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https://www.readbyqxmd.com/read/29243255/viscoelastic-properties-of-human-aryepiglottic-fold-and-ventricular-fold-tissues-at-phonatory-frequencies
#1
Miwako Kimura, Roger W Chan
OBJECTIVE: The purpose of this study was to quantify the viscoelastic shear properties of the human ventricular fold (or false vocal fold) mucosa and aryepiglottic fold mucosa at frequencies of phonation. METHODS: Linear viscoelastic shear properties of the mucosa of false vocal fold and aryepiglottic fold specimens from seven cadaveric subjects were determined as functions of frequency (5-250 Hz) and compared to those of the true vocal fold cover. Measurements of elastic shear modulus (G') and dynamic viscosity (η') were made with a controlled-strain simple-shear rheometer...
December 15, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29243180/transoral-thyroidectomy-a-viable-surgical-option-with-unprecedented-complications-a-case-series
#2
S Bakkar, M Al Hyari, M Naghawi, C Corsini, P Miccoli
PURPOSE: To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS: From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the need to convert to cervicotomy, the length of hospital stay and post-operative pain and morbidity. Unconventional complications regarded as specific for TOETVA were reported...
December 14, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29242922/outcomes-following-cordotomy-by-coblation-for-bilateral-vocal-fold-immobility
#3
Michael S Benninger, Roy Xiao, Kyra Osborne, Paul C Bryson
Importance: Bilateral vocal fold immobility (BVFI) can result in considerable voice and airway impairment. Although the carbon dioxide (CO2) laser is commonly used in transverse cordotomy, the coblator, a minimally invasive, low-thermal technology, has been increasingly used in otolaryngology. Objective: To investigate outcomes associated with coblation to treat BVFI. Design, Setting, and Participants: A retrospective case series was conducted between January 2012 and June 2017 including 19 patients with BVFI who underwent cordotomy by coblation in a single tertiary care institution...
December 14, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29242052/endoscopic-and-phoniatric-evaluation-in-singing-students
#4
Andrea Nacci, Giovanna Baracca, Salvatore Osvaldo Romeo, Maria Denise Cavaliere, Maria Rosaria Barillari, Stefano Berrettini, Francesco Ursino, Bruno Fattori
OBJECTIVES: In To analyze laryngostroboscopic findings and ENT/phoniatric examination results in a group of singing students and in a control group of non-singing subjects to emphasize the importance of ENT/phoniatric examination and of laryngostroboscopy before taking up singing. METHODS: 56 singing students and 60 healthy euphonic non-singer volunteers were recruited. In each subject a perceptual assessment and a self-assessment (VHI) of the voice were performed...
December 11, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29242051/bamboo-nodes-on-a-series-of-15-patients-vocal-fold-lesion-as-a-sign-of-autoimmune-disease-and-microphonotrauma
#5
Natalie Oker, Aude Julien-Laferrière, Philippe Herman, Gérard Chevaillier
OBJECTIVES: Bamboo nodes are band-like submucosal deposits of the middle third of the vocal fold. They are often related to connective tissue disorders, but can also precede them. The aim of this study was to report our experience with conservative treatment of those rare lesions. METHODS: This is a retrospective series of 15 patients consulting for hoarseness and presenting bamboo nodes from 2010 to 2016. RESULTS: All patients were women of mean age of 38 years with a moderate or high degree of daily vocal effort...
December 11, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29241348/the-voice-of-autoimmunity-antisynthetase-syndrome-manifesting-as-vocal-fold-bamboo-nodes
#6
Matthew Kim, Babak Sadoughi
OBJECTIVES: To describe a case of vocal fold bamboo nodes leading to the diagnosis of antisynthetase syndrome, a rare autoimmune disorder. To highlight the link between these laryngeal lesions and autoimmunity. METHODS: A case of vocal fold bamboo nodes in a patient with long-standing interstitial lung disease is presented. The presence of these characteristic lesions prompted a rheumatologic workup that led to the diagnosis of a rare autoimmune disorder. RESULTS: The patient was ultimately diagnosed with antisynthetase syndrome, a rare condition characterized by inflammatory myositis and interstitial lung disease...
December 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29239810/pin-up-glottoplasty-feasibility-study-of-a-novel-approach-medializing-or-lateralizing-immobile-vocal-folds
#7
Christina Pflug, Almut Niessen, Frank Müller, Clarissa Precht, Julie C Nienstedt, Markus Hess
Principles in medializing and lateralizing vocal folds have not changed a lot within the last decades (Isshiki et al, 1974; Bruenings, 1911). We present a feasibility study for a completely new approach to perform medialization and lateralization of immobile vocal folds. The method was tested on 20 human larynges by inserting a 21G needle into the vocal fold, medializing (or, in other cases, lateralizing) the vocal cord and fixing the needle at the cricoid cartilage posteriorly. The anterior and posterior fixation points of the needle allow for a stable positioning of the needle, which we consider necessary in both cases of medialization or lateralization...
