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https://www.readbyqxmd.com/read/29761117/genomic-analysis-identifies-masqueraders-of-full-term-cerebral-palsy
#1
Yusuke Takezawa, Atsuo Kikuchi, Kazuhiro Haginoya, Tetsuya Niihori, Yurika Numata-Uematsu, Takehiko Inui, Saeko Yamamura-Suzuki, Takuya Miyabayashi, Mai Anzai, Sato Suzuki-Muromoto, Yukimune Okubo, Wakaba Endo, Noriko Togashi, Yasuko Kobayashi, Akira Onuma, Ryo Funayama, Matsuyuki Shirota, Keiko Nakayama, Yoko Aoki, Shigeo Kure
Objective: Cerebral palsy is a common, heterogeneous neurodevelopmental disorder that causes movement and postural disabilities. Recent studies have suggested genetic diseases can be misdiagnosed as cerebral palsy. We hypothesized that two simple criteria, that is, full-term births and nonspecific brain MRI findings, are keys to extracting masqueraders among cerebral palsy cases due to the following: (1) preterm infants are susceptible to multiple environmental factors and therefore demonstrate an increased risk of cerebral palsy and (2) brain MRI assessment is essential for excluding environmental causes and other particular disorders...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29730616/study-protocol-for-the-g-spirit-trial-a-randomised-placebo-controlled-double-blinded-phase-iii-trial-of-granulocyte-colony-stimulating-factor-mediated-neuroprotection-for-acute-spinal-cord-injury
#2
Masao Koda, Hideki Hanaoka, Takatoshi Sato, Yasuhisa Fujii, Michiko Hanawa, Sho Takahashi, Takeo Furuya, Yasushi Ijima, Junya Saito, Mitsuhiro Kitamura, Seiji Ohtori, Yukei Matsumoto, Tetsuya Abe, Kei Watanabe, Toru Hirano, Masayuki Ohashi, Hirokazu Shoji, Tatsuki Mizouchi, Ikuko Takahashi, Norio Kawahara, Masahito Kawaguchi, Yugo Orita, Takeshi Sasamoto, Masahito Yoshioka, Masafumi Fujii, Katsutaka Yonezawa, Daisuke Soma, Hiroshi Taneichi, Daisaku Takeuchi, Satoshi Inami, Hiroshi Moridaira, Haruki Ueda, Futoshi Asano, Yosuke Shibao, Ikuo Aita, Yosuke Takeuchi, Masaya Mimura, Jun Shimbo, Yukio Someya, Sumio Ikenoue, Hiroaki Sameda, Kan Takase, Yoshikazu Ikeda, Fumitake Nakajima, Mitsuhiro Hashimoto, Tomoyuki Ozawa, Fumio Hasue, Takayuki Fujiyoshi, Koshiro Kamiya, Masahiko Watanabe, Hiroyuki Katoh, Yukihiro Matsuyama, Yu Yamamoto, Daisuke Togawa, Tomohiko Hasegawa, Sho Kobayashi, Go Yoshida, Shin Oe, Tomohiro Banno, Hideyuki Arima, Koji Akeda, Eiji Kawamoto, Hiroshi Imai, Toshihiko Sakakibara, Akihiro Sudo, Yasuo Ito, Tsuyoshi Kikuchi, Shuhei Osaki, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Shinji Kotaka, Hideo Baba, Tsuyoshi Okudaira, Hiroaki Konishi, Takayuki Yamaguchi, Keigo Ito, Yoshito Katayama, Taro Matsumoto, Tomohiro Matsumoto, Masaru Idota, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Toshimitsu Eto, Takehiro Sugaya, Michiharu Matsuda, Kazunari Fushimi, Satoshi Nozawa, Chizuo Iwai, Toshihiko Taguchi, Tsukasa Kanchiku, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Masashi Yamazaki
INTRODUCTION: Granulocyte colony-stimulating factor (G-CSF) is generally used for neutropaenia. Previous experimental studies revealed that G-CSF promoted neurological recovery after spinal cord injury (SCI). Next, we moved to early phase of clinical trials. In a phase I/IIa trial, no adverse events were observed. Next, we conducted a non-randomised, non-blinded, comparative trial, which suggested the efficacy of G-CSF for promoting neurological recovery. Based on those results, we are now performing a phase III trial...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29718797/cep250-mutations-associated-with-mild-cone-rod-dystrophy-and-sensorineural-hearing-loss-in-a-japanese-family
#3
Daiki Kubota, Kiyoko Gocho, Sachiko Kikuchi, Keiichiro Akeo, Masahiro Miura, Kunihiko Yamaki, Hiroshi Takahashi, Shuhei Kameya
BACKGROUND: CEP250 encodes the C-Nap1 protein which belongs to the CEP family of proteins. C-Nap1 has been reported to be expressed in the photoreceptor cilia and is known to interact with other ciliary proteins. Mutations of CEP250 cause atypical Usher syndrome which is characterized by early-onset sensorineural hearing loss (SNHL) and a relatively mild retinitis pigmentosa. This study tested the hypothesis that the mild cone-rod dystrophy (CRD) and SNHL in a non-consanguineous Japanese family was caused by CEP250 mutations...
