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Root cause analysis

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https://www.readbyqxmd.com/read/28549909/poor-quality-and-counterfeit-drugs-a-systematic-assessment-of-prevalence-and-risks-based-on-data-published-from-2007-2016
#1
Andreas Koczwara, Jennifer Dressman
Counterfeit drugs can hurt patients and harm the pharmaceutical industry. In 2006, the International Medical Products Anti-Counterfeiting Taskforce expressed a need to generate more and better data to calculate a worldwide prevalence of counterfeiting. This review analyzes field test data that were published in the time-frame January 2007 to December 2016, were accessible via Pubmed, and which addressed the prevalence of counterfeit drugs. Based on the 41 studies identified, it is still not possible to make a reliable statement about the prevalence of counterfeit drugs due to the heterogeneity of the results...
May 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28549197/analysis-of-protein-profile-of-tomato-root-infected-with-fusarium-oxysporum-f-sp-lycopersici
#2
T D Silva, C M A Almeida, C B Malafaia, L M S Oliveira, M V Silva, M T S Correia
Fusarium wilt caused by Fusarium oxysporum f. sp lycopersici (Fol) is one of the main diseases affecting tomatoes. The BHRS 2,3 genotype of tomato is, however, resistant to this disease. A proteomic approach was used to understand the defense mechanisms of this genotype using the tomato root, the first tissue that interacts with the fungus, as a target. Protein was extracted and separated by two-dimensional electrophoresis followed by staining with Coomassie brilliant blue. The proteins were identified by MALDI-TOF/TOF mass spectrometry...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28546538/droplet-digital-pcr-versus-qpcr-for-gene-expression-analysis-with-low-abundant-targets-from-variable-nonsense-to-publication-quality-data
#3
Sean C Taylor, Genevieve Laperriere, Hugo Germain
Quantitative PCR (qPCR) has become the gold standard technique to measure cDNA and gDNA levels but the resulting data can be highly variable, artifactual and non-reproducible without appropriate verification and validation of both samples and primers. The root cause of poor quality data is typically associated with inadequate dilution of residual protein and chemical contaminants that variably inhibit Taq polymerase and primer annealing. The most susceptible, frustrating and often most interesting samples are those containing low abundant targets with small expression differences of 2-fold or lower...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28545653/systematic-approaches-to-adverse-events-in-obstetrics-part-ii-event-analysis-and-response
#4
Christian M Pettker
The critical arm of improvement and change comes after events are identified and classified. Getting and making things right when things go wrong defines a successful safety program. This article reviews the important tasks that should be familiar to any team approaching a serious event on an obstetrics unit. Root cause analysis is a critical, but often misunderstood, tool for dissecting the contributing factors leading to an adverse event. Successful root cause analyses have a standardized approach that result in meaningful action plans...
May 22, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28536855/rotational-laxity-control-by-the-anterolateral-ligament-and-the-lateral-meniscus-is-dependent-on-knee-flexion-angle-a-cadaveric-biomechanical-study
#5
Timothy Lording, Gillian Corbo, Dianne Bryant, Timothy A Burkhart, Alan Getgood
BACKGROUND: Injury to the anterolateral ligament (ALL) has been reported to contribute to high-grade anterolateral laxity after anterior cruciate ligament (ACL) injury. Failure to address ALL injury has been suggested as a cause of persistent rotational laxity after ACL reconstruction. Lateral meniscus posterior root (LMPR) tears have also been shown to cause increased internal rotation of the knee. QUESTIONS/PURPOSES: The purpose of this study was to determine the functional relationship between the ALL and LMPR in the control of internal rotation of the ACL-deficient knee...
May 23, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28536713/calibration-transfer-of-near-infrared-spectroscopy-by-canonical-correlation-analysis-coupled-with-wavelet-transform
#6
Jun Bin, Xin Li, Wei Fan, Ji-Heng Zhou, Cheng-Wei Wang
Calibration model transfer has played a prominent role in the practical application of NIR spectral analysis. The change of instruments and sample physical states may lead to variation of the NIR spectrum, which results in the applicability of the model in judicatory practice being unsatisfactory. Therefore, a transfer for the calibration model considering both the variation of instruments and sample states is a necessity to ensure its availability. In this paper, a novel approach, namely canonical correlation analysis coupled with wavelet transform (WTCCA), was proposed for calibration transfer between two near infrared spectrometers (a portable and a laboratory instrument), and simultaneously, among three physical states (tobacco powder, tobacco filament and intact leaf) to determine the content of total sugars, reducing sugars, and nicotine in tobacco leaf samples, respectively...