November 24, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29238989/nanoparticle-delivery-of-rna-based-therapeutics-to-alter-the-vocal-fold-tissue-response-to-injury
#8
Nao Hiwatashi, Iv Kraja, Peter A Benedict, Gregory R Dion, Renjie Bing, Bernard Rousseau, Milan R Amin, Danielle M Nalband, Kent Kirshenbaum, Ryan C Branski
OBJECTIVES/HYPOTHESIS: Our laboratory and others hypothesized that Smad3 is a principle mediator of the fibrotic phenotype in the vocal folds (VFs), and we further posited that alteration of Smad3 expression through short interfering (si)RNA holds therapeutic promise, yet delivery remains challenging. To address this issue, we employed a novel synthetic oligomer, lipitoid, complexed with siRNA to improve stability and cellular uptake with the goal of increased efficiency of RNA-based therapeutics...
December 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29236271/changes-in-abnormal-muscle-tension-pattern-after-fiberoptic-injection-laryngoplasty
#9
Georges Ziade, Ghassan Haddad, Sarah Assaad, Maher Kasti, Abdul-Latif Hamdan
We performed a retrospective chart review to compare the presence and types of abnormal muscle tension patterns (MTPs) in patients who had been diagnosed with glottal insufficiency before and after fiberoptic injection laryngoplasty. The main cause of glottal insufficiency had been unilateral vocal fold paralysis. Our review included an analysis of the medical records and laryngeal videostroboscopic recordings of 16 patients-9 men and 7 women, aged 25 to 87 years (mean: 59). Stroboscopic frames were analyzed for the presence of one or more types of abnormal MTP...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29235480/vocal-learning-promotes-patterned-inhibitory-connectivity
#10
Mark N Miller, Chung Yan J Cheung, Michael S Brainard
Skill learning is instantiated by changes to functional connectivity within premotor circuits, but whether the specificity of learning depends on structured changes to inhibitory circuitry remains unclear. We used slice electrophysiology to measure connectivity changes associated with song learning in the avian analog of primary motor cortex (robust nucleus of the arcopallium, RA) in Bengalese Finches. Before song learning, fast-spiking interneurons (FSIs) densely innervated glutamatergic projection neurons (PNs) with apparently random connectivity...
December 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29235013/effects-of-weight-loss-on-acoustic-parameters-after-bariatric-surgery
#11
Lourdes Bernadete Rocha de Souza, Marquiony Marques Dos Santos, Leandro Araújo Pernambuco, Cynthia Meira de Almeida Godoy, Deysianne Meire da Silva Lima
BACKGROUND: Patients with morbid obesity may present vocal alterations, since large accumulation of fat in the vocal tract may interfere with voice production of these individuals. OBJECTIVE: Verify the neck circumference and the acoustic parameters of voice in obese women, before and after the bariatric surgery, and compare the results with a control group, with normal weight. METHODS: Observational, longitudinal, descriptive study with patients referred to the SCODE (Obesity Surgery and Related Disorders Center) in a university hospital...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29231951/phonomicrosurgery-in-vocal-fold-nodules-quantification-of-outcomes-in-professional-and-non-professional-voice-users
#12
Philipp P Caffier, Tatjana Salmen, Tatiana Ermakova, Eleanor Forbes, Seo-Rin Ko, Wen Song, Manfred Gross, Tadeus Nawka
There are few data demonstrating the specific extent to which surgical intervention for vocal fold nodules (VFN) improves vocal function in professional (PVU) and non-professional voice users (NVU). The objective of this study was to compare and quantify results after phonomicrosurgery for VFN in these patient groups. METHODS: In a prospective clinical study, surgery was performed via microlaryngoscopy in 37 female patients with chronic VFN manifestations (38±12 yrs, mean±SD). Pre- and postoperative evaluations of treatment efficacy comprised videolaryngostroboscopy, auditory-perceptual voice assessment, voice range profile (VRP), acoustic-aerodynamic analysis, and voice handicap index (VHI-9i)...
December 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/29231041/using-trial-vocal-fold-injection-to-select-vocal-fold-scar-patients-who-may-benefit-from-more-durable-augmentation
#13
Thomas L Carroll, Aaron Dezube, Laura A Bauman, Pavan S Mallur
OBJECTIVES: Clinical indications for vocal fold injection augmentation (VFI) are expanding. Prior studies demonstrate the benefit of trial VFI for select causes of glottic insufficiency. No studies have examined trial VFI for glottic insufficiency resulting from true vocal fold (TVF) scar. METHODS: Retrospective chart review of patients who underwent trial VFI for a dominant pathology of TVF scar causing dysphonia. Patients who subsequently underwent durable augmentation were identified...
