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https://www.readbyqxmd.com/read/28936201/trichoderma-asperelloides-spores-downregulate-dectin1-2-and-tlr2-receptors-of-mice-macrophages-and-decrease-candida-parapsilosis-phagocytosis-independent-of-the-m1-m2-polarization
#1
Andréa G Dos Santos, Érica A Mendes, Rafael P de Oliveira, Ana M C Faria, Aurizangela O de Sousa, Carlos P Pirovani, Fernanda F de Araújo, Andréa T de Carvalho, Marliete Carvalho Costa, Daniel Assis Santos, Quimi V Montoya, Andre Rodrigues, Jane L Dos Santos
The intensive use of pesticides to control pests in agriculture has promoted several issues relating to environment. As chemical pesticides remain controversial, biocontrol agents originating from fungi could be an alternative. Among them, we highlight biocontrol agents derived from the fungi genus Trichoderma, which have been documented in limiting the growth of other phytopathogenic fungus in the roots and leaves of several plant species. An important member of this genus is Trichoderma asperelloides, whose biocontrol agents have been used to promote plant growth while also treating soil diseases caused by microorganisms in both greenhouses and outdoor crops...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28936179/seasonal-variations-in-heart-rate-variability-as-an-indicator-of-stress-in-free-ranging-pregnant-przewalski-s-horses-e-ferus-przewalskii-within-the-hortob%C3%A3-gy-national-park-in-hungary
#2
Friederike Pohlin, Kristin Brabender, Gerhard Fluch, Gabrielle Stalder, Thierry Petit, Chris Walzer
Background: Ecosystems with seasonal fluctuations in climate and food availability present physiological challenges to resident mammals and may cause "stress." The two predominant physiological responses to stressors are (1) the activation of the hypothalamic-pituitary-adrenal axis and (2) the modulation of the autonomic nervous system. To date, the primary indicator for "stress" in wildlife- and zoo animal research are glucocorticoid levels. By measuring the autonomic regulation of cardiac activity, particularly the vagal tone, heart rate variability (HRV) is presently emerging as a suitable indicator of "stress" in farm- and domestic animal research...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28934361/restriction-modification-mediated-barriers-to-exogenous-dna-uptake-and-incorporation-employed-by-prevotella-intermedia
#3
Christopher D Johnston, Chelsey A Skeete, Alexey Fomenkov, Richard J Roberts, Susan R Rittling
Prevotella intermedia, a major periodontal pathogen, is increasingly implicated in human respiratory tract and cystic fibrosis lung infections. Nevertheless, the specific mechanisms employed by this pathogen remain only partially characterized and poorly understood, largely due to its total lack of genetic accessibility. Here, using Single Molecule, Real-Time (SMRT) genome and methylome sequencing, bisulfite sequencing, in addition to cloning and restriction analysis, we define the specific genetic barriers to exogenous DNA present in two of the most widespread laboratory strains, P...
2017: PloS One
https://www.readbyqxmd.com/read/28933087/-in-vitro-screening-and-identification-of-plant-growth-promoting-rhizobacteria-against-pathogen-causing-astragalus-root-rot
#4
Fen Gao, Rui Hao, Xue-Mei Qin, Zhen-Hong Lei, Yu-Long Wang, Meng-Liang Wang
The antagonistic effect of Bacillus spp. against Fusarium solani was evaluated by living body dual culture and Oxford cup method. The plant growth promoting properties of those strains that had obvious and stable antifungal activity were then tested. The results showed that the living body and bacteria-free fermentation filtrate of strain G10 both had obvious and stable antifungal effect to F. solani. Besides, the strain possessed such growth promoting properties as phosphate solubilization, nitrogen fixation, and production of IAA, amylase and HCN...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28932242/analysis-of-the-chemical-modification-of-dental-enamel-submitted-to-35-hydrogen-peroxide-in-office-whitening-with-or-without-calcium
#5
Rudá França Moreira, Fábio Pinheiro Santos, Estevão Antero Santos, Ramon Silva Dos Santos, Marcelino José Dos Anjos, Mauro Sayão de Miranda
PURPOSE: The purpose of this study was to evaluate changes in calcium and phosphorus content in dental enamel when subjected to "in-office" whitening for an extended time by using a 35% hydrogen peroxide solution, with and without calcium. MATERIALS AND METHODS: 10 human teeth, from which the roots had been removed, were embedded in epoxy resin, and their surfaces were smoothed. The specimens were divided into two groups; in group 1, a whitening solution without calcium was used, while in group 2, the solution included calcium...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28931574/enhanced-nociception-in-angelman-syndrome-model-mice
#6
Eric S McCoy, Bonnie Taylor-Blake, Megumi Aita, Jeremy M Simon, Benjamin D Philpot, Mark J Zylka
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutation or deletion of the maternal UBE3A allele. The maternal UBE3A allele is expressed in nearly all neurons of the brain and spinal cord, whereas the paternal UBE3A allele is repressed by an extremely long antisense transcript (UBE3A-ATS). Little is known about expression of UBE3A in the peripheral nervous system, where loss of maternal UBE3A might contribute to AS phenotypes. Here we sought to examine maternal and paternal Ube3a expression in dorsal root ganglia (DRG) neurons and to evaluate whether nociceptive responses were affected in AS model mice (global deletion of maternal Ube3a allele; Ube3a(m-/p+) )...
