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Root cause analysis

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https://www.readbyqxmd.com/read/28437546/root-cause-analysis-and-actions-for-the-prevention-of-medical-errors-quality-improvement-and-resident-education
#1
Ryan Charles, Brandon Hood, Joseph M DeRosier, John W Gosbee, James P Bagian, Ying Li, Michelle S Caird, J Sybil Biermann, Mark E Hake
The quality of care delivered by orthopedic surgeons continues to grow in importance. Multiple orthopedic programs, organizations, and committees have been created to measure the quality of surgical care and reduce the incidence of medical adverse events. Structured root cause analysis and actions (RCA2) has become an area of interest. If performed thoroughly, RCA2 has been shown to reduce surgical errors across many subspecialties. The Accreditation Council for Graduate Medical Education has a new mandate for programs to involve residents in quality improvement processes...
April 24, 2017: Orthopedics
https://www.readbyqxmd.com/read/28435686/apple-dwarfing-rootstocks-exhibit-an-imbalance-in-carbohydrate-allocation-and-reduced-cell-growth-and-metabolism
#2
Toshi M Foster, Peter A McAtee, Chethi N Waite, Helen L Boldingh, Tony K McGhie
Apple dwarfing rootstocks cause earlier shoot termination and reduced root and shoot mass. To identify physiological factors responsible for rootstock-induced growth restriction, we compared vascular-enriched gene expression between two dwarfing rootstocks ('M27' and 'M9') and the vigorous rootstock 'M793' using RNA sequencing and quantitative reverse transcriptase PCR. Differentially expressed genes common to both dwarfing rootstocks belonged to five main biological processes: (1) primary metabolism, (2) cell wall synthesis and modification, (3) secondary metabolism, (4) hormone signalling and response and (5) redox homeostasis...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28434685/influence-of-inhomogeneous-dental-posts-on-stress-distribution-in-tooth-root-and-interfaces-three-dimensional-finite-element-analysis
#3
Mojtaba Mahmoudi, Ali Reza Saidi, Parviz Amini, Maryam Alsadat Hashemipour
STATEMENT OF PROBLEM: In post-core crown restorations, the use of flexible posts concentrates stresses at the dentin and the use of stiff posts concentrates stresses at the interfaces. A class of inhomogeneous materials (called functionally graded materials) has been proposed for posts to resolve the weaknesses of both flexible and rigid posts. PURPOSE: The purpose of this in vitro study was to design an inhomogeneous post and investigate its influence on the stress distribution of post-core crown restorations...
April 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28431271/investigation-of-pathology-malpractice-claims-in-china-from-2002-2015
#4
Yuan Li, Dong Gao, Meng Tu, Ying-Zhen Luo, Zhen-Hua Deng
OBJECTIVE: To examine pathology-related medical claims in China and identify the most common errors to result in such claims. METHOD: A retrospective analysis was performed of 71 forensic evaluation reports carried out in two Chinese institutes of forensic medicine between 2002 and 2015 due to suspicion of medical malpractice. The judicial outcomes of each case were also reviewed when available. RESULTS: Of 71 cases, 54 cases had judicial outcomes...
April 15, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28424966/transcriptomic-analysis-of-molecular-responses-in-malus-domestica-m26-roots-affected-by-apple-replant-disease
#5
Stefan Weiß, Melanie Bartsch, Traud Winkelmann
Gene expression studies in roots of apple replant disease affected plants suggested defense reactions towards biotic stress to occur which did not lead to adequate responses to the biotic stressors. Apple replant disease (ARD) leads to growth inhibition and fruit yield reduction in replanted populations and results in economic losses for tree nurseries and fruit producers. The etiology is not well understood on a molecular level and causal agents show a great diversity indicating that no definitive cause, which applies to the majority of cases, has been found out yet...
April 19, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28424716/growth-stimulatory-effects-and-genome-wide-transcriptional-changes-produced-by-protein-hydrolysates-in-maize-seedlings
#6
Chiara Santi, Anita Zamboni, Zeno Varanini, Tiziana Pandolfini
Protein hydrolysates are an emerging class of crop management products utilized for improving nutrient assimilation and mitigating crop stress. They generally consist of a mixture of peptides and free amino acids derived from the hydrolysis of plant or animal sources. The present work was aimed at studying the effects and the action mechanisms of a protein hydrolysate derived from animal residues on maize root growth and physiology in comparison with the effects induced by either free amino acids or inorganic N supply...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28423855/ehr-improvement-using-incident-reports
#7
Tesfay Teame, Tor Stålhane, Øystein Nytrø
This paper discusses reactive improvement of clinical software using methods for incident analysis. We used the "Five Whys" method because we had only descriptive data and depended on a domain expert for the analysis. The analysis showed that there are two major root causes for EHR software failure, and that they are related to human and organizational errors. A main identified improvement is allocating more resources to system maintenance and user training.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423803/business-rules-to-improve-secondary-data-use-of-electronic-healthcare-systems
#8
Jonathan Blaisure, Werner Ceusters
The 'fit for purpose' paradigm used for data quality assessment in electronic healthcare record (EHR) systems is not so fit when assessed in the light of secondary data use. An analysis of the difficulties encountered in trying to use existing EHR data for cohort identification for prospective clinical trials and retrograde data analytics, revealed the root causes to fall in three categories: (1) issues in workflow and data registration, (2) preventable inadequacies in software configuration and personalization and (3) software development issues on the side of the vendor...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28417888/general-concepts-of-patient-safety-for-the-oral-and-maxillofacial-surgeon
#9
REVIEW
David W Todd
Whether managing patients in private offices or as part of a care team at hospitals, oral and maxillofacial surgeons owe it to patients to understand medical error and take action to reduce its frequency and adverse effects. This article reviews general concepts of patient safety, including high-reliability organization, crew resource management, simulation training, root cause analysis, and just culture.
