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https://www.readbyqxmd.com/read/29684544/the-international-childhood-cardiovascular-cohort-i3c-consortium-outcomes-study-of-childhood-cardiovascular-risk-factors-and-adult-cardiovascular-morbidity-and-mortality-design-and-recruitment
#1
Alan R Sinaiko, David R Jacobs, Jessica G Woo, Lydia Bazzano, Trudy Burns, Tian Hu, Markus Juonala, Ronald Prineas, Olli Raitakari, Julia Steinberger, Elaine Urbina, Alison Venn, Cashell Jaquish, Terry Dwyer
Although it is widely thought that childhood levels of cardiovascular (CV) risk factors are related to adult CV disease, longitudinal data directly linking the two are lacking. This paper describes the design and organization of the International Childhood Cardiovascular Cohort Consortium Outcomes Study (i3C Outcomes), the first longitudinal cohort study designed to locate adults with detailed, repeated, childhood biological, physical, and socioeconomic measurements and a harmonized database. I3C Outcomes uses a Heart Health Survey (HHS) to obtain information on adult CV endpoints, using mail, email, telephone, and clinic visits in the United States (U...
April 20, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29683884/visit-to-visit-blood-pressure-variation-is-associated-with-outcomes-in-a-u-shaped-fashion-in-patients-with-myocardial-infarction-complicated-with-systolic-dysfunction-and-or-heart-failure-findings-from-the-ephesus-and-optimaal-trials
#2
João Pedro Ferreira, Kévin Duarte, Bertram Pitt, Kenneth Dickstein, John J V McMurray, Faiez Zannad, Patrick Rossignol
BACKGROUND: Visit-to-visit office blood pressure variation (BPV) has prognostic implications independent from mean BP across several populations in the cardiovascular field. The association of BPV with outcomes in patients with myocardial infarction (MI) with systolic dysfunction and/or heart failure is yet to be determined. METHODS: Two independent cohorts were assessed: the EPHESUS and the OPTIMAAL trials with a total of more than 12 000 patients. The primary outcome was all-cause death...
April 21, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29682736/medical-comorbidities-in-patients-with-lichen-planopilaris-a-retrospective-case-control-study
#3
Raymond M Fertig, Shasa Hu, Austin J Maddy, Alexandra Balaban, Nouf Aleid, Adam Aldahan, Antonella Tosti
BACKGROUND: Lichen planopilaris (LPP) is a rare inflammatory lymphocyte-mediated disease of the scalp considered to have an autoimmune pathogenesis. OBJECTIVES: To identify the prevalence of medical comorbidities in patients with classic LPP (CLPP) and frontal fibrosing alopecia (FFA). METHODS: The medical records of 206 LPP patients and 323 control patients were retrospectively reviewed for existing comorbidities. The control group consisted of 257 patients with androgenetic alopecia (ICD 9 = 704...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29681105/lethal-persistent-pulmonary-hypertension-of-the-newborn-in-bohring-opitz-syndrome
#4
Masaya Kibe, Satoshi Ibara, Hidehito Inagaki, Takema Kato, Hiroki Kurahashi, Toshiro Ikeda
Bohring-Opitz syndrome (BOS) is a rare disease with a number of characteristic features, including hypertelorism, prominent metopic suture, exophthalmos, cleft palate, abnormal posture, and developmental retardation. Here, we report a BOS patient presenting with lethal persistent pulmonary hypertension of the newborn (PPHN) and inspiratory respiratory failure. The female infant was treated with nitric oxide and vasodilator, which did not improve her condition. The inspiratory respiratory failure required management with deep sedation...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29680866/toward-hypertension-prediction-based-on-ppg-derived-hrv-signals-a-feasibility-study
#5
Kun-Chan Lan, Paweeya Raknim, Wei-Fong Kao, Jyh-How Huang
Heart rate variability (HRV) is often used to assess the risk of cardiovascular disease, and data on this can be obtained via electrocardiography (ECG). However, collecting heart rate data via photoplethysmography (PPG) is now a lot easier. We investigate the feasibility of using the PPG-based heart rate to estimate HRV and predict diseases. We obtain three months of PPG-based heart rate data from subjects with and without hypertension, and calculate the HRV based on various forms of time and frequency domain analysis...