September 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28928390/fast-and-slow-transient-charging-of-oxide-semiconductor-transistors
#7
Taeho Kim, Sungho Park, Sanghun Jeon
The comprehension of the governing mechanism which affects device instability is one of the most important requirements for the formation of reliable oxide-thin film transistors (TFTs). However, a quantitative analysis of the dominant mechanism of device instability, which stems from charge trapping induced by defects at the oxide semiconductor interface as well as in its bulk, has not yet been systematically performed. In this study, we examined subgap states, charge-transport dynamics, and various trap characteristics of oxide TFTs by multi-frequency C-V, pulse I-V, and transient current methods to achieve a comprehensive understanding of carrier transport and charge trapping mechanisms...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28925588/evaluation-of-the-effect-of-four-final-irrigation-protocols-on-root-canal-dentin-components-by-polarized-light-microscopy-and-scanning-electron-microscopy
#8
Flávia Emi Razera Baldasso, Luana Roleto Cardoso, Vinicius Duval da Silva, Renata Dornelles Morgental, Patrícia Maria Poli Kopper
The present study aimed to evaluate the effects of four endodontic chelating agents, followed by 2.5% sodium hypochlorite (NaOCl), as final irrigation regimens on organic and inorganic components of human root dentin. Sixty mandibular incisors were prepared and randomly divided into six groups (n = 10): QMiX, 1% peracetic acid (PA), 17% EDTA, 10% citric acid (CA), 2.5% NaOCl (solution control) and distilled water (DW-negative control). After irrigation with the chelating agents, a final flush was performed with 2...
September 19, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28923507/pentagalloylglucose-a-highly-bioavailable-polyphenolic-compound-present-in-cortex-moutan-efficiently-blocks-hepatitis-c-virus-entry
#9
Patrick Behrendt, Paula Perin, Nicolas Menzel, Dominic Banda, Stephanie Pfaender, Marco P Alves, Volker Thiel, Phillip Meulemann, Che C Colpitts, Luis M Schang, Florian W R Vondran, Anggakusuma, Michael P Manns, Eike Steinmann, Thomas Pietschmann
Approximately 142 million people worldwide are infected with hepatitis C virus (HCV). Although potent direct acting antivirals are available, high costs limit access to treatment. Chronic hepatitis C virus infection remains a major cause of orthotopic liver transplantation. Moreover, re-infection of the graft occurs regularly. Antivirals derived from natural sources might be an alternative and cost-effective option to complement therapy regimens for global control of hepatitis C virus infection. We tested the antiviral properties of a mixture of different Chinese herbs/roots named Zhi Bai Di Huang Wan (ZBDHW) and its individual components on HCV...
September 15, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28920167/comparison-of-efficacy-between-dorsal-root-entry-zone-lesioning-and-selective-dorsal-rhizotomy-for-spasticity-of-cerebral-origin
#10
Bunpot Sitthinamsuwan, Luckchai Phonwijit, Inthira Khampalikit, Akkapong Nitising, Sarun Nunta-Aree, Sirilak Suksompong
BACKGROUND: Severe spasticity adversely affects patient functional status and caregiving. No previous study has compared efficacy between dorsal root entry zone lesioning (DREZL) and selective dorsal rhizotomy (SDR) for reduction of spasticity. This study aimed to investigate the efficacy of DREZL and SDR for attenuating spasticity, and to compare efficacy between these two methods. METHODS: All patients who underwent DREZL, SDR, or both for treatment of intractable spasticity caused by cerebral pathology at Siriraj Hospital during 2009 to 2016 were recruited...
