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https://www.readbyqxmd.com/read/28329246/lymphovascular-invasion-and-extracapsular-invasion-are-risk-factors-for-distant-recurrence-after-preoperative-chemoradiotherapy-and-oesophagectomy-in-patients-with-oesophageal-squamous-cell-carcinoma
#1
Po-Kuei Hsu, Ling-I Chien, Lei-Chi Wang, Teh-Ying Chou
OBJECTIVES: Patients with oesophageal squamous cell carcinoma have a high risk of disease recurrence even after trimodality treatments, which include preoperative chemoradiotherapy and oesophagectomy. We aimed to identify the histological factors that are associated with loco-regional and distant recurrence. METHODS: A retrospective review of a prospectively established database identified patients who received preoperative chemoradiotherapy and oesophagectomy for squamous cell carcinoma...
February 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28320382/laparoscopic-t-tube-feeding-jejunostomy-as-an-adjunct-to-staging-laparoscopy-for-upper-gastrointestinal-malignancies-the-technique-and-review-of-outcomes
#2
Sze Li Siow, Hans Alexander Mahendran, Chee Ming Wong, Nirumal Kumar Milaksh, Myo Nyunt
BACKGROUND: In recent years, staging laparoscopy has gained acceptance as part of the assessment of resectability of upper gastrointestinal (UGI) malignancies. Not infrequently, we encounter tumours that are either locally advanced; requiring neoadjuvant therapy or occult peritoneal disease that requires palliation. In all these cases, the establishment of enteral feeding during staging laparoscopy is important for patients' nutrition. This review describes our technique of performing laparoscopic feeding jejunostomy and the clinical outcomes...
March 20, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28314688/nivolumab-treatment-for-oesophageal-squamous-cell-carcinoma-an-open-label-multicentre-phase-2-trial
#3
Toshihiro Kudo, Yasuo Hamamoto, Ken Kato, Takashi Ura, Takashi Kojima, Takahiro Tsushima, Shuichi Hironaka, Hiroki Hara, Taroh Satoh, Satoru Iwasa, Kei Muro, Hirofumi Yasui, Keiko Minashi, Kensei Yamaguchi, Atsushi Ohtsu, Yuichiro Doki, Yuko Kitagawa
BACKGROUND: Nivolumab is a human monoclonal IgG4 antibody that inhibits programmed cell death protein 1 (PD-1) expressed on activated T cells. We investigated the safety and activity of nivolumab in patients with treatment-refractory oesophageal cancer. METHODS: We did an open-label, single-arm, multicentre phase 2 study. Eligible patients had advanced squamous-cell carcinoma, adenosquamous-cell carcinoma, or adenocarcinoma of the oesophagus refractory or intolerant to fluoropyrimidine-based, platinum-based, and taxane-based chemotherapy...
March 14, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28314263/significance-and-function-of-microrna-7-in-oesophageal-squamous-cell-carcinoma
#4
Keigo Hara, Tatsuya Miyazaki, Takehiko Yokobori, Tomonori Yoshida, Yuji Kumakura, Hiroaki Honjyo, Makoto Sakai, Makoto Sohda, Minoru Fukuchi, Hiroyuki Kuwano
BACKGROUND/AIM: We detected microRNA-7 (miR-7) as being specific for oesophageal squamous cell carcinoma (ESCC) by using database analysis. However, the significance of miR-7 in clinical ESCC remains unexplored. This study aimed to clarify the clinicopathological significance of miR-7 in ESCC, and investigate miR-7 function. MATERIALS AND METHODS: Quantitative TaqMan reverse transcription polymerase chain reaction was used to evaluate miR-7 expression in 85 ESCC samples to determine the clinicopathological significance of miR-7 expression...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28276285/gastric-conduit-obstruction-due-to-gastroduodenal-compression-a-new-complication-post-ivor-lewis-oesophagectomy
#5
Victoria A Perkins, Samuel McFerran, Ali Kordzadeh, Elias Sdralis, Bruno Lorenzi, Alexandros Charalabopoulos
INTRODUCTION: Oesophagectomy for oesophageal carcinoma carries a high risk of significant morbidity and mortality. Delayed gastric emptying is a relatively common complication following this procedure. A variety of medical, surgical and endoscopic strategies have been described to manage it. The vast majority of cases are related to post-operative pyloric dysfunction and are amenable to conventional management strategies. PATIENTS AND METHODS: We present a new case of a patient with a duodenal hiatus hernia resulting in extrinsic gastroduodenal compression by the massively distended gastric conduit as a cause of gastric outlet obstruction following laparoscopic-assisted Ivor-Lewis oesophagectomy 2 years previously...