May 24, 2017: Analyst
https://www.readbyqxmd.com/read/28535564/the-different-dynamic-changes-of-nerve-growth-factor-in-the-dorsal-horn-and-dorsal-root-ganglion-leads-to-hyperalgesia-and-allodynia-in-diabetic-neuropathic-pain
#7
Zhifeng Gao, Yi Feng, Hui Ju
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and more than half of the patients with DPN have self-reported symptoms referring to painful diabetic neuropathy (PDN). Nerve growth factor (NGF) is a key factor for the nervous system, but the role of it in the neuropathic pain of diabetic patients is unclear. OBJECTIVE: This study aimed to investigate the relationship between the dynamic expression of NGF in dorsal horn and dorsal root ganglion (DRG) of diabetic rats and hyperalgesia and allodynia in diabetic neuropathic pain...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28533982/lid-opening-and-conformational-stability-of-t1-lipase-is-mediated-by-increasing-chain-length-polar-solvents
#8
Jonathan Maiangwa, Mohd Shukuri Mohamad Ali, Abu Bakar Salleh, Raja Noor Zaliha Raja Abd Rahman, Yahaya M Normi, Fairolniza Mohd Shariff, Thean Chor Leow
The dynamics and conformational landscape of proteins in organic solvents are events of potential interest in nonaqueous process catalysis. Conformational changes, folding transitions, and stability often correspond to structural rearrangements that alter contacts between solvent molecules and amino acid residues. However, in nonaqueous enzymology, organic solvents limit stability and further application of proteins. In the present study, molecular dynamics (MD) of a thermostable Geobacillus zalihae T1 lipase was performed in different chain length polar organic solvents (methanol, ethanol, propanol, butanol, and pentanol) and water mixture systems to a concentration of 50%...
2017: PeerJ
https://www.readbyqxmd.com/read/28533981/effects-of-knee-sleeves-on-coordination-of-lower-limb-segments-in-healthy-adults-during-level-walking-and-one-leg-hopping
#9
Chang-Yong Ko, Yunhee Chang, Bora Jeong, Sungjae Kang, Jeicheong Ryu, Gyoosuk Kim
The evaluation of multisegment coordination is important in gaining a better understanding of the gait and physical activities in humans. Therefore, this study aims to verify whether the use of knee sleeves affects the coordination of lower-limb segments during level walking and one-leg hopping. Eleven healthy male adults participated in this study. They were asked to walk 10 m on a level ground and perform one-leg hops with and without a knee sleeve. The segment angles and the response velocities of the thigh, shank, and foot were measured and calculated by using a motion analysis system...
2017: PeerJ
https://www.readbyqxmd.com/read/28532410/malaria-mortality-characterization-and-the-relationship-between-malaria-mortality-and-climate-in-chimoio-mozambique
#10
João Luís Ferrão, Jorge M Mendes, Marco Painho, Sara Zacarias
BACKGROUND: The United Nation's sustainable development goal for 2030 is to eradicate the global malaria epidemic, primarily as the disease continues to be one of the major concerns for public health in sub-Saharan Africa. In 2015, the region accounted for 90% of malaria deaths. Mozambique recorded a malaria mortality rate of 42.75 (per 100,000). In Chimoio, Mozambique's fifth largest city, malaria is the fourth leading cause of death (9.4%). Few data on malaria mortality exists in Mozambique, particularly in relation to Chimoio...
