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https://www.readbyqxmd.com/read/28288414/butyrate-induces-ros-mediated-apoptosis-by-modulating-mir-22-sirt-1-pathway-in-hepatic-cancer-cells
#1
Kishor Pant, Ajay K Yadav, Parul Gupta, Rakibul Islam, Anoop Saraya, Senthil K Venugopal
Butyrate is one of the short chain fatty acids, produced by the gut microbiota during anaerobic fermentation of dietary fibres. It has been shown that it can inhibit tumor progression via suppressing histone deacetylase and can induce apoptosis in cancer cells. However, the comprehensive pathway by which butyrate mediates apoptosis and growth arrest in cancer cells still remains unclear. In this study, the role of miR-22 in butyrate-mediated ROS release and induction of apoptosis was determined in hepatic cells...
March 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/28279944/adipose-tissue-nad-homeostasis-sirtuins-and-poly-adp-ribose-polymerases-important-players-in-mitochondrial-metabolism-and-metabolic-health
#2
REVIEW
Riikka Jokinen, Sini Pirnes-Karhu, Kirsi H Pietiläinen, Eija Pirinen
Obesity, a chronic state of energy overload, is characterized by adipose tissue dysfunction that is considered to be the major driver for obesity associated metabolic complications. The reasons for adipose tissue dysfunction are incompletely understood, but one potential contributing factor is adipose tissue mitochondrial dysfunction. Derangements of adipose tissue mitochondrial biogenesis and pathways associate with obesity and metabolic diseases. Mitochondria are central organelles in energy metabolism through their role in energy derivation through catabolic oxidative reactions...
February 27, 2017: Redox Biology
https://www.readbyqxmd.com/read/28269152/graph-based-sinogram-denoising-for-tomographic-reconstructions
#3
Faisal Mahmood, Nauman Shahid, Pierre Vandergheynst, Ulf Skoglund
Limited data and low-dose constraints are common problems in a variety of tomographic reconstruction paradigms, leading to noisy and incomplete data. Over the past few years, sinogram denoising has become an essential preprocessing step for low-dose Computed Tomographic (CT) reconstructions. We propose a novel sinogram denoising algorithm inspired by signal processing on graphs. Graph-based methods often perform better than standard filtering operations since they can exploit the signal structure. This makes the sinogram an ideal candidate for graph based denoising since it generally has a piecewise smooth structure...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28250276/atractylenolide-iii-enhances-energy-metabolism-by-increasing-the-sirt-1-and-pgc1%C3%AE-expression-with-ampk-phosphorylation-in-c2c12-mouse-skeletal-muscle-cells
#4
Mi Young Song, Hyo Won Jung, Seok Yong Kang, Yong-Ki Park
Targeting energy expenditure provides a potential alternative strategy for achieving energy balance to combat obesity and the development of type 2 diabetes mellitus (T2DM). In the present study, we investigated whether atractylenolide III (AIII) regulates energy metabolism in skeletal muscle cells. Differentiated C2C12 myotubes were treated with AIII (10, 20, or 50 µM) or metformin (2.5 mM) for indicated times. The levels of glucose uptake, the expressions of key mitochondrial biogenesis-related factors and their target genes were measured in C2C12 myotubes...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28239158/synthesis-of-the-novel-parp-1-inhibitor-ag-690-11026014-and-its-protective-effects-on-angiotensin-ii-induced-mouse-cardiac-remodeling
#5
Guo-Shuai Feng, Cui-Ge Zhu, Zhuo-Ming Li, Pan-Xia Wang, Yi Huang, Min Liu, Ping He, Lan-Lan Lou, Shao-Rui Chen, Pei-Qing Liu
We previously identified AG-690/11026014 (6014) as a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor that effectively prevented angiotensin II (Ang II)-induced cardiomyocyte hypertrophy. In the present study, we reported a new synthesis route for 6014, and investigated its protective effects on Ang II-induced cardiac remodeling and cardiac dysfunction and the underlying mechanisms in mice. We designed a new synthesis route to obtain a sufficient quantity of 6014 for this in vivo study. C57BL/6J mice were infused with Ang II and treated with 6014 (10, 30, 90 mg·kg(-1)·d(-1), ig) for 4 weeks...