May 2, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29660849/comparison-of-human-papillomavirus-genotyping-and-cytology-triage-compact-study-design-methods-and-baseline-results-in-14-642-women
#4
Satomi Aoyama-Kikawa, Hiromasa Fujita, Sharon J B Hanley, Mitsunori Kasamo, Kokichi Kikuchi, Toshihiko Torigoe, Yoshihiro Matsuno, Akiko Tamakoshi, Takayuki Sasaki, Motoki Matsuura, Yasuhito Kato, Peixin Dong, Hidemichi Watari, Tsuyoshi Saito, Kazuo Sengoku, Noriaki Sakuragi
Although cytology-based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplasia (CIN) and invasive cancer. However, the optimal triage strategy for HPV-positive women to avoid over-referral to colposcopy may be setting specific. As Japan requires data that have been generated domestically to modify screening guidelines, we conducted a 3-year prospective study, COMparison of HPV genotyping And Cytology Triage (COMPACT), to evaluate the potential role of HPV16/18 partial genotyping and cytology for primary HPV screening...
June 2018: Cancer Science
https://www.readbyqxmd.com/read/29445855/-treatment-strategy-for-early-stage-rectal-cancer-t1-carcinoma
#5
REVIEW
G Liebig-Hörl, C Puchner, M Gerken, M Klinkhammer-Schalke, A Fürst
BACKROUND: A common consensus for the definition for early rectal cancer does not exist. This item is used in cases of histological findings including pTis, pT1 or pT2 tumors. The term early rectal cancer is not mentioned in the German S3 guidelines on colorectal cancer. The pTis tumors are located at the mucosa level of the intestinal wall and they have nearly no tendency to develop metastases but pT2 tumors have a high risk of local metastases; therefore, the term early rectal cancer is not adequate for pT2 tumors...
February 14, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29362284/-endarterectomy-for-internal-carotid-artery-occlusion-with-an-aberrant-branch-of-the-internal-carotid-artery-maintaining-blood-flow-distal-to-the-complete-occlusion-a-case-report
#6
Shigeomi Yokoya, Hideki Oka, Asami Kikuchi, Youichi Hashimoto, Akihiko Hino
Doppler sonography accurately identifies occlusion of the internal carotid artery(ICA)and current surgical guidelines do not list an occluded ICA as an indication for carotid endarterectomy(CEA). We encountered an unusual case, for which we performed CEA. The left ICA was occluded by atherosclerosis, and was reconstituted via an aberrant branch of the occipital artery. A 71-year-old man was referred following brain infarction. Carotid duplex sonography(CDS)demonstrated occlusion of his left ICA, with flow in the distal ICA beyond the occlusion("Sandwich stump sign")...
