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https://www.readbyqxmd.com/read/28927017/an-improved-evidential-iowa-sensor-data-fusion-approach-in-fault-diagnosis
#1
Yongchuan Tang, Deyun Zhou, Miaoyan Zhuang, Xueyi Fang, Chunhe Xie
As an important tool of information fusion, Dempster-Shafer evidence theory is widely applied in handling the uncertain information in fault diagnosis. However, an incorrect result may be obtained if the combined evidence is highly conflicting, which may leads to failure in locating the fault. To deal with the problem, an improved evidential-Induced Ordered Weighted Averaging (IOWA) sensor data fusion approach is proposed in the frame of Dempster-Shafer evidence theory. In the new method, the IOWA operator is used to determine the weight of different sensor data source, while determining the parameter of the IOWA, both the distance of evidence and the belief entropy are taken into consideration...
September 18, 2017: Sensors
https://www.readbyqxmd.com/read/28926709/simulating-osmotic-equilibria-a-new-tool-to-calculate-activity-coefficients-in-concentrated-aqueous-salt-solutions
#2
Michael Bley, Magali Duvail, Philippe Guilbaud, Jean-Francois Dufrêche
Herein, a new theoretical method simulating osmotic equilibria and activities is presented, where a bulk liquid and its corresponding vapor phase are simulated with molecular dynamics using polarizable force fields. Time-averaged number density profiles based on the resulting trajectories provide the amount of evaporated molecules present in the vapor phase and consequently the vapor phase density. The activity of the solvent and the corresponding osmotic coefficient are determined by the vapor density at a certain solute concentration with respect to the reference vapor density of the pure solvent...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28926412/endoscopic-ultrasound-and-related-technologies-for-the-diagnosis-and-treatment-of-pancreatic-disease-research-gaps-and-opportunities-summary-of-a-national-institute-of-diabetes-and-digestive-and-kidney-diseases-workshop
#3
Linda S Lee, Dana K Andersen, Reiko Ashida, William R Brugge, Mimi I Canto, Kenneth J Chang, Suresh T Chari, John DeWitt, Joo Ha Hwang, Mouen A Khashab, Kang Kim, Michael J Levy, Kevin McGrath, Walter G Park, Aatur Singhi, Tyler Stevens, Christopher C Thompson, Mark D Topazian, Michael B Wallace, Sachin Wani, Irving Waxman, Dhiraj Yadav, Vikesh K Singh
A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to address the research gaps and opportunities in pancreatic endoscopic ultrasound (EUS). The event occurred on July 26, 2017 in 4 sessions: (1) benign pancreatic diseases, (2) high-risk pancreatic diseases, (3) diagnostic and therapeutics, and (4) new technologies. The current state of knowledge was reviewed, with identification of numerous gaps in knowledge and research needs. Common themes included the need for large multicenter consortia of various pancreatic diseases to facilitate meaningful research of these entities; to standardize EUS features of different pancreatic disorders, the technique of sampling pancreatic lesions, and the performance of various therapeutic EUS procedures; and to identify high-risk disease early at the cellular level before macroscopic disease develops...
September 18, 2017: Pancreas
https://www.readbyqxmd.com/read/28926321/evaluation-of-platelet-activation-during-storage-in-leukocyte-depleted-platelet-concentrates
#4
Miodrag Vucic, Zoran Stanojkovic, Ana Antic, Jelana Vucic, Voja Pavlovic
Structural and functional changes in platelets during storage can lead to the loss of platelet reactivity and response. Our aim was to evaluate leukocyte-depleted platelet concentrates, obtained by in-line filtration on storage days 0, 3 and 5. In non-filtered platelet concentrates (NF-PC) group, 180 whole blood units were collected with quadruple blood bags and then compared to another group of 180 whole blood units (leukocyte-depleted platelet concentrates [LD-PC]), collected in Imuflex Whole Blood Filter Saving Platelets (WB-SP) bags with an integrated leukoreduction filter, with regard to the platelet quality and characteristics...
