keyword
MENU ▼
Read by QxMD icon Read
search

oesophageal carcinoma

keyword
https://www.readbyqxmd.com/read/28213876/update-on-neoadjuvant-regimens-for-patients-with-operable-oesophageal-gastrooesophageal-junction-adenocarcinomas-and-squamous-cell-carcinomas
#1
REVIEW
Samantha J Cox, Sean M O'Cathail, Bernadette Coles, Tom Crosby, Somnath Mukherjee
Survival outcomes following multimodal treatment of operable oesophageal and gastrooesophageal cancer remain disappointingly poor. Although an appreciation of the impact of both tumour location and histological subtype is now shaping the design of clinical trials, there has been a lack of consensus of the optimal neoadjuvant treatment strategy. This update article will review recent advances in the use of both neoadjuvant chemotherapy and chemoradiotherapy. The emerging role of PET imaging to direct appropriate neoadjuvant treatment regimens and the additive benefit of biological agents are also discussed...
January 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28199649/does-cervical-lymph-node-recurrence-after-oesophagectomy-or-definitive-chemoradiotherapy-for-thoracic-oesophageal-squamous-cell-carcinoma-benefit-from-salvage-treatment
#2
Xiaoli Yuan, Jiahua Lv, Hang Dong, Jiuhui Wang
No abstract text is available yet for this article.
February 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28188753/mir-498-in-oesophageal-squamous-cell-carcinoma-clinicopathological-impacts-and-functional-interactions
#3
Farhadul Islam, Vinod Gopalan, Simon Law, Johnny Cheuk-On Tang, Kwok-Wah Chan, Alfred King-Yin Lam
MicroRNA-498 plays a crucial role in progression of many carcinomas. The signalling pathways that miR-498 modulates carcinogenesis are still unknown. Also, miR-498 associated molecular pathogenesis has never been studied in the oesophageal squamous cell carcinoma (ESCC). Herein, we aimed to examine the expression and functional roles of miR-498 in the ESCC as well as its influences on the clinicopathological features in patients with ESCC. Expression of miR-498 was investigated in 93 ESCC tissues and five ESCC cell lines using quantitative real-time polymerase chain reaction...
February 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28188605/-cancer-and-mycoses-and-literature-review
#4
M Develoux
Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Candida sp are more prevalent in potentially malignant disorder and cancer of the oral mucosa. Other epidemiological evidence of a link between Candida infection and cancer is what is observed in patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)...
February 11, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28120720/the-role-of-epidermal-growth-factor-receptor-in-the-management-of-gastrointestinal-carcinomas-present-status-and-future-perspectives
#5
Malik Quasir Mahmood, Shakti Dhar Shukla, Kamal Dua, Madhur D Shastri
BACKGROUND: The global burden of gastrointestinal cancers, including colorectal, stomach, and esophageal cancers is rising steadily. Several therapeutic approaches have been considered for the treatment of GI carcinomas. However, none showed to halt or cure the disease. There is a need to develop effective targeted molecular therapies; mainly to overcome the adverse effects of currently used treatment regimens, as well as, to benefit a large proportion of cancer patients who do not respond well to chemotherapeutics...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28120520/chemoradiation-combined-with-regional-hyperthermia-for-advanced-oesophageal-cancer-a-systematic-review-and-meta-analysis
#6
REVIEW
Y Hu, Z Li, D-H Mi, N Cao, S-W Zu, Z-Z Wen, X-L Yu, Y Qu
WHAT IS KNOWN AND OBJECTIVE: Hyperthermia is an effective treatment modality that augments the anticancer effects of radiotherapy and chemotherapy. Hyperthermia-chemo-radiotherapy (HCRT) is a combination therapy that can strengthen anticancer effects through a synergistic interaction between heat, chemotherapy and radiation. Here, we carried out a systematic review and meta-analysis to evaluate the clinical efficacy and safety of chemoradiation combined with regional hyperthermia (HCRT) for oesophageal carcinoma...
January 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28105699/neat1-a-novel-cancer-related-long-non-coding-rna
#7
REVIEW
Xin Yu, Zheng Li, Heyi Zheng, Matthew T V Chan, William Ka Kei Wu
Aberrant overexpression of the long non-coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast, NEAT1 is downregulated in acute promyelocytic leukaemia where it promotes leucocyte differentiation. In this review, we provide an overview of current evidence concerning the oncogenic role and potential clinical utilities of NEAT1...
