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https://www.readbyqxmd.com/read/28549320/light-emission-miracle-in-the-sea-and-preeminent-applications-of-bioluminescence-in-recent-new-biotechnology
#1
Sana Sharifian, Ahmad Homaei, Roohullah Hemmati, Khosro Khajeh
Bioluminescence is referred to the light emission by a living organism due to a specific biochemical reaction. This interesting feature of the organisms could highly influences behavioral and ecosystem dynamics. Luminescence, mostly observed in marine species, is generally higher in deep-living genera than in benthic or shallow organisms. However, among creatures living in land, fireflies, beetles, springtails and fungi have shown some bioluminescent activities. Classically, the emission of light is catalyzed by luciferase from a substrate...
May 17, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28549173/incidental-mosquitocidal-effect-of-an-ivermectin-mass-drug-administration-on-anopheles-farauti-conducted-for-scabies-control-in-the-solomon-islands
#2
Christian Kositz, Jeptah Talina, Jason Diau, Rowena Asugeni, Cheryl Whitehorn, David Mabey, Carlos Chaccour, Michael Marks
Background: The Solomon Islands is targeting elimination of malaria by 2030. The dominant vector is the predominantly exophagic, exophilic Anopheles farauti sensu strictu. This biting behaviour limits the efficacy of conventional vector control tools and highlights the need for new strategies. When administered to humans ivermectin has been shown to have a mosquitocidal effect. Mass drug administration (MDA) with ivermectin is an emerging strategy in the control of scabies. In this study we explored any incidental effect of ivermectin MDA conducted for scabies control on mosquitoes...
May 26, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28548972/assessment-of-adult-malnutrition-and-prognosis-with-bioelectrical-impedance-analysis-phase-angle-and-impedance-ratio
#3
Henry C Lukaski, Ursula G Kyle, Jens Kondrup
PURPOSE OF REVIEW: Malnutrition affects prognosis in many groups of patients. Although screening tools are available to identify adults at risk for poor nutritional status, a need exists to improve the assessment of malnutrition by identifying the loss of functional tissues that can lead to frailty, compromised physical function, and increased risk of morbidity and mortality, particularly among hospitalized and ill patients and older adults. Bioimpedance analysis (BIA) offers a practical approach to identify malnutrition and prognosis by assessing whole-body cell membrane quality and depicting fluid distribution for an individual...
May 25, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28548845/a-new-analytical-framework-for-verification-of-biomarkers-of-exposure-to-chemicals-combining-human-biomonitoring-and-water-fingerprinting
#4
Luigi Lopardo, Andrew Cummins, Axel Rydevik, Barbara Kasprzyk-Hordern
Molecular epidemiology approaches in human biomonitoring are powerful tools that allow for verification of public exposure to chemical substances. Unfortunately, due to logistical difficulties and high cost, they tend to evaluate small study groups and as a result might not provide comprehensive large scale community-wide exposure data. Urban water fingerprinting provides a timely alternative to traditional approaches. It can revolutionise the human exposure studies as urban water represents collective community-wide exposure...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28548827/dynamic-disorder-and-electronic-structures-of-electron-precise-dianionic-diboranes-insights-from-solid-state-multinuclear-magnetic-resonance-spectroscopy
#5
Y T Angel Wong, Johannes Landmann, Maik Finze, David L Bryce
The J(11B, 11B) coupling constants of various salts of the electron-precise hexacyanodiborane(6) dianion, [B2(CN)6]2-, were obtained using 11B double-quantum filtered (DQF) J-resolved solid-state nuclear magnetic resonance (SSNMR) spectroscopy. Our results show that the magnitude of the DQF J splitting is influenced by both the crystallo-graphic symmetry of the system and the presence of dynamics. The splittings are amplified by a factor of 3 as compared to the corresponding theoretical J coupling constants for cases where 1) there is an absence of dynamics but the boron pairs are crystallographically equivalent, or 2) the boron pairs are crystallographically inequivalent but are rendered magnetically equivalent on the timescale of the experiment due to dynamic disorder, which was identified by 11B and 13C SSNMR experiments...
May 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28548044/falcon-a-highly-flexible-open-source-software-for-closed-loop-neuroscience
#6
Davide Ciliberti, Fabian Kloosterman
OBJECTIVE: Closed-loop experiments provide unique insights into brain dynamics and function. Here, we demonstrate an open-source software platform that enables high-performance real-time processing of streaming experimental data, suitable for a wide range of closed-loop experiments. APPROACH: We wrote a C++ multi-threaded software (Falcon) in which the user can load and execute an arbitrary processing graph. Each node in the graph is internally mapped to a single thread and nodes communicate with each other through thread-safe buffers...
