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Homocysteine,menopause

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https://www.readbyqxmd.com/read/27300572/cardiovascular-risk-in-women-with-premature-ovarian-insufficiency-compared-to-premenopausal-women-at-middle-age
#1
Nadine M P Daan, Taulant Muka, Maria P H Koster, Jaenine E Roeters van Lennep, Cornelis B Lambalk, Joop S E Laven, Clemens G K M Fauser, Cindy Meun, Yolanda B de Rijke, Eric Boersma, Oscar H Franco, Maryam Kavousi, Bart C J M Fauser
CONTEXT: A young age at menopause has been associated with increased cardiovascular disease (CVD) risk. OBJECTIVE: To compare the cardiovascular risk profile between women with premature ovarian insufficiency (POI) and premenopausal controls of comparable age. DESIGN: Cross-sectional case control study. SETTING: Two university medical centers. PARTICIPANTS: Women above 45 years of age who were previously diagnosed with POI (n = 83) and premenopausal population controls of comparable age (n = 266)...
September 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26922199/relationship-of-homocysteine-levels-with-lumbar-spine-and-femur-neck-bmd-in-postmenopausal-women
#2
E Bahtiri, H Islami, S Rexhepi, H Qorraj-Bytyqi, K Thaçi, S Thaçi, C Karakulak, R Hoxha
OBJECTIVE: The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy), reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women. MATERIALS AND METHODS: One hundred thirty-nine postmenopausal women were recruited to enter this cross-sectional study...
October 2015: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/26758937/folic-acid-supplementation-reduces-plasma-homocysteine-in-postmenopausal-women
#3
Fariba Almassinokiani, Maryam Kashanian, Peyman Akbari, Elaheh Mossayebi, Elena Sadeghian
Plasma homocysteine, which is increased after menopause, can be a risk factor for cardiovascular disease and osteoporosis. The purpose of the present study was to determine the effect of folic acid supplementation on plasma homocysteine in postmenopausal women. The study was performed as a randomized placebo controlled trial on 48 healthy postmenopausal women (aged 50-70 years) and plasma homocysteine of all women was measured. In the case group, folic acid, and in the control group, placebo was prescribed...
May 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26304851/effects-of-strontium-ranelate-on-markers-of-cardiovascular-risk-in-postmenopausal-osteoporotic-women
#4
Marco Atteritano, Antonino Catalano, Domenico Santoro, Antonino Lasco, Salvatore Benvenga
Recent pooled analyses have shown that strontium ranelate increases the incidence of venous thromboembolism and non-fatal myocardial infarction, but no explanations were given. The aim of our study was to assess the effects a 12-month treatment with strontium ranelate on hemostasis factors and markers of cardiovascular risk in postmenopausal osteoporotic women. Forty osteoporotic postmenopausal women received orally strontium ranelate 2 g daily, plus calcium and colecalcipherol for 12 months. Forty postmenopausal osteopenic women matched for age, menopausal age, and body mass index served as controls and received orally calcium and colecalcipherol for 12 months...
July 2016: Endocrine
https://www.readbyqxmd.com/read/26267772/-benefits-of-moderate-beer-consumption-at-different-stages-of-life-of-women
#5
Tirso Pérez Medina, Nuria de Argila Fernández-Durán, Augusto Pereira Sánchez, Lucía Serrano González
Beer is a natural beverage low calorie, low degree of alcohol, no fats or sugars and a significant amount of carbohydrates, vitamins, and proteins. Beneficial health qualities are based on the presence in the beer of antioxidant compounds (polyphenols), which reduce the presence of free radicals in the organism, and phytoestrogens, elements biosimilars to natural estrogens. In pregnant women, beer, obviously alcohol-free, presents elements in its composition that differ it from other fermented beverages as it is the folic acid, vitamin necessary to prevent defects of the neural tube in the fetus or regulate homocysteine...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26267686/-association-of-metabolic-syndrome-with-serum-cystatin-c-in-people-undergoing-health-examination
#6
Yaqin Wang, Xia Cao, Pingting Yang, Ming Chen, Zhiheng Chen
OBJECTIVE: To investigate the relationship between metabolic syndrome (MetS) and cystatin C in people undergoing healthy examination.
