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https://www.readbyqxmd.com/read/29786640/vitamin-d-in-vascular-calcification-a-double-edged-sword
#1
REVIEW
Jeffrey Wang, Jimmy J Zhou, Graham R Robertson, Vincent W Lee
Vascular calcification (VC) as a manifestation of perturbed mineral balance, is associated with aging, diabetes and kidney dysfunction, as well as poorer patient outcomes. Due to the current limited understanding of the pathophysiology of vascular calcification, the development of effective preventative and therapeutic strategies remains a significant clinical challenge. Recent evidence suggests that traditional risk factors for cardiovascular disease, such as left ventricular hypertrophy and dyslipidaemia, fail to account for clinical observations of vascular calcification...
May 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29786183/-hyperkalemia-as-a-limiting-factor-in-the-use-of-drugs-that-block-the-renin-angiotensin-aldosterone-system-raas
#2
Antonio Santoro, Marcora Mandreoli
Angiotensin-converting enzyme (ACE-I) inhibitors and ARBs have shown real efficacy in reducing blood pressure, proteinuria, in slowing the progression of chronic kidney disease (MRC) and in clinical improvement. in patients with heart failure, diabetes mellitus and ischemic heart disease. However, their use is limited by some side effects such as the increase in serum potassium (K), which can be particularly severe in patients with renal insufficiency. In the 23,000 patients followed by the PIRP project of the Emilia-Romagna Region, hyperkalaemia at the first visit (K> 5...
May 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29786051/urinary-extracellular-vesicle-a-potential-source-of-early-diagnostic-and-therapeutic-biomarker-in-diabetic-kidney-disease
#3
REVIEW
Wei-Cheng Xu, Ge Qian, Ai-Qun Liu, Yong-Qiang Li, He-Qun Zou
Objective: Diabetic kidney disease (DKD) has become one of the major causes of end-stage renal disease. Urinary extracellular vesicles (uEVs) contain rich biological information which could be the ideal source for noninvasive biomarkers of DKD. This review discussed the potential early diagnostic and therapeutic values of proteins and microRNAs in uEVs in DKD. Data Sources: This review was based articles published in PubMed, Embase, Cochrane, and Google Scholar databases up to November 20, 2017, with the following keywords: "Diabetic kidney disease", "Extracellular vesicle", and "Urine"...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785660/prevalence-of-hypertension-and-diabetes-after-exposure-to-extracorporeal-shock-wave-lithotripsy-in-patients-with-renal-calculi-a-retrospective-non-randomized-data-analysis
#4
Christian Daniel Fankhauser, Nilufar Mohebbi, Josias Grogg, Alexander Holenstein, Qing Zhong, Thomas Hermanns, Tullio Sulser, Johann Steurer, Poyet Cedric
PURPOSE: To evaluate the association of shock-wave lithotripsy (SWL) for kidney stones and hypertension or diabetes. METHODS: Patients with urolithiasis treated by SWL were retrospectively identified. To assess whether shock-wave application to the kidney is associated with long-term adverse effects, patients after SWL for kidney stones were selected as the main group of interest. Patients treated with shock waves for distal ureter stones only were chosen as a comparison group...
