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https://www.readbyqxmd.com/read/28092023/white-matter-alterations-in-college-football-players-a-longitudinal-diffusion-tensor-imaging-study
#1
Michael Christian Mayinger, Kian Merchant-Borna, Jakob Hufschmidt, Marc Muehlmann, Isabelle Ruth Weir, Boris-Stephan Rauchmann, Martha Elizabeth Shenton, Inga Katharina Koerte, Jeffrey John Bazarian
The aim of this study was to evaluate longitudinal changes in the diffusion characteristics of brain white matter (WM) in collegiate athletes at three time points: prior to the start of the football season (T1), after one season of football (T2), followed by six months of no-contact rest (T3). Fifteen male collegiate football players and 5 male non-athlete student controls underwent diffusion MR imaging and computerized cognitive testing at all three timepoints. Whole-brain tract-based spatial statistics (TBSS) were used to compare fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and trace between all timepoints...
January 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28062722/acute-plasma-tau-relates-to-prolonged-return-to-play-after-concussion
#2
Jessica Gill, Kian Merchant-Borna, Andreas Jeromin, Whitney Livingston, Jeffrey Bazarian
OBJECTIVE: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP...
January 6, 2017: Neurology
https://www.readbyqxmd.com/read/28050187/detection-of-borna-disease-virus-bdv-in-patients-with-first-episode-of-schizophrenia
#3
Hasan Soltani, Serwa Mohammadzadeh, Manoochehr Makvandi, Siroos Pakseresht, Alireza Samarbaf-Zadeh
Objective: Schizophrenia is a complex widespread neuropsychiatric disorder. This illness encompasses a complex debilitating mental disorder causing illusion, delusion, disturbed relationship, low motivation and decline of emotion. Viral infection of the brain including Borna Disease Virus (BDV) may play a role in transient or permanent neurological and behavioral abnormalities. This role of Borna virus has not been resolved outright yet, and based on published papers investigation examining the role of this virus in schizophrenia is in progress worldwide...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28035128/psychometric-properties-of-the-culig-s-questionnaire
#4
Aleksandar Momirovic, Mirela Ganza, Borna Culig, Marcel Leppee, Ivana Prga
BACKGROUND: Perseverance in applying the therapy is an important determinant of its success, but evaluation of perseverance is extremely complex, and therefore, alternative method of processing the results by the Culig's questionnaire of perseverance is presented. SUBJECTS AND METHOD: Psychometric properties of the questionnaire on a sample of 225 examinees have been calculated and the factor structure of indicators that make up the scale is presented. RESULTS: Psychometric properties calculated in an alternative way are significantly better than the original, especially when it comes to reliability and representativeness of the questionnaire...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/28027763/increased-interreader-agreement-in-diagnosis-of-hepatocellular-carcinoma-using-an-adapted-li-rads-algorithm
#5
Anton S Becker, Borna K Barth, Paulo H Marquez, Olivio F Donati, Erika J Ulbrich, Christoph Karlo, Cäcilia S Reiner, Michael A Fischer
PURPOSE: To evaluate a simplified Liver Imaging Reporting and Data System (LI-RADS) algorithm to improve interreader agreement while maintaining diagnostic performance for HCC. MATERIALS AND METHODS: MRI scans of 84 cirrhotic patients with 104 distinct liver observations were retrospectively selected to equivocally match each of the LI-RADS grades (LR1-5) using histopathology and imaging follow up as standard of reference. Four independent radiologists categorized all observations as benign (LR1-2) or potentially malignant (LR3-5) and determined LI-RADS based imaging features including observation size, arterial phase hyperenhancement, washout, capsule appearance and threshold growth for LR3-5 observations and timed their readouts...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27993642/the-effect-of-arsenite-on-spatial-learning-involvement-of-autophagy-and-apoptosis
#6
Behnoosh BonakdarYazdi, Fariba Khodagholi, Fatemeh Shaerzadeh, Azadeh Sharifzadeh, Ramesh Ahmadi, Mehdi Sanati, Hajar Mehdizadeh, Borna Payandehmehr, Leila Vali, Mehrnoush Moghaddasi Jahromi, Ghorban Taghizadeh, Mohammad Sharifzadeh
Spatial learning plays a major role in one's information recording. Arsenic is one of ubiquitous environmental toxins with known neurological effects. However, studies investigating the effects of arsenic on spatial learning and related mechanisms are limited. This study was planned toexaminethe effects of bilateral intra-hippocampal infusion of different concentrations of sodium arsenite (5, 10 and 100nM, 5µl/side) on spatial learning in Wistar rats. Moreover, we evaluated levels of LC3-II, Atg7 and Atg12 as reliable biomarkers of autophagy and caspase-3 and Bax/Bcl-2 ratio as indicators of apoptosis in the hippocampus...
December 18, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27927775/memantine-induced-chorea-and-dystonia
#7
Letizia Goncalves Borges, Borna Bonakdarpour
Memantine is an uncompetitive N-methyl-d-aspartate receptor antagonist and probably also has an indirect dopaminergic action at high concentrations. We describe a person with Alzheimer's disease who developed chorea and dystonia after inadvertently doubling of her daily dose by taking extended-release (XR) memantine twice daily, rather than once daily (planned dose memantine XR, 21 mg once daily), after the drug was switched from immediate release (IR, 10 mg twice daily). Memantine is rarely associated with movement disorders, but this case emphasises the need for awareness of potential problems when switching from memantine IR to XR...