February 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28237869/the-role-of-image-guided-therapy-in-the-management-of-colorectal-cancer-metastatic-disease
#6
REVIEW
Thierry de Baere, Lambros Tselikas, Steven Yevich, Valérie Boige, Frederic Deschamps, Michel Ducreux, Diane Goere, France Nguyen, David Malka
The European Society for Medical Oncology (ESMO) have stressed that the option for treating oligometastatic disease is a strategy of local ablative therapy, the goal of which is to improve disease control. The spectrum of the local ablative therapy toolbox described by the ESMO includes surgical R0 resection, percutaneous ablation and intra-arterial therapies, the choice of treatment being left to the multidisciplinary team. Interventional therapy involving image-guided treatment offers the possibility of less invasive treatments for colorectal cancer metastases in the liver, lung and bone by preserving from toxicity distant healthy organs or even parts of the diseased organs...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28236057/regulation-of-sirtuin-3-mediated-deacetylation-of-cyclophilin-d-attenuated-cognitive-dysfunction-induced-by-sepsis-associated-encephalopathy-in-mice
#7
Fan Sun, Yanna Si, Hongguang Bao, Yajie Xu, XiaoXiao Pan, Lingqing Zeng, Ling Jing
The present study aimed to investigate cognitive dysfunction in the hippocampus induced by sepsis-associated encephalopathy (SAE) via acetylation of cyclophilin D (CypD) and opening of mitochondrial permeability transition pore. It also explored whether activating sirtuin 3 (SIRT3) can mediate deacetylation of CypD and prevent the development of SAE. Male mice were randomly assigned to six groups: sham group, cecal ligation puncture group, CypD siRNA transfection (CypD-si) group, CypD control siRNA transfection (CypD-c) group, SIRT3 overexpression vector pcDNA3...
February 25, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28235630/comprehensive-immunohistochemical-analysis-of-histone-deacetylases-in-pancreatic-neuroendocrine-tumors-hdac5-as-a-predictor-of-poor-clinical-outcome
#8
Eckhard Klieser, Romana Urbas, Stefan Stättner, Florian Primavesi, Tarkan Jäger, Adam Dinnewitzer, Christian Mayr, Tobias Kiesslich, Klaus Holzmann, Pietro Di Fazio, Daniel Neureiter, Stefan Swierczynski
Epigenetic factors contribute to carcinogenesis, tumor promotion and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gene silencing. Many cancer entities feature over-expression of HDACs. Currently, the role of HDACs in pancreatic neuroendocrine tumors (pNETs) is unclear. We analyzed expression patterns of all HDAC classes (Class I, IIA, IIB, III & IV) in five human tissue microarrays (TMA) representing 57 pNETs resected between 1997 and 2013 and corresponding control tissue...
February 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28227381/graph-based-sinogram-denoising-for-tomographic-reconstructions
#9
Faisal Mahmood, Nauman Shahid, Pierre Vandergheynst, Ulf Skoglund, Faisal Mahmood, Nauman Shahid, Pierre Vandergheynst, Ulf Skoglund, Faisal Mahmood, Ulf Skoglund, Nauman Shahid, Pierre Vandergheynst
Limited data and low-dose constraints are common problems in a variety of tomographic reconstruction paradigms, leading to noisy and incomplete data. Over the past few years, sinogram denoising has become an essential preprocessing step for low-dose Computed Tomographic (CT) reconstructions. We propose a novel sinogram denoising algorithm inspired by signal processing on graphs. Graph-based methods often perform better than standard filtering operations since they can exploit the signal structure. This makes the sinogram an ideal candidate for graph based denoising since it generally has a piecewise smooth structure...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28202430/vespro-an-individual-patient-data-prospective-meta-analysis-of-selective-internal-radiation-therapy-versus-sorafenib-for-advanced-locally-advanced-or-recurrent-hepatocellular-carcinoma-of-the-sarah-and-sirvenib-trials
#10
Val Gebski, Emma Gibbs, Mihir Gandhi, Gilles Chatellier, Aurelia Dinut, Helena Pereira, Pierce Kh Chow, Valérie Vilgrain
BACKGROUND: Untreated advanced hepatocellular carcinoma (HCC) has an overall poor prognosis. Currently there are 2 ongoing prospective randomized controlled trials that are evaluating the efficacy and safety of sorafenib and selective internal radiation therapy (SIRT) with yttrium-90 resin microspheres in patients with advanced HCC. The SorAfenib versus Radioembolisation in Advanced Hepatocellular carcinoma (SARAH; 459 patients) trial is being performed in Europe and the SIRt VErsus SorafeNIB (SIRveNIB; 360 patients) trial in the Asia Pacific region...