May 21, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29785400/previous-exercise-training-reduces-markers-of-renal-oxidative-stress-and-inflammation-in-streptozotocin-induced-diabetic-female-rats
#5
Liliany Souza de Brito Amaral, Cláudia Silva Souza, Rildo Aparecido Volpini, Maria Heloisa Massola Shimizu, Ana Carolina de Bragança, Daniele Canale, Antonio Carlos Seguro, Terezila Machado Coimbra, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares
The aim of this study is to evaluate the effects of regular moderate exercise training initiated previously or after induction of diabetes mellitus on renal oxidative stress and inflammation in STZ-induced diabetic female rats. For this purpose, Wistar rats were divided into five groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD), trained diabetic (TD), and previously trained diabetic (PTD). Only the PTD group was submitted to treadmill running for 4 weeks previously to DM induction with streptozotocin (40 mg/kg, i...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29785274/cross-sectional-assessment-of-achievement-of-therapeutic-goals-in-a-canadian-multidisciplinary-clinic-for-patients-with-advanced-chronic-kidney-disease
#6
Félix Rinfret, France Lambert, Joseph Tchetagni Youmbissi, Jean-François Arcand, Richard Turcot, Maral Alimardani Bessette, Solange Bourque, Vincent Moreau, Karine Tousignant, Diane Deschênes, Lyne Cloutier
Background: The implementation of advanced chronic kidney disease (CKD) multidisciplinary clinics has now demonstrated their effectiveness in delaying and even avoiding dialysis for patients with CKD. However, very little has been documented on the management and achievement of targets for a number of parameters in this context. Objective: Our goal was to assess our multidisciplinary clinic therapy performance in relation to the targets for hypertension, anemia, and calcium phosphate assessment...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29784631/safety-and-efficacy-of-polymer-free-biolimus-eluting-stents-in-all-comer-patients-the-rudi-free-study
#7
Gennaro Sardella, Giulio G Stefanini, Carlo Briguori, Corrado Tamburino, Franco Fabbiocchi, Francesco Rotolo, Fabrizio Tomai, Anita Paggi, Mario Lombardi, Gaetano Gioffrè, Rocco Sclafani, Andrea Rolandi, Alessandro Sciahbasi, Francesco Scardaci, Nicola Signore, Simone Calcagno, Massimo Mancone, Mauro Chiarito, Arturo Giordano
AIMS: Polymer-free biolimus-eluting stents (PF-BES) have been shown superior to bare metal stents in high bleeding risk (HBR) patients treated with 1-month dual antiplatelet therapy (DAPT). However, limited evidence is available on PF-BES in non-HBR patients. We aim to evaluate the safety and efficacy of PF-BES in all-comer patients undergoing percutaneous coronary interventions (PCI). METHODS AND RESULTS: Patients with stable coronary artery disease or acute coronary syndromes (ACS) undergoing PCI with PF-BES in routine clinical practice were included in a multicenter, prospective registry...
May 21, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29784612/risk-of-progression-of-nonalbuminuric-ckd-to-end-stage-kidney-disease-in-people-with-diabetes-the-cric-chronic-renal-insufficiency-cohort-study
#8
Digsu N Koye, Dianna J Magliano, Christopher M Reid, Christopher Jepson, Harold I Feldman, William H Herman, Jonathan E Shaw
BACKGROUND: Reduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the frequency with which it progresses to end-stage kidney disease (ESKD) is unknown. STUDY DESIGN: Multicenter prospective cohort study. SETTING & PARTICIPANTS: We included 1,908 participants with diabetes and reduced GFR enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study in the United States...
May 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29784023/delayed-presentation-of-severe-rhabdomyolysis-leading-to-acute-kidney-injury-following-atorvastatin-gemfibrozil-combination-therapy-a-case-report
#9
Chamara Dalugama, Manoji Pathirage, S A M Kularatne
BACKGROUND: Rhabdomyolysis is a rare but serious complication of lipid-lowering therapy. Statin and fibrate combination increases the risk of rhabdomyolysis possibly by pharmacodynamic interactions. Advanced age, diabetes, hypothyroidism, polypharmacy, and renal impairment are known to increase the risk of rhabdomyolysis. Management strategies include fluid resuscitation and urine alkalinization. Renal indications such as refractory hyperkalemia, acidosis, fluid overload, or uremic complications mandate renal replacement therapy in rhabdomyolysis...
May 22, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29783931/short-term-sequelae-of-preeclampsia-a-single-center-cohort-study
#10
Michael Girsberger, Catherine Muff, Irene Hösli, Michael Jan Dickenmann
BACKGROUND: Data on the prevalence of persistent symptoms in the first year after preeclampsia are limited. Furthermore, possible risk factors for these sequelae are poorly defined. We investigated kidney function, blood pressure, proteinuria and urine sediment in women with preeclampsia 6 months after delivery with secondary analysis for possible associated clinical characteristics. METHODS: From January 2007 to July 2014 all women with preeclampsia and 6-months follow up at the University Hospital Basel were analyzed...
