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Galit Weinstein, Shira Zelber-Sagi, Sarah R Preis, Alexa S Beiser, Charles DeCarli, Elizabeth K Speliotes, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri
Importance: Nonalcoholic fatty liver disease (NAFLD) is a common condition that is most often asymptomatic. It is associated with metabolic syndrome, incident diabetes, carotid atherosclerosis, and endothelial dysfunction, conditions that in turn are strongly linked with brain damage and cognitive impairment. However, it is not known whether NAFLD is associated with structural brain measures in humans. Objective: To assess the association between prevalent NAFLD and brain magnetic resonance imaging (MRI) measures...
January 1, 2018: JAMA Neurology
Aswathy Vijayakumar, Eun-Kyung Kim, Hyesook Kim, Young Ju Choi, Kap Bum Huh, Namsoo Chang
BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily...
August 2017: Nutrition Research and Practice
Yi Jing, Danfeng Cai, Qi Chen, Qingping Xiong, Tianhui Hu, Yuan Yao, Chao Lin, Xin Sun, Ying Lu, Xueyun Kong, Xiang Wu, Yu Li, Huimin Bian
ETHNOPHARMACOLOGICAL RELEVANCE: Liuwei Dihuang (LWDH), a classical traditional Chinese medicine prescription, has been widely used to prevent and to treat various diseases with symptoms of 'Kidney-Yin' deficiency syndrome for over 1000 years in China. It is commonly used to treat functional decline associated with senile disease and menopausal syndrome, especially memory decline, insomnia, diabetes and osteoporosis. Modern experimental pharmacological studies indicated that the mechanism of LWDH treatment of menopausal syndrome may be associated with enhanced estrogenic effects...
July 12, 2017: Journal of Ethnopharmacology
Michelle C Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E Kissling, Sukhdev S Brar, Dorian Olivera, Chad Blystone, Greg Travlos
Black cohosh rhizome, available as a dietary supplement, is most commonly marketed as a remedy for dysmenorrhea and menopausal symptoms. A previous subchronic toxicity study of black cohosh dried ethanolic extract (BCE) in female mice revealed a dose-dependent ineffective erythropoiesis with a macrocytosis consistent with the condition known as megaloblastic anemia. The purpose of this study was to investigate potential mechanisms by which BCE induces these particular hematological changes. B6C3F1/N female mice (32/group) were exposed by gavage to vehicle or 1,000 mg/kg BCE for 92 days...
July 2017: Toxicologic Pathology
Neus Curcó, Nuria Barriendos, Maria José Barahona, Carmen Arteaga, Mercedes García, Stanislav Yordanov, Olimpia De La Barrera, Carolina Prat, Pere Vives, Nuria Giménez
BACKGROUND: Psoriasis has been associated with metabolic syndrome and with an increased cardiovascular risk especially in patients with severe disease. The goal of this study was to estimate the prevalence of metabolic syndrome and other cardiovascular risk factors and its association with the psoriasis severity, sex and age. METHODS: Consecutive patients with psoriasis were enrolled in a prospective study over a 1-year period. Blood samples were collected. Psoriasis area and severity index (PASI) and body surface area scores and two dermatology quality of life (DQOL) questionnaires were used to evaluate psoriasis severity and the impact of the disease...
February 27, 2017: Australasian Journal of Dermatology
Roberta Luzzi, Gianni Belcaro, Morio Hosoi, Beatrice Feragalli, Umberto Cornelli, Mark Dugall, Andrea Ledda
BACKGROUND: The aim of the study was the evaluation of the efficacy of Pycnogenol® in peri-menopausal women in controlling homocysteine and C-reactive protein (CRP) levels, borderline cardiovascular risk factors, oxidative stress (OS) and symptoms associated to menopausal transition (MT). METHODS: Pycnogenol®, 100mg/day, was used as a supplement for 8 weeks by a group of 35 women. A comparable group of 35 women with identical cardiovascular risk factors was included as the control group...
February 2017: Minerva Ginecologica
Jung Oh Kim, Soo Hong Han, Yeon Ho Lee, Tae Keun Ahn, Jae Joon Lim, Young Sun Chung, Dong Eun Shin, Woo Sik Lee, In Bo Han, Nam Keun Kim
Osteoporosis and osteoporotic fractures are strongly associated with mortality and morbidity, both in developing and developed countries. Menopause accelerates bone loss due to estrogen deficiency and age-related linear bone loss. We investigated plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in postmenopausal women with osteoporotic vertebral compression fractures (OVCFs). In this case-control study, 355 postmenopausal women were genotyped for the presence of PAI-1 gene polymorphisms -844A > G, -675 4G > 5G, 43G > A, 9785A > G, and 11053T > G...
