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https://www.readbyqxmd.com/read/29908131/low-body-mass-index-is-a-risk-factor-for-hyperkalaemia-associated-with-angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-treatments
#1
T Hirai, R Yamaga, A Fujita, T Itoh
WHAT IS KNOWN AND OBJECTIVE: Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) represent the cornerstones of hypertension and congestive heart failure treatment. Risk factors for hyperkalaemia associated with ACEI and ARB are chronic kidney disease and concomitant medications which increase serum potassium level. Body mass index (BMI) also affects pharmacokinetics of ACEI and ARB and potassium disposition. We evaluated the relationship between BMI and hyperkalaemia associated with ACEI and ARB treatments...
June 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29907132/association-between-multiple-comorbidities-and-self-rated-health-status-in-middle-aged-and-elderly-chinese-the-china-kadoorie-biobank-study
#2
Xingyue Song, Jing Wu, Canqing Yu, Wenhong Dong, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li
BACKGROUND: Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and global SRH and age-comparative SRH. METHODS: A total of 512,891 participants aged 30-79 years old were recruited into the China Kadoorie Biobank study from ten regions between 2004 and 2008. Multivariate logistic regression models were used to estimate the odds ratios (ORs) for the associations between comorbidities (including diabetes, hypertension, coronary heart disease, rheumatic heart disease, stroke, tuberculosis, emphysema/bronchitis, asthma, cirrhosis/chronic hepatitis, peptic ulcer, gallbladder disease, kidney disease, fracture, rheumatic arthritis, psychiatric disorders, depressive symptoms, neurasthenia, head injury and cancer) and SRH...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29906243/the-chemerin-knockout-rat-reveals-chemerin-dependence-in-female-but-not-male-experimental-hypertension
#3
Stephanie W Watts, Emma S Darios, Adam E Mullick, Hannah Garver, Thomas L Saunders, Elizabeth D Hughes, Wanda E Filipiak, Michael G Zeidler, Nichole McMullen, Christopher J Sinal, Ramya K Kumar, David J Ferland, Gregory D Fink
Measures of the adipokine chemerin are elevated in multiple cardiovascular diseases, including hypertension, but little mechanistic work has been done to implicate chemerin as being causative in such diseases. The chemerin knockout (KO) rat was created to test the hypothesis that removal of chemerin would reduce pressure in the normal and hypertensive state. Western analyses confirmed loss of chemerin in the plasma and tissues of the KO vs. wild-type (WT) rats. Chemerin concentration in plasma and tissues was lower in WT females than in WT males, as determined by Western analysis...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29906223/new-mouse-model-of-pulmonary-hypertension-induced-by-respiratory-syncytial-virus-bronchiolitis
#4
Dai Kimura, Jordy Saravia, Sridhar Jaligama, Isabella McNamara, Luan D Vu, Ryan D Sullivan, Salvatore Mancarella, Dahui You, Stephania A Cormier
Pulmonary hypertension (PH) has been observed in up to 75% of infants with moderate to severe respiratory syncytial virus (RSV) bronchiolitis and is associated with significant morbidity and mortality in infants with congenital heart disease. The purpose of this study was to establish a mouse model of PH secondary to RSV bronchiolitis that mimics the disease etiology as it occurs in infants. Neonatal mice were infected with RSV at 5 days of age, and then re-infected 4 weeks later. Serum free medium was administered to age-matched mice as control...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29906222/analysis-of-the-microrna-signature-driving-adaptive-right-ventricular-hypertrophy-in-an-ovine-model-of-congenital-heart-disease
#5
Rebecca Johnson Kameny, Youping He, Terry Zhu, Wenhui Gong, Gary W Raff, Cheryl J Chapin, Sanjeev A Datar, Jason Boehme, Akiko Hata, Jeffrey R Fineman
The right ventricular (RV) response to pulmonary arterial hypertension (PAH) is heterogeneous. Most patients have maladaptive changes with RV dilation and failure while some-especially patients with PAH secondary to congenital heart disease (CHD)-have an adaptive response with hypertrophy and preserved systolic function. Mechanisms for RV adaptation to PAH are unknown despite RV function being a primary determinant of mortality. In our CHD ovine model with fetally-implanted aortopulmonary shunt (shunt lambs), we previously demonstrated an adaptive physiologic RV response to increased afterload with hypertrophy...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29904483/pulmonary-venous-varix-associated-with-mitral-regurgitation-mimicking-a-mediastinal-mass-a-case-report-and-review-of-the-literature