May 21, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29783224/influence-of-risk-factors-on-insulin-resistance-in-patients-with-overweight-and-obesity
#11
Tetiana Maksymets, Natalia Karpyshyn, Taras Gutor, Helen Sklyarova, Eugen Sklyarov
OBJECTIVE: Introduction: Obesity is a multifactorial, heterogenic disease, associated with an increased risk of morbidity and mortality due to cardiovascular diseases, diabetes, cancer, chronic liver and kidney diseases. Excessive body weight and obesity are serious medical and social problems, since their incidence is constantly increasing and has reached global epidemic proportions. The aim: Determining the influence of risk factors on insulin resistance level in patients with overweight and obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782660/the-feared-five-fungal-infections-in-kidney-transplant-recipients-a-single-center20-year-experience
#12
Sandesh Parajuli, Alexandra Wick, Sameer Pandeya, Brad C Astor, Jeannina Smith, Arjang Djamali, Didier A Mandelbrot
Invasive fungal infections are a feared complication in kidney transplant recipients (KTRs). Here we present the University of Wisconsin experience with five invasive fungal infections - aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, and coccidioidomycosis - in KTRs transplanted between 01/01/1994 and 06/30/2014. During this period there were 128 cases of fungal infections; aspergillosis was the most common (72), followed by cryptococcosis (29), histoplasmosis (14), blastomycosis (10) and coccidioidomycosis (3)...
May 21, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29782632/prevalence-of-clinically-validated-primary-causes-of-end-stage-renal-disease-esrd-in-a-state-capital-in-northeastern-brazil
#13
Luana Rodrigues Sarmento, Paula Frassinetti Castelo Branco Camurça Fernandes, Marcelo Ximenes Pontes, Daniel Barros Santos Correia, Victhor Castelo Branco Chaves, Cecília Ferreira de Araújo Carvalho, Tiago Lima Arnaud, Matheus Henrique Seixas Dos Santos, Livia Cristina Barros Barreto, Larissa Alves Alexandre Moliterno
INTRODUCTION: Knowledge of validated primary causes of end-stage renal disease (ESRD) is extremely relevant in the realm of public health. The literature lacks validated studies on the primary causes of ESRD. OBJECTIVE: The aim of this study was to estimate the prevalence of the causes of ESRD in a State Capital in Northeastern Brazil. METHODS: This cross-sectional study was based on the analysis of medical records of patients on hemodialysis at five specialized centers in Fortaleza, CE, Brazil...
May 17, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29782631/reflections-on-end-of-life-dialysis
#14
Manuel Carlos Martins Castro
The world population is aging and diseases such as diabetes mellitus and systemic arterial hypertension are increasing the risk of patients developing chronic kidney disease, leading to an increase in the prevalence of patients on dialysis. The expansion of health services has made it possible to offer dialysis treatment to an increasing number of patients. At the same time, dialysis survival has increased considerably in the last two decades. Thus, patients on dialysis are becoming more numerous, older and with greater number of comorbidities...
May 17, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29782263/-nonvalvular-atrial-fibrillation-and-diabetic-nephropathy-epidemiology-prognosis-and-choice-of-anticoagulant-therapy
#15
N A Koziolova, E A Polyanskaya, M V Surovtseva, P G Karavaev
In this review we present data on prevalence of atrial fibrillation (AF) among patients with type 2 diabetes (T2D), diabetic nephropathy and chronic kidney disease (CKD). Patients with nonvalvular AF and T2D combined with CKD have elevated risk of both bleeding and thromboembolic complications, as well as of all cause death. Efficacy and safety of novel oral anticoagulants (NOAC) depend on comorbidities and can be determined by the presence of T2D and/or diabetic nephropathy. Use of warfarin in CKD in some cases provides no preventive effect relative to risk of stroke and is characterized by increased risk of bleeding because of poor INR control, and possibly development of calcification of arteries...
