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recurrence malaria quinine

Pauline Byakika-Kibwika, Jane Achan, Mohammed Lamorde, Carine Karera-Gonahasa, Agnes N Kiragga, Harriet Mayanja-Kizza, Noah Kiwanuka, Sam Nsobya, Ambrose O Talisuna, Concepta Merry
BACKGROUND: Severe malaria is a medical emergency associated with high mortality. Adequate treatment requires initial parenteral therapy for fast parasite clearance followed by longer acting oral antimalarial drugs for cure and prevention of recrudescence. METHODS: In a randomized controlled clinical trial, we evaluated the 42-day parasitological outcomes of severe malaria treatment with intravenous artesunate (AS) or intravenous quinine (QNN) followed by oral artemisinin based combination therapy (ACT) in children living in a high malaria transmission setting in Eastern Uganda...
December 28, 2017: BMC Infectious Diseases
Makoto Saito, Mary Ellen Gilder, François Nosten, Rose McGready, Philippe J Guérin
BACKGROUND: There is no agreed standard method to assess the efficacy of anti-malarials for uncomplicated falciparum in pregnancy despite an increased risk of adverse outcomes for the mother and the fetus. The aim of this review is to present the currently available evidence from both observational and interventional cohort studies on anti-malarial efficacy in pregnancy and summarize the variability of assessment and reporting found in the review process. METHODS: Efficacy methodology and assessment of artemisinin-based treatments (ABT) and quinine-based treatments (QBT) were reviewed systematically using seven databases and two clinical trial registries (protocol registration-PROSPERO: CRD42017054808)...
December 13, 2017: Malaria Journal
Meththananda Herath Herath Mudiyanselage, Nayani Prasangika Weerasinghe, Kithsiri Pathirana, Hasini Dias
BACKGROUND: Cerebral malaria is arguably one of the most common non-traumatic encephalopathies in the developing world. Unless the diagnosis of cerebral malaria is made promptly, the consequence could be disastrous. Even though the diagnosis of cerebral malaria can be made relatively easily in majority of cases atypical presentation can often lead to misdiagnosis or delayed diagnosis. We report a case of an uncommon presentation of Plasmodium falciparum infection in a 17-year-old school girl with altered sensorium, seizures and phobic spasms...
August 11, 2016: BMC Research Notes
Kerryn A Moore, Julie A Simpson, Moo Kho Paw, MuPawJay Pimanpanarak, Jacher Wiladphaingern, Marcus J Rijken, Podjanee Jittamala, Nicholas J White, Freya J I Fowkes, François Nosten, Rose McGready
BACKGROUND: Artemisinins, the most effective antimalarials available, are not recommended for falciparum malaria during the first trimester of pregnancy because of safety concerns. Therefore, quinine is used despite its poor effectiveness. Assessing artemisinin safety requires weighing the risks of malaria and its treatment. We aimed to assess the effect of first-trimester malaria and artemisinin treatment on miscarriage and major congenital malformations. METHODS: In this observational study, we assessed data from antenatal clinics on the Thai-Myanmar border between Jan 1, 1994, and Dec 31, 2013...
May 2016: Lancet Infectious Diseases
Katherine Plewes, Richard J Maude, Aniruddha Ghose, Arjen M Dondorp
BACKGROUND: Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mucormycosis in a previously healthy adult male. CASE PRESENTATION: A 30-year old Bangladeshi man was admitted with severe falciparum malaria complicated by hyperlactataemia and haemoglobinuria...
2015: BMC Infectious Diseases
Marc C Tahita, Halidou Tinto, Sibiri Yarga, Adama Kazienga, Maminata Traore Coulibaly, Innocent Valea, Chantal Van Overmeir, Anna Rosanas-Urgell, Jean-Bosco Ouedraogo, Robert T Guiguemde, Jean-Pierre van Geertruyden, Annette Erhart, Umberto D'Alessandro
BACKGROUND: Ex vivo assays are usually carried out on parasite isolates collected from patients with uncomplicated Plasmodium falciparum malaria, from which pregnant women are usually excluded as they are often asymptomatic and with relatively low parasite densities. Nevertheless, P. falciparum parasites infecting pregnant women selectively sequester in the placenta and may have a different drug sensitivity profile compared to those infecting other patients. The drug sensitivity profile of P...
June 20, 2015: Malaria Journal
Natthapon Laochan, Sophie G Zaloumis, Mallika Imwong, Usa Lek-Uthai, Alan Brockman, Kanlaya Sriprawat, Jacher Wiladphaingern, Nicholas J White, François Nosten, Rose McGready
BACKGROUND: Plasmodium falciparum infections adversely affect pregnancy. Anti-malarial treatment failure is common. The objective of this study was to examine the duration of persistent parasite carriage following anti-malarial treatment in pregnancy. METHODS: The data presented here are a collation from previous studies carried out since 1994 in the Shoklo Malaria Research Unit (SMRU) on the Thailand-Myanmar border and performed using the same unique methodology detailed in the Materials and Methods section...