January 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29246735/cardiac-arrest-in-pregnancy
#7
REVIEW
Jacqueline Kikuchi, Shad Deering
Cardiac arrest in pregnancy is a rare and frightening event. Although not every obstetrician will encounter cardiac arrest in pregnancy during their career, it is imperative to be prepared to manage this acute emergency. The management is particularly complex due to maternal physiologic changes from pregnancy and the simultaneous management of two patients, the mother and fetus. In 2010, the American Heart Association released their first scientific statement on guidelines for management of cardiac arrest in pregnancy that has since been updated in 2015...
February 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29093432/european-society-of-cardiology-esc-annual-congress-report-from-barcelona-2017
#8
Kimio Satoh, Jun Takahashi, Yasuharu Matsumoto, Shunsuke Tatebe, Tatsuo Aoki, Yoku Kikuchi, Kiyotaka Hao, Kazuma Ohyama, Masamichi Nogi, Akira Suda, Shintaro Kasahara, Koichi Sato, Sadamitsu Ichijo, Hiroaki Shimokawa
From August 26th to 30th, the 2017 Annual Congress of the European Society of Cardiology (ESC 2017) was held in Barcelona, Spain. Despite the terrorism tradegy just before the ESC congress, the congress attracted many medical professionals from all over the world to discuss the recent topics in cardiovascular medicine in more than 500 sessions, including COMPASS (Cardiovascular OutcoMes for People using Anticoagulation StrategieS Trial), CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study), and ORION (which assessed the effect of a novel siRNA inhibitor to PCSK9 on reductions in low-density lipoprotein cholesterol)...
November 24, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29053480/impact-of-moderate-intensity-and-vigorous-intensity-physical-activity-on-mortality
#9
Hiroyuki Kikuchi, Shigeru Inoue, I-Min Lee, Yuko Odagiri, Norie Sawada, Manami Inoue, Shoichiro Tsugane
PURPOSE: Physical activity guidelines recommend at least 150 min of moderate-intensity physical activity (MPA), 75 min of vigorous-intensity physical activity (VPA), or combination of MPA and VPA. However, few epidemiological studies have examined whether the general population can derive equal health benefits from MPA or VPA. This study examined the associations of different activity intensities with mortality. METHODS: In this prospective cohort study, a total of 83,454 community-dwelling Japanese who answered a questionnaire in 2000-2003 were followed for all-cause mortality through 2012...
April 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28954003/adherence-to-bclc-recommendations-for-the-treatment-of-hepatocellular-carcinoma-impact-on-survival-according-to-stage
#10
Luciana Kikuchi, Aline Lopes Chagas, Regiane S S M Alencar, Claudia Tani, Marcio A Diniz, Luiz A C D'Albuquerque, Flair José Carrilho
OBJECTIVES: This study sought to assess the adherence of newly diagnosed hepatocellular carcinoma patients to the Barcelona Clinic Liver Cancer system treatment guidelines and to examine the impact of adherence on the survival of patients in different stages of the disease. METHODS: This study included all patients referred for the treatment of hepatocellular carcinoma between 2010 and 2012. Patients (n=364) were classified according to the Barcelona Clinic Liver Cancer guidelines...
August 2017: Clinics
https://www.readbyqxmd.com/read/28549532/a-drop-system-for-prognostication-of-nhcap-inpatients
#11
Takeshi Koizumi, Hiroki Tsukada, Kazuhiko Ito, Satoshi Shibata, Satoshi Hokari, Takafumi Tetsuka, Nobumasa Aoki, Hiroshi Moro, Yoshinari Tanabe, Toshiaki Kikuchi
Nursing and healthcare-associated pneumonia (NHCAP) is a category of healthcare-associated pneumonia that was modified for the healthcare system of Japan. The NHCAP guidelines stated the difficulty in assessing the severity classifications, for instance, A-DROP. We compared the usefulness of different severity classifications (A-DROP, CURB-65, PSI, and I-ROAD) in predicting the prognosis of nursing and healthcare-associated pneumonia. We conducted a retrospective analysis on 303 adult patients hospitalized for nursing healthcare-associated pneumonia and community-acquired pneumonia, which were diagnosed at the Department of Respiratory Medicine of Niigata General City Hospital between January 2012 and December 2014...
