with relatively high HbA1c levels. During the 12-weeks study periods, we regularly measured each participant's HbA1c levels and monitored their lifestyle habits every two weeks at the community pharmacy once every 2 weeks using specific guidelines. The first participant, a 23-year-old man, had a HbA1c level of 5...
June 28, 2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Hiroshi Watanabe, Kazunari Ishii, Makoto Hosono, Etsuko Imabayashi, Koichiro Abe, Masayuki Inubushi, Kazuko Ohno, Yasuhiro Magata, Kinya Ono, Kei Kikuchi, Kei Wagatsuma, Tadashi Takase, Kyoko Saito, Yasuyuki Takahashi
OBJECTIVE: The optimization of medical exposure is one of the major issues regarding radiation protection in the world, and The International Committee of Radiological Protection and the International Atomic Energy Agency recommend establishing diagnostic reference levels (DRLs) as tools for dose optimization. Therefore, the development of DRLs based on the latest survey has been required for nuclear medicine-related societies and organizations. This prompted us to conduct a nationwide survey on the actual administered radioactivity to adults for the purpose of developing DRLs in nuclear medicine...
July 2016: Annals of Nuclear Medicine
Mitsuhiro Tozaki, Yoshifumi Kuroki, Mari Kikuchi, Yasuyuki Kojima, Kazunori Kubota, Hiroshi Nakahara, Yoshinori Ito, Hirofumi Mukai
No abstract text is available yet for this article.
May 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Mikio Kikuchi, Masamitsu Nakagawa, Suguru Tone, Hotaka Saito, Tatsuhiro Niino, Natsumi Nagasawa, Jun Sawai
The influence of two vehicles (N,N-dimethylformamide [DMF] as solvent and polyoxyethylene hydrogenated castor oil [HCO-40] as a dispersant) on the acute toxicity of eight hydrophobic chemicals with a non-specific mode of action to Daphnia magna was investigated according to the OECD Guidelines for the Testing of Chemicals, No. 202. An increased 48-h EC50 value for D. magna or reduced toxicity resulting from the addition of HCO-40 to the test medium was observed for five of the eight chemicals examined. Each of eight chemicals was dissolved in water at a concentration of either 10 mg/L or 1...
July 2016: Chemosphere
Hiroshi Yokouchi, Takashi Ishida, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Tatsuro Fukuhara, Kei Takamura, Tetsuya Kojima, Toshiyuki Harada, Mitsunori Higuchi, Yoshifumi Matsuura, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Hiroshi Nishihara, Hiroyuki Suzuki, Hirotoshi Dosaka-Akita, Hiroshi Isobe, Masaharu Nishimura, Mitsuru Munakata
OBJECTIVES: Several American and Japanese guidelines recommend surgery for patients with c-stage I small-cell lung cancer (SCLC), whereas the European Society of Medical Oncology (ESMO) guidelines recommend surgery for patients with not only c-stage I but also c-stage II (T2N1) SCLC. In addition, previous studies identified various factors other than clinical stage that are related to survival in these patients. Thus, further validation and examination of the association of clinical stage and other clinical variables with survival are required for establishing practical management of early-stage SCLC...
December 2015: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Naoki Kikuchi, Koichi Nakazato
Training variants (type, intensity, and duration of exercise) can be selected according to individual aims and fitness assessment. Recently, various methods of resistance and endurance training have been used for muscle hypertrophy and VO2max improvement. Although several genetic variants are associated with elite athletic performance and muscle phenotypes, genetic background has not been used as variant for physical training. ACTN3 R577X is a well-studied genetic polymorphism. It is the only genotype associated with elite athletic performance in multiple cohorts...
September 2015: Journal of Exercise Nutrition & Biochemistry
Shinya Ohashi, Shin'ichi Miyamoto, Osamu Kikuchi, Tomoyuki Goto, Yusuke Amanuma, Manabu Muto
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive squamous cell carcinomas and is highly prevalent in Asia. Alcohol and its metabolite, acetaldehyde, are considered definite carcinogens for the esophagus. Polymorphisms in the aldehyde dehydrogenase 2 gene, which encodes an enzyme that eliminates acetaldehyde, have been associated with esophageal carcinogenesis. Studies of the mutagenic and carcinogenic effects of acetaldehyde support this observation. Several recent large-scale comprehensive analyses of the genomic alterations in ESCC have shown a high frequency of mutations in genes such as TP53 and others that regulate the cell cycle or cell differentiation...
December 2015: Gastroenterology
Naoko Sato, Tomonobu Hasegawa, Yukihiro Hasegawa, Osamu Arisaka, Keiichi Ozono, Shin Amemiya, Toru Kikuchi, Hiroyuki Tanaka, Shohei Harada, Ichiro Miyata, Toshiaki Tanaka
Male hypogonadotropic hypogonadism (MHH), a disorder associated with infertility, is treated with testosterone replacement therapy (TRT) and/or gonadotropins replacement therapy (GRT) (TRT and GRT, together with HRT hormone replacement therapy). In Japan, guidelines have been set for treatment during adolescence. Due to the risk of rapid maturation of bone age, low doses of testosterone or gonadotropins have been used. However, the optimal timing and methods of therapeutic intervention have not yet been established...
