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https://www.readbyqxmd.com/read/28445855/speed-dependent-effects-of-laterally-wedged-insoles-on-gait-biomechanics-in-healthy-subjects
#1
Felix Kluge, Sebastian Krinner, Matthias Lochmann, Bjoern M Eskofier
Laterally wedged insoles have been shown to be effective for the reduction of the knee adduction moment and other biomechanical variables that are associated with the pathogenesis of knee osteoarthritis. However, inconclusive results such as adverse effects in individual subjects or even no group-wise wedge effects have been presented in different studies and it has been suggested to identify variables that potentially confound the wedge effect. The main objective of this study was the investigation of interaction effects of lateral wedges with walking speed, as different self-selected speeds have mainly been used in previous studies...
April 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28445709/gait-analysis-and-weight-bearing-in-pre-clinical-joint-pain-research
#2
Kristina Ängeby Möller, Heta Svärd, Anni Suominen, Jarmo Immonen, Johanna Holappa, Carina Stenfors
BACKGROUND: There is a need for better joint pain treatment, but development of new medication has not been successful. Pre-clinical models with readouts that better reflect the clinical situation are needed. In patients with joint pain, pain at rest and pain at walking are two major complaints. NEW METHOD: We describe a new way of calculating results from gait analysis using the CatWalk™ setup. Rats with monoarthritis induced by injection of Complete Freund's Adjuvant (CFA) intra-articularly into the ankle joint of one hind limb were used to assess gait and dynamic weight bearing...
April 23, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28445658/a-time-and-a-place-for-everything-phylogenetic-history-and-geography-as-joint-predictors-of-oak-plastome-phylogeny
#3
Kasey Khanh Pham, Andrew L Hipp, Paul S Manos, Richard C Cronn
Due to high rates of introgressive hybridization, the plastid genome is poorly suited to fine-scale DNA barcoding and phylogenetic studies of the oak genus (Quercus, Fagaceae). At the tips of the oak plastome phylogeny, recent gene migration and reticulation generally cause topology to reflect geographic structure, while deeper branches reflect lineage divergence. In this study, we quantify the simple and partial effects of geographic proximity and nucleome-inferred phylogenetic history on oak plastome phylogeny at different evolutionary scales...
April 26, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28445495/pharmacokinetic-and-pharmacodynamic-modelling-after-subcutaneous-intravenous-and-buccal-administration-of-a-high-concentration-formulation-of-buprenorphine-in-conscious-cats
#4
Graeme M Doodnaught, Beatriz P Monteiro, Javier Benito, Daniel Edge, Francis Beaudry, Ludovic Pelligand, Paulo Steagall
BACKGROUND: The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats. METHODS: Six healthy cats (4.9 ± 0.7 kg) were included in a prospective, randomized, blinded, crossover study. Simbadol™ (1.8 mg mL-1) was administered by the subcutaneous (SC; 0.24 mg kg-1), intravenous (IV; 0.12 mg kg-1) or buccal (OTM; 0.12 mg kg-1) route of administration and thermal thresholds (TT) were compared with a saline group (SAL)...
2017: PloS One
https://www.readbyqxmd.com/read/28445434/an-adaptive-clustering-approach-based-on-minimum-travel-route-planning-for-wireless-sensor-networks-with-a-mobile-sink
#5
Jiqiang Tang, Wu Yang, Lingyun Zhu, Dong Wang, Xin Feng
In recent years, Wireless Sensor Networks with a Mobile Sink (WSN-MS) have been an active research topic due to the widespread use of mobile devices. However, how to get the balance between data delivery latency and energy consumption becomes a key issue of WSN-MS. In this paper, we study the clustering approach by jointly considering the Route planning for mobile sink and Clustering Problem (RCP) for static sensor nodes. We solve the RCP problem by using the minimum travel route clustering approach, which applies the minimum travel route of the mobile sink to guide the clustering process...
