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https://www.readbyqxmd.com/read/27902378/neuronal-retrograde-transport-of-borna-disease-virus-occurs-in-signaling-endosomes
#1
Caroline M Charlier, Solène Debaisieux, Charlotte Foret, Anne Thouard, Giampetro Schiavo, Daniel Gonzalez-Dunia, Cécile Evelyne Malnou
Long-range axonal retrograde transport is a key mechanism for the cellular dissemination of neuro-invasive viruses, such as Borna Disease Virus (BDV), for which entry and egress sites are usually distant from the nucleus, where viral replication takes place. Although BDV is known to disseminate very efficiently in neurons, both in vivo and in primary cultures, the modalities of its axonal transport are still poorly characterized. In this work, we combined different methodological approaches, such as confocal microscopy and biochemical purification of endosomes, to study BDV retrograde transport...
November 8, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27878262/identification-of-suitable-reference-genes-for-bdv-infected-primary-rat-hippocampal-neurons
#2
Qiang Mao, Lujun Zhang, Yujie Guo, Lu Sun, Siwen Liu, Peng He, Rongzhong Huang, Lin Sun, Shigang Chen, Hong Zhang, Peng Xie
Borna disease virus (BDV) is a neurotropic RNA virus that infects the limbic system of mammals and results in behavioral disorders. The hippocampus is a core region in the limbic system, which contributes to memory and learning and is important in the regulation of emotion. However, no validated microRNA housekeeping genes have yet been identified in BDV‑infected rat primary hippocampal neurons. Proper normalization is key in accurate miRNA expression analysis. The present study used reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) to evaluate the expression stability of 10 commonly used reference genes [miR‑92a, 5S, U6, miR‑103, miR‑101a, miR-let-7a, miR‑16, E2 small nucleolar RNA (snoRNA), U87 and miR‑191] in BDV‑infected rat hippocampal neurons and non‑infected controls across 12 days post‑infection...
November 22, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27842550/change-in-the-responsiveness-of-interferon-stimulated-genes-during-early-pregnancy-in-cows-with-borna-virus-1-infection
#3
Tadashi Takino, Taku Okamura, Tatsuya Ando, Katsuro Hagiwara
BACKGROUND: Borna disease virus is a neurotropic pathogen and infects the central nervous system. This virus infected a variety of animal species including cows. The most of cows infected with Borna disease virus 1 (BoDV-1) exhibit subclinical infection without any neurological symptoms throughout their lifetime. We previously reported on the low conception rates in-seropositive cows. Interferon-τ (IFN-τ) plays an important role in stable fertilization, and is produced from the fetal side following embryo growth at 15-40 days of pregnancy...
November 14, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27809822/primary-psychosis-and-borna-disease-virus-infection-in-lithuania-a-case-control-study
#4
Violeta Zaliunaite, Vesta Steibliene, Liv Bode, Aurelija Podlipskyte, Robertas Bunevicius, Hanns Ludwig
BACKGROUND: The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conformities in detection methods. BDV circulating immune complexes (CIC) were shown to exceed the prevalence of serum antibodies alone and to comparably screen for infection in Europe (DE, CZ, IT), the Middle East (IR) and Asia (CN), still seeking general acceptance. METHODS: We used CIC and antigen (Ag) tests to investigate BDV infection in Lithuania through a case-control study design comparing in-patients suffering of primary psychosis with blood donors...
November 3, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27803166/borna-disease-virus-assembles-porous-cage-like-viral-factories-in-the-nucleus
#5
Yuya Hirai, Yasuhiro Hirano, Atsushi Matsuda, Yasushi Hiraoka, Tomoyuki Honda, Keizo Tomonaga
Animal-derived RNA viruses frequently generate viral factories in infected cells. However, the details of how RNA viruses build such intracellular structures are poorly understood. In this study, we examined the structure and formation of the viral factories, called viral speckle of transcripts (vSPOTs), that are produced in the nuclei of host cells by Borna disease virus (BDV). Super-resolution microscopic analysis showed that BDV assembled vSPOTs as intranuclear cage-like structures with 59-180-nm pores. The viral nucleoprotein formed the exoskeletons of vSPOTs, whereas the other viral proteins appeared to be mainly localized within these structures...
November 1, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27795475/detection-of-antibodies-to-borna-disease-virus-proteins-in-an-autistic-child-and-her-mother
#6
Tomoyuki Honda, Kozue Sofuku, Hidenori Matsunaga, Masaya Tachibana, Ikuko Mohri, Masako Taniike, Keizo Tomonaga
No abstract text is available yet for this article.
October 31, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27793113/pre-induction-translabial-ultrasound-measurements-in-predicting-mode-of-delivery-compared-to-bishop-score-a-cross-sectional-study
#7
Soghra Khazardoost, Fahimeh Ghotbizadeh Vahdani, Sahar Latifi, Sedighe Borna, Maryam Tahani, Mohammad Ali Rezaei, Masoomeh Shafaat
BACKGROUND: By increased concerns about the accuracy of the traditional methods to predict outcomes after induction of labor, developing new standards has a great clinical importance. Here, we compared the predictive value of translabial ultrasound measurements with Bishop Score to determine the suitability of induction of labor. METHODS: A homogenous population of primigravid women was recruited. Induction of labor was performed with low-dose infusion of oxytocin...