May 28, 2015: Malaria Journal
Patrick Tumwebaze, Melissa D Conrad, Andrew Walakira, Norbert LeClair, Oswald Byaruhanga, Christine Nakazibwe, Benjamin Kozak, Jessica Bloome, Jaffer Okiring, Abel Kakuru, Victor Bigira, James Kapisi, Jennifer Legac, Jiri Gut, Roland A Cooper, Moses R Kamya, Diane V Havlir, Grant Dorsey, Bryan Greenhouse, Samuel L Nsobya, Philip J Rosenthal
Changing treatment practices may be selecting for changes in the drug sensitivity of malaria parasites. We characterized ex vivo drug sensitivity and parasite polymorphisms associated with sensitivity in 459 Plasmodium falciparum samples obtained from subjects enrolled in two clinical trials in Tororo, Uganda, from 2010 to 2013. Sensitivities to chloroquine and monodesethylamodiaquine varied widely; sensitivities to quinine, dihydroartemisinin, lumefantrine, and piperaquine were generally good. Associations between ex vivo drug sensitivity and parasite polymorphisms included decreased chloroquine and monodesethylamodiaquine sensitivity and increased lumefantrine and piperaquine sensitivity with pfcrt 76T, as well as increased lumefantrine sensitivity with pfmdr1 86Y, Y184, and 1246Y...
2015: Antimicrobial Agents and Chemotherapy
Encouse B Golden, Hee-Yeon Cho, Florence M Hofman, Stan G Louie, Axel H Schönthal, Thomas C Chen
OBJECT: Chloroquine (CQ) is a quinoline-based drug widely used for the prevention and treatment of malaria. More recent studies have provided evidence that this drug may also harbor antitumor properties, whereby CQ possesses the ability to accumulate in lysosomes and blocks the cellular process of autophagy. Therefore, the authors of this study set out to investigate whether CQ analogs, in particular clinically established antimalaria drugs, would also be able to exert antitumor properties, with a specific focus on glioma cells...
March 2015: Neurosurgical Focus
Asım Ülçay, Gökhan Karaahmetoğlu, Vedat Turhan, Hakan Erdem, Ali Acar, Oral Öncül, Levent Görenek
Malaria is a parasitic infection characterized by anemia, splenomegaly and periodic fever. This infection has a tendency to cause serious complications. Falciparum malaria could occur in our country as an imported case due to increasing intercontinental travel opportunities. The World Health Organisation (WHO) recommends arthemether combination treatment as a first line choice. Here we report a Turkish case admitted to the hospital with high fever, sweating and fatigue. He had been in Uganda for 6 months without prophylaxis...
2014: Türkiye Parazitolojii Dergisi
Jeanne Rini Poespoprodjo, Wendy Fobia, Enny Kenangalem, Daniel A Lampah, Paulus Sugiarto, Emiliana Tjitra, Nicholas M Anstey, Ric N Price
BACKGROUND: Artemisinin combination therapy (ACT) is recommended for the treatment of multidrug resistant malaria in the second and third trimesters of pregnancy, but the experience with ACTs is limited. We review the exposure of pregnant women to the combination dihydroartemisinin-piperaquine over a 6 year period. METHODS: From April 2004-June 2009, a prospective hospital-based surveillance screened all pregnant women for malaria and documented maternal and neonatal outcomes...
2014: PloS One
Sabina Dahlström, Agnès Aubouy, Oumou Maïga-Ascofaré, Jean-François Faucher, Abel Wakpo, Sèm Ezinmègnon, Achille Massougbodji, Pascal Houzé, Eric Kendjo, Philippe Deloron, Jacques Le Bras, Sandrine Houzé
Artemisinin-based combination therapies (ACTs) are the main option to treat malaria, and their efficacy and susceptibility must be closely monitored to avoid resistance. We assessed the association of Plasmodium falciparum polymorphisms and ex vivo drug susceptibility with clinical effectiveness. Patients enrolled in an effectiveness trial comparing artemether-lumefantrine (n = 96), fixed-dose artesunate-amodiaquine (n = 96), and sulfadoxine-pyrimethamine (n = 48) for the treatment of uncomplicated malaria 2007 in Benin were assessed...
2014: Antimicrobial Agents and Chemotherapy
Hypolite Muhindo Mavoko, Carolyn Nabasumba, Halidou Tinto, Umberto D'Alessandro, Martin Peter Grobusch, Pascal Lutumba, Jean-Pierre Van Geertruyden
BACKGROUND: Artemisinin-based combination therapy is currently recommended by the World Health Organization as first-line treatment of uncomplicated malaria. Recommendations were adapted in 2010 regarding rescue treatment in case of treatment failure. Instead of quinine monotherapy, it should be combined with an antibiotic with antimalarial properties; alternatively, another artemisinin-based combination therapy may be used. However, for informing these policy changes, no clear evidence is yet available...
