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https://www.readbyqxmd.com/read/29149237/multimorbidity-among-persons-living-with-hiv-in-the-u-s
#1
Cherise Wong, Stephen J Gange, Richard D Moore, Amy C Justice, Kate Buchacz, Alison G Abraham, Peter F Rebeiro, John R Koethe, Jeffrey N Martin, Michael A Horberg, Cynthia M Boyd, Mari M Kitahata, Heidi M Crane, Kelly A Gebo, M John Gill, Michael J Silverberg, Frank J Palella, Pragna Patel, Hasina Samji, Jennifer Thorne, Charles S Rabkin, Angel Mayor, Keri N Althoff
Background: Age-associated conditions are increasingly common among persons living with HIV. A longitudinal investigation of their accrual is needed given their implications on clinical care complexity. We examined trends in the co-occurrence of age-associated conditions among persons living with HIV receiving clinical care, and differences in their prevalence by demographic subgroup. Methods: This cohort study was nested within the North American AIDS Cohort Collaboration on Research and Design...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29149222/personalized-medicine-and-hispanic-health-improving-health-outcomes-and-reducing-health-disparities-a-national-heart-lung-and-blood-institute-workshop-report
#2
M Larissa Avilés-Santa, John Heintzman, Nangel M Lindberg, Rafael Guerrero-Preston, Kenneth Ramos, Ana L Abraído-Lanza, Jonca Bull, Adolph Falcón, Mary Ann McBurnie, Ernest Moy, George Papanicolaou, Ileana L Piña, Jennifer Popovic, Shakira F Suglia, Miguel A Vázquez
Persons of Hispanic/Latino descent may represent different ancestries, ethnic and cultural groups and countries of birth. In the U.S., the Hispanic/Latino population is projected to constitute 29% of the population by 2060. A personalized approach focusing on individual variability in genetics, environment, lifestyle and socioeconomic determinants of health may advance the understanding of some of the major factors contributing to the health disparities experienced by Hispanics/Latinos and other groups in the U...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/29148546/-chronic-kidney-disease-the-relevant-information-for-an-occupational-physician
#3
REVIEW
Marcin Renke, Jacek Parszuto, Marcin Rybacki, Wojciech Wołyniec, Przemysław Rutkowski, Bolesław Rutkowski, Jolanta Walusiak-Skorupa, Alicja Dębska-Ślizień
For a number of years chronic kidney disease (CKD) has been listed in the group of lifestyle diseases, such as obesity, diabetes, cardiovascular disease and hypertension. It is estimated that in Poland more than 4 million people may suffer from various stages of CKD. Chronic kidney disease may also be a consequence of all the other civilization diseases. At the same time it is worth noting that nephrological problems are increasingly being taken into account in modern medical certification. The aim of this work is, among other things, to improve safe access to the labor for patients with kidney diseases...
November 8, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/29148006/autogenous-forearm-loop-arteriovenous-fistula-creation
#4
Weng Jun Tang, Arman Zaharil Mat Saad
INTRODUCTION: Arteriovenous fistula is a lifeline for end-stage kidney disease patients on dialysis. The quality of the vein and artery to be used plays a crucial role in attaining a functioning, reliable and long-lasting arteriovenous fistula. The aim of the study is to present an alternative for haemodialysis access to preserve the upper arm vasculature for future use - the forearm loop arteriovenous fistula. METHODS: From October 2015 to September 2016, 202 patients with chronic kidney disease (CKD), stages 4 and 5, underwent arteriovenous fistula creation at the Universiti Sains Malaysia Hospital, Malaysia...