May 26, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28547935/malnutrition-risk-of-older-people-across-district-health-board-community-hospital-and-residential-care-settings-in-new-zealand
#7
Carol Wham, Emily Fraser, Julia Buhs-Catterall, Rebecca Watkin, Cheryl Gammon, Jacqui Allen
OBJECTIVE: To determine the prevalence of malnutrition risk in older people across three settings. METHODS: Older people living in the community or newly admitted to hospital or residential care were assessed for malnutrition risk using the validated Mini-Nutritional Assessment - Short Form and dysphagia risk using the Eating Assessment Tool-10. Demographic, physical and health data were collected. RESULTS: Of 167 participants, 23% were malnourished and 35% were at high risk of malnutrition...
May 25, 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/28547934/endo-laparoscopic-inguinal-hernia-repair-what-is-its-role
#8
REVIEW
Anil Sharma, Priyank Chelawat
Hernia repair techniques vary greatly depending upon the setting, surgeons, insurance reimbursement systems, resources, and logistical capabilities. Open mesh repair is the most frequently used technique. Choosing the best technique for inguinal hernia repair is a challenge. There is no single technique to manage every type of hernia. Today, laparoscopy and robotics are at the forefront of advanced surgical tools and offer a range of options for general surgeons who are critically evaluating new procedures...
May 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28547868/improving-three-dimensional-mechanical-imaging-of-breast-lesions-with-principal-component-analysis
#9
Mohit Tyagi, Yuqi Wang, Timothy Hall, Paul E Barbone, Assad A Oberai
PURPOSE: Elastography has emerged as a new tool for detecting and diagnosing many types of diseases including breast cancer. To date, most clinical applications of elastography have utilized two-dimensional strain images. The goal of this paper is to present a new quasi-static elastography technique that yields shear modulus images in three dimensions METHODS: An automated breast volume scanner was used to acquire ultrasound images of the breast as it was gently compressed. Cross-correlation between successive images was used to determine the displacement within the tissue...
May 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28547771/translation-of-wnt-developmental-programs-into-stem-cell-replacement-strategies-for-the-treatment-of-parkinson-s-disease
#10
REVIEW
Enrique M Toledo, Daniel Gyllborg, Ernest Arenas
Wnt signalling is a highly conserved pathway across species that is critical for normal development and is deregulated in multiple diseases including cancer and neurodegeneration. Wnt signalling is critically required for midbrain dopaminergic (mDA) neuron development and maintenance. Understanding the molecular processes controlled by Wnt signalling may thus hold the key to understand the physiopathology and to develop novel therapies aimed at preventing the loss of mDA neurons in Parkinson's disease (PD)...
May 26, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28547585/aio-casilio-a-robust-crispr-cas9-pumilio-system-for-chromosome-labeling
#11
Shuxian Zhang, Zhan Song
The biological function of chromatin bases on its spatial organization and dynamic activities in different situations. Labeling and tracing of genomic sequences has been a huge challenge in studying the spatial dynamics of chromatin. We reported the development of 'all-in-one Casilio system (Aio-Casilio)', a new system that enables the labeling of endogenous genomic loci. The Aio-Casilio system consists of the dCas9 protein, mClover fused with the Pumilio and FBF proteins RNA-binding domain (PUF domain) and an U6-sgRNA appended with multiple PUF-binding site(s)...
May 25, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28547247/a-new-tk-model-approach-to-assess-the-effect-of-migration-on-copper-toxicokinetics-in-inbred-populations-of-the-flour-beetle-tribolium-castaneum
#12
Sebastian Żmudzki, Natnael T Hamda, Patrycja Gibas-Tybur
The aim of the study was to determine the influence of migration on copper (Cu) kinetics of male Tribolium castaneum after 25 generations of exposure for Cu-adapted and non-Cu-adapted inbred lines. Adapted lines were kept on a flour medium contaminated with 1000 mg Cu kg(-1). A medium contaminated with 2000 mg Cu kg(-1) of copper was used during the intoxication phase. Based on our data and literature reports, we introduced a new two-phase four-stage toxicokinetics (TK) model. The intoxication phase was successfully divided into three stages with separate assimilation rate constant (ka) and elimination rate constant (ke) values...
May 26, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28547176/metabolic-volume-performs-better-than-suvmax-in-the-detection-of-left-ventricular-assist-device-driveline-infection
#13
Nemanja Avramovic, Angelo Maria Dell'Aquila, Matthias Weckesser, Danka Milankovic, Alexis Vrachimis, Jürgen R Sindermann, Christian Wenning
PURPOSE: A continuous-flow left ventricular assist device (LVAD) is a new and highly promising therapy in supporting end-stage heart failure patients, either bridging them to heart transplantation or as a destination therapy. Infection is one of the major complications associated with LVAD implants. (18)F-FDG PET/CT has already been shown to be useful in the detection of LVAD infection. The goal of this study was to compare the diagnostic accuracy of different PET analysis techniques (visual grading versus SUVmax and metabolic volume)...