September 19, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28926155/idna-screening-disease-vectors-as-vertebrate-samplers
#5
Arthur Kocher, Benoit De Thoisy, François Catzeflis, Sophie Valiere, Anne-Laure Bañuls, Jérôme Murienne
In the current context of global change and human-induced biodiversity decline, there is an urgent need for developing sampling approaches able to accurately describe the state of biodiversity. Traditional surveys of vertebrate fauna involve time-consuming and skill-demanding field methods. Recently, the use of DNA derived from invertebrate parasites (leeches and blowflies) was suggested as a new tool for vertebrate diversity assessment. Blood meal analyses of arthropod disease vectors have long been performed to describe their feeding behaviour, for epidemiological purposes...
September 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28926145/a-crispr-reimagining-new-twists-and-turns-of-crispr-beyond-the-genome-engineering-revolution
#6
Robert J Plummer, Yi Guo, Ying Peng
Despite its explosive applications in genome engineering, CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) has been developed into a versatile tool beyond its well-known nuclease function. In this prospect article, we summarize a few exciting "off-label" applications of CRISPR including manipulating DNA sequences, visualizing chromosomal loci in living cells, and modulating transcription and chromatin structures. These novel applications will likely elevate CRISPR tools into yet another level of sophistication and diversity, leading to many more exciting cell biological discoveries...
September 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28926133/synthesis-of-thiophene-based-optical-ligands-that-selectively-detect-tau-pathology-in-alzheimer%C3%A2-s-disease
#7
Peter Nilsson, Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therese Klingstedt, Nigel Cairns
The accumulation of protein aggregates is associated with many devastating neurodegenerative diseases and the development of molecular ligands able to detect these pathological hallmarks is essential. Here, we report the synthesis of thiophene based optical ligands, denoted bi-thiophene-vinyl-benzothiazoles (bTVBTs) that can be utilized for selective assignment of tau aggregates in brain tissue with Alzheimer´s disease (AD) pathology. The ability of the ligands to selectively distinguish tau deposits from the other AD associated pathological hallmark, senile plaques consisting of aggregated amyloid-β (Aβ) peptide, were reduced when the chemical composition of the ligands were altered, verifying that specific molecular interactions between the ligands and the aggregates are necessary for the selective detection of tau deposits...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28926007/economics-for-assisting-policy-makers-to-take-decisions-about-new-and-endemic-diseases
#8
T E Carpenter
Animal health policy-makers are frequently faced with making decisions concerning the control and exclusion of diseases in livestock and wildlife populations. Economics is one of the tools they have to aid their decision-making. It can enable them to make objective decisions based on the expected costs and benefits of their policy. In addition, economics can help them determine both the distribution impact and the indirect impact of their decisions. However, economics is only one of many tools available to policy-makers, who also need to consider non-economic outcomes in their decision-making process...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925965/studying-the-structural-significance-of-galectin-design-by-playing-a-modular-puzzle-homodimer-generation-from-human-tandem-repeat-type-heterodimeric-galectin-8-by-domain-shuffling
#9
Anna-Kristin Ludwig, Malwina Michalak, Nadya Shilova, Sabine André, Herbert Kaltner, Nicolai V Bovin, Jürgen Kopitz, Hans-Joachim Gabius
Tissue lectins are emerging (patho)physiological effectors with broad significance. The capacity of adhesion/growth-regulatory galectins to form functional complexes with distinct cellular glycoconjugates is based on molecular selection of matching partners. Engineering of variants by changing the topological display of carbohydrate recognition domains (CRDs) provides tools to understand the inherent specificity of the functional pairing. We here illustrate its practical implementation in the case of human tandem-repeat-type galectin-8 (Gal-8)...