February 15, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28197553/the-role-of-sirt1-in-epileptogenesis
#11
Alicia M Hall, Gary P Brennan, Tiffany M Nguyen, Akanksha Singh-Taylor, Hyun-Seung Mun, Mary J Sargious, Tallie Z Baram
The mechanisms by which brain insults lead to subsequent epilepsy remain unclear. Insults, including trauma, stroke, tumors, infections, and long seizures [status epilepticus (SE)], create a neuronal state of increased metabolic demand or decreased energy supply. Neurons express molecules that monitor their metabolic state, including sirtuins (Sirts). Sirtuins deacetylate cytoplasmic proteins and nuclear histones, and their epigenetic modulation of the chromatin governs the expression of many genes, influencing neuronal properties...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28197299/sirtuins-expression-and-their-role-in-retinal-diseases
#12
REVIEW
Sankarathi Balaiya, Khaled K Abu-Amero, Altaf A Kondkar, Kakarla V Chalam
Sirtuins have received considerable attention since the discovery that silent information regulator 2 (Sir2) extends the lifespan of yeast. Sir2, a nicotinamide adenine dinucleotide- (NAD-) dependent histone deacetylase, serves as both a transcriptional effector and energy sensor. Oxidative stress and apoptosis are implicated in the pathogenesis of neurodegenerative eye diseases. Sirtuins confer protection against oxidative stress and retinal degeneration. In mammals, the sirtuin (SIRT) family consists of seven proteins (SIRT1-SIRT7)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28177190/improving-patient-selection-for-selective-internal-radiation-therapy-of-intra-hepatic-cholangiocarcinoma-a-meta-regression-study
#13
Alessandro Cucchetti, Alberta Cappelli, Cristina Mosconi, Jian-Hong Zhong, Matteo Cescon, Antonio Daniele Pinna, Rita Golfieri
BACKGROUND & AIMS: Selective Internal Radiation Therapy (SIRT) is emerging as a potential therapy for unresectable intra-hepatic cholangiocarcinoma (iCCA), able to prolong life-expectancy. Aim of the study was to collect available literature, meta-analyze data and results and investigate sources of heterogeneity through a meta-regression approach, before suggesting SIRT as a valuable option. METHODS: A systematic review of studies published until 1 September 2016 in PubMed and Scopus databases was performed...
February 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28168178/aging-related-correlation-between-serum-sirtuin-1-activities-and-basal-metabolic-rate-in-women-but-not-in-men
#14
Hee Jae Lee, Soo Jin Yang
Sirtuin (SIRT) is a main regulator of metabolism and lifespan, and its importance has been implicated in the prevention against aging-related diseases. The purpose of this study was to identify the pattern of serum SIRT1 activity according to age and sex, and to investigate how serum SIRT1 activity is correlated with other metabolic parameters in Korean adults. The Biobank of Jeju National University Hospital, a member of the Korea Biobank Network, provided serum samples from 250 healthy adults. Aging- and metabolism-related factors were analyzed in serum, and the data were compared by the stratification of age and sex...
January 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28164517/prognostic-and-predictive-role-of-sirtuin1-expression-in-lung-adenocarcinoma
#15
Jun Wang, Changli Wang
BACKGROUND: SIRT1 is the homologue of sir2 in mammals, which is a nicotinamide adenine dinucleotide (NAD+) dependent histone deacetylase. Several studies have reported that the overexpression of Sirtuin1 (SIRT1) was associated with poor prognosis in various human cancers. However, little is known regarding the prognostic value of SIRT1 in lung adenocarcinoma. METHODS: SIRT 1 expression in tissues of 60 lung adenocarcinoma (LAC) patients was evaluated using immunohistochemistry...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28153032/analyses-of-caspase-1-regulated-transcriptomes-in-various-tissues-lead-to-identification-of-novel-il-1%C3%AE-il-18-and-sirtuin-1-independent-pathways
#16
Ya-Feng Li, Gayani Nanayakkara, Yu Sun, Xinyuan Li, Luqiao Wang, Ramon Cueto, Ying Shao, Hangfei Fu, Candice Johnson, Jiali Cheng, Xiongwen Chen, Wenhui Hu, Jun Yu, Eric T Choi, Hong Wang, Xiao-Feng Yang
BACKGROUND: It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can significantly impact the transcriptome. However, it is not known whether all the effects exerted by caspase-1 on transcriptome are mediated only by its well-known substrates. Therefore, we hypothesized that the effects of caspase-1 on transcriptome may be partially independent from IL-1β, IL-18, and Sirt-1...