May 25, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28547013/new-cfd-tools-to-evaluate-nasal-airflow
#14
M A Burgos, E Sanmiguel-Rojas, C Del Pino, M A Sevilla-García, F Esteban-Ortega
Computational fluid dynamics (CFD) is a mathematical tool to analyse airflow. As currently CFD is not a usual tool for rhinologists, a group of engineers in collaboration with experts in Rhinology have developed a very intuitive CFD software. The program MECOMLAND(®) only required snapshots from the patient's cross-sectional (tomographic) images, being the output those results originated by CFD, such as airflow distributions, velocity profiles, pressure, temperature, or wall shear stress. This is useful complementary information to cover diagnosis, prognosis, or follow-up of nasal pathologies based on quantitative magnitudes linked to airflow...
May 25, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28546971/the-impact-of-the-customer-relationship-management-on-organizational-productivity-customer-trust-and-satisfaction-by-using-the-structural-equation-model-a-study-in-the-iranian-hospitals
#15
Maryam Yaghoubi, Hamed Asgari, Marzieh Javadi
CONTEXT: One of the challenges in the fiercely competitive space of health organizations is responding to customers and building trust and satisfaction in them in the shortest time, with best quality and highest productivity. Hence the aim of this study is to survey the impact of customer relationship management (CRM) on organizational productivity, customer loyalty, satisfaction and trust in selected hospitals of Isfahan (in Iran). MATERIALS AND METHODS: This study is a correlation descriptive research...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28546735/nonparametric-regression-method-for-broad-sense-agreement
#16
Akm Fazlur Rahman, Limin Peng, Amita Manatunga, Ying Guo
Characterizing the correspondence between an ordinal measurement and a continuous measurement is often of interest in mental health studies. To this end, Peng, Li, Guo, and Manatunga (2011) introduced the concept of broad sense agreement (BSA) and developed nonparametric estimation and inference for a BSA measure. In this work, we propose a non-parametric regression framework for BSA, which provides a robust tool to further investigate population heterogeneity in BSA. We develop inferential procedures including regression function estimation and hypothesis testing...
2017: Journal of Nonparametric Statistics
https://www.readbyqxmd.com/read/28546435/a-simple-pipeline-for-mapping-point-mutations
#17
Guy Wachsman, Jennifer L Modliszewski, Manuel Valdes, Philip N Benfey
A forward genetic screen is one of the best methods for revealing the function of genes. In plants, this technique is highly efficient as it is relatively easy to grow and screen hundreds or thousands of individuals. The cost-efficiency and ease of data production afforded by next-generation sequencing has created new opportunities for rapid mapping of induced mutations. Current mapping tools are often not user-friendly, complicated, or require extensive preparation steps. To simplify the process of mapping new mutations, we developed a pipeline that takes next generation sequencing fastq files as input, calls on several well-established and freely available genome-analysis tools, and outputs the most likely causal DNA changes...
May 25, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28546386/assessment-of-gene-flow-between-gossypium-hirsutum-and-gossypium-herbaceum-evidence-of-unreduced-gametes-in-the-diploid-progenitor
#18
E Montes, O Coriton, F Eber, V Huteau, J M Lacape, C Reinhardt, D Marais, J L Hofs, A M Chèvre, C Pannetier
In the framework of a gene flow assessment, we investigated the natural hybridization rate between Gossypium hirsutum (AADD genome) and G. herbaceum (AA genome). The latter species, a diploid progenitor of G. hirsutum, is spontaneously present in South Africa. Reciprocal crosses were performed without emasculation between G. herbaceum and G. hirsutum Neither examination of the morphological characteristics nor flow cytometry analysis of the 335 plants resulting from the G. hirsutum x G. herbaceum cross showed any hybrid features...
May 25, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28546384/systematic-analysis-of-the-dna-damage-response-network-in-telomere-defective-budding-yeast
#19
Eva-Maria Holstein, Greg Ngo, Conor Lawless, Peter Banks, Matthew Greetham, Darren Wilkinson, David Lydall
Functional telomeres are critically important to eukaryotic genetic stability. Scores of proteins and pathways are known to affect telomere function. Here, we report a series of related genome-wide genetic interaction screens performed on budding yeast cells with acute or chronic telomere defects. Genetic interactions were examined in cells defective in Cdc13 and Stn1, affecting two components of CST, a single stranded DNA (ssDNA) binding complex that binds telomeric DNA. For comparison, genetic interactions were also examined in cells with defects in Rfa3, affecting the major ssDNA binding protein, RPA, which has overlapping functions with CST at telomeres...
May 25, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28546127/new-genes-for-accurate-normalization-of-qrt-pcr-results-in-study-of-ips-and-ips-derived-cells
#20
A S Artyukhov, E B Dashinimaev, V O Tsvetkov, A P Bolshakov, E V Konovalova, S N Kolbaev, E A Vorotelyak, A V Vasiliev
iPSC-derived cells (from induced pluripotent stem cells) are a useful source that provide a powerful and widely accepted tool for the study of various types of human cells in vitro. Indeed, iPSC-derived cells from patients with hereditary diseases have been shown to reproduce the hallmarks of these diseases in vitro, phenotypes that can then also be manipulated in vitro. Quantitative reverse transcription PCR (qRT-PCR) is often used to characterize the progress of iPSC differentiation, validate mature cell types and to determine levels of pathological markers...
May 22, 2017: Gene
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