April 21, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29680418/uvulopalatopharyngoplasty-reduces-the-incidence-of-cardiovascular-complications-caused-by-obstructive-sleep-apnea-results-from-the-national-insurance-service-survey-2007-2014
#6
Heung Man Lee, Hyo Yeol Kim, Jeffrey D Suh, Kyung-Do Han, Jin Kook Kim, Young Chang Lim, Seok-Chan Hong, Jae Hoon Cho
OBJECTIVE: Untreated obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease including myocardial infarction (MI), congestive heart failure (CHF), and atrial fibrillation (AF). Continuous positive airway pressure (CPAP) is an effective treatment for OSA; however, compliance with CPAP can be challenging for some patients. The objective of this study was to investigate whether uvulopalatopharyngoplasty (UPPP) reduced the risk of cardiovascular complications for patients with OSA...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29679405/who-you-are-and-where-you-live-can-determine-how-long-you-live-what-nurses-need-to-know-about-cardiovascular-disease-among-low-income-urban-dwelling-minority-communities
#7
EDITORIAL
Diana-Lyn Baptiste
Urban populations across the globe face unique health challenges in relationship to gender, race, geographical location and socioeconomic status. The global burden of cardiovascular disease is growing problem accounting for 17.3 million deaths in 2013 and projected to increase to 23.6 million by 2030 (American Heart Association, 2017; World Health Organization, 2018). Like many other countries, in the United States, cardiovascular disease is endemic, remaining the greatest cause of hospitalization and mortality; attributing to more than 45% of deaths among American adults (American Heart Association, 2017)...
April 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679302/association-of-abnormal-serum-potassium-levels-with-arrhythmias-and-cardiovascular-mortality-a-systematic-review-and-meta-analysis-of-observational-studies
#8
REVIEW
Liesa K Hoppe, Dana C Muhlack, Wolfgang Koenig, Prudence R Carr, Hermann Brenner, Ben Schöttker
PURPOSE: To provide the first systematic review and meta-analysis of observational studies on the association of abnormal serum potassium and cardiovascular outcomes. METHODS: Medline and ISI Web of Knowledge were systematically searched from inception until November 24, 2017. Data synthesis of relevant studies was performed using random effects model meta-analyses. RESULTS: Meta-analyses included 310,825 participants from 24 studies. In the older general population, low serum potassium was associated with a 1...
April 20, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29679294/gender-differences-in-home-based-cardiac-rehabilitation-of-post-percutaneous-coronary-intervention-patients
#9
Yong Hwan Kim, Wi-Young So
Cardiac rehabilitation (CR) is a structured program for the prevention of secondary cardiovascular disease (CVD) and related diseases, such as hypertension, diabetes, and obesity. This study aimed to investigate whether there are gender differences after 9 months of home-based cardiac rehabilitation program in post-percutaneous coronary intervention patients. A total of 114 (58.29 ± 10.33 years) men and 30 (60.90 ± 9.32 years) women were enrolled in the CR program. The program included three visits: initial, 4th month (follow-up), and 9th month (final) visits at a CR center...
April 20, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29678648/determinants-of-health-related-quality-of-life-1-year-after-pulmonary-thromboendarterectomy
#10
Oksana Kamenskaya, Asya Klinkova, Irina Loginova, Alexander Chernyavskiy, Alexander Edemskiy, Vladimir V Lomivorotov, Alexander Karaskov
AIM: Pulmonary thromboendarterectomy (PTE) is a recognized treatment for patients with chronic thromboembolic pulmonary hypertension (CTEPH), with good long-term haemodynamic results. The aim of this study was to test the hypothesis that the dynamics of health-related quality of life (QoL), 1 year after PTE, depends both on the clinical determinants associated with the underlying disease and the adverse events occurring in the early postoperative period. METHODS: This prospective cohort study included 136 patients with CTEPH...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29678287/novel-mechanisms-of-g-protein-coupled-receptors-functions-at-1-angiotensin-receptor-acts-as-a-signaling-hub-and-focal-point-of-receptor-cross-talk
#11
REVIEW
András D Tóth, Gábor Turu, László Hunyady, András Balla
AT1 angiotensin receptor (AT1 R), a prototypical G protein-coupled receptor (GPCR), is the main receptor, which mediates the effects of the renin-angiotensin system (RAS). AT1 R plays a crucial role in the regulation of blood pressure and salt-water homeostasis, and in the development of pathological conditions, such as hypertension, heart failure, cardiovascular remodeling, renal fibrosis, inflammation, and metabolic disorders. Stimulation of AT1 R leads to pleiotropic signal transduction pathways generating arrays of complex cellular responses...