May 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28412605/brachytic-1-of-barley-hordeum-vulgare-l-encodes-the-%C3%AE-subunit-of-heterotrimeric-g-protein
#10
Ai Ito, Ayumi Yasuda, Kosuke Yamaoka, Minase Ueda, Akira Nakayama, Suguru Takatsuto, Ichiro Honda
Physiological and molecular biological analysis of the dwarf barley (Hordeum vulgare L.) mutant brachytic 1 (brh1) was conducted. The root responses of brh1 to brassinolide were weaker than those of wild type, but the responses of leaf segments of dark-grown plants were not. Responses of brh1 to gibberellin A3 were similar to or slightly stronger than those of wild type. Endogenous levels of these hormones in young seedlings were not clearly different between brh1 and wild type. Skotomorphogeneses of brh1 were similar to those of wild type...
March 23, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28407120/biological-versus-mechanical-bentall-procedure-for-aortic-root-replacement-a-propensity-score-analysis-of-a-consecutive-series-of-1112-patients%C3%A2
#11
Antonio Pantaleo, Giacomo Murana, Luca Di Marco, Giuliano Jafrancesco, Giuseppe Barberio, Paolo Berretta, Alessandro Leone, Roberto Di Bartolomeo, Davide Pacini
OBJECTIVES: In this study, a propensity-matching analysis was used to compare biological versus mechanical composite valve graft implantation for early mortality and morbidities and for late complications including the need for aortic reintervention. METHODS: Between 1978 and 2011, 1112 consecutive patients underwent a complete aortic root replacement using either a biological Bentall (BB, n  = 356) or a mechanical Bentall (MB, n  = 756) valve conduit. Preoperative data were stratified according to the type of valve graft, and treatment bias was addressed by propensity score analysis...
April 11, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28407030/intratumoral-heterogeneity-pathways-to-treatment-resistance-and-relapse-in-human-glioblastoma
#12
M A Qazi, P Vora, C Venugopal, S S Sidhu, J Moffat, C Swanton, S K Singh
Intratumoral heterogeneity (ITH) has increasingly being described for multiple cancers as the root cause of therapy resistance. Recent studies have started to explore the scope of ITH in glioblastoma (GBM), a highly aggressive and fatal form of brain tumor, to explain its inevitable therapy resistance and disease relapse. In this review, we detail the emerging data that explores the extensive genetic, cellular and functional ITH present in GBM. We discuss current experimental models of human GBM recurrence and suggest harnessing new technologies (CRISPR-Cas9 screening, CyTOF, cellular barcoding, single cell analysis) to delineate GBM ITH and identify treatment-refractory cell populations, thus opening new therapeutic windows...
April 12, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28403400/association-of-intraoperative-cerebral-and-muscular-tissue-oxygen-saturation-with-postoperative-complications-and-length-of-hospital-stay-after-major-spine-surgery-an-observational-study
#13
L Meng, J Xiao, K Gudelunas, Z Yu, Z Zhong, X Hu
Background.: Compromised tissue oxygenation is one of the root causes of dysfunction of various organs and postoperative complications. Oxygenation of different tissue beds may follow different patterns of change during physiological derangement. Methods.: Patients undergoing elective major posterior spine surgery participated in this prospective observational study. Cerebral tissue oxygen saturation (SctO 2 ) was monitored on the upper forehead and muscular tissue oxygen saturation (SmtO 2 ) on the lower leg...
April 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28400855/ex-vitro-hairy-root-induction-in-detached-peanut-leaves-for-plant-nematode-interaction-studies
#14
Larissa Arrais Guimaraes, Bruna Medeiros Pereira, Ana Claudia Guerra Araujo, Patricia Messenberg Guimaraes, Ana Cristina Miranda Brasileiro
BACKGROUND: Peanut (Arachis hypogaea) production is largely affected by a variety of abiotic and biotic stresses, including the root-knot nematode (RKN) Meloidogyne arenaria that causes yield losses worldwide. Transcriptome studies of wild Arachis species, which harbor resistance to a number of pests and diseases, disclosed several candidate genes for M. arenaria resistance. Peanut is recalcitrant to genetic transformation, so the use of Agrobacterium rhizogenes-derived hairy roots emerged as an alternative for in-root functional characterization of these candidate genes...