January 19, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28059068/cdk4-6-or-mapk-blockade-enhances-efficacy-of-egfr-inhibition-in-oesophageal-squamous-cell-carcinoma
#8
Jin Zhou, Zhong Wu, Gabrielle Wong, Eirini Pectasides, Ankur Nagaraja, Matthew Stachler, Haikuo Zhang, Ting Chen, Haisheng Zhang, Jie Bin Liu, Xinsen Xu, Ewa Sicinska, Francisco Sanchez-Vega, Anil K Rustgi, J Alan Diehl, Kwok-Kin Wong, Adam J Bass
Oesophageal squamous cell carcinoma is a deadly disease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alterations pointing to candidate therapeutic targets, including recurrent amplification of the gene encoding receptor tyrosine kinase epidermal growth factor receptor (EGFR). Here, we demonstrate that EGFR-targeting small-molecule inhibitors have efficacy in EGFR-amplified oesophageal squamous cell carcinoma (ESCC), but may become quickly ineffective. Resistance can occur following the emergence of epithelial-mesenchymal transition and by reactivation of the mitogen-activated protein kinase (MAPK) pathway following EGFR blockade...
January 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#9
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 12, 2017: Nature
https://www.readbyqxmd.com/read/28041813/target-volume-delineation-for-radical-radiotherapy-of-early-oesophageal-carcinoma-in-elderly-patients
#10
J Su, S Zhu, Z Liu, Y Zhao, C Song
PURPOSE: To compare the prognosis of elderly patients with early oesophageal carcinoma between radical elective nodal prophylactic irradiation and involved-field irradiation and to estimate the failure modes and adverse effects, then to provide the patients the safe and individual therapeutic regimens. MATERIAL AND METHODS: The charts of 96 patients aged 65 and over with early stage oesophageal carcinoma receiving radical radiotherapy in our department were retrospectively analysed...
December 29, 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28040757/surgery-for-malignant-pulmonary-nodules-in-patients-with-a-history-of-oesophageal-cancer
#11
Ryu Kanzaki, Toru Kimura, Tomohiro Kawamura, Soichiro Funaki, Yasushi Shintani, Masato Minami, Makoto Yamasaki, Masaki Mori, Yuichiro Doki, Meinoshin Okumura
OBJECTIVES: The objective of this study is to analyse the short- and long-term results of surgery for malignant pulmonary nodules in patients with a history of oesophageal cancer (EC) in order to assess the significance of surgery in these patients. METHODS: The data of 28 consecutive patients with a history of EC who underwent pulmonary resection for malignant pulmonary nodules were reviewed. The perioperative and long-term results were analysed. RESULTS: The histological type of oesophageal cancer was squamous cell carcinoma in all of the patients...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28036160/bile-acids-a-potential-role-in-the-pathogenesis-of-pharyngeal-malignancy
#12
Z Shellman, A Aldhahrani, B Verdon, M Mather, V Paleri, J Wilson, J Pearson, C Ward, J Powell
OBJECTIVE: Gastro-oesophageal reflux disease is thought to be a risk factor for head and neck malignancies. Bile acids are one of the principle components of gastric refluxate and have previously been implicated in the development of oesophageal and bowel malignancies. There is clear evidence that bile acids reflux into the laryngopharynx. Despite this, the carcinogenic properties of bile acids in this area are yet to be fully identified. We therefore investigated the potential role of bile acids in pharyngeal malignancy, through the highly conserved process of epithelial-mesenchymal transition (EMT)...
December 30, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28011472/kif11-is-required-for-spheroid-formation-by-oesophageal-and-colorectal-cancer-cells
#13
Takeharu Imai, Naohide Oue, Kazuhiro Sentani, Naoya Sakamoto, Naohiro Uraoka, Hiroyuki Egi, Takao Hinoi, Hideki Ohdan, Kazuhiro Yoshida, Wataru Yasui
BACKGROUND: Oesophageal squamous cell carcinoma (ESCC) and colorectal cancer (CRC) are common types of human cancer. Spheroid colony formation is used to characterize cancer stem cell (CSCs). In the present study, we analyzed the significance of kinesin family 11 (KIF11 in human ESCC and CRC. MATERIALS AND METHODS: Expression of KIF11 in 105 ESCC and 100 CRC cases was determined using immunohistochemistry. RNA interference was used to inhibit KIF11 expression in ESCC and CRC cell lines...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28008773/radiotherapy-response-evaluation-using-fdg-pet-ct-established-and-emerging-applications
#14
Helen Cliffe, Chirag Patel, Robin Prestwich, Andrew Scarsbrook
Radiation therapy is a common component of curative cancer treatment. However, there is a significant incidence of treatment failure. In these cases salvage surgical options are sometimes appropriate. Accurate assessment of response and early recognition of treatment success or failure is therefore critical to guide treatment decisions and impacts on survival and the morbidity of treatment. Traditionally, treatment response has depended upon anatomical measurement of disease. However, this may not correlate well with the presence of disease, especially after radiotherapy...