November 13, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29147074/increased-levels-of-srage-in-diabetic-ckd-g5d-patients-a-potential-protective-mechanism-against-age-related-upregulation-of-fibroblast-growth-factor-23-and-inflammation
#5
Elena Dozio, Valentina Corradi, Elena Vianello, Elisa Scalzotto, Massimo de Cal, Massimiliano Marco Corsi Romanelli, Claudio Ronco
Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29146699/association-between-urine-ammonium-and-urine-tgf-%C3%AE-1-in-ckd
#6
Kalani L Raphael, Sarah Gilligan, Thomas H Hostetter, Tom Greene, Srinivasan Beddhu
BACKGROUND AND OBJECTIVES: Urinary ammonium excretion increases in response to nonvolatile acids to maintain normal systemic bicarbonate and pH. However, enhanced ammonia production promotes tubulointerstitial fibrosis in animal models. Therefore, a subset of individuals with CKD and normal bicarbonate may have acid-mediated kidney fibrosis that might be better linked with ammonium excretion than bicarbonate. We hypothesized that urine TGF-β1, as an indicator of kidney fibrosis, would be more tightly linked with urine ammonium excretion than serum bicarbonate and other acid-base indicators...
November 16, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29146600/n-glycan-profile-and-kidney-disease-in-type-1-diabetes
#7
Mairead L Bermingham, Marco Colombo, Stuart J McGurnaghan, Luke A K Blackbourn, Frano Vučković, Maja Pučić Baković, Irena Trbojević-Akmačić, Gordan Lauc, Felix Agakov, Anna S Agakova, Caroline Hayward, Lucija Klarić, Colin N A Palmer, John R Petrie, John Chalmers, Andrew Collier, Fiona Green, Robert S Lindsay, Sandra Macrury, John A McKnight, Alan W Patrick, Sandeep Thekkepat, Olga Gornik, Paul M McKeigue, Helen M Colhoun
OBJECTIVE: Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic kidney disease (DKD). We investigated associations between N-glycans and glycemic control and renal function in type 1 diabetes. RESEARCH DESIGN AND METHODS: Using serum samples from 818 adults who were considered to have extreme annual loss in estimated glomerular filtration rate (eGFR; i.e., slope) based on retrospective clinical records, from among 6,127 adults in the Scottish Diabetes Research Network Type 1 Bioresource Study, we measured total and IgG-specific N-glycan profiles...
November 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29146035/renal-outcomes-with-dipeptidyl-peptidase-4-inhibitors
#8
REVIEW
A J Scheen, P Delanaye
Dipeptidyl peptidase-4 inhibitors (DPP-4is) are increasingly being used in the management of type 2 diabetes (T2D). The present review summarizes the current knowledge of the effects of DPP-4is on renal outcomes by analyzing the experimental preclinical data, the effects of DPP-4is on urinary albumin-creatinine ratios (UACRs) and estimated glomerular filtration rates (eGFRs) from observational studies and clinical trials, and renal events (including kidney failure requiring renal replacement therapy) in recent large prospective cardiovascular outcome trials...
November 13, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29145743/novel-avenues-for-drug-discovery-in-diabetic-kidney-disease
#9
Matthew D Breyer, Matthias Kretzler
Diabetic kidney disease (DKD) has emerged as major cause of morbidity and mortality. After progressing to renal failure, over 70% of DKD patients are dead with five years. New treatments to slow this progression are desperately needed. Areas covered: This review highlights the current treatment options for people with DKD with a particular focus on angiotensin pathway blockade and the potential use of sodium glucose linked transporter 2 (SGLT2) inhibitors. These treatments are associated with an initial decrease in glomerular filtration rate (GFR) and albuminuria; there is also attention on renal hyperfiltration as therapeutic target...
