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Root cause analysis

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https://www.readbyqxmd.com/read/29163405/overexpression-of-the-prunus-sogdiana-nbs-lrr-subgroup-gene-psorpm2-promotes-resistance-to-the-root-knot-nematode-meloidogyne-incognita-in-tobacco
#1
Xiang Zhu, Kun Xiao, Haiyang Cui, Jianfang Hu
Root-knot nematodes (RKNs), particularly Meloidogyne incognita, are the most devastating soil-borne pathogens that significantly affect the production of Prunus spp. fruit. RKN infection is difficult to control and consequently causes massive yield losses each year. However, several germplasms of wild Prunus spp. have been shown to display resistance to M. incognita. Consequently, both the isolation of novel plant resistance (R) genes and the characterization of their resistance mechanisms are important strategies for future disease control...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29158708/medication-safety-officer-preparatory-course-outcomes-and-experiences
#2
Hisham Aljadhey, Salma Alkhani, Tahir Mehmood Khan
Purpose: Few hospitals employ a medication safety officer. A medication safety officer preparatory course was planned using a structured curriculum to prepare pharmacists with the knowledge and skills to start medication safety officer activities. The current study aims to assess the outcome, as change in knowledge, of a hospital medication safety officer preparatory course. Methods: We conducted a three-day course in February 2011 in Riyadh, Saudi Arabia. It was developed to provide attendees with the essential knowledge and skills to become a medication safety officer...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29155538/aetiological-histopathological-clinical-diagnostic-and-therapeutical-features-of-idiopathic-cervical-resorption
#3
Virginia Robles Gijón, Cristina Lucena Martín, Rosa Mª Pulgar Encinas, José Manuel Navajas
Root resorption is the loss of hard dental tissue as a result of odontoclastic action involving vital and pulpless teeth. Cervical root resorption (CRR) is a type of external resorption which usually occurs immediately below the epithelial attachment of the tooth in the cervical region. The idiopathic cervical resorption (ICR) refers to a clinical situation in which all other causes, whether local or systemic, have been ruled out as the origin of the disease. The early stage is asymptomatic and might be diagnosed by a routine radiograph or a clinical examination...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29154611/individual-and-systemic-barriers-to-health-care-perspectives-of-lesbian-gay-bisexual-and-transgender-adults
#4
Meghan Romanelli, Kimberly D Hudson
Access to effective services is imperative to address the many health and mental health disparities that lesbian, gay, bisexual, and transgender (LGBT) people face. This population, however, remains underserved and often ill-served in health care environments. Furthermore, interactions between system- and individual-level dimensions of access create barriers to service engagement. Within much of the extant literature surrounding health care barriers among LGBT people, the rich narratives and varied experiences of LGBT community members from diverse backgrounds have often been excluded...
2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/29153016/whole-root-transcriptomic-analysis-suggests-a-role-for-auxin-pathways-in-resistance-to-ralstonia-solanacearum-in-tomato
#5
Elizabeth French, Bong-Suk Kim, Katherine Rivera-Zuluaga, Anjali Iyer-Pascuzzi
The soilborne pathogen Ralstonia solanacearum is the causal agent of bacterial wilt, and causes significant crop loss in the Solanaceae family. The pathogen first infects roots, which are a critical source of resistance in tomato (Solanum lycopersicum L.). Roots of both resistant and susceptible plants are colonized by the pathogen, yet rootstocks can provide significant levels of resistance. Currently, mechanisms of this 'root-mediated resistance' remain largely unknown. To identify the molecular basis of this resistance, we analyzed the genome-wide transcriptional response of roots of resistant (Hawaii 7996) and susceptible (West Virginia700) tomatoes at multiple time points after inoculation with R...