May 22, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28528624/root-cause-analysis-of-adverse-events-in-an-outpatient-anticoagulation-management-consortium
#11
Christopher M Graves, Brian Haymart, Eva Kline-Rogers, Geoffrey D Barnes, Linda K Perry, Denise Pluhatsch, Nannette Gearhart, Helen Gikas, Noelle Ryan, Brian Kurtz
BACKGROUND: A number of factors can lead to adverse events (AEs) in patients taking warfarin. Performing a root cause analysis (RCA) of serious AEs is one systematic way of determining the causes of these events. METHODS: Multidisciplinary teams were formed at Michigan Anticoagulation Quality Improvement Initiative (MAQI(2)) sites with organized anticoagulation management services (AMS). Medical records from patients who suffered serious AEs (major bleed, embolic stroke, venous thromboembolism) were reviewed, and AMS staff were interviewed to determine the root cause using the "5 Whys" technique...
June 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28513789/effect-of-final-irrigation-protocols-on-microhardness-reduction-and-erosion-of-root-canal-dentin
#12
Flávia Emi Razera Baldasso, Luana Roleto, Vinicius Duval da Silva, Renata Dornelles Morgental, Patrícia Maria Poli Kopper
This study aimed to evaluate the effect of final irrigation protocols on microhardness reduction and erosion of root canal dentin. Sixty root canals from mandibular incisors were instrumented and randomly divided into six groups (n = 10) according to the irrigant used: QMiX, 17% EDTA, 10% citric acid (CA), 1% peracetic acid (PA), 2.5% NaOCl (solution control), and distilled water (negative control). The chelating solutions were used to irrigate the canal followed by 2.5% NaOCl as a final flush. After the irrigation protocols, all specimens were rinsed with 10 mL of distilled water to remove any residue of the chemical solutions...
May 15, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28512468/molecular-identification-and-karyological-analysis-of-a-rampant-aspen-populus-tremula-l-salicaceae-clone
#13
Dmitry V Politov, Yuri S Belokon, Anna V Shatokhina, Maryana M Belokon, Nail A Khanov, Elena A Mudrik, Tatyana A Polyakova, Anna B Azarova, Konstantin A Shestibratov
A rampant highly heterozygous aspen (Populus tremula L.) clone "Meshabash" has been revealed in course of population genetic diversity analysis in a native stand in the Republic of Tatarstan, Russia. Here we report the results of karyological analysis showing that this highly vigorous clone is diploid (2n = 38) while typically triploid aspen demonstrates increased growth rate and resistance to aspen trunk rot caused by fungus Phellinus tremulae. By means of DNA identification of a series of model trees using 14 SSR loci we outlined the area occupied by this clone (at least 1...
2017: International Journal of Plant Genomics
https://www.readbyqxmd.com/read/28512464/insights-into-the-mechanism-of-proliferation-on-the-special-microbes-mediated-by-phenolic-acids-in-the-radix-pseudostellariae-rhizosphere-under-continuous-monoculture-regimes
#14
Hongmiao Wu, Junjian Xu, Juanying Wang, Xianjin Qin, Linkun Wu, Zhicheng Li, Sheng Lin, Weiwei Lin, Quan Zhu, Muhammad U Khan, Wenxiong Lin
As potent allelochemicals, phenolic acids are believed to be associated with replanting disease and cause microflora shift and structural disorder in the rhizosphere soil of continuously monocultured Radix pseudostellariae. The transcriptome sequencing was used to reveal the mechanisms underlying the differential response of pathogenic bacterium Kosakonia sacchari and beneficial bacterium Bacillus pumilus on their interactions with phenolic acids, the main allelochemicals in root exudates of R. pseudostellariae in the monoculture system...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28511504/prevalence-of-distal-caries-in-mandibular-second-molar-due-to-impacted-third-molar
#15
Kamran Bokhari Syed, Fatima Saeed Alshahrani, Wejdan Saad Alabsi, Zainab Ali Alqahtani, Mohammad Shahul Hameed, Abdel Bagi Mustafa, Tanveer Alam
INTRODUCTION: A tooth is said to be impacted if it does not reach the occlusal plane even after two-thirds root formation. The aetiology of impacted teeth is varied and multi-factorial. Significant problems associated with impacted teeth include trismus, infection, cervical caries of second molars. AIM: This study was aimed to assess the prevalence of distal caries in second molar teeth due to impacted third molars and to compare with similar studies conducted elsewhere...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511191/death-by-suicide-within-1-week-of-hospital-discharge-a-retrospective-study-of-root-cause-analysis-reports
#16
Natalie Riblet, Brian Shiner, Bradley V Watts, Peter Mills, Brett Rusch, Robin R Hemphill
There is a high risk for death by suicide after discharge from an inpatient mental health unit. To better understand system and organizational factors associated with postdischarge suicide, we reviewed root cause analysis reports of suicide within 7 days of discharge from across all Veterans Health Administration inpatient mental health units between 2002 and 2015. There were 141 reports of suicide within 7 days of discharge, and a large proportion (43.3%, n = 61) followed an unplanned discharge. Root causes fell into three major themes including challenges for clinicians and patients after the established process of care, awareness and communication of suicide risk, and flaws in the established process of care...