November 16, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29145714/clinical-and-biochemical-correlates-of-male-hypogonadism-in-type-2-diabetes
#10
A Herrero, M Marcos, P Galindo, J M Miralles, J J Corrales
The origin of hypogonadism, a condition including both symptoms and biochemical criteria of androgen deficiency, in type 2 diabetes is poorly known. In a cross-sectional study of 267 unselected patients, we analyzed the potential correlation of several clinical and biochemical variables as well as chronic micro- and macrovascular diabetic complications with hypogonadism. Hypogonadism was present in 46 patients (17.2%) using a cutoff of total testosterone 10.4 nmol/L and in 31 (11.6%) with a cutoff of 8 nmol/L...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29142980/effectiveness-of-multifaceted-care-approach-on-adverse-clinical-outcomes-in-nondiabetic-ckd-a-systematic-review-and-meta-analysis
#11
Aminu K Bello, Bilal Qarni, Arian Samimi, Julius Okel, Trish Chatterley, Ikechi G Okpechi, Ben Vandermeer, Branko Braam
Introduction: The risk of major adverse events associated with chronic kidney disease (CKD) could potentially be reduced with effective medical interventions. The impact of multifaceted interventions as compared with usual care in patients with nondiabetic CKD is unclear. We performed a systematic review to analyze the impact of multifaceted interventions on reducing the risk of major adverse events in this population. Methods: Systematic review and meta-analysis...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29142978/severe-adverse-effects-associated-with-corticosteroid-treatment-in-patients-with-iga-nephropathy
#12
Qingqing Cai, Xinfang Xie, Jinwei Wang, Sufang Shi, Lijun Liu, Yuqing Chen, Jicheng Lv, Hong Zhang
Introduction: Few data are available on the risk of SAEs in corticosteroid users in IgAN populations. We describe the prevalence and risk factors of corticosteroid-related SAEs in a Chinese cohort. Methods: A total of 1034 IgAN patients were followed up in our renal center from 2003 to 2014. Prevalence of corticosteroid use and corticosteroid-related SAEs were noted. Logistic regression was used to search for risk factors of SAEs in corticosteroid users. Results: Of the 369 patients with steroids therapy, 46 patients (12...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29142975/sclerostin%C3%A2-a-debutant-on-the-autosomal-dominant-polycystic-kidney-disease-scene
#13
Magdalena Jankowska, Mathias Haarhaus, Abdul Rashid Qureshi, Bengt Lindholm, Pieter Evenepoel, Peter Stenvinkel
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease originating from a mutation in genes encoding polycystin 1 and 2. Recent evidence suggests that these polycystins mediate mechanosensation not only in the primary cilium of kidney cells but also in bone cells. The Wnt/β-catenin signaling pathway plays a central role in mechanotransduction in osteocytes. Mechanical unloading causes the upregulation of the Wnt inhibitor sclerostin. We tested the hypothesis that ADPKD associates with higher circulating sclerostin levels...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142974/profiling-of-plasma-metabolites-suggests-altered-mitochondrial-fuel-usage-and-remodeling-of-sphingolipid-metabolism-in-individuals-with-type%C3%A2-2-diabetes-and-kidney-disease
#14
Jian-Jun Liu, Sujoy Ghosh, Jean-Paul Kovalik, Jianhong Ching, Hyung Won Choi, Subramaniam Tavintharan, Choon Nam Ong, Chee Fang Sum, Scott A Summers, E Shyong Tai, Su Chi Lim
Introduction: Pathophysiology of diabetic kidney disease (DKD) is incompletely understood. We aim to elucidate metabolic abnormalities associated with DKD in type 2 diabetes mellitus (T2DM) by targeted plasma metabolomics. Methods: A total of 126 T2DM participants with early DKD (urinary albumin-to-creatinine ratio [ACR] 30-299 mg/g and eGFR ≥ 60 ml/min/1.73 m(2)), 154 overt DKD (ACR ≥ 300 mg/g or eGFR < 60 ml/min/1.73 m(2)), and 129 non-DKD T2DM controls (ACR < 30 mg/g and eGFR ≥ 60 ml/min/1...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142957/identifying-factors-that-influence-physicians-recommendations-for-dialysis-and-conservative-management-in-indonesia
#15
Eric A Finkelstein, Semra Ozdemir, Chetna Malhotra, Tazeen H Jafar, Hui Lin Choong, Johnny Suhardjono
