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https://www.readbyqxmd.com/read/29660063/five-successful-pregnancies-with-antenatal-anakinra-exposure
#1
Chelsey J F Smith, Christina D Chambers
Objectives: Our aim is to add to the limited existing prospective data on IL-1 inhibitor use in pregnancy. Methods: Data were obtained from the Organization of Teratology Information Specialists Autoimmune Disease in Pregnancy Project, a prospective cohort study of pregnancy outcomes in the USA and Canada. Eligible women were enrolled prior to 19 weeks' gestation between 2004 and 2017. Outcomes were obtained by maternal interview and medical record abstraction. Results: Five pregnancies with anakinra exposure were identified, all resulting in full-term singleton live births with no major or long-term complications...
April 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29660018/sexual-assault-and-disabling-ptsd-in-active-duty-service-women
#2
Denise Parnell, Vasudha Ram, Paulette Cazares, Jennifer Webb-Murphy, Melanie Roberson, Shiva Ghaed
Introduction: Sexual assault in the military is a major concern and may result in significant health problems, such as post-traumatic stress disorder (PTSD). Those developing disabling PTSD symptoms may require a disability evaluation. We examined disability evaluation trends for service women with PTSD to better understand characteristics associated with inability to continue Active Duty service. Methods: This is a retrospective review of disability reports and electronic medical records for 322 Active Duty women diagnosed with and treated for PTSD by psychiatrists and psychologists at a large military treatment facility between 2011 and 2014...
April 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29652176/medication-use-in-women-and-men-with-sudden-unexpected-death
#3
Sonalie Patel, Mitchell M Conover, Golsa Joodi, Sarah Chen, Ross J Simpson, Zachariah M Deyo
BACKGROUND: In Wake County, NC, sudden unexpected death accounts for 10% to 15% of all natural deaths in individuals 18 to 64 years old. Medications such as aspirin, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, and β-blockers are recommended in guidelines to reduce cardiovascular events and even sudden death (β-blockers). However, guidelines are often underpracticed, even in high-risk patients, with noted disparities in women. OBJECTIVE: We assessed the relation between prescription of evidence-based medications and sudden unexpected death in Wake County, NC...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29648909/diabetes-related-emergency-medical-service-activations-in-23-states-united-states-2015
#4
Stephen R Benoit, Henry S Kahn, Andrew I Geller, Daniel S Budnitz, N Clay Mann, Mengtao Dai, Edward W Gregg, Linda S Geiss
OBJECTIVE: The use of emergency medical services (EMS) for diabetes-related events is believed to be substantial but has not been quantified nationally despite the diverse acute complications associated with diabetes. We describe diabetes-related EMS activations in 2015 among people of all ages from 23 U.S. states. METHODS: We used data from 23 states that reported ≥95% of their EMS activations to the U.S. National Emergency Medical Services Information System (NEMSIS) in 2015...
April 12, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29644397/coq2-variants-in-parkinson-s-disease-and-multiple-system-atrophy
#5
Michitaka Mikasa, Kazuaki Kanai, Yuanzhe Li, Hiroyo Yoshino, Kaoru Mogushi, Arisa Hayashida, Aya Ikeda, Sumihiro Kawajiri, Yasuyuki Okuma, Kenichi Kashihara, Tatsuya Sato, Hiroshi Kondo, Manabu Funayama, Kenya Nishioka, Nobutaka Hattori
Coenzyme Q2, polyprenyltransferase (COQ2) variants have been reported to be associated with multiple system atrophy (MSA). However, the relationship between COQ2 variants and familial Parkinson's disease (PD) remains unclear. We investigated the frequency of COQ2 variants and clinical symptoms among familial PD and MSA. We screened COQ2 using the Sanger method in 123 patients with familial PD, 52 patients with sporadic PD, and 39 patients with clinically diagnosed MSA. Clinical information was collected from medical records for the patients with COQ2 variants...
