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Elective PCI

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https://www.readbyqxmd.com/read/28104204/randomized-comparison-of-oral-p2y12-receptor-inhibitor-loading-strategies-for-transitioning-from-cangrelor-the-excelsiorload2-trial
#1
Willibald Hochholzer, Pascal Kleiner, Iris Younas, Christian M Valina, Nikolaus Löffelhardt, Michael Amann, Timo Bömicke, Miroslaw Ferenc, Dieter Hauschke, Dietmar Trenk, Franz-Josef Neumann, Christian Stratz
OBJECTIVES: This randomized trial tested whether early loading with prasugrel can provide sufficient platelet inhibition even when given at the start of a 2-h infusion of cangrelor. BACKGROUND: Effective platelet inhibition with intravenous cangrelor reduces the risk of ischemic complications during percutaneous coronary intervention (PCI). Transitioning to oral therapy with clopidogrel or prasugrel is only recommended after discontinuation of cangrelor due to drug interactions...
January 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28100874/efficacy-of-multidetector-computed-tomography-to-predict-periprocedural-myocardial-injury-after-percutaneous-coronary-intervention-for-chronic-total-occlusion
#2
Eisuke Usui, Tetsumin Lee, Tadashi Murai, Yoshihisa Kanaji, Junji Matsuda, Makoto Araki, Taishi Yonetsu, Yosuke Yamakami, Shigeki Kimura, Tsunekazu Kakuta
Specific signatures of culprit lesions detected on multidetector computed tomography (MDCT) were identified as predictors of periprocedural myocardial injury (PMI) after percutaneous coronary intervention (PCI) in patients with stable angina; PMI has been shown to be associated with a worse prognosis. We investigated the association between preprocedural culprit lesion characteristics, assessed by MDCT, and PMI after PCI for chronic total occlusion (CTO). From three medical centers, 81 patients who underwent pre-PCI MDCT and CTO PCI, and systematic cardiac troponin (cTn) sampling before and after PCI, were included...
January 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28097639/risk-of-bleeding-and-repeated-bleeding-events-in-prasugrel-treated-patients-a-review-of-data-from-the-japanese-prasfit-studies
#3
REVIEW
Masakatsu Nishikawa, Takaaki Isshiki, Takeshi Kimura, Hisao Ogawa, Hiroyoshi Yokoi, Shunichi Miyazaki, Yasuo Ikeda, Masato Nakamura, Yuko Tanaka, Shigeru Saito
Prasugrel is a third-generation thienopyridine that achieves potent platelet inhibition with less pharmacological variability than other thienopyridines. However, clinical experience suggests that prasugrel may be associated with a higher risk of de novo and recurrent bleeding events compared with clopidogrel in Japanese patients undergoing percutaneous coronary intervention (PCI). In this review, we evaluate the risk of bleeding in Japanese patients treated with prasugrel at the doses (loading/maintenance doses: 20/3...
January 17, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28077227/impact-of-nutritional-assessment-and-body-mass-index-on-cardiovascular-outcomes-in-patients-with-stable-coronary-artery-disease
#4
Ayako Kunimura, Hideki Ishii, Tadayuki Uetani, Toshijirou Aoki, Kazuhiro Harada, Kenshi Hirayama, Yosuke Negishi, Yohei Shibata, Takuya Sumi, Kazuhiro Kawashima, Yosuke Tatami, Toshiki Kawamiya, Dai Yamamoto, Susumu Suzuki, Tetsuya Amano, Toyoaki Murohara
BACKGROUND: An inverse association between obesity, as defined by body mass index (BMI) and prognosis has been reported in patients with cardiovascular disease ("obesity paradox"). The aim of this study was to investigate whether adding nutritional information to BMI provides better risk assessment in patients undergoing elective percutaneous coronary intervention (PCI). METHOD: This study comprised 1004 patients undergoing elective PCI. We calculated each patient's controlling nutritional status (CONUT) score for nutritional screening at baseline...
January 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28070882/effect-of-a-180-mg-ticagrelor-loading-dose-on-myocardial-necrosis-in-patients-undergoing-elective-percutaneous-coronary-intervention-a-preliminary-study
#5
QuanFu Xu, YingGang Sun, Yi Zhang, Bo Liu, Lu Fang, ChengXing Shen, YiGang Li, Shu Meng
BACKGROUND: To examine whether a loading dose of ticagrelor on top of clopidogrel reduced post-percutaneous coronary intervention (PCI) myonecrosis. METHODS: Seventy seven coronary artery disease patients received a loading dose of 300 mg clopidogrel pre-PCI and were divided into three groups: group TT (n = 36): a loading dose of 180 mg ticagrelor pre-PCI, followed by ticagrelor 90 mg twice daily commencing one day post-PCI; group CT (n = 26): a maintenance dose of ticagrelor 90 mg twice daily; group CC (n = 15): clopidogrel 75 mg daily post-PCI...