December 9, 2016: International Journal of Molecular Sciences
Nadine M P Daan, Taulant Muka, Maria P H Koster, Jaenine E Roeters van Lennep, Cornelis B Lambalk, Joop S E Laven, Clemens G K M Fauser, Cindy Meun, Yolanda B de Rijke, Eric Boersma, Oscar H Franco, Maryam Kavousi, Bart C J M Fauser
CONTEXT: A young age at menopause has been associated with increased cardiovascular disease (CVD) risk. OBJECTIVE: To compare the cardiovascular risk profile between women with premature ovarian insufficiency (POI) and premenopausal controls of comparable age. DESIGN: Cross-sectional case control study. SETTING: Two university medical centers. PARTICIPANTS: Women above 45 years of age who were previously diagnosed with POI (n = 83) and premenopausal population controls of comparable age (n = 266)...
September 2016: Journal of Clinical Endocrinology and Metabolism
E Bahtiri, H Islami, S Rexhepi, H Qorraj-Bytyqi, K Thaçi, S Thaçi, C Karakulak, R Hoxha
OBJECTIVE: The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy), reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women. MATERIALS AND METHODS: One hundred thirty-nine postmenopausal women were recruited to enter this cross-sectional study...
October 2015: Acta Reumatológica Portuguesa
Fariba Almassinokiani, Maryam Kashanian, Peyman Akbari, Elaheh Mossayebi, Elena Sadeghian
Plasma homocysteine, which is increased after menopause, can be a risk factor for cardiovascular disease and osteoporosis. The purpose of the present study was to determine the effect of folic acid supplementation on plasma homocysteine in postmenopausal women. The study was performed as a randomized placebo controlled trial on 48 healthy postmenopausal women (aged 50-70 years) and plasma homocysteine of all women was measured. In the case group, folic acid, and in the control group, placebo was prescribed...
May 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Marco Atteritano, Antonino Catalano, Domenico Santoro, Antonino Lasco, Salvatore Benvenga
Recent pooled analyses have shown that strontium ranelate increases the incidence of venous thromboembolism and non-fatal myocardial infarction, but no explanations were given. The aim of our study was to assess the effects a 12-month treatment with strontium ranelate on hemostasis factors and markers of cardiovascular risk in postmenopausal osteoporotic women. Forty osteoporotic postmenopausal women received orally strontium ranelate 2 g daily, plus calcium and colecalcipherol for 12 months. Forty postmenopausal osteopenic women matched for age, menopausal age, and body mass index served as controls and received orally calcium and colecalcipherol for 12 months...
July 2016: Endocrine
Tirso Pérez Medina, Nuria de Argila Fernández-Durán, Augusto Pereira Sánchez, Lucía Serrano González
Beer is a natural beverage low calorie, low degree of alcohol, no fats or sugars and a significant amount of carbohydrates, vitamins, and proteins. Beneficial health qualities are based on the presence in the beer of antioxidant compounds (polyphenols), which reduce the presence of free radicals in the organism, and phytoestrogens, elements biosimilars to natural estrogens. In pregnant women, beer, obviously alcohol-free, presents elements in its composition that differ it from other fermented beverages as it is the folic acid, vitamin necessary to prevent defects of the neural tube in the fetus or regulate homocysteine...
July 18, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Yaqin Wang, Xia Cao, Pingting Yang, Ming Chen, Zhiheng Chen
OBJECTIVE: To investigate the relationship between metabolic syndrome (MetS) and cystatin C in people undergoing healthy examination.
 METHODS: A total of 6 783 subjects were analyzed. They were divided into MetS group (n=1 578), metabolic disturbance (MetD) group (n=3 617) and healthy control (HC) group (n=1 588). The general information, anthropometry, blood sample and urine sample were collected for all the subjects. Multiple logistic regression analysis was used to identify risk factors for MetS and analysis of covariance was used to investigate the correlation between the number of metabolic disturbance components and cystatin C...
July 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Elton Bahtiri, Hilmi Islami, Sylejman Rexhepi, Hasime Qorraj-Bytyqi, Kujtim Thaçi, Shpetim Thaçi, Çağla Karakulak, Rexhep Hoxha
OBJECTIVE: The focus of several studies in recent years has been the association between increased plasma concentrations of homocysteine (Hcy), reduced bone mineral density and increased risk of bone fractures. Nevertheless, inconsistencies persist in the literature. Thus, the objective of this study was to investigate the possible relationship between serum Hcy and vitamin B12 status, and bone mineral density, on a group of post-menopausal women. MATERIALS AND METHODS: One hundred thirty-nine postmenopausal women were recruited to enter this cross-sectional study...