 METHODS: A total of 6 783 subjects were analyzed. They were divided into MetS group (n=1 578), metabolic disturbance (MetD) group (n=3 617) and healthy control (HC) group (n=1 588). The general information, anthropometry, blood sample and urine sample were collected for all the subjects. Multiple logistic regression analysis was used to identify risk factors for MetS and analysis of covariance was used to investigate the correlation between the number of metabolic disturbance components and cystatin C...
July 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/25984918/relationship-of-homocysteine-levels-with-lumbar-spine-and-femur-neck-bmd-in-postmenopausal-women
#7
Elton Bahtiri, Hilmi Islami, Sylejman Rexhepi, Hasime Qorraj-Bytyqi, Kujtim Thaçi, Shpetim Thaçi, Çağla Karakulak, Rexhep Hoxha
OBJECTIVE: The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy), reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women. MATERIALS AND METHODS: One hundred thirty-nine postmenopausal women were recruited to enter this cross-sectional study...
May 18, 2015: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/25629018/the-association-between-oxidative-stress-and-bone-mineral-density-according-to-menopausal-status-of-korean-women
#8
Young Joo Lee, Ji Yun Hong, Seung Chul Kim, Jong Kil Joo, Yong Jin Na, Kyu Sup Lee
OBJECTIVE: The aim of this study is to investigate the association between oxidative stress and bone mineral density (BMD) according to menopausal status of Korean women. METHODS: A total of 2,232 women who visited to the health promotion center at Pusan National University Hospital between 2010 and 2014 were included in this cross-sectional study. Laboratory tests, such as uric acid, albumin, total bilirubin, which were evaluated as a natural antioxidants. Homocysteine also was evaluated as a factor associated with oxidative stress...
January 2015: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/25624861/the-association-between-the-844ins68-polymorphism-in-the-cbs-gene-and-breast-cancer
#9
Martha Patricia Gallegos-Arreola, Luis Eduardo Figuera-Villanueva, Adriana Ramos-Silva, Efraín Salas-González, Ana María Puebla-Pérez, Valeria Peralta-Leal, José Elías García-Ortiz, Ingrid Patricia Dávalos-Rodríguez, Guillermo Moisés Zúñiga-González
INTRODUCTION: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine. Polymorphisms of CBS have been associated with cancer. MATERIAL AND METHODS: We examined the role of the 844ins68 polymorphism by comparing the genotypes of 371 healthy Mexican women with the genotypes of 323 Mexican women with breast cancer (BC)...
December 22, 2014: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/25605419/17%C3%AE-estradiol-attenuates-homocysteine-induced-oxidative-stress-and-inflammatory-response-as-well-as-mapks-cascade-via-activating-pi3-k-akt-signal-transduction-pathway-in-raw-264-7-cells
#10
Ying Zhang, Ying He, Yi Zong, Jiazhi Guo, Lin Sun, Yunbing Ma, Wei Dong, Li Gui
Oxidative stress, inflammatory response, and mitogen-activated protein kinases (MAPKs) cascade are significant pathogenic factors of osteoporosis. It has been reported that elevated homocysteine (Hcy) may activate oxidative stress and reduce bone mineral density in post-menopausal osteoporosis. Moreover, hormone replacement therapy has been widely used in clinic to prevent and treat post-menopausal women with osteoporosis and osteoporotic fracture, but the molecular mechanisms and relevant signal transduction pathways underlying the action of Hcy remain unclear...
February 2015: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/25478337/prevalence-of-elevated-serum-homocysteine-and-serum-lipoprotein-a-in-women
#11
Alka N Sontakke, Mona A Tilak, Vaishali V Dhat, Umesh M More, Sarita A Shinde, Pradnya Phalak, Anita D Deshmukh
BACKGROUND: Recent studies indicate that the risk of coronary artery disease (CAD) in women is no less than that in men and menopausal women are equally vulnerable as men. Studies of recent risk factors like hyperhomocysteinemia and elevation in lipoprotein (a) reveal controversial role of the same. This study hence is an attempt to study the prevalence of these factors in women and their correlation with lipid profile. MATERIALS AND METHODS: Two hundred women were enrolled in the study- 100 premenopausal women (21-45y) and 100 menopausal (50-55y)...
