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https://www.readbyqxmd.com/read/28526153/pharmacology-of-octreotide-clinical-implications-for-anesthesiologists-and-associated-risks
#1
REVIEW
Reza M Borna, Jonathan S Jahr, Susanna Kmiecik, Ken F Mancuso, Alan D Kaye
Many patients presenting with a history of foregut, midgut neuroendocrine tumors (NETs) or carcinoid syndrome can experience life-threatening carcinoid crises during anesthesia or surgery. Clinicians should understand the pharmacology of octreotide and appreciate the use of continuous infusions of high-dose octreotide, which can minimize intraoperative carcinoid crises. We administer a prophylactic 500-μg bolus of octreotide intravenously (IV) and begin a continuous infusion of 500 μg/h for all NET patients...
June 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28512492/in-vitro-sealing-properties-of-calcium-enriched-mixture-and-mineral-trioxide-aggregate-orifice-barriers-during-intra-coronal-bleaching
#2
Negar Moghadam, Amir Ardalan Abdollahi, Hoda Aghabalayi Fakhim, Zahra Borna
INTRODUCTION: This study aimed at evaluating the sealing properties of calcium-enriched mixture (CEM) compared to mineral trioxide aggregate (MTA) as a cervical barriers in intra-coronal bleaching. METHODS AND MATERIALS: In this in vitro study, endodontic treatment was performed on 60 extracted human incisors and canines without canal calcification, caries, restorations, resorption or cracks. The teeth were then randomly divided into two experimental groups and two control groups (n=15)...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28503288/geographical-mortality-distribution-of-cardiovascular-diseases-first-report-from-south-khorasan-iran
#3
Toba Kazemi, Gholamreza Sharifzadeh, Nahid Borna
No abstract text is available yet for this article.
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28493974/serum-%C3%AE-1-antitrypsin-aat-antagonizes-intrinsic-apoptosis-induction-in-neutrophils-from-patients-with-systemic-inflammatory-response-syndrome
#4
Theresia Sarabhai, Christoph Peter, Anne-Kathrin Bär, Joachim Windolf, Borna Relja, Sebastian Wesselborg, Thorsten Wahlers, Adnana Paunel-Görgülü
Excessive neutrophil activation accompanied by delayed apoptotic cell death in inflammatory conditions causes progressive damage of cells and tissues, leading to life-threatening multiple organ dysfunction syndrome. Previous work suggested that circulating serum factors during inflammation are critically involved in the suppression of neutrophil cell death although the identity of these antiapoptotic mediators remained elusive. In this study, we identified the acute phase protein α-1 Antitrypsin (AAT) as a potent suppressor of staurosporine (STS)-induced apoptosis in human neutrophils through a mechanism implicating caspases-independent pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28485935/azaborininones-synthesis-and-structural-analysis-of-a-carbonyl-containing-class-of-azaborines
#5
Geraint H M Davies, Asma Mukhtar, Borna Saeednia, Fatemeh Sherafat, Christopher B Kelly, Gary A Molander
An approach to access azaborininones (carbonyl-containing, boron-based heterocyclic scaffolds) using simple reagents and conditions from both organotrifluoroborates and boronic acids is described. An inexpensive, common reagent, SiO2, was found to serve as both a fluorophile and desiccant to facilitate the annulation process across three different azaborininone platforms. Computational analysis of some of the cores synthesized in this study was undertaken to compare the azaborininones with the analogous carbon-based heterocyclic systems...
