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Root cause analysis

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https://www.readbyqxmd.com/read/28806951/phytochemical-analysis-and-in-vitro-anthelmintic-activity-of-lophira-lanceolata-ochnaceae-on-the-bovine-parasite-onchocerca-ochengi-and-on-drug-resistant-strains-of-the-free-living-nematode-caenorhabditis-elegans
#1
Justin Kalmobé, Dieudonné Ndjonka, Djafsia Boursou, Jacqueline Dikti Vildina, Eva Liebau
BACKGROUND: Onchocerciasis is one of the tropical neglected diseases (NTDs) caused by the nematode Onchocerca volvulus. Control strategies currently in use rely on mass administration of ivermectin, which has marked activity against microfilariae. Furthermore, the development of resistance to ivermectin was observed. Since vaccine and safe macrofilaricidal treatment against onchocerciasis are still lacking, there is an urgent need to discover novel drugs. This study was undertaken to investigate the anthelmintic activity of Lophira lanceolata on the cattle parasite Onchocerca ochengi and the anthelmintic drug resistant strains of the free living nematode Caenorhabditis elegans and to determine the phytochemical profiles of the extracts and fractions of the plants...
August 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28802433/a-survey-of-the-prevalence-of-fatigue-its-precursors-and-individual-coping-mechanisms-among-u-s-manufacturing-workers
#2
Lin Lu, Fadel M Megahed, Richard F Sesek, Lora A Cavuoto
Advanced manufacturing has resulted in significant changes on the shop-floor, influencing work demands and the working environment. The corresponding safety-related effects, including fatigue, have not been captured on an industry-wide scale. This paper presents results of a survey of U.S. manufacturing workers for the: prevalence of fatigue, its root causes and significant factors, and adopted individual fatigue coping methods. The responses from 451 manufacturing employees were analyzed using descriptive data analysis, bivariate analysis and Market Basket Analysis...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28801485/identifying-discordance-between-senior-physicians-and-trainees-on-the-root-cause-of-ed-revisits
#3
Michael P Goldman, Michael C Monuteaux, Catherine Perron, Richard G Bachur
OBJECTIVE: Analysis of 72-hour ED revisits is a common emergency medicine quality assurance (QA) practice. Our aim was to compare the perceived root cause for 72-hour ED revisits between senior physicians (attendings) and trainees. We proposed that discordance in perception of why the revisit occurred would guide improvements in 72-hour revisits QA and elucidate innovative educational opportunities. METHODS: Questionnaire-based observational study conducted in an urban academic paediatric ED...
August 11, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28800532/cell-cycle-arrest-mediated-by-cd-induced-dna-damage-in-arabidopsis-root-tips
#4
Weina Cui, Hetong Wang, Jie Song, Xia Cao, Hilary J Rogers, Dennis Francis, Chunyun Jia, Lizong Sun, Meifang Hou, Yuesuo Yang, Peidong Tai, Wan Liu
Accumulating evidence demonstrates that the aberrant expression of cell cycle regulation and DNA repair genes can result in abnormal cell proliferation and genomic instability in eukaryotic cells under different stresses. Herein, Arabidopsis thaliana (Arabidopsis) seedlings were grown hydroponically on 0.5 × MS media containing cadmium (Cd) at 0-2.5mgL(-1) for 5d of treatment. Real time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis revealed that expression of DNA damage repair and cell cycle regulation genes, including BRCA1, MRE11, WEE1, CDKA;1 and PCNA1, showed an inverted U-shaped dose-response...