February 2, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28135086/thienopyrimidinone-based-sirtuin-2-sirt2-selective-inhibitors-bind-in-the-ligand-induced-selectivity-pocket
#17
Sandeep Sundriyal, Sébastien Moniot, Zimam Mahmud, Shang Yao, Paolo Di Fruscia, Christopher R Reynolds, David T Dexter, Michael J E Sternberg, Eric W-F Lam, Clemens Steegborn, Matthew J Fuchter
Sirtuins (SIRTs) are NAD-dependent deacylases, known to be involved in a variety of pathophysiological processes and thus remain promising therapeutic targets for further validation. Previously, we reported a novel thienopyrimidinone SIRT2 inhibitor with good potency and excellent selectivity for SIRT2. Herein, we report an extensive SAR study of this chemical series and identify the key pharmacophoric elements and physiochemical properties that underpin the excellent activity observed. New analogues have been identified with submicromolar SIRT2 inhibtory activity and good to excellent SIRT2 subtype-selectivity...
February 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28130175/up-regulation-of-sirt6-in-the-hippocampus-induced-rats-with-depression-like-behavior-via-the-block-akt-gsk3%C3%AE-signaling-pathway
#18
Qiang Mao, Xue Gong, Chanjuan Zhou, Zhe Tu, Libo Zhao, Ling Wang, Xinfa Wang, Lu Sun, Jinjun Xia, Bin Lian, Jianjun Chen, Jun Mu, Deyu Yang, Peng Xie
Major depression is the leading cause of disability worldwide, which is associated with diverse alterations in brain such as neuro-inflammation, synaptic dysfunction, and cognitive deficit. Accumulating evidences suggest sirtuins (SIRTs) are involved in brain developmental disorders, metabolic diseases and play a key role in cognition and synaptic plasticity, yet the role in mood regulation remains controversial. Hence, Western blotting and RT-qPCR were used to investigate whether SIRTs (SIRT1-7) expression levels were altered in the hippocampus of rats, which followed 5 weeks of chronic unpredictable mild stress (CUMS) treatment, the results showed depressive-like behaviors: like body weight, forced swim test and sucrose preference test and SIRT6 was a significant increase in the hippocampal of CUMS rats...
April 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28128062/a-review-on-sirtuins-in-diabetes
#19
R Aditya, A Ravi Kiran, D Sai Varma, Ravichandra Vemuri, Rohit Gundamaraju
BACKGROUND: Type-2 Diabetes is a long lasting disease characterized by high glucose concentration in the blood due to insulin resistance. One of the recent treatment strategies is using activators against SIRT-1, which has been in clinical trials. Hence, it is necessary to know the effects of the SIRT-1 modulators against various metabolic pathways. METHODS: Many cellular processes, including insulin secretion, cell cycle, and apoptosis are imperatively regulated by a family of mediators called SIRTuins...
January 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28127745/5-fluorouracil-causes-endothelial-cell-senescence-potential-protective-role-of-glucagon-like-peptide-1
#20
Paola Altieri, Roberto Murialdo, Chiara Barisione, Edoardo Lazzarini, Silvano Garibaldi, Patrizia Fabbi, Clarissa Ruggeri, Silvia Borile, Federico Carbone, Andrea Armirotti, Marco Canepa, Alberto Ballestrero, Claudio Brunelli, Fabrizio Montecucco, Pietro Ameri, Paolo Spallarossa
BACKGROUND AND PURPOSE: 5-fluorouracil (5FU) and its prodrug, capecitabine, can damage endothelial cells, whilst endothelial integrity is preserved by glucagon-like peptide 1 (GLP-1). Here, we studied the effect of 5FU on endothelial senescence and whether GLP-1 antagonizes it. EXPERIMENTAL APPROACH: EA.hy926 cells were exposed to 5FU or sera from patients taking capecitabine, with or without pre-incubation with GLP-1. Senescence was identified by expression of senescence-associated β-galactosidase and p16(INK4a) and reduced cell proliferation...
January 27, 2017: British Journal of Pharmacology
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