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Root cause analysis

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https://www.readbyqxmd.com/read/28318148/barriers-to-innovation-in-human-rabies-prophylaxis-and-treatment-a-causal-analysis-of-insights-from-key-opinion-leaders-and-literature
#1
L H M van de Burgwal, A M G Neevel, C A C M Pittens, A D M E Osterhaus, C E Rupprecht, E Claassen
Rabies is an essentially 100% fatal, zoonotic disease, caused by Lyssaviruses. Currently, the disease is vaccine-preventable with pre- and post-exposure prophylaxis (PrEP and PEP). Still, rabies virus is estimated to cause up to 60,000 human deaths annually, of which the vast majority occurs in rural Asia and Africa, due to the inaccessibility of prophylaxis and non-existence of treatment. Despite these unmet clinical needs, rabies control mainly focuses on the sylvatic reservoir and drug innovation receives relatively little attention compared to other neglected tropical diseases (NTDs)...
March 20, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28315612/ultrasound-assessment-of-peripheral-nerve-pathology-in-neurofibromatosis-type-1-and-2
#2
Natalie Winter, Tim W Rattay, Hubertus Axer, Eva Schäffer, Bernhard F Décard, Isabel Gugel, Martin Schuhmann, Alexander Grimm
OBJECTIVE: The neurofibromatoses (NF) type 1 and 2 are hereditary tumor predisposition syndromes caused by germline mutations in the NF1 and NF2 tumor suppressor genes. In NF1 and 2, peripheral nerve tumors occur regularly. For further characterizing nerve ultrasound was performed in patients with NF1 and 2. METHODS: Patients with established diagnosis of NF1 (n=27) and NF2 (n=10) were included. Ultrasound of peripheral nerves and cervical roots was performed during routine follow-up visits...
February 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28303252/evaluation-of-the-biocontrol-potential-of-purpureocillium-lilacinum-qlp12-against-verticillium-dahliae-in-eggplant
#3
Xingjie Lan, Jing Zhang, Zhaofeng Zong, Qing Ma, Yang Wang
A fungus with broad spectrum antifungal activity was isolated from the soil in Qinling Mountain, Shaanxi Province, in China. The fungus was identified as Purpureocillium lilacinum based on ITS rDNA gene analysis. The strain, coded as QLP12, showed high inhibition activity on fungal mycelium growth in vitro, especially to Mucor piriformis, Trichothecium roseum, Rhizoctonia solani, and Verticillium dahliae, and its potential for biocontrol efficacy of eggplant. Verticillium wilt disease caused by Verticillium dahliae among 10 fungal species tested was explored...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28302433/improving-water-quality-in-a-dialysis-unit-using-root-cause-analysis
#4
Pallavi Yadav, Dawn England, Caprice Vanderkolk, Pui-Ying Iroh Tam
BACKGROUND: Water quality levels from hemodialysis (HD) and reverse osmosis (RO) machines in dialysis units must meet standards set by the American Association of Medical Instrumentation. Researchers used a root cause analysis (RCA) approach to identify and address factors affecting water quality in the HD and portable RO machines at our institution. METHODS: A multidisciplinary team reviewed processes, interviewed staff members, and identified opportunities to improve the current sampling and machine disinfection processes...