November 20, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29148978/antidiabetic-and-in-vitro-antioxidant-effects-of-hydromethanol-extract-of-paullinia-pinnata-root-bark-in-alloxan-induced-diabetic-rat
#6
Onoja Samuel Okwudili, Nwachukwu Glory Chimaobi, Ezeja Maxwell Ikechukwu, Omeh Yusuf Ndukaku
Background The study evaluated phytochemical composition, antidiabetic, oral glucose tolerance test and in vitro antioxidant activities of hydromethanol extract of Paullinia pinnata root bark. Methods Cold maceration method was used in extract preparation and scavenging of 2,2-diphenyl-1-picrylhydrazyl radicals was used to evaluate antioxidant properties of the extract. Diabetes was induced with alloxan at the dose of 160 mg/kg. The antidiabetic activity of the extract was tested at doses of 50, 100 and 200 mg/kg, and glibenclamide was used as reference drug...
November 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29148138/artificial-walking-technologies-to-improve-gait-in-cerebral-palsy-multichannel-neuromuscular-stimulation
#7
Jessica Rose, Katelyn Cahill-Rowley, Erin E Butler
Cerebral palsy (CP) is the most common childhood motor disability and often results in debilitating walking abnormalities, such as flexed-knee and stiff-knee gait. Current medical and surgical treatments are only partially effective in improving gait abnormalities and may cause significant muscle weakness. However, emerging artificial walking technologies, such as step-initiated, multichannel neuromuscular electrical stimulation (NMES), can substantially improve gait patterns and promote muscle strength in children with spastic CP...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29147988/phytoextraction-with-salix-viminalis-in-a-moderately-to-strongly-contaminated-area
#8
Dávid Tőzsér, Sándor Harangi, Edina Baranyai, Gyula Lakatos, Zoltán Fülöp, Béla Tóthmérész, Edina Simon
We tested the suitability of Salix viminalis for phytoextraction with the analysis of selected elements in soil, root, and leaf, and by visual tree condition assessment in an area with varying levels of contamination. Bioconcentration factor (BCF) and translocation factor (TF) were used to assess the phytoextraction potential of willows. The middle part of the study area was strongly contaminated, while the northern and southern parts were moderately contaminated. We found increasing element concentrations toward deeper layers...
November 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29145871/challenges-to-implementing-gavi-s-health-system-strengthening-support-in-chad-and-cameroon-results-from-a-mixed-methods-evaluation
#9
Emily Dansereau, Yodé Miangotar, Ellen Squires, Honoré Mimche, Charbel El Bcheraoui
BACKGROUND: Since 2005, Gavi has provided health system strengthening (HSS) grants to address bottlenecks affecting immunization services. This study is the first to evaluate the Gavi HSS implementation process in either Cameroon or Chad, two countries with significant health system challenges and poor achievement on the child and maternal health Millennium Development Goals. METHODS: We triangulated quantitative and qualitative data including financial records, document review, field visit questionnaires, and key informant interviews (KII) with representatives from the Ministries of Health, Gavi, and other partners...
November 16, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29142437/docking-based-screening-of-ficus-religiosa-phytochemicals-as-inhibitors-of-human-histamine-h2-receptor
#10
Amit Chaudhary, Birendra Singh Yadav, Swati Singh, Pramod Kumar Maurya, Alok Mishra, Shweta Srivastva, Pritish Kumar Varadwaj, Nand Kumar Singh, Ashutosh Mani
Background: Ficus religiosa L. is generally known as Peepal and belongs to family Moraceae. The tree is a source of many compounds having high medicinal value. In gastrointestinal tract, histamine H2 receptors have key role in histamine-stimulated gastric acid secretion. Their over stimulation causes its excessive production which is responsible for gastric ulcer. Objective: This study aims to screen the range of phytochemicals present in F. religiosa for binding with human histamine H2 and identify therapeutics for a gastric ulcer from the plant...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29139179/involvement-of-lemrp-an-atp-binding-cassette-transporter-in-shikonin-transport-and-biosynthesis-in-lithospermum-erythrorhizon
#11
Yu Zhu, Shu-Juan Chu, Yue-Lin Luo, Jiang-Yan Fu, Cheng-Yi Tang, Gui-Hua Lu, Yan-Jun Pang, Xiao-Ming Wang, Rong-Wu Yang, Jin-Liang Qi, Yong-Hua Yang
·Shikonin and its derivatives are important medicinal secondary metabolites accumulating in the roots of Lithospermum erythrorhizon. Although some membrane proteins have been identified as transporters of secondary metabolites, the mechanisms underlying shikonin transport and accumulation in L. erythrorhizon cells still remain largely unknown. ·In this study, we isolated a cDNA encoding LeMRP, an ATP-binding cassette transporter from L. erythrorhizon and further investigated its functions in the transport and biosynthesis of shikonin with the yeast transformation and transgenic hairy root method, respectively...