September 17, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28919931/improving-hierarchical-models-using-historical-data-with-applications-in-high-throughput-genomics-data-analysis
#11
Ben Li, Yunxiao Li, Zhaohui S Qin
Modern high-throughput biotechnologies such as microarray and next generation sequencing produce a massive amount of information for each sample assayed. However, in a typical high-throughput experiment, only limited amount of data are observed for each individual feature, thus the classical 'large p, small n' problem. Bayesian hierarchical model, capable of borrowing strength across features within the same dataset, has been recognized as an effective tool in analyzing such data. However, the shrinkage effect, the most prominent feature of hierarchical features, can lead to undesirable over-correction for some features...
June 2017: Statistics in Biosciences
https://www.readbyqxmd.com/read/28914227/a-system-analysis-of-delay-in-outpatient-respiratory-equipment-delivery
#12
Sheila Kun, Gregory Placencia, Sally Davidson Ward, Thomas Keens
OBJECTIVES: To systematically assess barriers delaying home respiratory equipment requisition and to evaluate for temporal correlation between delays and emergency room or hospitalization episodes. BACKGROUND: Initiation of home respiratory treatments is delayed because of delays in delivery of durable medical equipment (DME). This study assesses root causes of such delays from a system perspective. We also describe clinical consequences by measuring emergency room visits and hospitalization days for temporal correlations...
December 1, 2016: Care Management Journals: Journal of Case Management ; the Journal of Long Term Home Health Care
https://www.readbyqxmd.com/read/28913575/day-to-day-fasting-glycaemic-variability-in-devote-associations-with-severe-hypoglycaemia-and-cardiovascular-outcomes-devote-2
#13
Bernard Zinman, Steven P Marso, Neil R Poulter, Scott S Emerson, Thomas R Pieber, Richard E Pratley, Martin Lange, Kirstine Brown-Frandsen, Alan Moses, Ann Marie Ocampo Francisco, Jesper Barner Lekdorf, Kajsa Kvist, John B Buse
AIMS/HYPOTHESIS: The Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE) was a double-blind, randomised, event-driven, treat-to-target prospective trial comparing the cardiovascular safety of insulin degludec with that of insulin glargine U100 (100 units/ml) in patients with type 2 diabetes at high risk of cardiovascular events. This paper reports a secondary analysis investigating associations of day-to-day fasting glycaemic variability (pre-breakfast self-measured blood glucose [SMBG]) with severe hypoglycaemia and cardiovascular outcomes...
September 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28912786/co-infection-of-sweet-orange-with-severe-and-mild-strains-of-citrus-tristeza-virus-is-overwhelmingly-dominated-by-the-severe-strain-on-both-the-transcriptional-and-biological-levels
#14
Shimin Fu, Jonathan Shao, Changyong Zhou, John S Hartung
Citrus tristeza is one of the most destructive citrus diseases and is caused by the phloem-restricted Closterovirus, Citrus tristeza virus. Mild strain CTV-B2 does not cause obvious symptoms on indicators whereas severe strain CTV-B6 causes symptoms, including stem pitting, cupping, yellowing, and stiffening of leaves, and vein corking. Our laboratory has previously characterized changes in transcription in sweet orange separately infected with CTV-B2 and CTV-B6. In the present study, transcriptome analysis of Citrus sinensis in response to double infection by CTV-B2 and CTV-B6 was carried out...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28910339/genome-wide-association-mapping-of-resistance-to-phytophthora-sojae-in-a-soybean-glycine-max-l-merr-germplasm-panel-from-maturity-groups-iv-and-v
#15
Jun Qin, Qijian Song, Ainong Shi, Song Li, Mengchen Zhang, Bo Zhang
Phytophthora sojae, an oomycete pathogen of soybean, causes stem and root rot, resulting in annual economic loss up to $2 billion worldwide. Varieties with P. sojae resistance are environmental friendly to effectively reduce disease damages. In order to improve the resistance of P. sojae and broaden the genetic diversity in Southern soybean cultivars and germplasm in the U.S., we established a P. sojae resistance gene pool that has high genetic diversity, and explored genomic regions underlying the host resistance to P...