January 10, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28068529/impact-of-high-dose-statins-on-vitamin-d-levels-and-platelet-function-in-patients-with-coronary-artery-disease
#6
Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Matteo Nardin, Alon Schaffer, Lucia Barbieri, Veronica Daffara, Paolo Marino, Giorgio Bellomo, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Statins represent a pivotal treatment in coronary artery disease, offering a reduction in cardiovascular risk even beyond their lipid-lowering action. However, the mechanism of these "pleiotropic" benefits of statins is poorly understood. Vitamin D has been suggested as a potential mediator of the anti-inflammatory, anti-thrombotic and vascular protecting effects of statins. Aim of present study was to assess the impact of a high-intensity statin therapy on vitamin D levels and platelet function in patients with coronary artery disease...
December 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28065791/the-neuroprotective-strategic-analysis-for-patients-with-acute-myocardial-infarction-combined-with-hypoxic-ischemic-encephalopathy-in-icu
#7
Yali Chao, Weiwei Hu, Xiaojuan Geng
BACKGROUND: We conducted this study to investigate the neuroprotective treatment strategies for patients with acute myocardial infarction (AMI) complicated with hypoxic ischemic encephalopathy (HIE) in the ICU. METHODS: A total of 83 cases that were diagnosed with secondary AMI for the first time were selected and divided into observation group (n=43) and the control group (n=40). All of patients underwent emergency or elective PCI. Patients in the control group were treated with mannitol to reduce intracranial pressure, cinepazide maleate to improve microcirculation in the brain and also given comprehensive treatments of oxygen inhalation, fluid infusion, acid-base imbalance correction, electrolyte disturbance, etc...
January 5, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28052754/the-burden-of-major-adverse-cardiac-events-in-patients-with-coronary-artery-disease
#8
I-Ting Tsai, Chao-Ping Wang, Yung-Chuan Lu, Wei-Chin Hung, Cheng-Ching Wu, Li-Fen Lu, Fu-Mei Chung, Chia-Chang Hsu, Yau-Jiunn Lee, Teng-Hung Yu
BACKGROUND: Patients with a history of cardiovascular disease are at high risk of developing secondary major adverse cardiac events (MACE). This study aimed to identify independent predictors of MACE after hospital admission which could be used to identify of high-risk patients who may benefit from preventive strategies. METHODS: This study included 1,520 consecutive patients with coronary artery disease (CAD) (654 with acute coronary syndrome (ACS) and 866 with elective percutaneous coronary intervention (PCI) patients) who received PCI and/or stenting...
January 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28029209/mortality-after-percutaneous-coronary-revascularization-prior-cardiovascular-risk-factor-control-and-improved-outcomes-in-patients-with-diabetes-mellitus
#9
Awsan Noman, Karthik Balasubramaniam, M Hafez A Alhous, Kelvin Lee, Peter Jesudason, Muhammad Rashid, Mamas A Mamas, Azfar G Zaman
OBJECTIVES: To assess the mortality in patients with diabetes mellitus (DM) following percutaneous coronary intervention (PCI) according to their insulin requirement and PCI setting (elective, urgent, and emergency). BACKGROUND: DM is a major risk factor to develop coronary artery disease (CAD). It is unclear if meticulous glycemic control and aggressive risk factor management in patients with DM has improved outcomes following PCI. METHODS: Retrospective analysis of prospectively collected data on 9,224 patients treated with PCI at a regional tertiary center between 2008 and 2011...
December 28, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27995343/pre-procedural-renal-resistive-index-accurately-predicts-contrast-induced-acute-kidney-injury-in-patients-with-preserved-renal-function-submitted-to-coronary-angiography
#10
Maciej T Wybraniec, Maria Bożentowicz-Wikarek, Jerzy Chudek, Katarzyna Mizia-Stec
The study aimed to evaluate the clinical utility of ultrasonographic intra-renal blood flow parameters, together with the wide range of different risk factors, for the prediction of contrast-induced acute kidney injury (CI-AKI) in patients with preserved renal function, referred for coronary angiography or percutaneous coronary interventions (CA/PCI). This prospective study covered 95 consecutive patients (69.5% men; median age 65 years) subject to elective or urgent CA/PCI. Data regarding 128 peri-procedural variables were collected...