November 15, 2017: Plant Biology
https://www.readbyqxmd.com/read/29135450/influence-of-acquisition-frame-rate-and-video-compression-techniques-on-pulse-rate-variability-estimation-from-vppg-signal
#12
Luca Cerina, Luca Iozzia, Luca Mainardi
In this paper, common time- and frequency-domain variability indexes obtained by pulse rate variability (PRV) series extracted from video-photoplethysmographic signal (vPPG) were compared with heart rate variability (HRV) parameters calculated from synchronized ECG signals. The dual focus of this study was to analyze the effect of different video acquisition frame-rates starting from 60 frames-per-second (fps) down to 7.5 fps and different video compression techniques using both lossless and lossy codecs on PRV parameters estimation...
November 14, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29126990/a-proanthocyanidin-rich-extract-from-cassia-abbreviata-exhibits-antioxidant-and-hepatoprotective-activities-in-vivo
#13
Mansour Sobeh, Mona F Mahmoud, Mohamed A O Abdelfattah, Haroan Cheng, Assem M El-Shazly, Michael Wink
ETHNOPHARMACOLOGICAL RELEVANCE: Cassia abbreviata is a small to medium sized branched umbrella-shaped deciduous tree. It is widely spread in the tropics, especially in Africa, having a long history in traditional medicine for the treatment of numerous conditions such as headaches, diarrhea, constipation, some skin diseases, malaria, syphilis, pneumonia, stomach troubles, uterine pains, and against gonorrhea. AIM OF THE STUDY: We investigated the phytochemical constituents of a root extract from Cassia abbreviata using HPLC-PDA-ESI-MS/MS...
November 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29126605/a-novel-patterned-magnetic-micropillar-array-substrate-for-analysis-of-cellular-mechanical-responses
#14
Kazuaki Nagayama, Takuya Inoue, Yasuhiro Hamada, Takeo Matsumoto
Traction forces generated at cellular focal adhesions (FAs) play an essential role in regulating various cellular functions. These forces (1-100 nN) can be measured by observing the local displacement of a flexible substrate upon which cells have been plated. Approaches employing this method include using microfabricated arrays of poly(dimethylsiloxane) (PDMS) micropillars that bend by cellular traction forces. A tool capable of applying a force to FAs independently, by actively moving the micropillars, should become a powerful tool to delineate the cellular mechanotransduction mechanisms...