Introduction: For elderly end-stage renal disease (ESRD) patients with multiple comorbidities, dialysis may offer little survival benefit compared to conservative management (CM). Yet, many elderly ESRD patients undergo dialysis, partly due to physicians' recommendations regarding treatment choice. This study aims to elucidate the factors that influence these recommendations. Methods: We surveyed a convenience sample of physicians who attended the 9th Asian Forum of Chronic Kidney Disease Initiative conference...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29142952/serum-ngal-and-cystatin-c-comparison-with-urinary-albumin-to-creatinine-ratio-and-inflammatory-biomarkers-as-early-predictors-of-renal-dysfunction-in-patients-with-type-2-diabetes
#16
Marcelo R Bacci, Ethel Z Chehter, Ligia A Azzalis, Beatriz Costa de Aguiar Alves, Fernando L A Fonseca
Introduction: Diabetic nephropathy is associated with specific histological changes. Early detection of poor glomerular and tubular function can be achieved with biomarkers of diabetes. The aim of this study was to evaluate the accuracy of kidney dysfunction biomarkers in type 2 diabetes (T2D). Methods: Patients with T2D were grouped according to their glycated hemoglobin level. Patients' urine and blood samples were taken to measure cystatin C (CysC), neutrophil gelatinase-associated lipocalin, beta-trace protein levels, and the first morning void albumin-to-creatinine ratio...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29142938/epidemiological-transition-of-end-stage-kidney-disease-in-oman
#17
Faisal Al Ismaili, Issa Al Salmi, Yaqoub Al Maimani, Abdul Massiah Metry, Humood Al Marhoobi, Alan Hola, Ronald L Pisoni
Introduction: The number of persons receiving renal replacement therapy (RRT) is estimated at more than 2.5 million worldwide, and is growing by 8% annually. Registries in the developing world are not up to standards compared to the United States Renal Data System (USRDS). Herein we examine the causes, progression, and magnitude of end-stage kidney disease (ESKD) over 3 decades in Oman. Methods: We examined ESKD data from 1983 to 2013. Data from 1998 to 2013 were obtained through an Information Management System...
January 2017: KI Reports
https://www.readbyqxmd.com/read/29142937/geographic-variation-and-us-county-characteristics-associated-with-rapid-kidney-function-decline
#18
Benjamin Bowe, Yan Xie, Hong Xian, Min Lian, Ziyad Al-Aly
Introduction: Geographic variation in the prevalence of chronic kidney disease and incidence of end-stage renal disease has been previously reported. However, the geographic epidemiology of rapid estimated glomerular filtration rate (eGFR) decline has not been examined. Methods: We built a longitudinal cohort of 2,107,570 US veterans to characterize the spatial epidemiology of and examine the associations between US county characteristics and rapid eGFR decline...
January 2017: KI Reports
https://www.readbyqxmd.com/read/29142574/frequency-of-type-2-diabetes-mellitus-in-nephropathic-patients-and-comparison-of-mean-magnesium-levels-in-nephropathic-patients-with-and-without-type-2-diabetes-mellitus
#19
Mariam Azeem, Adil Iqbal, Nasir Farooq Butt, Fawad Ahmad Randhawa, Uzma Malik
Objective: The objective of this study was to determine the frequency of Type 2 diabetes mellitus (T2DM) in patients with nephropathy (i.e. Chronic Kidney Disease Stage 1 to 3) and to compare the mean magnesium levels in diabetic nephropathic patients and non-diabetic nephropathic patients. Methods: This cross-sectional study was conducted in department of Medicine, Mayo Hospital Lahore from August 2014 to February 2015. Using non-probability purposive sampling 200 nephropathic (Chronic Kidney Disease Stage 1 to 3) patients were selected...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142432/inhibition-of-glycation-induced-cytotoxicity-protein-glycation-and-activity-of-proteolytic-enzymes-by-extract-from-perovskia-atriplicifolia-roots
#20
Mehran Miroliaei, Akram Aminjafari, Sylwester Ślusarczyk, Izabela Nawrot-Hadzik, Mehdi Rahimmalek, Adam Matkowski
Background: Protein glycation and glycotoxicity belong to the main oxidative-stress related complications in diabetes. Perovskia species are used in Asian folk medicine as antidiabetic herbs. Objective: The aim of this study was to verify the ability of the methanolic extract from Perovskia atriplicifolia Benth. roots to diminish glycation of albumin and to prevent cell damage in vitro. Furthermore, we tested the extract for in vitro antioxidant activity and inhibition of elastase and collagenase...
October 2017: Pharmacognosy Magazine
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