#6
Dana AlNuaimi, Reem AlKetbi, Usama AlBastaki, Claude Pierre-Jerome, Ebrahim Ahmad Ebrahim
Pulmonary vein varix is an unusual cause of a mediastinal mass on a chest radiograph. It may be found as an isolated malformation or as a sequela of pulmonary venous hypertension. We encountered a case presenting with left hemiparesis and a past medical history of rheumatic heart disease. The chest radiograph revealed a well-defined mediastinal mass that turned out to be a hugely dilated pulmonary vein on contrast enhanced computed tomography of the chest. The computed tomography of the brain and upper abdomen revealed bilateral cerebral infarction and splenic infarction...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29901741/veterans-caregiving-for-others-caregiving-as-a-factor-in-the-health-of-america-s-military-veterans
#7
Natalie A Manley, Bret L Hicken, Randall W Rupper
Introduction: Caregiving has become an important world-wide concern due to the increasing number of people living to old age who need day to day functional support. Many caregivers report moderate to high levels of caregiver burden, which has been associated with increased morbidity and mortality for both the caregiver and care recipient. There are numerous research publications on people who are caregivers for military veterans. However, there is little information on military veterans who are themselves caregivers...
June 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29901624/predictors-and-prognosis-for-incident-in-hospital-heart-failure-in-patients-with-preserved-ejection-fraction-after-first-acute-myocardial-infarction-an-observational-study
#8
Mingzhu Xu, Lihua Yan, Jialiang Xu, Xiangjun Yang, Tingbo Jiang
Patients with acute myocardial infarction (AMI) complicated by heart failure with preserved ejection fraction (HFpEF) are likely to have more adverse cardiovascular events and higher mortality. The purpose of this study was to examine the predictors and outcomes in AMI patients complicated by HFpEF.We examined the demographics, clinical data, and clinical outcomes in 405 consecutive subjects who firstly presented with AMI after undergoing emergency percutaneous coronary intervention from January 2013 to June 2016...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901241/evaluation-of-all-african-clinical-practice-guidelines-for-hypertension-quality-and-opportunities-for-improvement
#9
Patrick Mbah Okwen, Irene Maweu, Karen Grimmer, Janine Margarita Dizon
RATIONALE, AIMS, AND OBJECTIVES: Good-quality clinical practice guidelines (CPGs) provide recommendations based on current best-evidence summaries. Hypertension is a prevalent noncommunicable disease in Africa, with disastrous sequelae (stroke, heart, and kidney disease). Its effective management relies on good quality, current, locally relevant evidence. This paper reports on an all African review of the guidance documents currently informing hypertension management. METHODS: Attempts were made to contact 62 African countries for formal guidance documents used nationally to inform diagnosis and management of hypertension...
June 14, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29901088/fasudil-preserves-lung-endothelial-function-and-reduces-pulmonary-vascular-remodeling-in-a-rat-model-of-end%C3%A2-stage-pulmonary-hypertension-with-left-heart-disease
#10
Rulin Zhuang, Jinfu Wu, Fang Lin, Lu Han, Xiaoting Liang, Qingshu Meng, Yuyu Jiang, Zhulin Wang, Aixue Yue, Yuying Gu, Huimin Fan, Xiaohui Zhou, Zhongmin Liu
Pulmonary hypertension (PH) due to left heart disease (LHD) is a common condition associated with significant morbidity. It contributes to the elevation of pulmonary vascular resistance and mean pulmonary pressure, eventually leading to heart failure and even mortality. The present study aimed to explore the potential efficacy of late and long‑term treatment with a Rho‑kinase (ROCK) signaling inhibitor, namely fasudil, in a rat model of end‑stage PH‑LHD. The PH‑LHD model was established by supracoronary aortic banding, and the effect of fasudil treatment on the progression of PH‑LHD was monitored...