2017: Plant Methods
https://www.readbyqxmd.com/read/28393821/spectrophotometric-analysis-of-crown-discoloration-induced-by-two-different-sealers-an-in-vitro-study
#15
Rashmi Keshav Chahande, Sanjay S Patil, Vandana Gade, Rishikesh Meshram, Deepika J Chandhok, Deepa A Thakur
CONTEXT: Endodontic materials have been assessed with regards to their potential for dental staining. AIMS: To evaluate the coronal discoloration effect of Apexit Plus and Resino Seal in mandibular premolars using spectrophotometer. SETTINGS AND DESIGN: The study design was original research. MATERIALS AND METHODS: Forty human single-rooted mandibular first premolar teeth were selected for the study. They were divided into four groups of ten specimens each...
January 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28393269/overexpression-of-sbap37-in-rice-alleviates-concurrent-imposition-of-combination-stresses-and-modulates-different-sets-of-leaf-protein-profiles
#16
Maheshwari Parveda, B Kiran, D L Punita, P B Kavi Kishor
SbAP37 transcription factor contributes to a combination of abiotic stresses when applied simultaneously in rice. It modulates a plethora of proteins that might regulate the downstream pathways to impart salt stress tolerance. APETALA type of transcription factor was isolated from Sorghum bicolor (SbAP37), overexpressed in rice using a salt inducible abscisic acid 2 (ABA2) promoter through Agrobacterium tumefaciens following in planta method. Transgenics were confirmed by PCR amplification of SbAP37, hygromycin phosphotransferase (hptII) marker and ABA2 promoter and DNA blot analysis...
April 9, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28390898/ethylene-response-factor-aterf72-negatively-regulates-arabidopsis-thaliana-response-to-iron-deficiency
#17
Wei Liu, Qiwei Li, Yi Wang, Ting Wu, Yafei Yang, Xinzhong Zhang, Zhenhai Han, Xuefeng Xu
Ethylene regulates the plant's response to stress caused by iron (Fe) deficiency. However, specific roles of ERF proteins in response to Fe deficiency remain poorly understood. Here, we investigated the role of ERF72 in response to iron deficiency in Arabidopsis thaliana. In this study, the levels of the ethylene response factor AtERF72 increased in leaves and roots induced under the iron deficient conditions. erf72 mutant plants showed increased growth compared to wild type (WT) when grown in iron deficient medium for 5 d...
April 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28389078/improving-operating-room-efficiency-in-academic-children-s-hospital-using-lean-six-sigma-methodology
#18
Edward P Tagge, Arul S Thirumoorthi, John Lenart, Carlos Garberoglio, Kenneth W Mitchell
BACKGROUND/PURPOSE: Lean Six Sigma (LSS) is a process improvement methodology that utilizes a collaborative team effort to improve performance by systematically identifying root causes of problems. Our objective was to determine whether application of LSS could improve efficiency when applied simultaneously to all services of an academic children's hospital. METHODS: In our tertiary academic medical center, a multidisciplinary committee was formed, and the entire perioperative process was mapped, using fishbone diagrams, Pareto analysis, and other process improvement tools...
March 18, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28388654/triplin-a-small-molecule-reveals-copper-ion-transport-in-ethylene-signaling-from-atx1-to-ran1
#19
Wenbo Li, Randy F Lacey, Yajin Ye, Juan Lu, Kuo-Chen Yeh, Youli Xiao, Laigeng Li, Chi-Kuang Wen, Brad M Binder, Yang Zhao
Copper ions play an important role in ethylene receptor biogenesis and proper function. The copper transporter RESPONSIVE-TO-ANTAGONIST1 (RAN1) is essential for copper ion transport in Arabidopsis thaliana. However it is still unclear how copper ions are delivered to RAN1 and how copper ions affect ethylene receptors. There is not a specific copper chelator which could be used to explore these questions. Here, by chemical genetics, we identified a novel small molecule, triplin, which could cause a triple response phenotype on dark-grown Arabidopsis seedlings through ethylene signaling pathway...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28387135/analytical-and-numerical-characterization-of-autocorrelation-and-perturbation-correlation-moving-window-methods
#20
Young Jong Lee
Moving-window (MW) approaches to two-dimensional correlation spectroscopy (2D-COS) make it possible to characterize spectral changes occurring in a narrow range of perturbation variable (e.g., time, temperature, and concentration). Despite the wide range of application, the physical meanings of MW correlation intensities have been only qualitatively associated with the direction and curvature of spectral intensity change with regard to a perturbation variable. Here are full and simplified analytical expressions of autocorrelation moving-window (ACMW) and synchronous and asynchronous perturbation-correlation moving-window ( s-PCMW and as-PCMW) intensities...
January 1, 2017: Applied Spectroscopy
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