April 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29677972/reflection-on-mobile-applications-for-blood-pressure-management-a-systematic-review-on-potential-effects-and-initiatives
#12
Reyhaneh Mohammadi, Movahhedeh Ayatolahi Tafti, Soodabeh Hoveidamanesh, Reza Ghanavati, Omid Pournik
INTRODUCTION: Ischemic heart disease and stroke have been considered as the first global leading cause of death in last decades [1]. Blood pressure (BP) management is one of the easiest ways suggested for preventing and controlling cardiovascular diseases before the patient develops complications and death-following outcomes. Appearance of technology advancements in the health system has motivated researchers and health providers to study its different aspects and applications in order to improve disease prevention and management...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677012/inverse-correlation-between-daily-outdoor-temperature-and-blood-pressure-in-six-us-cities
#13
Jennifer M Radin, Daniel Neems, Ross Goglia, Khan Siddiqui, Steven R Steinhubl
This study aims to evaluate the relationship between mean outdoor temperature and mean daily blood pressure (BP) and heart rate (HR) among six, large, geographically and climatically diverse US cities. We collected BP and HR data from Higi stations, located in a wide range of neighborhood grocery stores and retail pharmacies, from six US cities (Houston, Los Angeles, Miami, Boise, Chicago, and New York City). Outdoor daily temperature data were collected from the National Centers for Environmental Information's database...
April 19, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29676644/air-pollution-exposure-with-fine-dust-responses-in-the-pulmonary-vasculature-and-the-right-heart
#14
Nedim Durmus, Gabriele Grunig
Detrimental effects of air pollution with fine dust (particulate matter ≤2.5 μm in aerodynamic diameter, or PM2.5 ) on the systemic circulation and the left heart have been studied intensely during the past decade. In comparison, knowledge regarding the effects of exposure to air pollution with PM2.5 on the pulmonary vasculature and the right heart lags far behind. A report on severe lung disease and right heart failure in coal miners was published nearly 170 years ago. However, today, we still do not have a clear picture of how the effect of air pollution on the pulmonary circulation or the right heart should be viewed from a clinical, mechanistic biological, therapeutic, or economic angle...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676281/risk-thresholds-for-alcohol-consumption-combined-analysis-of-individual-participant-data-for-599-912-current-drinkers-in-83-prospective-studies
#15
Angela M Wood, Stephen Kaptoge, Adam S Butterworth, Peter Willeit, Samantha Warnakula, Thomas Bolton, Ellie Paige, Dirk S Paul, Michael Sweeting, Stephen Burgess, Steven Bell, William Astle, David Stevens, Albert Koulman, Randi M Selmer, W M Monique Verschuren, Shinichi Sato, Inger Njølstad, Mark Woodward, Veikko Salomaa, Børge G Nordestgaard, Bu B Yeap, Astrid Fletcher, Olle Melander, Lewis H Kuller, Beverley Balkau, Michael Marmot, Wolfgang Koenig, Edoardo Casiglia, Cyrus Cooper, Volker Arndt, Oscar H Franco, Patrik Wennberg, John Gallacher, Agustín Gómez de la Cámara, Henry Völzke, Christina C Dahm, Caroline E Dale, Manuela M Bergmann, Carlos J Crespo, Yvonne T van der Schouw, Rudolf Kaaks, Leon A Simons, Pagona Lagiou, Josje D Schoufour, Jolanda M A Boer, Timothy J Key, Beatriz Rodriguez, Conchi Moreno-Iribas, Karina W Davidson, James O Taylor, Carlotta Sacerdote, Robert B Wallace, J Ramon Quiros, Rosario Tumino, Dan G Blazer, Allan Linneberg, Makoto Daimon, Salvatore Panico, Barbara Howard, Guri Skeie, Timo Strandberg, Elisabete Weiderpass, Paul J Nietert, Bruce M Psaty, Daan Kromhout, Elena Salamanca-Fernandez, Stefan Kiechl, Harlan M Krumholz, Sara Grioni, Domenico Palli, José M Huerta, Jackie Price, Johan Sundström, Larraitz Arriola, Hisatomi Arima, Ruth C Travis, Demosthenes B Panagiotakos, Anna Karakatsani, Antonia Trichopoulou, Tilman Kühn, Diederick E Grobbee, Elizabeth Barrett-Connor, Natasja van Schoor, Heiner Boeing, Kim Overvad, Jussi Kauhanen, Nick Wareham, Claudia Langenberg, Nita Forouhi, Maria Wennberg, Jean-Pierre Després, Mary Cushman, Jackie A Cooper, Carlos J Rodriguez, Masaru Sakurai, Jonathan E Shaw, Matthew Knuiman, Trudy Voortman, Christa Meisinger, Anne Tjønneland, Hermann Brenner, Luigi Palmieri, Jean Dallongeville, Eric J Brunner, Gerd Assmann, Maurizio Trevisan, Richard F Gillum, Ian Ford, Naveed Sattar, Mariana Lazo, Simon G Thompson, Pietro Ferrari, David A Leon, George Davey Smith, Richard Peto, Rod Jackson, Emily Banks, Emanuele Di Angelantonio, John Danesh
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank)...