June 13, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29900347/endothelial-microparticles-and-vascular-parameters-in-subjects-with-and-without-arterial-hypertension-and-coronary-artery-disease
#11
Roberto Sansone, Maximilian Baaken, Patrick Horn, Dominik Schuler, Ralf Westenfeld, Nicolas Amabile, Malte Kelm, Christian Heiss
Endothelial microparticles (EMPs) are markers of endothelial injury and activation. The role of EMPs in arterial hypertension is not well understood and EMPs are increased both in arterial hypertension and coronary artery disease (CAD). The data presented here show EMPs as defined by CD31+ /41- , CD62e+ , and CD144+ surface markers and vascular hemodynamic parameters including office and central blood pressure, heart rate, aortic augmentation index, pulse wave velocity, flow-mediated dilation, nitroglycerin-mediated dilation, brachial artery diameter, hyperemic wall shear stress, and laser Doppler perfusion of the cutaneous microcirculation of normotensives and hypertensives with and without CAD...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29899755/combination-therapy-in-the-treatment-of-hypertension
#12
REVIEW
Carolina Guerrero-García, Alberto Francisco Rubio-Guerra
Hypertension is a major preventable risk factor for atherosclerosis and ischemic heart disease. Although modern and effective antihypertensive drugs are available, most patients remain with a suboptimal blood pressure control. Most hypertensive patients will need a combination of antihypertensive agents to achieve the therapeutic goals - recent guidelines recommend initiating treatment with two drugs in those patients with a systolic blood pressure >20 mmHg and/or a diastolic blood pressure >10 mmHg above the goals, and in those patients with high cardiovascular risk...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29899376/prevalence-awareness-treatment-and-control-of-hypertension-in-the-malaysian-population-findings-from-the-national-health-and-morbidity-survey-2006-2015
#13
Nur Liana Ab Majid, Mohd Azahadi Omar, Yi Yi Khoo, Balkish Mahadir Naidu, Jane Ling Miaw Yn, Wan Shakira Rodzlan Hasani, Halizah Mat Rifin, Hamizatul Akmal Abd Hamid, Tania Gayle Robert Lourdes, Muhammad Fadhli Mohd Yusoff
Hypertension is strongly associated with chronic diseases such as myocardial infarction, stroke, heart failure, and renal failure. The objective of this study is to determine the trend of prevalence, awareness, treatment, and control of hypertension among Malaysian population since 2006 to 2015. The study used the data from National Health and Morbidity Survey (NHMS) 2006, 2011, and 2015. It was a cross-sectional with two-stage stratified random sampling throughout Malaysia for eligible respondents 18 years old and above...
June 13, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29898864/modern-treatment-to-reduce-pulmonary-arterial-pressure-in-pulmonary-arterial-hypertension
#14
REVIEW
Satoshi Akagi, Hiromi Matsubara, Kazufumi Nakamura, Hiroshi Ito
Treatment goals in pulmonary arterial hypertension (PAH) include improved quality of life and exercise capacity as well as improved life prognosis. In our experience, only remarkable reductions in pulmonary arterial pressure (PAP) improve long-term survival. Lowering PAP could contribute to reverse remodeling by reducing hemodynamic stress. Proper and prompt use of PAH-specific drugs lowers PAP in patients with PAH. Upfront combination therapy with different PAH-specific drugs and quickly establishing high-dose epoprostenol lowers PAP sufficiently to improve prognosis in patients with PAH...
June 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29897824/the-risk-of-cardiovascular-disease-end-stage-renal-disease-and-stroke-in-post-partum-women-and-their-fetuses-after-a-hypertensive-pregnancy
#15
Mark W Cunningham, Babbette D LaMarca
Women with hypertensive pregnancy complications are at greater risk of developing cardiovascular disease (CVD), metabolic diseases, stroke, and end-stage renal disease later in life. Pregnancy complications not only effect the mother's long-term health, but also the health of the fetus immediately after delivery and into adulthood. The health of the fetus until adulthood can be influenced by developmental programming, in which the fetus is exposed to insults that will ultimately affect the growth of the offspring and increase the offspring's risk of developing hypertension, coronary heart disease, metabolic disease, and chronic kidney disease in adulthood...