December 7, 2016: Practical Neurology
https://www.readbyqxmd.com/read/27902378/neuronal-retrograde-transport-of-borna-disease-virus-occurs-in-signalling-endosomes
#8
Caroline M Charlier, Solène Debaisieux, Charlotte Foret, Anne Thouard, Giampietro Schiavo, Daniel Gonzalez-Dunia, Cécile E Malnou
Long-range axonal retrograde transport is a key mechanism for the cellular dissemination of neuroinvasive viruses, such as Borna disease virus (BDV), for which entry and egress sites are usually distant from the nucleus, where viral replication takes place. Although BDV is known to disseminate very efficiently in neurons, both in vivo and in primary cultures, the modalities of its axonal transport are still poorly characterized. In this work, we combined different methodological approaches, such as confocal microscopy and biochemical purification of endosomes, to study BDV retrograde transport...
December 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27878262/identification-of-suitable-reference-genes-for-bdv-infected-primary-rat-hippocampal-neurons
#9
Qiang Mao, Lujun Zhang, Yujie Guo, Lu Sun, Siwen Liu, Peng He, Rongzhong Huang, Lin Sun, Shigang Chen, Hong Zhang, Peng Xie
Borna disease virus (BDV) is a neurotropic RNA virus that infects the limbic system of mammals and results in behavioral disorders. The hippocampus is a core region in the limbic system, which contributes to memory and learning and is important in the regulation of emotion. However, no validated microRNA housekeeping genes have yet been identified in BDV‑infected rat primary hippocampal neurons. Proper normalization is key in accurate miRNA expression analysis. The present study used reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) to evaluate the expression stability of 10 commonly used reference genes [miR‑92a, 5S, U6, miR‑103, miR‑101a, miR-let-7a, miR‑16, E2 small nucleolar RNA (snoRNA), U87 and miR‑191] in BDV‑infected rat hippocampal neurons and non‑infected controls across 12 days post‑infection...
December 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27842550/change-in-the-responsiveness-of-interferon-stimulated-genes-during-early-pregnancy-in-cows-with-borna-virus-1-infection
#10
Tadashi Takino, Taku Okamura, Tatsuya Ando, Katsuro Hagiwara
BACKGROUND: Borna disease virus is a neurotropic pathogen and infects the central nervous system. This virus infected a variety of animal species including cows. The most of cows infected with Borna disease virus 1 (BoDV-1) exhibit subclinical infection without any neurological symptoms throughout their lifetime. We previously reported on the low conception rates in-seropositive cows. Interferon-τ (IFN-τ) plays an important role in stable fertilization, and is produced from the fetal side following embryo growth at 15-40 days of pregnancy...
November 14, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27809822/primary-psychosis-and-borna-disease-virus-infection-in-lithuania-a-case-control-study
#11
Violeta Zaliunaite, Vesta Steibliene, Liv Bode, Aurelija Podlipskyte, Robertas Bunevicius, Hanns Ludwig
BACKGROUND: The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conformities in detection methods. BDV circulating immune complexes (CIC) were shown to exceed the prevalence of serum antibodies alone and to comparably screen for infection in Europe (DE, CZ, IT), the Middle East (IR) and Asia (CN), still seeking general acceptance. METHODS: We used CIC and antigen (Ag) tests to investigate BDV infection in Lithuania through a case-control study design comparing in-patients suffering of primary psychosis with blood donors...
November 3, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27803166/borna-disease-virus-assembles-porous-cage-like-viral-factories-in-the-nucleus
#12
Yuya Hirai, Yasuhiro Hirano, Atsushi Matsuda, Yasushi Hiraoka, Tomoyuki Honda, Keizo Tomonaga
Animal-derived RNA viruses frequently generate viral factories in infected cells. However, the details of how RNA viruses build such intracellular structures are poorly understood. In this study, we examined the structure and formation of the viral factories, called viral speckle of transcripts (vSPOTs), that are produced in the nuclei of host cells by Borna disease virus (BDV). Super-resolution microscopic analysis showed that BDV assembled vSPOTs as intranuclear cage-like structures with 59-180-nm pores. The viral nucleoprotein formed the exoskeletons of vSPOTs, whereas the other viral proteins appeared to be mainly localized within these structures...
December 9, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27795475/detection-of-antibodies-to-borna-disease-virus-proteins-in-an-autistic-child-and-her-mother
#13
Tomoyuki Honda, Kozue Sofuku, Hidenori Matsunaga, Masaya Tachibana, Ikuko Mohri, Masako Taniike, Keizo Tomonaga
No abstract text is available yet for this article.