May 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28480413/presence-of-citrinin-in-grains-and-its-possible-health-effects
#6
Borna Čulig, Martina Bevardi, Jasna Bošnir, Sonja Serdar, Dario Lasić, Aleksandar Racz, Antonija Galić, Željka Kuharić
BACKGROUND: Citrinin is a mycotoxin produced by several species of the genera Aspergillus, Penicillium and Monascus and it occurs mainly in stored grain. Citrinin is generally formed after harvest and occurs mainly in stored grains, it also occurs in other plant products. Often, the co-occurrence with other mycotoxins is observed, especially ochratoxin A, which is usually associated with endemic nephropathy. At the European Union level, systematic monitoring of Citrinin in grains began with the aim of determining its highest permissible amount in food...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28465146/antiviral-activity-of-favipiravir-t-705-against-mammalian-and-avian-bornaviruses
#7
Tomoya Tokunaga, Yusuke Yamamoto, Madoka Sakai, Keizo Tomonaga, Tomoyuki Honda
Bornaviruses, non-segmented, negative-strand RNA viruses, are emerging agents with the potential for causing various types of neurological symptoms. Previous studies have shown that ribavirin, a nucleic acid analog with broad-spectrum antiviral activity, has a potent antiviral effect on infections with a mammalian bornavirus, Borna disease virus (BoDV-1), as well as avian bornaviruses. However, ribavirin-based treatment does not eliminate bornaviruses from persistently infected cells and viral replication resumes after treatment cessation...
April 29, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28446679/central-nervous-system-infection-with-borna-disease-virus-causes-kynurenine-pathway-dysregulation-and-neurotoxic-quinolinic-acid-production
#8
Simone Formisano, Mady Hornig, Kavitha Yaddanapudi, Mansi Vasishtha, Loren H Parsons, Thomas Briese, W Ian Lipkin, Brent L Williams
Central nervous system infection of neonatal and adult rats with Borna disease virus (BDV) results in neuronal destruction and behavioral abnormalities with differential immune-mediated involvement. Neuroactive metabolites generated from the kynurenine pathway of tryptophan degradation have been implicated in several human neurodegenerative disorders. Here we report that brain expression of key enzymes in the kynurenine pathway are significantly, but differentially, altered in neonatal and adult rats with BDV infection...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28399176/pathological-findings-in-the-red-fox-vulpes-vulpes-stone-marten-martes-foina-and-raccoon-dog-nyctereutes-procyonoides-with-special-emphasis-on-infectious-and-zoonotic-agents-in-northern-germany
#9
Charlotte Lempp, Nicole Jungwirth, Miguel L Grilo, Anja Reckendorf, Arlena Ulrich, Abbo van Neer, Rogier Bodewes, Vanessa M Pfankuche, Christian Bauer, Albert D M E Osterhaus, Wolfgang Baumgärtner, Ursula Siebert
Anthropogenic landscape changes contributed to the reduction of availability of habitats to wild animals. Hence, the presence of wild terrestrial carnivores in urban and peri-urban sites has increased considerably over the years implying an increased risk of interspecies spillover of infectious diseases and the transmission of zoonoses. The present study provides a detailed characterisation of the health status of the red fox (Vulpes vulpes), stone marten (Martes foina) and raccoon dog (Nyctereutes procyonoides) in their natural rural and peri-urban habitats in Schleswig-Holstein, Germany between November 2013 and January 2016 with focus on zoonoses and infectious diseases that are potentially threatening to other wildlife or domestic animal species...
2017: PloS One
https://www.readbyqxmd.com/read/28396321/albumin-in-the-presence-of-calcium-elicits-a-massive-increase-in-extracellular-bordetella-adenylate-cyclase-toxin
#10
Laura A Gonyar, Mary C Gray, Gregory J Christianson, Borna Mehrad, Erik L Hewlett
Pertussis (whooping cough), caused by Bordetella pertussis (Bp), is resurging in the United States and worldwide. Adenylate cyclase toxin (ACT) is a critical factor in establishing infection with Bp and acts by specifically inhibiting the response of myeloid leukocytes to the pathogen. We report here that serum components, as discovered during growth in fetal bovine serum (FBS), elicit a robust increase in the amount of ACT, and ≥90% of this ACT is localized to the supernatant, unlike growth without FBS in which ≥90% is associated with the bacterium...