December 19, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27994599/possible-inhibitory-effect-of-erythropoiesis-stimulating-agents-at-the-predialysis-stage-on-early-phase-coronary-events-after-hemodialysis-initiation
#11
Masato Nishimura, Keitaro Watanabe, Yuki Kitamura, Takao Nagashima, Toshiko Tokoro, Toru Takatani, Nodoka Sato, Satoru Yamazaki, Tetsuya Hashimoto, Hiroyuki Kobayashi, Toshihiko Ono
BACKGROUND: We examined whether the use of erythropoiesis-stimulating agents (ESAs) to correct anemia at the predialysis stage could inhibit early-phase coronary events after hemodialysis initiation. METHODS: We enrolled 242 patients with chronic kidney disease who had received continued medical treatments and initiated maintenance hemodialysis from 1 September 2000 to 31 December 2014 at Toujinkai Hospital. Patients with a previous history of blood transfusion or any cardiovascular events or interventions were excluded...
November 2016: Cardiorenal Medicine
https://www.readbyqxmd.com/read/27931181/platelet-aggregation-and-risk-of-stent-thrombosis-or-bleeding-in-interventionally-treated-diabetic-patients-with-acute-coronary-syndrome
#12
K Kukula, M Klopotowski, P K Kunicki, J Jamiolkowski, A Debski, P Bekta, M Polanska-Skrzypczyk, Z Chmielak, A Witkowski
BACKGROUND: Platelet aggregation monitoring in diabetic patients treated with coronary interventions (PCI) for an acute coronary syndrome (ACS) is a promising way of optimizing treatment and outcomes in this high risk group. The aim of the study was to verify whether clopidogrel response measured by Multiplate analyzer (ADPtest) in diabetic ACS patients treated with PCI predicts the risk of stent thrombosis or cardiovascular mortality and bleeding. METHODS: Into this prospective, observational study 206 elective PCI patients were enrolled...
December 8, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27928127/regional-variation-in-the-use-of-percutaneous-coronary-intervention-in-japan
#13
Takahiro Inoue, Hiroyo Kuwabara, Kiyohide Fushimi
BACKGROUND: Regional variations in health-care delivery, processes and spending have been reported across the world. Differences in revascularization procedures have been observed in the USA and Canada, but little is known about regional variation in revascularization procedures in Japan.Methods and Results:Diagnostic procedure combination summary tables for 2013 issued by the Japanese government were used. The rates of percutaneous coronary intervention (PCI) per 100,000 population aged ≥40 years in each prefecture were summarized by angina and myocardial infarction (MI)...
December 7, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27922567/validity-of-the-european-society-of-cardiology-s-psychosocial-screening-interview-in-patients-with-coronary-heart-disease-the-thoresci-study
#14
Eveline van Montfort, Johan Denollet, Jos Widdershoven, Nina Kupper
AIM: To examine the validity of the European Society of Cardiology (ESC) psychosocial screening instrument. METHOD: 508 acute (67%) or elective (33%) percutaneous coronary intervention (PCI) patients (mean age=63 years, SD=10; 81% male) completed the ESC screening interview and established questionnaires for psychosocial risk markers, i.e., depression (PHQ-9), anxiety (GAD-7), Type D personality (DS14), hostility (CMHS-7), and marital/work stress (MMQ-6, ERI) during or close after hospital admission...
December 2, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27916048/-the-impact-of-red-blood-cell-distribution-width-on-outcome-of-elective-percutaneous-coronary-intervention-in-non-anemia-patients
#15
X M Liu, J Z Dong, X H Liu, J P Kang, T Y Luo, Y Guan, T Y Dai, Y Zhang, R Bai, X Du, C S Ma
Objective: Previous studies have revealed that the red blood cell distribution width (RDW) was associated with long-term prognosis in patients undergoing percutaneous coronary intervention (PCI). However, they did not exclude patients with anemia. This study, thus, investigated the association between RDW and prognosis in non-anemia patients. Methods: A total of 2 732 patients underwent elective PCI from July 2009 to September 2011 were enrolled in the study. These patients were divided into two groups based on their baseline median RDW levels: low RDW group (RDW<12...