December 23, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27938785/review-surveillance-of-patients-with-barrett-oesophagus
#15
REVIEW
Sielte Maes, Prateek Sharma, Raf Bisschops
There has been a rapid increase in the incidence of oesophageal adenocarcinoma in most Western countries over the past thirty years. Barrett's oesophagus (BE) is a common premalignant lesion of oesophageal adenocarcinoma, although the risk of developing cancer in BE remains low. Therefore, screening is not recommended in the general population. Surveillance of BE is recommended to detect high grade dysplasia or carcinoma in an early stage, although there is no clear evidence that surveillance leads to a reduced mortality...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27927666/epigenetic-biomarkers-in-progression-from-non-dysplastic-barrett-s-oesophagus-to-oesophageal-adenocarcinoma-a-systematic-review-protocol
#16
T Nieto, C L Tomlinson, J Dretzke, S Bayliss, M Dilworth, A D Beggs, O Tucker
INTRODUCTION: Barrett's oesophagus (BO), a metaplastic condition affecting the lower oesophagus due to long-standing gastro-oesophageal reflux and chronic inflammation, is a precursor lesion for oesophageal adenocarcinoma (OADC). There is no clinical test to predict which patients with BO will progress to OADC. The British Society of Gastroenterology recommends endoscopic surveillance of patients with BO. Epigenetic changes have been well characterised in the neoplastic progression of ulcerative colitis to colonic carcinoma, another gastrointestinal cancer associated with chronic inflammation...
December 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27924820/integrin-%C3%AE-7-is-a-functional-cancer-stem-cell-surface-marker-in-oesophageal-squamous-cell-carcinoma
#17
Xiao-Yan Ming, Li Fu, Li-Yi Zhang, Yan-Ru Qin, Ting-Ting Cao, Kwok Wah Chan, Stephanie Ma, Dan Xie, Xin-Yuan Guan
Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 (ITGA7) is characterized as a potential cancer stem cell (CSC) marker. Clinical data show that a high frequency of ITGA7(+) cells in OSCC tissues is significantly associated with poor differentiation, lymph node metastasis and worse prognosis...
December 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27920642/recurrent-complete-pharyngo-oesophageal-stricture-treated-by-multidisciplinary-anterograde-retrograde-endoscopic-dilation
#18
Paulo Castro Soares, Salim Bouayed, Pavel Dulguerov, Jean-Louis Frossard
Complete pharyngo-oesophageal stricture (PES) after radiotherapy for head and neck cancer is a relatively rare and difficult complication to manage. Historically this condition has been treated surgically, but endoscopic approaches are now available. We present a 61-year-old man with an epidermoid carcinoma of the supraglottic stage and a micro-invasive epidermoid carcinoma of the oropharynx treated surgically and subsequently by adjuvant radiotherapy. Eight months after the end of the radiotherapy, a complete PES was diagnosed and treated with a combined anterograde-retrograde endoscopic dilation (CARD)...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27909902/obesity-and-oesophageal-cancer
#19
Katharina Nimptsch, Annika Steffen, Tobias Pischon
A substantial increase in the incidence of oesophageal adenocarcinoma has been observed in Western countries during the past 30 years, which may be related to the parallel rise of the obesity prevalence. On the other hand, incidence rates of oesophageal squamous cell carcinomas, the other major histological type of oesophageal cancer, have remained relatively stable. Epidemiological research of the past decades has identified obesity as risk factor for oesophageal adenocarcinoma. Studies investigating general obesity as assessed by body mass index (BMI) provide evidence for a strong positive association with oesophageal adenocarcinoma...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27891444/paclitaxel-induced-acute-st-elevation-myocardial-infarction-a-rare-case-report
#20
Gautam Rawal, Sankalp Yadav, Raj Kumar
Paclitaxel, is a frequently used anti-neoplastic agent and is included in various chemotherapy regimens. The life threatening cardio toxicity associated with its use and the still unclear pathophysiology, has limited the use of this drug. Acute myocardial infarction is a rare adverse event associated with this drug. We report a case of acute ST-elevation myocardial infarction induced by paclitaxel infusion in a patient of oesophageal carcinoma who was saved by percutaneous primary intervention. The authors emphasize the awareness of this side effect of Paclitaxel among the clinicians...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
keyword
keyword
50185
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"