April 14, 2018: Lancet
https://www.readbyqxmd.com/read/29676178/afm-as-a-tool-to-evaluate-the-risk-for-cardiovascular-diseases-in-patients
#16
Ana Filipa Guedes, Luís Sargento, José Braz-Nogueira, Nuno Lousada, Carlos Moreira, Filomena A Carvalho, Nuno C Santos
Erythrocyte aggregation is an indicator of cardiovascular risk, which is influenced by plasma fibrinogen concentration. Fibrinogen levels are elevated during cardiovascular diseases. Our main goals were to understand how fibrinogen-erythrocyte binding influences erythrocyte aggregation and how it constitutes a cardiovascular risk factor in essential arterial hypertension (EAH) and chronic heart failure (CHF). Fibrinogen-erythrocyte and erythrocyte-erythrocyte adhesion measurements were conducted by atomic force microscopy (AFM)-based force spectroscopy...
2018: Annals of Medicine
https://www.readbyqxmd.com/read/29674324/indications-for-the-performance-of-intracranial-endovascular-neurointerventional-procedures-a-scientific-statement-from-the-american-heart-association
#17
REVIEW
Clifford J Eskey, Philip M Meyers, Thanh N Nguyen, Sameer A Ansari, Mahesh Jayaraman, Cameron G McDougall, J Kevin DeMarco, William A Gray, David C Hess, Randall T Higashida, Dilip K Pandey, Constantino Peña, Hermann C Schumacher
Intracranial endovascular interventions provide effective and minimally invasive treatment of a broad spectrum of diseases. This area of expertise has continued to gain both wider application and greater depth as new and better techniques are developed and as landmark clinical studies are performed to guide their use. Some of the greatest advances since the last American Heart Association scientific statement on this topic have been made in the treatment of ischemic stroke from large intracranial vessel occlusion, with more effective devices and large randomized clinical trials showing striking therapeutic benefit...
April 19, 2018: Circulation
https://www.readbyqxmd.com/read/29672754/comorbidity-clusters-in-people-with-gout-an-observational-cohort-study-with-linked-medical-record-review
#18
Megan Bevis, Milisa Blagojevic-Bucknall, Christian Mallen, Samantha Hider, Edward Roddy
Objective: To investigate how comorbid conditions cluster in patients with gout in a UK primary care population. Methods: A cross-sectional study was performed using baseline data from a primary-care-based prospective observational cohort of people aged ⩾18 years with gout. Participants with gout were identified through primary care medical records. Factor analysis was performed to obtain distinct clusters of comorbidity variables including obesity, hypertension, diabetes mellitus, hyperlipidaemia, coronary heart disease, heart failure, chronic kidney disease (CKD) and cancer...
April 17, 2018: Rheumatology
https://www.readbyqxmd.com/read/29672718/mineralocorticoid-receptor-antagonists-in-kidney-transplantation-time-to-consider
#19
Sophie Girerd, Frédéric Jaisser
Although patient survival is significantly improved by kidney transplantation (KT) in comparison with dialysis, it remains significantly lower than that observed in the general population. Graft function is one of the major determinants of patient survival after KT. Mineralocorticoid receptor antagonists (MRAs) could be of particular interest in this population to improve graft function and treat or prevent cardiovascular (CV) complications. In KT, ischaemia/reperfusion injury is a major factor involved in delayed graft function, which is often associated with inferior long-term graft survival...
April 17, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29670472/seasonal-incidence-of-acute-coronary-syndrome-and-its-features
#20
Enisa Hodzic, Semir Perla, Amer Iglica, Marina Vucijak
Introduction: Acute coronary syndrome (ACS) is one of the most common health problems in the world and the leading cause of death. Goal: The goals of this study are to determine: ACS type, risk factors, incidence and the seasonal distribution of occurrence Spring/Summer, Autumn/Winter, ACS incidence by age and gender, and complications (post-infarction angina and heart failure) and fatal outcomes of ACS per season. Material and methodology: This study is designed as retrospective-prospective and analytical, which included 250 patients hospitalized in the Intensive Cardiac care unit of the Clinic for heart disease, blood vessels and rheumatism in the period from June 2013 to July 2014...
March 2018: Materia Socio-medica
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