June 13, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29895976/an-essential-role-for-wnt-%C3%AE-catenin-signaling-in-mediating-hypertensive-heart-disease
#16
Yue Zhao, Chunhong Wang, Cong Wang, Xue Hong, Jinhua Miao, Yulin Liao, Lili Zhou, Youhua Liu
Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart disease. However, how RAS activation causes cardiac lesions remains elusive. Here we report the involvement of Wnt/β-catenin signaling in this process. In rats with chronic infusion of angiotensin II (Ang II), eight Wnt ligands were induced and β-catenin activated in both cardiomyocytes and cardiac fibroblasts. Blockade of Wnt/β-catenin signaling by small molecule inhibitor ICG-001 restrained Ang II-induced cardiac hypertrophy by normalizing heart size and inhibiting hypertrophic marker genes...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29895845/associations-of-social-and-economic-and-pregnancy-exposures-with-blood-pressure-in-uk-white-british-and-pakistani-children-age-4-5
#17
Jane West, Debbie A Lawlor, Gillian Santorelli, Paul Collings, Peter H Whincup, Naveed A Sattar, Diane Farrar, John Wright
South Asians have higher rates of coronary heart disease (CHD) than White European individuals. Blood pressure (BP) is one of the most important risk factors for CHD and ethnic differences in BP have been identified in childhood. Early life exposures could explain some of these differences. We examined associations of family social and economic and maternal pregnancy exposures and BP at age 4/5 in 1644 White British and 1824 Pakistani mother-offspring pairs from the Born in Bradford study. We found that systolic BP was similar but diastolic BP was higher, in Pakistani compared to White British children (adjusted mean differences were -0...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29895486/left-ventricular-assist-devices-in-pulmonary-hypertension-group-2-with-significantly-elevated-pulmonary-vascular-resistance-a-bridge-to-cure
#18
Ahmed M Selim, Lalit Wadhwani, Adam Burdorf, Eugenia Raichlin, Brian Lowes, Ronald Zolty
BACKGROUND: Pulmonary hypertension secondary to left heart disease (WHO Group 2) is a known risk factor in patients with heart failure. The favourable effect of left ventricular assist devices (LVAD) on pulmonary hypertension has been demonstrated before, although this effect has not been well-studied in advanced pulmonary arterial bed disease with a significant elevation in pulmonary vascular resistance. METHODS: We reviewed the records of 258 LVAD patients in our institution...
May 18, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29895484/coping-and-cardiac-troponin-t-a-risk-for-hypertension-and-sub-clinical-ecg-left-ventricular-hypertrophy-the-sabpa-study
#19
Catharina Elizabeth Myburgh, Leoné Malan, Annemarie Wentzel, Jacobus De Wet Scheepers, Nicolaas Theodor Malan
BACKGROUND: Defensive coping (DefS) was associated with cardiovascular disease (CVD) susceptibility in Blacks. Whether coping strategies will associate with sub-clinical left ventricular hypertrophy (electrocardiographic-left ventricular hypertrophy [ECG-LVH] or Cornell product), cardiomyocyte injury and blood pressure (BP), is unclear. Therefore, we assessed relationships between ECG-LVH, cardiac troponin T (cTnT) and 24-hour BP in bi-ethnic groups when habitually utilising a certain coping style, and these groups when having a stress-related cTnT cut-point of 4...
May 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29893359/correlation-between-sex-and-prognosis-of-acute-aortic-dissection-in-the-chinese-population
#20
Yan-Jie Liu, Xiao-Zeng Wang, Ya Wang, Rui-Xia He, Lin Yang, Quan-Min Jing, Hai-Wei Liu
Background: The prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex. Greater understanding on the differences between men and women with acute aortic dissection (AAD) is needed. We aimed to investigate whether sex disparities are found in patients with AAD, and to study sex differences in complications, mortality in-hospital, and long-term. Methods: We included 884 patients enrolled in our institute between June 2002 and May 2016...
June 20, 2018: Chinese Medical Journal
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