March 13, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28297338/epid-based-in-vivo-dosimetry-system-clinical-experience-and-results
#5
Sofia Celi, Emilie Costa, Claas Wessels, Alejandro Mazal, Alain Fourquet, Pascal Francois
Mandatory in several countries, in vivo dosimetry has been recognized as one of the next milestones in radiation oncology. Our department has implemented clinically an EPID based in vivo dosimetry system, EPIgray, by DOSISOFT S.A., since 2006. An analysis of the measurements per linac and energy over a two-year period was performed, which included a more detailed examination per technique and treatment site over a six-month period. A comparison of the treatment planning system doses and the doses estimated by EPIgray shows a mean of the differences of 1...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296918/calcium-dependent-protein-kinase-cpk31-interacts-with-arsenic-transporter-atnip1-1-and-regulates-arsenite-uptake-in-arabidopsis-thaliana
#6
Ruijie Ji, Liming Zhou, Jinglong Liu, Yuan Wang, Lei Yang, Qinsong Zheng, Chi Zhang, Bin Zhang, Haiman Ge, Yonghua Yang, Fugeng Zhao, Sheng Luan, Wenzhi Lan
Although arsenite [As(III)] is non-essential and toxic for plants, it is effectively absorbed through various transporters into the roots. Here we identified a calcium-dependent protein kinase (CPK31) response for As(III) tolerance in Arabidopsis. We identified CPK31 as an interacting protein of a nodulin 26-like intrinsic protein (NIP1;1), an aquaporin involved in As(III) uptake. Similarly to the nip1;1 mutants, the loss-of-function mutants of CPK31 improved the tolerance against As(III) but not As(V), and accumulated less As(III) in roots than that of the wild-type plants...
2017: PloS One
https://www.readbyqxmd.com/read/28296641/root-cause-analysis-of-deaths-in-st-segment-elevation-myocardial-infarctions-treated-with-primary-pci-what-can-we-do-better
#7
Fredy El Sakr, Mohamad Kenaan, Daniel Menees, Milan Seth, Hitinder S Gurm
OBJECTIVE: Recent data demonstrate that mortality of patients with ST-elevation myocardial infarction (STEMI) has not changed despite dramatic reduction in door-to-balloon times. Identifying potential areas in care that can be further optimized to decrease mortality remains a priority. METHODS: We performed a root cause analysis of all patients who died following primary percutaneous coronary intervention (PCI) during index hospitalization from 2008 to 2013 at the University of Michigan...
March 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28295540/v-atpases-containing-a3-subunit-play-a-direct-role-in-enamel-development-in-mice
#8
Lisa Johnson, Bernhard Ganss, Andrew Wang, Ralph A Zirngibl, Danielle E Johnson, Celeste Owen, Grace Bradley, Irina Voronov
Vacuolar H(+) -ATPases (V-ATPases) are ubiquitous multisubunit proton pumps responsible for organellar pH maintenance. Mutations in the a3 subunit of V-ATPases cause autosomal recessive osteopetrosis; a rare disease due to impaired bone resorption. Patients with osteopetrosis also display dental anomalies, such as enamel defects; however, it is not clear whether these enamel abnormalities are a direct consequence of the a3 mutations. We investigated enamel mineralization, spatiotemporal expression of enamel matrix proteins and the a3 protein during tooth development using an osteopetrotic mouse model with a R740S point mutation in the V-ATPase a3 subunit...
March 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28293388/protective-role-of-licochalcone-b-against-ethanol-induced-hepatotoxicity-through-regulation-of-erk-signaling
#9
Xiao-Peng Gao, Dong-Wei Qian, Zhen Xie, Hao Hui
OBJECTIVES: Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an in vitro study. MATERIALS AND METHODS: An in vitro model of Ethanol-induced cytotoxicity in BRL cells was used in this study. Cell injury was assessed using WST-1 assay and lactate dehydrogenase, alanine transaminase, and aspartate aminotransferase release assay...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28292596/why-biphasic-assessment-of-the-effect-on-cell-proliferation-and-expression
#10
Pierre Schembri-Wismayer, Josette Camilleri
INTRODUCTION: Tricalcium silicate (TCS)-based materials are used in endodontics because they are hydraulic and interact with blood, tissue fluids, and phosphate-based root canal irrigants, resulting in biomineralization. Newer-generation materials are biphasic; calcium phosphate is added to the TCS; thus, the material has 2 cementitious phases. The effect of this addition is not known; thus, the aim of this study was to characterize biphasic cements and assess cellular proliferation and expression...