April 2018: Kardiologiia
https://www.readbyqxmd.com/read/29782054/assessment-of-porcine-endogenous-retrovirus-transmission-across-an-alginate-barrier-used-for-the-encapsulation-of-porcine-islets
#16
Claire Crossan, Nizar I Mourad, Karen Smith, Pierre Gianello, Linda Scobie
BACKGROUND: Subcutaneous implantation of a macroencapsulated patch containing human allogenic islets has been successfully used to alleviate type 1 diabetes mellitus (T1DM) in a human recipient without the need for immunosuppression. The use of encapsulated porcine islets to treat T1DM has also been reported. Although no evidence of pathogen transfer using this technology has been reported to date, we deemed it appropriate to determine if the encapsulation technology would prevent the release of virus, in particular, the porcine endogenous retrovirus (PERV)...
May 21, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29782007/intraportal-transplantation-of-pancreatic-islets-in-mouse-model
#17
Rahul Khatri, Birte Hussmann, Divya Rawat, Ali Osman Gürol, Thomas Linn
Pancreatic islet transplantation to reduce hyperglycemia is highly successful in rodents with chemically-induced diabetes. The most common transplantation site in experimental islet transplantation is the kidney capsule. However, as less is known about the interaction of pancreatic islets with blood constituents, it also makes sense to utilize the portal vein approach in experimental islet transplantation. This protocol demonstrates an intraportal islet transplantation technique in NMRI nude mice. Streptozotocin (180 mg/kg) is injected intraperitoneally to induce hyperglycemia in recipient mice...
May 5, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781952/optimizing-temperature-and-oxygen-supports-long-term-culture-of-human-islets
#18
Hirotake Komatsu, Jeffrey Rawson, Leonard Medrano, Colin A Cook, Alyssa Barriga, Nelson Gonzalez, Mayra Salgado, Keiko Omori, Fouad Kandeel, Yu-Chong Tai, Yoko Mullen
BACKGROUND: Islet transplantation is a promising treatment for type-1 diabetes; however, donor shortage is a concern. Even when a pancreas is available, low islet yield limits the success of transplantation. Islet culture enables pooling of multiple low-yield isolations into an effective islet mass, but isolated islets rapidly deteriorate under conventional culture conditions. Oxygen depletion in the islet core, which leads to central necrosis and volume loss, is one of the major reasons for this deterioration...
May 16, 2018: Transplantation
https://www.readbyqxmd.com/read/29781752/streptozotocin-induced-diabetes-in-rats-effects-of-white-butterfly-clerodendrum-volubile-leaves-on-blood-glucose-levels-lipid-profile-and-antioxidant-status
#19
Olorunfemi R Molehin, Omotade I Oloyede, Stephen A Adefegha
White Butterfly (Clerodendrum volubile) leaf is commonly used in traditional medicine for the management of various diseases including diabetes without the full understanding of the scientific basis for its use. This study sought to evaluate the antihyperglycemic, antihyperlipidemic and antioxidant effect of Clerodendrum volubile leaves in streptozotocin (STZ)-induced diabetic rats. Aqueous extract of C. volubile was prepared and its effect assessed on relevant enzymes associated with diabetes. Fifty Male Wistar rats were randomly separated into ten groups each containing five rats...
May 21, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29781558/characteristics-of-high-and-low-risk-individuals-in-the-priority-study-urinary-proteomics-and-mineralocorticoid-receptor-antagonism-for-prevention-of-diabetic-nephropathy-in-type-2-diabetes
#20
N Tofte, M Lindhardt, K Adamova, J Beige, J W J Beulens, A L Birkenfeld, G Currie, C Delles, I Dimos, L Francová, M Frimodt-Møller, P Girman, R Göke, T Havrdova, A Kooy, H Mischak, G Navis, G Nijpels, M Noutsou, A Ortiz, A Parvanova, F Persson, P L Ruggenenti, F Rutters, I Rychlík, G Spasovski, M Speeckaert, M Trillini, H von der Leyen, P Rossing
AIM: To compare clinical baseline data in individuals with Type 2 diabetes and normoalbuminuria, who are at high or low risk of diabetic kidney disease based on the urinary proteomics classifier CKD273. METHODS: We conducted a prospective, randomized, double-blind, placebo-controlled international multicentre clinical trial and observational study in participants with Type 2 diabetes and normoalbuminuria, stratified into high- or low-risk groups based on CKD273 score...
May 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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