March 9, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28270162/a-phase-ii-study-of-concurrent-chemoradiotherapy-combined-with-a-weekly-paclitaxel-and-5-fluorouracil-regimen-to-treat-patients-with-advanced-oesophageal-carcinoma
#6
Yi Xia, Yun-Hai Li, Yun Chen, Jun-Hua Zhang, Qi Liu, Jia-Ying Deng, Ta-Shan Ai, Han-Ting Zhu, Jian-Hong Fan, Harun Badakhshi, Kuai-le Zhao
BACKGROUND: A phase II study was performed to investigate the safety and efficacy of weekly doses of combined paclitaxel and 5-fluorouracil (5-FU) with concurrent radiation therapy, followed by 2 cycles of consolidation chemotherapy to treat patients with advanced oesophageal carcinoma. METHODS: The eligibility criteria included local, advanced, newly diagnosed and postoperative local regional lymph node metastasis; an Eastern Cooperative Oncology Group (ECOG) score of ≤ 2; and adequate organ function...
March 7, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28262586/surrogate-end-points-for-overall-survival-in-22-neoadjuvant-trials-of-gastro-oesophageal-cancers
#7
Fausto Petrelli, Gianluca Tomasello, Sandro Barni
BACKGROUND: The surrogacy between disease-free survival (DFS) and overall survival (OS) has been evaluated in patients with gastric cancer who received adjuvant chemotherapy. Similar analyses in patients who have undergone neoadjuvant chemoradiotherapy (CTRT) or chemotherapy (CT) for gastro-oesophageal (GE) cancer have not yet been performed. METHODS: We evaluated the correlation between DFS and pathologic complete response (pCR) with OS in patients with GE carcinomas enrolled in randomised studies...
March 2, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28262585/the-prognostic-and-potentially-predictive-value-of-the-laur%C3%A3-n-classification-in-oesophageal-adenocarcinoma
#8
Rosa T van der Kaaij, Petur Snaebjornsson, Francine E M Voncken, Jolanda M van Dieren, Edwin P M Jansen, Karolina Sikorska, Annemieke Cats, Johanna W van Sandick
AIM: To investigate the histological subtypes of oesophageal adenocarcinoma according to the Laurén classification (intestinal/diffuse/mixed) in relation to tumour response to neoadjuvant treatment, and in relation to patients' survival after potentially curative treatment. METHODS: Data were collected from all oesophageal adenocarcinoma patients who underwent potentially curative treatment in our institute between 1998 and 2014. Treatment consisted of neoadjuvant chemoradiotherapy (36-50 Gy) followed by an oesophagectomy or definitive chemoradiotherapy (50-50...
March 2, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28258029/incidence-trends-in-oesophageal-cancer-by-histological-type-an-updated-analysis-in-sweden
#9
Shao-Hua Xie, Fredrik Mattsson, Jesper Lagergren
BACKGROUND: We aimed to update incidence trends of oesophageal cancer by histological type in Sweden. METHODS: Using data from the Swedish Cancer Registry, we examined incidence trends of oesophageal cancer by histological types in individuals aged ≥50 years in 1970-2014 using log-linear joinpoint regressions. RESULTS: The age-standardised incidence rate of oesophageal adenocarcinoma in men increased on average by 3.0% per year in 1970-1994, followed by a more rapid increase of 13...