April 10, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28387551/evaluation-of-nintendo-wii-balance-board-as-a-tool-for-measuring-postural-stability-after-sport-related-concussion
#11
Kian Merchant-Borna, Courtney Marie Cora Jones, Mattia Janigro, Erin B Wasserman, Ross A Clark, Jeffrey J Bazarian
CONTEXT: Recent changes to postconcussion guidelines indicate that postural-stability assessment may augment traditional neurocognitive testing when making return-to-participation decisions. The Balance Error Scoring System (BESS) has been proposed as 1 measure of balance assessment. A new, freely available software program to accompany the Nintendo Wii Balance Board (WBB) system has recently been developed but has not been tested in concussed patients. OBJECTIVE: To evaluate the feasibility of using the WBB to assess postural stability across 3 time points (baseline and postconcussion days 3 and 7) and to assess concurrent and convergent validity of the WBB with other traditional measures (BESS and Immediate Post-Concussion Assessment and Cognitive Test [ImPACT] battery) of assessing concussion recovery...
March 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28352667/hepcidin-mediated-iron-sequestration-protects-against-bacterial-dissemination-during-pneumonia
#12
Kathryn R Michels, Zhimin Zhang, Alexandra M Bettina, R Elaine Cagnina, Debora Stefanova, Marie D Burdick, Sophie Vaulont, Elizabeta Nemeth, Tomas Ganz, Borna Mehrad
Gram-negative pneumonia is a dangerous illness, and bacterial dissemination to the bloodstream during the infection is strongly associated with death. Antibiotic resistance among the causative pathogens has resulted in diminishing treatment options against this infection. Hepcidin is the master regulator of extracellular iron availability in vertebrates, but its role in the context of host defense is undefined. We hypothesized that hepcidin-mediated depletion of extracellular iron during Gram-negative pneumonia protects the host by limiting dissemination of bacteria to the bloodstream...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28346073/detection-of-clinically-significant-prostate-cancer-short-dual-pulse-sequence-versus-standard-multiparametric-mr-imaging-a-multireader-study
#13
Borna K Barth, Pieter J L De Visschere, Alexander Cornelius, Carlos Nicolau, Hebert Alberto Vargas, Daniel Eberli, Olivio F Donati
Purpose To compare the diagnostic performance of a short dual-pulse sequence magnetic resonance (MR) imaging protocol versus a standard six-pulse sequence multiparametric MR imaging protocol for detection of clinically significant prostate cancer. Materials and Methods This HIPAA-compliant study was approved by the regional ethics committee. Between July 2013 and March 2015, 63 patients from a prospectively accrued study population who underwent MR imaging of the prostate including transverse T1-weighted; transverse, coronal, and sagittal T2-weighted; diffusion-weighted; and dynamic contrast material-enhanced MR imaging with a 3-T imager at a single institution were included in this retrospective study...
March 27, 2017: Radiology
https://www.readbyqxmd.com/read/28344601/high-dose-rate-intraluminal-brachytherapy-prior-to-external-radiochemotherapy-in-locally-advanced-esophageal-cancer-preliminary-results
#14
Afsaneh Maddah Safaei, Reza Ghalehtaki, Nezhat Khanjani, Borna Farazmand, Mohammad Babaei, Ebrahim Esmati
PURPOSE: Dysphagia is a common initial presentation in locally advanced esophageal cancer and negatively impacts patient quality of life and treatment compliance. To induce fast relief of dysphagia in patients with potentially operable esophageal cancer high-dose-rate (HDR) brachytherapy was applied prior to definitive radiochemotherapy. MATERIAL AND METHODS: In this single arm phase II clinical trial between 2013 to 2014 twenty patients with locally advanced esophageal cancer (17 squamous cell and 3 adenocarcinoma) were treated with upfront 10 Gy HDR brachytherapy, followed by 50...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28288010/functional-connectivity-is-reduced-in-early-stage-primary-progressive-aphasia-when-atrophy-is-not-prominent
#15
Borna Bonakdarpour, Emily J Rogalski, Allan Wang, Jaiashre Sridhar, M M Mesulam, Robert S Hurley
Primary progressive aphasia (PPA) is a clinical syndrome of language decline caused by neurodegenerative pathology. Although language impairments in PPA are typically localized via the morphometric assessment of atrophy, functional changes may accompany or even precede detectable structural alterations, in which case resting state functional connectivity (RSFC) could provide an alternative approach. The goal of this study was to determine whether language network RSFC is reduced in early-stage PPA when atrophy is not prominent...