October 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/24615362/lipid-and-non-lipid-cardiovascular-risk-factors-in-postmenopausal-type-2-diabetic-women-with-and-without-coronary-heart-disease
#12
COMPARATIVE STUDY
G T Russo, A Giandalia, E L Romeo, M Marotta, A Alibrandi, C De Francesco, K V Horvath, B Asztalos, D Cucinotta
BACKGROUND: Coronary heart disease (CHD) is the leading cause of death in diabetic women. In addition to hyperglycemia, other factors may contribute to the excessive cardiovascular risk. AIM: In this study we evaluated common and emerging risk factors in a selected group of postmenopausal type 2 diabetic women with (n = 36) and without CHD (n = 59), not taking lipid-lowering medications. METHODS: Clinical and lifestyle data were collected, and metabolic and lipid profile, as well as fasting plasma levels of total homocysteine (tHcy), folate, vitamin B12, C-reactive protein (hsCRP), interleukin 6 (IL-6), and vascular cell adhesion molecule-1 (VCAM-1) were measured in all participants...
March 2014: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/24395112/systemic-chemotherapy-interferes-in-homocysteine-metabolism-in-breast-cancer-patients
#13
Eliana K Yamashita, Bianca M Teixeira, Renata N Yoshihara, Renata K Kuniyoshi, Beatriz C A Alves, Flávia S Gehrke, Viviane A Vilas-Bôas, João A Correia, Ligia A Azzalis, Virginia B C Junqueira, Edimar Cristiano Pereira, Fernando L A Fonseca
BACKGROUND: Hyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data. METHODS: Thirty-five BC patients were included; blood samples were obtained by venipuncture. Plasmatic Hcy and cofactors concentrations were measured by competitive chemiluminescent enzyme immunoassay method...
March 2014: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/24113197/effect-of-raloxifene-on-disease-activity-and-vascular-biomarkers-in-patients-with-systemic-lupus-erythematosus-subgroup-analysis-of-a-double-blind-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
C C Mok, Shirley K Y Ying, K M Ma, C K Wong
OBJECTIVES: The purpose of this study was to identify the effect of raloxifene on disease activity and vascular biomarkers in patients with systemic lupus erythematosus (SLE). METHODS: Subgroup data were analyzed for postmenopausal female SLE patients who participated in a randomized controlled trial of raloxifene on glucocorticoid-induced osteoporosis. Patients who were receiving a stable daily dose of prednisolone (≤10 mg) for ≥6 months were assigned to receive raloxifene (60 mg/day) or placebo on top of calcium and vitamin D...
December 2013: Lupus
https://www.readbyqxmd.com/read/23845785/methionine-synthase-a2756g-polymorphism-and-breast-cancer-risk-an-up-to-date-meta-analysis
#15
Shanliang Zhong, Jinjin Xu, Wenjing Li, Zhiyuan Chen, Tengfei Ma, Jianhua Zhao
The methionine synthase (MTR) gene polymorphism A2756G has been linked to the risk of developing breast cancer, but the available results were inconsistent and underpowered. To derive a more precise estimation of the association between A2756G and breast cancer risk, an updated meta-analysis of 16 available studies with 9866 cases and 11,702 controls estimating the association between MTR A2756G and breast cancer risk was conducted. The quality of these studies was generally good except 2 studies with a lowest score 4 according to the Newcastle-Ottawa Scale (NOS)...
