Nikoletta Christoudia, Nikolaos Bekas, Eirini Kanata, Athanasia Chatziefsthathiou, Spyros Pettas, Korina Karagianni, Susana Margarida Da Silva Correia, Matthias Schmitz, Inga Zerr, Ioannis Tsamesidis, Konstantinos Xanthopoulos, Dimitra Dafou, Theodoros Sklaviadis
Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are characterized by the conformational conversion of the normal cellular prion protein, PrPC , into the pathogenic isoform, PrPSc . Prion diseases are invariably fatal and despite ongoing research, no effective prophylactic or therapeutic avenues are currently available. Anthocyanins (ACNs) are unique flavonoid compounds and interest in their use as potential neuroprotective and/or therapeutic agents against NDs, has increased significantly in recent years...
March 28, 2024: Redox Biology