October 28, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27790096/intranasal-location-and-immunohistochemical-characterization-of-the-equine-olfactory-epithelium
#8
Alexandra Kupke, Sabine Wenisch, Klaus Failing, Christiane Herden
The olfactory epithelium (OE) is the only body site where neurons contact directly the environment and are therefore exposed to a broad variation of substances and insults. It can serve as portal of entry for neurotropic viruses which spread via the olfactory pathway to the central nervous system. For horses, it has been proposed and concluded mainly from rodent studies that different viruses, e.g., Borna disease virus, equine herpesvirus 1 (EHV-1), hendra virus, influenza virus, rabies virus, vesicular stomatitis virus can use this route...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27776645/simultaneous-multi-slice-echo-planar-diffusion-weighted-imaging-of-the-liver-and-the-pancreas-optimization-of-signal-to-noise-ratio-and-acquisition-time-and-application-to-intravoxel-incoherent-motion-analysis
#9
Andreas Boss, Borna Barth, Lukas Filli, David Kenkel, Moritz C Wurnig, Marco Piccirelli, Caecilia S Reiner
PURPOSE: To optimize and test a diffusion-weighted imaging (DWI) echo-planar imaging (EPI) sequence with simultaneous multi-slice (SMS) excitation in the liver and pancreas regarding acquisition time (TA), number of slices, signal-to-noise ratio (SNR), image quality (IQ), apparent diffusion coefficient (ADC) quantitation accuracy, and feasibility of intravoxel incoherent motion (IVIM) analysis. MATERIALS AND METHODS: Ten healthy volunteers underwent DWI of the upper abdomen at 3T...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27748825/identification-and-bioinformatic-analysis-of-dysregulated-micrornas-in-human-oligodendroglial-cells-infected-with-borna-disease-virus
#10
Hong Zhang, Peng He, Rongzhong Huang, Lin Sun, Siwen Liu, Jingjing Zhou, Yujie Guo, Deyu Yang, Peng Xie
MicroRNAs (miRNAs) are recognized as important regulators of gene expression via translational depression or mRNA degradation. Previously, dysregulated miRNAs have been found in neurodegenerative and neuropsychiatric disorders. Borna disease virus (BDV) is a neurotropic, negative single‑stranded RNA virus, which may be a cause of human neuropsychiatric disease. BDV is regarded as an ideal model to analyze the molecular mechanisms of mental disorders caused by viral infection. In the present study, 10 miRNAs were dysregulated in human oligodendrocytes (OL cells) infected with the BDV strain, Hu‑H1 (OL/BDV)...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27745899/phagocytizing-activity-of-pmn-from-severe-trauma-patients-in-different-post-traumatic-phases-during-the-10-days-post-injury-course
#11
Ramona Sturm, David Heftrig, Katharina Mörs, Nils Wagner, Kerstin Kontradowitz, Katrin Jurida, Ingo Marzi, Borna Relja
OBJECTIVE: Phagocytizing leukocytes (granulocytes and monocytes) play a fundamental role in immunological defense against pathogens and clearance of cellular debris after tissue injury due to trauma. According to the "two-hit hypothesis", phagocytes become primed due to/after trauma. Subsequently, a secondary stimulus may lead to their exaggerated response. This immune dysfunction can result in serious infectious complications, also depending on trauma injury pattern. Here, we investigated the phagocytizing capacity of leukocytes, and its correlation to trauma injury pattern...
September 29, 2016: Immunobiology
https://www.readbyqxmd.com/read/27672855/poster-87-post-infectious-cerebellar-ataxia-in-a-young-male-a%C3%A2-case-report
#12
Borna Kavousi, Nicholas Giordano, Matthew Hadilaksono, Margarita Nunez
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27662771/dose-optimized-computed-tomography-for-screening-and-follow-up-of-solid-pulmonary-nodules-in-obesity-a-phantom-study
#13
Katharina Martini, Borna K Barth, Kai Higashigaito, Stephan Baumueller, Hatem Alkadhi, Thomas Frauenfelder
To determine the lowest CT radiation dose-level at maintained image-quality and high sensitivity for detection of pulmonary-nodules in obesity. Single-energy CT with tin-filtration was performed in a chest-phantom with solid pulmonary-nodules simulating over-weight and obesity. CTDIvol of the standard-protocol was 0.41 mGy, subsequent scans were obtained at 1/2 and 1/4 dose-levels. Images were reconstructed using FBP and advanced-modeled iterative reconstruction (ADMIRE). Noise, image-quality, and sensitivity for nodule-detection were assessed...