April 26, 2017: Sensors
https://www.readbyqxmd.com/read/28445369/a-systematic-review-of-different-implants-and-approaches-for-proximal-interphalangeal-joint-arthroplasty
#6
Michiro Yamamoto, Sunitha Malay, Yuki Fujihara, Lin Zhong, Kevin C Chung
BACKGROUND: Outcomes after implant arthroplasty for primary degenerative and posttraumatic osteoarthritis of the proximal interphalangeal joint were different according to the implant design and surgical approach. The purpose of this systematic review was to evaluate outcomes of various types of implant arthroplasty for proximal interphalangeal joint osteoarthritis, with an emphasis on different surgical approaches. METHODS: The authors searched all available literature in the PubMed and EMBASE databases for articles reporting on outcomes of implant arthroplasty for proximal interphalangeal joint osteoarthritis...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445306/the-efficacy-and-safety-of-epinephrine-for-postoperative-bleeding-in-total-joint-arthroplasty-a-prisma-compliant-meta-analysis
#7
Yanbin Teng, Jianxiong Ma, Xinlong Ma, Ying Wang, Bin Lu, Chaowei Guo
BACKGROUND: Total joint arthroplasty (TJA) usually results in postoperative bleeding. Some randomized controlled trials (RCTs) and nonrandomized controlled trials (non-RCTs) have been performed to evaluate the effects of epinephrine on postoperative bleeding after TJA. However, this remained controversial about the efficacy and safety of epinephrine for postoperative bleeding in TJA. The objective of our meta-analysis was to compare the overall effect and safety of epinephrine and placebo for postoperative bleeding in TJA...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445298/barcelona-clinic-liver-cancer-stage-c-hepatocellular-carcinoma-a-novel-approach-to-subclassification-and-treatment
#8
Chung Hwan Jun, Jae Hyun Yoon, Eunae Cho, Sang Soo Shin, Sung Bum Cho, Hee Joon Kim, Chang Hwan Park, Hyun Soon Kim, Sung Kyu Choi, Jong Sun Rew
Barcelona clinic liver cancer-stage C (BCLC-C) encompasses a broad spectrum of tumor burdens, liver function statuses, patient prognoses, and treatment strategies. Currently, sorafenib is the only recommended treatment for patients with BCLC-C and outcomes remain suboptimal. The aims of this study were to assess the heterogeneity of BCLC-C hepatocellular carcinoma (HCC) cases, propose a novel subclassification for these cases, and suggest optimal treatment strategies other than sorafenib.We retrospectively analyzed 196 consecutive BCLC-C HCC patients who were diagnosed and treated between January 2008 and December 2015...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445271/identifying-pretreatment-baseline-factors-predictive-of-distant-metastasis-in-patients-with-nasopharyngeal-carcinoma-after-radiotherapy
#9
Yu Wang, Guojian Chen
This retrospective study was performed to identify pretreatment baseline factors that could predict the development of distant metastasis (DM) in patients with nasopharyngeal carcinoma (NPC).A cohort of 119 NPC patients undergoing radiotherapy (RT) or chemoradiotherapy (CRT) were recruited into the study. Among them, 51 developed DM (DM group) within 3 years after treatment and 68 did not (DM-free group). Various clinicopathological factors were measured before the treatment and analyzed by univariate as well as multivariate analyses for the potential correlation with DM development...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445008/prevalence-of-complement-mediated-cell-lysis-like-gene-sicg-in-streptococcus-dysgalactiae-subsp-equisimilis-isolates-from-japan-2014-2016
#10
Takashi Takahashi, Tomohiro Fujita, Akiyoshi Shibayama, Yuzo Tsuyuki, Haruno Yoshida
BACKGROUND: Streptococcus dysgalactiae subsp. equisimilis (SDSE; a β-hemolytic streptococcus of human or animal origin) infections are emerging worldwide. We evaluated the clonal distribution of complement-mediated cell lysis-like gene (sicG) among SDSE isolates from three central prefectures of Japan. METHODS: Group G/C β-hemolytic streptococci were collected from three institutions from April 2014 to March 2016. Fifty-five strains (52 from humans and three from animals) were identified as SDSE on the basis of 16S rRNA sequencing data...
July 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28444666/markers-of-bone-and-cartilage-turnover
#11
Henning W Woitge, Markus J Seibel
Over the past few decades, scientists have been trying to identify tissue-specific markers that would help to better understand the pathogenesis of bone and cartilage diseases and could be used clinically for the screening, diagnosis and follow-up of bone or joint diseases. Historically, only a few components known to be involved in bone, mineral or cartilage turnover were available for this purpose (e. g., urine hydroxyproline, serum and urine calcium and phosphate levels). However, since most if not all of these substances have wider biological functions beyond bone, mineral and cartilage metabolism, their clinical value as tissue-specific markers was limited...
April 25, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28444652/-establishment-of-specialized-pediatric-palliative-home-care-in-the-medical-valley-of-the-european-metropolitan-area-nuremberg
#12
Steven Hébert, Chara Gravou-Apostolatou, Wolfgang Rascher
Background As part of the 2007 health reform in Germany the structure of outpatient palliative care for children and adolescents was adopted for the first time and then implemented in Erlangen-Nuremberg in 2009. Methods The introduction of Pediatric Palliative Home Care (PPHC) at the Hospital for Children and Adolescents at the University of Erlangen-Nuremberg was retrospectively analyzed between the years 2009 to 2014. Referring medical records (paper-based and electronic) were evaluated systematically. Results Considering 69 patients within this study, 44 (63...
March 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28444650/-newborn-screening-on-cystic-fibrosis-in-germany-comparison-of-the-new-screening-protocol-with-an-alternative-protocol
#13
Olaf Sommerburg, Mirjam Stahl, Jutta Hammermann, Jürgen G Okun, Andreas Kulozik, Georg Hoffmann, Marcus Mall
Background For the new cystic fibrosis (CF) newborn screening program in Germany the Federal Joint Committee (G-BA) implemented a new screening protocol using immunoreactive trypsinogen (IRT) as first and pancreatitis associated protein (PAP) as second tier. Gene analysis with a panel of 31 CFTR-mutations is used as third tier to increase the positive predictive value (PPV) which is known to be low in pure biochemical IRT/PAP protocols. Methods For post hoc analysis the data pool (n=372 906) of a study evaluating a pure biochemical IRT/PAP protocol was used for assessment of the 3-step G-BA protocol in comparison with an alternative screening protocol recommended by the authors...