December 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/27912733/the-effect-of-percutaneous-coronary-intervention-on-habitual-physical-activity-in-older-patients
#16
Sarah J Charman, Vincent T van Hees, Louise Quinn, Joseph R Dunford, Bilal Bawamia, Murugapathy Veerasamy, Michael I Trenell, Djordje G Jakovljevic, Vijay Kunadian
BACKGROUND: Given the ongoing burden of cardiovascular disease and an ageing population, physical activity in patients with coronary artery disease needs to be emphasized. This study assessed whether sedentary behaviour and physical activity levels differed among older patients (≥75 years) following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) consisting of ST-segment elevation myocardial infarction (STEMI) and non STEMI (NSTEMI) versus an elective admission control group of stable angina patients...
December 3, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27902833/evaluation-of-ischemic-and-bleeding-risks-associated-with-2-parenteral-antiplatelet-strategies-comparing-cangrelor-with-glycoprotein-iib-iiia-inhibitors-an-exploratory-analysis-from-the-champion-trials
#17
Muthiah Vaduganathan, Robert A Harrington, Gregg W Stone, Efthymios N Deliargyris, Ph Gabriel Steg, C Michael Gibson, Christian W Hamm, Matthew J Price, Alberto Menozzi, Jayne Prats, Steven Elkin, Kenneth W Mahaffey, Harvey D White, Deepak L Bhatt
Importance: In the context of contemporary pharmacotherapy, optimal antiplatelet management with percutaneous coronary intervention (PCI) has not been well established. Objective: To compare the ischemic and bleeding risks associated with glycoprotein IIb/IIIa inhibitors (GPIs) and a potent P2Y12 antagonist, cangrelor, in patients undergoing PCI. Design, Setting, and Participants: An exploratory analysis of pooled patient-level data from the 3 phase 3 Cangrelor vs Standard Therapy to Achieve Optimal Management of Platelet Inhibition (CHAMPION PCI, CHAMPION PLATFORM, and CHAMPION PHOENIX) trials of patients undergoing elective or nonelective PCI...
November 30, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27899365/prevalence-and-clinical-significance-of-discordant-changes-in-fractional-and-coronary-flow-reserve-after-elective-percutaneous-coronary-intervention
#18
Junji Matsuda, Tadashi Murai, Yoshihisa Kanaji, Eisuke Usui, Makoto Araki, Takayuki Niida, Sadamitsu Ichijyo, Rikuta Hamaya, Tetsumin Lee, Taishi Yonetsu, Mitsuaki Isobe, Tsunekazu Kakuta
BACKGROUND: Fractional flow reserve (FFR) and coronary flow reserve (CFR) are well-validated physiological indices; however, changes in FFR and CFR after percutaneous coronary intervention (PCI) remain elusive. We sought to evaluate these changes and to investigate whether physiological indices predict cardiac event-free survival after PCI. METHODS AND RESULTS: Physiological assessment of 220 stenoses from 220 patients was performed before and after PCI. The changes in FFR and CFR were studied, and factors associated with CFR change were investigated...
November 29, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27893054/outcomes-and-temporal-trends-of-inpatient-percutaneous-coronary-intervention-at-centers-with-and-without-on-site-cardiac-surgery-in-the-united-states
#19
Kashish Goel, Tanush Gupta, Dhaval Kolte, Sahil Khera, Gregg C Fonarow, Deepak L Bhatt, Mandeep Singh, Charanjit S Rihal
Importance: There are concerns whether percutaneous coronary intervention (PCI) at centers without on-site cardiac surgery is safe outside of a tightly regulated research environment. Objective: To analyze the outcomes and temporal trends of inpatient PCI at centers without on-site cardiac surgery in an unselected and nationally representative population of the United States. Design, Setting, and Participants: A national inpatient sample (N = 6 912 232) was used to identify patients who underwent inpatient PCI in the United States from January 1, 2003, to December 31, 2012...
January 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27886817/antithrombotic-therapy-to-reduce-ischemic-events-in-acute-coronary-syndromes-patients-undergoing-percutaneous-coronary-intervention
#20
REVIEW
Freek W A Verheugt
Antithrombotic therapy is essential in the prevention of periprocedural death and myocardial infarction during and after percutaneous coronary intervention. In the pathogenesis of acute coronary syndromes (ACS), both platelets and the coagulation cascade play an important role. Therefore, periprocedural antithrombotic therapy is even more important in ACS than in elective PCI. The most used agents are aspirin, platelet P2Y12 blockers, platelet glycoprotein IIb/IIIa blockers, and parenteral anticoagulants. The P2Y12 blockers must be continued at least 12 months...
January 2017: Interventional cardiology clinics
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