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Root cause analysis

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https://www.readbyqxmd.com/read/29791686/extruded-upper-first-molar-intrusion-comparison-between-unilateral-and-bilateral-miniscrew-anchorage
#1
Mari Miura Sugii, Bruno de Castro Ferreira Barreto, Waldemir Francisco Vieira-Júnior, Katia Regina Izola Simone, Ataís Bacchi, Ricardo Armini Caldas
OBJECTIVE: The aim of his study was to evaluate the stress on tooth and alveolar bone caused by orthodontic intrusion forces in a supraerupted upper molar, by using a three-dimensional Finite Element Method (FEM). METHODS: A superior maxillary segment was modeled in the software SolidWorks 2010 (SolidWorks Corporation, Waltham, MA, USA) containing: cortical and cancellous bone, supraerupted first molar, periodontal tissue and orthodontic components. A finite element model has simulated intrusion forces of 4N onto a tooth, directed to different mini-screw locations...
January 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29791378/design-of-an-adjustable-bipod-flexure-for-a-large-aperture-mirror-of-a-space-camera
#2
Bei Liu, Wei Wang, Yan-Jun Qu, Xu-Peng Li, Xiao Wang, Hui Zhao
An adjustable bipod flexure (ABF) technique for a large-aperture mirror of a space camera is presented. The proposed flexure mount can decrease the surface distortions caused by the machining error and the assembly error of the mirror assembly (MA) in a horizontal optical testing layout. Through the analysis of the compliance matrix of conventional bipod flexure, the positional relationship between the rotation center and the apex of the flexure is investigated. Then, the principle of the adjustable flexure, known as the trapezoidal switching principle, is proposed based on the analysis result...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29790443/improvement-of-laboratory-turnaround-time-using-lean-methodology
#3
Shradha Gupta, Sahil Kapil, Monica Sharma
Purpose The purpose of this paper is to discuss the implementation of lean methodology to reduce the turnaround time (TAT) of a clinical laboratory in a super speciality hospital. Delays in report delivery lead to delayed diagnosis increased waiting time and decreased customer satisfaction. The reduction in TAT will lead to increased patient satisfaction, quality of care, employee satisfaction and ultimately the hospital's revenue. Design/methodology/approach The generic causes resulting in increasing TAT of clinical laboratories were identified using lean tools and techniques such as value stream mapping (VSM), Gemba, Pareto Analysis and Root Cause Analysis...
May 14, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29788153/aggregate-analysis-of-sentinel-events-as-a-strategic-tool-in-safety-management-can-contribute-to-the-improvement-of-healthcare-safety
#4
Angelo B Hooker, Anouk Etman, Matthijs Westra, Wouter J Van der Kam
Objective: To examine if clustering of root causes of sentinel events (SEs) can contribute to organisational improvement of healthcare and patient safety by providing insight into organisational risk factors, patterns and trends. Design: Retrospective, cross-sectional review of SEs from a hospital database reported to the Board of directors in 2016. Setting: A regional teaching hospital in the Netherlands. Intervention(s): Clustering of characteristics and variables of SEs to establish vulnerabilities and patterns of failure factors of the organisation...
May 19, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29783622/risk-mitigation-for-immunocompromised-consumers-of-mucormycete-spoiled-and-fermented-foods-germain-guidance-and-remaining-needs
#5
REVIEW
Abigail B Snyder, Randy W Worobo
Mucoralean invasive fungal infections, while unusual among the general population, have a high mortality rate among immunocompromised individuals who become infected. They are also common spoilage organisms in cultured dairy products, some fresh produce, and baked goods. Additionally, Mucor and Rhizopus spp. are utilized in the production of traditional fermented foods including mold ripened cheeses and fermented soy products. The risk that consumption of these foods poses to immunocompromised consumers has been previously identified...