August 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28464833/light-and-sporadic-physical-activity-overlooked-by-current-guidelines-makes-older-women-more-active-than-older-men
#12
Shiho Amagasa, Noritoshi Fukushima, Hiroyuki Kikuchi, Tomoko Takamiya, Koichiro Oka, Shigeru Inoue
BACKGROUND: Men are generally believed to be more physically active than women when evaluated using current physical activity (PA) guidelines, which count only moderate-to-vigorous physical activity (MVPA) in bouts lasting at least 10 min. However, it remains unclear men are truly more physically active provided that all-intensity PA are evaluated. This population based cross-sectional study aimed to examine gender differences in patterns of objectively-assessed PA in older adults. METHODS: One thousand two hundred ten community-dwelling Japanese older adults who were originally randomly selected from residential registry of three municipalities were asked to respond a questionnaire and wear an accelerometer (HJA-350IT, Omron Healthcare)...
May 2, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27350718/lifestyle-improvement-through-continuous-measurements-of-hemoglobin-a1c-levels-and-lifestyle-checks-at-the-community-pharmacy-in-three-cases
#13
Naoki Fujita, Nobuko Nabetani, Norimasa Umemura, Chigusa Kikuchi, Tadashi Suzuki
In this study, we took continuous measurements of hemoglobin A1c (HbA1c) levels and conducted lifestyle checks in three cases to determine if these parameters were effective in improving overall wellness. We selected three young men with relatively high HbA1c levels. During the 12-weeks study periods, we regularly measured each participant's HbA1c levels and monitored their lifestyle habits every two weeks at the community pharmacy once every 2 weeks using specific guidelines. The first participant, a 23-year-old man, had a HbA1c level of 5...
October 1, 2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27154308/report-of-a-nationwide-survey-on-actual-administered-radioactivities-of-radiopharmaceuticals-for-diagnostic-reference-levels-in-japan
#14
Hiroshi Watanabe, Kazunari Ishii, Makoto Hosono, Etsuko Imabayashi, Koichiro Abe, Masayuki Inubushi, Kazuko Ohno, Yasuhiro Magata, Kinya Ono, Kei Kikuchi, Kei Wagatsuma, Tadashi Takase, Kyoko Saito, Yasuyuki Takahashi
OBJECTIVE: The optimization of medical exposure is one of the major issues regarding radiation protection in the world, and The International Committee of Radiological Protection and the International Atomic Energy Agency recommend establishing diagnostic reference levels (DRLs) as tools for dose optimization. Therefore, the development of DRLs based on the latest survey has been required for nuclear medicine-related societies and organizations. This prompted us to conduct a nationwide survey on the actual administered radioactivity to adults for the purpose of developing DRLs in nuclear medicine...
July 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27052720/the-japanese-breast-cancer-society-clinical-practice-guidelines-for-screening-and-imaging-diagnosis-of-breast-cancer-2015-edition
#15
Mitsuhiro Tozaki, Yoshifumi Kuroki, Mari Kikuchi, Yasuyuki Kojima, Kazunori Kubota, Hiroshi Nakahara, Yoshinori Ito, Hirofumi Mukai
No abstract text is available yet for this article.
May 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27037772/predicting-changes-in-aquatic-toxicity-of-chemicals-resulting-from-solvent-or-dispersant-use-as-vehicle
#16
Mikio Kikuchi, Masamitsu Nakagawa, Suguru Tone, Hotaka Saito, Tatsuhiro Niino, Natsumi Nagasawa, Jun Sawai
The influence of two vehicles (N,N-dimethylformamide [DMF] as solvent and polyoxyethylene hydrogenated castor oil [HCO-40] as a dispersant) on the acute toxicity of eight hydrophobic chemicals with a non-specific mode of action to Daphnia magna was investigated according to the OECD Guidelines for the Testing of Chemicals, No. 202. An increased 48-h EC50 value for D. magna or reduced toxicity resulting from the addition of HCO-40 to the test medium was observed for five of the eight chemicals examined. Each of eight chemicals was dissolved in water at a concentration of either 10 mg/L or 1...