February 28, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28246477/can-patients-determine-the-level-of-their-dysphagia
#10
Hafiz Hamad Ashraf, Joanne Palmer, Harry Richard Dalton, Carolyn Waters, Thomas Luff, Madeline Strugnell, Iain Alexander Murray
AIM: To determine if patients can localise dysphagia level determined endoscopically or radiologically and association of gender, age, level and pathology. METHODS: Retrospective review of consecutive patients presenting to dysphagia hotline between March 2004 and March 2015 was carried out. Demographics, clinical history and investigation findings were recorded including patient perception of obstruction level (pharyngeal, mid sternal or low sternal) was documented and the actual level of obstruction found on endoscopic or radiological examination (if any) was noted...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28238461/-increased-glucose-uptake-by-seborrheic-keratosis-on-pet-scan
#11
C Merklen-Djafri, P Truntzer, S Hassler, B Cribier
BACKGROUND: Positron emission tomography (PET) is an examination based upon the uptake of a radioactive tracer by hypermetabolic cells. It is primarily used in tandem with tomodensitometry (PET-TDM) for cancer staging because of its high sensitivity and specificity for the detection of metastases. However, unusually high uptake may occur with benign tumours, including skin tumours. Herein, we report an extremely rare case of pathological uptake levels resulting from seborrhoeic keratosis...
February 23, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28237950/emergency-cricothyroidotomy-following-tracheobronchial-stenting
#12
Simon Robert Cavinato, Mike Denning, Brendan P Madden
A man aged 51 years was referred for tracheobronchial stenting after a poorly differentiated oesophageal carcinoma had progressed to cause stridor. Bronchoscopy revealed a left vocal cord palsy and tumour infiltration into the trachea. A tracheobronchial stent was placed, and after distal migration was endoscopically resited. Returning from theatre, the patient developed severe upper airway obstruction that progressed to cause CO2 narcosis and loss of consciousness. A rapid sequence induction was initiated, and a Glidescope revealed bilateral vocal cord palsy with severe oedema causing an inability to pass a tube or stylet...
February 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28213876/update-on-neoadjuvant-regimens-for-patients-with-operable-oesophageal-gastrooesophageal-junction-adenocarcinomas-and-squamous-cell-carcinomas
#13
REVIEW
Samantha J Cox, Sean M O'Cathail, Bernadette Coles, Tom Crosby, Somnath Mukherjee
Survival outcomes following multimodal treatment of operable oesophageal and gastrooesophageal cancer remain disappointingly poor. Although an appreciation of the impact of both tumour location and histological subtype is now shaping the design of clinical trials, there has been a lack of consensus of the optimal neoadjuvant treatment strategy. This update article will review recent advances in the use of both neoadjuvant chemotherapy and chemoradiotherapy. The emerging role of PET imaging to direct appropriate neoadjuvant treatment regimens and the additive benefit of biological agents are also discussed...
January 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28199649/does-cervical-lymph-node-recurrence-after-oesophagectomy-or-definitive-chemoradiotherapy-for-thoracic-oesophageal-squamous-cell-carcinoma-benefit-from-salvage-treatment
#14
Xiaoli Yuan, Jiahua Lv, Hang Dong, Jiuhui Wang
No abstract text is available yet for this article.