September 23, 2013: Trials
Adoke Yeka, James Tibenderana, Jane Achan, Umberto D'Alessandro, Ambrose O Talisuna
BACKGROUND: The treatment of falciparum malaria poses unique challenges in settings where malaria transmission intensity is high because recurrent infections are common. These could be new infections, recrudescences, or a combination of the two. Though several African countries continue to use quinine as the second line treatment for patients with recurrent infections, there is little information on its efficacy when used for rescue therapy. Moreover, such practice goes against the World Health Organisation (WHO) recommendation to use combination therapy for uncomplicated malaria...
2013: PloS One
Inge Sutanto, Bagus Tjahjono, Hasan Basri, W Robert Taylor, Fauziah A Putri, Rizka A Meilia, Rianto Setiabudy, Siti Nurleila, Lenny L Ekawati, Iqbal Elyazar, Jeremy Farrar, Herawati Sudoyo, J Kevin Baird
Radical cure of Plasmodium vivax infection applies blood schizontocidal therapy against the acute attack and hypnozoitocidal therapy against later relapse. Chloroquine and primaquine have been used for 60 years in this manner. Resistance to chloroquine by the parasite now requires partnering other blood schizontocides with primaquine. However, the safety and efficacy of primaquine against relapse when combined with other drugs have not been demonstrated. This randomized, open-label, and relapse-controlled trial estimated the efficacy of primaquine against relapse when administered with quinine or dihydroartemisinin-piperaquine for treatment of the acute infection...
March 2013: Antimicrobial Agents and Chemotherapy
Angela Corpolongo, Pasquale De Nardo, Piero Ghirga, Elisa Gentilotti, Rita Bellagamba, Chiara Tommasi, Maria Grazia Paglia, Emanuele Nicastri, Pasquale Narciso
Intravenous (i.v.) artesunate is now the recommended first-line treatment of severe falciparum malaria in adults and children by WHO guidelines. Nevertheless, several cases of haemolytic anaemia due to i.v. artesunate treatment have been reported. This paper describes the case of an HIV-infected patient with severe falciparum malaria who was diagnosed with haemolytic anaemia after treatment with oral artemether-lumefantrine.The patient presented with fever, headache, and arthromyalgia after returning from Central African Republic where he had been working...
March 27, 2012: Malaria Journal
Gabriele Franken, Irmela Müller-Stöver, Martha C Holtfreter, Susanne Walter, Heinz Mehlhorn, Alfons Labisch, Dieter Häussinger, Joachim Richter
Quartan malaria due to Plasmodium malariae is commonly regarded as being preventable by current antimalarials. A case of P. malariae infection occurred in spite of previous treatment of Plasmodium falciparum malaria 4 months earlier with a full therapy course of intravenous quinine hydrochloride and oral doxycycline followed by artemether + lumefantrine. Since the patient was not anymore exposed to agents of malaria in the meantime, a new infection by P. malariae after therapy is unlikely. The present observation is difficult to explain by the current view on the origin of latent P...
August 2012: Parasitology Research
A Bignami
No abstract text is available yet for this article.
December 2010: Parassitologia
Harald Noedl, Youry Se, Sabaithip Sriwichai, Kurt Schaecher, Paktiya Teja-Isavadharm, Bryan Smith, Wiriya Rutvisuttinunt, Delia Bethell, Sittidech Surasri, Mark M Fukuda, Duong Socheat, Lon Chan Thap
BACKGROUND: Increasing rates of failure of artemisinin-based combination therapy have highlighted the possibility of emerging artemisinin resistance along the Thai-Cambodian border. We used an integrated in vivo-in vitro approach to assess the presence of artemisinin resistance in western Cambodia. This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine. METHODS: Ninety-four adult patients from Battambang Province, western Cambodia, who presented with uncomplicated falciparum malaria were randomized to receive high-dose artesunate therapy (4 mg/kg/day orally for 7 days) or quinine-tetracycline...
December 1, 2010: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Teferi Eshetu, Nicole Berens-Riha, Sintayehu Fekadu, Zelalem Tadesse, Robert Gürkov, Michael Hölscher, Thomas Löscher, Isabel Barreto Miranda
BACKGROUND: The emergence of drug resistance is a major problem in malaria control. Combination of molecular genotyping and characterization of mutations or single nucleotide polymorphisms (SNPs) correlated with drug resistance can provide information for subsequent surveillance of existing and developing drug resistance patterns. The introduction of artemether/lumefantrine (AL) as first-line treatment, never used before in Ethiopia, allowed the collection of baseline data of molecular polymorphisms before a selection due to AL could occur...
August 7, 2010: Malaria Journal
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