August 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28775360/phenylalanine-ammonia-lyase2-1-contributes-to-the-soybean-response-towards-phytophthora-sojae-infection
#5
Chuanzhong Zhang, Xin Wang, Feng Zhang, Lidong Dong, Junjiang Wu, Qun Cheng, Dongyue Qi, Xiaofei Yan, Liangyu Jiang, Sujie Fan, Ninghui Li, Dongmei Li, Pengfei Xu, Shuzhen Zhang
Phytophthora root and stem rot of soybean [Glycine max (L.) Merr.] caused by Phytophthora sojae is a destructive disease worldwide. Phenylalanine ammonia-lyase (PAL) is one of the most extensively studied enzymes related to plant responses to biotic and abiotic stresses. However, the molecular mechanism of PAL in soybean in response to P. sojae is largely unclear. Here, we characterize a novel member of the soybean PAL gene family, GmPAL2.1, which is significantly induced by P. sojae. Overexpression and RNA interference analysis demonstrates that GmPAL2...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28775143/osbzip48-a-hy5-transcription-factor-ortholog-exerts-pleiotropic-effects-in-light-regulated-development
#6
Naini Burman, Akanksha Bhatnagar, Jitendra P Khurana
Plants have evolved an intricate network of sensory photoreceptors and signalling components to regulate their development. Among the light signalling components identified till date, HY5, a bZIP transcription factor, has been investigated extensively. However, most of the work on HY5 has been carried out in Arabidopsis, a dicot. In this study, based on homology search and phylogenetic analysis, we could identify three homologs of AtHY5 in monocots; however, AtHYH (HY5 homolog) homologs are absent in monocots analysed...
August 3, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28771200/dissecting-tissue-specific-transcriptomic-responses-from-leaf-and-roots-under-salt-stress-in-petunia-hybrida-mitchell
#7
Gonzalo H Villarino, Qiwen Hu, Michael J Scanlon, Lukas Mueller, Aureliano Bombarely, Neil S Mattson
One of the primary objectives of plant biotechnology is to increase resistance to abiotic stresses, such as salinity. Salinity is a major abiotic stress and increasing crop resistant to salt continues to the present day as a major challenge. Salt stress disturbs cellular environment leading to protein misfolding, affecting normal plant growth and causing agricultural losses worldwide. The advent of state-of-the-art technologies such as high throughput mRNA sequencing (RNA-seq) has revolutionized whole-transcriptome analysis by allowing, with high precision, to measure changes in gene expression...
August 3, 2017: Genes
https://www.readbyqxmd.com/read/28769939/evidence-for-active-uptake-and-deposition-of-si-based-defenses-in-tall-fescue
#8
Emma McLarnon, Simon McQueen-Mason, Ingo Lenk, Susan E Hartley
Silicon (Si) is taken up from the soil as monosilicic acid by plant roots, transported to leaves and deposited as phytoliths, amorphous silica (SiO2) bodies, which are a key component of anti-herbivore defense in grasses. Silicon transporters have been identified in many plant species, but the mechanisms underpinning Si transport remain poorly understood. Specifically, the extent to which Si uptake is a passive process, driven primarily by transpiration, or has both passive and active components remains disputed...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28769890/molecular-identification-and-genetic-characterization-of-macrophomina-phaseolina-strains-causing-pathogenicity-on-sunflower-and-chickpea
#9
Ali N Khan, Faluk Shair, Kamran Malik, Zafar Hayat, Muhammad Ayub Khan, Fauzia Yusuf Hafeez, Muhammad Nadeem Hassan
Macrophomina phaseolina is the most devastating pathogen which causes charcoal rot and root rot diseases in various economically important crops. Three strains M. phaseolina 1156, M. phaseolina 1160, and M. phaseolina PCMC/F1 were tested for their virulence on sunflower (Helianthus annuus L.) and chickpea (Cicer arietinum L.). The strains showed high virulence on both hosts with a disease score of 2 on chickpea and sunflower. The strains also increased the hydrogen per oxide (H2O2) content by 1.4- to 1.6-fold in root as well as shoot of chickpea and sunflower...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28769024/nontargeted-metabolomic-analysis-of-four-different-parts-of-platycodon-grandiflorum-grown-in-northeast-china
#10
Cuizhu Wang, Nanqi Zhang, Zhenzhou Wang, Zeng Qi, Hailin Zhu, Bingzhen Zheng, Pingya Li, Jinping Liu
Platycodonis radix is extensively used for treating cough, excessive phlegm, sore throat, bronchitis and asthma in the clinic. Meanwhile, the stems, leaves and seeds of Platycodon grandiflorum (PG) have some pharmaceutical activities such as anti-inflammation and anti-oxidation effects, etc. These effects must be caused by the different metabolites in various parts of herb. In order to profile the different parts of PG, the ultra-high performance liquid chromatography combined with quadrupole time-of- flight mass spectrometry (UPLC-QTOF-MS(E)) coupled with UNIFI platform and multivariate statistical analyses was used in this study...