September 25, 2013: Gene
https://www.readbyqxmd.com/read/23828682/an-evaluation-of-nitric-oxide-folate-homocysteine-levels-and-lipid-peroxidation-in-postmenopausal-osteoporosis
#16
Veysi Akpolat, H Murat Bilgin, M Yusuf Celik, Mahmut Erdemoglu, Birgul Isik
OBJECTIVES: In the current study, the risk coefficients of nitric oxide (NO), folate, homocysteine levels and lipid peroxidation in postmenopausal osteoporotic women were determined. MATERIAL AND METHODS: Bone mineral density was determined by dual-energy X-ray absorptiometry. The levels of serum lipid peroxidation products such as the thiobarbituric acid adduct of malondialdehyde (MDA) were measured spectrophotometrically. Plasma folate and homocysteine (Hcy) levels were measured by enzyme chemiluminescence immunoassay...
May 2013: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/23686807/circulating-tumor-cell-detection-during-chemotherapy-in-patients-with-breast-cancer-is-not-associated-with-plasma-homocysteine-levels
#17
Renata Nunes Yoshihara, Bianca Marinelli Teixeira, Fernando Adami, Renata K Kuniyoshi, Beatriz C A Alves, Flávia S Gehrke, Viviane A Vilas-Bôas, Ligia A Azzalis, Virginia B C Junqueira, Edimar Cristiano Pereira, Fernando L A Fonseca
Breast cancer remains the second most frequent type of cancer in the world and the first among women, and systemic chemotherapy is an adjuvant therapeutic modality that improves survival in a great part of patients. Women with breast cancer, however, frequently show a higher risk of thromboembolism, an event associated to hyperhomocysteinemia and the presence of circulating tumor cells (CTC). Our aim is to correlate the presence of CTCs, detected by the analysis of CK19 and c-erbB2 gene expressions, and the homocysteine plasma levels in the peripheral blood in patients with breast cancer undergoing chemotherapy...
October 2013: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/23661876/intra-operative-grading-of-coronary-artery-atherosclerosis-associated-with-homocysteine-levels-in-postmenopausal-women-undergoing-elective-off-pump-cabg-surgery
#18
Seyed Jalil Mirhosseini, Seyed Khalil Forouzannia, Seyed Ali Mirhosseini, Sadegh Ali-Hassan-Sayegh, Mohammad Reza Mozayan
BACKGROUND: Atherosclerosis is one of the common causes of morbidity and mortality, in postmenopausal women. Homocysteine, a sulfur-containing amino acid product of methionine metabolism, may play an important role in the development of cardiovascular diseases. This study was designed to evaluate the relationship between intra-operative grading of coronary artery atherosclerosis and homocysteine level in postmenopausal women who were candidates for off-pump coronary bypass graft surgery (CABG)...
October 2012: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/23610979/hyperhomocysteinemia-and-methylenetetrahydrofolate-reductase-polymorphism-in-a-patient-with-coronary-artery-disease-and-repetitive-miscarriages
#19
Cristina Hoţoleanu, Eva Chouky
We report the case of a woman, aged 53 years, admitted for the assessment of angina; her history revealed 3 unexplained miscarriages, all in the first trimester of pregnancy. Based on clinical manifestations and complementary examinations, the patient was diagnosed with stable angina class functional II, according to The Canadian Cardiovascular Society Classification. The assessment of the risk factors shows a moderate hyperhomocysteinemia, due to methylenetetrahydrofolate reductase polymorphism (MTHFR C677T), abdominal obesity and post-menopausal status...
October 2012: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/23448998/endogenous-sex-hormones-and-their-associations-with-cardiovascular-risk-factors-in-post-menopausal-women
#20
N Güdücü, U Görmüş, S S Kutay, Z N Kavak, B Telatar
AIMS: Our aim was to understand the relationship between endogenous sex hormones and cardiovascular disease (CVD) risk factors in post-menopausal women. MATERIALS AND METHODS: Eighty-three post-menopausal women from a previous prospectively designed study were included. We analyzed endogenous sex hormones and biochemical parameters. RESULTS: Levels of estradiol and free testosterone were higher in patients with metabolic syndrome. Estradiol correlated positively with interleukin-6 (IL-6), weight, body mass index (BMI), insulin, homocysteine, and homeostasis model assessment of insulin resistance (HOMA-IR)...
September 2013: Journal of Endocrinological Investigation
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