July 2016: Chemosphere
https://www.readbyqxmd.com/read/26604032/prognostic-impact-of-clinical-variables-on-surgically-resected-small-cell-lung-cancer-results-of-a-retrospective-multicenter-analysis-fight002a-and-hot1301a
#17
MULTICENTER STUDY
Hiroshi Yokouchi, Takashi Ishida, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Tatsuro Fukuhara, Kei Takamura, Tetsuya Kojima, Toshiyuki Harada, Mitsunori Higuchi, Yoshifumi Matsuura, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Hiroshi Nishihara, Hiroyuki Suzuki, Hirotoshi Dosaka-Akita, Hiroshi Isobe, Masaharu Nishimura, Mitsuru Munakata
OBJECTIVES: Several American and Japanese guidelines recommend surgery for patients with c-stage I small-cell lung cancer (SCLC), whereas the European Society of Medical Oncology (ESMO) guidelines recommend surgery for patients with not only c-stage I but also c-stage II (T2N1) SCLC. In addition, previous studies identified various factors other than clinical stage that are related to survival in these patients. Thus, further validation and examination of the association of clinical stage and other clinical variables with survival are required for establishing practical management of early-stage SCLC...
December 2015: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/26526670/effective-utilization-of-genetic-information-for-athletes-and-coaches-focus-on-actn3-r577x-polymorphism
#18
REVIEW
Naoki Kikuchi, Koichi Nakazato
Training variants (type, intensity, and duration of exercise) can be selected according to individual aims and fitness assessment. Recently, various methods of resistance and endurance training have been used for muscle hypertrophy and VO2max improvement. Although several genetic variants are associated with elite athletic performance and muscle phenotypes, genetic background has not been used as variant for physical training. ACTN3 R577X is a well-studied genetic polymorphism. It is the only genotype associated with elite athletic performance in multiple cohorts...
September 2015: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/26376349/recent-advances-from-basic-and-clinical-studies-of-esophageal-squamous-cell-carcinoma
#19
REVIEW
Shinya Ohashi, Shin'ichi Miyamoto, Osamu Kikuchi, Tomoyuki Goto, Yusuke Amanuma, Manabu Muto
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive squamous cell carcinomas and is highly prevalent in Asia. Alcohol and its metabolite, acetaldehyde, are considered definite carcinogens for the esophagus. Polymorphisms in the aldehyde dehydrogenase 2 gene, which encodes an enzyme that eliminates acetaldehyde, have been associated with esophageal carcinogenesis. Studies of the mutagenic and carcinogenic effects of acetaldehyde support this observation. Several recent large-scale comprehensive analyses of the genomic alterations in ESCC have shown a high frequency of mutations in genes such as TP53 and others that regulate the cell cycle or cell differentiation...
December 2015: Gastroenterology
https://www.readbyqxmd.com/read/26019400/treatment-situation-of-male-hypogonadotropic-hypogonadism-in-pediatrics-and-proposal-of-testosterone-and-gonadotropins-replacement-therapy-protocols
#20
Naoko Sato, Tomonobu Hasegawa, Yukihiro Hasegawa, Osamu Arisaka, Keiichi Ozono, Shin Amemiya, Toru Kikuchi, Hiroyuki Tanaka, Shohei Harada, Ichiro Miyata, Toshiaki Tanaka
Male hypogonadotropic hypogonadism (MHH), a disorder associated with infertility, is treated with testosterone replacement therapy (TRT) and/or gonadotropins replacement therapy (GRT) (TRT and GRT, together with HRT hormone replacement therapy). In Japan, guidelines have been set for treatment during adolescence. Due to the risk of rapid maturation of bone age, low doses of testosterone or gonadotropins have been used. However, the optimal timing and methods of therapeutic intervention have not yet been established...
April 2015: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
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