September 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28925890/the-use-of-hemodynamic-and-cerebral-monitoring-to-study-pharmacodynamics-in-neonates
#10
A Smits, L Thewissen, A Dereymaeker, E Dempsey, A Caicedo, Gunnar Naulaers
BACKGROUND: Drugs acting on the cardiovascular and central nervous system often display relatively fast clinical responses, which may differ in neonates compared to children and adults. Introduction of bedside monitoring tools might be of additional value in the pharmacodynamic (PD) assessment of such drugs in neonates. METHODS: We aim to provide an overview of the frequently used monitoring tools to assess drug effects on the hemodynamic status as well as the cerebral circulation, oxygenation and cerebral metabolism in neonates...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925862/biofactories-for-the-production-of-recombinant-phytases-and-its-application-in-animal-feed-industry
#11
Thais P P de Souza, Resyla M da Mariano, Mariana S Vieira, Suliana F V Andrade, Renato R Godoi, Ana Flavia A Gonçalves, Luciana P Naves, William J N Lima, Daniel B Gonçalves, Mariana Campos da Paz, Alexsandro S Galdino
BACKGROUND: Phytases are enzymes capable of degrading phytic acid and are used in animal feed supplementation in order to improve digestibility through the release of minerals such as phosphorus. Recent inventions show interest in production and optimization of recombinant phytases with biochemical and physicochemical characteristics promising for animal feed industry. METHODS: This review article is focused on relevant patents of the promising phytases, as well as the commonly used expression systems for its production, and also the tools currently used to generate new phytases...
September 15, 2017: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/28925498/electronic-diary-for-recording-headaches-triggers-and-medication-use-development-and-evaluation
#12
Siavash Bandarian-Balooch, Paul R Martin, Brenton McNally, Arissa Brunelli, Sharon Mackenzie
OBJECTIVE: To evaluate an e-diary developed for measuring headaches, triggers, and medication consumption, in terms of reliability and validity, and variables such as ease of use and participant compliance. BACKGROUND: For many decades, behavioral treatment of headaches has been evaluated via participants completing paper diaries recording their headaches and associated phenomena. There is some limited evidence supporting the reliability and validity of paper diaries, and criticisms have been offered such as the large amount of effort involved for both participants and researchers...
September 19, 2017: Headache
https://www.readbyqxmd.com/read/28925489/a-new-score-predicting-intraprocedural-risk-in-patients-undergoing-ct-guided-percutaneous-needle-pulmonary-biopsy-cath-score
#13
R Iezzi, A Larici, A Contegiacomo, M T Congedo, A Siciliani, A Infante, G Coppola, F Carchesio, S Margaritora, P Granone, R Manfredi, C Colosimo
OBJECTIVE: To develop a new score (CATH-score) for predicting intra-procedural risk in patients undergoing CT-guided percutaneous needle pulmonary biopsy. PATIENTS AND METHODS: 100 CT-guided lung biopsies performed with a 18 Gauge (G) needle (Pilot Group) were reviewed to analyse patient-, lesion- and procedure-related variables to identify risk factors for procedural complications (pneumothorax and parenchymal bleeding) and diagnosis failure. A scoring system for predicting complications and choosing the right needle (16 G, 18 G, 21 G) was developed using risk factors weighting and prospectively applied to 153 consecutive biopsies (CATH-score Group); complications and diagnostic rates obtained were compared with a group of patients (Control Group) that underwent lung biopsy; in this group of patients the choice of the calliper of the needle was based on the operator experience...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28925472/the-erlangen-questionnaire-a-new-5-item-screening-tool-for-obstructive-sleep-apnea-in-a-sleep-clinic-population-a-prospective-double-blinded-study
#14
M Traxdorf, K Tziridis, C Scherl, H Iro, J Haferkamp
OBJECTIVE: The aim of this study was to develop and validate a simplified screening tool for identifying obstructive sleep apnea (OSA) in a sleep clinic population. PATIENTS AND METHODS: A total of 160 patients from a sleep clinic population was enrolled in the prospective, double-blinded study. OSA was defined by using diagnostic criteria of the ICSD-3 after overnight polysomnography (n=96) or polygraphy (n=64). The first 60 patients filled out a multi-item questionnaire and formed the development group...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28925381/cavity-qed-with-hybrid-nanocircuits-from-atomic-like-physics-to-condensed-matter-phenomena
#15
Audrey Cottet, Matthieu C Dartiailh, Matthieu M Desjardins, Tino Cubaynes, Lauriane C Contamin, Matthieu Delbecq, Jérémie J Viennot, Laure E Bruhat, Benoit Douçot, Takis Kontos
Circuit QED techniques have been instrumental in manipulating and probing with exquisite sensitivity the quantum state of superconducting quantum bits coupled to microwave cavities. Recently, it has become possible to fabricate new devices in which the superconducting quantum bits are replaced by hybrid mesoscopic circuits combining nanoconductors and metallic reservoirs. This mesoscopic QED provides a new experimental playground to study the light-matter interaction in electronic circuits. Here, we present the experimental state of the art of mesoscopic QED and its theoretical description...