May 18, 2018: Microorganisms
https://www.readbyqxmd.com/read/29782601/patient-centered-medical-home-status-and-preparedness-to-assess-resident-milestones-a-cera-study
#6
Thad Wilkins, Wonsuk Yoo, Ralph A Gillies, Julie Dahl-Smith, Jacqueline Dubose, Joseph Hobbs, Selina Smith, Dean A Seehusen
Purpose: The patient-centered medical home (PCMH) model has been proposed as the ideal model for delivering primary care and is focused on improving patient safety and quality, reducing costs, and enhancing patient satisfaction. The mandated Accreditation Council for Graduate Medical Education educational milestones for evaluation of resident competency represent the skills graduates will utilize after graduation. Many of these skills are reflected in the PCMH model. We sought to determine if residency programs whose main family medicine (FM) practice sites have achieved PCMH recognition are therefore more prepared to evaluate milestones...
May 2018: PRiMER: peer-review reports in medical education research
https://www.readbyqxmd.com/read/29777592/early-identification-of-unusually-clustered-mutations-and-a-root-cause-in-therapeutic-antibody-development
#7
Yueming Qian, Zhiqiang Chen, Xin Huang, Xuning Wang, Xuankuo Xu, Stefan Kirov, Richard Ludwig, Nan-Xin Qian, Kandasamy Ravi, Li Tao, Michael C Borys, Zheng Jian Li
This study reports findings of an unusual cluster of mutations spanning 22 base pairs in a monoclonal antibody (mAb) expression vector. It was identified by two orthogonal methods: mass spectrometry on expressed protein and next-generation sequencing (NGS) on the plasmid DNA. While the initial NGS analysis confirmed the designed sequence modification, intact mass analysis detected an additional mass of the antibody molecule expressed in CHO cells. The extra mass was eventually found to be associated with unmatched nucleotides in a distal region by checking full-length sequence alignment plots...
May 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29775864/exogenous-hydrogen-peroxide-inhibits-primary-root-gravitropism-by-regulating-auxin-distribution-during-arabidopsis-seed-germination
#8
Lina Zhou, Hongzhou Hou, Tao Yang, Yuke Lian, Yan Sun, Zhiyuan Bian, Chongying Wang
Hydrogen peroxide (H2 O2 ) is the key factor in many physiological and metabolic processes in plants. During seed germination, exogenous H2 O2 application influences gravitropism and induces curvature of the primary root in grass pea and pea seedlings. However, it remains unclear whether and how this happens in the model plant Arabidopsis thaliana. In the present study, the effect of exogenous H2 O2 on the gravitropic response of primary roots during Arabidopsis seed germination was studied using histology and molecular biology approaches...
May 15, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29775096/silicon-alleviates-arsenic-induced-toxicity-in-wheat-through-vacuolar-sequestration-and-ros-scavenging
#9
Md Monayem Hossain, Most Amena Khatun, Md Najmul Haque, Md Azizul Bari, Md Firoz Alam, Abul Mandal, Ahmad Humayan Kabir
Arsenic (As) is a phytotoxic element causing health hazards. This work investigates whether and how silicon (Si) alleviates As toxicity in wheat. The addition of Si under As-stress significantly improved morphophysiological characteristics, total protein, and membrane stability compared to As-stressed plants, suggesting that Si does have critical roles in As detoxification in wheat. Analysis of arsenate reductase activity and phytosiderophore (PS) release reveals their no involvement in the Si-mediated alleviation of As in wheat...
July 3, 2018: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29772492/high-copper-content-in-vineyard-soils-promotes-modifications-in-photosynthetic-parameters-and-morphological-changes-in-the-root-system-of-red-niagara-plantlets
#10
Vítor Gabriel Ambrosini, Daniel José Rosa, George Wellington Bastos de Melo, Jovani Zalamena, Cesar Cella, Daniela Guimarães Simão, Leandro Souza da Silva, Henrique Pessoa Dos Santos, Moreno Toselli, Tadeu Luis Tiecher, Gustavo Brunetto
High copper (Cu) soil contents, due to the continuous vineyard application of Cu fungicides throughout the years, may impair the growth of the shoot and modify the structure of the root system. The current study aimed to investigate the threshold levels of available Cu in the soil causing toxicity effects in young grapevine plants of 'Red Niagara' cultivated in clay soils. Grapevine plantlets were cultivated in pots containing vineyard devoted soils with increasing contents of available Cu (25, 80, 100 and 165 mg kg-1 ), for 53 days...