August 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28767636/comparison-of-symptoms-from-c6-and-c7-radiculopathy
#11
James Rainville, Andrew A Joyce, Eric Laxer, Enrique Pena, David Kim, R Alden Milam, Eric Carkner
STUDY DESIGN: Case series. OBJECTIVE: This study compared the locations of arm pain, sensory symptoms, and subjective complaints of arm weakness in subjects with cervical radiculopathy from MRI confirmed C6 and C7 nerve root compression. SUMMARY OF BACKGROUND DATA: Cervical radiculopathy is defined as arm pain, sensory and motor symptoms caused by irritation of a cervical nerve root. The C6 and C7 roots are most commonly involved, and differentiating symptoms associated with each root has proven difficult...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28752939/effect-of-organic-silicon-methylsulfonylmethane-and-glucosamine-sulfate-in-mandibular-bone-defects-in-rats
#12
Flávia Santiago de Sousa Rosa, Rúbia Teodoro Stuepp, Filipe Modolo, Michelle Tillmann Biz
Organic silicon (OS), glucosamine sulfate (GS), and methylsulfonylmethane (MSM) have been related to bone and connective tissue health and have been considered as basic therapy for osteoarthrosis disorders. Therefore, the aim was to analyze the effect of the association of these three components in mandibular bone defects in rats. Nine rats were used for histocompatibility test. In each animal was implanted the composition (70% OS, 15% GS, 15% MSM) and gutta percha (control) under the dorsal subcutaneous tissue...
July 28, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28749067/haemolysis-in-haemodialysis
#13
REVIEW
Dhakshayini Tharmaraj, Peter G Kerr
Haemolysis in haemodialysis, although rare in current times, is associated with significant mortality and morbidity. As such prompt recognition, treatment, analysis of root cause and correction of underlying causative factors is crucial. Dialysate, extracorporeal circuit and patient related factors all contribute to haemolysis risk. Haemolysis can manifest with non-specific signs and symptoms including but not restricted to hypertension, nausea, pain (abdominal, chest, back) and dyspnoea. It may present acutely during the dialysis session or may take a protracted course...
July 27, 2017: Nephrology
https://www.readbyqxmd.com/read/28746752/immunotherapy-for-diabetic-amyotrophy
#14
REVIEW
Yee Cheun Chan, Yew Long Lo, Edwin Sy Chan
BACKGROUND: People with diabetes mellitus (DM) sometimes present with acute or subacute, progressive, asymmetrical pain and weakness of the proximal lower limb muscles. The various names for the condition include diabetic amyotrophy, diabetic lumbosacral radiculoplexus neuropathies, diabetic femoral neuropathy or Bruns-Garland syndrome. Some studies suggest that diabetic amyotrophy may be an immune-mediated inflammatory microvasculitis causing ischaemic damage of the nerves. Immunotherapies would therefore be expected to be beneficial...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28746745/apical-stress-distribution-under-vertical-compaction-of-gutta-percha-and-occlusal-loads-in-canals-with-varying-apical-sizes-a-3-dimensional-finite-element-analysis
#15
K Yuan, C Niu, Q Xie, W Jiang, L Gao, R Ma, Z Huang
AIM: To investigate and compare the effects of two apical canal instrumentation protocols on apical stress distributions at the root apex under vertical compaction of gutta-percha and occlusal loads using finite element analysis. METHODOLOGY: Three finite element analysis models of a mandibular first premolar were reconstructed: an original canal model, a size 35, 0.04 taper apical enlargement model and a Lightspeed size 60 apical enlargement model. A 15 N compaction force was applied vertically to the gutta-percha 5 mm from the apex...