April 11, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29643628/pediatric-critical-incidents-reported-over-15-years-at-a-tertiary-care-teaching-hospital-of-a-developing-country
#6
Shemila Abbasi, Fauzia Anis Khan, Sobia Khan
Background and Aims: The role of critical incident (CI) reporting is well established in improving patient safety but only a limited number of available reports relate to pediatric incidents. Our aim was to analyze the reported CIs specific to pediatric patients in our database and to reevaluate the value of this program in addressing issues in pediatric anesthesia practice. Material and Methods: Incidents related to pediatric population from neonatal period till the age of 12 years were selected...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29642905/high-use-of-private-providers-for-first-healthcare-seeking-by-drug-resistant-tuberculosis-patients-a-cross-sectional-study-in-yangon-myanmar
#7
Sucitro Dwijayana Sidharta, Jason Dean-Chen Yin, Joanne Su-Yin Yoong, Mishal Sameer Khan
BACKGROUND: Drug resistance is a growing challenge to tuberculosis (TB) control worldwide, but particularly salient to countries such as Myanmar, where the health system is fragmented across the public and private sector. A recent systematic review has identified a critical lack of evidence for local policymaking, particularly in relation to drivers of drug-resistance that could be the target of preventative efforts. To address this gap from a health systems perspective, our study investigates the healthcare-seeking behavior and preferences of recently diagnosed patients with drug-resistant tuberculosis (DR-TB), focusing on the use of private versus public healthcare providers...
April 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29629868/computed-tomography-identified-factors-that-preclude-living-kidney-donation
#8
Katerina Mastrocostas, Christina M Chingkoe, Kenneth T Pace, Joseph J Barfett, Anish Kirpalani, Gevork N Mnatzakanian, Paraskevi A Vlachou, Errol Colak
INTRODUCTION: The purpose of this study was to determine the variety and prevalence of renal and non-renal abnormalities detected on multi-detector computed tomography (MDCT) that precluded patients from donating a kidney. METHODS: Institutional review board approval was obtained and the requirement for informed consent was waived. A retrospective, single-centre review of 701 patients (444 female, 257 male; age range 18-86 years; mean age 43.2±11.9 years) that underwent renal donor protocol MDCT was conducted...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29628018/barriers-and-facilitators-affecting-the-implementation-of-substance-use-screening-in-primary-care-clinics-a-qualitative-study-of-patients-providers-and-staff
#9
Jennifer McNeely, Pritika C Kumar, Traci Rieckmann, Erica Sedlander, Sarah Farkas, Christine Chollak, Joseph L Kannry, Aida Vega, Eva A Waite, Lauren A Peccoralo, Richard N Rosenthal, Dennis McCarty, John Rotrosen
BACKGROUND: Alcohol and drug use are leading causes of morbidity and mortality that frequently go unidentified in medical settings. As part of a multi-phase study to implement electronic health record-integrated substance use screening in primary care clinics, we interviewed key clinical stakeholders to identify current substance use screening practices, barriers to screening, and recommendations for its implementation. METHODS: Focus groups and individual interviews were conducted with 67 stakeholders, including patients, primary care providers (faculty and resident physicians), nurses, and medical assistants, in two urban academic health systems...
April 9, 2018: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29627712/accurate-identification-of-opioid-overdose-deaths-using-coronial-data
#10
Amanda Roxburgh, Jennifer L Pilgrim, Wayne D Hall, Lucinda Burns, Louisa Degenhardt
INTRODUCTION: Defining drug-related mortality is complex as these deaths can include a wide range of diseases and circumstances. This paper outlines a method to identify deaths that are directly due to fatal opioid toxicity (i.e. overdose), utilising coronial data. MATERIALS AND METHODS: The National Coronial Information System (NCIS), an online coronial database containing information on all deaths that are reported to a coroner in Australia, is used to develop methods to more accurately identify opioid overdose deaths...