May 8, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29771294/the-maize-lilliputian1-lil1-gene-encoding-a-brassinosteroid-cytochrome-p450-c-6-oxidase-is-involved-in-plant-growth-and-drought-response
#11
Giulia Castorina, Martina Persico, Massimo Zilio, Stefano Sangiorgio, Laura Carabelli, Gabriella Consonni
Background and Aims: Brassinosteroids (BRs) are plant hormones involved in many developmental processes as well as in plant-environment interactions. Their role was investigated in this study through the analysis of lilliputian1-1 (lil1-1), a dwarf mutant impaired in BR biosynthesis in maize (Zea mays). Methods: We isolated lil1-1 through transposon tagging in maize. The action of lil1 was investigated through morphological and genetic analysis. Moreover, by comparing lil1-1 mutant and wild-type individuals grown under drought stress, the effect of BR reduction on the response to drought stress was examined...
May 16, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29768578/-work-accidents-and-automatic-circuit-reclosers-in-the-electricity-sector-beyond-the-immediate-causes
#12
Alessandro Jose Nunes da Silva, Ildeberto Muniz de Almeida, Rodolfo Andrade de Gouveia Vilela, Renata Wey Berti Mendes, Sandra Lorena Beltran Hurtado
The Brazilian electricity sector has recorded high work-related mortality rates that have been associated with outsourcing, used to cut costs. In order to decrease the power outage time for consumers, the industry adopted the automatic circuit recloser as the technical solution. The device has hazardous implications for maintenance workers. The aim of this study was to analyze the origins and consequences of work accidents in power systems with automatic circuit recloser, using the Accident Analysis and Prevention (AAP) model...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29762887/the-underreporting-of-medication-errors-a-retrospective-and-comparative-root-cause-analysis-in-an-acute-mental-health-unit-over-a-3-year-period
#13
Maeve Morrison, Vicki Cope, Melanie Murray
Medication errors remain a commonly reported clinical incident in health care as highlighted by the World Health Organization's focus to reduce medication-related harm. This retrospective quantitative analysis examined medication errors reported by staff using an electronic Clinical Incident Management System (CIMS) during a 3-year period from April 2014 to April 2017 at a metropolitan mental health ward in Western Australia. The aim of the project was to identify types of medication errors and the context in which they occur and to consider recourse so that medication errors can be reduced...
May 15, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29762546/transcriptome-analysis-in-chinese-cabbage-brassica-rapa-ssp-pekinensis-provides-the-role-of-glucosinolate-metabolism-in-response-to-drought-stress
#14
Seung Hee Eom, Seung-A Baek, Jae Kwang Kim, Tae Kyung Hyun
Although drought stress is one of the most limiting factors in growth and production of Chinese cabbage ( Brassica rapa L. ssp. pekinensis), the underlying biochemical and molecular causes are poorly understood. In the present study, to address the mechanisms underlying the drought responses, we analyzed the transcriptome profile of Chinese cabbage grown under drought conditions. Drought stress transcriptionally activated several transcription factor genes, including AP2 / ERFs , bHLHs , NACs and bZIPs , and was found to possibly result in transcriptional variation in genes involved in organic substance metabolic processes...
May 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29761290/isolation-and-functional-characterization-of-a-floral-repressor-bcflc2-from-pak-choi-brassica-rapa-ssp-chinensis
#15
Feiyi Huang, Tongkun Liu, Jin Wang, Xilin Hou
BcFLC2 functioned as a repressor of flowering by directly regulating BcTEM1, BcMAF2, BcSOC1 and BcSPL15 in Pak-choi. FLOWERING LOCUS C (FLC) plays an important role in regulating flowering time. Here, we functionally described an FLC homologous gene, BcFLC2, that negatively regulated flowering in Pak-choi (Brassica rapa ssp. chinensis). The sequence comparison to Arabidopsis FLC showed that BcFLC2 also had a MADS-box domain at the N terminus. BcFLC2 was highly expressed in the leaves, roots, stems and stamens, and its expression was repressed by vernalization in Pak-choi...