February 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28188753/mir-498-in-oesophageal-squamous-cell-carcinoma-clinicopathological-impacts-and-functional-interactions
#15
Farhadul Islam, Vinod Gopalan, Simon Law, Johnny Cheuk-On Tang, Kwok-Wah Chan, Alfred King-Yin Lam
MicroRNA-498 plays a crucial role in progression of many carcinomas. The signalling pathways that miR-498 modulates carcinogenesis are still unknown. Also, miR-498 associated molecular pathogenesis has never been studied in the oesophageal squamous cell carcinoma (ESCC). Herein, we aimed to examine the expression and functional roles of miR-498 in the ESCC as well as its influences on the clinicopathological features in patients with ESCC. Expression of miR-498 was investigated in 93 ESCC tissues and five ESCC cell lines using quantitative real-time polymerase chain reaction...
February 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28188605/-cancer-and-mycoses-and-literature-review
#16
M Develoux
Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Candida sp are more prevalent in potentially malignant disorder and cancer of the oral mucosa. Other epidemiological evidence of a link between Candida infection and cancer is what is observed in patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)...
February 11, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28120720/the-role-of-epidermal-growth-factor-receptor-in-the-management-of-gastrointestinal-carcinomas-present-status-and-future-perspectives
#17
Malik Quasir Mahmood, Shakti Dhar Shukla, Kamal Dua, Madhur D Shastri
BACKGROUND: The global burden of gastrointestinal cancers, including colorectal, stomach, and esophageal cancers is rising steadily. Several therapeutic approaches have been considered for the treatment of GI carcinomas. However, none showed to halt or cure the disease. There is a need to develop effective targeted molecular therapies; mainly to overcome the adverse effects of currently used treatment regimens, as well as, to benefit a large proportion of cancer patients who do not respond well to chemotherapeutics...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28120520/chemoradiation-combined-with-regional-hyperthermia-for-advanced-oesophageal-cancer-a-systematic-review-and-meta-analysis
#18
REVIEW
Y Hu, Z Li, D-H Mi, N Cao, S-W Zu, Z-Z Wen, X-L Yu, Y Qu
WHAT IS KNOWN AND OBJECTIVE: Hyperthermia is an effective treatment modality that augments the anticancer effects of radiotherapy and chemotherapy. Hyperthermia-chemo-radiotherapy (HCRT) is a combination therapy that can strengthen anticancer effects through a synergistic interaction between heat, chemotherapy and radiation. Here, we carried out a systematic review and meta-analysis to evaluate the clinical efficacy and safety of chemoradiation combined with regional hyperthermia (HCRT) for oesophageal carcinoma...
January 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28105699/neat1-a-novel-cancer-related-long-non-coding-rna
#19
REVIEW
Xin Yu, Zheng Li, Heyi Zheng, Matthew T V Chan, William Ka Kei Wu
Aberrant overexpression of the long non-coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast, NEAT1 is downregulated in acute promyelocytic leukaemia where it promotes leucocyte differentiation. In this review, we provide an overview of current evidence concerning the oncogenic role and potential clinical utilities of NEAT1...
April 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28059068/cdk4-6-or-mapk-blockade-enhances-efficacy-of-egfr-inhibition-in-oesophageal-squamous-cell-carcinoma
#20
Jin Zhou, Zhong Wu, Gabrielle Wong, Eirini Pectasides, Ankur Nagaraja, Matthew Stachler, Haikuo Zhang, Ting Chen, Haisheng Zhang, Jie Bin Liu, Xinsen Xu, Ewa Sicinska, Francisco Sanchez-Vega, Anil K Rustgi, J Alan Diehl, Kwok-Kin Wong, Adam J Bass
Oesophageal squamous cell carcinoma is a deadly disease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alterations pointing to candidate therapeutic targets, including recurrent amplification of the gene encoding receptor tyrosine kinase epidermal growth factor receptor (EGFR). Here, we demonstrate that EGFR-targeting small-molecule inhibitors have efficacy in EGFR-amplified oesophageal squamous cell carcinoma (ESCC), but may become quickly ineffective. Resistance can occur following the emergence of epithelial-mesenchymal transition and by reactivation of the mitogen-activated protein kinase (MAPK) pathway following EGFR blockade...
January 6, 2017: Nature Communications
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