March 11, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28292195/phytotoxic-activity-and-chemical-composition-of-cassia-absus-seeds-and-aerial-parts
#11
I Zribi, H Sbai, N Ghezal, G Richard, D Trisman, M L Fauconnier, R Haouala
The present study was conducted to assess the phytotoxic potential and the phytochemical composition of Cassia absus. Aqueous extracts caused significant reduction in root growth of Lactuca sativa. Seed extract was more effective than aerial part extract. Successive extractions of this plant were performed using solvents with increasing polarities. The methanolic seed extract exerted strong phytotoxic effect on seedling growth, followed by petroleum ether extract of the aerial part. The phytochemical investigation showed that among the organic extracts, methanol extracts of seeds and aerial parts contained the highest amounts of total phenolics and proanthocyanidins...
March 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28291411/the-impact-of-preoperative-epidural-injections-on-postoperative-infection-in-lumbar-fusion-surgery
#12
Anuj Singla, Scott Yang, Brian C Werner, Jourdan M Cancienne, Ali Nourbakhsh, Adam L Shimer, Hamid Hassanzadeh, Francis H Shen
OBJECTIVE Lumbar epidural steroid injections (LESIs) are performed for both diagnostic and therapeutic purposes for a variety of indications, including low-back pain, the leading cause of disability and expense due to work-related conditions in the US. The steroid agent used in epidural injections is reported to relieve nerve root inflammation, local ischemia, and resultant pain, but the injection may also have an adverse impact on spinal surgery performed thereafter. In particular, the possibility that preoperative epidural injections may increase the risk of surgical site infection after lumbar spinal fusion has been reported but has not been studied in detail...
March 14, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28290953/chief-of-residents-for-quality-improvement-and-patient-safety-a-recipe-for-a-new-role-in-graduate-medical-education
#13
Kelly Ferraro, Randall Zernzach, Stephen Maturo, Christopher Nagy, Rebecca Barrett
INTRODUCTION: The San Antonio Uniformed Services Health Education Consortium (SAUSHEC) is the largest group of residency programs in the Department of Defense. In an effort to provide improved Quality Improvement and Patient Safety (QI/PS) training for its residents, SAUSHEC created the position of Chief of QI/PS for Residents in the academic year 2014-2015. The Chief of QI/PS for Residents was based in the Internal Medicine residency program but also assisted with SAUSHEC-wide QI/PS projects...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28288664/injured-bodies-damaged-lives-experiences-and-narratives-of-kenyan-women-with-obstetric-fistula-and-female-genital-mutilation-cutting
#14
Lillian Mwanri, Glory Joy Gatwiri
BACKGROUND: It is well acknowledged that Female Genital Mutilation/Cutting (FGM/C/C) leads to medical, psychological and sociocultural sequels. Over 200 million cases of FGM/C exist globally, and in Kenya alone, a total of 12,418,000 (28%) of women have undergone FGM/C, making the practice not only a significant national, but also a global health catastrophe. FGM/C is rooted in patriarchal and traditional cultures as a communal experience signifying a transition from girlhood to womanhood...
March 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28277328/isobolographic-analysis-of-drug-combinations-with-intrathecal-brl52537-%C3%AE%C2%BA-opioid-agonist-pregabalin-calcium-channel-modulator-af-353-p2x3-receptor-antagonist-and-a804598-p2x7-receptor-antagonist-in-neuropathic-rats
#15
Young-Hwan Jung, Yeo Ok Kim, Jung Hyun Han, Yong-Chul Kim, Myung Ha Yoon
BACKGROUND: Neuropathic pain should be treated with drug combinations exhibiting multiple analgesic mechanisms of action because the mechanism of neuropathic pain involves multiple physiological causes and is mediated by multiple pathways. In this study, we defined the pharmacological interaction of BRL52537 (κ-opioid agonist), pregabalin (calcium channel modulator), AF 353 (P2X3 receptor antagonist), and A804598 (P2X7 receptor antagonist). METHODS: Animal models of neuropathic pain were established by spinal nerve ligation (SNL) in male Sprague-Dawley rats, and responses to the mechanical stimulation using von Frey filaments were measured...