March 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28444454/influence-of-the-contralateral-hip-state-after-total-hip-arthroplasty-on-patient-reported-outcomes-measured-with-the-forgotten-joint-score-12
#14
Mikio Matsumoto, Tomonori Baba, Hironori Ochi, Yu Ozaki, Taiji Watari, Yasuhiro Homma, Kazuo Kaneko
PURPOSE: The purpose of this study was to examine the influence of the contralateral hip state on postoperative assessment using the Forgotten Joint Score-12 (FJS-12) in comparison with the McMaster Universities Osteoarthritis Index (WOMAC) and the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ). METHODS: One hundred and thirty-four hips underwent total hip arthroplasty (THA) between 2014 and 2015. Of these, the subjects were 106 hips with degenerative hip arthrosis as a primary disease for whom initial THA was performed on the affected side...
April 25, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28444244/cochrane-review-identifies-safe-and-effective-treatment-for-z-joint-pain
#15
Byron J Schneider, David C Miller, Kevin R Martinez, Alan Gonzalez Cota, Marc K Maes
No abstract text is available yet for this article.
April 24, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28444208/adverse-impacts-of-chronic-pain-on-health-related-quality-of-life-work-productivity-depression-and-anxiety-in-a-community-based-study
#16
Kosuke Kawai, Alison Tse Kawai, Peter Wollan, Barbara P Yawn
Background.: Chronic pain has major clinical and social consequences. Few studies have examined any variation in the extent of impairment on quality of life and work productivity by site and type of chronic pain. Objective.: The objective of our study is to examine adverse impacts of chronic pain on physical and psychological health and work productivity. Methods.: Our community-population study was based on a phone-interview of adults with chronic pain, residing in Olmsted County, MN...
April 22, 2017: Family Practice
https://www.readbyqxmd.com/read/28443622/the-rudy-study-using-digital-technologies-to-enable-a-research-partnership
#17
Harriet J A Teare, Joanna Hogg, Jane Kaye, Raashid Luqmani, Elaine Rush, Alison Turner, Laura Watts, Melanie Williams, M Kassim Javaid
Patients have extensive experience of their disease that can enhance the design and execution of research leading to significant innovations and efficiencies in the research process. The research community on the whole have been slow to adopt practices that enable patients to become active partners in research. Digital technologies are providing the means to do this more easily and so are increasingly being used to interact with patients and involve them in the design and execution of research. The RUDY (Rare UK Diseases of bone, joints and blood vessels) study's pioneering approach applies a custom-developed electronic platform where patients can contribute information over time about their disease experience, lifestyle and clinical history...
April 26, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28443578/the-hyoid-bone-and-thyroid-cartilage-metastases-from-the-sigmoid-colon-adenocarcinoma-a-case-report
#18
Djurdja Bracanovic, Vesna Vukovic, Aleksa Janovic, Davorin Radosavljevic, Zoran Rakocevic
BACKGROUND: Secondary tumors of the hyoid bone and thyroid cartilage are extremely rare. In this paper, we presented a case of the hyoid bone and thyroid cartilage metastases in patient treated for the sigmoid colon adenocarcinoma. CASE REPORT: Four years after sigmoid colon adenocarcinoma was diagnosed and treated with surgery and chemotherapy, the patient developed bone metastases in left sacroiliac joint and right proximal humerus. Although patient didn't complain of any related symptom, in bone scintigraphy accumulation of Technetium-99m was incidentally detected in the two sites of the anterior neck...
April 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443571/numerical-optimization-of-the-position-in-femoral-head-of-proximal-locking-screws-of-proximal-femoral-nail-system-biomechanical-study
#19
Mehmet Nuri Konya, Özgür Verim
BACKGROUND: Proximal femoral fracture rates are increasing due to osteoporosis and traffic accident. Proximal femoral nails are routinely used in the treatment of these fractures on the proximal femur. AIMS: The present study aimed to compare various combination and to determine ideal proximal lag screw (PLS) position on the pertrochanteric fractures (AO classification 31-A1) of femur by using optimised finite element analysis. STUDY DESIGN: Biomechanical Study...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443512/clinical-and-radiographic-features-of-knee-osteoarthritis-of-elderly-patients
#20
Hana Sahli, Aicha Ben Tekaya, Selim Daas, Ines Mahmoud, Rawdha Tekaya
BACKGROUND: Knee osteoarthritis is a common pathology, characterized by a prevalence that increases with age. Absence of anatomo-clinical correlation its management complex, particularly in a geriatric setting where it is not well studied. OBJECTIVE: The aim of the present study is to investigate the epidemio-clinical profile, functional impairment and radiographic features of knee osteoarthritis in the old patients versus younger patients (<65 years). METHODS: Cross-sectional study including patients who were monitored for 6 months at a rheumatology department for knee osteoarthritis...
April 25, 2017: Current Rheumatology Reviews
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