December 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29230589/physical-parameter-estimation-from-porcine-ex-vivo-vocal-fold-dynamics-in-an-inverse-problem-framework
#14
Pablo Gómez, Anne Schützenberger, Stefan Kniesburges, Christopher Bohr, Michael Döllinger
This study presents a framework for a direct comparison of experimental vocal fold dynamics data to a numerical two-mass-model (2MM) by solving the corresponding inverse problem of which parameters lead to similar model behavior. The introduced 2MM features improvements such as a variable stiffness and a modified collision force. A set of physiologically sensible degrees of freedom is presented, and three optimization algorithms are compared on synthetic vocal fold trajectories. Finally, a total of 288 high-speed video recordings of six excised porcine larynges were optimized to validate the proposed framework...
December 11, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29230133/invasive-insular-thyroid-carcinoma-presenting-as-nonparalytic-dysphonia
#15
Blake S Raggio, Blair M Barton, Maria C Grant, Judith A Fornadley, Jeffrey P Marino
Background: Patients with suspected thyroid malignancy often undergo preoperative laryngeal examination with a focus on vocal fold mobility. We present the unique case of a patient with invasive thyroid carcinoma who presented with dysphonia despite intact vocal fold motion. Case Report: A 73-year-old female with a remote thyroid lobectomy presented with dysphonia. Thyroid ultrasound and fine-needle aspiration revealed a 1.1-cm nodule consistent with a colloid cyst...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29224772/resolution-of-vocal-fold-immobility-in-preterm-infants
#16
Jad Jabbour, Thomas Robey
INTRODUCTION: Vocal fold immobility (VFI) is an important sequela of preterm birth due to patent ductus arteriosus (PDA) ligation and invasive ventilation. A minority of these patients experience VFI resolution. The purpose of this study is to determine factors associated with VFI resolution in preterm infants. METHODS: This is a case control study of preterm (<37 weeks gestation) infants admitted to a metropolitan Level IV neonatal intensive care unit from 2006 to 2012...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29219633/brain-activity-during-phonation-in-healthy-female-singers-with-supraglottic-compression-an-fmri-pilot-study
#17
Maryna Kryshtopava, Kristiane Van Lierde, Charlotte Defrancq, Michiel De Moor, Zoë Thijs, Evelien D'Haeseleer, Iris Meerschman, Pieter Vandemaele, Guy Vingerhoets, Sofie Claeys
This pilot study evaluated the usability of functional magnetic resonance imaging (fMRI) to detect brain activation during phonation in healthy female singers with supraglottic compression. Four healthy female classical singers (mean age: 26 years) participated in the study. All subjects had normal vocal folds and vocal characteristics and showed supraglottic compression. The fMRI experiment was carried out using a block design paradigm. Brain activation during phonation and exhalation was analyzed using Brain Voyager software (Brain Innovation B...
December 8, 2017: Logopedics, Phoniatrics, Vocology
https://www.readbyqxmd.com/read/29219188/toxicity-trial-of-canine-posterior-cricoarytenoid-intramuscular-vincristine-injections
#18
Randal C Paniello, Neel K Bhatt, Rebecca Chernock
OBJECTIVES/HYPOTHESIS: In animal studies, intramuscular vincristine injections have been shown to block reinnervation of the denervated target muscle. This application could be used selectively to influence recovery patterns following injury of recurrent laryngeal nerves (RLNs). However, vincristine is currently Food and Drug Administration approved only for intravenous use. A formal toxicity trial of intramuscular injections was performed. STUDY DESIGN: Animal study...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219186/improved-adductor-function-after-canine-recurrent-laryngeal-nerve-injury-and-repair-using-muscle-progenitor-cells
#19
Randal C Paniello, Sarah Brookes, Neel K Bhatt, Khadijeh Bijangi-Vishehsaraei, Hongji Zhang, Stacey Halum
OBJECTIVE: Muscle progenitor cells (MPCs) can be isolated from muscle samples and grown to a critical mass in culture. They have been shown to survive and integrate when implanted into rat laryngeal muscles. In this study, the ability of MPC implants to enhance adductor function of reinnervated thyroarytenoid muscles was tested in a canine model. STUDY DESIGN: Animal study. METHODS: Sternocleidomastoid muscle samples were harvested from three canines...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219184/minimal-clinically-important-difference-of-voice-handicap-index-10-in-vocal-fold-paralysis
#20
VyVy N Young, Kwonho Jeong, Scott D Rothenberger, Amanda I Gillespie, Libby J Smith, Jackie L Gartner-Schmidt, Clark A Rosen
OBJECTIVES/HYPOTHESIS: The Voice Handicap Index-10 (VHI-10) is commonly used to measure patients' perception of vocal handicap. Clinical consensus has previously defined clinically meaningful improvement as a decrease ≥5. This study determines the minimal clinically important difference (MCID) for VHI-10 in patients with unilateral vocal fold paralysis (UVFP) using anchor-based methodology. STUDY DESIGN: Prospective cohort questionnaire analysis. METHODS: Two hundred eighty-one UVFP patients completed the VHI-10 on two consecutive visits (within 3 months)...
December 8, 2017: Laryngoscope
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