May 16, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28510484/ethylene-signalling-is-important-for-isoflavonoid-mediated-resistance-to-rhizoctonia-solani-in-roots-of-medicago-truncatula
#17
Yao Liu, Samira Hassan, Brendan N Kidd, Gagan Garg, Ulrike Mathesius, Karam B Singh, Jonathan Anderson
The root-infecting necrotrophic fungal pathogen Rhizoctonia solani causes significant disease to all the world's major food crops. As a model for pathogenesis of legumes, we have examined the interaction of R. solani AG8 with Medicago truncatula. RNAseq analysis of the moderately resistant M. truncatula accession A17 and highly susceptible sickle (skl) mutant (defective in ethylene sensing) identified major early transcriptional reprogramming in A17. Responses specific to A17 included components of ethylene signalling, reactive oxygen species metabolism and consistent up-regulation of the isoflavonoid biosynthesis pathway...
May 16, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28507603/fingolimod-initiation-in-multiple-sclerosis-patients-is-associated-with-potential-beneficial-cardiovascular-autonomic-effects
#18
Max J Hilz, Ruihao Wang, Carmen de Rojas Leal, Mao Liu, Francesca Canavese, Sankanika Roy, Katharina M Hösl, Klemens Winder, De-Hyung Lee, Ralf A Linker
BACKGROUND: Fingolimod slows heart rate (HR) due to vagomimetic effects and might cause additional cardiovascular autonomic changes. While the time course of HR changes is well described, the extent and course of cardiovascular autonomic changes upon fingolimod initiation has not yet been evaluated. This study, therefore, intended to assess cardiovascular autonomic changes during the first 6 h after fingolimod initiation. METHODS: In 21 patients with relapsing-remitting multiple sclerosis (RRMS), we recorded respiration (RESP), electrocardiographic RR interval (RRI), systolic and diastolic blood pressure (BPsys, BPdia) at rest, before and 0...
April 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28500668/advanced-multivariate-data-analysis-to-determine-the-root-cause-of-trisulfide-bond-formation-in-a-novel-antibody-peptide-fusion
#19
Stephen Goldrick, William Holmes, Nick Bond, Gareth Lewis, Marcel Kuiper, Richard Turner, Suzanne S Farid
Product quality heterogeneities, such as a trisulfide bond (TSB) formation, can be influenced by multiple interacting process parameters. Identifying their root cause is a major challenge in biopharmaceutical production. To address this issue, this paper describes the novel application of advanced multivariate data analysis (MVDA) techniques to identify the process parameters influencing TSB formation in a novel recombinant antibody-peptide fusion expressed in mammalian cell culture. The screening dataset was generated with a high-throughput (HT) micro-bioreactor system (Ambr(TM) 15) using a design of experiments (DoE) approach...
May 13, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28499438/early-developed-asd-adjacent-segmental-disease-in-patients-after-surgical-treatment-of-the-spine-due-to-cancer-metastases
#20
Grzegorz Guzik
BACKGROUND: The causes of ASD are still relatively unknown. Correlation between clinical status of patients and radiological MRI findings is of primary importance. The radiological classifications proposed by Pfirmann and Oner are most commonly used to assess intradiscal degenerative changes. The aim of the study was to assess the influence of the extension of spine fixation on the risk of developing ASD in a short time after surgery. METHODS: A total of 332 patients with spinal tumors were treated in our hospital between 2010 and 2013...
May 12, 2017: Journal of Orthopaedic Surgery and Research
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