August 2, 2016: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/27662577/simultaneous-multislice-diffusion-weighted-imaging-of-the-kidney-a-systematic-analysis-of-image-quality
#14
David Kenkel, Borna K Barth, Marco Piccirelli, Lukas Filli, Tim Finkenstädt, Cäcilia S Reiner, Andreas Boss
OBJECTIVES: The aims of this study were to implement a protocol for simultaneous multislice (SMS) accelerated diffusion-weighted imaging (DWI) of the kidneys and to perform a systematic analysis of image quality of the data sets. MATERIALS AND METHODS: Ten healthy subjects and 5 patients with renal masses underwent DWI of the kidney in this prospective institutional review board-approved study on a 3 T magnetic resonance scanner. Simultaneous multislice DWI echo-planar sequences (acceleration factors [AFs] 2 and 3) were compared with conventional echo-planar DWI as reference standard for each acquisition scheme...
September 22, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27647509/ep16-16-relationship-between-amniotic-fluid-and-maternal-lipid-profiles-for-predicting-pregnancy-outcome
#15
S Borna
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27590473/screening-red-foxes-vulpes-vulpes-for-possible-viral-causes-of-encephalitis
#16
Manon Bourg, Daniel Nobach, Sibylle Herzog, Hildburg Lange-Herbst, Anne Nesseler, Hans-Peter Hamann, Sabrina Becker, Dirk Höper, Bernd Hoffmann, Markus Eickmann, Christiane Herden
BACKGROUND: Next to various known infectious and non-infectious causes, the aetiology of non-suppurative encephalitis in red foxes (Vulpes vulpes) often remains unclear. Known causes in foxes imply rabies, canine distemper, toxoplasmosis, Aujeszky's disease, as well as parvovirus, adenovirus, circovirus and flavivirus infections. In this study, particular attention was paid on bornaviruses, since red foxes are predators of bicoloured white-toothed shrews, a reservoir of Borna disease virus 1 (BoDV-1)...
2016: Virology Journal
https://www.readbyqxmd.com/read/27510928/endogenous-non-retroviral-rna-virus-elements-evidence-a-novel-type-of-antiviral-immunity
#17
COMMENT
Tomoyuki Honda, Keizo Tomonaga
Vertebrate genomes contain many virus-related sequences derived from both retroviruses and non-retroviral RNA and DNA viruses. Such non-retroviral RNA sequences are possibly produced by reverse-transcription and integration of viral mRNAs of ancient RNA viruses using retrotransposon machineries. We refer to this process as transcript reversion. During an ancient bornavirus infection, transcript reversion may have left bornavirus-related sequences, known as endogenous bornavirus-like nucleoproteins (EBLNs), in the genome...
May 2016: Mobile Genetic Elements
https://www.readbyqxmd.com/read/27498995/sero-epidemiological-analysis-of-vertical-transmission-relative-risk-of-borna-disease-virus-infection-in-dairy-herds
#18
Tatsuya Ando, Tadashi Takino, Kohei Makita, Motoshi Tajima, Masateru Koiwa, Katsuro Hagiwara
Borna disease virus (BDV) is a virus that causes a neurological disease in domestic animals, including a variety of animal species in Japan. Few studies have examined the mode of transmission of this virus in cattle, and the exact mechanisms underlying the transmission of the virus need to be elucidated. This study aimed to examine the contribution of vertical transmission of the virus, which occurs when the virus is transmitted from the mother to offspring during gestation or birth. We used an epidemiological approach...
December 1, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27496722/cambridge-polytrauma-pathway-are-we-making-appropriately-guided-decisions
#19
William Wynell-Mayow, Borna Guevel, Benjamin Quansah, Ronan O'Leary, Andrew D Carrothers
Addenbrooke's Hospital, the Major Trauma Centre for the East of England Trauma Network, received 1070 major trauma patients between 1st January and 31st December 2014. In order to improve care, an audit was performed of 59 patients meeting our own selection criteria for orthopaedic polytrauma between 1st January 2013 and 31st December 2013. The Cambridge Polytrauma Pathway was devised through NCEPOD guidelines, literature review, internal and external discussion. It facilitates provision of best practice Early Appropriate Care, encompassing - multidisciplinary consultant decisions around the patient in our Neurological and Trauma Critical Care Unit, early full body trauma CT scans, serial measurements of lactate and fibrinogen levels, and out-of-hours orthopaedic theatre reserved for life-and-limb threatening injuries...
October 2016: Injury
https://www.readbyqxmd.com/read/27486031/diagnostic-accuracy-of-individual-antenatal-tools-for-the-detection-of-the-small-for-gestational-age-newborn
#20
Borna Poljak, Umber Agarwal, Richard Jackson, Zarko Alfirevic, Andrew Sharp
OBJECTIVE: To define the accuracy of fetal and newborn growth charts for the detection of small for gestational age (SGA) fetuses (<10(th) centile). METHODS: This study was a prospective cohort study performed within a UK specialist fetal growth clinic. 105 consecutive pregnant women referred with a fetus suspected of being SGA. All pregnancies were managed according to a standard protocol using estimated fetal weight (EFW) plotted on customised GROW charts. Last antenatal estimate of EFW (GROW, Mikolayczyk), abdominal circumference (AC Hadlock, Ig-21, AC Chitty) or change in AC over time (POP study) was compared to 4 birthweight charts (GROW, Ig-21, Mikolayczyk, WHO) and to APO...
August 3, 2016: Ultrasound in Obstetrics & Gynecology
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