May 18, 2015: Acta Reumatológica Portuguesa
Young Joo Lee, Ji Yun Hong, Seung Chul Kim, Jong Kil Joo, Yong Jin Na, Kyu Sup Lee
OBJECTIVE: The aim of this study is to investigate the association between oxidative stress and bone mineral density (BMD) according to menopausal status of Korean women. METHODS: A total of 2,232 women who visited to the health promotion center at Pusan National University Hospital between 2010 and 2014 were included in this cross-sectional study. Laboratory tests, such as uric acid, albumin, total bilirubin, which were evaluated as a natural antioxidants. Homocysteine also was evaluated as a factor associated with oxidative stress...
January 2015: Obstetrics & Gynecology Science
Martha Patricia Gallegos-Arreola, Luis Eduardo Figuera-Villanueva, Adriana Ramos-Silva, Efraín Salas-González, Ana María Puebla-Pérez, Valeria Peralta-Leal, José Elías García-Ortiz, Ingrid Patricia Dávalos-Rodríguez, Guillermo Moisés Zúñiga-González
INTRODUCTION: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine. Polymorphisms of CBS have been associated with cancer. MATERIAL AND METHODS: We examined the role of the 844ins68 polymorphism by comparing the genotypes of 371 healthy Mexican women with the genotypes of 323 Mexican women with breast cancer (BC)...
December 22, 2014: Archives of Medical Science: AMS
Ying Zhang, Ying He, Yi Zong, Jiazhi Guo, Lin Sun, Yunbing Ma, Wei Dong, Li Gui
Oxidative stress, inflammatory response, and mitogen-activated protein kinases (MAPKs) cascade are significant pathogenic factors of osteoporosis. It has been reported that elevated homocysteine (Hcy) may activate oxidative stress and reduce bone mineral density in post-menopausal osteoporosis. Moreover, hormone replacement therapy has been widely used in clinic to prevent and treat post-menopausal women with osteoporosis and osteoporotic fracture, but the molecular mechanisms and relevant signal transduction pathways underlying the action of Hcy remain unclear...
February 2015: Acta Biochimica et Biophysica Sinica
Alka N Sontakke, Mona A Tilak, Vaishali V Dhat, Umesh M More, Sarita A Shinde, Pradnya Phalak, Anita D Deshmukh
BACKGROUND: Recent studies indicate that the risk of coronary artery disease (CAD) in women is no less than that in men and menopausal women are equally vulnerable as men. Studies of recent risk factors like hyperhomocysteinemia and elevation in lipoprotein (a) reveal controversial role of the same. This study hence is an attempt to study the prevalence of these factors in women and their correlation with lipid profile. MATERIALS AND METHODS: Two hundred women were enrolled in the study- 100 premenopausal women (21-45y) and 100 menopausal (50-55y)...
October 2014: Journal of Clinical and Diagnostic Research: JCDR
G T Russo, A Giandalia, E L Romeo, M Marotta, A Alibrandi, C De Francesco, K V Horvath, B Asztalos, D Cucinotta
BACKGROUND: Coronary heart disease (CHD) is the leading cause of death in diabetic women. In addition to hyperglycemia, other factors may contribute to the excessive cardiovascular risk. AIM: In this study we evaluated common and emerging risk factors in a selected group of postmenopausal type 2 diabetic women with (n = 36) and without CHD (n = 59), not taking lipid-lowering medications. METHODS: Clinical and lifestyle data were collected, and metabolic and lipid profile, as well as fasting plasma levels of total homocysteine (tHcy), folate, vitamin B12, C-reactive protein (hsCRP), interleukin 6 (IL-6), and vascular cell adhesion molecule-1 (VCAM-1) were measured in all participants...
March 2014: Journal of Endocrinological Investigation
Eliana K Yamashita, Bianca M Teixeira, Renata N Yoshihara, Renata K Kuniyoshi, Beatriz C A Alves, Flávia S Gehrke, Viviane A Vilas-Bôas, João A Correia, Ligia A Azzalis, Virginia B C Junqueira, Edimar Cristiano Pereira, Fernando L A Fonseca
BACKGROUND: Hyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data. METHODS: Thirty-five BC patients were included; blood samples were obtained by venipuncture. Plasmatic Hcy and cofactors concentrations were measured by competitive chemiluminescent enzyme immunoassay method...
March 2014: Journal of Clinical Laboratory Analysis
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