March 8, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28275816/genetic-mapping-and-haplotype-analysis-of-a-locus-for-quantitative-resistance-to-fusarium-graminearum-in-soybean-accession-pi-567516c
#16
Peng Cheng, Cassidy R Gedling, Gunvant Patil, Tri D Vuong, J Grover Shannon, Anne E Dorrance, Henry T Nguyen
A major novel quantitative disease resistance locus, qRfg_Gm06, for Fusarium graminearum was genetically mapped to chromosome 6. Genomic-assisted haplotype analysis within this region identified three putative candidate genes. Fusarium graminearum causes seed, root rot, and seedling damping-off in soybean which contributes to reduced stands and yield. A cultivar Magellan and PI 567516C were identified with low and high levels of partial resistance to F. graminearum, respectively. Quantitative disease resistance loci (QDRL) were mapped with 241 F7:8 recombinant inbred lines (RILs) derived from a cross of Magellan × PI 567516C...
March 8, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28274036/effect-of-instrumentation-length-and-instrumentation-systems-hand-versus-rotary-files-on-apical-crack-formation-an-in-vitro-study
#17
Madhuri R Devale, M C Mahesh, Shreetha Bhandary
INTRODUCTION: Stresses generated during root canal instrumentation have been reported to cause apical cracks. The smaller, less pronounced defects like cracks can later propagate into vertical root fracture, when the tooth is subjected to repeated stresses from endodontic or restorative procedures. AIM: This study evaluated occurrence of apical cracks with stainless steel hand files, rotary NiTi RaCe and K3 files at two different instrumentation lengths. MATERIALS AND METHODS: In the present in vitro study, 60 mandibular premolars were mounted in resin blocks with simulated periodontal ligament...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273088/depletion-of-arabidopsis-sc35-and-sc35-like-serine-arginine-rich-proteins-affects-the-transcription-and-splicing-of-a-subset-of-genes
#18
Qingqing Yan, Xi Xia, Zhenfei Sun, Yuda Fang
Serine/arginine-rich (SR) proteins are important splicing factors which play significant roles in spliceosome assembly and splicing regulation. However, little is known regarding their biological functions in plants. Here, we analyzed the phenotypes of mutants upon depleting different subfamilies of Arabidopsis SR proteins. We found that loss of the functions of SC35 and SC35-like (SCL) proteins cause pleiotropic changes in plant morphology and development, including serrated leaves, late flowering, shorter roots and abnormal silique phyllotaxy...
March 8, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28269088/an-analysis-of-sounds-for-lungs-with-excessive-water
#19
Kah Jun Hong, Wee Ser, David Chee-Guan Foo
Excessive lung water occurs when too much water accumulates in the lung, causing breathing difficulty. Current diagnosis methods include X-rays and CT-scans. However, because of their bulk and the need for trained professionals to operate, physicians rely on auscultation for preliminary diagnosis. Recent attempts have been made to automate the auscultation process and some degree of success has been reported. Thus, it would be useful to provide more analysis of such lung sounds. This paper attempts to study the characteristics of breathing sounds from lungs with excessive water and compare them with breathing sounds from healthy lungs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267682/a-retrospective-descriptive-comparative-study-to-identify-patient-variables-that-contribute-to-the-development-of-deep-tissue-injury-among-patients-in-intensive-care-units
#20
Holly Kirkland-Kyhn, Oleg Teleten, Machelle Wilson
Deep tissue injury (DTI) may develop in critically ill patients despite implementation of preventive interventions. A retrospective, descriptive study was conducted in a 620-bed, level 1 trauma, academic medical center with 7 adult intensive care units ([ICUs] cardiac surgery, trauma surgery, burn surgery, med-surgery, neurosurgery, medical, and transfer) among patients treated from January 1, 2010 to January 1, 2015. All patients 18 years of age or older that developed a sacral DTI that evolved into a Stage 3, Stage 4, or unstageable hospital-acquired pressure ulcers (HAPU) in the ICU were included...
February 2017: Ostomy/wound Management
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