2017: PloS One
https://www.readbyqxmd.com/read/28901625/systemic-challenges-in-bipolar-disorder-management-a-patient-centered-approach
#16
Anastasiya Nestsiarovich, Nathaniel G Hurwitz, Stuart J Nelson, Annette S Crisanti, Berit Kerner, Matt J Kuntz, Alicia N Smith, Emma Volesky, Quentin L Schroeter, Jason L DeShaw, S Stanley Young, Robert L Obenchain, Ronald L Krall, Kimmie Jordan, Jan Fawcett, Mauricio Tohen, Douglas J Perkins, Christophe G Lambert
OBJECTIVES: As part of a series of Patient-Centered Outcomes Research Institute-funded large-scale retrospective observational studies on bipolar disorder (BD) treatments and outcomes, we sought the input of patients with BD and their family members to develop research questions. We aimed to identify systemic root causes of patient-reported challenges with BD management in order to guide subsequent studies and initiatives. METHODS: Three focus groups were conducted where patients and their family members (total n = 34) formulated questions around the central theme, "What do you wish you had known in advance or over the course of treatment for BD?" In an affinity mapping exercise, participants clustered their questions and ranked the resulting categories by importance...
September 13, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28900770/how-regularities-of-mortality-statistics-explain-why-we-age-despite-having-potentially-ageless-somatic-stem-cells
#17
Alexander V Khalyavkin, Vyacheslav N Krut'ko
Researchers working in the area of ageing have found numerous manifestations of this process at the molecular biological level, including DNA and protein damage, accumulation of metabolic by-products, lipids peroxidation, macromolecular cross-linking, non-enzymatic glycosylation, anti-oxidant/pro-oxidant misbalance, rising of pro-inflammatory cytokines, etc. This results in an increase in the proportion of cells in growth arrest, reduction of the rate of information processing, metabolic rate decrease, and decrease in rates of other processes characterizing dynamic aspects of the organism's interaction with its environment...
September 12, 2017: Biogerontology
https://www.readbyqxmd.com/read/28899444/use-of-implementation-science-for-a-sustained-reduction-of-central-line-associated-bloodstream-infections-in-a-high-volume-regional-burn-unit
#18
Geeta Sood, Julie Caffrey, Kelly Krout, Zeina Khouri-Stevens, Kevin Gerold, Stefan Riedel, Janet McIntyre, Lisa L Maragakis, Renee Blanding, Jonathan Zenilman, Richard Bennett, Peter Pronovost
OBJECTIVE We describe the use of implementation science at the unit level and organizational level to guide an intervention to reduce central-line-associated bloodstream infections (CLABSIs) in a high-volume, regional, burn intensive care unit (BICU). DESIGN A single center observational quasi-experimental study. SETTING A regional BICU in Maryland serving 300-400 burn patients annually. INTERVENTIONS In 2011, an organizational-level and unit-level intervention was implemented to reduce the rates of CLABSI in a high-risk patient population in the BICU...
September 13, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28895282/a-patient-safety-education-program-in-a-medical-physics-residency
#19
Eric C Ford, Matthew Nyflot, Matthew B Spraker, Gabrielle Kane, Kristi R G Hendrickson
Education in patient safety and quality of care is a requirement for radiation oncology residency programs according to accrediting agencies. However, recent surveys indicate that most programs lack a formal program to support this learning. The aim of this report was to address this gap and share experiences with a structured educational program on quality and safety designed specifically for medical physics therapy residencies. Five key topic areas were identified, drawn from published recommendations on safety and quality...
September 12, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28894554/exploring-the-adaptive-experiences-of-children-with-parents-of-myocardial-infarction-a-qualitative-study
#20
Tahere Hashemifard, Ali Akbar Vaezi, Seyed Saeed Mazloomy, Tahere Kamalikhah, Mehdi Khankolabi, Abbas Andishmand, Mohammad Hossein Baghianimoghadam
BACKGROUND: Cardiovascular diseases are the world's leading cause of mortality. These diseases are rooted in an unhealthy lifestyle. In order to confront this subject, it is essential to identify several risk factors that contribute to heart disease (HD) in people with different attitudes, values, beliefs, expectations and motivations. This study was therefore an attempt to explain the adaptive experiences of children whose parents were involved in myocardial infarction since they were more likely subjected to get the so-called disease...
July 2017: Electronic Physician
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