September 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28925375/modelling-the-effect-of-electrode-displacement-on-transcranial-direct-current-stimulation-tdcs
#16
Sriharsha Ramaraju, Mohammed Ali Roula, Peter McCarthy
Transcranial Direct Current Stimulation (tDCS) is a neuromodulatory technique that delivers a low-intensity, direct current to cortical areas with the purpose of modulating underlying brain activity. Recent studies have reported inconsistencies in tDCS outcomes. The underlying assumption of many tDCS studies has been that replication of electrode montage equates to replicating stimulation conditions. It is possible however that anatomical difference between subjects, as well as inherent inaccuracies in montage placement, could affect current flow to targeted areas...
September 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28925336/commentary-new-tools-on-the-horizon-to-assess-the-accuracy-of-aortic-stent-graft-deployment
#17
Frederico Bastos Gonçalves, Hence J M Verhagen
No abstract text is available yet for this article.
October 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28924695/charge-splitting-in-situ-recorder-csir-for-real-time-examination-of-plasma-charging-effect-in-finfet-beol-processes
#18
Yi-Pei Tsai, Ting-Huan Hsieh, Chrong Jung Lin, Ya-Chin King
A novel device for monitoring plasma-induced damage in the back-end-of-line (BEOL) process with charge splitting capability is first-time proposed and demonstrated. This novel charge splitting in situ recorder (CSIR) can independently trace the amount and polarity of plasma charging effects during the manufacturing process of advanced fin field-effect transistor (FinFET) circuits. Not only does it reveal the real-time and in situ plasma charging levels on the antennas, but it also separates positive and negative charging effect and provides two independent readings...
September 18, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28924673/super-resolution-high-content-screening-and-analysis
#19
K Soliman
Revealing the subcellular phenotypes at the molecular scale is critical to understand the mechanisms by which the cells function and respond to chemical treatments. Super-resolution microscopy and robust analysis tools enabled biologists to reveal and quantify phenotypes at unprecedented resolution. Developing automated imaging analysis solutions for super-resolution imaging will make high-content-screening (HCS) applicable for super-resolution microscopy, which will give access to new complex information. Here, I provide an instant automated analysis procedure for analyzing super-resolution images via CellProfiler ( www...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28924662/correlative-super-resolution-fluorescence-imaging-and-atomic-force-microscopy-for-the-characterization-of-biological-samples
#20
Patricia Bondia, Santiago Casado, Cristina Flors
Recent advances in imaging tools have greatly improved our ability to analyze the structure and molecular components of a wide range of biological systems at the nanoscale. High resolution imaging can be performed with a handful of techniques, each of them revealing particular features of the sample. A more comprehensive picture of a biological system can be achieved by combining the information provided by complementary imaging methods. Specifically, the correlation between super-resolution fluorescence imaging and atomic force microscopy (AFM) provides high resolution topography as well as specific chemical information, the latter with a spatial resolution that approaches that of AFM...
2017: Methods in Molecular Biology
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