October 31, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27793113/pre-induction-translabial-ultrasound-measurements-in-predicting-mode-of-delivery-compared-to-bishop-score-a-cross-sectional-study
#14
Soghra Khazardoost, Fahimeh Ghotbizadeh Vahdani, Sahar Latifi, Sedighe Borna, Maryam Tahani, Mohammad Ali Rezaei, Masoomeh Shafaat
BACKGROUND: By increased concerns about the accuracy of the traditional methods to predict outcomes after induction of labor, developing new standards has a great clinical importance. Here, we compared the predictive value of translabial ultrasound measurements with Bishop Score to determine the suitability of induction of labor. METHODS: A homogenous population of primigravid women was recruited. Induction of labor was performed with low-dose infusion of oxytocin...
October 28, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27790096/intranasal-location-and-immunohistochemical-characterization-of-the-equine-olfactory-epithelium
#15
Alexandra Kupke, Sabine Wenisch, Klaus Failing, Christiane Herden
The olfactory epithelium (OE) is the only body site where neurons contact directly the environment and are therefore exposed to a broad variation of substances and insults. It can serve as portal of entry for neurotropic viruses which spread via the olfactory pathway to the central nervous system. For horses, it has been proposed and concluded mainly from rodent studies that different viruses, e.g., Borna disease virus, equine herpesvirus 1 (EHV-1), hendra virus, influenza virus, rabies virus, vesicular stomatitis virus can use this route...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27776645/simultaneous-multi-slice-echo-planar-diffusion-weighted-imaging-of-the-liver-and-the-pancreas-optimization-of-signal-to-noise-ratio-and-acquisition-time-and-application-to-intravoxel-incoherent-motion-analysis
#16
Andreas Boss, Borna Barth, Lukas Filli, David Kenkel, Moritz C Wurnig, Marco Piccirelli, Caecilia S Reiner
PURPOSE: To optimize and test a diffusion-weighted imaging (DWI) echo-planar imaging (EPI) sequence with simultaneous multi-slice (SMS) excitation in the liver and pancreas regarding acquisition time (TA), number of slices, signal-to-noise ratio (SNR), image quality (IQ), apparent diffusion coefficient (ADC) quantitation accuracy, and feasibility of intravoxel incoherent motion (IVIM) analysis. MATERIALS AND METHODS: Ten healthy volunteers underwent DWI of the upper abdomen at 3T...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27748825/identification-and-bioinformatic-analysis-of-dysregulated-micrornas-in-human-oligodendroglial-cells-infected-with-borna-disease-virus
#17
Hong Zhang, Peng He, Rongzhong Huang, Lin Sun, Siwen Liu, Jingjing Zhou, Yujie Guo, Deyu Yang, Peng Xie
MicroRNAs (miRNAs) are recognized as important regulators of gene expression via translational depression or mRNA degradation. Previously, dysregulated miRNAs have been found in neurodegenerative and neuropsychiatric disorders. Borna disease virus (BDV) is a neurotropic, negative single‑stranded RNA virus, which may be a cause of human neuropsychiatric disease. BDV is regarded as an ideal model to analyze the molecular mechanisms of mental disorders caused by viral infection. In the present study, 10 miRNAs were dysregulated in human oligodendrocytes (OL cells) infected with the BDV strain, Hu‑H1 (OL/BDV)...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27745899/phagocytizing-activity-of-pmn-from-severe-trauma-patients-in-different-post-traumatic-phases-during-the-10-days-post-injury-course
#18
Ramona Sturm, David Heftrig, Katharina Mörs, Nils Wagner, Kerstin Kontradowitz, Katrin Jurida, Ingo Marzi, Borna Relja
OBJECTIVE: Phagocytizing leukocytes (granulocytes and monocytes) play a fundamental role in immunological defense against pathogens and clearance of cellular debris after tissue injury due to trauma. According to the "two-hit hypothesis", phagocytes become primed due to/after trauma. Subsequently, a secondary stimulus may lead to their exaggerated response. This immune dysfunction can result in serious infectious complications, also depending on trauma injury pattern. Here, we investigated the phagocytizing capacity of leukocytes, and its correlation to trauma injury pattern...
February 2017: Immunobiology
https://www.readbyqxmd.com/read/27672855/poster-87-post-infectious-cerebellar-ataxia-in-a-young-male-a%C3%A2-case-report
#19
Borna Kavousi, Nicholas Giordano, Matthew Hadilaksono, Margarita Nunez
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27662771/dose-optimized-computed-tomography-for-screening-and-follow-up-of-solid-pulmonary-nodules-in-obesity-a-phantom-study
#20
Katharina Martini, Borna K Barth, Kai Higashigaito, Stephan Baumueller, Hatem Alkadhi, Thomas Frauenfelder
To determine the lowest CT radiation dose-level at maintained image-quality and high sensitivity for detection of pulmonary-nodules in obesity. Single-energy CT with tin-filtration was performed in a chest-phantom with solid pulmonary-nodules simulating over-weight and obesity. CTDIvol of the standard-protocol was 0.41 mGy, subsequent scans were obtained at 1/2 and 1/4 dose-levels. Images were reconstructed using FBP and advanced-modeled iterative reconstruction (ADMIRE). Noise, image-quality, and sensitivity for nodule-detection were assessed...
August 2, 2016: Current Problems in Diagnostic Radiology
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