October 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29124042/e-fischeriana-root-compound-dpo-activates-antiviral-innate-immunity
#15
Jingxuan Chen, Hongqiang Du, Shuang Cui, Tong Liu, Guang Yang, Huaping Sun, Weiwei Tao, Baoping Jiang, Li Yu, Fuping You
E. fischeriana has long been used as a traditional Chinese medicine. Recent studies reported that some compounds of E. fischeriana exhibited antimicrobial and immune enhance activity. Innate immune system is essential for the immune surveillance of inner and outer threats, initial host defense responses and immune modulation. The role of natural drug compounds, including E. fischeriana, in innate immune regulation is largely unknown. Here we demonstrated that E. fischeriana compound Dpo is involved in antiviral signaling...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29121004/country-immunization-information-system-assessments-kenya-2015-and-ghana-2016
#16
Colleen Scott, Kristie E N Clarke, Jan Grevendonk, Samantha B Dolan, Hussein Osman Ahmed, Peter Kamau, Peter Aswani Ademba, Lynda Osadebe, George Bonsu, Joseph Opare, Stanley Diamenu, Gregory Amenuvegbe, Pamela Quaye, Fred Osei-Sarpong, Francis Abotsi, Joseph Dwomor Ankrah, Adam MacNeil
The collection, analysis, and use of data to measure and improve immunization program performance are priorities for the World Health Organization (WHO), global partners, and national immunization programs (NIPs). High quality data are essential for evidence-based decision-making to support successful NIPs. Consistent recording and reporting practices, optimal access to and use of health information systems, and rigorous interpretation and use of data for decision-making are characteristics of high-quality immunization information systems...
November 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29117917/antagonistic-endophytic-bacteria-associated-with-nodules-of-soybean-glycine-max-l-and-plant-growth-promoting-properties
#17
LongFei Zhao, YaJun Xu, XinHe Lai
A total of 276 endophytic bacteria were isolated from the root nodules of soybean (Glycine max L.) grown in 14 sites in Henan Province, China. The inhibitory activity of these bacteria against pathogenic fungus Phytophthora sojae 01 was screened in vitro. Six strains with more than 63% inhibitory activities were further characterized through optical epifluorescence microscopic observation, sequencing, and phylogenetic analysis of 16S rRNA gene, potential plant growth-promoting properties analysis, and plant inoculation assay...
October 13, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29116954/impact-of-an-original-methodological-tool-on-the-identification-of-corrective-and-preventive-actions-after-root-cause-analysis-of-adverse-events-in-health-care-facilities-results-of-a-randomized-controlled-trial
#18
Anthony Vacher, Sana El Mhamdi, Alain dʼHollander, Marion Izotte, Yves Auroy, Philippe Michel, Jean-Luc Quenon
OBJECTIVE: The aim of the study was to assess the effectiveness of a new methodological tool for the identification of corrective and preventive actions (CAPAs) after root cause analysis of health care-related adverse events. METHODS: From January to June 2010, we conducted a randomized controlled trial involving risk managers from 111 health care facilities of the Aquitaine Regional Center for Quality and Safety in Health Care (France). Fifty-six risk managers, randomly assigned to two groups (intervention and control), identified CAPAs in response to two sequentially presented adverse event scenarios...
November 8, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/29115926/co-expression-network-analysis-of-the-transcriptomes-of-rice-roots-exposed-to-various-cadmium-stresses-reveals-universal-cadmium-responsive-genes
#19
Mingpu Tan, Dan Cheng, Yuening Yang, Guoqiang Zhang, Mengjie Qin, Jun Chen, Yahua Chen, Mingyi Jiang
BACKGROUND: The migration of cadmium (Cd) from contaminated soil to rice is a cause for concern. However, the molecular mechanism underlying the response of rice roots to various Cd stresses remains to be clarified from the viewpoint of the co-expression network at a system-wide scale. RESULTS: We employed a comparative RNAseq-based approach to identify early Cd-responsive differentially expressed genes (DEGs) in rice 'Nipponbare' seedling roots after 1 h of high-Cd treatment...
November 7, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29114868/the-politics-of-social-status-economic-and-cultural-roots-of-the-populist-right
#20
Noam Gidron, Peter A Hall
This paper explores the factors that have recently increased support for candidates and causes of the populist right across the developed democracies, especially among a core group of working-class men. In the context of debates about whether the key causal factors are economic or cultural, we contend that an effective analysis must rest on understanding how economic and cultural developments interact to generate support for populism. We suggest that one way to do so is to see status anxiety as a proximate factor inducing support for populism, and economic and cultural developments as factors that combine to precipitate such anxiety...
November 2017: British Journal of Sociology
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