April 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28278254/characterizing-the-community-use-of-an-ultralight-wheelchair-with-on-the-fly-adjustable-seating-functions-a-pilot-study
#16
Johanne Mattie, Jaimie Borisoff, William C Miller, Borna Noureddin
An ultralight manual wheelchair that allows users to independently adjust rear seat height and backrest angle during normal everyday usage was recently commercialized. Prior research has been performed on wheelchair tilt, recline, and seat elevation use in the community, however no such research has been done on this new class of manual ultralight wheelchair with "on the fly" adjustments. The objective of this pilot study was to investigate and characterize the use of the two adjustable seating functions available on the Elevation™ ultralight dynamic wheelchair during its use in the community...
2017: PloS One
https://www.readbyqxmd.com/read/28255201/impaired-surface-expression-of-hla-dr-tlr2-tlr4-and-tlr9-in-ex-vivo-in-vitro-stimulated-monocytes-from-severely-injured-trauma-patients
#17
David Heftrig, Ramona Sturm, Elsie Oppermann, Kerstin Kontradowitz, Katrin Jurida, Lukas Schimunek, Mathias Woschek, Ingo Marzi, Borna Relja
Objective. Trauma patients (TP) frequently develop an imbalanced immune response that often causes infectious postinjury complications. Monocytes show a diminished capability of both producing proinflammatory cytokines and antigen presentation after trauma. TLR2, TLR4, and TLR9 recognize pathogens and subsequently activate monocytes. While there are conflictive data about TLR2 and TLR4 expression after trauma, no studies about the expression of TLR2, TLR4, TLR9, and HLA-DR on monocytes from TP after their secondary ex vivo-in vitro "hit" have been reported...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28228875/traumatic-nonanastomotic-axilloprofundal-ptfe-bypass-rupture-a-case-report
#18
Borna K Barth, Fabian Hässler, Oliver Graubitz
A 76-year-old male patient was admitted to our emergency department with painful swelling of the right lateral chest after a fall. Imaging revealed a hematoma, secondary to rupture of a synthetic axilloprofundal bypass. In an emergency surgical procedure, the spelled hematoma was evacuated and the graft legs were successfully ligated. The patient was discharged after an uneventful hospital stay. Traumatic bypass rupture because of blunt trauma is an exceedingly rare event; however, it must be taken into consideration in a patient with bypass surgery in his/her history...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28131102/correction-renal-cell-carcinoma-alters-endothelial-receptor-expression-responsible-for-leukocyte-adhesion
#19
Eva Juengel, Geraldine Krueger, Jochen Rutz, Karen Nelson, Isabella Werner, Borna Relja, Barbara Seliger, Beate Fisslthaler, Ingrid Fleming, Igor Tsaur, Axel Haferkamp, Roman A Blaheta
No abstract text is available yet for this article.
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28123175/a-novel-mutation-in-taz-causes-mitochondrial-respiratory-chain-disorder-without-cardiomyopathy
#20
Nurun N Borna, Yoshihito Kishita, Kaori Ishikawa, Kazuto Nakada, Jun-Ichi Hayashi, Yoshimi Tokuzawa, Masakazu Kohda, Hiromi Nyuzuki, Yzumi Yamashita-Sugahara, Takashi Nasu, Atsuhito Takeda, Kei Murayama, Akira Ohtake, Yasushi Okazaki
Tafazzin, encoded by the TAZ gene, is a mitochondrial membrane-associated protein that remodels cardiolipin (CL), an important mitochondrial phospholipid. TAZ mutations are associated with Barth syndrome (BTHS). BTHS is an X-linked multisystemic disorder affecting usually male patients. Through sequence analysis of TAZ, we found one novel mutation c.39_60del p.(Pro14Alafs*19) by whole-exome sequencing and a reported missense mutation c.280C>T p.(Arg94Cys) by Sanger sequencing in two male patients (Pt1 and Pt2)...
April 2017: Journal of Human Genetics
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