May 14, 2018: Planta
https://www.readbyqxmd.com/read/29758950/simulated-medication-errors-a-means-of-evaluating-healthcare-professionals-knowledge-and-understanding-of-medication-safety
#16
Hesty Utami Ramadaniati, Jeffery David Hughes, Ya Ping Lee, Lynne Maree Emmerton
OBJECTIVE: To determine multi-disciplinary perceptions of the clinical significance of medication errors (MEs), the responsible health professional(s), the contributing factors and potential preventive strategies. METHODS: The five simulated ME cases represented errors from five wards at a children's hospital in Australia. Pre-determined answers for each case were developed through consensus among the researchers. The root cause analysis (RCA) was undertaken via a questionnaire disseminated to physicians, nurses and pharmacists at the study hospital to seek their opinions on the ME cases...
May 9, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29756070/reducing-severe-hypoglycaemia-in-hospitalised-patients-with-diabetes-early-outcomes-of-standardised-reporting-and-management
#17
Katherine A Araque, Deepak K Kadayakkara, Nino Gigauri, Diane Sheehan, Sachin Majumdar, Gregory Buller, Clare A Flannery
Background: Severe hypoglycaemic events (HGEs) in hospitalised patients are associated with poor outcomes and prolonged hospitalization. Systematic, coordinated care is required for acute management and prevention of HGEs; however, studies evaluating quality control efforts are scarce. Objective: To investigate the effectiveness of system-based interventions to improve management response to HGEs. Methods: System-based interventions were designed and implemented following a root cause analysis of HGE in adult patients with diabetes from two general medical wards with the highest incidence of HGE...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29755366/normal-values-of-corrected-heart-rate-variability-in-10-second-electrocardiograms-for-all-ages
#18
Marten E van den Berg, Peter R Rijnbeek, Maartje N Niemeijer, Albert Hofman, Gerard van Herpen, Michiel L Bots, Hans Hillege, Cees A Swenne, Mark Eijgelsheim, Bruno H Stricker, Jan A Kors
Purpose: Heart-rate variability (HRV) measured on standard 10-s electrocardiograms (ECGs) has been associated with increased risk of cardiac and all-cause mortality, but age- and sex-dependent normal values have not been established. Since heart rate strongly affects HRV, its effect should be taken into account. We determined a comprehensive set of normal values of heart-rate corrected HRV derived from 10-s ECGs for both children and adults, covering both sexes. Methods: Five population studies in the Netherlands (Pediatric Normal ECG Study, Leiden University Einthoven Science Project, Prevention of Renal and Vascular End-stage Disease Study, Utrecht Health Project, Rotterdam Study) provided 10-s, 12-lead ECGs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29751225/effects-of-cadmium-and-copper-mixtures-to-carrot-and-pakchoi-under-greenhouse-cultivation-condition
#19
Shengnan Hou, Na Zheng, Lin Tang, Xiaofeng Ji
A pot experiment was undertaken to investigate the effects of Cd and Cu mixtures to growth and nutrients (sugar, carotene or vitamin C) of carrot and pakchoi under greenhouse cultivation condition. The study included: (a) physical-chemical properties of soil and soil animals in response to Cd and Cu stress; (b) bioaccumulation of heavy metals, length, biomass, contents of sugar and carotene (vitamin C) of carrot and pakchoi; (c) estimation the effects of Cd and Cu mixtures by multivariate regression analysis...
May 8, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29750808/potential-use-of-high-throughput-sequencing-of-soil-microbial-communities-for-estimating-the-adverse-effects-of-continuous-cropping-on-ramie-boehmeria-nivea-l-gaud
#20
Siyuan Zhu, Yanzhou Wang, Xiaomin Xu, Touming Liu, Duanqing Wu, Xia Zheng, Shouwei Tang, Qiuzhong Dai
Ramie (Boehmeria nivea L. Gaud) fiber, one of the most important natural fibers, is extracted from stem bark. Continuous cropping is the main obstacle to ramie stem growth and a major cause of reduced yields. Root-associated microbes play crucial roles in plant growth and health. In this study, we investigated differences between microbial communities in the soil of healthy and continuously cropped ramie plants, and sought to identify potential mechanisms whereby these communities could counteract the problems posed by continuous cropping...
2018: PloS One
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