July 26, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28744296/metabolomic-analysis-of-alfalfa-medicago-sativa-l-root-symbiotic-rhizobia-responses-under-alkali-stress
#16
Tingting Song, Huihui Xu, Na Sun, Liu Jiang, Pu Tian, Yueyuan Yong, Weiwei Yang, Hua Cai, Guowen Cui
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relationships such as alfalfa (Medicago sativa L.). Therefore, a study was designed to evaluate the metabolic response of the root-nodule symbiosis in alfalfa under alkali stress using comparative metabolomics. Rhizobium-nodulized (RI group) and non-nodulized (NI group) alfalfa roots were treated with 200 mmol/L NaHCO3 and, roots samples were analyzed for malondialdehydyde (MDA), proline, glutathione (GSH), superoxide dismutase (SOD), and peroxidase (POD) content...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28742855/decreases-in-heart-rate-variability-are-associated-with-postoperative-complications-in-hip-fracture-patients
#17
Gernot Ernst, Leiv Otto Watne, Frede Frihagen, Torgeir Bruun Wyller, Andreas Dominik, Morten Rostrup
BACKGROUND: To explore relevant associations between deviations in linear and nonlinear heart rate variability (HRV) scores, and short-term morbidity and mortality in patients undergoing hip-surgery after a fracture. METHODS: 165 patients with hip fractures being admitted for surgery at two hospitals were included in a prospective cohort study. A short-term ECG was recorded within 24 hours of arrival. 15 patients had to be excluded due to insufficient quality of the ECG recordings...
2017: PloS One
https://www.readbyqxmd.com/read/28742258/metabolite-profiling-of-non-sterile-rhizosphere-soil
#18
Pierre Pétriacq, Alex Williams, T E Anne Cotton, Alexander E McFarlane, Stephen A Rolfe, Jurriaan Ton
Rhizosphere chemistry is the sum of root exudation chemicals, their breakdown products and microbial products of soil-derived chemicals. To date, most studies about root exudation chemistry are based on sterile cultivation systems, which limits the discovery of microbial breakdown products that act as semiochemicals and shape microbial rhizosphere communities. Here, we present a method for untargeted metabolic profiling of non-sterile rhizosphere soil. We have developed an experimental growth system that enables collection and analysis of rhizosphere chemicals from different plant species...
July 25, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28739476/severity-of-foraminal-lumbar-stenosis-and-the-relation-to-clinical-symptoms-and-response-to-periradicular-infiltration-introduction-of-the-melting-sign
#19
M Farshad, R Sutter, A Hoch
BACKGROUND CONTEXT: Nerve root compression causing symptomatic radiculopathy can occur within the intervertebral foramen. Sagittal MRI sequences are reliable in detection of nerve root contact to intraforaminal disc material, but a clinically relevant classification of degree of contact is lacking. PURPOSE: To investigate a potential relation of amount of contact between intraforaminal disc material and nerve root to clinical findings and response after periradicular corticosteroid infiltration...
July 21, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28735792/dynamic-torque-and-vertical-force-analysis-during-nickel-titanium-rotary-root-canal-preparation-with-different-modes-of-reciprocal-rotation
#20
Daisuke Tokita, Arata Ebihara, Miki Nishijo, Kana Miyara, Takashi Okiji
INTRODUCTION: The purpose of the present study was to compare 2 modes of reciprocal movement (torque-sensitive and time-dependent reciprocal rotation) with continuous rotation in terms of torque and apical force generation during nickel-titanium rotary root canal instrumentation. METHODS: A custom-made automated root canal instrumentation and torque/force analyzing device was used to prepare simulated canals in resin blocks and monitor the torque and apical force generated in the blocks during preparation...
July 20, 2017: Journal of Endodontics
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