March 26, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29626591/impact-of-the-canadian-diabetes-association-guidelines-dissemination-strategy-on-clinician-knowledge-and-behaviour-change-outcomes
#11
Catherine H Yu, Erin Lillie, Alekhya Mascarenhas-Johnson, Carolyn Gall Casey, Sharon E Straus
AIM: Implementation of clinical practice guideline(CPG) into clinical practice remains limited. Using the Knowledge-To-Action framework, a guideline dissemination and implementation strategy for the Canadian Diabetes Association's 2013 CPG was developed and launched to clinicians and people with diabetes. METHODS: The RE-AIM framework guided evaluation of this strategy clinician; we report here one aspect of the effectiveness dimension using mixed methods. We measured impact of the strategy on clinican knowledge and behaviour change constructs using evaluation forms, national online survey and individual interviews...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29626348/clinical-outcomes-after-colopexy-through-left-ventral-paramedian-incision-in-156-thoroughbred-broodmares-with-large-colon-disorders-1999-2015
#12
Alecsya H Broyles, Scott A Hopper, J Brett Woodie, Alan J Ruggles
OBJECTIVE: To describe a technique for colopexy via a left ventral paramedian incision and report postoperative clinical outcomes. STUDY DESIGN: Retrospective case series. ANIMALS: One hundred fifty-six thoroughbred broodmares treated with a colopexy through a left ventral paramedian incision between 1999 and 2015. METHODS: Medical records were reviewed for postoperative complications and survival to discharge. The survival rate at 1 year after surgery was based on the medical record, progeny record, or client telephone conversation...
April 6, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29624676/validity-of-self-reported-periodontal-measures-demographic-characteristics-and-systemic-medical-conditions
#13
Georgios S Chatzopoulos, Alejandro Cisneros, Miguel Sanchez, Scott Lunos, Larry F Wolff
BACKGROUND: The objective of the present study was to assess self-reported periodontal screening questions, demographic characteristics, systemic medical conditions and tobacco use for predicting periodontal disease among individuals seeking dental therapy in a university dental clinic. METHODS: In this retrospective study, a total of 4,890 randomly selected dental charts were evaluated from among patients who had attended the University of Minnesota School of Dentistry clinics for treatment...
April 6, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29624099/use-of-electronic-health-records-to-characterize-a-rare-disease-in-the-usa-treatment-comorbidities-and-follow-up-trends-among-patients-with-a-confirmed-diagnosis-of-acromegaly
#14
Julie M Silverstein, Erin D Roe, Kashif M Munir, Janet L Fox, Birol Emir, Maria Kouznetsova, Lois E Lamerato, Donna King
Purpose Understanding of acromegaly disease management is hampered in the US by lack of a national registry. We describe medical management in a population with confirmed acromegaly. Methods Inpatient and outpatient Electronic Health Records (EHR) were used to create a database of de-identified patients assigned the Acromegaly and Gigantism ICD-9 code and/or an appropriate pituitary procedure code at one of four regional hospital systems over a 6-11 year period. Information regarding demographics, medical history, labs, procedures and medications was collected and supplemented with a chart review to validate the diagnosis of acromegaly...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29624088/intrastate-variation-in-treatment-and-outcomes-of-out-of-hospital-cardiac-arrest
#15
Ryan A Coute, Theresa A Shields, James A Cranford, Sardar Ansari, Mahshid Abir, M Hakam Tiba, Robert Dunne, Brian O'Neil, Robert Swor, Robert W Neumar
OBJECTIVE: Our objective was to analyze and compare out-of-hospital cardiac arrest (OHCA) system of care performance and outcomes at the Medical Control Authority (MCA) level in the state of Michigan. We hypothesized that clinically and statistically significant variations in treatment and outcomes of OHCA exists within a single U.S. state. METHODS: We performed a retrospective, observational study of all non-traumatic EMS-treated OHCA from the state of Michigan CARES registry for 2014-2015...