April 2015: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
L M Wang, R Guy, E Fryer, C Kartsonaki, P Gill, C Hughes, A Szuts, R Perera, R Chetty, N Mortensen
AIM: Early pT1 polyp colorectal cancers (CRCs) present challenges for accurate pathology substaging. Haggitt and Kikuchi stages depend on polyp morphology and are often difficult to apply due to suboptimal orientation or fragmentation, or absence of the muscularis propria in polypectomy or submucosal resection specimens. European guidelines for quality assurance suggest using Ueno's more objective approach, using depth and width measurements beyond muscularis mucosae. We have investigated interobserver variation using Ueno's approach...
August 2015: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Kayoko Kikuchi, Yoshitaka Miyakawa, Shunya Ikeda, Yuji Sato, Toru Takebayashi
BACKGROUND: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease in which the platelet count falls to <100 × 10(9)/L. Corticosteroids are recommended as the first-line treatment, splenectomy is recommended as the second-line treatment, and thrombopoietin receptor agonists (TPO-RAs) and rituximab are recommended as the third-line treatments for ITP in Japanese ITP treatment guidelines. However, in Japan, rituximab is not eligible for reimbursement for the treatment of ITP...
2015: BMC Health Services Research
Hiroyuki Komatsu, Hideto Nakagawa, Takashi Iwakiri, Tatsunori Toida, Akihiro Fukuda, Masao Kikuchi, Yuji Sato, Kazuo Kitamura, Shouichi Fujimoto
BACKGROUND AND OBJECTIVES: Little is known about the treatment and clinical status of patients with biopsy-proven IgA nephropathy (IgAN) during long-term maintenance dialysis. METHODS: Fifty-two of 433 patients with IgAN who had favorable survival rates of 93.3% and 65.1% at 10 and 20 years, respectively, in a previous study and had reached end-stage kidney disease were followed up for 11.1 ± 6.2 years. Forty of the 52 patients undergoing hemodialysis (HD) or peritoneal dialysis (PD) at the final observation in February 2012 were eligible for entry in this study...
2014: Nihon Jinzo Gakkai Shi
Hidetoshi Shiga, Hiroyuki Hirasawa, Osamu Nishida, Shigeto Oda, Masataka Nakamura, Kunihiro Mashiko, Kenich Matsuda, Nobuya Kitamura, Yoshihiko Kikuchi, Nobuo Fuke
BACKGROUND/AIM: We investigated the clinical efficacy of continuous hemodiafiltration (CHDF) with AN69ST hemofilter (AN69ST-CHDF) in patients with septic shock. MATERIALS AND METHODS: A prospective, multicenter, single-arm study was conducted. Patients with sepsis and shock defined by hyperlactemia were enrolled. The patients were treated with CHDF and in accordance with the Surviving Sepsis Campaign guidelines (SSCG). RESULTS: Thirty-four patients were enrolled...
2014: Blood Purification
Suguru Shirotake, Eiji Kikuchi, Nobuyuki Tanaka, Kazuhiro Matsumoto, Yasumasa Miyazaki, Hiroaki Kobayashi, Hiroki Ide, Jun Obata, Katsura Hoshino, Gou Kaneko, Masayuki Hagiwara, Takeo Kosaka, Kent Kanao, Kiichiro Kodaira, Satoshi Hara, Masafumi Oyama, Tetsuo Momma, Akira Miyajima, Ken Nakagawa, Shintaro Hasegawa, Yosuke Nakajima, Mototsugu Oya
PURPOSE: Current guidelines do not yet provide any recommendations for adjuvant chemotherapy in patients with upper tract urothelial carcinoma managed with radical nephroureterectomy. We evaluated whether an adjuvant chemotherapeutic regimen would affect the clinical outcome in patients with high risk upper tract urothelial carcinoma. MATERIALS AND METHODS: We identified 873 patients who had undergone radical nephrouretectomy for localized upper tract urothelial carcinoma at 14 Japanese institutions between 1993 and 2011...
April 2015: Journal of Urology
Yasuhiro Tsubokura, Sunao Aso, Takayuki Koga, Junichi Kikuchi, Toshio Kobayashi, Satsuki Hoshuyama, Yutaka Oshima, Katsumi Miyata, Yuji Kusune, Takako Muroi, Tomohiko Yoshida, Ryuichi Hasegawa, Shozo Ajimi, Kotaro Furukawa
4-Methoxy-2-nitroaniline (4M2NA) is widely used as an intermediate for the synthesis of dyes, pigments and other chemical compounds. Since 4M2NA has amino-group and nitro-group on the benzene ring, it was expected that it induced obvious hemolytic anemia. We conducted a combined repeated dose and reproductive/developmental toxicity screening test according to Organisation for Economic Co-operation and Development (OECD) Test Guideline No. 422 (OECD TG 422) to enrich the toxic information and ensure the safety of 4M2NA...