April 6, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29623142/chronic-pain-in-the-emergency-department-a-pilot-interdisciplinary-program-demonstrates-improvements-in-disability-psychosocial-function-and-healthcare-utilization
#16
Joshua A Rash, Patricia A Poulin, Yaadwinder Shergill, Heather Romanow, Jeffrey Freeman, Monica Taljaard, Guy Hebert, Ian G Stiell, Catherine E Smyth
Objective: To evaluate the feasibility of an individualized interdisciplinary chronic pain care plan as an intervention to reduce emergency department (ED) visits and improve clinical outcomes among patients who frequented the ED with concerns related to chronic pain. Methods: A prospective cohort design was used in an urban tertiary care hospital. As a pilot program, fourteen patients with chronic pain who frequented the ED (i.e., >12 ED visits within the last year, of which ≥50% were for chronic pain) received a rapid interdisciplinary assessment and individualized care plan that was uploaded to an electronic medical record system (EMR) accessible to the ED and patient's primary care provider...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29622982/cardiovascular-disease-and-abo-blood-groups-in-africans-are-blood-group-a-individuals-at-higher-risk-of-ischemic-disease-a-pilot-study
#17
Djibril Marie Ba, Mamadou Saidou Sow, Aminata Diack, Khadidiatou Dia, Mouhamed Cherif Mboup, Pape Diadie Fall, Moussa Daouda Fall
Background: Since the discovery of the ABO blood group system by Karl Landsteiner in 1901, several reports have suggested an important involvement of the ABO blood group system in the susceptibility to thrombosis. Assessing that non-O blood groups in particular A blood group confer a higher risk of venous and arterial thrombosis than group O.Epidemiologic data are typically not available for all racial and ethnics groups.The purpose of this pilot study was to identify a link between ABO blood group and ischemic disease (ID) in Africans, and to analyze whether A blood group individuals were at higher risk of ischemic disease or not...
December 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29622022/il-6-blockade-in-systemic-juvenile-idiopathic-arthritis-achievement-of-inactive-disease-and-remission-data-from-the-german-aid-registry
#18
M Bielak, E Husmann, N Weyandt, J-P Haas, B Hügle, G Horneff, U Neudorf, T Lutz, E Lilienthal, T Kallinich, K Tenbrock, R Berendes, T Niehues, H Wittkowski, E Weißbarth-Riedel, G Heubner, P Oommen, J Klotsche, Dirk Foell, E Lainka
BACKGROUND: Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed to proinflammatory cytokines like interleukin-6 (IL-6), and effective drugs inhibiting their signaling are being developed. This study evaluates sJIA patients treated with the IL-6 inhibitor tocilizumab (TCZ) concerning clinical response rate, disease course and adverse effects in a real-life clinical setting...
April 5, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29621836/a-systematic-review-of-coding-systems-used-in-pharmacoepidemiology-and-database-research
#19
Yong Chen, Marko Zivkovic, Tongtong Wang, Su Su, Jianyi Lee, Edward A Bortnichak
BACKGROUND: Clinical coding systems have been developed to translate real-world healthcare information such as prescriptions, diagnoses and procedures into standardized codes appropriate for use in large healthcare datasets. Due to the lack of information on coding system characteristics and insufficient uniformity in coding practices, there is a growing need for better understanding of coding systems and their use in pharmacoepidemiology and observational real world data research. OBJECTIVES: To determine: 1) the number of available coding systems and their characteristics, 2) which pharmacoepidemiology databases are they adopted in, 3) what outcomes and exposures can be identified from each coding system, and 4) how robust they are with respect to consistency and validity in pharmacoepidemiology and observational database studies...
February 2018: Methods of Information in Medicine
https://www.readbyqxmd.com/read/29621583/a-review-of-the-traditional-use-of-southern-african-medicinal-plants-for-the-treatment-of-selected-parasite-infections-affecting-humans
#20
REVIEW
I E Cock, M I Selesho, S F van Vuuren
ETHNOPHARMACOLOGICAL RELEVANCE: Worldwide, more than three billion cases of parasitic disease are reported yearly and it is likely that this figure is substantially under-estimated. Approximately one in six people globally are estimated to be infected with at least one parasite species annually. In South Africa, the prevalence of Schistosoma haematobium (bilharzia) and intestinal worms and helminths are particularly high, especially in children and in crowded or poorer rural communities with inadequate sanitation and nutritional status...
April 2, 2018: Journal of Ethnopharmacology
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