October 2015: Drug and Chemical Toxicology
Atsuo Nakagawa, Mitsuhiro Sado, Dai Mitsuda, Daisuke Fujisawa, Toshiaki Kikuchi, Takayuki Abe, Yuji Sato, Satoru Iwashita, Masaru Mimura, Yutaka Ono
INTRODUCTION: Major depression is a serious mental disorder that causes substantial distress and impairment in individuals and places an enormous burden on society. Although antidepressant treatment is the most common therapy provided in routine practice, there is little evidence to guide second-line therapy for patients who have failed to respond to antidepressants. The aim of this paper is to describe the study protocol for a randomised controlled trial that measures the clinical effectiveness of cognitive behavioural therapy (CBT) as an augmentation strategy to treat patients with non-psychotic major depression identified as suboptimal responders to usual depression care...
2014: BMJ Open
Luciana Kikuchi, Claudia P Oliveira, Mario R Alvares-da-Silva, Claudia M Tani, Marcio A Diniz, Jose T Stefano, Aline L Chagas, Regiane S S M Alencar, Denise C P Vezozzo, Gilmar R Santos, Priscila B Campos, Venancio Af Alves, Vlad Ratziu, Flair J Carrilho
BACKGROUND/AIMS: Nonalcoholic fatty liver disease (NAFLD) has emerged as an important cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). The Barcelona Clinic Liver Cancer (BCLC) system is the preferred staging system to evaluate patients with HCC and links prognosis assessment with treatment recommendation. The aim of this retrospective study was to evaluate whether the BCLC staging system and its treatment algorithm are suitable for patients with HCC arising from NAFLD...
October 2016: American Journal of Clinical Oncology
Mototsugu Oya, Eiji Kikuchi
Upper tract urothelial carcinoma is more rare than bladder cancer, although they are both categorized as urothelial carcinoma. Because of the low incidence, little clinical evidence is available regarding the treatment of the former. However, recently such evidence has slowly begun to accumulate. The guideline presented herein was compiled for the purpose of ensuring proper diagnosis and treatment by physicians involved in the treatment of upper tract urothelial carcinoma. We carefully selected 16 clinical questions essential for daily clinical practice and grouped them into four major categories: epidemiology, diagnosis, surgery and systemic chemotherapy/other matters...
January 2015: International Journal of Urology: Official Journal of the Japanese Urological Association
Shinji Katsuragi, Julian T Parer, Shunichi Noda, Junji Onishi, Hitomi Kikuchi, Tomoaki Ikeda
UNLABELLED: Abstracts Objective: We have reported a 7-fold reduction in newborn umbilical arterial (UA) metabolic acidemia after adoption of a rule-based 5-category color-coded fetal heart rate (FHR) management framework. We sought evidence for the relationship being causal by detailed analysis of FHR characteristics and acid-base status before and after training. METHODS: Rates of UA pH and base excess (BE) were determined over a 5-year period in a single Japanese hospital, serving mainly low-risk patients, with 3907 deliveries...
September 2015: Journal of Maternal-fetal & Neonatal Medicine
Yusuke Kondo, Tomoki Kikuchi, Joaquim Carreras Esteban, Nobue Kumaki, Go Ogura, Chie Inomoto, Kenichi Hirabayashi, Hiroshi Kajiwara, Akihiro Sakai, Ryousuke Sugimoto, Mitsunobu Otsuru, Kenji Okami, Keiichi Tsukinoki, Naoya Nakamura
Salivary duct carcinoma (SDC) is an aggressive adenocarcinoma of the salivary glands, and accounts for 1-3% of all malignant salivary gland tumors, resembling morphologically invasive ductal carcinoma (IDC) of the breast. In contrast to IDC of the breast and gastric carcinoma (GC), the study of human epidermal growth factor receptor 2 (HER2) in SDC has not progressed. Therefore, we investigated the relationship between HER2 protein expression and amplification of the HER2 gene, and compared them in terms of intratumoral heterogeneity (ITH) in 13 cases of SDC using immunohistochemistry and dual color in situ hybridization...
September 2014: Pathology International
Shigeo Horie, Shuichi Ito, Hirokazu Okada, Haruhito Kikuchi, Ichiei Narita, Tsutomu Nishiyama, Tomonori Hasegawa, Hiroshi Mikami, Kunihiro Yamagata, Tomoji Yuno, Satoru Muto
No abstract text is available yet for this article.
October 2014: Clinical and Experimental Nephrology
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